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https://www.readbyqxmd.com/read/28100422/osteoarthritis-year-in-review-2016-genetics-genomics-and-epigenetics
#1
REVIEW
J B J van Meurs
The purpose of this narrative review is to provide an overview of last year's publications in the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes arising from a Pubmed search on (epi)genetics in OA were identified. In addition, general developments in the fast evolving field of (epi)genetics are reviewed and relevance for the OA field is summarized. In the last 5 years, a number of genome-wide association studies have identified a modest number of genetic loci associated to OA...
December 22, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28098995/a-chemometrics-approach-to-the-investigation-of-the-intraspecific-variability-of-the-volatile-oil-of-eupatorium-tremulum-from-southern-brazil
#2
Tiago J T de Souza, Sérgio A L Bordignon, Miriam A Apel
Eupatorium tremulum is a South American shrub reported to cause cattle digestive intoxication, of which the volatile oil, mainly composed by bisabolane- and amorphane-type sesquiterpenoids, exhibits high quantitative variability. This report describes the application of chemometric tools for the identification of volatile compounds that characterize phenophasical changes in the plant. Preblooming, blooming, and postblooming specimens were paired-sampled and submitted to hydrodistillation and GC-MS analysis...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28094801/electronegative-ldl-mediated-cardiac-electrical-remodeling-in-a-rat-model-of-chronic-kidney-disease
#3
An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Ching-Hu Chung, Hsien-Yu Peng, Chia-Ming Chang, Ming-Jai Su, Chu-Huang Chen, Kuan-Cheng Chang
The mechanisms underlying chronic kidney disease (CKD)-associated higher risks for life-threatening ventricular tachyarrhythmias remain poorly understood. In rats subjected to unilateral nephrectomy (UNx), we examined cardiac electrophysiological remodeling and relevant mechanisms predisposing to ventricular arrhythmias. Adult male Sprague-Dawley rats underwent UNx (n = 6) or sham (n = 6) operations. Eight weeks later, the UNx group had higher serum blood urea nitrogen and creatinine levels and a longer electrocardiographic QTc interval than did the sham group...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28092934/visceral-leishmaniasis-treatment-outcome-and-its-determinants-in-northwest-ethiopia
#4
Berihun Assefa Dachew, Getachew Mebrahtu Welay, Kefyalew Addis Alene
Background: Poor treatment outcomes of visceral leishmaniasis (VL) are responsible for a high mortality rate in resource limited setting like Ethiopia. This study aimed at evaluating the magnitude and identifying determinants of poor VL treatment outcome in Kahsay Abera Hospital, Northwest Ethiopia. Methods: A hospital based retrospective follow up study was conducted among 595 VL patients who were admitted to Kahsay Abera Hospital, Northwest Ethiopia from October 2010 to April 2013...
December 28, 2016: Epidemiology and Health
https://www.readbyqxmd.com/read/28092785/integrated-ssfp-for-functional-brain-mapping-at-7t-with-reduced-susceptibility-artifact
#5
Kaibao Sun, Rong Xue, Peng Zhang, Zhentao Zuo, Zhongwei Chen, Bo Wang, Thomas Martin, Yi Wang, Lin Chen, Sheng He, Danny J J Wang
Balanced steady-state free precession (bSSFP) offers an alternative and potentially important tool to the standard gradient-echo echo-planar imaging (GE-EPI) for functional MRI (fMRI). Both passband and transition band based bSSFP have been proposed for fMRI. The applications of these methods, however, are limited by banding artifacts due to the sensitivity of bSSFP signal to off-resonance effects. In this article, a unique case of the SSFP-FID sequence, termed integrated-SSFP or iSSFP, was proposed to overcome the obstacle by compressing the SSFP profile into the width of a single voxel...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28092527/block-matching-distortion-correction-of-echo-planar-images-with-opposite-phase-encoding-directions
#6
Renaud Hedouin, Olivier Commowick, Elise Bannier, Benoit Scherrer, Maxime Taquet, Simon Warfield, Christian Barillot
By shortening the acquisition time of MRI, Echo Planar Imaging (EPI) enables the acqui- sition of a large number of images in a short time, com- patible with clinical constraints as required for diffusion or functional MRI. However such images are subject to large, local distortions disrupting their correspondence with the underlying anatomy. The correction of those distortions is an open problem, especially in regions where large deformations occur. We propose a new block-matching registration method to perform EPI distortion correction based on the acquisition of two EPI with opposite phase encoding directions (PED)...
January 9, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28092525/light-field-reconstruction-using-shearlet-transform
#7
Suren Vagharshakyan, Robert Bregovic, Atanas Gotchev
In this article we develop an image based rendering technique based on light field reconstruction from a limited set of perspective views acquired by cameras. Our approach utilizes sparse representation of epipolar-plane images (EPI) in shearlet transform domain. The shearlet transform has been specifically modified to handle the straight lines characteristic for EPI. The devised iterative regularization algorithm based on adaptive thresholding provides high-quality reconstruction results for relatively big disparities between neighboring views...
January 16, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28090273/the-effects-of-berberine-and-palmatine-on-efflux-pumps-inhibition-with-different-gene-patterns-in-pseudomonas-aeruginosa-isolated-from-burn-infections
#8
Seyed Sajjad Aghayan, Hamidreza Kalalian Mogadam, Mozhgan Fazli, Davood Darban-Sarokhalil, Seyed Sajjad Khoramrooz, Fereshteh Jabalameli, Somayeh Yaslianifard, Mehdi Mirzaii
BACKGROUND: Related Multidrug Resistance (MDR) to efflux pumps is a significant problem in treating infections caused by Pseudomonas aeruginosa (P. aeruginosa). Plant compounds have been identified as Pump Inhibitors (EPIs). In the current study, the potential effect of Berberine and Palmatine as EPIs were investigated on efflux pump inhibition through focusing on different gene patterns in P. aeruginosa isolated from burn infections. METHODS: All isolates were collected and identified using the standard biochemical tests...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28089986/estimating-glomerular-filtration-rate-for-the-full-age-spectrum-from-serum-creatinine-and-cystatin-c
#9
Hans Pottel, Pierre Delanaye, Elke Schaeffner, Laurence Dubourg, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J Lamb, Andrew D Rule, Stephen T Turner, Richard J Glassock, Vandréa De Souza, Luciano Selistre, Karolien Goffin, Steven Pauwels, Christophe Mariat, Martin Flamant, Natalie Ebert
BACKGROUND: We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAScrea) for estimating the glomerular filtration rate (GFR) for healthy and kidney-diseased subjects of all ages. The equation was based on the concept of normalized Scr and shows equivalent to superior prediction performance to the currently recommended equations for children, adolescents, adults and older adults. METHODS: Based on an evaluation of the serum cystatin C (ScysC) distribution, we defined normalization constants for ScysC (QcysC = 0...
January 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28089927/metabolism-of-selective-20-epi-vitamin-d3-analogs-in-rat-osteosarcoma-umr-106-cells-isolation-and-identification-of-four-novel-c-1-fatty-acid-esters-of-1%C3%AE-25-dihydroxy-16-ene-20-epi-vitamin-d3
#10
Caroline Ceailles Flarakos, Andrew Weiskopf, Matthew Robinson, Guoshun Wang, Paul Vouros, Gino J Sasso, Milan R Uskokovic, G Satyanarayana Reddy
Analogs of 1α,25-dihydroxyvitamin D3 (S1) with 20-epi modification (20-epi analogs) possess unique biological properties. We previously reported that 1α,25-dihydroxy-20-epi-vitamin D3 (S2), the basic 20-epi analog is metabolized into less polar metabolites (LPMs) in rat osteosarcoma cells (UMR-106) but not in a perfused rat kidney. Furthermore, we also noted that only selective 20-epi analogs are metabolized into LPMs. For example, 1α,25-dihydroxy-16-ene-20-epi-vitamin D3 (S4), but not 1α,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3 (S5) is metabolized into LPMs...
January 12, 2017: Steroids
https://www.readbyqxmd.com/read/28089724/potential-applications-of-lipid-peroxidation-products-f4-neuroprostanes-f3-neuroprostanesn-6-dpa-f2-dihomo-isoprostanes-and-f2-isoprostanes-in-the-evaluation-of-the-allograft-function-in-renal-transplantation
#11
Ignacio De Las Heras-Gómez, Sonia Medina, Teresa Casas-Pina, Lidia Marín-Soler, Anna Tomás, Pedro Martínez-Hernández, Camille Oger, Jean-Marie Galano, Thierry Durand, Luisa Jimeno, Santiago Llorente, Elena Lozoya, Federico Ferreres, Ángel Gil-Izquierdo
F4-neuroprostanes, F3-neuroprostanesn-6 DPA, and F2-dihomo-isoprostanes, metabolites of non-enzymatic lipid peroxidation of polyunsaturated fatty acids [docosahexaenoic acid, n-6 docosapentanoic acid, and adrenic acid respectively], have become important biomarkers for oxidative stress in several diseases like epilepsy and alzheimer. These biomarkers and the 15-F2t-isoprostane (also known as 8-iso-PGF2α), a F2-isoprostane isomer measured as reference oxidative marker at systemic level, were analyzed by UHPLC-QqQ-MS/MS in the urine of 60 renal recipients from cadaveric donors of the Nephrology Unit of the University Hospital Virgen de la Arrixaca, at six different times during the first six months after renal transplantation, and were compared with a control group of 60 healthy subjects from the same hospital...
January 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28088175/prevalence-and-risk-factors-for-cardiovascular-disease-among-chronic-kidney-disease-patients-results-from-the-chinese-cohort-study-of-chronic-kidney-disease-c-stride
#12
Jun Yuan, Xin-Rong Zou, Si-Ping Han, Hong Cheng, Lan Wang, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao, Xiao-Qin Wang
BACKGROUND: Although a high incidence of cardiovascular disease (CVD) is observed among chronic kidney disease (CKD) patients in developed countries, limited information is available about CVD prevalence and risk factors in the Chinese CKD population. The Chinese Cohort of Chronic Kidney Disease (C-STRIDE) was established to investigate the prevalence and risk factors of CVD among Chinese CKD patients. METHODS: Participants with stage 1-4 CKD (18-74 years of age) were recruited at 39 clinical centers located in 28 cities from 22 provinces of China...
January 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28087256/manganese-superoxide-dismutase-and-glutathione-peroxidase-1-contribute-to-the-rise-and-fall-of-mitochondrial-reactive-oxygen-species-which-drive-oncogenesis
#13
REVIEW
Dede N Ekoue, Chenxia He, Alan M Diamond, Marcelo G Bonini
Reactive oxygen species (ROS) largely originating in the mitochondria play essential roles in the metabolic and (epi)genetic reprogramming of cancer cell evolution towards more aggressive phenotypes. Recent studies have indicated that the activity of superoxide dismutase (SOD2) may promote tumor progression by serving as a source of hydrogen peroxide (H2O2). H2O2 is a form of ROS that is particularly active as a redox agent affecting cell signaling due to its ability to freely diffuse out of the mitochondria and alter redox active amino acid residues on regulatory proteins...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28086816/rationale-description-and-baseline-findings-of-a-community-based-prospective-cohort-study-of-kidney-function-amongst-the-young-rural-population-of-northwest-nicaragua
#14
Marvin González-Quiroz, Armando Camacho, Dorien Faber, Aurora Aragón, Catharina Wesseling, Jason Glaser, Jennifer Le Blond, Liam Smeeth, Dorothea Nitsch, Neil Pearce, Ben Caplin
BACKGROUND: An epidemic of Mesoamerican Nephropathy (MeN) is killing thousands of agricultural workers along the Pacific coast of Central America, but the natural history and aetiology of the disease remain poorly understood. We have recently commenced a community-based longitudinal study to investigate Chronic Kidney Disease (CKD) in Nicaragua. Although logistically challenging, study designs of this type have the potential to provide important insights that other study designs cannot...
January 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28081498/enhancing-analysis-throughput-sensitivity-and-specificity-in-lc-esi-ms-ms-assay-of-plasma-25-hydroxyvitamin-d3-by-derivatization-with-triplex-4-4-dimethylaminophenyl-1-2-4-triazoline-3-5-dione-daptad-isotopologues
#15
Shoujiro Ogawa, Hiroki Kittaka, Akiho Nakata, Kenji Komatsu, Takahiro Sugiura, Mamoru Satoh, Fumio Nomura, Tatsuya Higashi
The plasma/serum concentration of 25-hydroxyvitamin D3 [25(OH)D3] is a diagnostic index for vitamin D deficiency/insufficiency, which is associated with a wide range of diseases, such as rickets, cancer and diabetes. We have reported that the derivatization with 4-(4-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) works well in the liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) assay of the serum/plasma 25(OH)D3 for enhancing the sensitivity and the separation from a potent interfering metabolite, 3-epi-25-hydroxyvitamin D3 [3-epi-25(OH)D3]...
November 17, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28077908/magnetic-resonance-imaging-of-a-case-of-central-neurocytoma
#16
Kreshnike Dedushi, Serbeze Kabashi, Mehmet Sahin Ugurel, Naser Ramadani, Sefedin Mucaj, Kamber Zeqiraj
BACKGROUND: The purpose of this study is to investigate the MRI features of central neurocytoma. CASE REPORT: A 45 year old man with 3 months of worsening daily headaches. These headaches were diffuse, lasted for several hours, and mostly occurred in the morning. She was initially diagnosed and treated for migraines but later he had epileptic attack and diplopia and neurolog recomaded MRI. METHODS: precontrast MRI; TSE/T2Wsequence in axial/coronal planes; 3D-Hi-resolution T1W sagittal; FLAIR/T2W axial; FLAIR/T2W and Flash/T2W oblique coronal plane (perpendicular to temporal lobes) GRE/T2W axial plane for detection of heme products...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28077620/mitogen-induced-distinct-epi-alleles-are-phosphorylated-at-either-h3s10-or-h3s28-depending-on-h3k27-acetylation
#17
Dilshad H Khan, Shannon Healy, Shihua He, Daniel Lichtensztejn, Ludger Klewes, Kiran L Sharma, Veronica Lau, Sabine Mai, Geneviève P Delcuve, James R Davie
Stimulation of the MAPK pathway results in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphorylation of histone H3 at serine 10 or 28 and expression of immediate-early (IE) genes. In 10T1/2 mouse fibroblasts, phosphorylation of H3S10 and H3S28 occurs on different H3 molecules and in different nuclear regions. Likewise, we show that mitogen-induced H3S10 and H3S28 phosphorylation occurs in separate pools in human primary fibroblasts. High-resolution imaging studies on both cell types have revealed that H3S10 and H3S28 phosphorylation events can be induced in a single cell but on different alleles, giving rise to H3S10ph and H3S28ph epi-alleles...
January 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28077303/analysis-and-correction-of-field-fluctuations-in-fmri-data-using-field-monitoring
#18
Saskia Bollmann, Lars Kasper, S Johanna Vannesjo, Andreea O Diaconescu, Benjamin E Dietrich, Simon Gross, Klaas E Stephan, Klaas P Pruessmann
This work investigates the role of magnetic field fluctuations as a confound in fMRI. In standard fMRI experiments with single-shot EPI acquisition the uniform and gradient components of the magnetic field were recorded with NMR field sensors. By principal component analysis it is found that differences of field evolution between the EPI readouts are explainable by few components relating to slow and within-shot field dynamics of hardware and physiological origin. The impact of fluctuating field components is studied by selective data correction and assessment of its influence on image fluctuation and SFNR...
January 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28075465/monoclonal-antibody-zt-g4-targeting-ron-receptor-tyrosine-kinase-enhances-chemosensitivity-of-bladder-cancer-cells-to-epirubicin-by-promoting-g1-s-arrest-and-apoptosis
#19
Jun-Feng Chen, Bi-Xia Yu, Rui Yu, Liang Ma, Xiu-Yi Lv, Yue Cheng, Qi Ma
Epirubicin (EPI) is one of the most used intravesical chemotherapy agents after transurethral resection to non-muscle invasive bladder tumors (NMIBC) to prevent cancer recurrence and progression. However, even after resection of bladder tumors and intravesical chemotherapy, half of them will recur and progress. RON is a membrane tyrosine kinase receptor usually overexpressed in bladder cancer cells and associated with poor pathological features. This study aims to investigate the effects of anti-RON monoclonal antibody Zt/g4 on the chemosensitivity of bladder cells to EPI...
February 2017: Oncology Reports
https://www.readbyqxmd.com/read/28070869/fast-t1-and-t2-mapping-methods-the-zoomed-u-flare-sequence-compared-with-epi-and-snapshot-flash-for-abdominal-imaging-at-11-7-tesla
#20
Géraldine Pastor, María Jiménez-González, Sandra Plaza-García, Marta Beraza, Torsten Reese
OBJECTIVE: A newly adapted zoomed ultrafast low-angle RARE (U-FLARE) sequence is described for abdominal imaging applications at 11.7 Tesla and compared with the standard echo-plannar imaging (EPI) and snapshot fast low angle shot (FLASH) methods. MATERIALS AND METHODS: Ultrafast EPI and snapshot-FLASH protocols were evaluated to determine relaxation times in phantoms and in the mouse kidney in vivo. Owing to their apparent shortcomings, imaging artefacts, signal-to-noise ratio (SNR), and variability in the determination of relaxation times, these methods are compared with the newly implemented zoomed U-FLARE sequence...
January 9, 2017: Magma
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