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Yasuhiro Horibata, Orly Elpeleg, Ayelet Eran, Yoshio Hirabayashi, David Savitzki, Galit Tal, Hanna Mandel, Hiroyuki Sugimoto
Ethanolamine phosphotransferase 1 (EPT1), also known as selenoprotein 1 (SELENOI), is an enzyme that transfers phosphoethanolamine from cytidine diphosphate (CDP)-ethanolamine to lipid acceptors to produce ethanolamine glycerophospholipids such as diacyl-linked phosphatidylethanolamine (PE) and ether-linked plasmalogen (plasmenyl-PE). However, to date there has been no analysis of the metabolomic consequence of the mutation of EPT1 on the concentration of ethanolamine glycerophospholipids in mammalian cells...
March 2, 2018: Journal of Lipid Research
Vaishnavi Calisa, Jonathan C Craig, Kirsten Howard, Martin Howell, Stephen Alexander, Steven J Chadban, Philip Clayton, Wai H Lim, John Kanellis, Kate Wyburn, David W Johnson, Stephen P McDonald, Helen Opdam, Jeremy R Chapman, Jean Yang, Germaine Wong
BACKGROUND: To determine the incremental gains in graft and patient survival under a risk-based, deceased donor kidney allocation compared to the current Australian algorithm. METHODS: Risk-based matching algorithms were applied to first graft, kidney only recipients (n=7513) transplanted in Australia between 1994 and 2013. Probabilistic models were used to compare the waiting time, life and quality-adjusted life years and graft years between the 8 risk-based allocation strategies against current practice...
February 26, 2018: Transplantation
Sherri Lynne Katz, Thuy Mai Luu, Anne-Monique Nuyt, Thierry Lacaze, Kristi Brae Adamo, Ian Adatia, Tilman Humpl, Robert Peter Jankov, Theo J Moraes, Katharina Staub, Michael K Stickland, Bernard Thebaud
Bronchopulmonary dysplasia, the most common pulmonary complication of extremely preterm (EPT) birth, has longstanding multiorgan repercussions, with increasing reports of emphysema and cardiac disease in early adulthood. There are currently no clear recommendations pertaining to best practices for optimal multidisciplinary cardiorespiratory follow-up of EPT children. We report the outcomes of a 2-day consensus workshop involving a Canadian panel of 31 multidisciplinary experts with the goal of improvement and standardization of the cardiopulmonary follow-up care of EPT infants (i...
May 2017: Paediatrics & Child Health
Gregor Fuhrmann, Rona Chandrawati, Paresh A Parmar, Timothy J Keane, Stephanie A Maynard, Sergio Bertazzo, Molly M Stevens
Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers, and disease biomarkers. These natural cell-derived nanoparticles are postulated to be biocompatible, stable under physiological conditions, and to show reduced immunogenicity as compared to other synthetic nanoparticles. Although initial clinical trials are ongoing, the use of EVs for therapeutic applications may be limited due to undesired off-target activity and potential "dilution effects" upon systemic administration which may affect their ability to reach their target tissues...
February 23, 2018: Advanced Materials
Lauren N Borchardt, Michelle L Pickett, Kevin T Tan, Alexis M Visotcky, Amy L Drendel
BACKGROUND: Expedited partner therapy (EPT) is an effective strategy for partner management of sexually transmitted infections. Some states, including Wisconsin, allow EPT prescriptions to be filled without a patient name. This study determined the refusal rates of nameless EPT prescriptions in Milwaukee pharmacies. METHODS: In this cross-sectional study, three trained research assistants of different age, gender and race posed as 'patients' and visited 50 pharmacy locations from one pharmacy chain in Milwaukee County, WI to fill nameless EPT prescriptions...
October 25, 2017: Sexually Transmitted Diseases
Vera Westin, Susanna Klevebro, Magnus Domellöf, Mireille Vanpée, Boubou Hallberg, Elisabeth Stoltz Sjöström
BACKGROUND AND AIMS: Extremely preterm (EPT) infants are at high risk for malnutrition due to immaturity and medical complications and they often accumulate nutritional deficits and experience growth faltering during treatment at neonatal intensive care units (NICUs). Enhanced intake of energy and protein during the first weeks of life improves weight gain and head circumference growth. The optimal nutritional strategy for these infants' health and long-term development remains unknown...
February 2018: Clinical Nutrition ESPEN
Shengli Li, Weifang Yang, Lizhu Wang, Kai Chen, Sheng Xu, Beixin Wang
Key environmental factors and the mechanisms of their influence on the physicochemical habitats and macroinvertebrate communities of streams may vary among ecoregions. We studied the differences in environmental (land use and physicochemical) factors and the mechanisms of their influence on macroinvertebrate assemblages between mountain and lowland ecoregions in central China. We applied generalized linear models to identify key environmental factors that influence macroinvertebrate metrics consisting of taxa richness, Ephemeroptera, Plecoptera, and Trichoptera (EPT) taxa, percentages of EPT and intolerant individuals, and the Shannon-Wiener diversity index...
February 20, 2018: Environmental Monitoring and Assessment
Jenny Bolk, Nelly Padilla, Lea Forsman, Lina Broström, Kerstin Hellgren, Ulrika Åden
OBJECTIVES: This exploratory study aimed to investigate associations between neonatal brain volumes and visual-motor integration (VMI) and fine motor skills in children born extremely preterm (EPT) when they reached 6½ years of age. SETTING: Prospective population-based cohort study in Stockholm, Sweden, during 3 years. PARTICIPANTS: All children born before gestational age, 27 weeks, during 2004-2007 in Stockholm, without major morbidities and impairments, and who underwent MRI at term-equivalent age...
February 17, 2018: BMJ Open
Nishtha Gupta, Mandeep S Grewal, Munish Gairola, Stutee Grewal, Parveen Ahlawat
INTRODUCTION: Teeth may react negatively to pulp sensitivity testing in patients who have undergone radiotherapy. The aim of the current investigation was to evaluate the pulp sensibility of posterior teeth at 4, 6, and 12 months in patients who have undergone radiotherapy for oral and oropharyngeal malignancies. METHODS: Seventy-nine patients diagnosed with malignant oral and oropharyngeal cancer undergoing radiotherapy underwent cold thermal pulp sensitivity testing and electric pulp testing of 4 teeth, 1 from each quadrant...
February 13, 2018: Journal of Endodontics
L Sibulesky, C E Kling, C Blosser, C K Johnson, A P Limaye, R Bakthavatsalam, N Leca, J D Perkins
KDRI introduced in 2009 included Hepatitis C serologic but not viremic status of the donors. With NAT testing now being mandatory, further evaluation of these donors is possible. We conducted a retrospective matched case-control analysis of adult deceased donor kidney transplants performed between 12/5/2014 to 12/31/2016 with the KDRI score and HCV Ab and NAT testing status obtained from UNOS database. The 205 aviremic Hep C Ab+ NAT - kidney transplants were compared to KDRI matched control kidneys that were Hep C Ab-NAT-...
February 16, 2018: American Journal of Transplantation
Ahmed Zihni, William D Gerull, Jaime A Cavallo, Tianjia Ge, Shuddhadeb Ray, Jason Chiu, L Michael Brunt, Michael M Awad
BACKGROUND: Robotic platforms have the potential advantage of providing additional dexterity and precision to surgeons while performing complex laparoscopic tasks, especially for those in training. Few quantitative evaluations of surgical task performance comparing laparoscopic and robotic platforms among surgeons of varying experience levels have been done. We compared measures of quality and efficiency of Fundamentals of Laparoscopic Surgery task performance on these platforms in novices and experienced laparoscopic and robotic surgeons...
March 2018: Journal of Surgical Research
Konstantinos Stefanidis, Yiannis Panagopoulos, Maria Mimikou
Streams and rivers are among the most threatened ecosystems in Europe due to the combined effects of multiple pressures related to anthropogenic activities. Particularly in the Mediterranean region, changes in hydromorphology along with increased nutrient loadings are known to affect the ecological functions and ecosystem services of streams and rivers with the anticipated climate change being likely to further impair their functionality and structure. In this study, we investigated the combined effects of agricultural driven stressors on the ecology and delivered services of the Pinios river basin in Greece under three future world scenarios developed within the EU funded MARS project...
February 1, 2018: Science of the Total Environment
Matthias H Mueller, Peter Huggenberger, Jannis Epting
Increasing anthropogenic impacts lead to elevated temperatures of the shallow subsurface, including the unsaturated and groundwater saturated zone, in many urban areas in comparison to unaffected natural thermal states. The "current thermal state" of four groundwater bodies in the urban area of Basel-City, Switzerland, was investigated by means of high-resolution multilevel temperature wells and numerical 3D groundwater flow and heat transport models. The calibrated and validated numerical groundwater flow and heat transport models allow evaluating and comparing groundwater and heat fluxes for the investigated groundwater bodies and defined cross-sections for differing urban districts, e...
February 5, 2018: Science of the Total Environment
Qiang Wang, Martina Roß-Nickoll, Di Wu, Wei Deng, Zhijian Wang, Xingzhong Yuan, Yaoguang Zhang
Urban areas and their development depress water physicochemical properties, river habitats and aquatic biotic integrity worldwide. Benthic macroinvertebrates at 61 sites representing three types of river reach locations (upstream rural areas, intermediate and downstream of urban areas) on the Liangtan River, a rapidly urbanized river with untreated sewage discharge in southwest China, were examined to compare their community composition and diversity. Their relationships with environmental variables were also explored...
January 28, 2018: Science of the Total Environment
Jennifer Z Qin, Clarissa P Diniz, Jenell S Coleman
BACKGROUND: Addressing record high rates of Chlamydia trachomatis (Ct) incidence in the United States (U.S.) requires the utilization of effective strategies, such as expedited partner therapy (EPT), to reduce reinfection and further transmission. EPT, which can be given as a prescription or medication, is a strategy to treat the sexual partners of index patients diagnosed with a sexually transmitted infection (STI) without prior medical evaluation of the partners. OBJECTIVE: There are multiple steps in the prescription-EPT cascade and we sought to identify pharmacy-level barriers to implementing prescription-EPT for Ct treatment...
January 31, 2018: American Journal of Obstetrics and Gynecology
Robert Egessa, Gandhi Willy Pabire, Henry Ocaya
An investigation was conducted on the macro-benthic fauna of the Napoleon Gulf in the northern part of Lake Victoria from March 2011 to December 2016 at the cage fish farm. The aim was to examine the likely impact of cage aquaculture on macro-benthic invertebrates. Cage aquaculture is now a common practice on Lake Victoria yet little is known about its long-term effect on macro-benthic faunal assemblages. Temporal variation indicated a general decline in annual faunal density at the farm area with corresponding stability at upstream (control) and downstream sites...
February 2, 2018: Environmental Monitoring and Assessment
A Jain, J R Baker, J W Chen
BACKGROUND: Esophageal pressure topography (EPT) diagnosis of ineffective esophageal motility (IEM) can be non-specific with unclear clinical significance. AIMS: To determine whether peristaltic vigor or lower esophageal sphincter (LES) integrity is associated with poor clearance and acid reflux in IEM. METHODS: Bolus clearance on high-resolution impedance manometry (HRIM) and available reflux studies in patients with IEM were retrospectively reviewed...
January 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Yinying Sheng, Youlu Hua, Xiaojian Wang, Xueyang Zhao, Lianxi Chen, Hanyu Zhou, James Wang, Christopher C Berndt, Wei Li
The technology of high-density electropulsing has been applied to increase the performance of metallic materials since the 1990s and has shown significant advantages over traditional heat treatment in many aspects. However, the microstructure changes in electropulsing treatment (EPT) metals and alloys have not been fully explored, and the effects vary significantly on different material. When high-density electrical pulses are applied to metals and alloys, the input of electric energy and thermal energy generally leads to structural rearrangements, such as dynamic recrystallization, dislocation movements and grain refinement...
January 24, 2018: Materials
David M Bland, Clayton O Jarrett, Christopher F Bosio, B Joseph Hinnebusch
Fleas can transmit Yersinia pestis by two mechanisms, early-phase transmission (EPT) and biofilm-dependent transmission (BDT). Transmission efficiency varies among flea species and the results from different studies have not always been consistent. One complicating variable is the species of rodent blood used for the infectious blood meal. To gain insight into the mechanism of EPT and the effect that host blood has on it, fleas were fed bacteremic mouse, rat, guinea pig, or gerbil blood; and the location and characteristics of the infection in the digestive tract and transmissibility of Y...
January 22, 2018: PLoS Pathogens
Mehdi Shajari, Sherin Khalil, Wolfgang J Mayer, Ghada Al-Khateeb, Myriam Böhm, Kerstin Petermann, Eva Hemkeppler, Thomas Kohnen
PURPOSE: To evaluate the effect of fragmentation patterns (pie pattern versus grid pattern) on effective phacoemulsification time (EPT). SETTING: Department of Ophthalmology, Goethe University, Frankfurt am Main, Germany. DESIGN: Retrospective case series. METHODS: Eyes that had femtosecond laser-assisted cataract surgery were included. One half of the group was treated with the pie pattern. The preoperative lens density was evaluated by Scheimpflug imaging (Pentacam)...
December 2017: Journal of Cataract and Refractive Surgery
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