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https://www.readbyqxmd.com/read/28916493/cell-mediated-enzyme-prodrug-cancer-therapies
#1
Rachael Mooney, Asma Abdul Majid, Jennifer Batalla, Alexander J Annala, Karen S Aboody
Cell-directed gene therapy is a promising new frontier for the field of targeted cancer therapies. Here we discuss the current pre-clinical and clinical use of cell-mediated enzyme prodrug therapy (EPT) directed against solid tumors and avenues for further development. We also discuss some of the challenges encountered upon translating these therapies to clinical trials. Upon sufficient development, cell-mediated enzyme prodrug therapy has the potential to maximize the distribution of therapeutic enzymes within the tumor environment, localizing conversion of prodrug to active drug at the tumor sites thereby decreasing off-target toxicities...
September 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28912968/bimanual-microincision-cataract-surgery-versus-coaxial-microincision-cataract-surgery-a-meta-analysis-of-randomized-controlled-trials-and-cohort-studies
#2
Chenxi Fu, Naipin Chu, Xiaoning Yu, Ke Yao
PURPOSE: This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision cataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). METHODS: Three databases were searched for papers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative outcomes were included in the final meta-analysis: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), mean surgery time, best-corrected visual acuity (BCVA), central corneal thickness (CCT), and increased CCT...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28890971/quantitative-interpretation-of-impedance-spectroscopy-data-on-porous-lsm-electrodes-using-x-ray-computed-tomography-and-bayesian-model-based-analysis
#3
Giuseppe F Brunello, William K Epting, Juwana de Silva, Paul A Salvador, Shawn Litster, Harry O Finklea, Yueh-Lin Lee, Kirk R Gerdes, David S Mebane
It is broadly understood that strontium-doped lanthanum manganate (LSM) cathodes for solid oxide fuel cells (SOFCs) have two pathways for the reduction of oxygen: a surface-mediated pathway culminating in oxygen incorporation into the electrolyte at the triple-phase boundary (TPB), and a bulk-mediated pathway involving oxygen transfer across the electrode-electrolyte interface. Patterned electrode and thin film experiments have shown that both pathways are active in LSM. Porous electrode geometries more commonly found in SOFCs have not been amenable for precise measurement of active electrode width because of the difficulty in precisely measuring the electrode geometry...
September 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28890767/application-of-aquatic-insects-ephemeroptera-plecoptera-and-trichoptera-in-water-quality-assessment-of-malaysian-headwater
#4
Suhaila Ab Hamid, Che Salmah Md Rawi
The Ephemeroptera, Plecoptera and Trichoptera (EPT) community structure and the specific sensitivity of certain EPT genera were found to be influenced by water parameters in the rivers of Gunung Jerai Forest Reserve (GJFR) in the north of peninsular Malaysia. The scores of EPT taxa richness of >10 in all rivers indicated all rivers' habitats were non-impacted, having good water quality coinciding with Class I and Class II of Malaysian water quality index (WQI) classification of potable water. The abundance of EPT was very high in Teroi River (9,661 individuals) but diversity was lower (22 genera) than Tupah River which was highly diverse (28 genera) but lower in abundance (4,263 individuals)...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28890763/ephemeroptera-plecoptera-and-trichoptera-insecta-abundance-diversity-and-role-in-leaf-litter-breakdown-in-tropical-headwater-river
#5
Suhaila Ab Hamid, Che Salmah Md Rawi
Leaf litter decomposition in a tropical stream was examined in two types of leaf packs; single species leaf packs of Pometia pinnata and two species leaf packs of equal combination of Pometia pinnata and Dolichandrone spathacea leaves. Both leaf packs were immersed in a river and weekly examined for remains of decomposed leaves and presence of EPT. In the control leaf packs, leaves in the two species leaf packs treatments decomposed within 35 days, faster than in single species leaf packs which decomposed after 42 days...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28884038/differential-diagnosis-of-parkinson-disease-essential-tremor-and-enhanced-physiological-tremor-with-the-tremor-analysis-of-emg
#6
Jie Zhang, Yan Xing, Xiuli Ma, Liqun Feng
We investigate the differential diagnostic value of tremor analysis of EMG on Parkinson's disease (PD), essential tremor (ET), and enhanced physiological tremor (EPT). Clinical data from 25 patients with PD, 20 patients with ET, and 20 patients with EPT were collected. The tremor frequency and muscle contraction pattern of the resting, posture, and 500 g and 1000 g overload were recorded. The frequency of PD tremor was 4-6 Hz, and the frequency of ET was also in this range; the frequency of EPT is 6-12 hz having some overlap with PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28879637/oligo-p-phenylenevinylene-derivatives-as-electron-transfer-matrices-for-uv-maldi
#7
Laura J Castellanos-García, Brian Castro Agudelo, Hernando F Rosales, Melissa Cely, Christian Ochoa-Puentes, Cristian Blanco-Tirado, Cesar A Sierra, Marianny Y Combariza
Phenylenevinylene oligomers (PVs) have outstanding photophysical characteristics for applications in the growing field of organic electronics. Yet, PVs are also versatile molecules, the optical and physicochemical properties of which can be tuned by manipulation of their structure. We report the synthesis, photophysical, and MS characterization of eight PV derivatives with potential value as electron transfer (ET) matrices for UV-MALDI. UV-vis analysis show the presence of strong characteristic absorption bands in the UV region and molar absorptivities at 355 nm similar or higher than those of traditional proton (CHCA) and ET (DCTB) MALDI matrices...
September 6, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28870530/abnormal-responses-to-local-esophageal-food-allergen-injections-in-adult-patients-with-eosinophilic-esophagitis
#8
Marijn J Warners, Ingrid Terreehorst, René M van den Wijngaard, Jaap Akkerdaas, Betty C A M van Esch, Ronald van Ree, Serge A Versteeg, Andreas J P M Smout, Albert J Bredenoord
Skin tests and measurement of serum levels of immunoglobulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic esophagitis (EoE). We investigated whether an esophageal prick test (EPT), in which the esophageal mucosa is challenged by local injection of allergen extracts, could identify individuals with esophageal sensitization. During endoscopy 6 allergens were injected in the esophagus of 8 patients with EoE and 3 patients without EoE (controls). A second endoscopy was performed after 24 hrs to evaluate delayed responses...
September 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28860416/estrogen-progestin-therapy-causes-a-greater-increase-in-spinal-bone-mineral-density-than-estrogen-therapy-a-systematic-review-and-meta-analysis-of-controlled-trials-with-direct-randomization
#9
J C Prior, V R Seifert-Klauss, D Giustini, J D Adachi, S Kalyan, A Goshtasebi
OBJECTIVE: To assess whether progesterone (P4) or osteoblast P4 receptor-acting progestin (P) contributed to estrogen (E) therapy-related increased areal bone mineral density (BMD) in randomized controlled trials (RCT) with direct randomization to estrogen (ET) or estrogen-progestin (EPT) therapy. METHODS: Systematic literature searches in biomedical databases identified RCT with direct randomization and parallel estrogen doses that measured spinal BMD change/year...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28833871/electric-pulp-test-threshold-responses-in-healthy-incisors-canines-premolars-and-molars
#10
Marija Šimović, Ivan Pavušek, Ana Ivanišević Malčić, Silvana Jukić, Goranka Prpić Mehičić, Jurica Matijević
The purpose of this study was to determine the range of threshold responses of healthy dental pulps and test the reproducibility of the electric pulp test (EPT). Forty-nine dental students participated in the study. Sound teeth in both arches, except third molars, were included. The teeth were isolated using cotton rolls and dried with compressed air, and the threshold responses were recorded. Participants stopped the stimulus increase by pressing the switch at the first sensation of discomfort. The measurements were repeated after 30 days...
August 18, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/28832996/motion-perception-and-form-discrimination-in-extremely-preterm-school-aged-children
#11
Mariagrazia Benassi, Roberto Bolzani, Lea Forsman, Ulrika Ådén, Lena Jacobson, Sara Giovagnoli, Kerstin Hellgren
This population-based study evaluated motion and form perception in 71 children born extreme premature (EPT; < 27 gestational weeks), aged 6.5 years, as compared to a matched group of 79 control children born at term. Motion and form perception were evaluated by motion coherence and form coherence tests. The EPT group showed a poorer performance on both tasks as compared to the control group. However, after controlling for IQ and visual acuity, the EPT group showed only a significant deficit in motion perception...
August 22, 2017: Child Development
https://www.readbyqxmd.com/read/28831063/sterol-targeting-drugs-reveal-life-cycle-stage-specific-differences-in-trypanosome-lipid-rafts
#12
Aabha I Sharma, Cheryl L Olson, João I Mamede, Felipe Gazos-Lopes, Conrad L Epting, Igor C Almeida, David M Engman
Cilia play important roles in cell signaling, facilitated by the unique lipid environment of a ciliary membrane containing high concentrations of sterol-rich lipid rafts. The African trypanosome Trypanosoma brucei is a single-celled eukaryote with a single cilium/flagellum. We tested whether flagellar sterol enrichment results from selective flagellar partitioning of specific sterol species or from general enrichment of all sterols. While all sterols are enriched in the flagellum, cholesterol is especially enriched...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28830056/multiple-stressor-effects-on-stream-macroinvertebrate-communities-a-mesocosm-experiment-manipulating-salinity-fine-sediment-and-flow-velocity
#13
Arne J Beermann, Vasco Elbrecht, Svenja Karnatz, Li Ma, Christoph D Matthaei, Jeremy J Piggott, Florian Leese
Stream ecosystems are impacted by multiple stressors worldwide. Recent studies have shown that the effects of multiple stressors are often complex and difficult to predict based on the effects of single stressors. More research is needed to understand stressor impacts on stream communities and to design appropriate counteractions. We carried out an outdoor mesocosm experiment to assess single and interactive multiple-stressor effects on stream macroinvertebrates in a setup with controlled application of three globally important stressors, namely, reduced stream flow velocity, deposition of fine sediment and increased chloride concentration in a full-factorial design...
August 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28829299/electrical-properties-tomography-based-on-b1-maps-in-mri-principles-applications-and-challenges
#14
Jiaen Liu, Yicun Wang, Ulrich Katscher, Bin He
OBJECTIVE: The purpose is to provide a comprehensive review of the electrical properties tomography (EPT) technique, which was introduced to image the electrical properties (EPs) of tissue noninvasively by exploiting the measured B1 field data of MRI. METHODS: We reviewed the principle of EPT, reconstruction methods, biomedical applications such as tumor imaging, and existing challenges. As a key application of EPT, the estimation of specific absorption rate (SAR) due to MRI was discussed in the background of elevated risk of tissue heating at high field...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28805728/nano-charged-polypropylene-application-realistic-perspectives-for-enhancing-durability
#15
Carlo Naddeo, Luigi Vertuccio, Giuseppina Barra, Liberata Guadagno
Isotactic polypropylene/multi-walled carbon nanotube (iPP/MWCNTs) films have been exposed to accelerated weathering in a UV device for increasing times. The effect of UV irradiation on the structural and chemical changes has been investigated. The resistance to accelerated photooxidation of (iPP/MWCNTs) films has been compared to the photooxidation behaviour of unfilled polypropylene films with the same structural organization. The chemical and structural modifications resulting from photooxidation have been followed using infrared spectroscopy, calorimetric and diffractometric analysis...
August 14, 2017: Materials
https://www.readbyqxmd.com/read/28796699/serum-uric-acid-levels-and-hormone-therapy-type-a-retrospective-cohort-study-of-postmenopausal-women
#16
Jae H Jung, Gwan G Song, Young H Lee, Jae-Hoon Kim, Myung H Hyun, Sung J Choi
OBJECTIVE: Serum uric acid levels increase in postmenopausal women, but decrease when hormone therapy (HT) is administered. No study has, however, evaluated the effects of different types of HT on serum uric acid levels. We therefore examined whether estrogen therapy (ET), estrogen plus progestogen therapy (EPT), and tibolone use affected serum uric acid levels in this population. METHODS: We performed a retrospective cohort study of postmenopausal women. From 2005 to 2015, postmenopausal women who had undergone blood uric acid-level testing at least twice were enrolled...
August 7, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28792768/role-of-hydrogen-bonding-in-photoinduced-electron-proton-transfer-from-phenols-to-a-polypyridine-ru-complex-with-a-proton-accepting-ligand
#17
Sergei V Lymar, Mehmed Z Ertem, Anna Lewandowska-Andralojc, Dmitry E Polyansky
Electron-proton transfer (EPT) from phenols to a triplet metal-to-ligand charge transfer (MLCT)-excited Ru polypyridine complex containing an uncoordinated nitrogen site, 1(T), can be described by a kinetic model that accounts for the H-bonding of 1(T) to phenol, 1(T) to solvent, and phenol to solvent. The latter plays a major role in the kinetic solvent effect and commonly precludes simultaneous determination of the EPT rate constant and 1(T)-phenol H-bonding constant. A number of these quantities previously reported for similar systems are shown to be in error due to inconsistent data analysis...
August 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28774524/clinical-profiles-and-surgical-outcomes-of-adult-esotropia
#18
Mikel Mikhail, Michael Flanders
OBJECTIVE: The aim of this study was to describe the clinical features and surgical outcomes of teenage and adult patients with esotropia undergoing strabismus surgery with adjustable sutures. METHODS: Seventy-three patients were included in this retrospective, cohort study. Patients were stratified into group 1 (35 with childhood-onset esotropia [CET]) and group 2 (38 with adult-onset esophoria-tropia [EPT]). Preoperative immediate, 2-week, and 4-6-month postoperative measurements of ocular alignment, as well as fusional testing, were performed...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28749240/epigenetic-dysregulation-of-the-erythropoietic-transcription-factor-klf1-and-the-%C3%AE-like-globin-locus-in-juvenile-myelomonocytic-leukemia
#19
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M Niemeyer, Christian Flotho
Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions in leukemic cells. Since the regulation of globin gene transcription is known to be under epigenetic control, we set out to study the relation of DNA methylation patterns at β-/γ-globin promoters, mRNA and protein expression of globins, and epigenetic modifications of genes encoding the globin-regulatory transcription factors BCL11A and KLF1 in nucleated erythropoietic precursor cells of patients with JMML...
July 27, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28715797/neurodevelopment-at-3-years-in-neonates-born-by-vaginal-delivery-versus-cesarean-section-at-26-weeks-of-gestation-retrospective-analysis-of-a-nationwide-registry-in-japan
#20
Takeshi Kimura, Masato Takeuchi, Takumi Imai, Shiro Tanaka, Koji Kawakami
BACKGROUND: A high proportion of extremely preterm (EPT) infants are born by cesarean section (CS). However, whether the mode of delivery is related to long-term neurodevelopment in these infants is unclear. OBJECTIVES: This study aimed to determine whether the mode of delivery is associated with mortality and long-term outcomes in EPT infants. METHODS: We analyzed data of the Neonatal Research Network in Japan (NRNJ), a population-based, nationwide registry...
July 14, 2017: Neonatology
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