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https://www.readbyqxmd.com/read/28805728/nano-charged-polypropylene-application-realistic-perspectives-for-enhancing-durability
#1
Carlo Naddeo, Luigi Vertuccio, Giuseppina Barra, Liberata Guadagno
Isotactic polypropylene/multi-walled carbon nanotube (iPP/MWCNTs) films have been exposed to accelerated weathering in a UV device for increasing times. The effect of UV irradiation on the structural and chemical changes has been investigated. The resistance to accelerated photooxidation of (iPP/MWCNTs) films has been compared to the photooxidation behaviour of unfilled polypropylene films with the same structural organization. The chemical and structural modifications resulting from photooxidation have been followed using infrared spectroscopy, calorimetric and diffractometric analysis...
August 14, 2017: Materials
https://www.readbyqxmd.com/read/28796699/serum-uric-acid-levels-and-hormone-therapy-type-a-retrospective-cohort-study-of-postmenopausal-women
#2
Jae H Jung, Gwan G Song, Young H Lee, Jae-Hoon Kim, Myung H Hyun, Sung J Choi
OBJECTIVE: Serum uric acid levels increase in postmenopausal women, but decrease when hormone therapy (HT) is administered. No study has, however, evaluated the effects of different types of HT on serum uric acid levels. We therefore examined whether estrogen therapy (ET), estrogen plus progestogen therapy (EPT), and tibolone use affected serum uric acid levels in this population. METHODS: We performed a retrospective cohort study of postmenopausal women. From 2005 to 2015, postmenopausal women who had undergone blood uric acid-level testing at least twice were enrolled...
August 7, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28792768/role-of-hydrogen-bonding-in-photoinduced-electron-proton-transfer-from-phenols-to-a-polypyridine-ru-complex-with-a-proton-accepting-ligand
#3
Sergei V Lymar, Mehmed Z Ertem, Anna Lewandowska-Andralojc, Dmitry E Polyansky
Electron-proton transfer (EPT) from phenols to a triplet metal-to-ligand charge transfer (MLCT)-excited Ru polypyridine complex containing an uncoordinated nitrogen site, 1(T), can be described by a kinetic model that accounts for the H-bonding of 1(T) to phenol, 1(T) to solvent, and phenol to solvent. The latter plays a major role in the kinetic solvent effect and commonly precludes simultaneous determination of the EPT rate constant and 1(T)-phenol H-bonding constant. A number of these quantities previously reported for similar systems are shown to be in error due to inconsistent data analysis...
August 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28774524/clinical-profiles-and-surgical-outcomes-of-adult-esotropia
#4
Mikel Mikhail, Michael Flanders
OBJECTIVE: The aim of this study was to describe the clinical features and surgical outcomes of teenage and adult patients with esotropia undergoing strabismus surgery with adjustable sutures. METHODS: Seventy-three patients were included in this retrospective, cohort study. Patients were stratified into group 1 (35 with childhood-onset esotropia [CET]) and group 2 (38 with adult-onset esophoria-tropia [EPT]). Preoperative immediate, 2-week, and 4-6-month postoperative measurements of ocular alignment, as well as fusional testing, were performed...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28749240/epigenetic-dysregulation-of-the-erythropoietic-transcription-factor-klf1-and-the-beta-like-globin-locus-in-juvenile-myelomonocytic-leukemia
#5
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M Niemeyer, Christian Flotho
Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions in leukemic cells. Since the regulation of globin gene transcription is known to be under epigenetic control, we set out to study the relation of DNA methylation patterns at β-/γ-globin promoters, mRNA and protein expression of globins, and epigenetic modifications of genes encoding the globin-regulatory transcription factors BCL11A and KLF1 in nucleated erythropoietic precursor cells of patients with JMML...
July 27, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28715797/neurodevelopment-at-3-years-in-neonates-born-by-vaginal-delivery-versus-cesarean-section-at-26-weeks-of-gestation-retrospective-analysis-of-a-nationwide-registry-in-japan
#6
Takeshi Kimura, Masato Takeuchi, Takumi Imai, Shiro Tanaka, Koji Kawakami
BACKGROUND: A high proportion of extremely preterm (EPT) infants are born by cesarean section (CS). However, whether the mode of delivery is related to long-term neurodevelopment in these infants is unclear. OBJECTIVES: This study aimed to determine whether the mode of delivery is associated with mortality and long-term outcomes in EPT infants. METHODS: We analyzed data of the Neonatal Research Network in Japan (NRNJ), a population-based, nationwide registry...
July 14, 2017: Neonatology
https://www.readbyqxmd.com/read/28714101/children-born-extremely-preterm-had-different-sleeping-habits-at-11-years-of-age-and-more-childhood-sleep-problems-than-term-born-children
#7
Kristine Marie Stangenes, Silje Kathrine Fevang, Jacob Grundt, Hilde Mjell Donkor, Trond Markestad, Mari Hysing, Irene Bircow Elgen, Bjørn Bjorvatn
AIM: This study explored whether extremely preterm (EPT) children had different sleep characteristics in childhood than children born at term, and how neurodevelopmental disabilities (NDD) affected sleep in children born EPT. METHODS: A Norwegian national cohort of 231 children born EPT from 1999-2000 and separate study data on 556 children born at term in 2001 were compared. Parental questionnaires mapped the children's current sleep habits at 11 years of age, namely the prevalence of sleep problems throughout childhood until this age and five categories of sleep problems...
July 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28712619/ethics-of-informed-consent-for-pragmatic-trials-with-new-interventions
#8
Shona Kalkman, Scott Y H Kim, Ghislaine J M W van Thiel, Diederick E Grobbee, Johannes J M van Delden
OBJECTIVES: Pragmatic trials evaluate the comparative benefits, risks, and burdens of health care interventions in real-world conditions. Such studies are now recognized as valuable to the perimarketing stage of drug development and evaluation, with early pragmatic trials (EPTs) being explored as a means to generate real-world evidence at the time of regulatory market approval. In this article, we present an analysis of the ethical issues involved in informed consent for EPTs, in light of the generally recognized concern that traditional ethical rules governing randomized clinical trials, such as lengthy informed consent procedures, could threaten the "real world" nature of such trials...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28708025/chlamydia-and-gonorrhea-screening-and-expedited-partner-therapy-ept-practices-of-college-student-health-centers
#9
Sara B Oswalt, Heather P Eastman-Mueller
OBJECTIVE: To examine college student health centers' practices related to STD screening and treatment over a five-year period. PARTICIPANTS: College student health centers (SHCs) that completed the ACHA Pap and STI Survey between 2010 and 2014. METHODS: Chi-square tests were conducted with Cramer's V providing a measure of association. RESULTS: Chlamydia screening of women under 25 years of age was a well-established practice...
July 14, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28706360/osteoporosis-prevention-and-management
#10
Muralidhar V Pai
Osteoporosis, defined by BMD at the hip or lumbar spine that is less than or equal to 2.5 standard deviations below the mean BMD of a young-adult reference population, is the most common bone disease in humans affecting both sexes and all races. It's a silent killer affecting the quality of life due to fractures and postural changes. In osteoporosis there is an imbalance between bone formation and bone resorption in favor of latter. Preventive measures and treatments are available to combat this evil. Counseling is the integral part of prevention as well as treatment of osteoporosis...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28699219/enzyme-prodrug-therapy-engineered-into-electrospun-fibers-with-embedded-liposomes-for-controlled-localized-synthesis-of-therapeutics
#11
Rona Chandrawati, Morten T J Olesen, Thatiane C C Marini, Gurpal Bisra, Anne Géraldine Guex, Marcelo G de Oliveira, Alexander N Zelikin, Molly M Stevens
Enzyme prodrug therapy (EPT) enables localized conversion of inert prodrugs to active drugs by enzymes. Performance of EPT necessitates that the enzyme remains active throughout the time frame of the envisioned therapeutic application. β-glucuronidase is an enzyme with historically validated performance in EPT, however it retains its activity in biomaterials for an insufficiently long period of time, typically not exceeding 7 d. Herein, the encapsulation of β-glucuronidase in liposomal subcompartments within poly(vinyl alcohol) electrospun fibers is reported, leading to the assembly of biocatalytically active materials with activity of the enzyme sustained over at least seven weeks...
July 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28696079/impact-of-protease-inhibitor-based-anti-retroviral-therapy-on-outcomes-for-hiv-kidney-transplant-recipients
#12
Deirdre Sawinski, Brittany A Shelton, Shikha Mehta, Rhiannon D Reed, Paul A MacLennan, Sally Gustafson, Dorry L Segev, Jayme E Locke
Excellent outcomes have been demonstrated among select HIV-positive kidney transplant (KT) recipients with well-controlled infection, but to date no national study has explored outcomes among HIV+ KT recipients by antiretroviral therapy (ART) regimen. IMS pharmacy fills (1/1/01 - 10/1/12) were linked with SRTR data. 332 recipients with pre- and post-transplant fills were characterized by ART at time of transplant as protease inhibitor (PI) or non-PI based ART (88 PI vs. 244 non-PI). Cox proportional hazards models were adjusted for recipient and donor characteristics...
July 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28685818/menopausal-hormone-therapy-and-risk-of-melanoma-do-estrogens-and-progestins-have-a-different-role
#13
Edoardo Botteri, Nathalie C Støer, Solveig Sakshaug, Sidsel Graff-Iversen, Siri Vangen, Solveig Hofvind, Giske Ursin, Elisabete Weiderpass
The association between use of menopausal hormone therapy (HT) and occurrence of skin malignant melanoma (SMM) is controversial. We investigated the issue in a nationwide cohort of 684,696 Norwegian women, aged 45-79 years, followed from 2004-2008. The study was based on linkage between Norwegian population registries. Multivariable Poisson regression models were used to estimate the effect of HT use, different HT types, routes of administration, and doses of estrogen and progestin on the risk of SMM. During the median follow-up of 4...
July 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28679170/evidence-for-substrate-influence-on-artificial-substrate-invertebrate-communities
#14
Iain D Phillips, Kate S Prestie
Cobble baskets are frequently used as a tool to measure differences in benthic macroinvertebrate communities between waterbodies; however, underlying differences in substrate type may influence the resultant colonization of baskets, misrepresenting communities. This study tests the hypothesis that cobble basket placement influences the resulting benthic macroinvertebrate community. Cobble basket arrays (n = 4) were deployed in Dog Lake, Saskatchewan, in 2011 (97 d) and 2012 (95 d) on cobble habitats and soft or sandy substrates ∼100 m apart...
June 29, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28677655/epithelial-to-pericyte-transition-in-cancer
#15
REVIEW
Jianrong Lu, Anitha K Shenoy
During epithelial-to-mesenchymal transition (EMT), cells lose epithelial characteristics and acquire mesenchymal properties. These two processes are genetically separable and governed by distinct transcriptional programs, rendering the EMT outputs highly heterogeneous. Our recent study shows that the mesenchymal products generated by EMT often express multiple pericyte markers, associate with and stabilize blood vessels to fuel tumor growth, thus phenotypically and functionally resembling pericytes. Therefore, some EMT events represent epithelial-to-pericyte transition (EPT)...
July 4, 2017: Cancers
https://www.readbyqxmd.com/read/28676386/prodrugs-in-medicinal-chemistry-and-enzyme-prodrug-therapies
#16
Raoul Walther, Jarkko Rautio, Alexander N Zelikin
Prodrugs are cunning derivatives of therapeutic agents designed to improve the pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is masked and is recovered within the human body upon bioconversion of the prodrug, a process that is typically mediated by enzymes. This concept is highly successful and a significant fraction of marketed therapeutic formulations is based on prodrugs. An advanced subset of prodrugs can be engineered such as to achieve site-specific bioconversion of the prodrug - to comprise the highly advantageous "enzyme prodrug therapy", EPT...
July 1, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28652692/combined-30-degree-bevel-up-and-down-technique-against-0-degree-phaco-tip-for-phacoemulsification-surgery-of-hard-cataracts
#17
Rajesh Subhash Joshi, Sonal Jayant Muley
PURPOSE: To evaluate the effective phaco time (EPT), cumulative dissipated energy (CDE) and nucleus emulsification time (NET) as phaco parameters with 0- and 30-degree phaco tip. PATIENTS AND METHODS: This prospective, interventional and observational case series included 294 patients scheduled for cataract removal by phacoemulsification technique. Patients with nuclear cataracts of grade 4 and 5 nuclear opalescence of Lens Opacities Classification System III were included in the study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28642374/behavioral-patterns-in-adolescents-born-at-23-to-25-weeks-of-gestation
#18
Maria Samuelsson, Antti Holsti, Marie Adamsson, Fredrik Serenius, Bruno Hägglöf, Aijaz Farooqi
BACKGROUND: This study examined mental health outcomes in extremely preterm children (EPT) born at 23 to 25 weeks of gestation between 1992 and 1998 at 2 Swedish tertiary care centers that offered regional and active perinatal care to all live-born EPT infants. METHODS: We assessed 132 (98%) of the 134 EPT survivors at 10 to 15 years of age alongside term-born controls. Behavioral and emotional problems were evaluated by using Achenbach's Child Behavior Checklist and Teacher Report Form and Conners' Parent and Teacher scales for attention-deficit/hyperactivity disorder...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28641559/a-stepwise-approach-for-the-isolation-and-the-identification-of-chemically-reactive-exofacial-protein-thiols
#19
Gabriele Candiani, Elisa Fasoli
The plasma membrane controls the selective internalization of (macro)molecules through different mechanisms, often relaying on specialized outward-facing carriers such as exofacial proteins thiols (EPTs). Although the interchange of critical thiols and disulphides between EPTs and exogenous cargoes is the first critical event, the identification of specific cell interactors remains to be thoroughly explored. We herein devise an enabling methodology for the isolation and identification of a subset of EPTs, named chemically reactive EPS, which are potential theranostic targets...
June 20, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28630814/normative-emotional-responses-to-behavior-analysis-jargon-or-how-not-to-use-words-to-win-friends-and-influence-people
#20
Thomas S Critchfield, Karla J Doepke, L Kimberly Epting, Amel Becirevic, Derek D Reed, Daniel M Fienup, Jamie L Kremsreiter, Cheryl L Ecott
It has been suggested that non-experts regard the jargon of behavior analysis as abrasive, harsh, and unpleasant. If this is true, excessive reliance on jargon could interfere with the dissemination of effective services. To address this often discussed but rarely studied issue, we consulted a large, public domain list of English words that have been rated by members of the general public for the emotional reactions they evoke. Selected words that behavior analysts use as technical terms were compared to selected words that are commonly used to discuss general science, general clinical work, and behavioral assessment...
June 2017: Behavior Analysis in Practice
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