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https://www.readbyqxmd.com/read/29146641/menopausal-hormone-therapy-and-colorectal-cancer-a-linkage-between-nationwide-registries-in-norway
#1
Edoardo Botteri, Nathalie C Støer, Solveig Sakshaug, Sidsel Graff-Iversen, Siri Vangen, Solveig Hofvind, Thomas de Lange, Vincenzo Bagnardi, Giske Ursin, Elisabete Weiderpass
OBJECTIVES: With the present study, we aimed to investigate the association between menopausal hormone therapy (HT) and risk of colorectal cancer (CRC). SETTING: Cohort study based on the linkage of Norwegian population-based registries. PARTICIPANTS: We selected 466822 Norwegian women, aged 55-79, alive and residing in Norway as of 1 January 2004, and we followed them from 2004 to 2008. Each woman contributed person-years at risk as non-user, current user and/or past HT user...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29144031/error-analysis-of-helmholtz-based-mr-electrical-properties-tomography
#2
Stefano Mandija, Alessandro Sbrizzi, Ulrich Katscher, Peter R Luijten, Cornelis A T van den Berg
PURPOSE: MR electrical properties tomography (MR-EPT) aims to measure tissue electrical properties by computing spatial derivatives of measured B1+ data. This computation is very sensitive to spatial fluctuations caused, for example, by noise and Gibbs ringing. In this work, the error arising from the computation of spatial derivatives using finite difference kernels (FD error) has been investigated. In relation to this FD error, it has also been investigated whether mitigation strategies such as Gibbs ringing correction and Gaussian apodization can be beneficial for conductivity reconstructions...
November 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29136548/wavelet-coherence-analysis-a-new-approach-to-distinguish-organic-and-functional-tremor-types
#3
G Kramer, A M M Van der Stouwe, N M Maurits, M A J Tijssen, J W J Elting
OBJECTIVE: To distinguish tremor subtypes using wavelet coherence analysis (WCA). WCA enables to detect variations in coherence and phase difference between two signals over time and might be especially useful in distinguishing functional from organic tremor. METHODS: In this pilot study, polymyography recordings were studied retrospectively of 26 Parkinsonian (PT), 26 functional (FT), 26 essential (ET), and 20 enhanced physiological (EPT) tremor patients. Per patient one segment of 20 s in duration, in which tremor was present continuously in the same posture, was selected...
October 14, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29113755/early-developmental-trajectories-of-preterm-infants
#4
Maya Yaari, David Mankuta, Ayelet Harel-Gadassi, Edwa Friedlander, Benjamin Bar-Oz, Smadar Eventov-Friedman, Nimrod Maniv, David Zucker, Nurit Yirmiya
BACKGROUND AND OBJECTIVES: Preterm infants are at risk for neuro-developmental impairments and atypical developmental trajectories. The aims of this study were to delineate early developmental trajectories of preterm and full-term infants. METHODS: The cognitive, language, and motor development of 149 infants - 19 extremely preterm (EPT), 34 very preterm (VPT), 57 moderately preterm (MPT), and 39 full-term (FT) - was evaluated using Mullen Scales at 1, 4, 8, 12, and 18 months...
November 4, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29113371/change-in-risk-of-breast-cancer-after-receiving-hormone-replacement-therapy-by-considering-effect-modifiers-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#5
Kang Wang, Feng Li, Li Chen, Yan-Mei Lai, Xiang Zhang, Hong-Yuan Li
We synthesize the current literatures and use the power of meta-analysis to examine trends on association between hormone replacement therapy (HRT) and the risk of breast cancer (BC). We performed a comprehensive literature search using PubMed, EMBASE, and Web of Science from their inception until Jan 2017. Prospective studies that provided adjusted risk estimates of HRT and BC risk were eligible. Categorical and dose-response meta-analyses followed the PRISMA were conducted using random effects model and restricted cubic spline model, respectively...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112594/sexual-activity-and-vaginal-symptoms-in-the-postintervention-phase-of-the-women-s-health-initiative-hormone-therapy-trials
#6
Margery Gass, Joseph Larson, Barbara Cochrane, JoAnn E Manson, Dorothy Lane, Vanessa Barnabei, Judith Ockene, Marcia L Stefanick, Charles Mouton
OBJECTIVE: To assess the impact of discontinuing oral hormone therapy (HT) on sexual activity, vaginal symptoms, and sexual activity components among participants in the estrogen-progestin therapy (EPT) and estrogen therapy (ET) trial of the Women's Health Initiative. METHODS: Surveys were sent postintervention to those who were still taking study pills and agreed to continue in the study when the trials were stopped. Comparisons between former HT and placebo users were accomplished with chi-square tests for categorical variables and t tests for continuous variables...
November 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29111243/spatiotemporal-scales-of-river-groundwater-interaction-the-role-of-local-interaction-processes-and-regional-groundwater-regimes
#7
Jannis Epting, Peter Huggenberger, Dirk Radny, Frederik Hammes, Juliane Hollender, Rebecca M Page, Stefanie Weber, Dominik Bänninger, Adrian Auckenthaler
Drinking water production in the vicinity of rivers not only requires the consideration of different spatiotemporal scales and settings of river-groundwater interaction processes, but also of local and regional scale groundwater regimes. Selected case studies in combination with field-experiments and the setup of high-resolution groundwater flow models enabled the investigation of the spatiotemporal development of microbial (classical fecal indicator bacteria and total cell counts) and selected organic micropollutants in riverine and regional groundwater for different hydrological settings, including low and high flow conditions...
October 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29083854/applications-of-photogating-and-time-resolved-spectroscopy-to-mechanistic-studies-of-hydrogenases
#8
Brandon L Greene, Gregory E Vansuch, Bryant C Chica, Michael W W Adams, R Brian Dyer
Rapid and facile redox chemistry is exemplified in nature by the oxidoreductases, the class of enzymes that catalyze electron transfer (ET) from a donor to an acceptor. The key role of oxidoreductases in metabolism and biosynthesis has imposed evolutionary pressure to enhance enzyme efficiency, pushing some toward the diffusion limit. Understanding the detailed molecular mechanisms of these highly optimized enzymes would provide an important foundation for the rational design of catalysts for multielectron chemistry, including fuel production...
October 30, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29066226/cast-nephropathy-and-deceptively-low-absolute-serum-free-light-chain-levels-resolution-of-a-challenging-case-and-systematic-review-of-the-literature
#9
Michael P Rassner, Maximilian Seidl, Ulrich Salzer, S Vincent Rajkumar, Thomas Epting, Ralph Wäsch, Elke Neumann-Haefelin, Monika Engelhardt
No abstract text is available yet for this article.
October 3, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29063658/physiological-augmentation-of-esophageal-distension-pressure-and-peristalsis-during-conditions-of-increased-esophageal-emptying-resistance
#10
G J Brink, W Y Lei, T I Omari, M M J Singendonk, J S Hung, T T Liu, C H Yi, C L Chen
BACKGROUND: Abdominal compression has been implemented as a provocative maneuver in high-resolution impedance manometry (HRIM) to "challenge" normal esophageal physiology with the aim of revealing abnormal motor patterns which may explain symptoms. In this study, we measured the effects of abdominal compression on esophageal functioning utilizing novel pressure-impedance parameters and attempted to identify differences between healthy controls and globus patients. METHODS: Twenty-two healthy volunteers (aged 23-32 years, 41% female) and 22 globus patients (aged 23-72 years, 68% female) were evaluated with HRIM using a 3...
October 24, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29054671/impacts-of-rapid-urbanization-on-the-water-quality-and-macroinvertebrate-communities-of-streams-a-case-study-in-liangjiang-new-area-china
#11
Kun Luo, Xuebin Hu, Qiang He, Zhengsong Wu, Hao Cheng, Zhenlong Hu, Asit Mazumder
Rapid urbanization in China has dramatically deteriorated the water quality of streams and threatening aquatic ecosystem health. This study aims to 1) assess the impacts of urbanization on water quality and macroinvertebrate composition and 2) address the question of how urbanization affects macroinvertebrate distribution patterns. Environmental variables over multispatial scales and macroinvertebrate community data were collected on April (dry season) and September (wet season) of 2014 and 2015 at 19 sampling sites, of which nine had a high urbanization level (HUL), six had moderate urbanization level (MUL) and four had low urbanization level (LUL), in the Liangjiang New Area...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29044058/femtosecond-laser-assisted-cataract-surgery-versus-2-2-mm-clear-corneal-phacoemulsification
#12
H Ranjini, Praveen R Murthy, Gowri J Murthy, Vinay R Murthy
PURPOSE: Phacoemulsification is the surgical procedure of choice for cataract, providing excellent visual and safety outcomes. Femtosecond laser-assisted cataract surgery (FLACS) is an addition to the surgical armamentarium. The study aims to compare the outcomes of FLACS using LenSx™ (Alcon Inc., USA) to standard 2.2 mm clear corneal phacoemulsification. Prospective case-control, comparative, interventional study was conducted in a tertiary care center. METHODS: In each group, 55 eyes of 55 patients underwent cataract surgery using either FLACS or conventional phacoemulsification (control group)...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29035208/an-efficient-integral-based-method-for-three-dimensional-mr-ept-and-the-calculation-of-the-rf-coil-induced-field
#13
Lei Guo, Jin Jin, Chunyi Liu, Feng Liu, Stuart Crozier
Magnetic resonance electrical property tomography (MR-EPT) has significant potential for the estimation of the electrical properties (EPs) of tissue, which are essential for the calculation of specific absorption rates (SAR), a critical safety factor requiring monitoring and controlling in applications of ultra-high field magnetic resonance imaging (MRI). In this paper, a novel, efficient method based on integral equations is proposed for the calculation of the EPs and the RF-coil induced field. An inverse problem framework is first constructed to include the forward problem operator, while the EPs are reconstructed by using a non-linear conjugate gradient method (NLCG)...
October 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28990000/extended-pancreatic-transection-for-secure-pancreatic-reconstruction-during-pancreaticoduodenectomy
#14
Eun-Kyoung Jwa, Shin Hwang
BACKGROUNDS/AIMS: Pancreaticoduodenectomy (PD) is associated with various surgical complications including healing failure of the pancreaticojejunostomy (PJ). This study intended to ensure blood supply to the pancreatic stump through extended pancreatic transection (EPT). METHODS: This study assessed whether EPT reduces PJ-associated complications and whether EPT is harmful on the remnant pancreatic function. The EPT group included 19 patients undergoing PD, pylorus-preserving PD (PPPD) or hepatopancreaticoduodenectomy...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28989329/probability-of-an-autism-diagnosis-by-gestational-age
#15
Ashley Darcy-Mahoney, Bonnie Minter, Melinda Higgins, Ying Guo, Bryan Williams, Lauren M Head Zauche, Katie Birth
Early preterm infants (EPT) (<33 6/7 weeks) are at increased risk for autism spectrum disorders (ASDs) but prevalence estimates vary widely across studies. Furthermore, there are very few studies addressing the association between late preterm (LPT) births (34-36 6/7 weeks) and ASDs. To address the question of whether LPT infants carry the same risk for ASDs as full-term infants, this study aimed to estimate the relative probability of an ASD diagnosis using Bayes rule. A retrospective cohort analysis of 406 children was undertaken to look at gestational age, ASDs, and birth history...
December 2016: Newborn and Infant Nursing Reviews: NAINR
https://www.readbyqxmd.com/read/28975776/menopause-and-hormone-replacement-therapy-the-2017-recommendations-of-the-italian-menopause-society
#16
Marco Gambacciani, Nicoletta Biglia, Angelo Cagnacci, Costantino DI Carlo, Salvatore Caruso, Ettore Cicinelli, Vincenzo DE Leo, Manuela Farris, Alessandro Gambera, Secondo Guaschino, Antonio Lanzone, Anna M Paoletti, Novella Russo, Franco Vicariotto, Paola Villa, Annibale Volpe
In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society, The International Menopause Society, The International Osteoporosis Foundation and The North American Menopause Society)...
October 3, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28928213/cell-cycle-inhibition-to-treat-sleeping-sickness
#17
Conrad L Epting, Brian T Emmer, Nga Y Du, Joann M Taylor, Ming Y Makanji, Cheryl L Olson, David M Engman
African trypanosomiasis is caused by infection with the protozoan parasite Trypanosoma brucei During infection, this pathogen divides rapidly to high density in the bloodstream of its mammalian host in a manner similar to that of leukemia. Like all eukaryotes, T. brucei has a cell cycle involving the de novo synthesis of DNA regulated by ribonucleotide reductase (RNR), which catalyzes the conversion of ribonucleotides into their deoxy form. As an essential enzyme for the cell cycle, RNR is a common target for cancer chemotherapy...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28916493/cell-mediated-enzyme-prodrug-cancer-therapies
#18
Rachael Mooney, Asma Abdul Majid, Jennifer Batalla, Alexander J Annala, Karen S Aboody
Cell-directed gene therapy is a promising new frontier for the field of targeted cancer therapies. Here we discuss the current pre-clinical and clinical use of cell-mediated enzyme prodrug therapy (EPT) directed against solid tumors and avenues for further development. We also discuss some of the challenges encountered upon translating these therapies to clinical trials. Upon sufficient development, cell-mediated enzyme prodrug therapy has the potential to maximize the distribution of therapeutic enzymes within the tumor environment, localizing conversion of prodrug to active drug at the tumor sites thereby decreasing off-target toxicities...
September 13, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28912968/bimanual-microincision-cataract-surgery-versus-coaxial-microincision-cataract-surgery-a-meta-analysis-of-randomized-controlled-trials-and-cohort-studies
#19
Chenxi Fu, Naipin Chu, Xiaoning Yu, Ke Yao
PURPOSE: This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision cataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). METHODS: Three databases were searched for papers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative outcomes were included in the final meta-analysis: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), mean surgery time, best-corrected visual acuity (BCVA), central corneal thickness (CCT), and increased CCT...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28890971/quantitative-interpretation-of-impedance-spectroscopy-data-on-porous-lsm-electrodes-using-x-ray-computed-tomography-and-bayesian-model-based-analysis
#20
Giuseppe F Brunello, William K Epting, Juwana de Silva, Paul A Salvador, Shawn Litster, Harry O Finklea, Yueh-Lin Lee, Kirk R Gerdes, David S Mebane
It is broadly understood that strontium-doped lanthanum manganate (LSM) cathodes for solid oxide fuel cells (SOFCs) have two pathways for the reduction of oxygen: a surface-mediated pathway culminating in oxygen incorporation into the electrolyte at the triple-phase boundary (TPB), and a bulk-mediated pathway involving oxygen transfer across the electrode-electrolyte interface. Patterned electrode and thin film experiments have shown that both pathways are active in LSM. Porous electrode geometries more commonly found in SOFCs have not been amenable for precise measurement of active electrode width because of the difficulty in precisely measuring the electrode geometry...
September 27, 2017: Physical Chemistry Chemical Physics: PCCP
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