Kenyatta C M F Viel, Sreeja Parameswaran, Omer A Donmez, Carmy R Forney, Matthew R Hass, Cailing Yin, Sydney H Jones, Hayley K Prosser, Arame A Diouf, Olivia E Gittens, Lee E Edsall, Xiaoting Chen, Hope Rowden, Katelyn A Dunn, Rui Guo, Andrew VonHandorf, Merrin Man Long Leong, Kevin Ernst, Kenneth M Kaufman, Lucinda P Lawson, Ben Gewurz, Bo Zhao, Leah C Kottyan, Matthew T Weirauch
BACKGROUND: There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr Nuclear Antigen 2 (EBNA2). While type 1 EBNA2 is known to interact with human transcription factors (hTFs) such as RBPJ, EBF1, and SPI1 (PU.1), type 2 EBNA2 shares only ~ 50% amino acid identity with type 1 and thus may have distinct binding partners, human genome binding locations, and functions...
March 12, 2024: BMC Genomics