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E Signoriello, M Cirillo, G Puoti, G Signoriello, A Negro, E Koci, M A B Melone, A Rapacciuolo, G Maresca, G Lus
OBJECTIVES: To investigate a possible association between isolated white matter lesions suggestive of demyelinating disease in magnetic resonance imaging (MRI) and patent foramen ovale (PFO) evidence in migraine patients, with or without aura. MATERIALS: 31 migraine patients, 28 females and 3 males, with MRI evidence of white matter lesions suggestive of demyelinating disease according to the Barkhof Criteria. All patients underwent further diagnostics including lumbar puncture, autoimmunity panel and cardiological evaluation to detect the presence of PFO...
July 15, 2018: Journal of the Neurological Sciences
Shailesh B Raval, Cynthia A Britton, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay S Gorantla, Tamer S Ibrahim
OBJECTIVE: The purpose of this study was to explore the efficacy of Ultra-high field [UHF] 7 Tesla [T] MRI as compared to 3T MRI in non-contrast enhanced [nCE] imaging of structural anatomy in the elbow, forearm, and hand [upper extremity]. MATERIALS AND METHOD: A wide range of sequences including T1 weighted [T1] volumetric interpolate breath-hold exam [VIBE], T2 weighted [T2] double-echo steady state [DESS], susceptibility weighted imaging [SWI], time-of-flight [TOF], diffusion tensor imaging [DTI], and diffusion spectrum imaging [DSI] were optimized and incorporated with a radiofrequency [RF] coil system composed of a transverse electromagnetic [TEM] transmit coil combined with an 8-channel receive-only array for 7T upper extremity [UE] imaging...
2017: PloS One
Hui-Jie Qiao, Zhen-Zhi Li, Li-Ming Wang, Wei Sun, Jin-Chao Yu, Bin Wang
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission in patients with acute ischemic stroke (AIS). METHODS: The study population comprised consecutive patients with an AIS diagnosis who had been referred to our hospital between January 2015 and June 2016. The severity of stroke was evaluated by the National Institutes of Health Stroke Scale (NIHSS) at admission...
June 15, 2017: Journal of Neuroimmunology
Monica Lara-Almunia, Javier Hernandez-Vicente
BACKGROUND: We describe the carrying out of our open door laminoplasty technique by reproducing a posterior vertebral arch using a local originating autologous bony graft and titanium plates. METHODS: We designed a prospective study and present our first 16 patients. The clinical results were evaluated with the JOA score, Nurick scale and the VAS. The functional and radiological evaluation was performed with radiographs, CT and MRI, and the measurements of the dimensions of the spinal canal were carried out with the MIPAV programme ( Johns Hopkins University)...
2017: International Journal of Spine Surgery
Chun-Yuan Ting, Philip G McQueen, Nishith Pandya, Evan S McCreedy, Matthew McAuliffe, Chi-Hon Lee
In many regions of the central nervous systems, such as the fly optic lobes and the vertebrate cortex, synaptic circuits are organized in layers and columns to facilitate brain wiring during development and information processing in developed animals. Postsynaptic neurons elaborate dendrites in type-specific patterns in specific layers to synapse with appropriate presynaptic terminals. The fly medulla neuropil is composed of 10 layers and about 750 columns; each column is innervated by dendrites of over 38 types of medulla neurons, which match with the axonal terminals of some 7 types of afferents in a type-specific fashion...
March 23, 2017: Journal of Visualized Experiments: JoVE
Shadi Yaghi, Charlotte Herber, Amelia K Boehme, Howard Andrews, Joshua Z Willey, Sara K Rostanski, Matthew Siket, Mahesh V Jayaraman, Ryan A McTaggart, Karen L Furie, Randolph S Marshall, Ronald M Lazar, Bernadette Boden-Albala
BACKGROUND: Prior studies have shown a correlation between the National Institutes of Health Stroke Scale (NIHSS) and stroke volume on diffusion weighted imaging (DWI); data are more limited in patients with minor stroke. We sought to determine the association between DWI lesion(s) volume and the (1) total NIHSS score and (2) NIHSS component scores in patients with minor stroke. METHODS: We included all patients with minor stroke (NIHSS 0-5) enrolled in the Stroke Warning Information and Faster Treatment study...
July 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Ivica Kopriva, Wei Ju, Bin Zhang, Fei Shi, Dehui Xiang, Kai Yu, Ximing Wang, Ulas Bagci, Xinjian Chen
In this paper, we propose a novel method for single-channel blind separation of nonoverlapped sources and, to the best of our knowledge, apply it for the first time to automatic segmentation of lung tumors in positron emission tomography (PET) images. Our approach first converts a 3-D PET image into a pseudo-multichannel image. Afterward, regularization free sparseness constrained non-negative matrix factorization is used to separate tumor from other tissues. By using complexity based criterion, we select tumor component as the one with minimal complexity...
November 2017: IEEE Journal of Biomedical and Health Informatics
Won-Jin Moon, Ju-Yeon Park, Won-Sung Yun, Ji Yeong Jeon, Yeon Sil Moon, Heejin Kim, Ki-Chang Kwak, Jong-Min Lee, Seol-Heui Han
OBJECTIVE: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. MATERIALS AND METHODS: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
David P Bray, Jason A Ellis, Sean D Lavine, Philip M Meyers, E Sander Connolly
BACKGROUND: Antiplatelet medication use is associated with worsened outcome after angiogram-negative subarachnoid hemorrhage (SAH). It has been hypothesized that these worsened outcomes may be the result of an association between antiplatelet medication use and increased hemorrhage volumes after angiogram-negative SAH. To test this hypothesis, we performed volumetric analysis of computed tomography (CT)-defined hemorrhage after angiogram-negative SAH. METHODS: This was a retrospective analysis of patients presenting with nontraumatic, angiogram-negative SAH in the Columbia University Subarachnoid Hemorrhage Outcomes database between 2000 and 2013...
October 2016: World Neurosurgery
Renata Conforti, Mario Cirillo, Angela Sardaro, Giuseppina Caiazzo, Alberto Negro, Antonella Paccone, Rosaria Sacco, Maddalena Sparaco, Antonio Gallo, Luigi Lavorgna, Gioacchino Tedeschi, Sossio Cirillo
INTRODUCTION: Fatigue (F) is a common, inexplicable, and disabling symptom in multiple sclerosis (MS) patients. The purpose of this study was to evaluate a possible correlation between fatigue and morpho-volumetric features and site of dilated perivascular spaces (dPS), visible on 3T magnetic resonance (MR) in fatigued multiple sclerosis patients (FMS). METHODS: We studied 82 relapsing remitting (RR) FMS patients and 43 HC, matched for age, sex, and education. F was assessed by the Fatigue Severity Scale (FSS)...
September 2016: Neuroradiology
Shantell C Nolen, Brian Lee, Shruti Shantharam, Hon J Yu, Lydia Su, John Billimek, Daniela A Bota
Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration over time in hippocampal specific cognitive tasks was shown in patients receiving bevacizumab in addition to radiation and temozolomide for a longer period of time (RTOG 0825). The rate of hippocampal atrophy in patients treated with radiation and temozolomide followed by bevacizumab is not yet determined, and is the goal of the present study...
September 2016: Journal of Neuro-oncology
Shunxing Bao, Stephen M Damon, Bennett A Landman, Aniruddha Gokhale
Adopting high performance cloud computing for medical image processing is a popular trend given the pressing needs of large studies. Amazon Web Services (AWS) provide reliable, on-demand, and inexpensive cloud computing services. Our research objective is to implement an affordable, scalable and easy-to-use AWS framework for the Java Image Science Toolkit (JIST). JIST is a plugin for Medical-Image Processing, Analysis, and Visualization (MIPAV) that provides a graphical pipeline implementation allowing users to quickly test and develop pipelines...
February 27, 2016: Proceedings of SPIE
H Alex Choi, Suhas S Bajgur, Wesley H Jones, Jude P J Savarraj, Sang-Bae Ko, Nancy J Edwards, Tiffany R Chang, Georgene W Hergenroeder, Mark J Dannenbaum, P Roc Chen, Arthur L Day, Dong H Kim, Kiwon Lee, James C Grotta
BACKGROUND: Global cerebral edema (GCE) is a manifestation of early brain injury (EBI) after subarachnoid hemorrhage (SAH) and is an independent risk factor for poor outcome. The lack of a quantitative method to measure GCE limits the study of its pathophysiology. The goal of this study is to develop a quantitative surrogate marker that represents GCE after SAH. METHODS: Patients with spontaneous SAH were enrolled into a prospective observational database. Initial CT scans were graded for GCE using established qualitative criteria...
August 2016: Neurocritical Care
Ryan Patrick Christensen, Alexandra Bokinsky, Anthony Santella, Yicong Wu, Javier Marquina-Solis, Min Guo, Ismar Kovacevic, Abhishek Kumar, Peter W Winter, Nicole Tashakkori, Evan McCreedy, Huafeng Liu, Matthew McAuliffe, William Mohler, Daniel A Colón-Ramos, Zhirong Bao, Hari Shroff
The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because of technical difficulties associated with embryo movement in late embryogenesis. We present open-source untwisting and annotation software (
December 3, 2015: ELife
Daniel Haak, Charles-E Page, Thomas M Deserno
The digital imaging and communications in medicine (DICOM) protocol is the leading standard for image data management in healthcare. Imaging biomarkers and image-based surrogate endpoints in clinical trials and medical registries require DICOM viewer software with advanced functionality for visualization and interfaces for integration. In this paper, a comprehensive evaluation of 28 DICOM viewers is performed. The evaluation criteria are obtained from application scenarios in clinical research rather than patient care...
April 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Rajat Dhar, Kristy Yuan, Tobias Kulik, Yasheng Chen, Laura Heitsch, Hongyu An, Andria Ford, Jin-Moo Lee
BACKGROUND: Malignant cerebral edema (CED) complicates at least 20 % of large hemispheric infarcts (LHI) and may result in neurological deterioration or death. Midline shift (MLS) is a standard but crude measure of edema severity. We propose that volumetric analysis of shifts in cerebrospinal fluid (CSF) over time provides a reliable means of quantifying the spectrum of edema severity after LHI. METHODS: We identified 38 patients from 2008 to 2014 with NIHSS ≥8, baseline CT <6 h after stroke onset, at least 1 follow-up (FU) CT, and no parenchymal hematoma...
June 2016: Neurocritical Care
Benjamin Reiss, Lindsay Smithen, Sam Mansour
PURPOSE: Transient vision loss is a poorly understood complication of ocriplasmin injection. METHODS: The authors performed a retrospective medical records review of consecutive patients who received ocriplasmin for the treatment of vitreomacular adhesion at The George Washington University Department of Ophthalmology and the Virginia Retinal Center from January 1, 2013, to March 1, 2014, and who had at least 28 days of follow-up. Ellipsoid zone loss on optical coherence tomography was analyzed using the National Institutes of Health's Medical Imaging, Processing, Analysis, and Visualization (MIPAV) software...
June 2015: Retina
Kaustav Nandy, Jusub Kim, Dean P McCullough, Matthew McAuliffe, Karen J Meaburn, Terry P Yamaguchi, Prabhakar R Gudla, Stephen J Lockett
Image analysis is vital for extracting quantitative information from biological images and is used extensively, including investigations in developmental biology. The technique commences with the segmentation (delineation) of objects of interest from 2D images or 3D image stacks and is usually followed by the measurement and classification of the segmented objects. This chapter focuses on the segmentation task and here we explain the use of ImageJ, MIPAV (Medical Image Processing, Analysis, and Visualization), and VisSeg, three freely available software packages for this purpose...
2014: Methods in Molecular Biology
Renata Conforti, Mario Cirillo, Pietro Paolo Saturnino, Antonio Gallo, Rosaria Sacco, Alberto Negro, Antonella Paccone, Giuseppina Caiazzo, Alvino Bisecco, Simona Bonavita, Sossio Cirillo
PURPOSE: The aim of this study was to assess differences in the presence, size, number and site of dilated cerebral Virchow-Robin spaces (VRSd) between patients with multiple sclerosis (MS) in the inactive phase and healthy controls, and between MS patients with disabling (MSd) or nondisabling (MSnd) disease. MATERIALS AND METHODS: The study was performed by retrospectively analysing the 3 T magnetic resonance studies of 40 MS patients and 30 healthy subjects (matched for age, education and gender)...
June 2014: La Radiologia Medica
Haitham M Hussein, Nauman A Tariq, Yuko Y Palesch, Adnan I Qureshi
BACKGROUND AND PURPOSE: The reliability of hematoma volume (HV) measurement using the ABC/2 method in multicenter clinical trials is unknown. We determined the accuracy of ABC/2 method as an on-site test in comparison with the gold standard central HV-assessment and semiautomatic HV-assessment. Method- We analyzed data from an acute intracerebral hemorrhage multicenter clinical trial. HV was measured by site investigators to determine enrollment eligibility (<60 cm(3)) using the ABC/2 method (on-site HV), and independently by the core-imaging laboratory using computer-based analysis (Medical Image Processing, Analysis, and Visualization [MIPAV] HV)...
January 2013: Stroke; a Journal of Cerebral Circulation
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