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Peroxisome proliferator activator receptor gamma AND leukemia

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https://www.readbyqxmd.com/read/27635203/effects-of-valproic-acid-and-pioglitazone-on-cell-cycle-progression-and-proliferation-of-t-cell-acute-lymphoblastic-leukemia-jurkat-cells
#1
Marie Saghaeian Jazi, Saeed Mohammadi, Yaghoub Yazdani, Sima Sedighi, Ali Memarian, Mehrdad Aghaei
OBJECTIVES: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor. Administration of chemical compounds influencing apoptosis and T cell development has been discussed as promising novel therapeutic strategies. Valproic acid (VPA) as a recently emerged anti-neoplastic histone deacetylase (HDAC) inhibitor and pioglitazone (PGZ) as a high-affinity peroxisome proliferator-activated receptor-gamma (PPARγ) agonist have been shown to induce apoptosis and cell cycle arrest in different studies...
July 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27545215/ppar-gamma-in-overcoming-kinase-resistance-in-chronic-myeloid-leukemia
#2
B Yousefi, V Shafiei-Irannejad, A Azimi, N Samadi, N Zarghami
Peroxisome proliferator-activated receptor gamma (PPARγ) plays key roles in regulating cellular differentiation, proliferation and apoptosis pathways. As such, they are considered promising targets for anticancer drug development, especially for breast cancer, multiple myeloma and hematologic malignancies. Chronic myeloid leukemia (CML) is a myeloproliferative disorder arising from an oncogenic Bcr-Abl tyrosine kinase. Inhibitors of this oncogene by small molecules such as imatinib are effective only in 75% of the patient's population...
2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27428427/subcellular-compartmentalization-of-docking-protein-1-contributes-to-progression-in-colorectal-cancer
#3
Teresa Friedrich, Michaela Söhn, Tobias Gutting, Klaus-Peter Janssen, Hans-Michael Behrens, Christoph Röcken, Matthias P A Ebert, Elke Burgermeister
Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human cancers. Small DOK1 variants remain in cells of solid tumors and leukemias, albeit, their functions are elusive. To assess the so far unknown role of DOK1 in colorectal cancer (CRC), we generated DOK1 mutants which mimic the domain structure and subcellular distribution of DOK1 protein variants in leukemia patients. We found that cytoplasmic DOK1 activated peroxisome-proliferator-activated-receptor-gamma (PPARγ) resulting in inhibition of the c-FOS promoter and cell proliferation, whereas nuclear DOK1 was inactive...
June 2016: EBioMedicine
https://www.readbyqxmd.com/read/27291250/hydroxy-cinnamic-acid-derivatives-as-partial-ppar%C3%AE-agonists-in-silico-studies-synthesis-and-biological-characterization-against-chronic-myeloid-leukemia-cell-line-k-562
#4
Hardik Joshi, Kavita Marulkar, Vikram Gota, C S Ramaa
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates the expression of many genes relevant to carcinogenesis. By analogy to selective estrogen receptor modulator for treatment of cancer, selective or partial PPARγ agonists are considered clinically important for chemotherapy of cancer. A series of p-coumaric (3a-3y) and ferulic acid (4a-4y) derivatives were designed as docked and virtually studied for their molecular properties. Synthesized derivatives were assessed to check their effect on non-transformed hepatocytes and further evaluated for their anti-proliferative potential on K-562...
June 6, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27150726/microrna-128-inhibition-attenuates-myocardial-ischemia-reperfusion-injury-induced-cardiomyocyte-apoptosis-by-the-targeted-activation-of-peroxisome-proliferator-activated-receptor-gamma
#5
Xiao Cong Zeng, Lang Li, Hong Wen, Qi Bi
The aim of the present study was to investigate the effects of microRNA (miR)-128 inhibition on the targeted activation of peroxisome proliferator-activated receptor gamma (PPARG) and on cardiomyocyte apoptosis induced by myocardial ischemia/reperfusion (I/R) injury. In vitro, the expression of PPARG was detected by reverse transcription-quantitative polymerase chain reaction and western blotting in neonatal rat ventricular myocytes (NRVMs) and HEK293 cells transfected with the mimics or inhibitors of miR‑128 or control RNA...
July 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26671528/evodiamine-inhibits-the-proliferation-of-leukemia-cell-line-k562-by-regulating-peroxisome-proliferators-activated-receptor-gamma-ppar%C3%AE-pathway
#6
Chengming Sun, Guili Zhang, Shuping Luan, Caifu Luan, Huiyuan Shao, Fei Dong, Xuena Liu
Evodiamine, a quinolone alkaloid, is one of the major bioactive compounds of Evodia rutaecarpa Bentham (Rutaceae). It exhibits excellent biological activities, especially the anticancer activity. This study aims to investigate the effect of evodiamine on the proliferation of leukemia cell line K562 and to explore the underlying mechanism. The effect of evodiamine on K562 cells proliferation was analyzed by trypan blue dye exclusion assay and MTT assay. The expression levels of peroxisome proliferators-activated receptor gamma (PPARγ), cyclin D1, and p21 were detected by western blot assay...
August 2016: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/26407237/car-suppresses-hepatic-gluconeogenesis-by-facilitating-the-ubiquitination-and-degradation-of-pgc1%C3%AE
#7
Jie Gao, Jiong Yan, Meishu Xu, Songrong Ren, Wen Xie
The constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) are master regulators of drug metabolism and gluconeogenesis, respectively. In supporting the cross talk between drug metabolism and energy metabolism, activation of CAR has been shown to suppress hepatic gluconeogenesis and ameliorate hyperglycemia in vivo, but the underlying molecular mechanism remains elusive. In this study, we demonstrated that CAR suppressed hepatic gluconeogenic gene expression through posttranslational regulation of the subcellular localization and degradation of PGC1α...
November 2015: Molecular Endocrinology
https://www.readbyqxmd.com/read/26331539/erosion-of-the-chronic-myeloid-leukaemia-stem-cell-pool-by-ppar%C3%AE-agonists
#8
Stéphane Prost, Francis Relouzat, Marc Spentchian, Yasmine Ouzegdouh, Joseph Saliba, Gérald Massonnet, Jean-Paul Beressi, Els Verhoeyen, Victoria Raggueneau, Benjamin Maneglier, Sylvie Castaigne, Christine Chomienne, Stany Chrétien, Philippe Rousselot, Philippe Leboulch
Whether cancer is maintained by a small number of stem cells or is composed of proliferating cells with approximate phenotypic equivalency is a central question in cancer biology. In the stem cell hypothesis, relapse after treatment may occur by failure to eradicate cancer stem cells. Chronic myeloid leukaemia (CML) is quintessential to this hypothesis. CML is a myeloproliferative disorder that results from dysregulated tyrosine kinase activity of the fusion oncoprotein BCR-ABL. During the chronic phase, this sole genetic abnormality (chromosomal translocation Ph(+): t(9;22)(q34;q11)) at the stem cell level causes increased proliferation of myeloid cells without loss of their capacity to differentiate...
September 17, 2015: Nature
https://www.readbyqxmd.com/read/25368164/c-abl-tyrosine-kinase-promotes-adipocyte-differentiation-by-targeting-ppar-gamma-2
#9
COMPARATIVE STUDY
Rom Keshet, Zina Bryansker Kraitshtein, Matan Shanzer, Julia Adler, Nina Reuven, Yosef Shaul
Adipocyte differentiation, or adipogenesis, is a complex and highly regulated process. A recent proteomic analysis has predicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a putative key regulator of adipogenesis, but the underlying mechanism remained obscure. We found that c-Abl was activated during the early phase of mouse 3T3-L1 preadipocyte differentiation. Moreover, c-Abl activity was essential and its inhibition blocked differentiation to mature adipocytes. c-Abl directly controlled the expression and activity of the master adipogenic regulator peroxisome proliferator-activator receptor gamma 2 (PPARγ2)...
November 18, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/24569594/regulation-of-mkl1-via-actin-cytoskeleton-dynamics-drives-adipocyte-differentiation
#10
Hiroyuki Nobusue, Nobuyuki Onishi, Takatsune Shimizu, Eiji Sugihara, Yoshinao Oki, Yuko Sumikawa, Tatsuyuki Chiyoda, Koichi Akashi, Hideyuki Saya, Koichiro Kano
Cellular differentiation is regulated through activation and repression of defined transcription factors. A hallmark of differentiation is a pronounced change in cell shape, which is determined by dynamics of the actin cytoskeleton. Here we show that regulation of the transcriptional coactivator MKL1 (megakaryoblastic leukemia 1) by actin cytoskeleton dynamics drives adipocyte differentiation mediated by peroxisome proliferator-activated receptor γ (PPARγ), a master transcriptional regulator of adipogenesis...
2014: Nature Communications
https://www.readbyqxmd.com/read/23628590/dual-effects-of-peroxisome-proliferator-activated-receptor-%C3%AE-on-embryonic-stem-cell-self-renewal-in-presence-and-absence-of-leukemia-inhibitory-factor
#11
Maryam Peymani, Ali Ghoochani, Kamran Ghaedi, Fereshteh Karamali, Khadijeh Karbalaie, Abbas Kiani-Esfahani, Farzaneh Rabiee, Mohammad Hossein Nasr-Esfahani, Hossein Baharvand
The aim of this study was to evaluate the influence of peroxisome proliferator-activated receptor γ (PPARγ) on self-renewal of mouse embryonic stem cells (mESCs) in the presence and absence of leukemia inhibitory factor (LIF). We demonstrated that in the presence of LIF, the activation of PPARγ by Rosiglitazone led to an increased proliferation of mESCs whereas PPARγ antagonist (GW9662) reversed this effect. Additionally, upon PPARγ activation, LIF increased PPARγ expression and resulted in the degradation of suppressor of cytokine signaling 3 (SOCS3), an important negative regulator of LIF/signal transducers and activators of transcription 3 (STAT3)-pathway...
April 2013: European Journal of Cell Biology
https://www.readbyqxmd.com/read/23389992/identification-of-lrp16-as-a-negative-regulator-of-insulin-action-and-adipogenesis-in-3t3-l1-adipocytes
#12
L Zang, B Xue, Z Lu, X Li, G Yang, Q Guo, J Ba, X Zou, J Dou, J Lu, C Pan, Y Mu
Leukemia related protein 16 (LRP16) was first cloned from acute myeloid leukemia cells in our laboratory. In the present study, we sought to investigate the role of LRP16 in insulin action and sensitivity, using LRP16-depleted and -overexpressing 3T3-L1 cells. LRP16 silencing resulted in a reduction of the expression and secretion of tumor necrosis factor-alpha (TNF-α) and a concomitant increase in the expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ). Moreover, LRP16 depletion promoted insulin-induced glucose uptake and adipocyte differentiation of 3T3-L1 cells...
May 2013: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/23334894/targeting-ggtase-i-activates-rhoa-increases-macrophage-reverse-cholesterol-transport-and-reduces-atherosclerosis-in-mice
#13
Omar M Khan, Murali K Akula, Kristina Skålen, Christin Karlsson, Marcus Ståhlman, Stephen G Young, Jan Borén, Martin O Bergo
BACKGROUND: Statins have antiinflammatory and antiatherogenic effects that have been attributed to inhibition of RHO protein geranylgeranylation in inflammatory cells. The activity of protein geranylgeranyltransferase type I (GGTase-I) is widely believed to promote membrane association and activation of RHO family proteins. However, we recently showed that knockout of GGTase-I in macrophages activates RHO proteins and proinflammatory signaling pathways, leading to increased cytokine production and rheumatoid arthritis...
February 19, 2013: Circulation
https://www.readbyqxmd.com/read/22677017/peroxisome-proliferator-activated-receptor-activation-increases-imatinib-uptake-and-killing-of-chronic-myeloid-leukemia-cells
#14
Lihui Wang, Athina Giannoudis, Gemma Austin, Richard E Clark
Low pretreatment expression of the imatinib uptake transporter human organic cation transporter 1 (hOCT1) is associated with inferior complete cytogenetic response rates, progression-free survival, and overall survival in imatinib-treated chronic myeloid leukemia (CML). Upregulation of hOCT1 can therefore increase the uptake of imatinib. The hOCT1 gene is transactivated by hepatocyte nuclear factor 4α in human liver, and peroxisome proliferator-activated receptors (PPAR) α and γ activation increases OCT1 expression in mouse hepatocytes...
October 2012: Experimental Hematology
https://www.readbyqxmd.com/read/22152244/-peroxisome-proliferator-activated-receptor-gamma-activation-and-overexpression-prevent-hepatocellular-apoptosis-of-nutritional-fibrotic-steatohepatitis-in-mice
#15
Yue-min Nan, Fang Han, Ling-bo Kong, Ya Li, Rong-qi Wang, Su-xian Zhao
OBJECTIVE: To elucidate the effect of targeted gene modulation of peroxisome proliferator activated receptor gamma (PPARg) on hepatocellular apoptosis in nutritional fibrotic steatohepatitis in mice. C57BL/6J mice were fed with high fat, methionine-choline deficient (MCD) diet for 8 weeks to induce fibrotic steatohepatitis. Mice fed the MCD diet were treated with adenovirus carrying PPARg (Ad-PPARg), adenovirus-beta-galactosidase (Ad-LacZ), Ad-PPARg plus PPARg agonist rosiglitazone, or PPARg antagonist 2-chloro-5-nitro- benzanilide (GW9662), respectively...
July 2011: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/22140576/peroxisome-proliferator-activated-receptor-gamma-agonists-suppress-tissue-factor-overexpression-in-rat-balloon-injury-model-with-paclitaxel-infusion
#16
Jun-Bean Park, Baek-Kyung Kim, Yoo-Wook Kwon, Dominik N Muller, Hyun-Chae Lee, Seock-Won Youn, Young-Eun Choi, Sae-Won Lee, Han-Mo Yang, Hyun-Jai Cho, Kyung Woo Park, Hyo-Soo Kim
The role and underlying mechanisms of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, on myocardial infarction are poorly understood. We investigated the effects of this PPAR-γ agonist on the expression of tissue factor (TF), a primary molecule for thrombosis, and elucidated its underlying mechanisms. The PPAR-γ agonist inhibited TF expression in response to TNF-α in human umbilical vein endothelial cells, human monocytic leukemia cell line, and human umbilical arterial smooth muscle cells...
2011: PloS One
https://www.readbyqxmd.com/read/22124178/telmisartan-ameliorates-lipopolysaccharide-induced-innate-immune-response-through-peroxisome-proliferator-activated-receptor-%C3%AE-activation-in-human-monocytes
#17
Tao Pang, Julius Benicky, Juan Wang, Martina Orecna, Enrique Sanchez-Lemus, Juan M Saavedra
OBJECTIVE: Angiotensin II type 1 receptor (AT1) blockers (ARBs) reduce the bacterial endotoxin lipopolysaccharide (LPS)-induced innate immune response in human circulating monocytes expressing few AT1. To clarify the mechanisms of anti-inflammatory effects of ARBs with different peroxisome proliferator-activated receptor-γ (PPARγ)-activating potencies, we focused our study on telmisartan, an ARB with the highest PPARγ-stimulating activity. METHODS: Human circulating monocytes and monocytic THP-1 (human acute monocytic leukemia cell line) cells were exposed to 50 ng/ml LPS with or without pre-incubation with telmisartan...
January 2012: Journal of Hypertension
https://www.readbyqxmd.com/read/21756814/-lrp16-gene-causes-insulin-resistance-in-c2-c12-cells-by-inhibiting-the-irs-1-signaling-and-the-transcriptional-activity-of-peroxisome-proliferator-actived-receptor-%C3%AE
#18
Li Zang, Yi-ming Mu, Zhao-hui Lü, Bing Xue, Xiao-li Ma, Guo-qing Yang, Jian-ming Ba, Jing-tao Dou, Ju-ming Lu
OBJECTIVE: To explore the effect of LRP (leukemia related protein) 16 on insulin resistance in C2-C12 cells and explore its molecular mechanism. METHODS: Lipidosome transfection and lentivirus mediated siRNA (small interfering RNA) technology were used to establish LRP 16 overexpression and underexpression cell lines and their corresponding control cell lines. And 2-deoxy-[(3)H]-glucose was used to measure the effect of LRP 16 on insulin-stimulated glucose uptake...
May 31, 2011: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/21669866/selenoprotein-dependent-up-regulation-of-hematopoietic-prostaglandin-d2-synthase-in-macrophages-is-mediated-through-the-activation-of-peroxisome-proliferator-activated-receptor-ppar-gamma
#19
Ujjawal H Gandhi, Naveen Kaushal, Kodihalli C Ravindra, Shailaja Hegde, Shakira M Nelson, Vivek Narayan, Hema Vunta, Robert F Paulson, K Sandeep Prabhu
The plasticity of macrophages is evident from their dual role in inflammation and resolution of inflammation that are accompanied by changes in the transcriptome and metabolome. Along these lines, we have previously demonstrated that the micronutrient selenium increases macrophage production of arachidonic acid (AA)-derived anti-inflammatory 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) and decreases the proinflammatory PGE(2). Here, we hypothesized that selenium modulated the metabolism of AA by a differential regulation of various prostaglandin (PG) synthases favoring the production of PGD(2) metabolites, Δ(12)-PGJ(2) and 15d-PGJ(2)...
August 5, 2011: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21620794/carotenoids-inhibit-proliferation-and-regulate-expression-of-peroxisome-proliferators-activated-receptor-gamma-ppar%C3%AE-in-k562-cancer-cells
#20
Xia Zhang, Wen-En Zhao, Liqiang Hu, Lei Zhao, Jinyong Huang
As one of the main micronutrients in vegetables and fruit carotenoids are almost daily intaken in significant quantity. Although the pharmacological roles of carotenoids in the prevention and reduction of cancer incidence have received more and more attention, the exact molecular mechanisms underlying anticancer effects of carotenoids remain unclear yet. Activated peroxisome proliferator-activated receptor gamma (PPARγ) plays an inhibitory role in cancer cell proliferation and growth. Involvement of PPARγ in the growth inhibition of leukemia K562 cells by carotenoids was investigated in the present study...
August 1, 2011: Archives of Biochemistry and Biophysics
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