Cornelius Goerdeler, Beatrice Engelmann, Alix Sarah Aldehoff, Alexandra Schaffert, Matthias Blüher, John T Heiker, Martin Wabitsch, Kristin Schubert, Ulrike Rolle-Kampczyk, Martin von Bergen
Growing evidence suggests that exposure to certain metabolism-disrupting chemicals (MDCs), such as the phthalate plasticizer DEHP, might promote obesity in humans, contributing to the spread of this global health problem. Due to the restriction on the use of phthalates, there has been a shift to safer declared substitutes, including the plasticizer diisononyl-cyclohexane-1,2-dicarboxylate (DINCH). Notwithstanding, recent studies suggest that the primary metabolite monoisononyl-cyclohexane-1,2-dicarboxylic acid ester (MINCH), induces differentiation of human adipocytes and affects enzyme levels of key metabolic pathways...
April 4, 2024: Environmental Research