keyword
MENU ▼
Read by QxMD icon Read
search

Tb prevention

keyword
https://www.readbyqxmd.com/read/28938052/effectiveness-of-tb-sensitization-initiatives-in-improving-the-involvement-of-self-help-group-members-in-rural-tb-control-in-south-india
#1
Beena Thomas, B Priscilla Rebecca, A Dhanalakshmi, S Rani, A Deepa Lakshmi, Basilea Watson, R Vijayalakshmi, M Muniyandi, N Karikalan
Background: The 'End TB strategy' has highlighted the importance of inter-sectoral collaboration and community mobilization for achieving zero TB deaths by 2020. Objective: The aim of the study was to develop and test a model TB sensitization programme involving self help groups (SHGs). Methodology: This experimental study was conducted in two blocks (intervention and control), in Tiruvallur district. The intervention content included short-lecture, musical story telling activity, role play, short film on TB...
December 1, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28937657/synthesis-of-2-4-diaminopyrimidine-core-based-derivatives-and-biological-evaluation-of-their-anti-tubercular-activities
#2
Yifan Ouyang, Hao Yang, Peng Zhang, Yu Wang, Sargit Kaur, Xuanli Zhu, Zhe Wang, Yutong Sun, Wei Hong, Yun Fong Ngeow, Hao Wang
Tuberculosis (TB) is a chronic, potentially fatal disease caused by Mycobacterium tuberculosis (Mtb). The dihyrofolate reductase in Mtb (mt-DHFR) is believed to be an important drug target in anti-TB drug development. This enzyme contains a glycerol (GOL) binding site, which is assumed to be a useful site to improve the selectivity towards human dihyrofolate reductase (h-DHFR). There have been previous attempts to design drugs targeting the GOL binding site, but the designed compounds contain a hydrophilic group, which may prevent the compounds from crossing the cell wall of Mtb to function at the whole cell level...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28932351/abdominal-tuberculosis-is-there-a-role-for-surgery
#3
REVIEW
Elroy Patrick Weledji, Benjamin Thumamo Pokam
It is important that surgeons are familiar with the various manifestations of tuberculosis (TB). Although TB has been declining in incidence in the developed world, it remains an important problem in endemic areas of the developing world. The aim of the review was to elucidate the natural history and characteristics of abdominal TB and ascertain the indications for surgery. TB can affect the intestine as well as the peritoneum and the most important aspect of abdominal TB is to bear in mind the diagnosis and obtain histological evidence...
August 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28930287/exposure-to-human-alveolar-lining-fluid-enhances-mycobacterium-bovis-bcg-vaccine-efficacy-against-mycobacterium-tuberculosis-infection-in-a-cd8-t-cell-dependent-manner
#4
J I Moliva, A P Hossfeld, C H Canan, V Dwivedi, M D Wewers, G Beamer, J Turner, J B Torrelles
Current tuberculosis (TB) treatments include chemotherapy and preventative vaccination with Mycobacterium bovis Bacillus Calmette-Guérin (BCG). In humans, however, BCG vaccination fails to fully protect against pulmonary TB. Few studies have considered the impact of the human lung mucosa (alveolar lining fluid (ALF)), which modifies the Mycobacterium tuberculosis (M.tb) cell wall, revealing alternate antigenic epitopes on the bacterium surface that alter its pathogenicity. We hypothesized that ALF-induced modification of BCG would induce better protection against aerosol infection with M...
September 20, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28915796/correlates-of-isoniazid-preventive-therapy-failure-in-child-household-contacts-with-infectious-tuberculosis-in-high-burden-settings-in-nairobi-kenya-a-cohort-study
#5
Florence Nafula Okwara, John Paul Oyore, Fred Nabwire Were, Samson Gwer
BACKGROUND: Sub-Saharan Africa continues to document high pediatric tuberculosis (TB) burden, especially among the urban poor. One recommended preventive strategy involves tracking and isoniazid preventive therapy (IPT) for children under 5 years in close contact with infectious TB. However, sub-optimal effectiveness has been documented in diverse settings. We conducted a study to elucidate correlates to IPT strategy failure in children below 5 years in high burden settings. METHODS: A prospective longitudinal cohort study was done in informal settlings in Nairobi, where children under 5 years in household contact with recently diagnosed smear positive TB adults were enrolled...
September 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28911357/pulmonary-tuberculosis-diagnostic-practices-among-people-living-with-the-human-immunodeficiency-virus-in-lesotho
#6
D E O'Connor, K Frederix, S Saito, L B Maama, Y Hirsch-Moverman, B Pitt, E Hayes-Larson, L Lebelo, M Shale, A A Howard
SETTING: Twelve health facilities in Berea District, Lesotho, that participated in the Start TB Patients on ART and Retain on Treatment (START) Study, a mixed-methods cluster-randomized trial evaluating a combination intervention package to improve early initiation of antiretroviral therapy (ART) and anti-tuberculosis treatment success among patients with tuberculosis (TB) and human immunodeficiency virus (HIV). OBJECTIVE: To assess TB and HIV diagnostic practices among TB-HIV patients...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911356/high-completion-rates-of-isoniazid-preventive-therapy-among-persons-living-with-hiv-in-swaziland
#7
L V Adams, N Mahlalela, E A Talbot, M Pasipamire, S Ginindza, M Calnan, S Haumba
SETTING: Five human immunodeficiency virus (HIV) care facilities in Swaziland. OBJECTIVE: To assess adherence and treatment completion of a 6-month course of isoniazid preventive therapy (IPT) provided to HIV-infected patients through a self-selected model of facility-based, community-based or peer-supported IPT delivery coordinated with antiretroviral refills. DESIGN: Prospective cohort study. RESULTS: Between February and August 2015, we enrolled 908 patients, with follow-up until February 2016...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911354/drug-resistance-patterns-among-extra-pulmonary-tuberculosis-cases-in-a-tertiary-care-centre-in-north-india
#8
S K Sharma, J Chaubey, B K Singh, R Sharma, A Mittal, A Sharma
BACKGROUND: xtra-pulmonary tuberculosis (EPTB) is a growing public health concern, and data on drug resistance are limited. MATERIAL AND METHODS: Specimens from 2468 clinically diagnosed EPTB patients received at the Intermediate Reference Laboratory (IRL) of a tertiary centre in India were subjected to Ziehl-Neelsen staining, Xpert® MTB/RIF testing, liquid culture and drug susceptibility testing (DST) using automated BACTEC MGIT™ 960™. Line-probe assay (LPA) was performed on all culture-positive isolates...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28910983/quantitative-proteomic-analysis-of-host-responses-triggered-by-mycobacterium-tuberculosis-infection-in-human-macrophage-cells
#9
Hua Li, Sha Wei, Yuan Fang, Min Li, Xia Li, Zhe Li, Jibin Zhang, Guofeng Zhu, Chuanyou Li, Lijun Bi, Guimin Zhang, Dianbing Wang, Xian-En Zhang
Macrophages are primary host of Mycobacterium tuberculosis (M.tb) and the central effector of in vivo innate immune responses against bacteria. Though the interaction between macrophages and mycobacteria has been widely investigated, the molecular mechanisms of M.tb pathogenesis in macrophages are still not clear. In this work, we investigated the altered protein expression profiles of macrophages after virulent H37Rv strain and avirulent H37Ra strain infection by tandem mass tag-based quantitative proteomics...
September 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28910939/-genotyping-and-drug-susceptibility-of-mycobacterium-tuberculosis-isolated-in-changping-district-in-beijing-2011-2015
#10
Z G Zhang, J F Wu, L Wang, L Q Wang, L Han, S B Ma, T J Gao
Objective: To understand the genotype distribution of Mycobacterium tuberculosis and the drug susceptibility of M. tuberculosis with different genotypes in Changping district of Beijing and evaluate the application of genotyping of M. tuberculosis in local tuberculosis (TB) prevention and control. Methods: A total of 1 099 M. tuberculosis strains isolated in Changping from 2011 to 2015 were used. Spoligotyping and 12-locus VNTR recommended by Gao were used for the genotyping of these isolates. In addition, the susceptibility of the M...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910284/caretakers-perspectives-of-paediatric-tb-and-implications-for-care-seeking-behaviours-in-southern-mozambique
#11
Carolina Mindu, Elisa López-Varela, Yara Alonso-Menendez, Yolanda Mausse, Orvalho Joaquim Augusto, Kizito Gondo, Jose Múñoz, Jahit Sacarlal, Alberto L García-Basteiro, Pedro L Alonso, Khátia Munguambe
BACKGROUND: Tuberculosis (TB) remains an important public health concern, especially in poorly resourced settings. TB diagnosis is challenging, particularly for children, who are the most vulnerable to its' impacts. Lack of knowledge and awareness of the disease compromises prompt diagnosis and treatment compliance. OBJECTIVE: To gain insights regarding caretakers' knowledge of the aetiology and prevention of paediatric TB in southern Mozambique, to describe their care-seeking behaviours and to assess the acceptability of diagnostic procedures...
2017: PloS One
https://www.readbyqxmd.com/read/28903800/predicting-treatment-failure-death-and-drug-resistance-using-a-computed-risk-score-among-newly-diagnosed-tb-patients-in-tamaulipas-mexico
#12
B E Abdelbary, M Garcia-Viveros, H Ramirez-Oropesa, M H Rahbar, B I Restrepo
The purpose of this study was to develop a method for identifying newly diagnosed tuberculosis (TB) patients at risk for TB adverse events in Tamaulipas, Mexico. Surveillance data between 2006 and 2013 (8431 subjects) was used to develop risk scores based on predictive modelling. The final models revealed that TB patients failing their treatment regimen were more likely to have at most a primary school education, multi-drug resistance (MDR)-TB, and few to moderate bacilli on acid-fast bacilli smear. TB patients who died were more likely to be older males with MDR-TB, HIV, malnutrition, and reporting excessive alcohol use...
September 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28899805/performance-of-genotype-%C3%A2-mtbdrplus-assay-in-the-diagnosis-of-drug-resistant-tuberculosis-in-tangier-morocco
#13
Hind Karimi, Latifa En-Nanai, Amal Oudghiri, Imane Chaoui, Amin Laglaoui, Jamal Eddine Bourkadi, Mohammed El Mzibri, Mohammed Abid
OBJECTIVES: In Morocco, tuberculosis (TB) is a major public health problem with high morbidity and mortality. The main problem faced by the National TB program is the high rate of drug resistant (DR), particularly multi-drug resistant (MDR) strains. Diagnosis of DR-TB is mainly performed by conventional techniques which are time consuming with limited efficacy. In 2014, GenoType(®) MTBDRplus assay was introduced in Morocco for drug resistance testing. In this regard, the present study was planned to assess the diagnostic accuracy of GenoType(®) MTBDRplus assay...
September 9, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28894715/survival-rates-among-co-infected-patients-with-human-immunodeficiency-virus-tuberculosis-in-tehran-iran
#14
Ghodratollah Roshanaei, Masoud Sabouri Ghannad, Jalal Poorolajal, Minoo Mohraz, Leila Molaeipoor
BACKGROUND: The number of deaths related with co-infection of tuberculosis (TB) and HIV remains inappropriately high worldwide. TB is anticipated to be the major reason of HIV-related deaths globally. This study aimed to find out and evaluate the characteristics of the possible risk factors influencing the survival time of co-infected patients with HIV/TB in Tehran the capital of Iran. METHODS: This retrospective study was performed on the referred patients to the one of two Behavioral Diseases Counseling Centers, Imam Khomeini, and Zamzam Centers, Tehran, Iran, in 2004-2013...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28892445/applying-the-15-public-health-emergency-preparedness-capabilities-to-support-large-scale-tuberculosis-investigations-in-complex-congregate-settings
#15
Alison Jaffe Levy, Katelynne Gardner Toren, Carina Elsenboss, Masahiro Narita
Public Health-Seattle and King County, a metropolitan health department in western Washington, experiences rates of tuberculosis (TB) that are 1.6 times higher than are state and national averages. The department's TB Control Program uses public health emergency management tools and capabilities sustained with Centers for Disease Control and Prevention grant funding to manage large-scale complex case investigations. We have described 3 contact investigations in large congregate settings that the TB Control Program conducted in 2015 and 2016...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28890891/collaborative-approaches-and-policy-opportunities-for-accelerated-progress-toward-effective-disease-prevention-care-and-control-using-the-case-of-poverty-diseases-to-explore-universal-access-to-affordable-health-care
#16
Samia Laokri
BACKGROUND: There is a massive global momentum to progress toward the sustainable development and universal health coverage goals. However, effective policies to health-care coverage can only emerge through high-quality services delivered to empowered care users by means of strong local health systems and a translational standpoint. Health policies aimed at removing user fees for a defined health-care package may fail at reaching desired results if not applied with system thinking. METHOD: Secondary data analysis of two country-based cost-of-illness studies was performed to gain knowledge in informed decision-making toward enhanced access to care in the context of resource-constraint settings...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28886072/stakeholder-perspectives-for-optimization-of-tuberculosis-contact-investigation-in-a-high-burden-setting
#17
Diana Marangu, Hannah Mwaniki, Salome Nduku, Elizabeth Maleche-Obimbo, Walter Jaoko, Joseph Babigumira, Grace John-Stewart, Deepa Rao
INTRODUCTION: Optimal tuberculosis contact investigation impacts TB prevention, timely case finding and linkage to care, however data on routine implementation in high burden contexts is limited. MATERIALS AND METHODS: In a multi-method qualitative study based on individual interviews with TB patients, facility observations and focus group discussions with health workers (HWs) in 13 public health facilities, and key informant interviews with governmental and non-governmental experts, we describe TB contact investigation in the context of an urban setting in Kenya and identify opportunities for optimization...
2017: PloS One
https://www.readbyqxmd.com/read/28885972/use-of-rifapentine-and-isoniazid-directly-observed-therapy-for-the-treatment-of-latent-tuberculosis-infection-in-a-military-clinic
#18
Janelle Jinbo, Michael Lustik, Gordon F West, Megan Kloetzel
BACKGROUND: There are 8.6 million cases of active tuberculosis (TB) worldwide, and an estimated one-third of the world population has latent tuberculosis infection (LTBI). In the United States, up to 80% of active cases may be caused by untreated reactivated latent infection. A case of TB can spread rapidly impacting the readiness of a unit. To prevent the development of TB, it is critical that active duty service members with LTBI complete treatment. The use of isoniazid (INH) and rifapentine (RPT) as a directly observed therapy (DOT) treatment option was recommended by the Centers for Disease Control and Prevention in late 2011...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28881482/altered-expression-of-antigen-specific-memory-and-regulatory-t-cell-subsets-differentiate-latent-and-active-tuberculosis
#19
Balaji Pathakumari, Santhi Devasundaram, Alamelu Raja
Though one-third of the world population is infected with M. tuberculosis, only 5-10% of the infected individuals will develop active TB disease and rest will remain infected with no symptoms known as latent TB infection (LTBI). Identifying biomarkers that differentiate latent and active TB disease enables effective TB control, since early detection, treatment of active TB and preventive treatment of LTBI individuals are crucial steps involved in TB control. Here, we have evaluated the frequency of antigen specific memory and regulatory T cells (Tregs) in 15 healthy household contacts (HHC) and 15 pulmonary TB patients (PTB) to identify biomarkers for differential diagnosis of LTBI and active TB...
September 7, 2017: Immunology
https://www.readbyqxmd.com/read/28879165/developing-a-customised-approach-for-strengthening-tuberculosis-laboratory-quality-management-systems-toward-accreditation
#20
Heidi Albert, Andre Trollip, Donatelle Erni, Kekeletso Kao
BACKGROUND: Quality-assured tuberculosis laboratory services are critical to achieve global and national goals for tuberculosis prevention and care. Implementation of a quality management system (QMS) in laboratories leads to improved quality of diagnostic tests and better patient care. The Strengthening Laboratory Management Toward Accreditation (SLMTA) programme has led to measurable improvements in the QMS of clinical laboratories. However, progress in tuberculosis laboratories has been slower, which may be attributed to the need for a structured tuberculosis-specific approach to implementing QMS...
2017: African Journal of Laboratory Medicine
keyword
keyword
103056
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"