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https://www.readbyqxmd.com/read/28339296/synthetic-parasites-a-successful-mucosal-nanoparticle-vaccine-against-toxoplasma-congenital-infection-in-mice
#1
Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Pierre-Jean Pisella, Hervé Leroux, Nathalie Van Langendonck, Didier Betbeder, Isabelle Dimier-Poisson
AIM: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. MATERIALS & METHODS: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied. RESULTS: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth...
March 24, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28334720/intravitreal-dexamethasone-implant-versus-intravitreal-ranibizumab-for-the-treatment-of-macular-edema-secondary-to-retinal-vein-occlusion-in-a-chinese-population
#2
Xiaoya Gu, Xiaobing Yu, Shuang Song, Hong Dai
BACKGROUND: The aim of this work was to compare the efficacy of intravitreal dexamethasone implant (Ozurdex) and intravitreal ranibizumab (Lucentis) in the treatment of macular edema (ME) caused by retinal vein occlusion (RVO). METHODS: Thirty-two ME cases treated with Ozurdex and 32 ME cases treated with ranibizumab were enrolled, with 26 central (C)RVO and 6 branch (B)RVO subjects in each group. We compared the results of best-corrected visual acuity (BCVA), central retinal thickness, number of injections, and intraocular pressure (IOP) at 1, 2, 3, and 6 months after injection...
March 24, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28333942/comparison-of-self-measured-diurnal-intraocular-pressure-profiles-using-rebound-tonometry-between-primary-angle-closure-glaucoma-and-primary-open-angle-glaucoma-patients
#3
Shaoying Tan, Nafees Baig, Linda Hansapinyo, Vishal Jhanji, Shihui Wei, Clement C Tham
PURPOSE: To document the diurnal intraocular pressure (IOP) profile with rebound tonometry performed by primary glaucoma patients in non-clinic environment. PATIENTS AND METHODS: Fifty-three medically-treated eyes of 31 primary angle closure glaucoma (PACG) and 22 primary open angle glaucoma (POAG) patients with no previous eye surgery were recruited. Diurnal IOP was measured 5 times per day at four-hourly intervals from 08:00 to 24:00 for 1 week in patients' study eye using rebound tonometry in a non-clinic environment...
2017: PloS One
https://www.readbyqxmd.com/read/28333895/visual-field-defects-in-young-patients-with-open-angle-glaucoma-comparison-between-high-tension-and-normal-tension-glaucoma
#4
Ji-Hye Park, Chungkwon Yoo, Jinhwan Park, Yong Yeon Kim
PURPOSE: To investigate the clinical features of young Korean patients with open-angle glaucoma (OAG), and to compare visual field (VF) defects between patients with normal-tension glaucoma (NTG) and those with high-tension glaucoma (HTG). MATERIALS AND METHODS: Patients with OAG younger than 40 years of age were divided into NTG and HTG groups based on untreated intraocular pressure (IOP) level. The patients were matched according to the mean deviation of standard automated perimetry...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333893/magnetic-resonance-imaging-characteristics-of-a-baerveldt-glaucoma-implant
#5
Daniel M Anderson, Ryan B Schwope, Michael J Reiter, Abraham W Suhr
PURPOSE: Evaluate for normative postoperative magnetic resonance imaging (MRI) characteristics of a Baerveldt Glaucoma Implant (BGI). DESIGN: Prospective case series. PARTICIPANTS: Seven subjects with uncontrolled glaucoma requiring a primary superotemporal BGI. METHODS: Subjects prospectively underwent sequential MRI orbital scans without contrast at 0 to 2 weeks, 6 to 8 weeks, and 4 to 6 months after implantation of a BGI model 103-250...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333892/the-effects-of-phacoemulsification-on-intraocular-pressure-and-topical-medication-use-in-patients-with-glaucoma-a-systematic-review-and-meta-analysis-of-3-year-data
#6
James J Armstrong, Tomas Wasiuta, Efstathia Kiatos, Monali Malvankar-Mehta, Cindy M L Hutnik
PURPOSE: For patients with comorbid cataract and primary open-angle glaucoma (POAG), guidance is lacking as to whether cataract extraction and traditional filtering surgery should be performed as a staged or combined procedure. Achieving this guidance requires an evidence-based understanding of the effects of phacoemulsification alone on intraocular pressure (IOP) in patients with POAG. For this reason, a systematic review and meta-analysis was undertaken to synthesize evidence quantifying the effect of phacoemulsification on IOP and the required number of topical glaucoma medications in patients with cataract and POAG...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333891/sd-oct-choroidal-thickness-in-advanced-primary-open-angle-glaucoma
#7
Riccardo Sacconi, Niccolo' Deotto, Tommaso Merz, Roberta Morbio, Stefano Casati, Giorgio Marchini
PURPOSE: To assess the choroidal thickness in advanced primary open-angle glaucoma (POAG) comparing patients affected by advanced glaucoma and normal subject using spectral domain optical coherence tomography (SD-OCT). METHODS: In total, 35 eyes of 35 patients affected by POAG with advanced perimetric defect (mean deviation worse than -12 dB) were prospectively enrolled and underwent a complete ophthalmologic examination, including enhanced depth imaging SD-OCT...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333853/multimodal-imaging-in-vortex-vein-varices
#8
Chiara Veronese, Giovanni Staurenghi, Marco Pellegrini, Chiara Maiolo, Laura Primavera, Mariachiara Morara, Grayson W Armstrong, Antonio P Ciardella
PURPOSE: The aim of this study is to describe the clinical presentation of vortex vein varices with multimodal imaging. METHODS: The authors carried out a retrospective case series of eight patients (7 female, 1 male) with an average age of 60.2 years (min 8, max 84, median 68.5) presenting with vortex vein varices. All patients were evaluated at the Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy and at Luigi Sacco Hospital, University of Milan, Milan, Italy...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333852/re-intervention-in-de-novo-vitreous-opacities-after-pars-plana-vitrectomy-in-familial-amyloidotic-polyneuropathy-ttr-val30metportuguese-patients
#9
Natália Novais Ferreira, David Afonso Cunha Dias, Rui Pedro Afonso Carvalho, Maria Teresa Pardal Monteiro Coelho
PURPOSE: To report management of de novo vitreous amyloid opacities after previous pars plana vitrectomy in familial amyloidotic polyneuropathy transthyretin Val30Met. METHODS: This work is a retrospective observational consecutive case series of five eyes of four patients. Demographic data, transthyretin mutation involved, age at the beginning of disease, duration of disease, treatment (liver transplant or tafamidis), time between vitrectomy and re-intervention, and ophthalmologic changes were evaluated...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333563/effect-of-high-altitude-exposure-on-intraocular-pressure-using-goldmann-applanation-tonometry
#10
Gabriel Willmann, Kai Schommer, Maximilian Schultheiss, M Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, Andreas Schatz
Willmann, Gabriel, Kai Schommer, Maximilian Schultheiss, M. Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, and Andreas Schatz. Effect of high altitude exposure on intraocular pressure using Goldmann applanation tonometry. High Alt Med Biol. 00:000-000, 2017. AIMS: The aim of the study was to quantify changes of intraocular pressure (IOP) during exposure to 4559 m using the state-of-the-art method of Goldmann applanation tonometry for IOP measurement and to detect correlations between IOP and acute mountain sickness (AMS) in a prospective manner...
March 23, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28332616/long-acting-protein-drugs-for-the-treatment-of-ocular-diseases
#11
Joy G Ghosh, Andrew A Nguyen, Chad E Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen, Yiqin Wang, Kulandayan K Subramanian, Elizabeth Fassbender, Michael Maker, Shawn Hanks, Joanna Vrouvlianis, Barrett Leehy, Debby Long, Melissa Prentiss, Viral Kansara, Bruce Jaffee, Thaddeus P Dryja, Michael Roguska
Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently as every month. Here we report a method to extend the intravitreal half-life of protein drugs as an alternative to either encapsulation or chemical modifications with polymers. We combine a 97-amino-acid peptide of human origin that binds hyaluronan, a major macromolecular component of the eye's vitreous, with therapeutic antibodies and proteins...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28332375/quarter-shifted-microincisional-sutureless-vitrectomy-in-patients-with-a-glaucoma-drainage-implant-or-filtering-bleb
#12
Ji Hun Song, Seran Jang, Eun Hyung Cho, Jaehong Ahn
When vitrectomy is performed in eyes that have undergone glaucoma surgery, the site of sclerotomy often overlaps with the previous glaucoma operation site. It can lead to serious complications such as postoperative hypotony, leakage, and/or infection. Our technique involves modification of surgeon's position and two sclerotomy sites 45° away from the original position, with an infusion cannula inserted infranasally to avoid damage to the glaucoma drainage implant or filtering bleb. The modified approach was applied to seven eyes with various indications...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332008/case-of-adult-onset-neuronal-intranuclear-hyaline-inclusion-disease-with-negative-electroretinogram
#13
Wataru Yamada, Akira Takekoshi, Kyoko Ishida, Kiyofumi Mochizuki, Jun Sone, Gen Sobue, Yuichi Hayashi, Takashi Inuzuka, Yozo Miyake
PURPOSE: To report the findings in a 72-year-old man with neuronal intranuclear hyaline inclusion disease (NIHID) with the negative-type electroretinogram (ERG) and without night blindness. METHODS: Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity and intraocular pressures, slit-lamp biomicroscopy, ophthalmoscopy, spectral-domain optical coherence tomography, fundus autofluorescence, and perimetry were performed...
March 22, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28331457/visual-loss-retinal-hemorrhages-and-optic-disc-edema-resulting-from-thiamine-deficiency-following-bariatric-surgery-complicated-by-prolonged-vomiting
#14
Andrew W Lawton, Nicholas E Frisard
BACKGROUND: Vision loss resulting from thiamine deficiency is a recognized complication of bariatric surgery. Most patients with such vision loss have Wernicke encephalopathy with characteristic changes seen on neuroimaging. Other patients may have retinal hemorrhages, optic disc edema, and peripheral neuropathy without Wernicke encephalopathy. The risk for thiamine deficiency is potentiated by the presence of prolonged vomiting. CASE REPORT: A 37-year-old female presented with abrupt onset of vision loss and peripheral neuropathy following bariatric surgery...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28331284/a-retrospective-study-comparing-outcomes-of-primary-rhegmatogenous-retinal-detachment-repair-by-scleral-buckling-and-pars-plana-vitrectomy-in-finland
#15
Sari Sahanne, Raimo Tuuminen, Jari Haukka, Sirpa Loukovaara
BACKGROUND: Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment and an ophthalmic emergency. Here, we compared outcomes of primary RRD eyes operated with conventional scleral buckling (SB) with cryoretinopexy to those operated with standard pars plana vitrectomy (PPV). METHODS: This is an institutional, retrospective, register-based, observational, comparative study. Based on the surgical procedure, 319 eyes of 319 patients were divided into two groups: SB plus cryotherapy (n=50) and PPV (n=269)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28330694/cant1-lncrna-triggers-efficient-therapeutic-efficacy-by-correcting-aberrant-lncing-cascade-in-malignant-uveal-melanoma
#16
Yue Xing, Xuyang Wen, Xia Ding, Jiayan Fan, Peiwei Chai, Renbing Jia, Shengfang Ge, Guanxiang Qian, He Zhang, Xianqun Fan
Uveal melanoma (UM) is an intraocular malignant tumor with a high mortality rate. Recent studies have shown the functions of long non-coding RNAs (lncRNAs) in tumorigenesis; thus, targeting tumor-specific lncRNA abnormalities has become an attractive approach for developing therapeutics to treat uveal melanoma. In this study, we identified a novel nuclear CANT1 lncRNA (CASC15-New-Transcript 1) that acts as a necessary UM suppressor. CANT1 significantly reduced tumor metastatic capacity and tumor formation, either in cell culture or in animals harboring tumor xenograft...
March 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28328997/influence-of-intraocular-lens-subsurface-nanoglistenings-on-functional-visual-acuity
#17
Takahiro Hiraoka, Kazunori Miyata, Takeshi Hayashidera, Masaharu Iida, Keita Takada, Keiichiro Minami, Tetsuro Oshika
To investigate the influence of intraocular lens subsurface nanoglistenings (SSNGs) on functional visual acuity (FVA), thirty-nine eyes of 29 patients were examined in this study. The SSNG group comprised 19 eyes of 14 patients (75.7± 5.4 years, mean ± standard deviation), and the control group comprised 20 eyes of 15 patients (73.6 ± 6.5 years). The SSNGs were diagnosed on the basis of the typical whitish IOL appearance upon slit-lamp examination and results of densitometry regarding surface light scattering using Scheimpflug images...
2017: PloS One
https://www.readbyqxmd.com/read/28328814/clinical-outcomes-of-new-toric-trifocal-diffractive-intraocular-lens-in-patients-with-cataract-and-stable-keratoconus-six-months-follow-up
#18
Doroodgar Farideh, Sanginabadi Azad, Niazi Feizollah, Niazi Sana, Alinia Cyrus, Ghoreishi Mohammad, Baradaran-Rafii Alireza
PURPOSE: To evaluate the clinical results of toric trifocal diffractive intraocular lens in eyes with cataract and mild keratoconus. METHODS: Five keratoconus patients (10 eyes) that had bilateral AT LISA 939 implantation were selected and had followed in 3-time horizons of 1, 3, and 6 months. Patients were 46 to 65 years old age, corneal astigmatism of (2.00 D at 6.75 D) and cataract that all of them needed cataract surgery. The distance, intermediate and near visual acuities, defocus curve, ocular aberrations, contrast sensitivity, were measured as effectiveness criteria...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328621/ocular-involvement-in-children-with-inflammatory-bowel-disease
#19
Samuele Naviglio, Fulvio Parentin, Silvia Nider, Nicolò Rassu, Stefano Martelossi, Alessandro Ventura
BACKGROUND: Data on ocular manifestations of inflammatory bowel disease (IBD) in children are limited. Some authors have reported a high prevalence of asymptomatic uveitis, yet the significance of these observations is unknown and there are no recommendations on which ophthalmologic follow-up should be offered. METHODS: Children with IBD seen at a single referral center for pediatric gastroenterology were offered ophthalmologic evaluation as part of routine care for their disease...
March 21, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28327135/stratification-of-phaco-trabectome-surgery-results-using-a-glaucoma-severity-index-in-a-retrospective-analysis
#20
Pritha Roy, Ralitsa T Loewen, Yalong Dang, Hardik A Parikh, Igor I Bussel, Nils A Loewen
BACKGROUND: To stratify the outcomes of phacoemulsification combined with trabectome surgery using a new glaucoma severity index. METHODS: This is a retrospective, observational cohort study that included open angle glaucoma patients with visually significant cataract that had phacoemulsification combined with trabectome surgery. Exclusion criteria were follow-up less than 12 months, any other surgeries or diagnosis of neovascular or active uveitic glaucoma. Patients were stratified into four groups according to the Glaucoma Index (GI) that incorporated preoperative intraocular pressure (IOP), number of medications and visual field status...
March 21, 2017: BMC Ophthalmology
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