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https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#1
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944413/longer-term-baerveldt-to-trabectome-glaucoma-surgery-comparison-using-propensity-score-matching
#2
Tigran Kostanyan, Tarek Shazly, Kevin B Kaplowitz, Steven Z Wang, Sushma Kola, Eric N Brown, Nils A Loewen
PURPOSE: To apply propensity score matching to compare Baerveldt glaucoma drainage implant (BGI) to Trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggests that AIT can produce results similar to BGI which is traditionally reserved for more severe glaucoma. METHODS: BGI and AIT patients with at least 1 year of follow-up were included. The primary outcome measures were intraocular pressure (IOP), number of glaucoma medications, and a Glaucoma Index (GI) score...
September 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28944211/optic-perineuritis-simultaneously-associated-with-active-pulmonary-tuberculosis-without-intraocular-tuberculosis
#3
Won Yeol Ryu, Jong Soo Kim
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944207/predictive-factors-of-visual-outcome-of-malaysian-cataract-patients-a-retrospective-study
#4
Thanigasalam Thevi, Myron Anthony Godinho
AIM: To explore the associations between various characteristics of Malaysian cataract patients and their management, and their post-operative visual outcomes, to inform relevant bodies to reduce cataract-related blindness. METHODS: We conducted a descriptive secondary data analysis of cataract surgery patients in Melaka Hospital, from 2007 to 2014 using the National Eye Database (NED). Patient-related factors (demographic features, systemic and ocular comorbidities) and management-related factors (surgical duration, type of surgery, type of lens) were analysed for their association with visual outcome (acuity)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944199/comparative-analysis-of-cytomegalovirus-retinitis-and-microvascular-retinopathy-in-patients-with-acquired-immunodeficiency-syndrome
#5
Chao Chen, Chun-Gang Guo, Li Meng, Jing Yu, Lian-Yong Xie, Hong-Wei Dong, Wen-Bin Wei
AIM: To compare the clinical manifestation of cytomegalovirus (CMV) retinitis and microvascular retinopathy (MVR) in patients with acquired immunodeficiency syndrome (AIDS) in China. METHODS: A total of 93 consecutive patients with AIDS, including 41 cases of CMV retinitis and 52 cases of MVR were retrospectively reviewed. Highly active antiretroviral therapy (HAART) status was recorded. HIV and CMV immunoassay were also tested. CD4+ T-lymphocyte count and blood CMV-DNA test were performed in all patients...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944196/long-term-efficacy-and-safety-of-express-implantation-for-treatment-of-open-angle-glaucoma
#6
Geun Young Lee, Chong Eun Lee, Kyoo Won Lee, Sam Seo
AIM: To compare the long-term efficacy and safety of ExPress implantation and standard trabeculectomy in patients with primary open angle glaucoma (POAG). METHODS: In this retrospective study, we compared 17 eyes treated by ExPress implantation with 23 eyes treated by trabeculectomy. Efficacy was assessed according to the relevant intraocular pressure (IOP) values and success rates during the first year of follow-up. Postoperative corneal endothelial cell loss was also compared...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944195/effect-of-phacoemulsification-on-intraocular-pressure-in-patients-with-primary-open-angle-glaucoma-and-pseudoexfoliation-glaucoma
#7
Jesus Jimenez-Roman, Gabriel Lazcano-Gomez, Karina Martínez-Baez, Mauricio Turati, Rosario Gulías-Cañizo, Luis F Hernández-Zimbrón, Lenin Ochoa-De la Paz, Rubén Zamora, Roberto Gonzalez-Salinas
AIM: To compare the effect of phacoemulsification on intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). METHODS: A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in Mexico. The study enrolled consecutive patients having phacoemulsification with intraocular lens (IOL) implantation and a diagnosis of POAG or PXG. Data about IOP values and number of glaucoma medications used was collected at baseline, 1, 3, 6 and 12mo postoperatively...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944192/intraocular-pressure-control-of-a-novel-glaucoma-drainage-device-in-vitro-and-in-vivo-studies
#8
Li-Jun Cui, Di-Chen Li, Jian Liu, Lei Zhang, Yao Xing
AIM: To evaluate the intraocular pressure (IOP) control of an artificial trabeculum drainage system (ATDS), a newly designed glaucoma drainage device, and postoperative complications in normal rabbit eyes. METHODS: Pressure drops in air and fluid of 30 ATDS were measured after being connected to a closed manometric system. Twenty of them were then chosen and implanted randomly into the eyes of 20 rabbits. Postoperative slit-lamp, gonioscopic examination and IOP measurements were recorded periodically...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944155/choroidal-neovascular-membrane-in-intraocular-tuberculosis
#9
Koushik Tripathy
Recently, Lodhi SA and colleagues have reported on a patient with choroidal neovascular membrane (CNVM) associated with tubercular granuloma, who responded to intravitreal bevacizumab injections. The available literature regarding CNVM associated with intraocular tuberculosis is briefly discussed. Choroidal neovascular membrane is a possible complication of choroidal tuberculosis and the patients should be informed about this risk. However, patients usually respond well to intravitreal anti-vascular endothelial growth factor agents as evidenced by the case reported by us and the current case reported by Lodhi et al...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28943916/blockade-of-sonic-hedgehog-signaling-decreases-viability-and-induces-apoptosis-in-retinoblastoma-cells-the-key-role-of-the-pi3k-akt-pathway
#10
Zhidu Song, Yuanyuan Du, Ying Tao
Retinoblastoma (RB) is the most common type of malignant intraocular cancer in teenagers. One of the proteins abnormally expressed during oncogenesis of RB is sonic hedgehog (SHH), which possesses the capability to selectively activate transcription factors of different genes. However, the detailed function of SHH in RB remains unknown. Thus, the present study sought to investigate the role of SHH in the development of RB. The human RB WERI-Rb-1 cell line was used as an in vitro model for the knockdown of SHH by a specific short hairpin RNA (shRNA)...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28942687/effect-of-body-position-on-intraocular-pressure-in-clinically-normal-cats
#11
Masoud Selk Ghaffari, Ahoora Arman Gherekhloo
Objectives The objective of this study was to investigate the effect of body position on intraocular pressure in clinically normal cats. Methods Sixteen clinically normal cats without any ocular abnormalities were used in this study. Cats were sequentially placed in three different recumbency positions (sternal recumbency, right lateral recumbency and dorsal position). For each of the three body positions, intraocular pressure (IOP) was recorded in the left eye using a Tono-Pen Vet tonometer (Reichert). Results Mean IOP readings in cats in the sternal recumbency, right lateral recumbency and dorsal positions were 15...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28942471/an-unusual-complication-of-combined-gonioscopy-assisted-transluminal-trabeculotomy-and-phacoemulsification-vision-loss-due-to-intracapsular-hematoma
#12
Duygu Yalinbas, Zeynep Aktas, İbrahim Hepsen, Nilay Dilekmen
PURPOSE: To report two cases with an acute vision loss due to intracapsular hemorrhage (hematoma) after an uncomplicated gonioscopy-assisted transluminal trabeculotomy (GATT) combined with phacoemulsification surgery. METHODS: Case report. RESULTS: Seventy-six-year-old male and 75-year-old female patients with cataract and pseudoexfoliative glaucoma (XFG) uncontrolled with maximum medical therapy both underwent GATT combined with phacoemulsification...
September 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28942431/uveitis-a-sight-threatening-disease-which-can-impact-all-systems
#13
REVIEW
Unnat Krishna, Deji Ajanaku, Alastair K Denniston, Theodora Gkika
Uveitis describes a group of conditions characterised by intraocular inflammation. The term uveitis technically describes inflammation of the uvea which comprises the iris, ciliary body and choroid, however now encompasses inflammation of adjacent intraocular structures such as the retina, vitreous and optic nerve. Uveitis is a significant cause of blindness worldwide, but its impact is generally underappreciated due to a lack of awareness and understanding of the condition among the public and most non-ophthalmic healthcare professionals...
September 23, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28942074/immunosuppression-for-the-uveitides
#14
REVIEW
Douglas A Jabs
The uveitides are a collection of more than 30 diseases characterized by intraocular inflammation. Many cases of juvenile idiopathic arthritis-associated uveitis, many cases of intermediate uveitis, and most cases of posterior and panuveitides requiring treatment are treated with corticosteroids and immunosuppression. Disease-specific, time-updated modeling of clinical data for several uveitides suggests superior prevention of ocular complications and visual outcomes with immunosuppression. These studies also suggest that oral corticosteroids at doses low enough for safe long-term therapy (i...
September 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28942053/modelling-with-a-meshfree-approach-the-cornea-aqueous-humor-interaction-during-the-air-puff-test
#15
Andrea Montanino, Maurizio Angelillo, Anna Pandolfi
The air puff test is an in-vivo investigative procedure commonly utilized in ophthalmology to estimate the intraocular pressure. Potentially the test, quick and painless, could be combined with inverse analysis methods to characterize the patient-specific mechanical properties of the human cornea. A rapid localized air jet applied on the anterior surface induces the inward motion of the cornea, that interacts with aqueous humor-the fluid filling the narrow space between cornea and iris-with a strong influence on the dynamics of the cornea...
September 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28940022/impairment-of-autoregulation-of-optic-nerve-head-blood-flow-during-vitreous-surgery-in-patients-with-hypertension-and-hyperlipidemia
#16
Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka, Takatoshi Maeno
PURPOSE: To examine whether hypertension (HTN) and hyperlipidemia (HL) affect autoregulation of optic nerve head (ONH) blood flow during vitrectomy. DESIGN: Cohort study. METHODS: Seventeen eyes from 17 subjects with HTN and HL and 19 eyes from 19 control subjects without systemic disorders underwent vitrectomy for the treatment of epiretinal membrane or macular hole. Following standard 25-gauge microincision vitrectomy, the mean blur rate (MBR), which is an index of relative ONH blood flow, in the vascular area (vascular MBR) and MBR in the tissue area (tissue MBR) were measured using laser speckle flowgraphy...
September 23, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28938377/long-term-stability-of-keratometry-scheimpflug-derived-true-net-power-and-total-corneal-refractive-power-after-primary-pterygium-excision
#17
Ka Wai Kam, Timothy A Kuan, Michael W Belin, Alvin L Young
PURPOSE: To evaluate long-term changes in mean keratometry, astigmatism, true net power (TNP), and total corneal refractive power (TCRP) of corneas after primary pterygium excision. METHODS: This is a prospective observational series conducted at a tertiary teaching hospital eye center in Hong Kong. A total of 31 eyes of 31 patients with primary pterygium excision were included. Patients with recurrent or double-headed pterygia or a history of corneal scars from previous trauma, infection, or surgery were excluded...
September 21, 2017: Cornea
https://www.readbyqxmd.com/read/28938016/a-feed-forward-regulation-of-endothelin-receptors-by-c-jun-in-human-non-pigmented-ciliary-epithelial-cells-and-retinal-ganglion-cells
#18
Junming Wang, Hai-Ying Ma, Raghu R Krishnamoorthy, Thomas Yorio, Shaoqing He
c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ) immunohistostaining is associated with upregulation of the ETB receptor within the ganglion cell layer of rats with elevated intraocular pressure (IOP). In addition, both transcription factors regulate the expression of the ETB receptor in human non-pigmented ciliary epithelial cells (HNPE)...
2017: PloS One
https://www.readbyqxmd.com/read/28937876/pilot-study-of-the-pulsatile-neuro-peripapillary-retinal-deformation-in-glaucoma-and-its-relationship-with-glaucoma-risk-factors
#19
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937830/simvastatin-as-an-adjunct-to-conventional-therapy-of-non-infectious-uveitis-a-randomized-open-label-pilot-study
#20
Ivan V Shirinsky, Anastasia A Biryukova, Valery S Shirinsky
PURPOSE: Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvastatin in patients with uveitis. METHODS: For this single-center, open-label, randomized study, we enrolled patients with acute non-infectious uveitis...
September 22, 2017: Current Eye Research
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