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3D printed biomaterial scaffold

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https://www.readbyqxmd.com/read/29054525/development-of-a-tannic-acid-cross-linking-process-for-obtaining-3d-porous-cell-laden-collagen-structure
#1
JiUn Lee, Miji Yeo, WonJin Kim, YoungWon Koo, Geun Hyung Kim
Cell-printing is an emerging technique that enables to build a customized structure using biomaterials and living cells for various biomedical applications. In many biomaterials, alginate has been widely used for rapid gelation, low cost, and relatively high processability. However, biocompatibilities enhancing cell adhesion and proliferation were limited, so that, to overcome this problem, an outstanding alternative, collagen, has been extensively investigated. Many factors remain to be proven for cell-printing applications, such as printability, physical sustainability after printing, and applicability of in vitro cell culture...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29025654/3d-printing-hydrogel-with-graphene-oxide-is-functional-in-cartilage-protection-by-influencing-the-signal-pathway-of-rank-rankl-opg
#2
Zhong Cheng, Bolaky Landish, Zhang Chi, Cui Nannan, Du Jingyu, Lu Sen, Lin Xiangjin
3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of a composite 3D printing scaffold, which in turn is relevant to the protection of cartilage. We transplanted rats with hydrogel/GO-np and hydrogel, which in turn showed that hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29020507/custom-repair-of-mandibular-bone-defects-with-3d-printed-bioceramic-scaffolds
#3
H Shao, M Sun, F Zhang, A Liu, Y He, J Fu, X Yang, H Wang, Z Gou
Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular defects in macro and micro, were manufactured by the 3-dimensional (3D) printing technique according to the computed tomography (CT) image. To evaluate the stimulatory effect of the material substrate on bone tissue regeneration in situ in a rabbit mandibular alveolar bone defect model, implants made with the newly developed, mechanically strong ~10% Mg-substituted wollastonite (Ca90%Mg10%SiO3; CSi-Mg10) were fabricated, implanted into the bone defects, and compared with implants made with the typical Ca-phosphate and Ca-silicate porous bioceramics, such as β-tricalcium phosphate (TCP), wollastonite (CaSiO3; CSi), and bredigite (Bred)...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28976740/3d-printed-pericardium-hydrogels-to-promote-wound-healing-in-vascular-applications
#4
Laura G Bracaglia, Michael Messina, Shira Winston, Che-Ying Kuo, Max Lerman, John P Fisher
Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the native vessel. Evidence is emerging that incorporating predetermined building-blocks into a tissue engineering scaffold may oversimplify the environment and ignore critical structures and binding sites essential to development at the implant...
October 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28976366/recombinant-spider-silk-based-bioinks
#5
Elise DeSimone, Kristin Schacht, Alexandra Pellert, Thomas Scheibel
Bioinks, 3D cell culture systems which can be printed, are still in the early development stages. Currently, extensive research is going into designing printers to be more accommodating to bioinks, designing scaffolds with stiff materials as support structures for the often soft bioinks, and modifying the bioinks themselves. Recombinant spider silk proteins, a potential biomaterial component for bioinks, have high biocompatibility, can be processed into several morphologies and can be modified with cell adhesion motifs to enhance their bioactivity...
October 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28966095/3d-printing-of-hybrid-biomaterials-for-bone-tissue-engineering-calcium-polyphosphate-microparticles-encapsulated-by-polycaprolactone
#6
Meik Neufurth, Xiaohong Wang, Shunfeng Wang, Renate Steffen, Maximilian Ackermann, Natalie D Haep, Heinz C Schröder, Werner E G Müller
Here we describe the formulation of a morphogenetically active bio-ink consisting of amorphous microparticles (MP) prepared from Ca(2+) and the physiological inorganic polymer, polyphosphate (polyP). Those MP had been fortified by mixing with poly-ε-caprolactone (PCL) to allow 3D-bioprinting. The resulting granular PCL/Ca-polyP-MP hybrid material, liquefied by short-time heating to 100°C, was used for the 3D-printing of tissue-like scaffolds formed by strands with a thickness of 400 µm and a stacked architecture leaving ≈0...
September 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28917939/preparation-and-characterization-of-gelatin-%C3%AE-tcp-sf-biocomposite-scaffold-for-bone-tissue-regeneration
#7
JunTae Huh, JiUn Lee, WonJin Kim, Miji Yeo, GeunHyung Kim
In this study, we suggest a new biocomposite scaffold composed of gelatin/α-TCP (tricalcium phosphate)/SF (silk-fibroin) (GTS) which has enhanced mechanical strength and high level of cellular activity. To fabricate GTS scaffold, a temperature-controlled 3D printing process was used and appropriate printing conditions were selected based on rheological data. To show the feasibility as a biomedical scaffold for bone tissue regeneration, the various physical and biological results, using MG63 (osteoblast-like cells), of the GTS scaffold were compared with those of a pure gelatin (G) and gelatin/α-TCP (GT) composite scaffold...
September 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28888018/preparation-and-characterization-of-photocured-poly-%C3%AE%C2%B5-caprolactone-diacrylate-poly-ethylene-glycol-diacrylate-chitosan-for-photopolymerization-type-3d-printing-tissue-engineering-scaffold-application
#8
Yih-Lin Cheng, Freeman Chen
Because of its biocompatible, biodegradable and antimicrobial properties, chitosan is an attractive biomaterial for use in tissue engineering scaffolds. This work builds on previous research by incorporating 95% DD chitosan into a visible-light curable resin which is compatible with a digital light processing (DLP™) projection additive manufacturing (3D printing) system. Different concentrations of chitosan were added to a poly (ε-caprolactone)-diacrylate/poly (ethylene glycol)-diacrylate baseline resin and the samples were extensively characterized...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28776691/three-dimensionally-printed-polyetherketoneketone-scaffolds-with-mesenchymal-stem-cells-for-the-reconstruction-of-critical-sized-mandibular-defects
#9
Michael G Roskies, Dongdong Fang, Mohamed-Nur Abdallah, Andre M Charbonneau, Navi Cohen, Jack O Jordan, Michael P Hier, Alex Mlynarek, Faleh Tamimi, Simon D Tran
OBJECTIVE: Additive manufacturing offers a tailored approach to tissue engineering by providing anatomically precise scaffolds onto which stem cells and growth factors can be supplied. Polyetherketoneketone (PEKK), an ideal candidate biomaterial, is limited by a poor implant-bone interface but can be functionalized with adipose-derived stem cells (ADSC) to promote integration. This in vivo study examined the interaction of a three-dimensional printed PEKK/ADSC implant within the critical-sized mandibular defect in a rabbit model...
August 4, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28772411/additively-manufactured-scaffolds-for-bone-tissue-engineering-and-the-prediction-of-their-mechanical-behavior-a-review
#10
REVIEW
Xiang-Yu Zhang, Gang Fang, Jie Zhou
Additive manufacturing (AM), nowadays commonly known as 3D printing, is a revolutionary materials processing technology, particularly suitable for the production of low-volume parts with high shape complexities and often with multiple functions. As such, it holds great promise for the fabrication of patient-specific implants. In recent years, remarkable progress has been made in implementing AM in the bio-fabrication field. This paper presents an overview on the state-of-the-art AM technology for bone tissue engineering (BTE) scaffolds, with a particular focus on the AM scaffolds made of metallic biomaterials...
January 10, 2017: Materials
https://www.readbyqxmd.com/read/28759433/engineering-derived-approaches-for-ipsc-preparation-expansion-differentiation-and-applications
#11
Yang Li, Ling Li, Zhi-Nan Chen, Ge Gao, Rui Yao, Wei Sun
Remarkable achievements have been made since induced pluripotent stem cells (iPSCs) were first introduced in 2006. Compared with non-pluripotent stem cells, iPSC research faces several additional complexities, such as the choice of extracellular matrix proteins, growth and differentiation factors, as well as technical challenges related to self-renewal and directed differentiation. Overcoming these challenges requires the integration of knowledge and technologies from multiple fields including cell biology, biomaterial science, engineering, physics and medicine...
July 31, 2017: Biofabrication
https://www.readbyqxmd.com/read/28754244/3d-printed-biomaterials-with-regional-auxetic-properties
#12
John J Warner, Allison R Gillies, Henry H Hwang, Hong Zhang, Richard L Lieber, Shaochen Chen
Tissue engineering is replete with methods for inducing and mediating cell differentiation, which are crucial for ensuring proper regrowth of desired tissues. In this study, we developed a 3D-printed, non-positive Poisson's Ratio (NPPR) scaffold intended for future use in stretch-mediated cell differentiation applications, such as in muscle and tendon regeneration. We utilized dynamic optical projection stereolithography (DOPsL) to fabricate multi-layered, cell-laden NPPR scaffolds - these scaffolds can not only support aggregate cell growth, but can also be printed with locally-tunable force-displacement properties at length scales appropriate for tissue interaction...
May 19, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28718059/recent-advances-in-tissue-engineering-strategies-for-the-treatment-of-joint-damage
#13
REVIEW
Makeda K Stephenson, Ashley L Farris, Warren L Grayson
PURPOSE OF REVIEW: While the clinical potential of tissue engineering for treating joint damage has yet to be realized, research and commercialization efforts in the field are geared towards overcoming major obstacles to clinical translation, as well as towards achieving engineered grafts that recapitulate the unique structures, function, and physiology of the joint. In this review, we describe recent advances in technologies aimed at obtaining biomaterials, stem cells, and bioreactors that will enable the development of effective tissue-engineered treatments for repairing joint damage...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28675678/3d-bioprinting-and-the-current-applications-in-tissue-engineering
#14
REVIEW
Ying Huang, Xiao-Fei Zhang, Guifang Gao, Tomo Yonezawa, Xiaofeng Cui
Bioprinting as an enabling technology for tissue engineering possesses the promises to fabricate highly mimicked tissue or organs with digital control. As one of the biofabrication approaches, bioprinting has the advantages of high throughput and precise control of both scaffold and cells. Therefore, this technology is not only ideal for translational medicine but also for basic research applications. Bioprinting has already been widely applied to construct functional tissues such as vasculature, muscle, cartilage, and bone...
July 4, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28639959/3d-printing-current-use-in-facial-plastic-and-reconstructive-surgery
#15
Tsung-Yen Hsieh, Raj Dedhia, Brian Cervenka, Travis T Tollefson
PURPOSE OF REVIEW: To review the use of three-dimensional (3D) printing in facial plastic and reconstructive surgery, with a focus on current uses in surgical training, surgical planning, clinical outcomes, and biomedical research. To evaluate the limitations and future implications of 3D printing in facial plastic and reconstructive surgery. RECENT FINDINGS: Studies reviewed demonstrated 3D printing applications in surgical planning including accurate anatomic biomodels, surgical cutting guides in reconstruction, and patient-specific implants fabrication...
August 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28634956/microfluidic-bioprinting-of-heterogeneous-3d-tissue-constructs
#16
Cristina Colosi, Marco Costantini, Andrea Barbetta, Mariella Dentini
3D bioprinting is an emerging field that can be described as a robotic additive biofabrication technology that has the potential to build tissues or organs. In general, bioprinting uses a computer-controlled printing device to accurately deposit cells and biomaterials into precise architectures with the goal of creating on demand organized multicellular tissue structures and eventually intra-organ vascular networks. The latter, in turn, will promote the host integration of the engineered tissue/organ in situ once implanted...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28631614/3d-printed-bioceramic-scaffolds-with-antibacterial-and-osteogenic-activity
#17
Yongliang Zhang, Dong Zhai, Mengchi Xu, Qingqiang Yao, Huiying Zhu, Jiang Chang, Chengtie Wu
Bacterial infection poses a significant risk with the wide application of bone graft materials. Designing bone grafts with good antibacterial performance and excellent bone-forming activity is of particular significance for bone tissue engineering. In our study, a 3D printing method was used to prepare β-tricalcium phosphate (β-TCP) bioceramic scaffolds. Silver (Ag) nanoparticles were uniformly dispersed on graphene oxide (GO) to form a homogeneous nanocomposite (named Ag@GO) with different Ag-to-graphene oxide mass ratios, with this being synthesized via the liquid chemical reduction approach...
June 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28585319/structurally-and-functionally-optimized-silk-fibroin-gelatin-scaffold-using-3d-printing-to-repair-cartilage-injury-in-vitro-and-in-vivo
#18
Weili Shi, Muyang Sun, Xiaoqing Hu, Bo Ren, Jin Cheng, Chenxi Li, Xiaoning Duan, Xin Fu, Jiying Zhang, Haifeng Chen, Yingfang Ao
Articular cartilage repair remains a great challenge for clinicians and researchers. Recently, there emerges a promising way to achieve one-step cartilage repair in situ by combining endogenic bone marrow stem cells (BMSCs) with suitable biomaterials using a tissue engineering technique. To meet the increasing demand for cartilage tissue engineering, a structurally and functionally optimized scaffold is designed, by integrating silk fibroin with gelatin in combination with BMSC-specific-affinity peptide using 3D printing (3DP) technology...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28576050/extraction-and-characterization-of-collagen-from-antarctic-and-sub-antarctic-squid-and-its-potential-application-in-hybrid-scaffolds-for-tissue-engineering
#19
Rui C G Coelho, Ana L P Marques, Sara M Oliveira, Gabriela S Diogo, Rogério P Pirraco, Joana Moreira-Silva, José C Xavier, Rui L Reis, Tiago H Silva, João F Mano
Collagen is the most abundant protein found in mammals and it exhibits a low immunogenicity, high biocompatibility and biodegradability when compared with others natural polymers. For this reason, it has been explored for the development of biologically instructive biomaterials with applications for tissue substitution and regeneration. Marine origin collagen has been pursued as an alternative to the more common bovine and porcine origins. This study focused on squid (Teuthoidea: Cephalopoda), particularly the Antarctic squid Kondakovia longimana and the Sub-Antarctic squid Illex argentinus as potential collagen sources...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28558161/-printability-of-candidate-biomaterials-for-extrusion-based-3d-printing-state-of-the-art
#20
REVIEW
Stuart Kyle, Zita M Jessop, Ayesha Al-Sabah, Iain S Whitaker
Regenerative medicine has been highlighted as one of the UK's 8 'Great Technologies' with the potential to revolutionize patient care in the 21st Century. Over the last decade, the concept of '3D bioprinting' has emerged, which allows the precise deposition of cell laden bioinks with the aim of engineering complex, functional tissues. For 3D printing to be used clinically, there is the need to produce advanced functional biomaterials, a new generation of bioinks with suitable cell culture and high shape/print fidelity, to match or exceed the physical, chemical and biological properties of human tissue...
August 2017: Advanced Healthcare Materials
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