keyword
MENU ▼
Read by QxMD icon Read
search

3D printed biomaterial scaffold

keyword
https://www.readbyqxmd.com/read/29656075/3d-printed-scaffolds-with-bioactive-elements-induced-photothermal-effect-for-bone-tumor-therapy
#1
Yaqin Liu, Tao Li, Hongshi Ma, Dong Zhai, Cuijun Deng, Jinwu Wang, Shangjun Zhuo, Jiang Chang, Chengtie Wu
For treatment of bone tumor and regeneration of bone defects, the biomaterials should possess the ability to kill tumor cells and regenerate bone defect simultaneously. To date, there are a few biomaterials possessing such dual functions, the disadvantages, however, such as long-term toxicity and degradation, restrict their application. Although bioactive elements have been incorporated into biomaterials to improve their osteogenic activity, there is no report about elements-induced functional scaffolds for photothermal tumor therapy...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29643002/3d-printing-of-a-lithium-calcium-silicate-crystal-bioscaffold-with-dual-bioactivities-for-osteochondral-interface-reconstruction
#2
Lei Chen, Cuijun Deng, Jiayi Li, Qingqiang Yao, Jiang Chang, Liming Wang, Chengtie Wu
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2 Ca4 Si4 O13 , L2 C4 S4 ) bioceramic by a sol-gel method, and further prepared L2 C4 S4 scaffolds by using a 3D-printing method...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29608960/update-on-the-main-use-of-biomaterials-and-techniques-associated-with-tissue-engineering
#3
REVIEW
Daniela Steffens, Daikelly I Braghirolli, Natasha Maurmann, Patricia Pranke
Regenerative medicine involves the study of cells, signaling cues and biomatrices to restore normal function of tissues and organs. To develop the matrices for use in tissue engineering there are three main groups of biomaterials: (i) naturally derived materials; (ii) synthetic polymers; and (iii) decellularized organ or tissue scaffolds. These biomaterials, in various forms such as hydrogels, nanofibers and 3D scaffolds, among others, have been employed for different tissue regeneration purposes, with several techniques involved in their production, including rapid prototyping, tissue decellularization and electrospinning...
March 30, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29570458/3d-printing-strategies-for-peripheral-nerve-regeneration
#4
Eugen B Petcu, Rajiv Midha, Erin McColl, Aurel Popa-Wagner, Traian V Chirila, Paul D Dalton
After many decades of biomaterials research for peripheral nerve regeneration, a clinical product (the nerve guide), is emerging as a proven alternative for relatively short injury gaps. This review identifies aspects where 3D printing can assist in improving long-distance nerve guide regeneration strategies. These include (1) 3D printing of the customizable nerve guides, (2) fabrication of scaffolds that fill nerve guides, (3) 3D bioprinting of cells within a matrix/bioink into the nerve guide lumen and the (4) establishment of growth factor gradients along the length a nerve guide...
March 23, 2018: Biofabrication
https://www.readbyqxmd.com/read/29563069/biological-evaluation-and-finite-element-modeling-of-porous-poly-para-phenylene-for-orthopaedic-implants
#5
Hyunhee Ahn, Ravi R Patel, Anthony J Hoyt, Angela S P Lin, F Brennan Torstrick, Robert E Guldberg, Carl P Frick, R Dana Carpenter, Christopher M Yakacki, Nick J Willett
Poly(para-phenylene) (PPP) is a novel aromatic polymer with higher strength and stiffness than polyetheretherketone (PEEK), the gold standard material for polymeric load-bearing orthopaedic implants. The amorphous structure of PPP makes it relatively straightforward to manufacture different architectures, while maintaining mechanical properties. PPP is promising as a potential orthopaedic material; however, the biocompatibility and osseointegration have not been well investigated. The objective of this study was to evaluate biological and mechanical behavior of PPP, with or without porosity, in comparison to PEEK...
March 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29558424/3d-printability-of-alginate-carboxymethyl-cellulose-hydrogel
#6
Ahasan Habib, Venkatachalem Sathish, Sanku Mallik, Bashir Khoda
Three-dimensional (3D) bio-printing is a revolutionary technology to reproduce a 3D functional living tissue scaffold in-vitro through controlled layer-by-layer deposition of biomaterials along with high precision positioning of cells. Due to its bio-compatibility, natural hydrogels are commonly considered as the scaffold material. However, the mechanical integrity of a hydrogel material, especially in 3D scaffold architecture, is an issue. In this research, a novel hybrid hydrogel, that is, sodium alginate with carboxymethyl cellulose (CMC) is developed and systematic quantitative characterization tests are conducted to validate its printability, shape fidelity and cell viability...
March 20, 2018: Materials
https://www.readbyqxmd.com/read/29520670/3d-powder-printed-tetracalcium-phosphate-scaffold-with-phytic-acid-binder-fabrication-microstructure-and-in-situ-x-ray-tomography-analysis-of-compressive-failure
#7
Sourav Mandal, Susanne Meininger, Uwe Gbureck, Bikramjit Basu
One of the important aspects in 3D powder printing (3DPP) is the selection of binder for a specific material composition to produce scaffolds with desired microstructure and physico-chemical properties. To this end, a new powder-binder combination, namely tetracalcium phosphate (TTCP) and phytic acid (IP6) was investigated at ambient temperature, for low load bearing application. A minimal deviation (<200 µm, w.r.t. computer aided design) was observed in the final sample through optimization of 3DPP process, along with minimum strut and macro-pore size of 200 and 750 µm, respectively...
March 8, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29519423/fabrication-of-micro-nanoporous-collagen-decm-silk-fibroin-biocomposite-scaffolds-using-a-low-temperature-3d-printing-process-for-bone-tissue-regeneration
#8
Hyeongjin Lee, Gi Hoon Yang, Minseong Kim, JaeYoon Lee, JunTae Huh, GeunHyung Kim
Biomaterials must be biocompatible, biodegradable, and mechanically stable to be used for tissue engineering applications. Among various biomaterials, a natural-based biopolymer, collagen, has been widely applied in tissue engineering because of its outstanding biocompatibility. However, due to its low mechanical properties, collagen has been a challenge to build a desired/complex 3D porous structure with appropriate mechanical strength. To overcome this problem, in this study, we used a low temperature printing process to create a 3D porous scaffold consisting of collagen, decellularized extracellular matrix (dECM) to induce high cellular activities, and silk-fibroin (SF) to attain the proper mechanical strength...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29494503/recent-advances-in-biomaterials-for-3d-printing-and-tissue-engineering
#9
REVIEW
Udayabhanu Jammalamadaka, Karthik Tappa
Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D printing in the field of regenerative medicine and tissue engineering are limited by the variety of biomaterials that can be used in this technology. Many researchers have developed novel biomaterials and compositions to enable their use in 3D printing methods. The advantages of fabricating scaffolds using 3D printing are numerous, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors...
March 1, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#10
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29414913/novel-biomaterials-used-in-medical-3d-printing-techniques
#11
REVIEW
Karthik Tappa, Udayabhanu Jammalamadaka
The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and pharmaceutical fields. A vast variety of biomaterials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. With continuous research and progress in biomaterials used in 3D printing, there has been a rapid growth in applications of 3D printing in manufacturing customized implants, prostheses, drug delivery devices, and 3D scaffolds for tissue engineering and regenerative medicine...
February 7, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29407343/a-bifunctional-scaffold-with-cufese2-nanocrystals-for-tumor-therapy-and-bone-reconstruction
#12
Wentao Dang, Tao Li, Bo Li, Hongshi Ma, Dong Zhai, Xiaocheng Wang, Jiang Chang, Yin Xiao, Jinwu Wang, Chengtie Wu
Bone tumor is one of major challenging issues clinically. After surgical intervention, a few bone tumor cells still remain around bone defects and then proliferate over days. Fabrication of specific biomaterials with dual functions of bone tumor therapy and bone regeneration is of great significance. In order to achieve this aim, we managed to prepare bioactive glass (BG) scaffolds functionalized by the CuFeSe2 nanocrystals (BG-CFS) by combining 3D printing technique with solvothermal method. During the solvothermal reaction process, CuFeSe2 nanocrystals could in situ grow on the strut surface of BG scaffolds and thus endow BG scaffolds excellent photothermal performance...
January 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29317370/3d-printed-gelatin-scaffolds-of-differing-pore-geometry-modulate-hepatocyte-function-and-gene-expression
#13
Phillip L Lewis, Richard M Green, Ramille N Shah
Three dimensional (3D) printing is highly amenable to the fabrication of tissue-engineered organs of a repetitive microstructure such as the liver. The creation of uniform and geometrically repetitive tissue scaffolds can also allow for the control over cellular aggregation and nutrient diffusion. However, the effect of differing geometries, while controlling for pore size, has yet to be investigated in the context of hepatocyte function. In this study, we show the ability to precisely control pore geometry of 3D-printed gelatin scaffolds...
March 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29282550/bioactive-calcium-silicate-poly-%C3%AE%C2%B5-caprolactone-composite-scaffolds-3d-printed-under-mild-conditions-for-bone-tissue-engineering
#14
Yen-Hong Lin, Yung-Cheng Chiu, Yu-Fang Shen, Yuan-Haw Andrew Wu, Ming-You Shie
The present study provides a solvent-free processing method for establishing the ideal porous 3-dimension (3D) scaffold filled with different ratios of calcium silicate-based (CS) powder and polycaprolactone (PCL) for 3D bone substitute application. Characterization of hybrid scaffolds developed underwent assessments for physicochemical properties and biodegradation. Adhesion and growth of human Wharton's Jelly mesenchymal stem cells (WJMSCs) on the CS/PCL blended scaffold were investigated in vitro. Cell attachment and morphology were examined by scanning electron microscope (SEM) and confocal microscope observations...
December 27, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29280325/design-and-structure-function-characterization-of-3d-printed-synthetic-porous-biomaterials-for-tissue-engineering
#15
REVIEW
Cambre N Kelly, Andrew T Miller, Scott J Hollister, Robert E Guldberg, Ken Gall
3D printing is now adopted for use in a variety of industries and functions. In biomedical engineering, 3D printing has prevailed over more traditional manufacturing methods in tissue engineering due to its high degree of control over both macro- and microarchitecture of porous tissue scaffolds. However, with the improved flexibility in design come new challenges in characterizing the structure-function relationships between various architectures and both mechanical and biological properties in an assortment of clinical applications...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29199637/automated-3d-bioassembly-of-micro-tissues-for-biofabrication-of-hybrid-tissue-engineered-constructs
#16
N V Mekhileri, K S Lim, G C J Brown, I Mutreja, B S Schon, G J Hooper, T B F Woodfield
Bottom-up biofabrication approaches combining micro-tissue fabrication techniques with extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in tissue engineering. These biofabrication strategies support native self-assembly mechanisms observed in developmental stages of tissue or organoid growth as well as promoting cell-cell interactions and cell differentiation capacity. Few technologies have been developed to automate the precise assembly of micro-tissues or tissue modules into structural scaffolds...
January 12, 2018: Biofabrication
https://www.readbyqxmd.com/read/29197301/dispensing-based-bioprinting-of-mechanically-functional-hybrid-scaffolds-with-vessel-like-channels-for-tissue-engineering-applications-a-brief-review
#17
REVIEW
Saman Naghieh, Md Sarker, Mohammad Izadifar, Xiongbiao Chen
Over the past decades, significant progress has been achieved in the field of tissue engineering (TE) to restore/repair damaged tissues or organs and, in this regard, scaffolds made from biomaterials have played a critical role. Notably, recent advances in biomaterials and three-dimensional (3D) printing have enabled the manipulation of two or more biomaterials of distinct, yet complementary, mechanical and/or biological properties to form so-called hybrid scaffolds mimicking native tissues. Among various biomaterials, hydrogels synthesized to incorporate living cells and/or biological molecules have dominated due to their hydrated tissue-like environment...
February 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29171867/enthusiastic-portrayal-of-3d-bioprinting-in-the-media-ethical-side-effects
#18
Frederic Gilbert, John Noel M Viaña, Cathal D O'Connell, Susan Dodds
There has been a surge in mass media reports extolling the potential for using three-dimensional printing of biomaterials (3D bioprinting) to treat a wide range of clinical conditions. Given that mass media is recognized as one of the most important sources of health and medical information for the general public, especially prospective patients, we report and discuss the ethical consequences of coverage of 3D bioprinting in the media. First, we illustrate how positive mass media narratives of a similar biofabricated technology, namely the Macchiarini scaffold tracheas, which was involved in lethal experimental human trials, influenced potential patient perceptions...
February 2018: Bioethics
https://www.readbyqxmd.com/read/29129026/micromechanical-study-of-the-load-transfer-in-a-polycaprolactone-collagen-hybrid-scaffold-when-subjected-to-unconfined-and-confined-compression
#19
A P G Castro, D Lacroix
Scaffolds are used in diverse tissue engineering applications as hosts for cell proliferation and extracellular matrix formation. One of the most used tissue engineering materials is collagen, which is well known to be a natural biomaterial, also frequently used as cell substrate, given its natural abundance and intrinsic biocompatibility. This study aims to evaluate how the macroscopic biomechanical stimuli applied on a construct made of polycaprolactone scaffold embedded in a collagen substrate translate into microscopic stimuli at the cell level...
November 11, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29128598/histological-and-radiological-evaluation-of-subcutaneous-implants-in-mouse-of-a-3d-printable-material-fulcure-720-and-experimental-application-in-mandibular-reconstruction
#20
J Megías Barrera, L García-Consuegra, A Novoa, S Costilla, S Junquera, G Ascani
INTRODUCTION: The aim of this study was to evaluate the bioactivity of Fullcure compared to porous polyethylene implants (Medpor) in rats prior to custom-made scaffold support manufacturing for mandible segmental defects (MSD) reconstruction in sheep. METHODS: Twelve Fullcure and Medpor laminaes were implanted in the left and right dorsum respectively of six wistar rats. Toxicity was assessed by skin, kidney and liver histopathology three months post-implantation...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
keyword
keyword
103053
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"