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3D printed biomaterial scaffold

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https://www.readbyqxmd.com/read/29900676/feasibility-and-biocompatibility-of-3d-printed-photopolymerized-and-laser-sintered-polymers-for-neuronal-myogenic-and-hepatic-cell-types
#1
Rowan P Rimington, Andrew J Capel, Darren J Player, Richard J Bibb, Steven D R Christie, Mark P Lewis
The integration of additive manufacturing (AM) technology within biological systems holds significant potential, specifically when refining the methods utilized for the creation of in vitro models. Therefore, examination of cellular interaction with the physical/physicochemical properties of 3D-printed polymers is critically important. In this work, skeletal muscle (C2 C12 ), neuronal (SH-SY5Y) and hepatic (HepG2) cell lines are utilized to ascertain critical evidence of cellular behavior in response to 3D-printed candidate polymers: Clear-FL (stereolithography, SL), PA-12 (laser sintering, LS), and VeroClear (PolyJet)...
June 13, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29848794/tailoring-nanostructure-and-bioactivity-of-3d-printable-hydrogels-with-self-assemble-peptides-amphiphile-pa-for-promoting-bile-duct-formation
#2
Ming Yan, Phillip L Lewis, Ramille N Shah
3D-printing has expanded our ability to produce reproducible and more complex scaffold architectures for tissue engineering applications. In order to enhance the biological response within these 3D printed scaffolds incorporating nanostructural features and/or specific biological signaling may be an effective means to optimize tissue regeneration. Peptides Amphiphiles (PAs) are a versatile supramolecular biomaterial with tailorable nanostructural and biochemical features. PAs are widely used in tissue engineering applications such as angiogenesis, neurogenesis, and bone regeneration...
May 31, 2018: Biofabrication
https://www.readbyqxmd.com/read/29754201/skin-bioprinting-a-novel-approach-for-creating-artificial-skin-from-synthetic-and-natural-building-blocks
#3
Robin Augustine
Significant progress has been made over the past few decades in the development of in vitro-engineered substitutes that mimic human skin, either as grafts for the replacement of lost skin, or for the establishment of in vitro human skin models. Tissue engineering has been developing as a novel strategy by employing the recent advances in various fields such as polymer engineering, bioengineering, stem cell research and nanomedicine. Recently, an advancement of 3D printing technology referred as bioprinting was exploited to make cell loaded scaffolds to produce constructs which are more matching with the native tissue...
May 12, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29744452/3d-bioprinting-for-biomedical-devices-and-tissue-engineering-a-review-of-recent-trends-and-advances
#4
REVIEW
Soroosh Derakhshanfar, Rene Mbeleck, Kaige Xu, Xingying Zhang, Wen Zhong, Malcolm Xing
3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting...
June 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29692270/recent-advances-in-endocrine-metabolic-and-immune-disorders-mesenchymal-stem-cells-mscs-and-engineered-scaffolds
#5
Stefania Cantore, Vito Crincoli, Antonio Boccaccio, Antonio Emmanuele Uva, Michele Fiorentino, Giuseppe Monno, Patrizio Bollero, Chiara Derla, Francesca Fabiano, Andrea Ballini, Luigi Santacroce
BACKGROUND: New sources of stem cells in adult organisms are constantly emerging. Postnatal Mesenchymal Stem Cells (MSCs), are the most promising support to perform an effective regenerative medicine: such cells have the ability to differentiate into several lineages, such as osteoblasts and chondroblasts, providing novel strategies to improve different complex treatments, during bone regeneration. 3D-printed biomaterials can be designed with geometry aimed to induce stem cells to differentiate towards specific lineage...
April 22, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29691816/synthetic-materials-for-osteochondral-tissue-engineering
#6
Antoniac Iulian, Laptoiu Dan, Tecu Camelia, Milea Claudia, Gradinaru Sebastian
The objective of an articular cartilage repair treatment is to repair the affected surface of an articular joint's hyaline cartilage. Currently, both biological and tissue engineering research is concerned with discovering the clues needed to stimulate cells to regenerate tissues and organs totally or partially. The latest findings on nanotechnology advances along with the processability of synthetic biomaterials have succeeded in creating a new range of materials to develop into the desired biological responses to the cellular level...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29656075/3d-printed-scaffolds-with-bioactive-elements-induced-photothermal-effect-for-bone-tumor-therapy
#7
Yaqin Liu, Tao Li, Hongshi Ma, Dong Zhai, Cuijun Deng, Jinwu Wang, Shangjun Zhuo, Jiang Chang, Chengtie Wu
For treatment of bone tumor and regeneration of bone defects, the biomaterials should possess the ability to kill tumor cells and regenerate bone defect simultaneously. To date, there are a few biomaterials possessing such dual functions, the disadvantages, however, such as long-term toxicity and degradation, restrict their application. Although bioactive elements have been incorporated into biomaterials to improve their osteogenic activity, there is no report about elements-induced functional scaffolds for photothermal tumor therapy...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29643002/3d-printing-of-a-lithium-calcium-silicate-crystal-bioscaffold-with-dual-bioactivities-for-osteochondral-interface-reconstruction
#8
Lei Chen, Cuijun Deng, Jiayi Li, Qingqiang Yao, Jiang Chang, Liming Wang, Chengtie Wu
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2 Ca4 Si4 O13 , L2 C4 S4 ) bioceramic by a sol-gel method, and further prepared L2 C4 S4 scaffolds by using a 3D-printing method...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29608960/update-on-the-main-use-of-biomaterials-and-techniques-associated-with-tissue-engineering
#9
REVIEW
Daniela Steffens, Daikelly I Braghirolli, Natasha Maurmann, Patricia Pranke
Regenerative medicine involves the study of cells, signaling cues and biomatrices to restore normal function of tissues and organs. To develop the matrices for use in tissue engineering there are three main groups of biomaterials: (i) naturally derived materials; (ii) synthetic polymers; and (iii) decellularized organ or tissue scaffolds. These biomaterials, in various forms such as hydrogels, nanofibers and 3D scaffolds, among others, have been employed for different tissue regeneration purposes, with several techniques involved in their production, including rapid prototyping, tissue decellularization and electrospinning...
March 30, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29570458/3d-printing-strategies-for-peripheral-nerve-regeneration
#10
Eugen B Petcu, Rajiv Midha, Erin McColl, Aurel Popa-Wagner, Traian V Chirila, Paul D Dalton
After many decades of biomaterials research for peripheral nerve regeneration, a clinical product (the nerve guide), is emerging as a proven alternative for relatively short injury gaps. This review identifies aspects where 3D printing can assist in improving long-distance nerve guide regeneration strategies. These include (1) 3D printing of the customizable nerve guides, (2) fabrication of scaffolds that fill nerve guides, (3) 3D bioprinting of cells within a matrix/bioink into the nerve guide lumen and the (4) establishment of growth factor gradients along the length a nerve guide...
March 23, 2018: Biofabrication
https://www.readbyqxmd.com/read/29563069/biological-evaluation-and-finite-element-modeling-of-porous-poly-para-phenylene-for-orthopaedic-implants
#11
Hyunhee Ahn, Ravi R Patel, Anthony J Hoyt, Angela S P Lin, F Brennan Torstrick, Robert E Guldberg, Carl P Frick, R Dana Carpenter, Christopher M Yakacki, Nick J Willett
Poly(para-phenylene) (PPP) is a novel aromatic polymer with higher strength and stiffness than polyetheretherketone (PEEK), the gold standard material for polymeric load-bearing orthopaedic implants. The amorphous structure of PPP makes it relatively straightforward to manufacture different architectures, while maintaining mechanical properties. PPP is promising as a potential orthopaedic material; however, the biocompatibility and osseointegration have not been well investigated. The objective of this study was to evaluate biological and mechanical behavior of PPP, with or without porosity, in comparison to PEEK...
May 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29558424/3d-printability-of-alginate-carboxymethyl-cellulose-hydrogel
#12
Ahasan Habib, Venkatachalem Sathish, Sanku Mallik, Bashir Khoda
Three-dimensional (3D) bio-printing is a revolutionary technology to reproduce a 3D functional living tissue scaffold in-vitro through controlled layer-by-layer deposition of biomaterials along with high precision positioning of cells. Due to its bio-compatibility, natural hydrogels are commonly considered as the scaffold material. However, the mechanical integrity of a hydrogel material, especially in 3D scaffold architecture, is an issue. In this research, a novel hybrid hydrogel, that is, sodium alginate with carboxymethyl cellulose (CMC) is developed and systematic quantitative characterization tests are conducted to validate its printability, shape fidelity and cell viability...
March 20, 2018: Materials
https://www.readbyqxmd.com/read/29520670/3d-powder-printed-tetracalcium-phosphate-scaffold-with-phytic-acid-binder-fabrication-microstructure-and-in-situ-x-ray-tomography-analysis-of-compressive-failure
#13
Sourav Mandal, Susanne Meininger, Uwe Gbureck, Bikramjit Basu
One of the important aspects in 3D powder printing (3DPP) is the selection of binder for a specific material composition to produce scaffolds with desired microstructure and physico-chemical properties. To this end, a new powder-binder combination, namely tetracalcium phosphate (TTCP) and phytic acid (IP6) was investigated at ambient temperature, for low load bearing application. A minimal deviation (<200 µm, w.r.t. computer aided design) was observed in the final sample through optimization of 3DPP process, along with minimum strut and macro-pore size of 200 and 750 µm, respectively...
March 8, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29519423/fabrication-of-micro-nanoporous-collagen-decm-silk-fibroin-biocomposite-scaffolds-using-a-low-temperature-3d-printing-process-for-bone-tissue-regeneration
#14
Hyeongjin Lee, Gi Hoon Yang, Minseong Kim, JaeYoon Lee, JunTae Huh, GeunHyung Kim
Biomaterials must be biocompatible, biodegradable, and mechanically stable to be used for tissue engineering applications. Among various biomaterials, a natural-based biopolymer, collagen, has been widely applied in tissue engineering because of its outstanding biocompatibility. However, due to its low mechanical properties, collagen has been a challenge to build a desired/complex 3D porous structure with appropriate mechanical strength. To overcome this problem, in this study, we used a low temperature printing process to create a 3D porous scaffold consisting of collagen, decellularized extracellular matrix (dECM) to induce high cellular activities, and silk-fibroin (SF) to attain the proper mechanical strength...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29494503/recent-advances-in-biomaterials-for-3d-printing-and-tissue-engineering
#15
REVIEW
Udayabhanu Jammalamadaka, Karthik Tappa
Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D printing in the field of regenerative medicine and tissue engineering are limited by the variety of biomaterials that can be used in this technology. Many researchers have developed novel biomaterials and compositions to enable their use in 3D printing methods. The advantages of fabricating scaffolds using 3D printing are numerous, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors...
March 1, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#16
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj D Rao, Zhi-Yong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
May 4, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29414913/novel-biomaterials-used-in-medical-3d-printing-techniques
#17
REVIEW
Karthik Tappa, Udayabhanu Jammalamadaka
The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and pharmaceutical fields. A vast variety of biomaterials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. With continuous research and progress in biomaterials used in 3D printing, there has been a rapid growth in applications of 3D printing in manufacturing customized implants, prostheses, drug delivery devices, and 3D scaffolds for tissue engineering and regenerative medicine...
February 7, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29407343/a-bifunctional-scaffold-with-cufese-2-nanocrystals-for-tumor-therapy-and-bone-reconstruction
#18
Wentao Dang, Tao Li, Bo Li, Hongshi Ma, Dong Zhai, Xiaocheng Wang, Jiang Chang, Yin Xiao, Jinwu Wang, Chengtie Wu
Bone tumor is one of major challenging issues clinically. After surgical intervention, a few bone tumor cells still remain around bone defects and then proliferate over days. Fabrication of specific biomaterials with dual functions of bone tumor therapy and bone regeneration is of great significance. In order to achieve this aim, we managed to prepare bioactive glass (BG) scaffolds functionalized by the CuFeSe2 nanocrystals (BG-CFS) by combining 3D printing technique with solvothermal method. During the solvothermal reaction process, CuFeSe2 nanocrystals could in situ grow on the strut surface of BG scaffolds and thus endow BG scaffolds excellent photothermal performance...
January 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29317370/3d-printed-gelatin-scaffolds-of-differing-pore-geometry-modulate-hepatocyte-function-and-gene-expression
#19
Phillip L Lewis, Richard M Green, Ramille N Shah
Three dimensional (3D) printing is highly amenable to the fabrication of tissue-engineered organs of a repetitive microstructure such as the liver. The creation of uniform and geometrically repetitive tissue scaffolds can also allow for the control over cellular aggregation and nutrient diffusion. However, the effect of differing geometries, while controlling for pore size, has yet to be investigated in the context of hepatocyte function. In this study, we show the ability to precisely control pore geometry of 3D-printed gelatin scaffolds...
March 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29282550/bioactive-calcium-silicate-poly-%C3%AE%C2%B5-caprolactone-composite-scaffolds-3d-printed-under-mild-conditions-for-bone-tissue-engineering
#20
Yen-Hong Lin, Yung-Cheng Chiu, Yu-Fang Shen, Yuan-Haw Andrew Wu, Ming-You Shie
The present study provides a solvent-free processing method for establishing the ideal porous 3-dimension (3D) scaffold filled with different ratios of calcium silicate-based (CS) powder and polycaprolactone (PCL) for 3D bone substitute application. Characterization of hybrid scaffolds developed underwent assessments for physicochemical properties and biodegradation. Adhesion and growth of human Wharton's Jelly mesenchymal stem cells (WJMSCs) on the CS/PCL blended scaffold were investigated in vitro. Cell attachment and morphology were examined by scanning electron microscope (SEM) and confocal microscope observations...
December 27, 2017: Journal of Materials Science. Materials in Medicine
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