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3D printed biomaterial scaffold

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https://www.readbyqxmd.com/read/28530207/fabrication-of-biomimetic-bone-grafts-with-multi-material-3d-printing
#1
Nicholas Sears, Prachi Dhavalikar, Michael Whitely, Elizabeth Cosgriff-Hernandez
Extrusion deposition is a versatile method for the 3D printing of biomaterials such as hydrogels, ceramics, and suspensions. Recently, a new class of emulsion inks were developed that can be used to create tunable, hierarchically porous materials with a cure-on-dispense method. Propylene fumarate dimethacrylate (PFDMA) was selected to fabricate bone grafts using this technology due to its established biocompatibility, osteoconductivity, and good compressive properties. Scaffolds fabricated from PFDMA emulsion inks displayed compressive modulus and yield strength of approximately 15 and 1 MPa, respectively...
May 22, 2017: Biofabrication
https://www.readbyqxmd.com/read/28389072/the-characteristics-of-mineral-trioxide-aggregate-polycaprolactone-3-dimensional-scaffold-with-osteogenesis-properties-for-tissue-regeneration
#2
Yung-Cheng Chiu, Hsin-Yuan Fang, Tuan-Ti Hsu, Cheng-Yao Lin, Ming-You Shie
INTRODUCTION: The aim of this study was to investigate whether the mineral trioxide aggregate/polycaprolactone (MTA/PCL) hybrid 3-dimensional (3D) scaffold supplies a suitable microenvironment for the osteogenic differentiation of human dental pulp cells (hDPCs) and to further consider the effect of the MTA/PCL composite on the biological performance of hybrid scaffolds. METHODS: MTA was suspended in absolute alcohol and dropped slowly into PCL that was generated with the printable MTA-matrix...
April 4, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28388393/biomimetic-nanofibrous-scaffolds-for-neural-tissue-engineering-and-drug-development
#3
REVIEW
Jing Wu, Lili Xie, William Zhi Yuan Lin, Qiushui Chen
Neural tissue engineering aims to develop functional substitutes for damaged tissues, creating many promising opportunities in regeneration medicine and drug discovery. Biomaterial scaffolds routinely provide nerve cells with a physical support for cell growth and regeneration, yielding 3D extracellular matrix to mimic the in vivo cellular microenvironment. Among the various types of cellular scaffolds for reconstruction, biomimetic nanofibrous scaffolds are recognized as appropriate candidates by precisely controlling morphology and shape...
April 4, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28351682/two-photon-polymerization-for-production-of-human-ipsc-derived-retinal-cell-grafts
#4
Kristan S Worthington, Luke A Wiley, Emily E Kaalberg, Malia M Collins, Robert F Mullins, Edwin M Stone, Budd A Tucker
Recent advances in induced pluripotent stem cell (iPSC) technology have paved the way for the production of patient-specific neurons that are ideal for autologous cell replacement for treatment of neurodegenerative diseases. In the case of retinal degeneration and associated photoreceptor cell therapy, polymer scaffolds are critical for cellular survival and integration; however, prior attempts to materialize this concept have been unsuccessful in part due to the materials' inability to guide cell alignment...
March 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28337223/emerging-perspectives-in-scaffold-for-tissue-engineering-in-oral-surgery
#5
REVIEW
Gabriele Ceccarelli, Rossella Presta, Laura Benedetti, Maria Gabriella Cusella De Angelis, Saturnino Marco Lupi, Ruggero Rodriguez Y Baena
Bone regeneration is currently one of the most important and challenging tissue engineering approaches in regenerative medicine. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial region. Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28328084/control-of-nanoparticle-release-kinetics-from-3d-printed-hydrogel-scaffolds
#6
Bernhard Baumann, Tomasz Jungst, Simone Stichler, Susanne Feineis, Oliver Wiltschka, Matthias Kuhlmann, Mika Lindén, Jürgen Groll
The convergence of biofabrication with nanotechnology is largely unexplored but enables geometrical control of cell-biomaterial arrangement combined with controlled drug delivery and release. As a step towards integration of these two fields of research, this study demonstrates that modulation of electrostatic nanoparticle-polymer and nanoparticle-nanoparticle interactions can be used for tuning nanoparticle release kinetics from 3D printed hydrogel scaffolds. This generic strategy can be used for spatiotemporal control of the release kinetics of nanoparticulate drug vectors in biofabricated constructs...
April 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28322040/design-and-fabrication-of-a-thin-walled-free-form-scaffold-on-the-basis-of-medical-image-data-and-a-3d-printed-template-its-potential-use-in-bile-duct-regeneration
#7
Suk-Hee Park, Bo-Kyeong Kang, Ji Eun Lee, Seung Woo Chun, Kiseok Jang, Youn Hwan Kim, Mi Ae Jeong, Yohan Kim, Kyojin Kang, Nak Kyu Lee, Dongho Choi, Han Joon Kim
Three-dimensional (3D) printing, combined with medical imaging technologies, such as computed tomography and magnetic resonance imaging (MRI), has shown a great potential in patient-specific tissue regeneration. Here, we successfully fabricated an ultrathin tubular free-form structure with a wall thickness of several tens of micrometers that is capable of providing sufficient mechanical flexibility. Such a thin geometry cannot easily be achieved by 3D printing alone; therefore, it was realized through a serial combination of processes, including the 3D printing of a sacrificial template, the dip coating of the biomaterial, and the removal of the inner template...
March 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28303152/promising-therapeutic-strategies-for-mesenchymal-stem-cell-based-cardiovascular-regeneration-from-cell-priming-to-tissue-engineering
#8
REVIEW
Seung Taek Ji, Hyunyun Kim, Jisoo Yun, Joo Seop Chung, Sang-Mo Kwon
The primary cause of death among chronic diseases worldwide is ischemic cardiovascular diseases, such as stroke and myocardial infarction. Recent evidence indicates that adult stem cell therapies involving cardiovascular regeneration represent promising strategies to treat cardiovascular diseases. Owing to their immunomodulatory properties and vascular repair capabilities, mesenchymal stem cells (MSCs) are strong candidate therapeutic stem cells for use in cardiovascular regeneration. However, major limitations must be overcome, including their very low survival rate in ischemic lesion...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28273799/a-review-of-structure-construction-of-silk-fibroin-biomaterials-from-single-structures-to-multi-level-structures
#9
REVIEW
Yu Qi, Hui Wang, Kai Wei, Ya Yang, Ru-Yue Zheng, Ick Soo Kim, Ke-Qin Zhang
The biological performance of artificial biomaterials is closely related to their structure characteristics. Cell adhesion, migration, proliferation, and differentiation are all strongly affected by the different scale structures of biomaterials. Silk fibroin (SF), extracted mainly from silkworms, has become a popular biomaterial due to its excellent biocompatibility, exceptional mechanical properties, tunable degradation, ease of processing, and sufficient supply. As a material with excellent processability, SF can be processed into various forms with different structures, including particulate, fiber, film, and three-dimensional (3D) porous scaffolds...
March 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28244880/3d-printing-plga-a-quantitative-examination-of-the-effects-of-polymer-composition-and-printing-parameters-on-print-resolution
#10
Ting Guo, Timothy R Holzberg, Casey G Lim, Feng Gao, Ankit Gargava, Jordan E Trachtenberg, Antonios G Mikos, John P Fisher
In the past few decades, 3D printing has played a significant role in fabricating scaffolds with consistent, complex structure that meet patient-specific needs in future clinical applications. Although many studies have contributed to this emerging field of additive manufacturing, which includes material development and computer-aided scaffold design, current quantitative analyses do not correlate material properties, printing parameters, and printing outcomes to a great extent. A model that correlates these properties has tremendous potential to standardize 3D printing for tissue engineering and biomaterial science...
April 12, 2017: Biofabrication
https://www.readbyqxmd.com/read/28194931/influence-of-scaffold-design-on-3d-printed-cell-constructs
#11
Auryn Souness, Fernanda Zamboni, Gavin M Walker, Maurice N Collins
Additive manufacturing is currently receiving significant attention in the field of tissue engineering and biomaterial science. The development of precise, affordable 3D printing technologies has provided a new platform for novel research to be undertaken in 3D scaffold design and fabrication. In the past, a number of 3D scaffold designs have been fabricated to investigate the potential of a 3D printed scaffold as a construct which could support cellular life. These studies have shown promising results; however, few studies have utilized a low-cost desktop 3D printing technology as a potential rapid manufacturing route for different scaffold designs...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28187519/development-of-a-novel-alginate-polyvinyl-alcohol-hydroxyapatite-hydrogel-for-3d-bioprinting-bone-tissue-engineered-scaffolds
#12
Stephanie T Bendtsen, Sean P Quinnell, Mei Wei
Three-dimensional printed biomaterials used as personalized tissue substitutes have the ability to promote and enhance regeneration in areas of defected tissue. The challenge with 3D printing for bone tissue engineering remains the selection of a material with optimal rheological properties for printing in addition to biocompatibility and capacity for uniform cell incorporation. Hydrogel biomaterials may provide sufficient printability to allow cell encapsulation and bioprinting of scaffolds with uniform cell distribution...
May 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28165584/triblock-copolymers-based-on-%C3%AE%C2%B5-caprolactone-and-trimethylene-carbonate-for-the-3d-printing-of-tissue-engineering-scaffolds
#13
Aysun Güney, Jos Malda, Wouter J A Dhert, Dirk W Grijpma
BACKGROUND: Biodegradable PCL-b-PTMC-b-PCL triblock copolymers based on trimethylene carbonate (TMC) and ε-caprolactone (CL) were prepared and used in the 3D printing of tissue engineering scaffolds. Triblock copolymers of various molecular weights containing equal amounts of TMC and CL were prepared. These block copolymers combine the low glass transition temperature of amorphous PTMC (approximately -20°C) and the semi-crystallinity of PCL (glass transition approximately -60°C and melting temperature approximately 60°C)...
May 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28026926/3d-printing-biocompatible-polyurethane-poly-lactic-acid-graphene-oxide-nanocomposites-anisotropic-properties
#14
Qiyi Chen, Joey Dacula Mangadlao, Jaqueline Wallat, Al De Leon, Jonathan K Pokorski, Rigoberto C Advincula
Blending thermoplastic polyurethane (TPU) with poly(lactic acid) (PLA) is a proven method to achieve a much more mechanically robust material, whereas the addition of graphene oxide (GO) is increasingly applied in polymer nanocomposites to tailor further their properties. On the other hand, additive manufacturing has high flexibility of structure design which can significantly expand the application of materials in many fields. This study demonstrates the fused deposition modeling (FDM) 3D printing of TPU/PLA/GO nanocomposites and its potential application as biocompatible materials...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025653/designing-biomaterials-for-3d-printing
#15
Murat Guvendiren, Joseph Molde, Rosane M D Soares, Joachim Kohn
Three-dimensional (3D) printing is becoming an increasingly common technique to fabricate scaffolds and devices for tissue engineering applications. This is due to the potential of 3D printing to provide patient-specific designs, high structural complexity, rapid on-demand fabrication at a low-cost. One of the major bottlenecks that limits the widespread acceptance of 3D printing in biomanufacturing is the lack of diversity in "biomaterial inks". Printability of a biomaterial is determined by the printing technique...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27942578/three-dimensional-printing-of-bone-extracellular-matrix-for-craniofacial-regeneration
#16
Ben P Hung, Bilal A Naved, Ethan L Nyberg, Miguel Dias, Christina A Holmes, Jennifer H Elisseeff, Amir H Dorafshar, Warren L Grayson
Tissue-engineered approaches to regenerate bone in the craniomaxillofacial region utilize biomaterial scaffolds to provide structural and biological cues to stem cells to stimulate osteogenic differentiation. Bioactive scaffolds are typically comprised of natural components but often lack the manufacturability of synthetic materials. To circumvent this trade-off, we 3D printed materials comprised of decellularized bone (DCB) matrix particles combined with polycaprolactone (PCL) to create novel hybrid DCB:PCL scaffolds for bone regeneration...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27940192/3d-bioprinting-of-urethra-with-pcl-plcl-blend-and-dual-autologous-cells-in-fibrin-hydrogel-an-in-vitro-evaluation-of-biomimetic-mechanical-property-and-cell-growth-environment
#17
Kaile Zhang, Qiang Fu, James Yoo, Xiangxian Chen, Prafulla Chandra, Xiumei Mo, Lujie Song, Anthony Atala, Weixin Zhao
OBJECTIVE: Urethral stricture is a common condition seen after urethral injury. The currently available treatments are inadequate and there is a scarcity of substitute materials used for treatment of urethral stricture. The traditional tissue engineering of urethra involves scaffold design, fabrication and processing of multiple cell types. METHODS: In this study, we have used 3D bioprinting technology to fabricate cell-laden urethra in vitro with different polymer types and structural characteristics...
December 8, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-three-dimensional-bioprinting
#18
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live de novo created biosimilar constructs. However, after more than a decade of incubation and many proofs of concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those that followed, were modified versions of the three-dimensional printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
January 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27892655/3d-printed-polycaprolactone-carbon-nanotube-composite-scaffolds-for-cardiac-tissue-engineering
#19
Chee Meng Benjamin Ho, Abhinay Mishra, Pearlyn Teo Pei Lin, Sum Huan Ng, Wai Yee Yeong, Young-Jin Kim, Yong-Jin Yoon
Fabrication of tissue engineering scaffolds with the use of novel 3D printing has gained lot of attention, however systematic investigation of biomaterials for 3D printing have not been widely explored. In this report, well-defined structures of polycaprolactone (PCL) and PCL- carbon nanotube (PCL-CNT) composite scaffolds have been designed and fabricated using a 3D printer. Conditions for 3D printing has been optimized while the effects of varying CNT percentages with PCL matrix on the thermal, mechanical and biological properties of the printed scaffolds are studied...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27877865/three-dimensional-printed-macroporous-polylactic-acid-hydroxyapatite-composite-scaffolds-for-promoting-bone-formation-in-a-critical-size-rat-calvarial-defect-model
#20
Haifeng Zhang, Xiyuan Mao, Zijing Du, Wenbo Jiang, Xiuguo Han, Danyang Zhao, Dong Han, Qingfeng Li
We have explored the applicability of printed scaffold by comparing osteogenic ability and biodegradation property of three resorbable biomaterials. A polylactic acid/hydroxyapatite (PLA/HA) composite with a pore size of 500 μm and 60% porosity was fabricated by three-dimensional printing. Three-dimensional printed PLA/HA, β-tricalcium phosphate (β-TCP) and partially demineralized bone matrix (DBM) seeded with bone marrow stromal cells (BMSCs) were evaluated by cell adhesion, proliferation, alkaline phosphatase activity and osteogenic gene expression of osteopontin (OPN) and collagen type I (COL-1)...
2016: Science and Technology of Advanced Materials
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