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3D printed biomaterial scaffold

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https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#1
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29414913/novel-biomaterials-used-in-medical-3d-printing-techniques
#2
REVIEW
Karthik Tappa, Udayabhanu Jammalamadaka
The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and pharmaceutical fields. A vast variety of biomaterials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. With continuous research and progress in biomaterials used in 3D printing, there has been a rapid growth in applications of 3D printing in manufacturing customized implants, prostheses, drug delivery devices, and 3D scaffolds for tissue engineering and regenerative medicine...
February 7, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29407343/a-bifunctional-scaffold-with-cufese2-nanocrystals-for-tumor-therapy-and-bone-reconstruction
#3
Wentao Dang, Tao Li, Bo Li, Hongshi Ma, Dong Zhai, Xiaocheng Wang, Jiang Chang, Yin Xiao, Jinwu Wang, Chengtie Wu
Bone tumor is one of major challenging issues clinically. After surgical intervention, a few bone tumor cells still remain around bone defects and then proliferate over days. Fabrication of specific biomaterials with dual functions of bone tumor therapy and bone regeneration is of great significance. In order to achieve this aim, we managed to prepare bioactive glass (BG) scaffolds functionalized by the CuFeSe2 nanocrystals (BG-CFS) by combining 3D printing technique with solvothermal method. During the solvothermal reaction process, CuFeSe2 nanocrystals could in situ grow on the strut surface of BG scaffolds and thus endow BG scaffolds excellent photothermal performance...
January 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29317370/3d-printed-gelatin-scaffolds-of-differing-pore-geometry-modulate-hepatocyte-function-and-gene-expression
#4
Phillip L Lewis, Richard M Green, Ramille N Shah
Three dimensional (3D) printing is highly amenable to the fabrication of tissue-engineered organs of a repetitive microstructure such as the liver. The creation of uniform and geometrically repetitive tissue scaffolds can also allow for the control over cellular aggregation and nutrient diffusion. However, the effect of differing geometries, while controlling for pore size, has yet to be investigated in the context of hepatocyte function. In this study, we show the ability to precisely control pore geometry of 3D-printed gelatin scaffolds...
January 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29282550/bioactive-calcium-silicate-poly-%C3%AE%C2%B5-caprolactone-composite-scaffolds-3d-printed-under-mild-conditions-for-bone-tissue-engineering
#5
Yen-Hong Lin, Yung-Cheng Chiu, Yu-Fang Shen, Yuan-Haw Andrew Wu, Ming-You Shie
The present study provides a solvent-free processing method for establishing the ideal porous 3-dimension (3D) scaffold filled with different ratios of calcium silicate-based (CS) powder and polycaprolactone (PCL) for 3D bone substitute application. Characterization of hybrid scaffolds developed underwent assessments for physicochemical properties and biodegradation. Adhesion and growth of human Wharton's Jelly mesenchymal stem cells (WJMSCs) on the CS/PCL blended scaffold were investigated in vitro. Cell attachment and morphology were examined by scanning electron microscope (SEM) and confocal microscope observations...
December 27, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29280325/design-and-structure-function-characterization-of-3d-printed-synthetic-porous-biomaterials-for-tissue-engineering
#6
REVIEW
Cambre N Kelly, Andrew T Miller, Scott J Hollister, Robert E Guldberg, Ken Gall
3D printing is now adopted for use in a variety of industries and functions. In biomedical engineering, 3D printing has prevailed over more traditional manufacturing methods in tissue engineering due to its high degree of control over both macro- and microarchitecture of porous tissue scaffolds. However, with the improved flexibility in design come new challenges in characterizing the structure-function relationships between various architectures and both mechanical and biological properties in an assortment of clinical applications...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29199637/automated-3d-bioassembly-of-micro-tissues-for-biofabrication-of-hybrid-tissue-engineered-constructs
#7
Naveen Vijayan Mekhileri, Khoon Lim, Gabriella C J Brown, Isha Mutreja, Ben S Schon, Gary J Hooper, Tim B F Woodfield
Bottom-up biofabrication approaches combining micro-tissue fabrication techniques with extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in tissue engineering. These biofabrication strategies support native self-assembly mechanisms observed in developmental stages of tissue or organoid growth as well as promoting cell-cell interactions and cell differentiation capacity. Few technologies have been developed to automate the precise assembly of micro-tissues or tissue modules into structural scaffolds...
December 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/29197301/dispensing-based-bioprinting-of-mechanically-functional-hybrid-scaffolds-with-vessel-like-channels-for-tissue-engineering-applications-a-brief-review
#8
REVIEW
Saman Naghieh, Md Sarker, Mohammad Izadifar, Xiongbiao Chen
Over the past decades, significant progress has been achieved in the field of tissue engineering (TE) to restore/repair damaged tissues or organs and, in this regard, scaffolds made from biomaterials have played a critical role. Notably, recent advances in biomaterials and three-dimensional (3D) printing have enabled the manipulation of two or more biomaterials of distinct, yet complementary, mechanical and/or biological properties to form so-called hybrid scaffolds mimicking native tissues. Among various biomaterials, hydrogels synthesized to incorporate living cells and/or biological molecules have dominated due to their hydrated tissue-like environment...
November 26, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29171867/enthusiastic-portrayal-of-3d-bioprinting-in-the-media-ethical-side-effects
#9
Frederic Gilbert, John Noel M Viaña, Cathal D O'Connell, Susan Dodds
There has been a surge in mass media reports extolling the potential for using three-dimensional printing of biomaterials (3D bioprinting) to treat a wide range of clinical conditions. Given that mass media is recognized as one of the most important sources of health and medical information for the general public, especially prospective patients, we report and discuss the ethical consequences of coverage of 3D bioprinting in the media. First, we illustrate how positive mass media narratives of a similar biofabricated technology, namely the Macchiarini scaffold tracheas, which was involved in lethal experimental human trials, influenced potential patient perceptions...
November 24, 2017: Bioethics
https://www.readbyqxmd.com/read/29129026/micromechanical-study-of-the-load-transfer-in-a-polycaprolactone-collagen-hybrid-scaffold-when-subjected-to-unconfined-and-confined-compression
#10
A P G Castro, D Lacroix
Scaffolds are used in diverse tissue engineering applications as hosts for cell proliferation and extracellular matrix formation. One of the most used tissue engineering materials is collagen, which is well known to be a natural biomaterial, also frequently used as cell substrate, given its natural abundance and intrinsic biocompatibility. This study aims to evaluate how the macroscopic biomechanical stimuli applied on a construct made of polycaprolactone scaffold embedded in a collagen substrate translate into microscopic stimuli at the cell level...
November 11, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29128598/histological-and-radiological-evaluation-of-subcutaneous-implants-in-mouse-of-a-3d-printable-material-fulcure-720-and-experimental-application-in-mandibular-reconstruction
#11
J Megías Barrera, L García-Consuegra, A Novoa, S Costilla, S Junquera, G Ascani
INTRODUCTION: The aim of this study was to evaluate the bioactivity of FullCure compared to porous polyethylene implants (Medpor) in rats prior to custom-made scaffold support manufacturing for mandible segmental defects (MSD) reconstruction in sheep. METHODS: 12 Fullcure and Medpor laminaes were implanted in the left and right dorsum respectively of 6 wistar rats. Toxicity was assessed by skin, kidney and liver histopathology 3 months post-implantation. Computed Tomography (CT) was carried out in order to assess radiological differences between implants...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29116737/osteoinduction-by-foamed-and-3d-printed-calcium-phosphate-scaffolds-effect-of-nanostructure-and-pore-architecture
#12
Albert Barba, Anna Diez-Escudero, Yassine Maazouz, Katrin Rappe, Montserrat Espanol, Edgar Benjamín Montufar, Mar Bonany, Joanna Maria Sadowska, Jordi Guillem-Marti, Caroline Öhman-Mägi, Cecilia Persson, Maria-Cristina Manzanares, Jordi Franch, Maria-Pau Ginebra
Some biomaterials are osteoinductive, i.e., they are able to trigger the osteogenic process by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage. Although the underlying mechanism is still unclear, microporosity and specific surface area (SSA) have been identified as critical factors in the material-associated osteoinduction. However, only sintered ceramics, with a limited range of porosities and SSA, have been analysed so far. In this work we were able to extend this range to the nanoscale, through the foaming and 3D-printing of biomimetic calcium phosphates, obtaining scaffolds with controlled micro and nanoporosity together with a tailored macropore architecture...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29106065/fast-setting-silk-fibroin-bioink-for-bioprinting-of-patient-specific-memory-shape-implants
#13
João B Costa, Joana Silva-Correia, Joaquim M Oliveira, Rui L Reis
The pursuit for the "perfect" biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroin (SF) bioink for 3D bioprinting is developed. Their properties are fine-tuned and different structures with good resolution, reproducibility, and reliability can be fabricated. Many potential applications exist for the SF bioinks including 3D bioprinted scaffolds and patient-specific implants exhibiting unique characteristics such as good mechanical properties, memory-shape feature, suitable degradation, and tunable pore architecture and morphology...
November 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29105943/characterization-of-printed-pla-scaffolds-for-bone-tissue-engineering
#14
Agathe Grémare, Vera Guduric, Reine Bareille, Valérie Heroguez, Simon Latour, Nicolas L'heureux, Jean-Christophe Fricain, Sylvain Catros, Damien Le Nihouannen
Autografts remain the gold standard for orthopedic transplantations. However, to overcome its limitations, bone tissue engineering proposes new strategies. This includes the development of new biomaterials such as synthetic polymers, to serve as scaffold for tissue production. The objective of this present study was to produce poly(lactic) acid (PLA) scaffolds of different pore size using fused deposition modeling (FDM) technique and to evaluate their physicochemical and biological properties. Structural, chemical, mechanical, and biological characterizations were performed...
November 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29064532/a-review-of-the-application-of-reinforced-hydrogels-and-silk-as-biomaterials-for-intervertebral-disc-repair
#15
D A Frauchiger, A Tekari, M Wöltje, G Fortunato, L M Benneker, B Gantenbein
The degeneration of the intervertebral disc (IVD) within the spinal column represents a major pain source for many patients. Biological restoration or repair of the IVD using "compressive-force-resistant" and at the same time "cytocompatible" materials would be desirable over current purely mechanical solutions, such as spinal fusion or IVD implants. This review provides an overview of recent research on the repair of the inner (nucleus pulposus = NP) and the outer (annulus fibrous = AF) parts of the IVD tissue...
October 24, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29064377/3d-printing-nano-conductive-multi-walled-carbon-nanotube-scaffolds-for-nerve-regeneration
#16
Se-Jun Lee, Wei Zhu, Margaret Nowicki, Grace Lee, Dong Nyoung Heo, Junghoon Kim, Yi Zuo, Lijie Grace Zhang
In recent years, the development of tissue-engineered 3D scaffolds for various regenerative engineering applications has been widely investigated. Hydrogel polymers are extensively used as tissue engineering scaffold materials due to their unique biocompatible features. However, hydrogel based scaffolds often suffer from weak mechanical strength and a lack of functional groups to enhance cell adhesion. Hence, nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing the interaction between the neural cells and biomaterials...
October 24, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29054525/development-of-a-tannic-acid-cross-linking-process-for-obtaining-3d-porous-cell-laden-collagen-structure
#17
JiUn Lee, Miji Yeo, WonJin Kim, YoungWon Koo, Geun Hyung Kim
Cell-printing is an emerging technique that enables to build a customized structure using biomaterials and living cells for various biomedical applications. In many biomaterials, alginate has been widely used for rapid gelation, low cost, and relatively high processability. However, biocompatibilities enhancing cell adhesion and proliferation were limited, so that, to overcome this problem, an outstanding alternative, collagen, has been extensively investigated. Many factors remain to be proven for cell-printing applications, such as printability, physical sustainability after printing, and applicability of in vitro cell culture...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29025654/3d-printing-hydrogel-with-graphene-oxide-is-functional-in-cartilage-protection-by-influencing-the-signal-pathway-of-rank-rankl-opg
#18
Zhong Cheng, Bolaky Landish, Zhang Chi, Cui Nannan, Du Jingyu, Lu Sen, Lin Xiangjin
3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of a composite 3D printing scaffold, which in turn is relevant to the protection of cartilage. We transplanted rats with hydrogel/GO-np and hydrogel, which in turn showed that hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29020507/custom-repair-of-mandibular-bone-defects-with-3d-printed-bioceramic-scaffolds
#19
H Shao, M Sun, F Zhang, A Liu, Y He, J Fu, X Yang, H Wang, Z Gou
Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular defects in macro and micro, were manufactured by the 3-dimensional (3D) printing technique according to the computed tomography (CT) image. To evaluate the stimulatory effect of the material substrate on bone tissue regeneration in situ in a rabbit mandibular alveolar bone defect model, implants made with the newly developed, mechanically strong ~10% Mg-substituted wollastonite (Ca 90% Mg 10% SiO 3 ; CSi-Mg10) were fabricated, implanted into the bone defects, and compared with implants made with the typical Ca-phosphate and Ca-silicate porous bioceramics, such as β-tricalcium phosphate (TCP), wollastonite (CaSiO 3 ; CSi), and bredigite (Bred)...
January 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/28976740/3d-printed-pericardium-hydrogels-to-promote-wound-healing-in-vascular-applications
#20
Laura G Bracaglia, Michael Messina, Shira Winston, Che-Ying Kuo, Max Lerman, John P Fisher
Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the native vessel. Evidence is emerging that incorporating predetermined building-blocks into a tissue engineering scaffold may oversimplify the environment and ignore critical structures and binding sites essential to development at the implant...
October 16, 2017: Biomacromolecules
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