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3D printed scaffold

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https://www.readbyqxmd.com/read/29782142/projection-based-3d-printing-of-cell-patterning-scaffolds-with-multi-scale-channels
#1
Dai Xue, Yancheng Wang, Jiaxin Zhang, Deqing Mei, Yue Wang, Shaochen Chen
To fully actualize artificial, cell-laden biological models in tissue engineering, such as 3D organoids and organs-on-a-chip systems, cells need to be patterned such that they can precisely mimic natural microenvironments in vitro. Despite increasing interest in this area, patterning cells at multiscales (~10 μm - 10 mm) remains a significant challenge in bioengineering. Here we report a projection-based 3D printing system that achieves rapid and high-resolution fabrication of hydrogel scaffolds featuring intricate channels for multi-scale cell patterning...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29781248/the-role-of-3d-printing-in-treating-craniomaxillofacial-congenital-anomalies
#2
REVIEW
Christopher D Lopez, Lukasz Witek, Andrea Torroni, Roberto L Flores, David B Demissie, Simon Young, Bruce N Cronstein, Paulo G Coelho
Craniomaxillofacial congenital anomalies comprise approximately one third of all congenital birth defects and include deformities such as alveolar clefts, craniosynostosis, and microtia. Current surgical treatments commonly require the use of autogenous graft material which are difficult to shape, limited in supply, associated with donor site morbidity and cannot grow with a maturing skeleton. Our group has demonstrated that 3D printed bio-ceramic scaffolds can generate vascularized bone within large, critical-sized defects (defects too large to heal spontaneously) of the craniomaxillofacial skeleton...
May 20, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29778901/3d-printed-drug-delivery-and-testing-systems-a-passing-fad-or-the-future
#3
Seng Han Lim, Himanshu Kathuria, Justin Jia Yao Tan, Lifeng Kang
The US Food and Drug Administration approval of the first 3D printed tablet in 2015 has ignited growing interest in 3D printing, or additive manufacturing (AM), for drug delivery and testing systems. Beyond just a novel method for rapid prototyping, AM provides key advantages over traditional manufacturing of drug delivery and testing systems. These includes the ability to fabricate complex geometries to achieve variable drug release kinetics; ease of personalising pharmacotherapy for patient and lowering the cost for fabricating personalised dosages...
May 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29763548/zein-increases-the-cytoaffinity-and-biodegradability-of-scaffolds-3d-printed-with-zein-and-poly-%C3%AE%C2%B5-caprolactone-composite-ink
#4
Linzhi Jing, Xiang Wang, Hang Liu, Yuyun Lu, Jinsong Bian, Jie Sun, Dejian Huang
Electrohydrodynamic printing (EHDP) has attracted extensive interests as a powerful technology to fabricate micro to nanoscale fibrous scaffolds in a custom-tailored manner for biomedical applications. A few synthetic biopolymer inks are applicable to this EHDP technology, but the fabricated scaffolds suffered from low mechanical strength, biocompatibility and biodegradability. In this study, a series of poly(ε-caprolactone)(PCL)/zein composite inks were developed and their printability was examined on a solution-based EHDP system for scaffold fabrication...
May 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29756539/skin-regeneration-with-a-scaffold-of-predefined-shape-and-bioactive-peptide-hydrogels
#5
Heejung Im, Su Hee Kim, Soo Hyun Kim, Youngmee Jung
We developed a highly elastic customized scaffold for soft-tissue regeneration and combined them with bioactive hydrogels with stem-cell-inducing ability. This was done to mimic mechanical properties of native soft tissues and improve the viability of transplanted cells as well as efficiency of tissue regeneration. The proposed study was aimed at evaluating various characteristics of scaffolds and investigating their tissue regenerating ability. Finger shaped porous scaffolds were successfully fabricated by an indirect 3D printing of poly (L-lactide-co-ε-caprolactone) (PLCL) which provides a high elasticity for soft tissue engineering...
May 14, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29754201/skin-bioprinting-a-novel-approach-for-creating-artificial-skin-from-synthetic-and-natural-building-blocks
#6
Robin Augustine
Significant progress has been made over the past few decades in the development of in vitro-engineered substitutes that mimic human skin, either as grafts for the replacement of lost skin, or for the establishment of in vitro human skin models. Tissue engineering has been developing as a novel strategy by employing the recent advances in various fields such as polymer engineering, bioengineering, stem cell research and nanomedicine. Recently, an advancement of 3D printing technology referred as bioprinting was exploited to make cell loaded scaffolds to produce constructs which are more matching with the native tissue...
May 12, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29753139/a-review-on-fabricating-tissue-scaffolds-using-vat-photopolymerization
#7
REVIEW
Nicholas A Chartrain, Christopher B Williams, Abby R Whittington
Vat Photopolymerization (stereolithography, SLA), an Additive Manufacturing (AM) or 3D printing technology, holds particular promise for the fabrication of tissue scaffolds for use in regenerative medicine. Unlike traditional tissue scaffold fabrication techniques, SLA is capable of fabricating designed scaffolds through the selective photopolymerization of a photopolymer resin on the micron scale. SLA offers unprecedented control over scaffold porosity and permeability, as well as pore size, shape, and interconnectivity...
May 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29752098/three-dimensional-printing-and-in-vitro-evaluation-of-poly-3-hydroxybutyrate-scaffolds-functionalized-with-osteogenic-growth-peptide-for-tissue-engineering
#8
Sybele Saska, Luana Carla Pires, Mariana Aline Cominotte, Larissa Souza Mendes, Marcelo Fernandes de Oliveira, Izaque Alves Maia, Jorge Vicente Lopes da Silva, Sidney José Lima Ribeiro, Joni Augusto Cirelli
Poly(3-hydroxybutyrate) (PHB) is a biodegradable and thermoprocessable biopolymer, making it a promising candidate for applications in tissue engineering. In the present study a structural characterization and in vitro evaluation were performed on PHB scaffolds produced by additive manufacturing via selective laser sintering (SLS), followed by post-printing functionalization with osteogenic growth peptide (OGP) and its C-terminal sequence OGP(10-14). The PHB scaffolds were characterized, including their morphology, porosity, thermal and mechanical properties, moreover OGP release...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29744467/3d-bioactive-composite-scaffolds-for-bone-tissue-engineering
#9
REVIEW
Gareth Turnbull, Jon Clarke, Frédéric Picard, Philip Riches, Luanluan Jia, Fengxuan Han, Bin Li, Wenmiao Shu
Bone is the second most commonly transplanted tissue worldwide, with over four million operations using bone grafts or bone substitute materials annually to treat bone defects. However, significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma, cancer, infection and arthritis. Developing bioactive three-dimensional (3D) scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering (BTE)...
September 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29744452/3d-bioprinting-for-biomedical-devices-and-tissue-engineering-a-review-of-recent-trends-and-advances
#10
REVIEW
Soroosh Derakhshanfar, Rene Mbeleck, Kaige Xu, Xingying Zhang, Wen Zhong, Malcolm Xing
3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting...
June 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29744431/analysis-of-the-in-vitro-degradation-and-the-in-vivo-tissue-response-to-bi-layered-3d-printed-scaffolds-combining-pla-and-biphasic-pla-bioglass-components-guidance-of-the-inflammatory-response-as-basis-for-osteochondral-regeneration
#11
Mike Barbeck, Tiziano Serra, Patrick Booms, Sanja Stojanovic, Stevo Najman, Elisabeth Engel, Robert Sader, Charles James Kirkpatrick, Melba Navarro, Shahram Ghanaati
The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the (molecular) weight loss and the morphological and mechanical variations after immersion in SBF. The in vivo study focused on analysis of the tissue reactions and differences in the implant bed vascularization using an established subcutaneous implantation model in CD-1 mice and established histological and histomorphometrical methods...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29738294/clinical-application-of-a-3d-printed-scaffold-in-chronic-wound-treatment-a-case-series
#12
Haining Sun, Huayao Lv, Fanghui Qiu, Duolun Sun, Yue Gao, Ning Chen, YongKe Zheng, Kunxue Deng, Yaya Yang, Haitao Zhang, Tao Xu, Dongni Ren
OBJECTIVE: This case series evaluates the safety and effectiveness of 3D-printed scaffold in chronic wounds. The scaffold is a composite of natural and synthetic materials, and can be prepared in the form of powder or membrane. METHOD: We recruited patients with pressure ulcera (PU) and/or a diabetic foot ulcers (DFU). We used two methods: 3D-printed scaffolds alone, or 3D-printing powder mixed with platelet-rich fibrinogen (PRF). Clinicians and patients were asked to rate the scaffold's ease of application and comfort during use...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29732454/chemically-treated-3d-printed-polymer-scaffolds-for-biomineral-formation
#13
Richard J Jackson, P Stephen Patrick, Kristopher Page, Michael J Powell, Mark F Lythgoe, Mark A Miodownik, Ivan P Parkin, Claire J Carmalt, Tammy L Kalber, Joseph C Bear
We present the synthesis of nylon-12 scaffolds by 3D printing and demonstrate their versatility as matrices for cell growth, differentiation, and biomineral formation. We demonstrate that the porous nature of the printed parts makes them ideal for the direct incorporation of preformed nanomaterials or material precursors, leading to nanocomposites with very different properties and environments for cell growth. Additives such as those derived from sources such as tetraethyl orthosilicate applied at a low temperature promote successful cell growth, due partly to the high surface area of the porous matrix...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/29731489/effect-of-oxygen-plasma-etching-on-pore-size-controlled-3d-polycaprolactone-scaffolds-for-enhancing-the-early-new-bone-formation-in-rabbit-calvaria
#14
Min-Suk Kook, Hee-Sang Roh, Byung-Hoon Kim
This study was to investigate the effects of O2 plasma-etching of the 3D polycaprolactone (PCL) scaffold surface on preosteoblast cell proliferation and differentiation, and early new bone formation. The PCL scaffolds were fabricated by 3D printing technique. After O2 plasma treatment, surface characterizations were examined by scanning electron microscopy, atomic force microscopy, and contact angle. MTT assay was used to determine cell proliferation. To investigate the early new bone formation, rabbits were sacrificed at 2 weeks for histological analyses...
May 2, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29729295/electrospinning-an-enabling-nanotechnology-platform-for-drug-delivery-and-regenerative-medicine
#15
Shixuan Chen, Ruiquan Li, Xiaoran Li, Jingwei Xie
Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs...
May 2, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29728785/enhanced-in-vivo-bone-and-blood-vessel-formation-by-iron-oxide-and-silica-doped-3d-printed-tricalcium-phosphate-scaffolds
#16
Susmita Bose, Dishary Banerjee, Samuel Robertson, Sahar Vahabzadeh
Calcium phosphate (CaP) ceramics show significant promise towards bone graft applications because of the compositional similarity to inorganic materials of bone. With 3D printing, it is possible to create ceramic implants that closely mimic the geometry of human bone and can be custom-designed for unusual injuries or anatomical sites. The objective of the study was to optimize the 3D-printing parameters for the fabrication of scaffolds, with complex geometry, made from synthesized tricalcium phosphate (TCP) powder...
May 4, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29728770/zone-dependent-mechanical-properties-of-human-articular-cartilage-obtained-by-indentation-measurements
#17
REVIEW
J Antons, M G M Marascio, J Nohava, R Martin, L A Applegate, P E Bourban, D P Pioletti
Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0...
May 4, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29725268/mesoporous-bioactive-glass-coated-3d-printed-borosilicate-bioactive-glass-scaffolds-for-improving-repair-of-bone-defects
#18
Xin Qi, Hui Wang, Yadong Zhang, Libin Pang, Wei Xiao, Weitao Jia, Shichang Zhao, Deping Wang, Wenhai Huang, Qiugen Wang
Background: In the field of tissue engineering, there is currently increasing interest in new biomedical materials with high osteogenic ability and comparable mechanical function to repair bone defects. Three-dimensional (3-D) bioactive borosilicate glass (BG) scaffolds exhibit uniform interconnected macro-pores, high porosity and high compressive strength. In this study, we fabricated 3-D BG scaffolds by the 3D printing technique, then coated the surface of the 3-D BG scaffolds with mesoporous bioactive glass (MBG) (BG-MBG scaffold)...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29718655/fabrication-of-multiple-layered-hydrogel-scaffolds-with-elaborate-structure-and-good-mechanical-properties-via-3d-printing-and-ionic-reinforcement
#19
Xiaotong Wang, Changzheng Wei, Bin Cao, Lixia Jiang, Yongtai Hou, Jiang Chang
A major challenge in 3D printing of hydrogels is the fabrication of stable constructs with high precision and good mechanical properties and biocompatibility. Existing methods typically feature complicated reinforcement steps or use potentially toxic components, such as photo curing polymers and crosslinking reagents. In this study, we used a thermally sensitive hydrogel, hydroxybutyl chitosan (HBC), for 3D-printing applications. For the first time, we demonstrated that this modified polysaccharide is affected by the specific ion effect...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29717804/three-dimensional-printed-polycaprolactone-microcrystalline-cellulose-scaffolds
#20
Maria Elena Alemán-Domínguez, Elena Giusto, Zaida Ortega, Maryam Tamaddon, Antonio Nizardo Benítez, Chaozong Liu
Microcrystalline cellulose (MCC) is proposed in this study as an additive in polycaprolactone (PCL) matrices to obtain three-dimensional (3D) printed scaffolds with improved mechanical and biological properties. Improving the mechanical behavior and the biological performance of polycaprolactone-based scaffolds allows to increase the potential of these structures for bone tissue engineering. Different groups of samples were evaluated in order to analyze the effect of the additive in the properties of the PCL matrix...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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