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3D printed scaffold

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https://www.readbyqxmd.com/read/28337223/emerging-perspectives-in-scaffold-for-tissue-engineering-in-oral-surgery
#1
REVIEW
Gabriele Ceccarelli, Rossella Presta, Laura Benedetti, Maria Gabriella Cusella De Angelis, Saturnino Marco Lupi, Ruggero Rodriguez Y Baena
Bone regeneration is currently one of the most important and challenging tissue engineering approaches in regenerative medicine. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial region. Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28328084/control-of-nanoparticle-release-kinetics-from-3d-printed-hydrogel-scaffolds
#2
Bernhard Baumann, Tomasz Jungst, Simone Stichler, Susanne Feineis, Oliver Wiltschka, Matthias Kuhlmann, Mika Lindén, Jürgen Groll
The convergence of biofabrication with nanotechnology is largely unexplored but enables geometrical control of cell-biomaterial arrangement combined with controlled drug delivery and release. As a step towards integration of these two fields of research, this study demonstrates that modulation of electrostatic nanoparticle-polymer and nanoparticle-nanoparticle interactions can be used for tuning nanoparticle release kinetics from 3D printed hydrogel scaffolds. This generic strategy can be used for spatiotemporal control of the release kinetics of nanoparticulate drug vectors in biofabricated constructs...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28322040/design-and-fabrication-of-a-thin-walled-freeform-scaffold-on-the-basis-of-medical-image-data-and-a-3d-printed-template-potential-use-in-bile-duct-regeneration
#3
Suk Hee Park, Bo-Kyeong Kang, Ji Eun Lee, Seung Woo Chun, Kiseok Jang, Youn Hwan Kim, Mi Ae Jeong, Yohan Kim, Kyo Jin Kang, Nak Kyu Lee, Dongho Choi, Han Joon Kim
Three-dimensional (3D) printing, combined with medical imaging technologies, such as computed tomography (CT) and magnetic resonance imaging (MRI), has shown great potential in patient-specific tissue regeneration. Here, we successfully fabricated an ultrathin tubular freeform structure that has a wall thickness of several tens of micrometers and is capable of providing sufficient mechanical flexibility. Such a thin geometry cannot easily be achieved by 3D printing alone; therefore, it was realized through a serial combination of processes that included the 3D printing of a sacrificial template, the dip-coating of the biomaterial, and the removal of the inner template...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28303152/promising-therapeutic-strategies-for-mesenchymal-stem-cell-based-cardiovascular-regeneration-from-cell-priming-to-tissue-engineering
#4
REVIEW
Seung Taek Ji, Hyunyun Kim, Jisoo Yun, Joo Seop Chung, Sang-Mo Kwon
The primary cause of death among chronic diseases worldwide is ischemic cardiovascular diseases, such as stroke and myocardial infarction. Recent evidence indicates that adult stem cell therapies involving cardiovascular regeneration represent promising strategies to treat cardiovascular diseases. Owing to their immunomodulatory properties and vascular repair capabilities, mesenchymal stem cells (MSCs) are strong candidate therapeutic stem cells for use in cardiovascular regeneration. However, major limitations must be overcome, including their very low survival rate in ischemic lesion...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28299273/guidelines-for-patient-specific-jawline-definition-with-titanium-implants-in-esthetic-deformity-and-malformation-surgery
#5
Maurice Yves Mommaerts
CONTEXT: Asymmetry and unfavorable esthetics of the jawline have become possible to correct in three dimensions using computer aided design and computer aided manufacturing. AIMS: The aim of this study was to provide esthetic, technical, and operative guidelines for mandibular angle and border augmentation using patient-specific titanium implants made by selective laser melting. SETTINGS AND DESIGN: University hospital - prospective registry...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28294335/a-novel-scale-down-cell-culture-and-imaging-design-for-the-mechanistic-insight-of-cell-colonisation-within-porous-substrate
#6
C M Gabbott, Z X Zhou, G X Han, T Sun
At the core of translational challenges in tissue engineering is the mechanistic understanding of the underpinning biological processes and the complex relationships among components at different levels, which is a challenging task due to the limitations of current tissue culture and assessment methodologies. Therefore, we proposed a novel scale-down strategy to deconstruct complex biomatrices into elementary building blocks, which were resembled by thin modular substrate and then evaluated separately in miniaturised bioreactors using various conventional microscopes...
March 15, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28291335/effect-of-chemical-and-physical-properties-on-the-in-vitro-degradation-of-3d-printed-high-resolution-poly-propylene-fumarate-scaffolds
#7
Jason M Walker, Emily Bodamer, Olivia Krebs, YuanYuan Luo, Alex P Kleinfehn, Matthew L Becker, David Dean
Two distinct molecular masses of poly(propylene fumarate) (PPF) are combined with an additive manufacturing process to fabricate highly complex scaffolds possessing controlled chemical properties and porous architecture. Scaffolds were manufactured with two polymer molecular masses and two architecture styles. Degradation was assessed in an accelerated in vitro environment. The purpose of the degradation study is not to model or mimic in vivo degradation, but to efficiently compare the effect of modulating scaffold properties...
March 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28287077/bone-regeneration-in-3d-printing-bioactive-ceramic-scaffolds-with-improved-tissue-material-interface-pore-architecture-in-thin-wall-bone-defect
#8
Huifeng Shao, Xiurong Ke, An Liu, Miao Sun, Yong He, Xianyan Yang, Jianzhong Fu, Yanming Liu, Lei Zhang, Guojing Yang, Sanzhong Xu, Zhongru Gou
Three-dimensional (3D) printing bioactive ceramics have demonstrated alternative approaches to bone tissue repair, but an optimized materials system for improving the recruitment of host osteogenic cells into the bone defect and enhancing targeted repair of the thin-wall craniomaxillofacial defects remains elusive. Herein we systematically evaluated the role of side-wall pore architecture in the direct-ink-writing bioceramic scaffolds on mechanical properties and osteogenic capacity in rabbit calvarial defects...
March 13, 2017: Biofabrication
https://www.readbyqxmd.com/read/28280669/in-vivo-chondrogenesis-in-3d-bioprinted-human-cell-laden-hydrogel-constructs
#9
Thomas Möller, Matteo Amoroso, Daniel Hägg, Camilla Brantsing, Nicole Rotter, Peter Apelgren, Anders Lindahl, Lars Kölby, Paul Gatenholm
BACKGROUND: The three-dimensional (3D) bioprinting technology allows creation of 3D constructs in a layer-by-layer fashion utilizing biologically relevant materials such as biopolymers and cells. The aim of this study is to investigate the use of 3D bioprinting in a clinically relevant setting to evaluate the potential of this technique for in vivo chondrogenesis. METHODS: Thirty-six nude mice (Balb-C, female) received a 5- × 5- × 1-mm piece of bioprinted cell-laden nanofibrillated cellulose/alginate construct in a subcutaneous pocket...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28278383/3d-printed-poly-%C3%AE%C2%B5-caprolactone-scaffold-augmented-with-mesenchymal-stem-cells-for-total-meniscal-substitution
#10
Zheng-Zheng Zhang, Shao-Jie Wang, Ji-Ying Zhang, Wen-Bo Jiang, Ai-Bing Huang, Yan-Song Qi, Jian-Xun Ding, Xue-Si Chen, Dong Jiang, Jia-Kuo Yu
BACKGROUND: Total meniscectomy leads to knee osteoarthritis in the long term. The poly(ε-caprolactone) (PCL) scaffold is a promising material for meniscal tissue regeneration, but cell-free scaffolds result in relatively poor tissue regeneration and lead to joint degeneration. HYPOTHESIS: A novel, 3-dimensional (3D)-printed PCL scaffold augmented with mesenchymal stem cells (MSCs) would offer benefits in meniscal regeneration and cartilage protection. STUDY DESIGN: Controlled laboratory study...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28273799/a-review-of-structure-construction-of-silk-fibroin-biomaterials-from-single-structures-to-multi-level-structures
#11
REVIEW
Yu Qi, Hui Wang, Kai Wei, Ya Yang, Ru-Yue Zheng, Ick Soo Kim, Ke-Qin Zhang
The biological performance of artificial biomaterials is closely related to their structure characteristics. Cell adhesion, migration, proliferation, and differentiation are all strongly affected by the different scale structures of biomaterials. Silk fibroin (SF), extracted mainly from silkworms, has become a popular biomaterial due to its excellent biocompatibility, exceptional mechanical properties, tunable degradation, ease of processing, and sufficient supply. As a material with excellent processability, SF can be processed into various forms with different structures, including particulate, fiber, film, and three-dimensional (3D) porous scaffolds...
March 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28261331/a-biocompatible-macromolecular-two-photon-initiator-based-on-hyaluronan
#12
Maximilian Tromayer, Peter Gruber, Marica Markovic, Arnulf Rosspeintner, Eric Vauthey, Heinz Redl, Aleksandr Ovsianikov, Robert Liska
The possibility of the direct encapsulation of living cells via two-photon induced photopolymerization enables the microfabrication of hydrogel scaffolds with high initial cell loadings and intimate matrix-cell contact. While highly efficient water-soluble two-photon initiators based on benzylidene ketone dyes have been developed, they exhibit considerable cyto- and phototoxicity. To address the problem of photoinitiator migration from the extracellular matrix into the cytosol, a two-photon initiator bound to a polymeric hyaluronan backbone (HAPI) was synthesized in this work...
January 14, 2017: Polymer Chemistry
https://www.readbyqxmd.com/read/28255127/-progress-in-application-of-3d-bioprinting-in-cartilage-regeneration-and-reconstruction-for-tissue-engineering
#13
Junlin Liao, Shaohua Wang, Jia Chen, Hongju Xie, Jianda Zhou
Three-dimensional (3D) bioprinting provides an advanced technology for tissue engineering and regenerative medicine because of its ability to produce the models or organs with higher precision and more suitable for human body. It has been successfully used to produce a variety of cartilage scaffold materials. In addition, 3D bioprinter can directly to print tissue and organs with live chondrocytes. In conclusion, 3D bioprinting may have broad prospect for cartilage regeneration and reconstruction in tissue engineering...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28254327/addition-of-mgo-nanoparticles-and-plasma-surface-treatment-of-three-dimensional-printed-polycaprolactone-hydroxyapatite-scaffolds-for-improving-bone-regeneration
#14
Hee-Sang Roh, Chang-Min Lee, Young-Hyoun Hwang, Min-Suk Kook, Seong-Won Yang, Donghun Lee, Byung-Hoon Kim
Magnesium (Mg) plays an important role in the body in mediating cell-extracellular matrix interactions and controlling bone apatite structure and density. Hydroxyapatite (HAp) has been used for osteoconductive bone replacement because of its good compressive strength and biocompatibility. The object of this study is to investigate the effects of adding Magnesium oxide (MgO) nanoparticles to polycaprolactone (PCL)/HAp composites and treating PCL/HAp/MgO scaffolds with oxygen and nitrogen plasma. The 3D PCL/HAp/MgO scaffolds were fabricated using a 3D bioextruder...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28251470/3d-printed-porous-titanium-changed-femoral-head-repair-growth-patterns-osteogenesis-and-vascularisation-in-porous-titanium
#15
Wei Zhu, Yan Zhao, Qi Ma, Yingjie Wang, Zhihong Wu, Xisheng Weng
Osteonecrosis of the femoral head (ONFH) is a major cause of morbidity, and total hip arthroplasty is both traumatic and expensive. Here, we created a gelatine scaffold embedded in uniquely shaped, 3D-printed porous titanium parts, which could attract and promote the proliferation of osteoblasts as well as bone regeneration, as the extracellular matrix (ECM) does in vivo. Interestingly, after hybridisation with platelets, the scaffold exhibited a low yet considerable rate of stable, safe and long-term growth factor release...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28244880/3d-printing-plga-a-quantitative-examination-of-the-effects-of-polymer-composition-and-printing-parameters-on-print-resolution
#16
Ting Guo, Timothy Holzberg, Casey Lim, Feng Gao, Ankit Gargava, Jordan Trachtenberg, Antonios Mikos, John Fisher
In the past few decades, 3D printing has played a significant role in fabricating scaffolds with consistent, complex structure that meets patient-specific needs in future clinical applications. Although many studies have contributed to this emerging field of additive manufacturing, which includes material development and computer-aided scaffold design, current quantitative analyses do not correlate material properties, printing parameters, and printing outcomes to a great extent. A model that correlates these properties has tremendous potential to standardize 3D printing for tissue engineering and biomaterial science...
February 28, 2017: Biofabrication
https://www.readbyqxmd.com/read/28229424/three-dimensional-printed-scaffolds-with-multipotent-mesenchymal-stromal-cells-for-rabbit-mandibular-reconstruction-and-engineering
#17
Dongdong Fang, Michael Roskies, Mohamed-Nur Abdallah, Mohammed Bakkar, Jack Jordan, Li-Chieh Lin, Faleh Tamimi, Simon D Tran
Multipotent mesenchymal stromal cells (MSC) derived from both the bone marrow and adipose tissue possess the ability to differentiate into multiple cell lineages, regulate the immune function by secreting numerous bioactive paracrine factors, and hold great potential in cell therapy and tissue engineering. When combined with three-dimensional (3D) scaffolds, MSC can be used for bone defect reconstruction and engineering. This protocol describes the isolation of bone marrow mesenchymal stromal cells (BMMSC) and adipose-tissue derived stem cells (ADSC) from rabbits for subsequent seeding on tissue-engineered 3D-printed scaffolds and transplantation into a rabbit-model with the goal of repairing large osseous mandibular defects (one quarter of the lower jaw is removed surgically)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28211911/three-dimensional-printing-of-calcium-sulfate-and-mesoporous-bioactive-glass-scaffolds-for-improving-bone-regeneration-in-vitro-and-in-vivo
#18
Xin Qi, Peng Pei, Min Zhu, Xiaoyu Du, Chen Xin, Shichang Zhao, Xiaolin Li, Yufang Zhu
In the clinic, bone defects resulting from infections, trauma, surgical resection and genetic malformations remain a significant challenge. In the field of bone tissue engineering, three-dimensional (3D) scaffolds are promising for the treatment of bone defects. In this study, calcium sulfate hydrate (CSH)/mesoporous bioactive glass (MBG) scaffolds were successfully fabricated using a 3D printing technique, which had a regular and uniform square macroporous structure, high porosity and excellent apatite mineralization ability...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203553/three-dimensional-3d-printing-of-mouse-primary-hepatocytes-to-generate-3d-hepatic-structure
#19
Yohan Kim, Kyojin Kang, Jaemin Jeong, Seung Sam Paik, Ji Sook Kim, Su A Park, Wan Doo Kim, Jisun Park, Dongho Choi
PURPOSE: The major problem in producing artificial livers is that primary hepatocytes cannot be cultured for many days. Recently, 3-dimensional (3D) printing technology draws attention and this technology regarded as a useful tool for current cell biology. By using the 3D bio-printing, these problems can be resolved. METHODS: To generate 3D bio-printed structures (25 mm × 25 mm), cells-alginate constructs were fabricated by 3D bio-printing system. Mouse primary hepatocytes were isolated from the livers of 6-8 weeks old mice by a 2-step collagenase method...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28194931/influence-of-scaffold-design-on-3d-printed-cell-constructs
#20
Auryn Souness, Fernanda Zamboni, Gavin M Walker, Maurice N Collins
Additive manufacturing is currently receiving significant attention in the field of tissue engineering and biomaterial science. The development of precise, affordable 3D printing technologies has provided a new platform for novel research to be undertaken in 3D scaffold design and fabrication. In the past, a number of 3D scaffold designs have been fabricated to investigate the potential of a 3D printed scaffold as a construct which could support cellular life. These studies have shown promising results; however, few studies have utilized a low-cost desktop 3D printing technology as a potential rapid manufacturing route for different scaffold designs...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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