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3D printed scaffold

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https://www.readbyqxmd.com/read/28071596/3d-bioprinting-of-gelma-scaffolds-triggers-mineral-deposition-by-primary-human-osteoblasts
#1
Christine McBeth, Jasmin Lauer, Michael Ottersbach, Jennifer Campbell, Andre Sharon, Alexis F Sauer-Budge
Due to its relatively low level of antigenicity and high durability, titanium has successfully been used as the major material for biological implants. However, because the typical interface between titanium and tissue precludes adequate transmission of load into the surrounding bone, over time, load-bearing implants tend to loosen and revision surgeries are required. Osseointegration of titanium implants requires presentation of both biological and mechanical cues that promote attachment of and trigger mineral deposition by osteoblasts...
January 10, 2017: Biofabrication
https://www.readbyqxmd.com/read/28071595/hybrid-3d-2d-printing-for-bone-scaffolds-fabrication
#2
V A Seleznev, V Ya Prinz
It is a well-known fact that bone scaffold topography on micro- and nanometer scale influences the cellular behavior. Nano-scale surface modification of scaffolds allows the modulation of biological activity for enhanced cell differentiation. To date, there has been only a limited success in printing scaffolds with micro- and nano-scale features exposed on the surface. To improve on the currently available imperfect technologies, in our paper we introduce new hybrid technologies based on a combination of 2D (nano imprint) and 3D printing methods...
January 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28069694/myocardial-tissue-engineering-with-cells-derived-from-human-induced-pluripotent-stem-cells-and-a-native-like-high-resolution-3-dimensionally-printed-scaffold
#3
Ling Gao, Molly Kupfer, Jangwook Jung, Libang Yang, Patrick Zhang, Yong Sie, Quyen Tran, Visar Ajeti, Brian Freeman, Vladimir Fast, Paul Campagnola, Brenda Ogle, Jianyi Zhang
RATIONALE: Conventional three-dimensional (3D) printing techniques cannot produce structures of the size at which individual cells interact. OBJECTIVE: Here, we used multiphoton-excited, 3-dimensional printing (MPE-3DP) to generate a native-like, extracellular matrix (ECM) scaffold with submicron resolution, and then seeded the scaffold with cardiomyocytes (CMs), smooth-muscle cells (SMCs), and endothelial cells (ECs) that had been differentiated from human induced-pluripotent stem cells (iPSCs) to generate a human, iPSC-derived cardiac muscle patch (hCMP), which was subsequently evaluated in a murine model of myocardial infarction (MI)...
January 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28054761/engineering-and-design-of-polymeric-shells-inwards-interweaving-polymers-as-multilayer-nanofilm-immobilization-matrix-or-chromatography-resins
#4
Houwen Matthew Pan, Han Yu, Gernot Guigas, Andreas Fery, Matthias Weiss, Volker Patzel, Dieter Wilhelm Trau
Hydrogels with complex internal structures are required for advanced drug delivery systems, tissue engineering or used as inks for 3D printing. However, hydrogels lack the tunability and diversity of polymeric shells and require complicated post-synthesis steps to alter its structure or properties. We report on the first integrated approach to assemble and design polymeric shells to take on various complex structures and functions such as multilayer nanofilms, multi-density immobilization matrix or multi-adhesive chromatography resins via the tuning of four assembly parameters: a) poly(allylamine) (PA) concentration, b) number of poly(allylamine)/poly(styrenesulfonic acid) (PA/PSSA) incubations, c) poly(allylamine) (PA) to poly(ethylene glycol) (PEG) grafting ratio and d) % H2O present during assembly...
January 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28052044/electrohydrodynamic-3d-printing-of-microscale-poly-%C3%AE%C2%B5-caprolactone-scaffolds-with-multi-walled-carbon-nanotubes
#5
Jiankang He, Fangyuan Xu, Ruonan Dong, Baolin Guo, Dichen Li
Electrohydrodynamic 3D printing is a promising strategy to controllably fabricate hierarchical fibrous architectures that mimic the structural organizations of native extracellular matrix. However, most of the existing investigations are mainly based on viscous melted biopolymers which make it difficult to uniformly incorporate bioactive or functional nanobiomaterials into the printed microfibers for functionization. Here we investigated the feasibility of employing solution-based electrohydrodynamic 3D printing to fabricate microscale poly (ε-caprolactone) (PCL) scaffolds with multi-walled carbon nanotubes (MWCNTs)...
January 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28045217/3d-printing-of-aniline-tetramer-grafted-polyethylenimine-and-pluronic-f127-composites-for-electroactive-scaffolds
#6
Shi-Lei Dong, Lu Han, Cai-Xia Du, Xiao-Yu Wang, Lu-Hai Li, Yen Wei
Electroactive hydrogel scaffolds are fabricated by the 3D-printing technique using composites of 30% Pluronic F127 and aniline tetramer-grafted-polyethylenimine (AT-PEI) copolymers with various contents from 2.5% to 10%. The synthesized AT-PEI copolymers can self-assemble into nanoparticles with the diameter of ≈50 nm and display excellent electroactivity due to AT conjugation. The copolymers are then homogeneously distributed into 30% Pluronic F127 solution by virtue of the thermosensitivity of F127, denoted as F/AT-PEI composites...
January 3, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28027692/comparison-of-3d-printed-poly-%C3%AE%C2%B5-caprolactone-scaffolds-functionalized-with-tricalcium-phosphate-hydroxyapatite-bio-oss-or-decellularized-bone-matrix
#7
Ethan Nyberg, Alexandra Rindone, Amir Dorafshar, Warren L Grayson
3D-printing facilitates rapid, custom manufacturing of bone scaffolds with a wide range of material choices. Recent studies have demonstrated the potential for 3D-printing bioactive (i.e. osteo-inductive) scaffolds for use in bone regeneration applications. In this study, we 3D-printed porous poly-ϵ-caprolactone (PCL) scaffolds using a fused deposition modeling (FDM) process and functionalized them with mineral additives that have been widely used commercially and clinically: tricalcium phosphate (TCP), hydroxyapatite (HA), Bio-Oss (BO) or decellularized bone matrix (DCB)...
December 27, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28026926/3d-printing-biocompatible-polyurethane-poly-lactic-acid-graphene-oxide-nanocomposites-anisotropic-properties
#8
Qiyi Chen, Joey Dacula Mangadlao, Jaqueline D Wallat, Al Christopher C de Leon, Jonathan K Pokorski, Rigoberto C Advincula
Blending thermoplastic polyurethane (TPU) with poly (lactic acid) (PLA) is a proven method to achieve a much more mechanically-robust material while the addition of graphene oxide (GO) is increasingly applied in polymer nanocomposites to further tailor their properties. On the other hand, additive manufacturing (AM) has high flexibility of structure design which can significantly expand the application of materials in many fields. This study demonstrates the fused deposition modeling(FDM) 3D printing of TPU/PLA/GO nanocomposites and its potential application as biocompatible materials...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025653/designing-biomaterials-for-3d-printing
#9
Murat Guvendiren, Joseph Molde, Rosane M D Soares, Joachim Kohn
Three-dimensional (3D) printing is becoming an increasingly common technique to fabricate scaffolds and devices for tissue engineering applications. This is due to the potential of 3D printing to provide patient-specific designs, high structural complexity, rapid on-demand fabrication at a low-cost. One of the major bottlenecks that limits the widespread acceptance of 3D printing in biomanufacturing is the lack of diversity in "biomaterial inks". Printability of a biomaterial is determined by the printing technique...
October 10, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28017869/endosteal-like-extracellular-matrix-expression-on-melt-electrospun-written-scaffolds
#10
Maria Lourdes Muerza-Cascante, Ali Shokoohmand, Kiarash Khosrotehrani, David Haylock, Paul D Dalton, Dietmar W Hutmacher, Daniela Loessner
: Tissue engineering technology platforms constitute a unique opportunity to integrate cells and extracellular matrix (ECM) proteins into scaffolds and matrices that mimic the natural microenvironments in vitro. The developments of tissue-engineered 3D models that mimic the endosteal microenvironment enable researchers to discover the causes and improve treatments for blood and immune-related diseases. The aim of this study was to establish a physiologically relevant in vitro model using 3D printed scaffolds to assess the contribution of human cells to the formation of a construct that mimics human endosteum...
December 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28008428/materials-and-scaffolds-in-medical-3d-printing-and-bioprinting-in-the-context-of-bone-regeneration
#11
Martin Heller, Heide-Katharina Bauer, Elisabeth Goetze, Matthias Gielisch, Ibrahim T Ozbolat, Kazim K Moncal, Elias Rizk, Hermann Seitz, Michael Gelinsky, Heinz C Schröder, Xiaohong H Wang, Werner E G Müller, Bilal Al-Nawas
The structural and functional repair of lost bone is still one of the biggest challenges in regenerative medicine. In many cases, autologous bone is used for the reconstruction of bone tissue; however, the availability of autologous material is limited, which always means additional stress to the patient. Due to this, more and more frequently various biocompatible materials are being used instead for bone augmentation. In this context, in order to ensure the structural function of the bone, scaffolds are implanted and fixed into the bone defect, depending on the medical indication...
2016: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28008427/social-and-legal-frame-conditions-for-3d-and-bioprinting-in-medicine
#12
Heide-Katharina Bauer, Martin Heller, Matthias Fink, Daniela Maresch, Johannes Gartner, Ulrich M Gassner, Bilal Al-Nawas
The beginnings of three-dimensional (3D) printing and bioprinting can be traced to as early as 1984. From printing inorganic models for the generation of biologic scaffolds, additive manufacturing (AM) developed to the direct printing of organic materials, including specialized tissues, proteins, and cells. In recent years, these technologies have gained significantly in relevance, and there have been several innovations, especially in the field of regenerative medicine. It is becoming increasingly important to consider the economic and social aspects of AM, particularly in education and information of medical human resources, society, and politics, as well as for the establishment of homogenous, globally adapted legal regulations...
2016: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/27998214/fabrication-of-a-highly-aligned-neural-scaffold-via-a-table-top-stereolithography-3d-printing-and-electrospinning
#13
Se-Jun Lee, Margaret Nowicki, Brent Harris, Lijie Grace Zhang
3D bioprinting is a rapidly emerging technique in the field of tissue engineering to fabricate extremely intricate and complex biomimetic scaffolds in the range of micrometers. Such customized 3D printed constructs can be used for the regeneration of complex tissues such as cartilage, vessels and nerves. However, the 3D printing techniques often offer limited control over the resolution and compromised mechanical properties due to short selection of printable inks. To address these limitation, we combined stereolithography and electrospinning techniques to fabricate a novel 3D biomimetic neural scaffold with a tunable porous structure and embedded aligned fibers...
December 21, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27987760/cell-laden-3d-bioprinting-hydrogel-matrix-depending-on-different-compositions-for-soft-tissue-engineering-characterization-and-evaluation
#14
Jisun Park, Sang Jin Lee, Solchan Chung, Jun Hee Lee, Wan Doo Kim, Jae Young Lee, Su A Park
Cell-printing techniques that can construct three-dimensional (3D) structures with biocompatible materials and cells are of great interest for various biomedical applications, such as tissue engineering and drug-screening studies. For successful cell-printing with cells, bioinks are critical for both the processability of printing and the viability of printed cells. However, the influence of composition on 3D bio-printing with cells has not been well explored. In this study, we investigated different compositions of alginate bioinks by varying the concentrations of high molecular weight alginate (High Alg) and low molecular weight alginate (Low Alg)...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27983789/feasibility-of-spatially-offset-raman-spectroscopy-for-in-vitro-and-in-vivo-monitoring-mineralization-of-bone-tissue-engineering-scaffolds
#15
Zhiyu Liao, Faris Sinjab, Amy Nommeots-Nomm, Julian Jones, Laura Ruiz-Cantu, Jing Yang, Felicity Rose, Ioan Notingher
We investigated the feasibility of using spatially offset Raman spectroscopy (SORS) for nondestructive characterization of bone tissue engineering scaffolds. The deep regions of these scaffolds, or scaffolds implanted subcutaneously in live animals, are typically difficult to measure by confocal Raman spectroscopy techniques because of the limited depth penetration of light caused by the high level of light scattering. Layered samples consisting of bioactive glass foams (IEIC16), three-dimensional (3D)-printed biodegradable poly(lactic-co-glycolic acid) scaffolds (PLGA), and hydroxyapatite powder (HA) were used to mimic nondestructive detection of biomineralization for intact real-size 3D tissue engineering constructs...
December 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27976537/human-skin-3d-bioprinting-using-scaffold-free-approach
#16
Léa J Pourchet, Amélie Thepot, Marion Albouy, Edwin J Courtial, Aurélie Boher, Loïc J Blum, Christophe A Marquette
Organ in vitro synthesis is one of the last bottlenecks between tissue engineering and transplantation of synthetic organs. Bioprinting has proven its capacity to produce 3D objects composed of living cells but highly organized tissues such as full thickness skin (dermis + epidermis) are rarely attained. The focus of the present study is to demonstrate the capability of a newly developed ink formulation and the use of an open source printer, for the production of a really complete skin model. Proofs are given through immunostaining and electronic microscopy that the bioprinted skin presents all characteristics of human skin, both at the molecular and macromolecular level...
December 15, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27973346/3d-bioprinting-of-gelma-scaffolds-triggers-mineral-deposition-by-primary-human-osteoblasts
#17
Christine McBeth, Jasmin Lauer, Michael Ottersbach, Jennifer Campbell, Andre Sharon, Alexis Sauer-Budge
Due to its relatively low level of antigenicity and high durability, titanium has successfully been used as the major material for biological implants. However, because the typical interface between titanium and tissue precludes adequate transmission of load into the surrounding bone, over time, load-bearing implants tend to loosen and revision surgeries are required. Osseointegration of titanium implants requires presentation of both biological and mechanical cues that promote attachment of and trigger mineral deposition by osteoblasts...
December 14, 2016: Biofabrication
https://www.readbyqxmd.com/read/27966623/hybrid-microscaffold-based-3d-bioprinting-of-multi-cellular-constructs-with-high-compressive-strength-a-new-biofabrication-strategy
#18
Yu Jun Tan, Xipeng Tan, Wai Yee Yeong, Shu Beng Tor
A hybrid 3D bioprinting approach using porous microscaffolds and extrusion-based printing method is presented. Bioink constitutes of cell-laden poly(D,L-lactic-co-glycolic acid) (PLGA) porous microspheres with thin encapsulation of agarose-collagen composite hydrogel (AC hydrogel). Highly porous microspheres enable cells to adhere and proliferate before printing. Meanwhile, AC hydrogel allows a smooth delivery of cell-laden microspheres (CLMs), with immediate gelation of construct upon printing on cold build platform...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27959322/hybrid-3d-2d-printing-of-bone-scaffolds-hybrid-3d-2d-printing-methods-for-bone-scaffolds-fabrication
#19
V Ya Prinz, Vladimir Seleznev
It is a well-known fact that bone scaffold topography on micro- and nanometer scale influences the cellular behavior. Nano-scale surface modification of scaffolds allows the modulation of biological activity for enhanced cell differentiation. To date, there has been only a limited success in printing scaffolds with micro- and nano-scale features exposed on the surface. To improve on the currently available imperfect technologies, in our paper we introduce new hybrid technologies based on a combination of 2D (nano imprint) and 3D printing methods...
December 13, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27942578/three-dimensional-printing-of-bone-extracellular-matrix-for-craniofacial-regeneration
#20
Ben P Hung, Bilal A Naved, Ethan L Nyberg, Miguel Dias, Christina A Holmes, Jennifer H Elisseeff, Amir H Dorafshar, Warren L Grayson
Tissue-engineered approaches to regenerate bone in the craniomaxillofacial region utilize biomaterial scaffolds to provide structural and biological cues to stem cells to stimulate osteogenic differentiation. Bioactive scaffolds are typically comprised of natural components but often lack the manufacturability of synthetic materials. To circumvent this trade-off, we 3D printed materials comprised of decellularized bone (DCB) matrix particles combined with polycaprolactone (PCL) to create novel hybrid DCB:PCL scaffolds for bone regeneration...
October 10, 2016: ACS Biomaterials Science & Engineering
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