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https://www.readbyqxmd.com/read/29329889/exploring-individual-adaptations-to-an-anterior-cruciate-ligament-injury-prevention-programme
#1
Aaron S Fox, Jason Bonacci, Scott G McLean, Natalie Saunders
BACKGROUND: Individual responses to anterior cruciate ligament injury prevention programmes (ACL IPPs) have received little attention. This study examined the effects of an ACL IPP on neuromuscular control and lower limb biomechanics during landing at the group and individual levels. METHODS: Sixteen female athletes were randomly allocated to training (n=8) or control (n=8) groups. Electromyography, and three-dimensional kinematic and kinetic data were collected during landing at two testing sessions...
January 9, 2018: Knee
https://www.readbyqxmd.com/read/29328520/dysfunctional-sarcomere-contractility-contributes-to-muscle-weakness-in-acta1-related-nemaline-myopathy-nem3
#2
B Joureau, J M de Winter, S Conijn, S J P Bogaards, I Kovacevic, A Kalganov, M Persson, J Lindqvist, G J M Stienen, T C Irving, W Ma, M Yuen, N F Clarke, D E Rassier, E Malfatti, N B Romero, A H Beggs, C A C Ottenheijm
OBJECTIVE: Nemaline myopathy (NM) is one of the most common congenital non-dystrophic myopathies and is characterized by muscle weakness, often from birth. Mutations in ACTA1 are a frequent cause of NM (i.e. NEM3). ACTA1 encodes alpha-actin 1, the main constituent of the sarcomeric thin filament. The mechanisms by which mutations in ACTA1 contribute to muscle weakness in NEM3 are incompletely understood. We hypothesized that sarcomeric dysfunction contributes to muscle weakness in NEM3 patients...
January 12, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29327240/geriatric-oncology-in-spain-survey-results-and-analysis-of-the-current-situation
#3
R Gironés, I Morilla, C Guillen-Ponce, M D Torregrosa, I Paredero, E Bustamante, S Del Barco, G Soler, B Losada, L Visa, E Llabrés, B Fox, J L Firvida, R Blanco, M Antonio, F Aparisi, M Pi-Figueras, E Gonzalez-Flores, M J Molina-Garrido, J Saldaña
INTRODUCTION: Geriatric oncology (GO) is a discipline that focuses on the management of elderly patients with cancer. The Spanish Society of Medical Oncology (SEOM) created a Working group dedicated to geriatric oncology in February 2016. OBJECTIVES: The main goal of this study was to describe the current situation in Spain regarding the management of elderly cancer patients through an online survey of medical oncologists. METHODS: A descriptive survey was sent to several hospitals by means of the SEOM website...
December 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29325847/amphetamine-induced-striatal-dopamine-release-measured-with-an-agonist-radiotracer-in%C3%A2-schizophrenia
#4
W Gordon Frankle, Jennifer Paris, Michael Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran
BACKGROUND: Receptor imaging studies have reported increased amphetamine-induced dopamine release in subjects with schizophrenia (SCH) relative to healthy control subjects (HCs). A limitation of these studies, performed with D2/3 antagonist radiotracers, is the failure to provide information about D2/3 receptors configured in a state of high affinity for the agonists (i.e., D2/3 receptors coupled to G proteins [D2/3 HIGH]). The endogenous agonist dopamine binds with preference to D2/3 HIGH receptors relative to D2/3 LOW receptors, making it critical to understand the status of D2/3 HIGH receptors in SCH...
December 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29325386/-the-protective-effect-of-the-activation-of-nmdar1-erk1-2-signal-pathway-induced-by-levodopa-on-visual-cortical-neurons-in-monocular-deprivation-rats
#5
X N Sun, H L Wang, G Qiao, J Tao, C Liu, X H Hao
Objective: To investigate the protection effects of the activation of NMDAR1(NMDA receptor 1)/ERK1/2 signal pathway on visual cortex nerve cells induced by levodopa in amblyopia rats. Methods: SD rats of SPF grade, were randomly divided into for groups of 9, group A. Control, B. MD group, C. L-levodopa(20 mg·kg(-1))+MD group, D. H-levodopa (80 mg·kg(-1))+MD group, E. H-levodopa+MD+MK801 group, F. H-levodopa+MD+PD98059 group, G. MD+MK801 group, H. MD+PD98059 group, I. MD+DMSO group. Amblyopia rats were made by suture of the right eye...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29322198/association-of-cardiovascular-biomarkers-with-incident-heart-failure-with-preserved-and-reduced-ejection-fraction
#6
Rudolf A de Boer, Matthew Nayor, Christopher R deFilippi, Danielle Enserro, Vijeta Bhambhani, Jorge R Kizer, Michael J Blaha, Frank P Brouwers, Mary Cushman, Joao A C Lima, Hossein Bahrami, Pim van der Harst, Thomas J Wang, Ron T Gansevoort, Caroline S Fox, Hanna K Gaggin, Willem J Kop, Kiang Liu, Ramachandran S Vasan, Bruce M Psaty, Douglas S Lee, Hans L Hillege, Traci M Bartz, Emelia J Benjamin, Cheeling Chan, Matthew Allison, Julius M Gardin, James L Januzzi, Sanjiv J Shah, Daniel Levy, David M Herrington, Martin G Larson, Wiek H van Gilst, John S Gottdiener, Alain G Bertoni, Jennifer E Ho
Importance: Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart failure subtype are incompletely understood. Objective: To evaluate the associations of 12 cardiovascular biomarkers with incident HFpEF vs HFrEF among adults from the general population. Design, Setting, and Participants: This study included 4 longitudinal community-based cohorts: the Cardiovascular Health Study (1989-1990; 1992-1993 for supplemental African-American cohort), the Framingham Heart Study (1995-1998), the Multi-Ethnic Study of Atherosclerosis (2000-2002), and the Prevention of Renal and Vascular End-stage Disease study (1997-1998)...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29317597/preliminary-evidence-for-genetic-overlap-between-body-mass-index-and-striatal-reward-response
#7
T M Lancaster, I Ihssen, L M Brindley, D E Linden
The reward-processing network is implicated in the aetiology of obesity. Several lines of evidence suggest obesity-linked genetic risk loci (such as DRD2 and FTO) may influence individual variation in body mass index (BMI) through neuropsychological processes reflected in alterations in activation of the striatum during reward processing. However, no study has tested the broader hypotheses that (a) the relationship between BMI and reward-related brain activation (measured through the blood oxygenation-dependent (BOLD) signal) may be observed in a large population study and (b) the overall genetic architecture of these phenotypes overlap, an assumption critical for the progression of imaging genetic studies in obesity research...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29317223/cluster-analysis-of-vulnerable-groups-in-acute-tbi-rehabilitation
#8
Erkut N Kucukboyaci, Coralynn Long, Michelle Smith, Joseph F Rath, Tamara Bushnik
OBJECTIVE: To analyze the complex relationship between various social indicators that contribute to socioeconomic status and healthcare barriers. DESIGN: Cluster analysis of historical patient data obtained from inpatient visits. SETTING: Setting: Inpatient rehabilitation unit in a large, urban university hospital PARTICIPANTS: Adult patients receiving acute inpatient care, predominantly for closed head injury. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: We examined the membership of TBI patients in various "vulnerable group" (VG) clusters (e...
January 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29316357/cerebrovascular-events-in-systemic-lupus-erythematosus
#9
John G Hanly, Qiuju Li, Li Su, Murray B Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, M A Dooley, Kristjan Steinsson, Rosalind Ramsey-Goldman, Asad A Zoma, Susan Manzi, Ola Nived, Andreas Jonsen, Munther A Khamashta, Graciela S Alarcón, Winn Chatham, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Manuel Ramos-Casals, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Soren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Chris Theriault, Vernon Farewell
OBJECTIVE: To determine the frequency, associations and outcomes of cerebrovascular events (CerVEs) in a multi-ethnic/racial, prospective, SLE disease inception cohort. METHODS: Patients were assessed annually for 19 neuropsychiatric (NP) events including 5 types of CerVEs: (i) Stroke; (ii) Transient ischemia; (iii) Chronic multifocal ischemia; (iv) Subarachnoid/intracranial hemorrhage; (v) Sinus thrombosis. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 scores were collected...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29315312/taking-the-metabolic-pulse-of-the-world-s-coral-reefs
#10
Tyler Cyronak, Andreas J Andersson, Chris Langdon, Rebecca Albright, Nicholas R Bates, Ken Caldeira, Renee Carlton, Jorge E Corredor, Rob B Dunbar, Ian Enochs, Jonathan Erez, Bradley D Eyre, Jean-Pierre Gattuso, Dwight Gledhill, Hajime Kayanne, David I Kline, David A Koweek, Coulson Lantz, Boaz Lazar, Derek Manzello, Ashly McMahon, Melissa Meléndez, Heather N Page, Isaac R Santos, Kai G Schulz, Emily Shaw, Jacob Silverman, Atsushi Suzuki, Lida Teneva, Atsushi Watanabe, Shoji Yamamoto
Worldwide, coral reef ecosystems are experiencing increasing pressure from a variety of anthropogenic perturbations including ocean warming and acidification, increased sedimentation, eutrophication, and overfishing, which could shift reefs to a condition of net calcium carbonate (CaCO3) dissolution and erosion. Herein, we determine the net calcification potential and the relative balance of net organic carbon metabolism (net community production; NCP) and net inorganic carbon metabolism (net community calcification; NCC) within 23 coral reef locations across the globe...
2018: PloS One
https://www.readbyqxmd.com/read/29313283/edmonton-obesity-staging-system-among-pediatric-patients-a-validation-and-obesogenic-risk-factor-analysis
#11
M G Grammatikopoulou, M Chourdakis, K Gkiouras, P Roumeli, D Poulimeneas, E Apostolidou, I Chountalas, I Tirodimos, O Filippou, S Papadakou-Lagogianni, T Dardavessis
PURPOSE: The Edmonton Obesity Staging System for Pediatrics (EOSS-P) is a useful tool, delineating different obesity severity tiers associated with distinct treatment barriers. The aim of the study was to apply the EOSS-P on a Greek pediatric cohort and assess risk factors associated with each stage, compared to normal weight controls. METHODS: A total of 361 children (2-14 years old), outpatients of an Athenian hospital, participated in this case-control study by forming two groups: the obese (n = 203) and the normoweight controls (n = 158)...
January 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29312822/effect-of-dark-sweet-cherry-powder-consumption-on-the-gut-microbiota-short-chain-fatty-acids-and-biomarkers-of-gut-health-in-obese-db-db-mice
#12
Jose F Garcia-Mazcorro, Nara N Lage, Susanne Mertens-Talcott, Stephen Talcott, Boon Chew, Scot E Dowd, Jorge R Kawas, Giuliana D Noratto
Cherries are fruits containing fiber and bioactive compounds (e.g., polyphenolics) with the potential of helping patients with diabetes and weight disorders, a phenomenon likely related to changes in the complex host-microbiota milieu. The objective of this study was to investigate the effect of cherry supplementation on the gut bacterial composition, concentrations of caecal short-chain fatty acids (SCFAs) and biomarkers of gut health using an in vivo model of obesity. Obese diabetic (db/db) mice received a supplemented diet with 10% cherry powder (supplemented mice, n = 12) for 12 weeks; obese (n = 10) and lean (n = 10) mice served as controls and received a standard diet without cherry...
2018: PeerJ
https://www.readbyqxmd.com/read/29310535/associations-of-osteoprotegerin-with-coronary-artery-calcification-among-women-with-systemic-lupus-erythematosus-and-healthy-controls
#13
I G Poornima, K Shields, L H Kuller, S M Manzi, R Ramsey-Goldman, C Richardson, E Rhew, D D Dunlop, J Song, D Edmundowicz, G T Kondos, J J Carr, C B Langman, H Price, A H Chung, L B Santelices, R H Mackey
Objective We tested the hypothesis that higher circulating levels of osteoprotegerin (OPG) are related to higher levels of coronary artery calcification (CAC) among women with systemic lupus erythematosus (SLE) compared with healthy controls (HCs). Methods Among 611 women in two age- and race-matched SLE case-control studies, OPG was assayed in stored blood samples (HEARTS: plasma, n cases/controls = 122/124, and SOLVABLE: serum, n cases/controls = 185/180) and CAC was measured by electron beam computed tomography...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29310493/drug-concentrations-and-anti-drug-antibodies-during-treatment-with-biosimilar-infliximab-ct-p13-in-routine-care
#14
B Glintborg, T Kringelbach, N Bolstad, D J Warren, G Eng, I J Sørensen, A G Loft, O Hendricks, Imj Hansen, A Linauskas, H Nordin, S Kristensen, H Lindegaard, D V Jensen, G L Goll, E Høgdall, J Gehin, C Enevold, C H Nielsen, N S Krogh, J S Johansen, M L Hetland
No abstract text is available yet for this article.
January 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29309966/piezometric-level-and-electrical-conductivity-spatiotemporal-monitoring-as-an-instrument-to-design-further-managed-aquifer-recharge-strategies-in-a-complex-estuarial-system-under-anthropogenic-pressure
#15
Victor Hugo R Coelho, Guillaume F Bertrand, Suzana M G L Montenegro, Anderson L R Paiva, Cristiano N Almeida, Carlos O Galvão, Luís Romero Barbosa, Larissa F D R Batista, Eduardo L G A Ferreira
Recife Metropolitan Region (RMR, NE Brazil) lies over a multi-layered aquifer system located in an estuarial area. The region has experienced fast population growth and repeated droughts in the last three decades, which led to unprecedented anthropogenic pressure on groundwater resources because of intense water pumping. Accordingly, scientific and stakeholder communities have been challenged to ensure the maintenance of sustainable groundwater resource by managing all water cycle. Because controlling pumping rates is difficult due to the large number of illegal wells, the Managed Aquifer Recharge (MAR) strategies are now under consideration...
January 5, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29303315/dimensionality-driven-metal-insulator-transition-in-spin-orbit-coupled-sriro_-3
#16
P Schütz, D Di Sante, L Dudy, J Gabel, M Stübinger, M Kamp, Y Huang, M Capone, M-A Husanu, V N Strocov, G Sangiovanni, M Sing, R Claessen
Upon reduction of the film thickness we observe a metal-insulator transition in epitaxially stabilized, spin-orbit-coupled SrIrO_{3} ultrathin films. By comparison of the experimental electronic dispersions with density functional theory at various levels of complexity we identify the leading microscopic mechanisms, i.e., a dimensionality-induced readjustment of octahedral rotations, magnetism, and electronic correlations. The astonishing resemblance of the band structure in the two-dimensional limit to that of bulk Sr_{2}IrO_{4} opens new avenues to unconventional superconductivity by "clean" electron doping through electric field gating...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29303310/enhancement-of-quasistationary-shocks-and-heating-via-temporal-staging-in-a-magnetized-laser-plasma-jet
#17
D P Higginson, B Khiar, G Revet, J Béard, M Blecher, M Borghesi, K Burdonov, S N Chen, E Filippov, D Khaghani, K Naughton, H Pépin, S Pikuz, O Portugall, C Riconda, R Riquier, R Rodriguez, S N Ryazantsev, I Yu Skobelev, A Soloviev, M Starodubtsev, T Vinci, O Willi, A Ciardi, J Fuchs
We investigate the formation of a laser-produced magnetized jet under conditions of a varying mass ejection rate and a varying divergence of the ejected plasma flow. This is done by irradiating a solid target placed in a 20 T magnetic field with, first, a collinear precursor laser pulse (10^{12}  W/cm^{2}) and, then, a main pulse (10^{13}  W/cm^{2}) arriving 9-19 ns later. Varying the time delay between the two pulses is found to control the divergence of the expanding plasma, which is shown to increase the strength of and heating in the conical shock that is responsible for jet collimation...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29303302/observation-of-the-identical-rigidity-dependence-of-he-c-and-o-cosmic-rays-at-high-rigidities-by-the-alpha-magnetic-spectrometer-on-the-international-space-station
#18
M Aguilar, L Ali Cavasonza, B Alpat, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, M Battarbee, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, K F Bindel, V Bindi, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, W J Burger, F Cadoux, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, M J Chae, Y H Chang, A I Chen, G M Chen, H S Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, W Creus, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, O Demakov, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, D D'Urso, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, G Gallucci, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, J Hoffman, T H Hsieh, H Huang, Z C Huang, C Huh, M Incagli, M Ionica, W Y Jang, Yi Jia, H Jinchi, S C Kang, K Kanishev, B Khiali, G N Kim, K S Kim, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, Q Li, T X Li, Y Li, Z H Li, Z Y Li, S Lim, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, V D Lordello, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, V M Mikuni, D C Mo, P Mott, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, F Pilo, C Pizzolotto, V Plyaskin, M Pohl, V Poireau, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, D Son, J W Song, M Tacconi, X W Tang, Z C Tang, D Tescaro, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, C Türkoğlu, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, V Vitale, S Vitillo, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, Z L Weng, K Whitman, H Wu, X Wu, R Q Xiong, W Xu, Q Yan, J Yang, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J Zhang, J H Zhang, S W Zhang, Z Zhang, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×10^{6} helium, 8.4×10^{6} carbon, and 7.0×10^{6} oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29302013/elevated-hla-a-expression-impairs-hiv-control-through-inhibition-of-nkg2a-expressing-cells
#19
Veron Ramsuran, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q Del Prete, Douglas K Schneider, Jeffrey D Lifson, Jacques Fellay, Steven G Deeks, Jeffrey N Martin, James J Goedert, Steven M Wolinsky, Nelson L Michael, Gregory D Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D Walker, Jonathan M Carlson, Mary Carrington
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29300415/physical-performance-and-serum-25-oh-vitamin-d-status-in-community-dwelling-old-mobility-limited-adults-a-cross-sectional-study
#20
Å von Berens, T Cederholm, R A Fielding, T Gustafsson, D Kirn, J Laussen, M Nydahl, T G Travison, K Reid, A Koochek
OBJECTIVES: To examine the potential association between serum 25(OH) vitamin D and the performance on the Short Physical Performance Battery (SPPB) including the sub-components; five repeated chair stands test, 4 meters walk test and balance in older mobility-limited community-dwelling men and women. DESIGN: A cross sectional study was performed in American and Swedish subjects who were examined for potential participation in a combined exercise and nutrition intervention trial...
2018: Journal of Nutrition, Health & Aging
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