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Malorie Simons, Emmanuel Apor, James N Butera, Diana O Treaba
TAFRO syndrome is a rare constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction, and organomegaly. Its pathogenesis involves an excessive and inappropriate cytokine storm, most notably from IL-6, causing multiorgan failure; however, its etiology is undetermined. Starting in 2012, TAFRO syndrome was first identified in Japan as an atypical variant of Castleman's disease. Previous reports include various different treatment protocols with inconsistent survival outcomes...
2016: Case Reports in Hematology
Eiko Ohya, Minoru Mizutani, Haruna Sakaguchi, Takao Sekine
Thrombocytopenia, anasarca, myelofibrosis, renal dysfunction and organomegaly (TAFRO) syndrome is a variant of Castleman's disease recently identified in Japan. A 73-year-old man was diagnosed with TAFRO syndrome according to clinical findings, and his symptoms improved after corticosteroid therapy. Ten months later, lymphadenopathy worsened during tapering of corticosteroids. Histological findings of abdominal lymph nodes showed diffuse large B-cell lymphoma. After 6 cycles of R-CHOP therapy, he has remained in sustained complete remission...
2016: Internal Medicine
Bakir Mehić, Lina Duranović Rayan, Nurija Bilalović, Danina Dohranović Tafro, Ilijaz Pilav
BACKGROUND: Lung cancer is usually presented with cough, dyspnea, pain and weight loss, which is overlapping with symptoms of other lung diseases such as pulmonary fibrosis. Pulmonary fibrosis shows characteristic reticular and nodular pattern, while lung cancers are mostly presented with infiltrative mass, thick-walled cavitations or a solitary nodule with spiculated borders. If the diagnosis is established based on clinical symptoms and CT findings, it would be a misapprehension. CASE PRESENTATION: We report a case of lung adenocarcinoma whose symptoms as well as clinical images overlapped strongly with pulmonary fibrosis...
2016: BMC Cancer
Kentaro Sakashita, Kengo Murata, Yuji Inagaki, Souichi Oota, Mikio Takamori
Thrombocytopenia (T), anasarca (A), myelofibrosis (F), renal dysfunction (R), and organomegaly (O) (TAFRO) syndrome is a variant of multicentric Castleman's disease. We describe here a 57-year-old man who presented with persistent fever, pleural effusion, and ascites. He was negative for human immunodeficiency virus and human herpes virus-8. A computed tomography scan showed an anterior mediastinal mass and small inguinal lymphadenopathy. Although a biopsy of the anterior mediastinum showed fatty tissue infiltrated with CD20 (+) and CD45RO (+) lymphocytes, a biopsy of the left inguinal lymph node revealed a hyaline vascular type of Castleman's disease...
September 2016: Respirology Case Reports
Naruhiko Takasawa, Yukio Sekiguchi, Tsuneyuki Takahashi, Akira Muryoi, Jo Satoh, Takeshi Sasaki
We report a case of a 46-year-old woman with fever, pleural effusion, massive ascites, severe edema, hepatosplenomegaly, elevation of serum creatinine level, proteinuria, and severe thrombocytopenia. Her clinical features were compatible with TAFRO syndrome proposed as a variant of multicentric Castleman's disease, that is occasionally associated with poor prognosis. Treatment with corticosteroid improved her symptoms partially. However, thrombocytopenia, ascites, and edema persisted. The use of cyclosporine A successfully improved her condition, resulting in remission...
July 14, 2016: Modern Rheumatology
Masaaki Nagano, Jun Matsumoto
Multicentric Castleman's disease is a polyclonal lymphoproliferative disorder. Recently, a new variant of the disease was reported and named TAFRO syndrome, an acronym for thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly. A 55-year-old woman presented to our hospital with dyspnea on exertion and high fever. Laboratory tests revealed anemia, thrombocytopenia, and proteinuria. Computed tomography (CT) revealed a large anterior mediastinal mass, mild splenomegaly, bilateral pleural effusion, pericardial effusion, and mild systemic lymphadenopathy...
December 2016: Surgical Case Reports
Akira Tadokoro, Nobuhiro Kanaji, Taiga Hara, Koichi Matsumoto, Tomoya Ishii, Takehiro Takagi, Naoki Watanabe, Nobuyuki Kita, Machi Kawauchi, Masaki Ueno, Norimitsu Kadowaki, Shuji Bandoh
No abstract text is available yet for this article.
September 2016: American Journal of Medicine
Shunichiro Yasuda, Keisuke Tanaka, Ayako Ichikawa, Ken Watanabe, Emi Uchida, Masahide Yamamoto, Kouhei Yamamoto, Daisuke Mizuchi, Osamu Miura, Tetsuya Fukuda
TAFRO (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly) syndrome is an atypical manifestation of Castleman's disease. However, the mechanism underlying this very rare syndrome remains unknown, and there is no established standard treatment. Here we report cases of two young females with TAFRO syndrome who showed similar clinical courses. Both cases showed severe anasarca, ascites, and thrombocytopenia. Although high-dose steroids were ineffective, combination chemotherapy showed remarkable effects...
October 2016: International Journal of Hematology
Sumie Hiramatsu, Koichiro Ohmura, Hideaki Tsuji, Hiroshi Kawabata, Toshiyuki Kitano, Ayuko Sogabe, Motomu Hashimoto, Kosaku Murakami, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Takao Fujii, Akifumi Takaori-Kondo, Tsuneyo Mimori
  TAFRO syndrome is a newly defined disease entity which is characterized by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. A histological pattern of multiple lymphadenopathy of atypical Castleman's disease (CD) is also an important characteristic. A 48-year-old man was referred to our hospital with fever, asthenia, bilateral pleural effusion, ascites, generalized edema, dyspnea, hypoalbuminemia, severe thrombocytopenia, anemia, renal failure and proteinuria, whereas bacterial culture and serological and PCR tests for various viruses were all negative...
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
M Naifar, M Messedi, A Elleuch, M Snoussi, N Gouiaa, M Turki, A Lahiani, T Boudawara, Z Bahloul, F Ayedi
Castleman's disease is a lymphoproliferative disorder characterized by angiofollicular lymph node hyperplasia. Recently, a new variant of multicentric Castleman's disease has been identified in Japan called TAFRO syndrome. It is characterized by a constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction and organomegaly (TAFRO). It is usually associated with polyclonal hyperimmunoglobulinemia. Here, we report the first and unique case of TAFRO syndrome with monoclonal gammapathy...
January 2016: Current Research in Translational Medicine
Yasufumi Masaki, Hiroshi Kawabata, Kazue Takai, Masaru Kojima, Norifumi Tsukamoto, Yasuhito Ishigaki, Nozomu Kurose, Makoto Ide, Jun Murakami, Kenji Nara, Hiroshi Yamamoto, Yoko Ozawa, Hidekazu Takahashi, Katsuhiro Miura, Tsutomu Miyauchi, Shinichirou Yoshida, Akihito Momoi, Nobuyasu Awano, Soichiro Ikushima, Yasunori Ohta, Natsue Furuta, Shino Fujimoto, Haruka Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Yoshimasa Fujita, Toshihiro Fukushima, Shigeo Nakamura, Tomohiro Kinoshita, Sadao Aoki
TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several clinical and pathological characteristics of TAFRO syndrome resemble those of multicentric Castleman disease (MCD), other specific features can differentiate between them. Some TAFRO syndrome patients have been successfully treated with glucocorticoids and/or immunosuppressants, including cyclosporin A, tocilizumab and rituximab, whereas others are refractory to treatment, and eventually succumb to the disease...
June 2016: International Journal of Hematology
Shiho Fujiwara, Hiromi Mochinaga, Hirotomo Nakata, Koichi Ohshima, Masanori Matsumoto, Mitsuhiro Uchiba, Yoshiki Mikami, Hiroyuki Hata, Yutaka Okuno, Hiroaki Mitsuya, Kisato Nosaka
TAFRO syndrome is a rare variant type of multicentric Castleman disease, which is characterized by thrombocytopenia, anasarca, reticulin fibrosis of bone marrow, renal dysfunction and organomegaly. Here, we report a case of TAFRO syndrome that was successfully treated with tocilizumab. A 50-year-old man, who presented with fever, epigastric pain, abdominal fullness, and massive edema of the extremities, was admitted to our hospital. Computed tomography revealed bilateral pleural effusions, ascites, and lymphadenopathy...
June 2016: International Journal of Hematology
Kazuya Sakai, Takeshi Maeda, Akira Kuriyama, Noriaki Shimada, Kenji Notohara, Yasunori Ueda
Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is considered as a unique clinicopathologic variant of multicentric Castleman's disease and is recently reported in Japan. This entity represents a severe inflammatory state leading to organ failures such as severe liver dysfunction seen in our case, and can be treated by immunosuppressive agents, steroids, and cyclosporine shown in several case reports. A systematic review and our case suggest the potential utility of tocilizumab as a treatment for TAFRO syndrome...
February 17, 2016: Modern Rheumatology
Noriko Iwaki, David C Fajgenbaum, Christopher S Nabel, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Isao Yoshida, Hiroshi Moro, Koji Nikkuni, Kazue Takai, Kosei Matsue, Mitsutoshi Kurosawa, Masao Hagihara, Akio Saito, Masataka Okamoto, Kenji Yokota, Shinichiro Hiraiwa, Naoya Nakamura, Shinji Nakao, Tadashi Yoshino, Yasuharu Sato
Multicentric Castleman disease (MCD) describes a heterogeneous group of disorders involving systemic inflammation, characteristic lymph node histopathology, and multi-organ dysfunction because of pathologic hypercytokinemia. Whereas Human Herpes Virus-8 (HHV-8) drives the hypercytokinemia in a cohort of immunocompromised patients, the etiology of HHV-8-negative MCD is idiopathic (iMCD). Recently, a limited series of iMCD cases in Japan sharing a constellation of clinical features, including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O) has been described as TAFRO syndrome...
February 2016: American Journal of Hematology
Yusuke Yamaga, Kiyonobu Tokuyama, Takehiro Kato, Rie Yamada, Masanori Murayama, Tsuneko Ikeda, Noriyoshi Yamakita, Takeshige Kunieda
Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is a unique clinicopathologic variant of multicentric Castleman's disease that has recently been identified in Japan. Previous reports have shown that affected patients typically respond to immunosuppressive therapy, such as prednisolone and tocilizumab. However, the optimal treatment for refractory TAFRO syndrome, which can be fatal, remains unclear. We herein report a case of tocilizumab-resistant TAFRO syndrome successfully treated with cyclosporin A, indicating that cyclosporine A may be an alternative therapy for refractory TAFRO syndrome...
2016: Internal Medicine
Yoko Edahiro, Kunimoto Ichikawa, Yoshitaka Sunami, Michiaki Koike, Norio Komatsu
TAFRO syndrome is a systemic inflammatory disorder characterized by low platelet counts, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly. Patients with TAFRO syndrome occasionally have courses complicated by immunological diseases. Herein, we describe a case of TAFRO syndrome associated with autoimmune hemolytic anemia (AIHA). The patient was admitted because of menorrhagia. She had thrombocytopenia, pleural effusion and ascites, hepatomegaly, and multiple lymphadenopathies. Her symptoms worsened, especially fever, pleural effusion and ascites, and she developed AIHA...
November 2015: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Antonino Carbone, Liron Pantanowitz
No abstract text is available yet for this article.
February 2016: American Journal of Hematology
M Jouvray, L Terriou, V Meignin, B Bouchindhomme, M Jourdain, M Lambert, G Lefevre, E Hachulla, P-Y Hatron, L Galicier, D Launay
INTRODUCTION: Multicentric Castleman's disease can mimic adult-onset Still disease. It is exceptionally associated with anasarca, thrombotic microangiopathy and dysautonomia. CASE REPORT: We report a 32-year-old woman with an association of oligoanuria, anasarca, thrombotic microangiopathy with features compatible with adult-onset Still disease. The outcome was initially favorable with corticosteroids, immunoglobulins and plasmapheresis but with the persistence of relapses marked by severe autonomic syndrome and necessity of high dose corticosteroids...
January 2016: La Revue de Médecine Interne
Yoshinobu Konishi, Satoshi Takahashi, Katsuyuki Nishi, Taro Sakamaki, Sachiko Mitani, Hitomi Kaneko, Chisato Mizutani, Naoya Ukyo, Hirokazu Hirata, Mitsuru Tsudo
Multicentric Castleman's disease is a systemic inflammatory disorder characterized by lymphadenopathy and excessive interleukin-6 production. A unique clinicopathologic variant of multicentric Castleman's disease, TAFRO (i.e., thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly) syndrome, was recently proposed in Japan. Despite the successful use of anti-interleukin-6 therapy in some patients with TAFRO syndrome, not all patients achieve remission. The pathophysiological etiology of and suitable therapeutic strategies for this variant have not been established...
2015: Tohoku Journal of Experimental Medicine
Shotaro Tatekawa, Koji Umemura, Ryuichi Fukuyama, Akio Kohno, Masafumi Taniwaki, Junya Kuroda, Yoshihisa Morishita
TAFRO syndrome have been proposed as a rare variant of Castleman's disease. This article reports a case of a 56-year-old man with TAFRO syndrome who was successfully treated with thalidomide in spite of the refractoriness to prednisolone and tocilizumab. Thalidomide may be one of the treatment options for TAFRO syndrome.
June 2015: Clinical Case Reports
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