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DHEA AND Testosterone

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https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#1
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28076306/parallel-diurnal-fluctuation-of-testosterone-androstenedione-dehydroepiandrosterone-and-17ohprogesterone-as-assessed-in-serum-and-saliva-validation-of-a-novel-liquid-chromatography-tandem-mass-spectrometry-method-for-salivary-steroid-profiling
#2
Marco Mezzullo, Alessia Fazzini, Alessandra Gambineri, Guido Di Dalmazi, Roberta Mazza, Carla Pelusi, Valentina Vicennati, Renato Pasquali, Uberto Pagotto, Flaminia Fanelli
BACKGROUND: Salivary androgen testing represents a valuable source of biological information. However, the proper measurement of such low levels is challenging for direct immunoassays, lacking adequate accuracy. In the last few years, many conflicting findings reporting low correlation with the serum counterparts have hampered the clinical application of salivary androgen testing. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) makes it possible to overcome previous analytical limits, providing new insights in endocrinology practice...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28071011/the-effects-of-a-low-calorie-diet-or-an-isocaloric-diet-combined-with-metformin-on-sex-hormones-in-obese-women-of-child-bearing-age
#3
Ewelina Swora-Cwynar, Magdalena Kujawska-Łuczak, Joanna Suliburska, Julita Reguła, Angelika Kargulewicz, Matylda Kręgielska-Narożna, Emilia Marcinkowska, Alina Kanikowska, Marzena Bielas, Marian Grzymisławski, Paweł Bogdański
BACKGROUND: The influence of weight loss treatment on sex hormones profile has been studied mainly in women with polycystic ovary syndrome (PCOS), but in obese premenopausal women without PCOS it still remains unclear. The aim of the study was to evaluate the effect of two approaches to obesity treatment on the serum level of sex hormones in obese women of child-bearing age without PCOS. METHODS: 77 obese Caucasian women (aged 31.2 ±8.3 years) were randomized into two groups: 39 women received a low-calorie diet (LC) and 38 received an isocaloric diet plus metformin (IM), for 12 weeks...
April 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28056433/pelvic-organ-prolapse-and-endogenous-circulating-sex-steroids-in-postmenopausal-women-a-case-control-study
#4
Barbara Bodner-Adler, Klaus Bodner, Cora Schneidinger, Oliver Kimberger, Ksenia Halpern, Heinz Koelbl, Wolfgang Umek
OBJECTIVE: We compared sex steroid levels of postmenopausal patients with symptomatic pelvic organ prolapse (POP) with postmenopausal matched patients without any sign of POP. Furthermore, we evaluated a possible relationship between sex steroid levels and various urogynecologic parameters in cases with POP. Main outcome of interest were differences in circulating estradiol levels between the two groups. STUDY DESIGN: We conducted a case-control study and 46 postmenopausal women with symptomatic POP≥stage 2 were matched 1:1 with 46 urogynecologic healthy women...
December 26, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28043700/prenatal-di-2-ethylhexyl-phthalate-exposure-and-disruption-of-adrenal-androgens-and-glucocorticoids-levels-in-cord-blood-the-hokkaido-study
#5
Atsuko Araki, Takahiko Mitsui, Houman Goudarzi, Tamie Nakajima, Chihiro Miyashita, Sachiko Itoh, Seiko Sasaki, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
Di(2-ethylhexyl) phthalate (DEHP) is known for its endocrine disrupting properties. We previously demonstrated that prenatal DEHP exposure is associated with decreased progesterone levels and testosterone/estradiol ratio in the cord blood. However, evidence of the effects of prenatal DEHP exposure on adrenal androgen and glucocorticoids in infants is scarce. Thus, the objectives of this study were to investigate the association between prenatal DEHP exposure and adrenal androgen and glucocorticoids, and to discuss its effects on steroid hormone profiles in infants...
December 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28041602/serum-vitamin-d-and-sex-hormones-levels-in-men-and-women-the-multi-ethnic-study-of-atherosclerosis-mesa
#6
Di Zhao, Pamela Ouyang, Ian H de Boer, Pamela L Lutsey, Youssef M K Farag, Eliseo Guallar, David S Siscovick, Wendy S Post, Rita R Kalyani, Kevin L Billups, Erin D Michos
INTRODUCTION: 25-hydroxyvitamin D [25(OH)D] deficiency has been associated with low testosterone levels in men, but there are conflicting reports of its associations with sex hormones in women. Less is known about whether these associations are independent of adiposity and lifestyle factors, and whether they differ by race/ethnicity. AIM: To examine associations of 25(OH)D concentrations with sex hormone levels. METHODS: Cross-sectional analysis of 3017 men and 2929 women in a multi-ethnic cohort...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28008861/delayed-diagnosis-of-a-17-hydroxylase-17-20-lyase-deficient-case-presented-with-46-xy-female-low-normal-potassium-can-alert-clinician
#7
Emine Çamtosun, Zeynep Şıklar, Serdar Ceylaner, Pınar Kocaay, Merih Berberoğlu
17-hydroxylase/17,20-lyase deficiency (17OHD) is a rare autosomal recessive defect in adrenal and gonadal steroidogenesis, causes absence of secondary sexual characteristics frequently associated with hypertension and hyperkalemia. Here we report a 46, XY case, who had normal potassium levels and without hypertension. Here we present a 2,5 years old female admitted with female external genitalia and inguinal swelling. Pathology of biopsy revealed that this gonad is a testis. Karyotype was 46, XY. She had no hypertension and no hypokalemia...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28008755/an-exploratory-analysis-of-the-association-between-levels-of-hormones-implied-in-steroid-biosynthesis-and-activity-of-abiraterone-in-patients-with-metastatic-castration-resistant-prostate-cancer
#8
Valentina Bertaglia, Marcello Tucci, Francesca Vignani, Consuelo Buttigliero, Emiliano Aroasio, Alfredo Berruti, Giorgio V Scagliotti, Massimo DI Maio
BACKGROUND: Abiraterone acetate, approved for patients with metastatic castration-resistant prostate cancer (mCRPC), blocks androgen byosinthesis. We aimed to describe changes determined by abiraterone in hormones implied in steroid biosynthesis, exploring association between hormonal levels and drug activity. METHODS: Patients with mCRPC, receiving standard abiraterone + prednisone after docetaxel failure, were studied. We determined serum levels of progesterone, 17OH-progesterone, cortisol, ACTH, DHEA-sulphate, androstenedione, testosterone, sex hormone-binding globulin, aldosterone, plasma renin activity, and cholesterol, baseline and every 12 weeks...
December 22, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27999117/performance-of-mass-spectrometry-steroid-profiling-for-diagnosis-of-polycystic-ovary-syndrome
#9
D J Handelsman, H J Teede, R Desai, R J Norman, L J Moran
STUDY QUESTION: How well does multi-analyte steroid mass spectrometry (MS) profiling classify women with and without polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Our liquid chromatography MS (LC-MS) steroid profiling only minimally improves discrimination of women with and without PCOS compared with a direct testosterone immunoassay (T_IA) and the free androgen index (FAI). WHAT IS KNOWN ALREADY: Blood testosterone measured by direct (non-extraction) immunoassay overlaps between women with and without PCOS...
December 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27997350/a-low-dose-6-5-mg-of-intravaginal-dhea-permits-a-strictly-local-action-while-maintaining-all-serum-estrogens-or-androgens-as-well-as-their-metabolites-within-normal-values
#10
Fernand Labrie, Céline Martel
OBJECTIVE: Serum concentrations of estradiol (E2) and testosterone (testo) measured by mass spectrometry-based assays should remain below the 95th centile measured at 9.3 pg/mL for E2 and 0.26 ng/mL for testo in normal postmenopausal women in order to avoid the risk of non-physiological systemic exposure to elevated serum concentrations of these two sex steroids. METHODS: Serum E2 and testo, as well as dehydroepiandrosterone (DHEA) and nine of its other metabolites, were measured at 10 time intervals over 24 h on the first and seventh days of daily intravaginal administration of 0...
December 20, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27993552/new-pcos-like-phenotype-in-older-infertile-women-of-likely-autoimmune-adrenal-etiology-with-high-amh-but-low-androgens
#11
Norbert Gleicher, Vitaly A Kushnir, Sarah K Darmon, Qi Wang, Lin Zhang, David F Albertini, David H Barad
How anti-Müllerian hormone (AMH) and testosterone (T) interrelate in infertile women is currently largely unknown. We, therefore, in a retrospective cohort study investigated how infertile women with high-AMH (AMH ≥75th quantile; n=144) and with normal-AMH (25th-75th quantile; n=313), stratified for low-T (total testosterone ≤19.0ng/dL), normal-T (19.0-29.0ng/dL) and high-T (>29.0ng/dL) phenotypically behaved. Patient age, follicle stimulating hormone (FSH), dehyroepiandrosterone (DHEA), DHEA sulphate (DHEAS), cortisol (C), adrenocorticotrophic hormone (ACTH), IVF outcomes, as well as inflammatory and immune panels were then compared between groups, with AMH and T as variables...
December 16, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27992610/maternal-preeclampsia-and-androgens-in-the-offspring-around-puberty-a-follow-up-study
#12
Ingvild V Alsnes, Imre Janszky, Bjørn O Åsvold, Inger Økland, Michele R Forman, Lars J Vatten
BACKGROUND: Children born after preeclampsia may have a dominant androgen profile in puberty compared with other children. Circulating androgen concentrations at 11-12 years of age were compared between offspring born after preeclampsia, and children whose mothers did not have preeclampsia. METHODS: A total of 611 mother-offspring pairs were followed up 11 (daughters) or 12 (sons) years after birth: 218 pairs in the preeclampsia group, and 383 pairs without preeclampsia...
2016: PloS One
https://www.readbyqxmd.com/read/27988267/poor-sleep-quality-predicts-hypogonadal-symptoms-and-sexual-dysfunction-in-male-nonstandard-shift-workers
#13
Alexander W Pastuszak, Young M Moon, Jason Scovell, Justin Badal, Dolores J Lamb, Richard E Link, Larry I Lipshultz
OBJECTIVE: To investigate the impact of sleep quality in hypogonadal symptoms and sexual function in men working nonstandard shifts. MATERIALS AND METHODS: Men treated at a single andrology clinic between July and October 2014 completed questionnaires assessing sleep quality, hypogonadal symptoms (Androgen Deficiency in the Aging Male [ADAM/qADAM]), and sexual function (International Index of Erectile Function [IIEF]). Serum hormone levels were assessed at the time of survey completion...
December 14, 2016: Urology
https://www.readbyqxmd.com/read/27986541/the-influence-of-androgens-on-hibernation-phenology-of-free-living-male-arctic-ground-squirrels
#14
M M Richter, B M Barnes, K M O'Reilly, A M Fenn, C L Buck
Free-living ground squirrel species are sexually dimorphic in hibernation phenology. The underlying causes of these differences are not yet known. Androgens, testosterone (T) in particular, inhibit hibernation. To determine the influence of endogenous androgens on annual timing of hibernation we first measured circulating levels of T and dehydroepiandrosterone (DHEA), an adrenal androgen implicated in non-mating season aggression in other species, in free-living male arctic ground squirrels (Urocitellus parryii, AGS)...
December 13, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27984812/sex-specific-associations-of-testosterone-with-prefrontal-hippocampal-development-and-executive-function
#15
Tuong-Vi Nguyen, Jimin Lew, Matthew D Albaugh, Kelly N Botteron, James J Hudziak, Vladimir S Fonov, D Louis Collins, Simon Ducharme, James T McCracken
Testosterone is thought to play a crucial role in mediating sexual differentiation of brain structures. Examinations of the cognitive effects of testosterone have also shown beneficial and potentially sex-specific effects on executive function and mnemonic processes. Yet these findings remain limited by an incomplete understanding of the critical timing and brain regions most affected by testosterone, the lack of documented links between testosterone-related structural brain changes and cognition, and the difficulty in distinguishing the effects of testosterone from those of related sex steroids such as of estradiol and dehydroepiandrosterone (DHEA)...
December 8, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27941768/androgens-in-women-after-allogeneic-hematopoietic-cell-transplantation-impact-of-chronic-gvhd-and-glucocorticoid-therapy
#16
Y Björk, E Smith Knutsson, C Ankarberg-Lindgren, A-K Broman, I Andersson, L Björkman, J Magnusson, K Bergmark, H Anderson, P-O Andersson, M Brune
Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26)...
December 12, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27934105/simultaneous-analysis-of-free-and-sulfated-steroids-by-liquid-chromatography-mass-spectrometry-with-selective-mass-spectrometric-scan-modes-and-polarity-switching
#17
Su Hyeon Lee, Nanhee Lee, Youngmin Hong, Bong Chul Chung, Man Ho Choi
Sulfated steroids can act as a latent form of active free steroids, coexisting with them in biological specimens. To evaluate the metabolic significance of free and sulfated steroid species, a simultaneous analysis of eight free steroids [cholesterol, pregnenolone, 17α-hydroxypregnenolone, progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone (DHEA), testosterone, and 17β-estradiol] and four biologically relevant sulfated steroids was developed and validated, using selected-ion and multiple-reaction monitoring modes coupled to polarity-switching liquid chromatography/mass spectrometry (LC/MS)...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27933387/effect-of-vitamin-d-on-biochemical-parameters-in-polycystic-ovary-syndrome-women-a-meta-analysis
#18
Yunping Xue, Pengfei Xu, Kai Xue, Xiaoyi Duan, Jian Cao, Ting Luan, Qian Li, Lin Gu
AIM: To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients. MATERIALS AND METHODS: Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D...
December 9, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27911021/a-rapid-and-simple-liquid-chromatography-tandem-mass-spectrometry-method-for-the-measurement-of-testosterone-androstenedione-and-dehydroepiandrosterone-in-human-serum
#19
Wenjuan Xu, Huijun Li, Qing Guan, Ying Shen, Liming Cheng
BACKGROUND: The assay of androgens plays an important role for the differential diagnosis of androgen-related endocrine diseases. We developed a rapid and simple liquid chromatography tandem mass spectrometry (LC-MS/MS) method with small sample volume and simple sample preparation for simultaneous determination of serum testosterone, androstenedione and dehydroepiandrosterone (DHEA) in adults. METHODS: We spiked 100 μL of serum with 200 μL of internal standard solution, which was prepared in methanol, for matrix effect relief and protein precipitation...
December 2, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27901631/11-oxygenated-c19-steroids-are-the-predominant-androgens-in-polycystic-ovary-syndrome
#20
Michael W O'Reilly, Punith Kempegowda, Carl Jenkinson, Angela E Taylor, Jonathan L Quanson, Karl-Heinz Storbeck, Wiebke Arlt
CONTEXT: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS) but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to the androgen excess phenotype in women with PCOS. METHODS: 114 women with PCOS and 49 healthy controls underwent measurement of serum androgens by liquid chromatography-tandem mass spectrometry...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
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