keyword
MENU ▼
Read by QxMD icon Read
search

DHEA AND Testosterone

keyword
https://www.readbyqxmd.com/read/28629254/the-yin-and-yang-of-the-adrenal-and-gonadal-systems-in-elite-military-men
#1
Marcus K Taylor, Lisa M Hernández, Shiloah A Kviatkovsky, Matthew R Schoenherr, Michael S Stone, Paul Sargent
We recently established daily, free-living profiles of the adrenal hormone cortisol, the (primarily adrenal) anabolic precursor dehydroepiandrosterone (DHEA) and the (primarily gonadal) anabolic hormone testosterone in elite military men. A prevailing view is that adrenal and gonadal systems reciprocally modulate each other; however, recent paradigm shifts prompted the characterization of these systems as parallel, cooperative processes (i.e. the "positive coupling" hypothesis). In this study, we tested the positive coupling hypothesis in 57 elite military men by evaluating associations between adrenal and gonadal biomarkers across the day...
June 19, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28620546/ovarian-morphology-is-associated-with-insulin-resistance-in-women-with-polycystic-ovary-syndrome-a-cross-sectional-study
#2
Sara Pittenger Reid, Chia-Ning Kao, Lauri Pasch, Kanade Shinkai, Marcelle I Cedars, Heather G Huddleston
BACKGROUND: Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk. METHODS: This is a cross-sectional study of patients seen in a multidisciplinary PCOS clinic at the University of California at San Francisco between 2006 and 2014...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28616771/androgen-supplementation-improves-some-but-not-all-aspects-of-immune-senescence-in-aged-male-macaques
#3
Maham Rais, Randall M Wilson, Henryk F Urbanski, Ilhem Messaoudi
Aging leads to a progressive decline in immune function commonly referred to as immune senescence, which results in increased incidence and severity of infection. In addition, older males experience a significant disruption in their levels of circulating androgens, notably testosterone and dehydroepiandrosterone (DHEA), which has been linked to sarcopenia, osteoporosis, cardiovascular disease, and diabetes. Since sex steroid levels modulate immune function, it is possible that the age-related decline in androgen levels can also affect immune senescence...
June 14, 2017: GeroScience
https://www.readbyqxmd.com/read/28609669/sex-differences-in-associations-between-white-matter-microstructure-and-gonadal-hormones-in-children-and-adolescents-with-prenatal-alcohol-exposure
#4
K A Uban, M M Herting, J R Wozniak, E R Sowell
Despite accumulating evidence from animal models demonstrating that prenatal alcohol exposure (PAE) results in life-long neuroendocrine dysregulation, very little is known on this topic among humans with fetal alcohol spectrum disorders (FASD). We expected that alterations in gonadal hormones might interfere with the typical development of white matter (WM) myelination, and in a sex-dependent manner, in human adolescents with FASD. In order to investigate this hypothesis, we used diffusion tensor imaging (DTI) to assess: 1) whether or not sex moderates the impact of PAE on WM microstructure; and 2) how gonadal hormones relate to alterations in WM microstructure in children and adolescents affected by PAE...
May 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28598709/an-association-between-bone-mineral-density-and-anabolic-hormones-in-middle-aged-and-elderly-men-with-prediabetes
#5
Michał Rabijewski, Lucyna Papierska, Paweł Piątkiewicz
INTRODUCTION: Prediabetes (PD) leads to reduced testosterone (T) in males, but the association between the anabolic hormones and bone mineral density (BMD) remains unknown. OBJECTIVES: We investigated an association between the anabolic hormones and BMD in middle-aged and elderly men with PD. METHODS: We investigated 84 prediabetic and 56 control men. Total T (TT), calculated free T (cFT), and dehydroepiandrosterone sulfate (DHEAS) were measured, and BMD was assessed using DXA methods...
June 9, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28595797/chromium-supplementation-and-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#6
Siavash Fazelian, Mohamad H Rouhani, Sahar Saraf Bank, Reza Amani
INTRODUCTION: polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Some vitamins and mineral can play role in improvement of PCOS. Chromium (Cr) is an essential element in glucose and insulin homeostasis. However, findings are not consistent regarding PCOS improvement. Therefore, the purpose of this paper was to assess the effect of Cr supplementation in PCOS that have not yet fully been elucidated. METHODS: We searched ISI Web of Science, MEDLINE (1966 to June 2016), Google Scholar databases and Proquest and identified eligible papers and extracted the following terms: total testosterone, DHEAS, insulin sensitivity, fasting glucose, fasting insulin, OGTT 1h glucose, OGTT 2h glucose (mg/dL), LH (mIU/mL), FSH, DHEAS, ferriman-Galwey score (FG score)...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28593921/hyperandrogenism-in-adolescent-girls-relationship-with-the-somatotrophic-axis
#7
María Isabel Hernandez, Patricia López, Ximena Gaete, Claudio Villarroel, Gabriel Cavada, Alejandra Avila, German Iñiguez, Fernando Cassorla
BACKGROUND: During puberty there is a physiologic increase in adrenal and ovarian androgens. It has been suggested that the somatotrophic axis may be related to the development of hyperandrogenism and anovulation in non-obese adult women with polycystic ovarian syndrome (PCOS). The objective of the study was to investigate whether ovarian androgen secretion in young postmenarchal girls is related to the function of their somatotropic axis. METHODS: This was a cross-sectional study of adolescent girls...
May 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28581534/bone-mineralization-and-densitometric-evaluation-of-vertebral-fractures-in-women-6-21-years-after-the-onset-of-anorexia-nervosa-symptoms
#8
Gabriela Jagielska, Jerzy Przedlacki, Zbigniew Bartoszewicz, Agnieszka Kondracka, Agnieszka Butwicka, Ewa Racicka, Olgierd Rowiński, Rafał Brzewski, Tomasz Wolańczyk, Celina Tomaszewicz-Libudzic, Urszula Szymańska
OBJECTIVES: We attempted to assess bone mineralization and the frequency of fractures occurrence in women with a history of treatment of anorexia nervosa (AN) in adolescence. METHODS: 47 women (age 20-36.8 years) were re-examined 6.33-21,2 years after the onset of AN symptoms. Bone mineral density (BMD) of total body, lumbar spine, femoral neck, total hip (DXA) and densitometric Vertebral Fracture Assessment (VFA) were performed on 46 of women and BAP, P1NP, CTX, estradiol, testosterone, cortisol, IGF-1, leptin, DHEA-S on 45 of women entered for the current study...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28575537/association-between-biochemical-hyperandrogenism-parameters-and-ferriman-gallwey-score-in-patients-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-regression-analysis
#9
Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Razieh Bidhendi Yarandi, Samira Behboudi-Gandevani, Fereidoun Azizi
BACKGROUND AND OBJECTIVE: A limited number of studies have evaluated the relationship between clinical and biochemical hyperandrogenism (HA). This study aimed to evaluate the association between biochemical hyperandrogenism parameters (BHPs) and Ferriman-Gallwey (FG) score in patients with polycystic ovary syndrome (PCOS). METHODS: We searched PubMed, Scopus, Google Scholar, ScienceDirect and Web of Sciences databases (2000 to 2015) to identify studies investigating clinical and biochemical parameters of HA in PCOS patients...
June 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28559995/cryptotanshinone-reverses-reproductive-disturbances-in-rats-with-dehydroepiandrosterone-induced-polycystic-ovary-syndrome
#10
Yanqiu Xia, Pei Zhao, Hongli Huang, Yuan Xie, Rong Lu, Li Dong
Polycystic ovarian syndrome (PCOS), with a prevalence of 5-8%, is the most common endocrine disorder in women of reproductive age. Although cryptotanshinone (CRY) has been shown to effectively reverse reproductive disturbances, it remains poorly understood whether it can be used to treat PCOS. Here we used an established rat model of PCOS. Prepubertal female Sprague-Dawley rats were subcutaneously injected with dehydroepiandrosterone (DHEA) 60 mg/kg/day for 3 weeks. Those in the DHEA group were given normal saline, while the CRY group was given 27 mg/kg by gastrogavage for 3 weeks...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28553251/no-difference-in-mood-and-quality-of-life-in-dhea-s-deficient-adults-with-addison-s-disease-vs-type-2-diabetes-patients-with-normal-dhea-s-levels-implications-for-management-of-these-conditions
#11
Adrian H Heald, Andreas Walther, Julian R E Davis, Gabriela Y C Moreno, John Kane, Mark Livingston, Helen L Fowler
Patients with Addison's disease have relatively high rates of depression and anxiety symptoms compared with population-based reference samples. Addison's disease results in deficiency of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S). There is considerable debate about the specific effects of DHEA deficiency on energy level and mood. We measured emotional well-being in 16 patients with Addison's disease and a group of 16 hospital attendees with type 2 diabetes. Participants completed the General Health Questionnaire-28 (GHQ-28), the Hospital Anxiety and Depression Scale (HADS), the World Health Organization's quality of life assessment (WHOQOL-BREF) and the Holmes-Rahe life event scale...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28546815/role-of-statin-drugs-for-polycystic-ovary-syndrome
#12
REVIEW
Lisa Cassidy-Vu, Edwina Joe, Julienne K Kirk
Objective: To review the potential role and specific impact of statin drugs in women with PCOS. The evidence for this use of statins in PCOS is limited and still under further investigation. Materials and methods: A search was conducted using PubMed, DynaMed and PubMedHealth databases through October 16, 2016 using the terms polycystic ovary syndrome, PCOS, hydroxymethylglutaryl-CoA reductase inhibitors, hydroxymethylglutaryl-CoA, statin, atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28539251/anabolic-hormone-profiles-in-elite-military-men-robust-associations-with-age-stress-and-fatigue
#13
Marcus K Taylor, Genieleah A Padilla, Lisa M Hernández
We recently established stable daily profiles of the anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in 57 elite military men. In this follow-on study, we explored associations of salivary anabolic hormone profiles with demographic (i.e., age, body mass index [BMI]) and biobehavioral health indices (i.e., blood pressure, sleep, perceived stress, fatigue) via correlational models. Next, nuanced patterns were constructed using quartile splits followed by one-way analysis of variance and post hoc subgroup comparisons...
May 21, 2017: Steroids
https://www.readbyqxmd.com/read/28533544/sex-specific-metabolic-profiles-of-androgens-and-its-main-binding-protein-shbg-in-a-middle-aged-population-without-diabetes
#14
Uwe Piontek, Henri Wallaschofski, Gabi Kastenmüller, Karsten Suhre, Henry Völzke, Kieu Trinh Do, Anna Artati, Matthias Nauck, Jerzy Adamski, Nele Friedrich, Maik Pietzner
The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20-80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28525998/androsterone-glucuronide-to-dehydroepiandrosterone-sulphate-ratio-is-discriminatory-for-obese-caucasian-women-with-polycystic-ovary-syndrome
#15
Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed, Stephen L Atkin
BACKGROUND: Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may differ, this study compared the different androgen parameters in non-obese compared to obese women with PCOS, and in normal subjects. METHODS: Eleven non-obese and 14 obese women with PCOS were recruited and compared to 11 control women without PCOS...
May 19, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28524342/the-effect-of-vitamin-d-supplementation-on-hormonal-and-glycaemic-profile-of-patients-with-pcos-a-meta-analysis-of-randomised-trials
#16
Vasilios Pergialiotis, Nikoleta Karampetsou, Periklis Panagopoulos, Eftihios Trakakis, Nikolaos Papantoniou
BACKGROUND: Vitamin D deficiency is frequently manifested in women with polycystic ovarian syndrome (PCOS). To date, supplementation of deficient patients has not been correlated with the hormonal and metabolic status of these patients. PURPOSE: We aimed to investigate the impact of vitamin D supplementation on the hormonal and metabolic profile of PCOS women. MATERIALS AND METHODS: We searched Medline, Scopus, ClinicalTrials.gov and Cochrane Central Register databases for published randomised controlled trials...
May 19, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28508601/effects-of-anorexia-nervosa-on-the-endocrine-system
#17
Charumathi Baskaran, Madhusmita Misra, Anne Klibanski
Anorexia nervosa (AN) is characterized by severe undernutrition associated with alterations in multiple endocrine axes, which are primarily adaptive to the state of caloric deprivation. Hormonal changes include growth hormone (GH) resistance with low insulin like growth factor-1 (IGF-1) levels, hypothalamic hypogonadism, relative hypercortisolemia and changes in appetite regulating hormones, including leptin, ghrelin, and peptide YY. These alterations contribute to abnormalities in bone metabolism leading to low bone mass, impaired bone microarchitecture, and increased risk for fracture, and may also negatively impact cognition, emotions and mood...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28495656/dehydroepiandrosterone-sulfate-augments-blood-brain-barrier-and-tight-junction-protein-expression-in-brain-endothelial-cells
#18
Dimitrios Papadopoulos, Georgios Scheiner-Bobis
Tight junctions (TJ) between brain endothelial cells are essential for formation and maintenance of the blood-brain barrier (BBB). Although loss of BBB integrity is associated with several neuropathological disorders, treatments that augment or stabilise the BBB are scarce. Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 in the brain-derived endothelial cell line bEnd.3 and promote TJ formation between neighbouring cells, demonstrated by augmented transendothelial resistance across cell monolayers...
May 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28489322/developmental-effects-of-androgens-in-the-human-brain
#19
REVIEW
Tuong-Vi Nguyen
Neuroendocrine theories of brain development posit that androgens play a crucial role in sex-specific cortical growth, but little is known about the differential effects of testosterone and dehydroepiandrosterone (DHEA) on cortico-limbic development and cognition during adolescence. In this context, the NIH Study of Normal Brain Development, a longitudinal study of typically developing children and adolescents 4 to 24 years of age (n=433), offered a unique opportunity to examine the developmental effects of androgens on cortico-limbic maturation and cognition...
May 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28472898/the-relation-among-steroid-hormone-levels-lipid-profile-and-menopausal-symptom-severity
#20
Cihan Kaya, Hüseyin Cengiz, Ali Yeşil, Murat Ekin, Levent Yaşar
INTRODUCTION: Many postmenopausal women experience hot flashes, night sweats, non-specific emotional and psychological distresses. Our aim was to investigate the relation among steroid hormone levels, lipid profile and menopausal symptom severity using the menopause rating scale (MRS). METHODS: A cross-sectional study was performed at our outpatient clinic with natural postmenopausal women. A total of 444 women were included in this study. The basic characteristics of the study population, such as age, gravidity, parity, time to menopause onset and body mass index (BMI) were recorded...
May 4, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
keyword
keyword
103036
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"