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https://www.readbyqxmd.com/read/28546815/role-of-statin-drugs-for-polycystic-ovary-syndrome
#1
REVIEW
Lisa Cassidy-Vu, Edwina Joe, Julienne K Kirk
Objective: To review the potential role and specific impact of statin drugs in women with PCOS. The evidence for this use of statins in PCOS is limited and still under further investigation. Materials and methods: A search was conducted using PubMed, DynaMed and PubMedHealth databases through October 16, 2016 using the terms polycystic ovary syndrome, PCOS, hydroxymethylglutaryl-CoA reductase inhibitors, hydroxymethylglutaryl-CoA, statin, atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28539251/anabolic-hormone-profiles-in-elite-military-men-robust-associations-with-age-stress-and-fatigue
#2
Marcus K Taylor, Genieleah A Padilla, Lisa M Hernández
We recently established stable daily profiles of the anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in 57 elite military men. In this follow-on study, we explored associations of salivary anabolic hormone profiles with demographic (i.e., age, body mass index [BMI]) and biobehavioral health indices (i.e., blood pressure, sleep, perceived stress, fatigue) via correlational models. Next, nuanced patterns were constructed using quartile splits followed by one-way analysis of variance and post hoc subgroup comparisons...
May 21, 2017: Steroids
https://www.readbyqxmd.com/read/28533544/sex-specific-metabolic-profiles-of-androgens-and-its-main-binding-protein-shbg-in-a-middle-aged-population-without-diabetes
#3
Uwe Piontek, Henri Wallaschofski, Gabi Kastenmüller, Karsten Suhre, Henry Völzke, Kieu Trinh Do, Anna Artati, Matthias Nauck, Jerzy Adamski, Nele Friedrich, Maik Pietzner
The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20-80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28525998/androsterone-glucuronide-to-dehydroepiandrosterone-sulphate-ratio-is-discriminatory-for-obese-caucasian-women-with-polycystic-ovary-syndrome
#4
Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed, Stephen L Atkin
BACKGROUND: Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may differ, this study compared the different androgen parameters in non-obese compared to obese women with PCOS, and in normal subjects. METHODS: Eleven non-obese and 14 obese women with PCOS were recruited and compared to 11 control women without PCOS...
May 19, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28524342/the-effect-of-vitamin-d-supplementation-on-hormonal-and-glycaemic-profile-of-patients-with-pcos-a-meta-analysis-of-randomised-trials
#5
Vasilios Pergialiotis, Nikoleta Karampetsou, Periklis Panagopoulos, Eftihios Trakakis, Nikolaos Papantoniou
BACKGROUND: Vitamin D deficiency is frequently manifested in women with polycystic ovarian syndrome (PCOS). To date, supplementation of deficient patients has not been correlated with the hormonal and metabolic status of these patients. PURPOSE: We aimed to investigate the impact of vitamin D supplementation on the hormonal and metabolic profile of PCOS women. MATERIALS AND METHODS: We searched Medline, Scopus, ClinicalTrials.gov and Cochrane Central Register databases for published randomised controlled trials...
May 19, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28508601/effects-of-anorexia-nervosa-on-the-endocrine-system
#6
Charumathi Baskaran, Madhusmita Misra, Anne Klibanski
Anorexia nervosa (AN) is characterized by severe undernutrition associated with alterations in multiple endocrine axes, which are primarily adaptive to the state of caloric deprivation. Hormonal changes include growth hormone (GH) resistance with low insulin like growth factor-1 (IGF-1) levels, hypothalamic hypogonadism, relative hypercortisolemia and changes in appetite regulating hormones, including leptin, ghrelin, and peptide YY. These alterations contribute to abnormalities in bone metabolism leading to low bone mass, impaired bone microarchitecture, and increased risk for fracture, and may also negatively impact cognition, emotions and mood...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28495656/dehydroepiandrosterone-sulfate-augments-blood-brain-barrier-and-tight-junction-protein-expression-in-brain-endothelial-cells
#7
Dimitrios Papadopoulos, Georgios Scheiner-Bobis
Tight junctions (TJ) between brain endothelial cells are essential for formation and maintenance of the blood-brain barrier (BBB). Although loss of BBB integrity is associated with several neuropathological disorders, treatments that augment or stabilise the BBB are scarce. Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 in the brain-derived endothelial cell line bEnd.3 and promote TJ formation between neighbouring cells, demonstrated by augmented transendothelial resistance across cell monolayers...
May 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28489322/developmental-effects-of-androgens-in-the-human-brain
#8
REVIEW
Tuong-Vi Nguyen
Neuroendocrine theories of brain development posit that androgens play a crucial role in sex-specific cortical growth, but little is known about the differential effects of testosterone and dehydroepiandrosterone (DHEA) on cortico-limbic development and cognition during adolescence. In this context, the NIH Study of Normal Brain Development, a longitudinal study of typically developing children and adolescents 4 to 24 years of age (n=433), offered a unique opportunity to examine the developmental effects of androgens on cortico-limbic maturation and cognition...
May 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28472898/the-relation-among-steroid-hormone-levels-lipid-profile-and-menopausal-symptom-severity
#9
Cihan Kaya, Hüseyin Cengiz, Ali Yeşil, Murat Ekin, Levent Yaşar
INTRODUCTION: Many postmenopausal women experience hot flashes, night sweats, non-specific emotional and psychological distresses. Our aim was to investigate the relation among steroid hormone levels, lipid profile and menopausal symptom severity using the menopause rating scale (MRS). METHODS: A cross-sectional study was performed at our outpatient clinic with natural postmenopausal women. A total of 444 women were included in this study. The basic characteristics of the study population, such as age, gravidity, parity, time to menopause onset and body mass index (BMI) were recorded...
May 4, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28468030/higher-dheas-levels-associated-with-long-term-practicing-of-tai-chi
#10
Hung-Min Lai, Mark Shui-Yu Liu, Ting-Ju Lin, Ying-Lan Tsai, Eileen Jea Chien
Tai Chi has many benefits for middle-aged/older individuals including improvements to muscle strength and various body lipid components. DHEAS and testosterone have anti-obesity/anti-aging characteristics and also improve libido, vitality and immunity levels. Thus, the aim of the present study was to investigate the differences between middle-aged Tai Chi practitioners (n = 17) and sedentary individuals (n = 17) in terms of leg strength, blood levels of cholesterol, triglyceride, HDL, as well as DHEAS, testosterone and cortisol...
April 30, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28456148/impact-of-emotional-disorders-on-semen-quality-in-men-treated-for-infertility
#11
Artur Wdowiak, Agnieszka Bień, Grażyna Iwanowicz-Palus, Marta Makara-Studzińska, Iwona Bojar
OBJECTIVE: Semen quality depends on factors such as lifestyle, environment, and hormone secretion. OBJECTIVE: The purpose of the study was to assess the correlation between emotional disorders and the secretion of selected hormones, and to assess the impact of these disorders on semen quality. METHODS: The study covered 60 fertile and 112 subfertile males. The sperm was obtained by masturbation, and examined directly after liquidation according to the 2010 criteria of the World Health Organization...
February 15, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28413941/psychobiological-protective-factors-modifying-the-association-between-age-and-sexual-health-in-men-findings-from-the-men-s-health-40-study
#12
Andreas Walther, Fiona Mahler, Rudolf Debelak, Ulrike Ehlert
Sexual health severely decreases with age. For males older than 40 years, erectile dysfunction (ED) is the most common sexual disorder. Although physical and psychological risk factors for ED have been identified, protective factors are yet to be determined. To date, no study has examined endocrine and psychosocial factors in parallel with regard to their modifying effect on the age-related increase in ED. Two hundred and seventy-one self-reporting healthy men aged between 40 and 75 years provided both psychometric data on sexual function and a set of potential psychosocial protective factors, and saliva samples for the analysis of steroid hormones and proinflammatory cytokines...
May 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28407517/social-status-strategy-in-early-adolescent-girls-testosterone-and-value-based-decision-making
#13
Stephanie L Cardoos, Ahna Ballonoff Suleiman, Megan Johnson, Wouter van den Bos, Stephen P Hinshaw, Ronald E Dahl
There has been strong interest, spanning several disciplines, in understanding adolescence as a developmental period of increased risk-taking behavior. Our goals focus on one line of investigation within this larger developmental risk framework. Specifically, we examined levels of pubertal hormones in girls in relation to their willingness to take greater financial risks to gain social status. To this end, we tested the hypothesis that higher levels of testosterone during the ages of pubertal maturation are associated with a greater willingness to sacrifice money for social admiration...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28401652/the-role-of-dehydroepiandrosterone-on-functional-innate-immune-responses-to-acute-stress
#14
Sean P Prall, Emilee E Larson, Michael P Muehlenbein
The androgen dehydroepiandrosterone (DHEA) responds to stress activation, exhibits anti-glucocorticoid properties, and modulates immunity in diverse ways, yet little is known of its role in acute stress responses. In this study, the effects of DHEA and its sulfate ester DHEA-S on human male immune function during exposure to an acute stressor is explored. Variation in DHEA, DHEA-S, testosterone, and cortisol, along with bacterial killing assays, was measured in response to a modified Trier Social Stress test in 27 young adult males...
April 11, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28389510/association-of-tissue-abiraterone-levels-and-slco-genotype-with-intraprostatic-steroids-and-pathologic-response-in-men-with-high-risk-localized-prostate-cancer
#15
Elahe A Mostaghel, Eunpi Cho, Ailin Zhang, Mohammad Alyamani, Arja Kaipainen, Sean Green, Brett Marck, Nima Sharifi, Jonathan L Wright, Roman Gulati, Lawrence D True, Massimo Loda, Alvin M Matsumoto, Daniel Tamae, Trevor N Penning, Steven P Balk, Philip W Kantoff, Peter S Nelson, Mary-Ellen Taplin, Bruce Montgomery
Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer (PCa) outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo SLCO-mediated transport and that SLCO gene variation may influence intracellular abiraterone levels and outcomes.<br /><br />Experimental Design: Steroid and abiraterone levels were measured by mass spectrometry in serum and tissue from 58 men with localized PCa in a clinical trial of LHRH agonist plus abiraterone acetate plus prednisone for 24 weeks prior to prostatectomy...
April 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28381542/androgens-are-differentially-associated-with-ovarian-cancer-subtypes-in-the-ovarian-cancer-cohort-consortium
#16
Jennifer Ose, Elizabeth M Poole, Helena Schock, Matti Lehtinen, Alan A Arslan, Anne Zeleniuch-Jacquotte, Kala Visvanathan, Kathy J Helzlsouer, Julie E Buring, I-Min Lee, Anne Tjønneland, Laure Dossus, Antonia Trichopoulou, Giovanna Masala, N Charlotte Onland-Moret, Elisabete Weiderpass, Eric J Duell, Annika Idahl, Ruth C Travis, Sabina Rinaldi, Melissa A Merritt, Britton Trabert, Nicolas Wentzensen, Shelley S Tworoger, Rudolf Kaaks, Renée T Fortner
Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on pre-diagnosis androgen concentrations and EOC risk has yielded inconclusive results, and analyses incorporating EOC subtypes are sparse. We conducted a pooled analysis of 7 nested case-control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens (testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)), sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i...
April 5, 2017: Cancer Research
https://www.readbyqxmd.com/read/28378209/bariatric-surgery-reduces-serum-anti-mullerian-hormone-levels-in-obese-women-with-and-without-polycystic-ovarian-syndrome
#17
Francesco Chiofalo, Cristina Ciuoli, Caterina Formichi, Federico Selmi, Raffaella Forleo, Ornella Neri, Giuseppe Vuolo, Patrizia Paffetti, Furio Pacini
PURPOSE: Obesity in fertile women has negative effect on fertility. Anti-mullerian hormone (AMH) represents a good index of fertility, and it is considered a marker of ovarian reserve and of polycystic ovarian syndrome (PCOS) gravity. Previous studies evaluated the relationship between obesity and AMH with contradictory results. The aim of the study was to investigate the relationship between obesity and AMH and the changes of AMH in obese women in reproductive age submitted to bariatric surgery...
April 5, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28376482/discordant-genotypic-sex-and-phenotype-variations-in-two-spanish-siblings-with-17%C3%AE-hydroxylase-17-20-lyase-deficiency-carrying-the-most-prevalent-mutated-cyp17a1-alleles-of-brazilian-patients
#18
Mónica Fernández-Cancio, Emilio García-García, Carmen González-Cejudo, María-Angeles Martínez-Maestre, Miguel-Angel Mangas-Cruz, Gil Guerra-Junior, Maricilda Pandi de Mello, Ivo J P Arnhold, Mirian Y Nishi, Berenice Bilharinho Mendonça, Elena García-Arumí, Laura Audí, Eduardo Tizzano, Antonio Carrascosa
17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia caused by mutations in CYP17A1. Two phenotypic female sisters, aged 17 and 15 years and with 46,XY and 46,XX karyotypes, respectively, presented with primary amenorrhea and absent secondary sexual characteristics. The elder sib also presented with high blood pressure. Both patients had elevated levels of ACTH, gonadotropins, progesterone, corticosterone, and deoxycorticosterone, and reduced levels of estradiol, testosterone, androstenedione, 17-OH-P, DHEA-S, cortisol, aldosterone, and renin activity...
April 4, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28373267/longitudinal-analyses-of-the-steroid-metabolome-in-obese-pcos-girls-with-weight-loss
#19
Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse, Paul-Martin Holterhus
OBJECTIVE: The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. DESIGN: This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13-16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI and change of weight status...
May 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28373106/umbilical-cord-blood-androgen-levels-in-girls-and-boys-assessed-by-gas-chromatography-tandem-mass-spectrometry
#20
Anna-Carin Lundell, Henrik Ryberg, Liesbeth Vandenput, Anna Rudin, Claes Ohlsson, Åsa Tivesten
Androgen exposure of the fetus during gestation plays an important role in human physiology and pathophysiology, but assessment of androgens, in particular dihydrotestosterone (DHT), in human umbilical cord blood is technically challenging. The aim of this study was to assess umbilical cord androgen levels, including DHT, at birth by a highly sensitive assay, and study their association with sex of the infant, sex-hormone-binding globulin (SHBG) levels, and gestational age at delivery. Swedish infants (27 girls, 26 boys) were recruited at maternity care clinics in Southern Sweden...
March 31, 2017: Journal of Steroid Biochemistry and Molecular Biology
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