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https://www.readbyqxmd.com/read/27319383/-the-benefits-of-carvedilol-therapy-in-the-treatment-of-patients-with-high-cardiovascular-risk
#1
REVIEW
Zsolt Fi, Veronika Szentes
Among the variety of cardiologic pharmacological therapy options, beta-blockers stand on a prominent position. There are several reasons for this. On one hand they have numerous indication rounds, even though professional guidelines have recently tended to de-emphasize them for treatments of hypertension without complication or comorbidity. However, in addition to hypertonic cases associated with cardiac complication, they play a fundamental role in treating heart failure and arrhythmia and the different clinical manifestations (stable angina pectoris, myocardial state) of ischemic heart disease...
June 26, 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27295183/effects-of-long-term-combined-treatment-with-somatostatin-analogues-and-pegvisomant-on-cardiac-structure-and-performance-in-acromegaly
#2
Renata S Auriemma, Ludovica F S Grasso, Mariano Galdiero, Maurizio Galderisi, Claudia Pivonello, Chiara Simeoli, Maria Cristina De Martino, Rosario Ferrigno, Mariarosaria Negri, Cristina de Angelis, Rosario Pivonello, Annamaria Colao
To date, no data are available on the effects of long-term combined treatment with somatostatin analogues (SA) and pegvisomant (PEG) on cardiovascular complications in acromegaly. The current study aimed at investigating the effects of long-term SA + PEG on cardiac structure and performance. Thirty-six patients (14 M, 22 F, aged 52.3 ± 10.2 years) entered this study. Weight, BMI, systolic (SBP) and diastolic (DBP) blood pressure, IGF-I, fasting glucose (FG), fasting insulin (FI), HOMA-IR, HbA1c, and lipids were evaluated at baseline (T0), after long-term (median 36 months) SA (T1), after 12 (T12) and 60 (T60) months of SA + PEG, and at last follow-up (LFU, median 78 months)...
June 13, 2016: Endocrine
https://www.readbyqxmd.com/read/27166209/frailty-trajectories-after-treatment-for-coronary-artery-disease-in-older-patients
#3
Elizabeth A Freiheit, David B Hogan, Scott B Patten, Hannah Wunsch, Todd Anderson, William A Ghali, Merril Knudtson, Colleen J Maxwell
BACKGROUND: Frailty is an independent risk factor for cardiovascular outcomes. However, its trajectory after coronary artery disease treatment is unknown. METHODS AND RESULTS: Three hundred seventy-four patients undergoing nonemergent cardiac catheterization followed by treatment (ie, 128 coronary artery bypass graft [CABG], 150 percutaneous coronary intervention [PCI], 96 medical therapy only) were observed for 30 months. A frailty index (FI) score was calculated at baseline (before initial treatment) and 6, 12, and 30 months after treatment...
May 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27164016/inhaled-anaesthetics-and-nitrous-oxide-complexities-overlooked-things-may-not-be-what-they-seem
#4
Jan Hendrickx, Philip Peyton, Rik Carette, Andre De Wolf
This review re-examines existing pharmacokinetic and pharmacodynamic concepts of inhaled anaesthetics. After showing where uptake is hidden in the classic FA/FI curve, it is argued that target-controlled delivery of inhaled agents warrants a different interpretation of the factors affecting this curve (cardiac output, ventilation and blood/gas partition coefficient). Blood/gas partition coefficients of modern agents may be less important clinically than generally assumed. The partial pressure cascade from delivered to inspired to end-expired is re-examined to better understand the effect of rebreathing during low-flow anaesthesia, including the possibility of developing a hypoxic inspired mixture despite existing machine standards...
September 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27162485/necrox-5-exerts-anti-inflammatory-and-anti-fibrotic-effects-via-modulation-of-the-tnf%C3%AE-dcn-tgf%C3%AE-1-smad2-pathway-in-hypoxia-reoxygenation-treated-rat-hearts
#5
Vu Thi Thu, Hyoung Kyu Kim, Le Thanh Long, To Thanh Thuy, Nguyen Quang Huy, Soon Ha Kim, Nari Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating infl ammation and fi brosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide (LPS)-treated H9C2 culture cells in the presence or absence of NecroX-5 (10 µmol/L) treatment as experimental models...
May 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27130278/discovery-of-novel-small-molecule-inhibitors-of-cardiac-hypertrophy-using-high-throughput-high-content-imaging
#6
Brian G Reid, Matthew S Stratton, Samantha Bowers, Maria A Cavasin, Kimberley M Demos-Davies, Isidro Susano, Timothy A McKinsey
Chronic cardiac hypertrophy is maladaptive and contributes to the pathogenesis of heart failure. The objective of this study was to identify small molecule inhibitors of pathological cardiomyocyte hypertrophy. High content screening was performed with primary neonatal rat ventricular myocytes (NRVMs) cultured on 96-well plates and treated with a library of 3241 distinct small molecules. Non-toxic hit compounds that blocked hypertrophy in response to phenylephrine (PE) and phorbol myristate acetate (PMA) were identified based on their ability to reduce cell size and inhibit expression of atrial natriuretic factor (ANF), which is a biomarker of pathological cardiac hypertrophy...
August 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27097511/-anesthesia-management-of-a-patient-with-pulmonary-atresia-intact-ventricular-septum-major-aortopulmonary-collateral-artery-and-tetralogy-of-fallot
#7
Takashi Hitosugi, Masanori Tsukamoto, Kentaro Ishii, Masanori Kadowaki, Shigeki Fujiwara, Takeshi Yokoyama
The patient was a 6-year-old girl with pulmonary atresia, intact ventricular septum and major aortopulmonary collateral artery with tetralogy of Fallot Her Sp(O2) was around 60% under room air, and she could not walk long. She underwent dental treatment under general anesthesia. Invasive monitoring using pulmonary artery catheter should have been avoided, since the risk of monitoring greatly exceeds that of the treatment. The patient entered the operating room with her mother, and anesthesia was induced with intravenous midazolam, propofol and vecuronium...
March 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/27058608/effects-of-phototherapy-on-coronary-blood-flow-in-healthy-neonates-a-pilot-study
#8
Liron Borenstein-Levin, Dawod Sharif, Annat Amshalom, Arieh Riskin, Miri Hemo, Amen Khalil, David Bader, Amir Kugelman
BACKGROUND: Phototherapy has been reported to alter blood flow to various tissues. We hypothesized that during phototherapy the coronary blood flow will decrease because of a 'steal effect' to the periphery. OBJECTIVES: To evaluate the effects of phototherapy on coronary blood flow in healthy, jaundiced, term neonates. METHODS: Flow velocity [peak diastolic velocity (Vd)] and flow measures [diastolic time velocity integral (TVId) and flow index (FI)] in the left main (LM) and left anterior descending (LAD) coronary arteries were prospectively studied with 2D/pulsed Doppler ultrasound before, during and after phototherapy in 19 healthy term, jaundiced neonates (study group) and in matched nonjaundiced controls (25 neonates)...
2016: Neonatology
https://www.readbyqxmd.com/read/26096116/prevalence-of-eight-putative-periodontal-pathogens-in-atherosclerotic-plaque-of-coronary-artery-disease-patients-and-comparing-them-with-noncardiac-subjects-a-case-control-study
#9
Jaideep Mahendra, Little Mahendra, Aishwarya Nagarajan, Kurien Mathew
BACKGROUND: The study was aimed to assess the prevalence of periodontal pathogens namely Tannerella forsythia (T.f), Campylobacter rectus (C.r), Eikenella corrodens (E.c), Porphyromonas gingivalis (P.g), Treponema denticola (T.d), Prevotella nigrescens (P.n) ,Aggregatibacter actinomycetemcomitans (A.a), P.g (fi mA gene) and Prevotella intermedia (P.i), in the subgingival and the atheromatous plaque of patients with coronary artery disease (CAD), and comparing them with the noncardiac subjects thereby indicating the role of periodontal pathogenic bacteria in the progression of atherosclerosis in south Indian population...
March 2015: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/25486976/the-impact-of-frailty-on-postoperative-delirium-in-cardiac-surgery-patients
#10
Patrick Jung, Michael Ashley Pereira, Brett Hiebert, Xiaiwei Song, Kenneth Rockwood, Navdeep Tangri, Rakesh C Arora
OBJECTIVE: To determine if adding frailty measures to the EuroSCORE II improves model performance in predicting postoperative delirium. METHODS: In a prospective observational study in elective cardiac surgery patients, frailty was defined using the Modified Fried Criteria (MFC), the Short Physical Performance Battery (SPPB) and a 35-item Frailty Index (FI). The primary outcome was postoperative delirium, assessed using the Confusion Assessment Method (CAM). RESULTS: Seventy-two (54...
March 2015: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24920308/superiority-of-frailty-over-age-in-predicting-outcomes-among-geriatric-trauma-patients-a-prospective-analysis
#11
Bellal Joseph, Viraj Pandit, Bardiya Zangbar, Narong Kulvatunyou, Ammar Hashmi, Donald J Green, Terence O'Keeffe, Andrew Tang, Gary Vercruysse, Mindy J Fain, Randall S Friese, Peter Rhee
IMPORTANCE: The Frailty Index (FI) is a known predictor of adverse outcomes in geriatric patients. The usefulness of the FI as an outcome measure in geriatric trauma patients is unknown. OBJECTIVE: To assess the usefulness of the FI as an effective assessment tool in predicting adverse outcomes in geriatric trauma patients. DESIGN, SETTING, AND PARTICIPANTS: A 2-year (June 2011 to February 2013) prospective cohort study at a level I trauma center at the University of Arizona...
August 2014: JAMA Surgery
https://www.readbyqxmd.com/read/24760512/the-isovolumic-relaxation-to-early-rapid-filling-relation-kinematic-model-based-prediction-with-in-vivo-validation
#12
Sina Mossahebi, Sándor J Kovács
Abstract Although catheterization is the gold standard, Doppler echocardiography is the preferred diastolic function (DF) characterization method. The physiology of diastole requires continuity of left ventricular pressure (LVP)-generating forces before and after mitral valve opening (MVO). Correlations between isovolumic relaxation (IVR) indexes such as tau (time-constant of IVR) and noninvasive, Doppler E-wave-derived metrics, such as peak A-V gradient or deceleration time (DT), have been established. However, what has been missing is the model-predicted causal link that connects isovolumic relaxation (IVR) to suction-initiated filling (E-wave)...
2014: Physiological Reports
https://www.readbyqxmd.com/read/24748275/stroke-risk-factors-in-an-incident-population-in-urban-and-rural-tanzania-a-prospective-community-based-case-control-study
#13
(no author information available yet)
BACKGROUND: The burden of stroke on health systems in low-income and middle-income countries is increasing. However, high-quality data for modifiable stroke risk factors in sub-Saharan Africa are scarce, with no community based, case-control studies previously published. We aimed to identify risk factors for stroke in an incident population from rural and urban Tanzania. METHODS: Stroke cases from urban Dar-es-Salaam and the rural Hai district were recruited in a wider study of stroke incidence between June 15, 2003, and June 15, 2006...
November 2013: Lancet Global Health
https://www.readbyqxmd.com/read/24673382/patterns-of-coronary-artery-ectasia-and-short-term-outcome-in-acute-myocardial-infarction
#14
Usama Boles, Ying Zhao, Roby Rakhit, Man Fi Shiu, Alexandros Papachristidis, Santosh David, Sudheer Koganti, Timothy Gilbert, Michael Y Henein
OBJECTIVE: To assess the relationship between hematological inflammatory signs, cardiovascular risk (CV) factors and prognosis in patients presenting with acute myocardial infarction (AMI) and coronary artery ectasia (CAE). DESIGN: We investigated 3321 AMI patients who required urgent primary percutaneous intervention in two centres in the United Kingdom between January 2009 and August 2012. Thirty patients with CAE were compared with 60 age- and gender-matched controls...
June 2014: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/24338541/is-abnormal-myocardial-repolarization-associated-with-the-occurrence-of-malignant-tachyarrhythmias-in-takotsubo-cardiomyopathy
#15
Florian Streitner, Karsten Hamm, Ilan S Wittstein, Adrian Baranchuk, Yoshihiro J Akashi, Holger M Nef, Laurent Bonello, Christian Wolpert, Martin Borggrefe, Dariusch Haghi
BACKGROUND: Abnormalities of cardiac repolarization are a hallmark of Takotsubo cardiomyopathy (TC), but their association with the occurrence of syncope and ventricular tachyarrhythmias is unknown. This study sought to assess the relationship between myocardial repolarization and malignant tachyarrhythmias in TC. METHODS: Clinical data and electrocardiographic repolarization parameters of 28 patients with TC and ventricular tachyarrhythmias (n = 26) or syncope (n = 2) were compared to data from 20 randomly selected patients with TC but without ventricular tachyarrhythmias or syncope...
2013: Cardiology Journal
https://www.readbyqxmd.com/read/24043537/-carcinoma-of-the-pararenal-gland-infiltrating-the-surrounding-tissue-and-involving-the-inferior-vena-cava
#16
J Dillner, F Meyer, H Lippert, C Huth, S Klose, A Roessner, Z Halloul
UNLABELLED: ▼HISTORY AND ADMISSION FI NDINGS: A 61-year-old woman presented with a 2-month-history of progressive deterioration, increasing exertional dyspnoea and pain in the right upper abdomen (past medical history: bronchial asthma and hypertension). The physical examination showed mild generalized weakness, tenderness in the right upper abdomen, and ascites. INVESTIGATIONS: Laboratory studies did not reveal any hormonal abnormalities. A CT angiogram revealed a mass of the right adrenal gland with distinct invasion into the inferior vena cava, and tumour thrombosis that extended proximally into the right atrium...
September 2013: Aktuelle Urologie
https://www.readbyqxmd.com/read/23931245/comparative-study-related-to-cardiovascular-safety-between-bupivacaine-s75-r25-and-ropivacaine-in-brachial-plexus-block
#17
RANDOMIZED CONTROLLED TRIAL
Adilson Hamaji, Marcelo Rosa de Rezende, Rames Mattar, Joaquim Edson Vieira, José Otávio Costa Auler
BACKGROUND AND OBJECTIVES: Bupivacaine is a fi rst choice for regional anesthesia considering its effectiveness, long duration and less motor blockade. Bupivacaine (S75-R25) is a mixture of optical isomers containing 75% levobupivacaine (S-) and 25% dextrobupivacaine (R+) created by a Brazilian pharmaceutical company. This investigation compared cardiac safety and efficacy of bupivacaine S75-R25 with vasoconstrictor and ropivacaine for brachial plexus blockade. METHODS: Patients were randomized to receive brachial plexus anesthesia with either bupivacaine S75-R25 with epinephrine 1:200,000 (bupi) or ropivacaine (ropi), both at 0...
July 2013: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/23901875/hemojuvelin-modulates-iron-stress-during-acute-kidney-injury-improved-by-furin-inhibitor
#18
Guang-Huar Young, Tao-Min Huang, Che-Hsiung Wu, Chun-Fu Lai, Chun-Cheng Hou, Kang-Yung Peng, Chan-Jung Liang, Shuei-Liong Lin, Shih-Chung Chang, Pi-Ru Tsai, Kwan-Dun Wu, Vin-Cent Wu, Wen-Je Ko
AIMS: Free iron plays an important role in the pathogenesis of acute kidney injury (AKI) via the formation of hydroxyl radicals. Systemic iron homeostasis is controlled by the hemojuvelin-hepcidin-ferroportin axis in the liver, but less is known about this role in AKI. RESULTS: By proteomics, we identified a 42 kDa soluble hemojuvelin (sHJV), processed by furin protease from membrane-bound hemojuvelin (mHJV), in the urine during AKI after cardiac surgery. Biopsies from human and mouse specimens with AKI confirm that HJV is extensively increased in renal tubules...
March 10, 2014: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/23704088/rhoa-mediates-defective-stem-cell-function-and-heterotopic-ossification-in-dystrophic-muscle-of-mice
#19
Xiaodong Mu, Arvydas Usas, Ying Tang, Aiping Lu, Bing Wang, Kurt Weiss, Johnny Huard
Heterotopic ossification (HO) and fatty infiltration (FI) often occur in diseased skeletal muscle and have been previously described in various animal models of Duchenne muscular dystrophy (DMD); however, the pathological mechanisms remain largely unknown. Dystrophin-deficient mdx mice and dystrophin/utrophin double-knockout (dKO) mice are mouse models of DMD; however, mdx mice display a strong muscle regeneration capacity, while dKO mice exhibit a much more severe phenotype, which is similar to patients with DMD...
September 2013: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/23691953/combined-dominant-frequency-and-complex-fractionated-atrial-electrogram-ablation-after-circumferential-pulmonary-vein-isolation-of-atrial-fibrillation
#20
Koji Kumagai, Tamotsu Sakamoto, Keijiro Nakamura, Suguru Nishiuchi, Mamoru Hayano, Tatsuya Hayashi, Takehito Sasaki, Kazutaka Aonuma, Shigeru Oshima
INTRODUCTION: Atrial substrates with high-dominant frequency (DF) and complex fractionated atrial electrogram (CFAE) sites have sources maintaining atrial fibrillation (AF) and are potential AF ablation targets. This study aimed to evaluate an approach of circumferential pulmonary vein isolation (PVI) followed by a DF and CFAE site ablation. METHODS AND RESULTS: Fifty consecutive AF patients (23 paroxysmal, 9 persistent, and 18 longstanding persistent) underwent ablation, using NavX...
September 2013: Journal of Cardiovascular Electrophysiology
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