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Chronic sinusitis

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https://www.readbyqxmd.com/read/29138409/predicting-the-origin-of-ventricular-arrhythmia-using-acoustic-cardiography
#1
Chin-Yu Lin, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Ta-Chuan Tuan, Jo-Nan Liao, Yao-Ting Chang, Abigail Louise D Te, Shinya Yamada, Hao-Min Cheng, Shih-Hsien Sung, Ling Kuo, Hsing-Yuan Li, Ting-Yung Chang, Hoang Quang Minh, Simon Salim, Ting-Chung Huang, Shih-Ann Chen
This study aimed to examine the relationship between measurements related to heart sounds and the origin of ventricular arrhythmia. We retrospectively evaluated 45 patients undergoing catheter ablation with contemporaneous digital acoustic cardiography of the first heart sound (S1) and the second heart sound (S2). The patients with baseline wide QRS morphology (>120 ms or aberrant conduction), heart failure, valvular heart disease, chronic pulmonary disease, and obesity were excluded. Ventricular arrhythmias from the left ventricle had an increased S1 complexity score and S1 duration in comparison to adjacent sinus beats...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133225/longitudinal-evaluation-of-chronic-rhinosinusitis-symptoms-in-a-population-based-sample
#2
Agnes S Sundaresan, Annemarie G Hirsch, Amanda J Young, Jonathan Pollak, Bruce K Tan, Robert P Schleimer, Robert C Kern, Thomas L Kennedy, J Scott Greene, Walter F Stewart, Karen Bandeen-Roche, Brian S Schwartz
BACKGROUND: Chronic rhinosinusitis (CRS) is a prevalent and disabling condition of the nose and sinuses. The natural history of CRS symptoms in a general population sample has not been previously studied. OBJECTIVE: In a general population-based sample from Pennsylvania, we used 2 questionnaires mailed 6 months apart to estimate the prevalence of, and identify predictors for, stability or change in symptoms over time. METHODS: We mailed the baseline and 6-month follow-up questionnaires to 23,700 primary care patients and 7,801 baseline responders, respectively...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29122083/biocompatibility-and-pharmacokinetics-of-fluticasone-eluting-sinus-implant-in-a-rabbit-model
#3
Vishal S Patel, Evan Walgama, Alkis Psaltis, Francois Lavigne, Steven D Pletcher, Peter H Hwang
BACKGROUND: A novel, bioabsorbable, fibrinogen-based implant has been developed as a mucosal dressing after endoscopic sinus surgery (ESS). This implant can be formulated with fluticasone propionate (FP) for local elution of corticosteroid to reduce postoperative inflammation and promote mucosal healing. OBJECTIVE: This study investigated the biocompatibility and pharmacokinetics of the implant in a rabbit model. METHODS: Implants with and without FP were placed on both intact and demucosalized maxillary sinuses of 33 New Zealand White rabbits...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29122081/gender-specific-differences-in-serum-immunoglobulin-e-levels-and-prevalence-of-fungus-in-sinonasal-tissue-noted-in-patients-with-chronic-rhinosinusitis-who-underwent-endoscopic-sinus-surgery
#4
Antoine Azar, Matthew A Rank, Matthew A Zarka, Yu-Hui Chang, Devyani Lal
BACKGROUND: We previously presented that women with chronic rhinosinusitis (CRS) who elected endoscopic sinus surgery (ESS) have a higher symptom burden than men. Causes of these gender-based differences warranted further study. OBJECTIVES: To study gender differences in another cohort of adult patients with CRS who underwent ESS and to compare key histopathologic and serologic features Methods: Patients with CRS who underwent ESS (from 2011 to 2014) with structured histopathology reports on surgical samples were studied...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29122079/sinonasal-t-cell-expression-of-cytotoxic-mediators-granzyme-b-and-perforin-is-reduced-in-patients-with-chronic-rhinosinusitis
#5
Sarah E Smith, Rodney J Schlosser, James R Yawn, Jose L Mattos, Zachary M Soler, Jennifer K Mulligan
BACKGROUND: CD8+ T cells and natural killer (NK) cells are cytotoxic cells that use granzyme B (GrB) and perforin. Defective cytotoxic function is known to play a role in dysregulated immune response as seen in chronic sinusitis, also referred to as chronic rhinosinusitis (CRS). However, to our knowledge, in the United States, neither GrB or perforin expression has been reported in patients with CRS. OBJECTIVE: The aim of this study was to investigate sinonasal cytotoxic cells, their mediators, and cell-specific distribution of these mediators in patients with CRS with nasal polyp (CRSwNP) and in patients with CRS without nasal polyp (CRSsNP)...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29121272/chronic-cigarette-smoking-associates-directly-and-indirectly-with-self-reported-olfactory-alterations-analysis-of-the-2011-2014-national-health-and-nutrition-examination-survey-nhanes
#6
Sarah-Grace Glennon, Tania Huedo-Medina, Shristi Rawal, Howard J Hoffman, Mark D Litt, Valerie B Duffy
Introduction: Population-based studies show inconsistent effects of cigarette smoking on olfactory function. We aimed to identify direct and indirect associations between measures of smoking exposure/nicotine dependence and altered olfaction in a nationally-representative sample of adults. Methods: NHANES 2011-2014 (n=7,418) participants (mean age=57.8±12.2 years) self-reported olfaction and related health and demographic risks. Affirmative answers to three questions defined altered olfaction (olfactory problems in past year; worse ability since age 25; phantom smells)...
November 7, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29119077/osteomyelitis-of-the-pelvic-bones-a-multidisciplinary-approach-to-treatment
#7
Maria Dudareva, Jamie Ferguson, Nicholas Riley, David Stubbs, Bridget Atkins, Martin McNally
Background and Purpose: A case series review of chronic pelvic osteomyelitis treated with combined medical and surgical treatment by a multidisciplinary team. Methods: All patients treated with surgical excision of pelvic osteomyelitis at our tertiary referral centre between 2002 and 2014 were included. All received combined care from a clinical microbiologist, an orthopaedic surgeon and a plastic surgeon. The rate of recurrent infection, wound healing problems and post-operative mortality was determined in all...
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/29118492/association-of-ocular-findings-and-outcome-in-cerebral-venous-thrombosis
#8
Samira Yadegari, Alireza Keshtkar Jafari, Elham Ashrafi
BACKGROUND: Cerebral venous thrombosis (CVT) is a potentially life-threatening underdiagnosed disease. Headache is a common but nonspecific finding in CVT. Other features such as ocular finding can assist to correct diagnosis, but their frequency in CVT has not been previously evaluated. The aim of this study is to evaluate the ocular symptoms and signs in CVT and their association with outcome. METHODS: The demographic, clinical, laboratory, radiological, and outcome data were collected and analyzed from patients referred to a tertiary hospital during 6 years...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29115761/diagnosis-and-management-of-children-with-primary-ciliary-dyskinesia
#9
Amanda Harris
Primary ciliary dyskinesia (PCD) is a rare, genetic disorder of the motile cilia characterised by chronic lung disease, nasal and sinus disease, chronic ear infections with glue ear leading to possible hearing impairment, and subfertility. Half of patients have organ laterality defects. Despite symptoms being present from birth, PCD remains underdiagnosed. Early diagnosis and symptom management may reduce morbidity, improve quality of life and ensure children are adequately supported to meet their full potential...
September 11, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29115522/role-of-epigenetics-in-the-pathogenesis-of-chronic-rhinosinusitis-with-nasal-polyps
#10
Jong-Yeup Kim, Dong-Kyu Kim, Myeong Sang Yu, Min-Ji Cha, Seong-Lan Yu, Jaeku Kang
Chronic rhinosinusitis (CRS) is a highly prevalent disease characterized by mucosal inflammation of the nose and paranasal sinuses. CRS can be divided into two main categories, CRS with nasal polyps (NPs; CRSwNP) and CRS without NPs (CRSsNP). Although the pathophysiology of CRS remains unclear, DNA methylation has been implicated in the etiology of CRSwNP. The aim of the present study was to elucidate whether DNA methylation of specific genes is involved in the development of NPs. In total, 18 individuals were included in the present study, and were divided into three groups: CRSwNP (n=7), CRSsNP (n=7) and healthy controls (n=4)...
November 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115519/pten-promotes-apoptosis-of-h2o2%C3%A2-injured-rat-nasal-epithelial-cells-through-pi3k-akt-and-other-pathways
#11
Minghui Jia, Xiaoyun Chen, Jili Liu, Jun Chen
Chronic rhinosinusitis (CRS) is a form of chronic inflammation of the nasal cavity and paranasal sinus with multi‑causal pathogenesis, including oxidative stress. Several lines of evidence have demonstrated that the phosphatase and tensin homolog gene (PTEN) can inhibit the activation of phosphoinositide 3‑kinase (PI3K) to affect phosphorylation of Akt. Importantly, the PI3K/PTEN/Akt signaling pathway is associated with various types of tumors, chronic inflammatory diseases, and autoimmune disease through its regulation of cell growth, apoptosis, proliferation, and metabolism...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114894/lack-of-long-term-add-on-effect-by-montelukast-in-postoperative-chronic-rhinosinusitis-patients-with-nasal-polyps
#12
Laura Van Gerven, Cristobal Langdon, Arturo Cordero, Sara Cardelús, Joaquim Mullol, Isam Alobid
OBJECTIVES/HYPOTHESIS: Eosinophils and mast cells are among the key cells in inflammatory diseases like chronic rhinosinusitis (CRS) and asthma. Leukotriene antagonists have proven to be effective in the treatment of asthma, but data about their efficacy in CRS are scarce, whereas data on montelukast as an add-on treatment to intranasal corticosteroids (INCS) in a postoperative setting are completely lacking. STUDY DESIGN: Prospective, randomized, open-label trial...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29114315/intracranial-hypotension-associated-cerebral-swelling-following-cranioplasty-report-of-two-cases
#13
Masashi Nomura, Takahiro Ota, Mitsugu Ishizawa, Shinsuke Yoshida, Takayuki Hara
Cranioplasty is a comparatively simple neurosurgical procedure, and fatal complications are rare. This report describes two cases of critical brain swelling after otherwise uneventful cranioplasty. Both cases had subarachnoid hemorrhage and extremely similar clinical courses. They underwent decompressive craniotomy and clipping in the acute phase and had cranioplasty in the chronic phase, resulting in serious cerebral swelling and death. Deep venous sinus thrombosis was revealed in the autopsy for one case...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29114305/frontal-mucocele-mimicking-a-frontal-subcutaneous-tumor
#14
Ellath Valappil Bijith, Shaju Mathew, Krishnaswamy Mahadevan
Mucoceles are chronic, expanding, mucosa lined pathology of the paranasal sinuses. Frontal mucocele usually presents with the visual complaints such as diplopia, diminution of vision, visual field defect, ptosis, orbital swelling, retro-orbital pain, displacement of eye globe, and proptosis. Very rarely, it can be present as a subcutaneous swelling. This article presents a 58-year-old male patient presenting with an asymptomatic periorbital swelling and a painless forehead mass of 3 years duration. There was a partial ptosis, and an elongated, soft, subcutaneous mass over the forehead...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29110635/a-modified-endoscopic-submucosal-dissection-for-a-superficial-hypopharyngeal-cancer-a-case-report-and-technical-discussion
#15
Lianjun Di, Kuang-I Fu, Rui Xie, Xinglong Wu, Youfeng Li, Huichao Wu, Biguang Tuo
BACKGROUND: Adequate working space and a clear view for the dissected lesion are crucial for endoscopic submucosal dissection (ESD). Pharyngeal ESD requires that an otorhinolaryngologist creates working space by lifting the larynx with a curved laryngoscope. However, many countries do not have this kind of curved laryngoscope, and the devices could interfere with endoscope because of the narrow space of the pharynx. To overcome these issues, we used a transparent hood (Elastic Touch, slit and hole type, M (long), Top company, Tokyo Japan) instead of the curved laryngoscope to create adequate working space by pushing the larynx, and pharyngeal ESD could be done by gastroenterologists...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29106876/early-signs-and-symptoms-of-intracranial-complications-of-otitis-media-in-pediatric-and-adult-patients-a-different-presentation
#16
N A Van der Poel, E van Spronsen, D A Dietz de Loos, F A Ebbens
OBJECTIVES: The aim of this study was to review the clinical presentation and early signs and symptoms of otogenic intracranial complications (OIC) in children and adults. METHODS: retrospective chart review. The medical records of all children and adults admitted in our center with OIC during the period 2008-2017 were reviewed. Data concerning clinical presentation, treatment and outcomes were reviewed and analyzed. RESULTS: We included 47 patients with OIC: 21 children (range 1-13 years) and 26 adults (range 22-71 years)...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29106860/evaluating-the-sinus-and-nasal-quality-of-life-survey-in-the-pediatric-cystic-fibrosis-patient-population
#17
Deborah X Xie, Jeffanie Wu, Katherine Kelly, Rebekah F Brown, Chevis Shannon, Frank W Virgin
INTRODUCTION: The Sinus and Nasal Quality of Life Survey (SN-5) is a validated quality of life (QOL) questionnaire for chronic rhinosinusitis in patients age 2-12. Its utility in the cystic fibrosis (CF) has been studied, but not yet validated. The purpose of this study is to determine the effectiveness of the SN-5 for evaluation of sinonasal symptoms in the pediatric CF population. METHODS: This retrospective study analyzed SN-5 surveys completed between 2012 and 2015 by pediatric CF patients and caregivers...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29103993/role-of-twik-related-potassium-channel-1-trek-1-in-chronic-rhinosinusitis
#18
Ha Kyun Kim, Jae Hyeong Kim, Hyun Jung Kim, Tae Hoon Kim, Sang Hag Lee
TREK-1 constitutively expressed in normal sinus mucosa is down-regulated in inflammatory sinus mucosa where it may be involved in defective epithelial and endothelial barrier integrity. These results suggest that TREK-1 activating compounds may be used therapeutically to maintain the epithelial and endothelial barrier integrity in chronic rhinosinusitis.
November 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29103074/diagnostic-accuracy-of-synovial-fluid-blood-markers-and-microbiological-testing-in-chronic-knee-prosthetic-infections
#19
Giovanni Balato, Vincenzo Franceschini, Tiziana Ascione, Alfredo Lamberti, Fiamma Balboni, Andrea Baldini
INTRODUCTION: This retrospective study was undertaken to define cut-off values for synovial fluid (SF) leukocyte count and neutrophil percentage for differentiating aseptic failure and periprosthetic joint infection (PJI) and to evaluate the diagnostic accuracy of blood inflammatory markers, and microbiological testing according to the criteria proposed by the International Consensus Meeting (ICM) of Philadelphia. METHODS: All patients who underwent revision total knee arthroplasty from January 2010 to July 2015 were included: we identified and classified 31 PJIs and 136 aseptic joints...
November 4, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29101992/acr-appropriateness-criteria-%C3%A2-sinonasal-disease
#20
Claudia F E Kirsch, Julie Bykowski, Joseph M Aulino, Kevin L Berger, Asim F Choudhri, David B Conley, Michael D Luttrull, Diego Nunez, Lubdha M Shah, Aseem Sharma, Vilaas S Shetty, Rathan M Subramaniam, Sophia C Symko, Rebecca S Cornelius
Imaging of sinonasal pathology may occur for assessment of rhinosinusitis or mass lesions. Rhinosinusitis is prevalent in up to 16% of the US population with annual economic burdens estimated at 22 billion dollars. Rhinosinusitis is characterized as acute or chronic based on symptom duration; if four or more episodes occur annually, the term recurrent acute rhinosinusitis (RARS) is used. In acute uncomplicated rhinosinusitis when inflammatory change remains in the paranasal sinuses and nasal cavity, imaging may not be required...
November 2017: Journal of the American College of Radiology: JACR
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