John Tchen, Quentin Simon, Léa Chapart, Morgane K Thaminy, Shamila Vibhushan, Loredana Saveanu, Yasmine Lamri, Fanny Saidoune, Emeline Pacreau, Christophe Pellefigues, Julie Bex-Coudrat, Hajime Karasuyama, Kensuke Miyake, Juan Hidalgo, Padraic G Fallon, Thomas Papo, Ulrich Blank, Marc Benhamou, Guillaume Hanouna, Karim Sacre, Eric Daugas, Nicolas Charles
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary lymphoid organs (SLO), amplify autoantibody production and disease progression through mechanisms that remain to be defined. Here, we provide evidence for a direct functional relationship between TFH cells and basophils during lupus pathogenesis, both in humans and mice...
April 22, 2024: Nature Communications