keyword
https://read.qxmd.com/read/38547092/oxidative-study-a-pilot-prospective-observational-cohort-study-protocol-examining-the-influence-of-peri-reperfusion-hyperoxemia-and-immune-dysregulation-on-early-allograft-dysfunction-after-orthotopic-liver-transplantation
#1
JOURNAL ARTICLE
Elizabeth A Wilson, Anna Woodbury, Kirsten M Williams, Craig M Coopersmith
Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia reperfusion injury (IRI), a phenomenon characterized by oxygen scarcity followed by paradoxical oxidative stress and inflammation. With the expanded use of marginal allografts more susceptible to IRI, the incidence of EAD may be increasing. This necessitates an in-depth understanding of the innate molecular mechanisms underlying EAD and interventions to mitigate its impact...
2024: PloS One
https://read.qxmd.com/read/38546874/acetylation-of-c-myc-at-lysine-148-protects-neurons-after-ischemia
#2
JOURNAL ARTICLE
V V Guzenko, S S Bachurin, V A Dzreyan, A M Khaitin, Y N Kalyuzhnaya, S V Demyanenko
This study focuses on understanding the role of c-Myc, a cancer-associated transcription factor, in the penumbra following ischemic stroke. While its involvement in cell death and survival is recognized, its post-translational modifications, particularly acetylation, remain understudied in ischemia models. Investigating these modifications could have significant clinical implications for controlling c-Myc activity in the central nervous system. Although previous studies on c-Myc acetylation have been limited to non-neuronal cells, our research examines its expression in perifocal cells during stroke recovery to explore regulatory mechanisms via acetylation...
March 28, 2024: Neuromolecular Medicine
https://read.qxmd.com/read/38546307/the-other-aortic-syndrome-intramural-hematoma-and-neurological-deficit-case-report
#3
JOURNAL ARTICLE
Laura E Walker, Chris Marcellino, Bhargavi Gali
INTRODUCTION: Acute thoracic aortic syndromes are among the most concerning presentations in emergency medicine and are associated with significant morbidity and mortality. Thoracic aortic dissection is most common, followed by penetrating aortic ulcer and, least commonly, intramural hematoma. CASE REPORT: A 67-year-old woman presented to the emergency department with chest and back pain, and sudden onset of paraparesis. Aortic intramural hematoma was diagnosed, and she underwent spinal drain placement with blood pressure control to optimize spinal cord perfusion...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546305/peripartum-cardiac-arrest-with-terminal-qrs-distortion-a-case-report
#4
JOURNAL ARTICLE
Timothy D Kelly, Nicholas E Harrison
INTRODUCTION: Peripartum cardiac arrest is increasing in incidence. While pulmonary embolism (PE) remains an important cause of peripartum morbidity and mortality, other cardiovascular emergencies such as myocardial infarction (MI) are now the leading cause of pregnancy-related death. Emergency physicians (EP) need to be well versed in subtle electrocardiographic (ECG) signs of coronary ischemia to better care for peripartum patients in cardiac arrest. CASE REPORT: A 38-year-old gravida 2 parity1 female three days post-partum presented in cardiac arrest...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546131/acute-and-mid-term-results-of-atherectomy-in-femoropopliteal-lesions
#5
JOURNAL ARTICLE
Elias Noory, Tanja Böhme, Yannick Steinhauser, Jonas Salm, Ulrich Beschorner, Andrew de Forest, Roaa Bollenbacher, Dirk Westermann, Thomas Zeller
BACKGROUND: The femoropopliteal arteries are commonly affected by atherosclerotic lesions. The use of atherectomy may increase the benefit of definitive therapy, such as drug-coated balloon (DCB) angioplasty. PURPOSE: To analyze the 2-year safety and efficacy of atherectomy in general and stratified by directional atherectomy (DA) and front-cutting atherectomy (FA) for the treatment of atherosclerotic lesions of the femoropopliteal arteries. METHODS: A retrospective analysis was performed including patients who underwent vessel preparation with atherectomy...
March 28, 2024: Journal of Endovascular Therapy
https://read.qxmd.com/read/38546011/cocaine-gut-a-rare-case-of-cocaine-induced-esophageal-gastric-and-small-bowel-necrosis
#6
JOURNAL ARTICLE
Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum
Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38545792/preconditioning-exercise-inhibits-neuron-ferroptosis-and-ameliorates-brain-ischemia-damage-by-skeletal-muscle-derived-exosomes-via-regulating-mir-484-acsl4-axis
#7
JOURNAL ARTICLE
Mudan Huang, Shimei Cheng, Ziwen Li, Jinshuo Chen, Chuangjia Wang, Jun Li, Haiqing Zheng
AIMS: Although there is evidence that stroke patients who exercise regularly before stroke have a better prognosis than those who do not exercise, the detailed mechanism remains unclear. Moreover, neuronal death plays a central role in neurological dysfunction caused by ischemic stroke. Thus, we investigated whether exercise could reduce stroke-induced neuronal death and its associated mediators in the current study. RESULTS: Ferroptosis was the most dominant form of programmed cell death in neurons...
March 28, 2024: Antioxidants & Redox Signaling
https://read.qxmd.com/read/38545343/risk-factors-prevention-and-therapy-of-intraluminal-stent-thrombosis-in-frozen-elephant-trunk-prostheses-what-we-know-so-far
#8
REVIEW
Florian Helms, Bastian Schmack, Alexander Weymann, Reza Poyanmehr, Andreas Martens, Jawad Salman, Alina Zubarevich, Jan D Schmitto, Arjang Ruhparwar, Aron-Frederik Popov
Intraluminal thrombus formation (ILT) is a recently discovered and highly clinically relevant complication after frozen elephant trunk implantation in cardiovascular surgery. In this phenomenon, a thrombus forms within the lumen of the stent graft component of the frozen elephant trunk prosthesis and puts the patient at risk for downstream embolization with visceral or lower limb ischemia. Incidence of ILT reported in the currently available studies ranges from 6% to 17% of patients after frozen elephant trunk implantation...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38545251/rate-pressure-product-is-a-novel-predictor-for-short-and-long-term-mortality-in-patients-with-acute-coronary-syndrome-undergoing-primary-pci-immediate-invasive-strategy
#9
JOURNAL ARTICLE
Jian Zhou, Ya-Jie Li, Xiao-Dong Zhou, Li-Juan Wang
BACKGROUND: Rate-pressure product (RPP) calculated by multiplying heart rate by systolic blood pressure, is a convenient indicator closely associated with cardiac work or myocardial oxygen consumption. It has been reported to relate strongly to important indices of cardiovascular risk in patients with myocardial ischemia. However, its relationship with short- and long-term mortality in patients with acute coronary syndrome (ACS) undergoing primary PCI/immediate invasive strategy has not been defined...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38545102/immune-cell-expression-patterns-of-cd39-cd73-ectonucleotidases-in-rodent-models-of-cardiac-arrest-and-resuscitation
#10
JOURNAL ARTICLE
Tomoaki Aoki, Vanessa Wong, Tai Yin, Eriko Nakamura, Yusuke Endo, Kei Hayashida, Simon C Robson, Harshal Nandurkar, Betty Diamond, Sun Jung Kim, Atsushi Murao, Ping Wang, Lance B Becker, Koichiro Shinozaki
BACKGROUND: Cardiac arrest (CA) is a significant public health concern. There is the high imminent mortality and survival in those who are resuscitated is substantively compromised by the post-CA syndrome (PCAS), characterized by multiorgan ischemia-reperfusion injury (IRI). The inflammatory response in PCAS is complex and involves various immune cell types, including lymphocytes and myeloid cells that have been shown to exacerbate organ IRI, such as myocardial infarction. Purinergic signaling, as regulated by CD39 and CD73, has emerged as centrally important in the context of organ-specific IRI...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544959/alcohol-extract-of-rubia-yunnanensis-metabolic-alterations-and-preventive-effects-against-ogd-r%C3%A2-induced-oxidative-damage-in-ht22-cells
#11
JOURNAL ARTICLE
Jianghao Cheng, Gaoyizhou Li, Liping Yang, Pu Chen, Xiaohua Duan
The present study investigated the inhibitory and neuroprotective effects of Rubia yunnanensis alcohol extract (RY-A) on oxidative stress induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in HT22 cells. In vitro cultured HT22 cells were randomly divided into control, OGD/R, OGD/R + 100 µmol/l edaravone and OGD/R + 10, 20 and 40 µg/ml RY-A groups. Oxygen-sugar deprivation was performed with 10 mmol/l sodium dithionite combined with sugar-free DMEM medium for 2 h, followed by re-glycolization and reoxygenation for 2 h to establish an in vitro OGD/R model...
May 2024: Biomedical Reports
https://read.qxmd.com/read/38544671/prediction-of-underweight-short-stature-and-microcephaly-based-on-brain-diffusion-weighted-imaging-sequence-in-neonates-with-stage-2-of-hypoxic-ischemic-encephalopathy-a-follow-up-study
#12
JOURNAL ARTICLE
Mohammad Golshan Tafti, Marjan Jafari, Seyed Reza Mirjalili, Razieh Fallah, Farimah Shamsi
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE), caused due to reduced oxygenation and brain blood flow, occurs in 1-8 per 1000 live full-term births in developed countries and up to 26 per 1000 live in the developing world. The growth status of survivors of birth HIE has not been evaluated sufficiently. OBJECTIVE: This study evaluated, the growth parameters (weight, height, and head circumference) of neonates with Sarnat stage.2 of HIE at 6, 10, and 12 months and its relationship with findings of neonatal brain diffusion-weighted imaging (DWI) sequence...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38544630/idiopathic-ventricular-tachycardia-in-the-presence-of-triple-vessel-coronary-artery-disease-a-case-report
#13
Nazima Khatun, Adam Kurnick, Jonathan Francois, Adam S Budzikowski, Louis Salciccioli, Sabu John
Exercise-induced ventricular tachycardia undergoes ischemia evaluation; however, it is important to identify idiopathic ventricular tachycardia in patients with concomitant coronary artery disease and radiofrequency ablations can be lifesaving. We report a case of exercise-induced right and left ventricular outflow tract ventricular tachycardia in a patient with triple vessel coronary artery disease.
February 2024: Curēus
https://read.qxmd.com/read/38544474/brcc3-mediates-inflammation-and-pyroptosis-in-cerebral-ischemia-reperfusion-injury-by-activating-the-nlrp6-inflammasome
#14
JOURNAL ARTICLE
Xiaohuan Huang, Junyi Tan, Yanyan Ji, Jing Luo, Yong Zhao, Jing Zhao
AIMS: Neuroinflammation and pyroptosis are key mediators of cerebral ischemia/reperfusion (I/R) injury-induced pathogenic cascades. BRCC3, the human homolog of BRCC36, is implicated in neurological disorders and plays a crucial role in neuroinflammation and pyroptosis. However, its effects and potential mechanisms in cerebral I/R injury in mice are unclear. METHODS: Cellular localization of BRCC3 and the interaction between BRCC3 and NLRP6 were assessed. Middle cerebral artery occlusion/reperfusion (MCAO) and oxygen-glucose deprivation/reoxygenation (OGD/R) models were established in mice and HT22 cells, respectively, to simulate cerebral I/R injury in vivo and in vitro...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38544413/five-year-outcomes-of-the-gore-viabahn-endoprosthesis-for-the-treatment-of-complex-femoropopliteal-lesions-from-a-japanese-postmarket-surveillance-study
#15
JOURNAL ARTICLE
Osamu Iida, Takao Ohki, Yoshimitsu Soga, Nobuhiro Suematsu, Tatsuya Nakama, Terutoshi Yamaoka, Kazuki Tobita, Shigeo Ichihashi
Introduction: The safety and effectiveness of the GORE VIABAHN Endoprosthesis for treatment of symptomatic patients with peripheral artery disease (PAD) and complex femoropopliteal (FP) lesions was assessed in a real-world Japanese practice setting. Methods : A prospective, multicenter, postmarket surveillance study was conducted from 2016 to 2017 at 64 sites in Japan. Symptomatic patients with PAD and FP lesions ⩾ 10 cm and reference vessel diameters ranging from 4.0 to 7.5 mm were eligible for enrollment...
March 27, 2024: Vascular Medicine
https://read.qxmd.com/read/38543310/preparation-of-nanoparticles-loaded-with-membrane-impermeable-peptide-ac3-i-and-its-protective-effect-on-myocardial-ischemia-and-reperfusion
#16
JOURNAL ARTICLE
Yi Liu, Yingyi Niu, Wenjie Zhang, Kaikai Wang, Tianqing Liu, Weizhong Zhu
PURPOSE: It is well known that inhibition of Ca2+ /calmodulin-dependent protein kinase II (CaMKII) provides cardiac protection in cases of myocardial ischemia-reperfusion injury. However, there are currently no cytoplasm-impermeable drugs that target CaMKII. The aim of this study was to develop curcumin albumin nanoparticles (HSA-CCM NPs) containing AC3-I and investigate their protective effects on hypoxia-reoxygenation (H/R)-induced injuries in adult rat cardiomyocytes and ischemia-reperfusion (I/R) injuries in isolated rat hearts...
March 18, 2024: Pharmaceutics
https://read.qxmd.com/read/38543171/transcriptome-wide-5-methylcytosine-profiling-of-lncrnas-in-the-mouse-cerebral-ischemia-model
#17
JOURNAL ARTICLE
Chao Zhang, Junpeng Gao, Dan Xiong, Yan Zhao
An increasing body of research has demonstrated the significant role of long non-coding RNAs (lncRNAs) in the pathogenesis of stroke. They can actively contribute to the disease's progression either by directly participating in its pathogenesis or by acting as mediators through competing endogenous RNA (ceRNA) mechanisms. Concurrently, epigenetics plays a pivotal role in the pathological mechanisms underlying stroke. Epigenetic factors serve as valuable markers for disease progression, diagnostic biomarkers, and novel therapeutic targets...
March 18, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543139/therapeutic-potential-of-targeting-the-perk-signaling-pathway-in-ischemic-stroke
#18
REVIEW
Xinyuan Yu, Lihong Dang, Ran Zhang, Wei Yang
Many pathologic states can lead to the accumulation of unfolded/misfolded proteins in cells. This causes endoplasmic reticulum (ER) stress and triggers the unfolded protein response (UPR), which encompasses three main adaptive branches. One of these UPR branches is mediated by protein kinase RNA-like ER kinase (PERK), an ER stress sensor. The primary consequence of PERK activation is the suppression of global protein synthesis, which reduces ER workload and facilitates the recovery of ER function. Ischemic stroke induces ER stress and activates the UPR...
March 8, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543095/exploring-the-mechanism-of-salvianolic-acid-b-against-myocardial-ischemia-reperfusion-injury-based-on-network-pharmacology
#19
JOURNAL ARTICLE
Qianping Mao, Chongyu Shao, Huifen Zhou, Li Yu, Yida Bao, Yali Zhao, Jiehong Yang, Haitong Wan
This study aimed to explore the mechanisms through which salvianolic acid B (Sal-B) exerts its effects during myocardial ischemia-reperfusion injury (MI/RI), aiming to demonstrate the potential pharmacological characteristics of Sal-B in the management of coronary heart disease. First, Sal-B-related targets and MI/RI-related genes were compiled from public databases. Subsequent functional enrichment analyses using the protein-protein interaction (PPI) network, gene ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) predicted the core targets and approaches by which Sal-B counters MI/RI...
February 28, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542516/gender-specific-renoprotective-pathways-in-%C3%AE-mupa-transgenic-mice-subjected-to-acute-kidney-injury
#20
JOURNAL ARTICLE
Heba Abd Alkhaleq, Shadi Hamoud, Israel Hacker, Tony Karram, Ahmad Fokra, Aviva Kabala, Zaid Abassi
Acute kidney injury (AKI) is a serious health concern with high morbidity and high mortality worldwide. Recently, sexual dimorphism has become increasingly recognized as a factor influencing the severity of the disease. This study explores the gender-specific renoprotective pathways in αMUPA transgenic mice subjected to AKI. αMUPA transgenic male and female mice were subjected to ischemia-reperfusion (I/R)-AKI in the presence or absence of orchiectomy, oophorectomy, and L-NAME administration. Blood samples and kidneys were harvested 48 h following AKI for the biomarkers of kidney function, renal injury, inflammatory response and intracellular pathway sensing of or responding to AKI...
March 21, 2024: International Journal of Molecular Sciences
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