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https://www.readbyqxmd.com/read/29773555/prostaglandin-f-2%C3%AE-facilitates-hepatic-glucose-production-through-camkii%C3%AE-p38-foxo1-signaling-pathway-in-fasting-and-obesity
#1
Yuanyang Wang, Shuai Yan, Bing Xiao, Shengkai Zuo, Qianqian Zhang, Guilin Chen, Yu Yu, Di Chen, Qian Liu, Yi Liu, Yujun Shen, Ying Yu
Gluconeogenesis is drastically increased in patients with type 2 diabetes and accounts for increased fasting plasma glucose concentrations. Circulating prostaglandin (PG) F2α is also markedly elevated in diabetes mellitus; however, whether and how PGF2α regulates hepatic glucose metabolism remain unknown. Here, we demonstrated that PGF2α receptor (F-prostanoid receptor; FP) was upregulated in livers of mice upon fasting- and diabetic stress. Hepatic deletion of the FP receptor suppressed fasting-induced hepatic gluconeogenesis, whereas FP overexpression enhanced hepatic gluconeogenesis in mice...
May 17, 2018: Diabetes
https://www.readbyqxmd.com/read/29768506/genome-wide-classification-evolutionary-analysis-and-gene-expression-patterns-of-the-kinome-in-gossypium
#2
Jun Yan, Guilin Li, Xingqi Guo, Yang Li, Xuecheng Cao
The protein kinase (PK, kinome) family is one of the largest families in plants and regulates almost all aspects of plant processes, including plant development and stress responses. Despite their important functions, comprehensive functional classification, evolutionary analysis and expression patterns of the cotton PK gene family has yet to be performed on PK genes. In this study, we identified the cotton kinomes in the Gossypium raimondii, Gossypium arboretum, Gossypium hirsutum and Gossypium barbadense genomes and classified them into 7 groups and 122-24 subfamilies using software HMMER v3...
2018: PloS One
https://www.readbyqxmd.com/read/29765357/the-wisdom-of-honeybee-defenses-against-environmental-stresses
#3
REVIEW
Guilin Li, Hang Zhao, Zhenguo Liu, Hongfang Wang, Baohua Xu, Xingqi Guo
As one of the predominant pollinator, honeybees provide important ecosystem service to crops and wild plants, and generate great economic benefit for humans. Unfortunately, there is clear evidence of recent catastrophic honeybee colony failure in some areas, resulting in markedly negative environmental and economic effects. It has been demonstrated that various environmental stresses, including both abiotic and biotic stresses, functioning singly or synergistically, are the potential drivers of colony collapse...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29755475/impact-of-a-3-months-vegetarian-diet-on-the-gut-microbiota-and-immune-repertoire
#4
Chenchen Zhang, Andrea Björkman, Kaiye Cai, Guilin Liu, Chunlin Wang, Yin Li, Huihua Xia, Lijun Sun, Karsten Kristiansen, Jun Wang, Jian Han, Lennart Hammarström, Qiang Pan-Hammarström
The dietary pattern can influence the immune system directly, but may also modulate it indirectly by regulating the gut microbiota. Here, we investigated the effect of a 3-months lacto-ovo-vegetarian diet on the diversity of gut microbiota and the immune system in healthy omnivorous volunteers, using high-throughput sequencing technologies. The short-term vegetarian diet did not have any major effect on the diversity of the immune system and the overall composition of the metagenome. The prevalence of bacterial genera/species with known beneficial effects on the intestine, including butyrate-producers and probiotic species and the balance of autoimmune-related variable genes/families were, however, altered in the short-term vegetarians...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29745165/-ecological-risk-assessment-of-typical-karst-basin-based-on-land-use-change-a-case-study-of-lijiang-river-basin-southern-china
#5
Jin Long Hu, Zhi Xiang Zhou, Ming Jun Teng, Nan Luo
Taking Lijiang River basin as study area, and based on the remote sensing images of 1973, 1986, 2000 and 2013, the land-use data were extracted, the ecological risk index was constructed, and the characteristics of spatiotemporal variation of ecological risk were analyzed by "3S" technique. The results showed that land use structure of Lijiang River basin was under relatively reasonable state and it was constantly optimizing during 1973-2013. Overall, the ecological risk of Lijiang River basin was maintained at a low level...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29740458/differential-responses-of-stomata-and-photosynthesis-to-elevated-temperature-in-two-co-occurring-subtropical-forest-tree-species
#6
Guilin Wu, Hui Liu, Lei Hua, Qi Luo, Yixue Lin, Pengcheng He, Shiwei Feng, Juxiu Liu, Qing Ye
Global warming could increase leaf transpiration and soil evaporation, which can potentially cause water deficit to plants. As valves, leaf stomata can control plant water loss and carbon gain, particularly under water stress conditions. To investigate the responses of stomata to elevated temperature in Schima superba and Syzygium rehderianum , two co-occurring subtropical forest dominant tree species, functional traits related to gas exchange, stomatal anatomy, and drought resistance were measured under control and warming environment (ca...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29669327/effects-of-baicalin-on-diabetic-cardiac-autonomic-neuropathy-mediated-by-the-p2y12-receptor-in-rat-stellate-ganglia
#7
Xuan Sheng, Jiayue Wang, Jingjing Guo, Yurong Xu, Huaide Jiang, Chaoran Zheng, Zixi Xu, Yuanruohan Zhang, Hongyu Che, Shangdong Liang, Gaochun Zhu, Guilin Li
BACKGROUND/AIMS: Chronic diabetic hyperglycemia can damage various of organ systems and cause serious complications. Although diabetic cardiac autonomic neuropathy (DCAN) is the primary cause of death in diabetic patients, its pathogenesis remains to be fully elucidated. Baicalin is a flavonoid extracted from Scutellaria baicalensis root and has antibacterial, diuretic, anti-inflammatory, anti- metamorphotic, and antispasmodic effects. Our study explored the effects of baicalin on enhancing sympathoexcitatory response induced by DCAN via the P2Y12 receptor...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29651500/outcome-of-endovascular-treatment-for-acute-basilar-artery-occlusion-in-the-modern-era-a-single-institution-experience
#8
Chuanhui Li, Wenbo Zhao, Chuanjie Wu, Shuyi Shang, Jian Chen, Ming Ren, Jiangang Duan, Qingfeng Ma, Guilin Li, Yunzhou Zhang, Hongqi Zhang, Liqun Jiao, Xunming Ji
PURPOSE: The beneficial effect of endovascular treatment (EVT) for patients with acute basilar artery occlusion (ABAO) remains uncertain. The purpose of the present study was to evaluate clinical outcome of EVT for patients with ABAO and analyze prognostic factors of good outcome. METHODS: From our prospectively established database, we reviewed all patients with ABAO receiving EVT during January 2014 to December 2016. Baseline characteristics and outcomes were evaluated...
April 12, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29642555/a-novel-design-framework-for-structures-materials-with-enhanced-mechanical-performance
#9
Jie Liu, Xiaonan Fan, Guilin Wen, Qixiang Qing, Hongxin Wang, Gang Zhao
Abstract : Structure/material requires simultaneous consideration of both its design and manufacturing processes to dramatically enhance its manufacturability, assembly and maintainability. In this work, a novel design framework for structural/material with a desired mechanical performance and compelling topological design properties achieved using origami techniques is presented. The framework comprises four procedures, including topological design, unfold, reduction manufacturing, and fold. The topological design method, i...
April 9, 2018: Materials
https://www.readbyqxmd.com/read/29599843/platelet-rich-plasma-shows-beneficial-effects-for-patients-with-knee-osteoarthritis-by-suppressing-inflammatory-factors
#10
Guilin Huang, Sha Hua, Tuanmin Yang, Jianbing Ma, Wenxing Yu, Xiujin Chen
Knee osteoarthritis is a degenerative disease that may develop due ageing, obesity, strain, congenital abnormal joints, joint deformity or trauma. It is caused by many factors, such as degradation of articular cartilage injury, joint edge and subchondral bone hyperplasia of reactivity. Platelet-rich plasma (PRP) is an autologous blood sample that contains highly concentrated platelets and multiple cell growth factors. PRP promotes synovial cell proliferation and differentiation and may recover cartilage morphology...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29593769/genetic-loci-conferring-reducing-sugar-accumulation-and-conversion-of-cold-stored-potato-tubers-revealed-by-qtl-analysis-in-a-diploid-population
#11
Guilin Xiao, Wei Huang, Hongju Cao, Wei Tu, Haibo Wang, Xueao Zheng, Jun Liu, Botao Song, Conghua Xie
Cold-induced sweetening (CIS) caused by reducing sugar (RS) accumulation during storage in low temperature in potato tubers is a critical factor influencing the quality of fried potato products. The reconditioning (REC) by arising storage temperature is a common measure to lower down RS. However, both CIS and REC are genotype-dependent and the genetic basis remains uncertain. In the present study, with a diploid potato population with broad genetic background, four reproducible QTL of CIS and two of REC were resolved on chromosomes 5, 6, and 7 of the CIS-sensitive parent and chromosomes 5 and 11 of the CIS-resistant parent, respectively, implying that these two traits may be genetically independent...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29570056/ultracompact-implantable-design-with-integrated-wireless-power-transfer-and-rf-transmission-capabilities
#12
Guilin Sun, Badar Muneer, Ying Li, Qi Zhu
This paper presents an ultracompact design of biomedical implantable devices with integrated wireless power transfer (WPT) and RF transmission capabilities for implantable medical applications. By reusing the spiral coil in an implantable device, both RF transmission and WPT are realized without the performance degradation of both functions in ultracompact size. The complete theory of WPT based on magnetic resonant coupling is discussed and the design methodology of an integrated structure is presented in detail, which can guide the design effectively...
April 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29569081/identification-of-a-melatonin-receptor-type-1a-gene-accmtnr1a-in-apis-cerana-cerana-and-its-possible-involvement-in-the-response-to-low-temperature-stress
#13
Guilin Li, Yanming Zhang, Yong Ni, Ying Wang, Baohua Xu, Xingqi Guo
It is known that melatonin plays an indispensable role in the defense against some environment-induced stresses. The melatonin receptor (MTNR) is also closely linked to the environmental stress response in mammals. However, little is known about the function of the MTNR in insects, including honeybees. In this study, we identified a MTNR from Apis cerana cerana named AccMTNR1A, which contained a typical seven-transmembrane domain common to this family of receptors. A subcellular localization analysis showed that AccMTNR1A was localized in the cytomembrane...
March 22, 2018: Die Naturwissenschaften
https://www.readbyqxmd.com/read/29555596/aberrant-expression-of-the-sfrp-and-wif1-genes-in-invasive-non-functioning-pituitary-adenomas
#14
Wang Song, Liu Qian, Guo Jing, Feng Jie, Shan Xiaosong, Liu Chunhui, Li Yangfang, Li Guilin, Hua Gao, Zhang Yazhuo
Non-functioning pituitary adenomas (NFPAs) are the most common pituitary tumors and mainly invade the sphenoid, cavernous sinus or dura mate. Aberrant regulation of the Wnt signaling pathway plays an important role in tumorigenesis. This study was designed to investigate the relationships between secreted frizzled-related proteins (sFRPs), WIF1 genes and the invasion of NFPAs by tissue microassays (TMAs) of samples from 163 patients. Significantly weaker staining of WIF1 and sFRP4 were detected in the invasive group compared with the non-invasive group by TMAs (p = 0...
March 16, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29545910/cd10-positive-mantle-cell-lymphoma-clinicopathologic-and-prognostic-study-of-30-cases
#15
Jie Xu, L Jeffrey Medeiros, Annapurna Saksena, Michael Wang, Jiehao Zhou, Jingyi Li, C Cameron Yin, Guilin Tang, Lifu Wang, Pei Lin, Shaoying Li
Mantle cell lymphoma is usually negative for CD10 which is useful in distinguishing MCL from other CD10 + B cell lymphomas. Here we assessed the clinicopathologic features of 30 cases of CD10+ MCL, the largest series to date in the English literature, and compared them with a group of 212 typical MCL cases (CD5+, CD10-negative, CD23-negative, cyclin D1+). The 30 patients with CD10+ MCL included 17 men and 13 women with a median age of 68 years. Compared with CD10-negative MCL, patients with CD10+ MCL showed a lower male predominance ( p = 0...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29541391/acute-myeloid-leukemia-with-t-4-12-q12-p13-an-aggressive-disease-with-frequent-involvement-of-pdgfra-and-etv6
#16
Jingyi Li, Jie Xu, Lynne V Abruzzo, Guilin Tang, Shaoying Li, M James You, Gary Lu, Elias J Jabbour, Qi Deng, Carlos E Bueso-Ramos, L Jeffrey Medeiros, C Cameron Yin
We describe the clinical, morphologic, immunophenotypic and molecular genetic features of 15 cases of acute myeloid leukemia (AML) with t(4;12)(q12;p13). There were 9 men and 6 women, with a median age of 50 years (range, 17-76). Most patients had hypercellular bone marrow with a median blast count of 58% and multilineage dysplasia. Flow cytometry analysis showed myeloid lineage with blasts positive for CD13, CD33, CD34, CD38, CD117 and HLA-DR. Interestingly, aberrant CD7 expression was detected in 12/14 cases, and myeloperoxidase was either negative (3/15) or positive in only a small subset of the blasts (12/15)...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29540784/early-direct-competition-does-not-determine-the-community-structure-in-a-desert-riparian-forest
#17
Guilin Wu, Shaowei Jiang, Hui Liu, Shidan Zhu, Duoduo Zhou, Ying Zhang, Qi Luo, Jun Li
In riparian zones along the Tarim River in northeastern China, the co-dominance by Populus euphratica and Tamarix ramosissima at the early succession stage shifts to P. euphratica dominance in the late stages. However, little is known about how this shift is mediated by the highly variable water conditions in riparian zones. Here we conducted a mesocosm experiment in which we measured the physiological and morphological traits of these two co-occuring species grown in mixtures under simulated favorable groundwater condition and no groundwater availability...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29515243/reply-to-lambros-et-al
#18
Zhenya Tang, Jianjun Zhang, Hui Chen, Selina Lu, Joanne Cheng, Guilin Tang, L Jeffrey Medeiros
No abstract text is available yet for this article.
March 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29505838/lead-exposure-inhibits-expression-of-sv2c-through-nrsf
#19
Meiyuan Yang, Yaobin Li, Lei Hu, Dan Luo, Yi Zhang, Xue Xiao, Guilin Li, Lixia Zhang, Gaochun Zhu
Lead (Pb) exposure has been shown to affect presynaptic neurotransmitter release in the animal and cell models. The mechanism by which Pb exposure impairs neurotransmitter release remains unknown. In this study, we aimed to investigate the effect of Pb exposure on synaptic vesicle protein 2C (SV2C) and its molecular mechanism. SV2C promoter region contains a neuron-restrictive silencer element (NRSE) binding motif. Neuron-restrictive silencer factor (NRSF) is a transcription repressor that regulates gene expression by binding to NRSE...
April 1, 2018: Toxicology
https://www.readbyqxmd.com/read/29480238/diagnosis-of-lymphoepithelial-carcinoma-in-parotid-gland-with-three-dimensional-computed-tomography-angiography-reconstruction-a-case-report
#20
Li Yao, Yuanyuan Zhang, Qijun Chen, Shuai Wang, Qingjian Wang, Jie Yi, Ligang Zhang, Ethan L Matz, Xiaohua Hu, Guilin Huang
Lymphoepithelial carcinoma (LEC) is an uncommon malignant neoplasm. Due to the complicated anatomical structure of the human head, standard imaging modalities including ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) scan remain limited in detection of salivary tumors. We used three-dimensional computed tomography angiography (3D-CT angiography) for the assessment and pre-operative surgical planning of facial fractures of a case with LEC. The study results demonstrated that 3D-CT angiography provided an insightful approach to preoperative evaluation in the treatment of salivary tumors...
2018: Journal of X-ray Science and Technology
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