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https://www.readbyqxmd.com/read/28930646/lncrna-snhg1-enhances-cell-proliferation-migration-and-invasion-in-cervical-cancer
#1
Yang Liu, Yanling Yang, Lei Li, Yuan Liu, Peng Geng, Guilin Li, Hongjuan Song
OBJECTIVE: This study investigated effects of lncRNA SNHG1 on the proliferation, migration and invasion of cervical cancer. METHODS: Three pairs of cervical cancer tissue samples and their corresponding adjacent samples were analyzed using Human LncRNA Microarray V3.0 chip for differential analysis. The expression of SNHG1 in cervical cancer cell lines was verified by qRT-PCR. The CCK8 assays and Colony formation assays were used to study the changes in cell proliferation...
September 20, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28926953/short-circuit-fault-detection-and-classification-using-empirical-wavelet-transform-and-local-energy-for-electric-transmission-line
#2
Nantian Huang, Jiajin Qi, Fuqing Li, Dongfeng Yang, Guowei Cai, Guilin Huang, Jian Zheng, Zhenxin Li
In order to improve the classification accuracy of recognizing short-circuit faults in electric transmission lines, a novel detection and diagnosis method based on empirical wavelet transform (EWT) and local energy (LE) is proposed. First, EWT is used to deal with the original short-circuit fault signals from photoelectric voltage transformers, before the amplitude modulated-frequency modulated (AM-FM) mode with a compactly supported Fourier spectrum is extracted. Subsequently, the fault occurrence time is detected according to the modulus maxima of intrinsic mode function (IMF₂) from three-phase voltage signals processed by EWT...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28925017/early-treatment-with-resolvin-e1-facilitates-myocardial-recovery-from-ischemia-in-mice
#3
Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang, Ying Yu
BACKGROUND AND PURPOSE: An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. The purpose of this study was to investigate the potential effects of RvE1 on cardiac function recovery after MI in mice. EXPERIMENTAL APPROACH: Acute MI was induced by surgical ligation of the left anterior descending artery (LAD) in mice...
September 19, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28919906/screening-for-natural-inhibitors-of-topoisomerases-i-from-rhamnus-davurica-by-affinity-ultrafiltration-and-high-performance-liquid-chromatography-mass-spectrometry
#4
Guilin Chen, Mingquan Guo
Topoisomerase I (Topo I) catalyzes topological interconversion of duplex DNA during DNA replication and transcription, and has been deemed as important antineoplastic targets. In this study, the fraction R.d-60 from ethyl acetate extracts of Rhamnus davurica showed higher inhibitory rates against SGC-7901 and HT-29 compared with the R.d-30 fraction in vitro. However, the specific active components of R.d-60 fraction remain elusive. To this end, a method based on bio-affinity ultrafiltration and high performance liquid chromatography/electrospray mass spectrometry (HPLC- ESI-MS/MS) was developed to rapidly screen and identify the Topo I inhibitors in this fraction...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28919433/the-p2x7-receptor-in-dorsal-root-ganglia-is-involved-in-hiv-gp120-associated-neuropathic-pain
#5
Bing Wu, Lichao Peng, Jinyan Xie, Lifang Zou, Qicheng Zhu, Huaide Jiang, Zhihua Yi, Shouyu Wang, Yun Xue, Yun Gao, Guilin Li, Shuangmei Liu, Chunping Zhang, Guodong Li, Shangdong Liang, Huangui Xiong
Human immunodeficiency virus (HIV)-associated neuropathic pain is common, and studies have shown that HIV envelope glycoprotein 120 (gp120) can directly stimulate primary sensory afferent neurons causing hyperalgesia. The P2X7 receptor in the dorsal root ganglia (DRG) is involved in pain transmission and is closely related to the inflammatory and immune response. In this study, we aimed to explore the role of the P2X7 receptor in gp120-induced neuropathic pain using a rat model specific for this type of pain...
September 14, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28916708/architectural-delineation-and-molecular-identification-of-extracellular-matrix-in-ascidian-embryos-and-larvae
#6
Jiankai Wei, Guilin Wang, Xiang Li, Ping Ren, Haiyan Yu, Bo Dong
The extracellular matrix (ECM) not only provides essential physical scaffolding for cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis. In this study, we utilized wheat germ agglutinin (WGA) staining to characterize the ECM architecture in ascidian embryos and larvae. The results showed three distinct populations of ECM presenting in Ciona embryogenesis: the outer layer localized at the surface of embryo, an inner layer of notochord sheath and the apical ECM secreted by the notochord...
September 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28914263/coexistent-genetic-alterations-involving-alk-ret-ros1-or-met-in-15-cases-of-lung-adenocarcinoma
#7
Zhenya Tang, Jianjun Zhang, Xinyan Lu, Wei Wang, Hui Chen, Melissa K Robinson, Joanne Cheng, Guilin Tang, L Jeffrey Medeiros
In lung cancer, targetable activating alterations in cancer genes, such as EGFR, ALK, RET, ROS1 and MET, are usually mutually exclusive. Rare lung cancer cases with coexistent alterations of EGFR and ALK or EGFR mutations with RET or ROS1 rearrangements have been reported. In this study, we report 15 patients (3 men and 12 women; 14 Caucasians and 1 African American) with ages ranging from 43 to 81 years (median 60 years) with lung adenocarcinoma in which coexistent alterations of two cancer-associated genes, including ALK, ROS1, or RET rearrangement or MET amplification were present...
September 15, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28901437/implementing-targeted-region-capture-sequencing-for-the-clinical-detection-of-alagille-syndrome-an-efficient-and-cost%C3%A2-effective-method
#8
Tianhong Huang, Guilin Yang, Xiao Dang, Feijian Ao, Jiankang Li, Yizhou He, Qiyuan Tang, Qing He
Alagille syndrome (AGS) is a highly variable, autosomal dominant disease that affects multiple structures including the liver, heart, eyes, bones and face. Targeted region capture sequencing focuses on a panel of known pathogenic genes and provides a rapid, cost‑effective and accurate method for molecular diagnosis. In a Chinese family, this method was used on the proband and Sanger sequencing was applied to validate the candidate mutation. A de novo heterozygous mutation (c.3254_3255insT p.Leu1085PhefsX24) of the jagged 1 gene was identified as the potential disease‑causing gene mutation...
September 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900254/large-manipulative-experiments-revealed-variations-of-insect-abundance-and-trophic-levels-in-response-to-the-cumulative-effects-of-sheep-grazing
#9
Jingchuan Ma, Xunbing Huang, Xinghu Qin, Yong Ding, Jun Hong, Guilin Du, Xinyi Li, Wenyuan Gao, Zhuoran Zhang, Guangjun Wang, Ning Wang, Zehua Zhang
Livestock grazing can affect insects by altering habitat quality; however, the effects of grazing years and intensities on insect abundance and trophic level during manipulative sheep grazing are not well understood. Therefore, we investigated these effects in a large manipulative experiment from 2014 to 2016 in the eastern Eurasian steppe, China. Insect abundance decreased as sheep grazing intensities increased, with a significant cumulative effect occurring during grazing years. The largest families, Acrididae and Cicadellidae, were susceptible to sheep grazing, but Formicidae was tolerant...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878291/map-kinase-interacting-serine-threonine-kinase-2-promotes-proliferation-metastasis-and-predicts-poor-prognosis-in-non-small-cell-lung-cancer
#10
Zhihua Guo, Guilin Peng, Ermao Li, Shaoyan Xi, Yu Zhang, Yong Li, Xiaodong Lin, Guangqiu Li, Qinian Wu, Jianxing He
We hypothesized that MAP kinase-interacting serine/threonine kinase 2 (MNK2) may contribute to non-small cell lung cancer (NSCLC) development, and serve as a new therapeutic target. Immunohistochemical staining evaluated the correlation between MNK2 expression and clinicopathological features in 367 NSCLC cancer tissues. We determined the effects of MNK2 silencing in NSCLC cell lines in vitro and in vivo. RT-PCR and western blotting was used to examine the impact of MNK2 on ERK and AKT pathways. MNK2 was overexpressed in NSCLC cell lines and tumor tissues...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28876063/magnetic-interaction-affecting-the-zero-field-single-molecule-magnet-behaviors-in-isomorphic-ni-ii-2dy-iii-2-and-co-ii-2dy-iii-2-tetranuclear-complexes
#11
Haipeng Wu, Min Li, Sheng Zhang, Hongshan Ke, Yiquan Zhang, Guilin Zhuang, Wenyuan Wang, Qing Wei, Gang Xie, Sanping Chen
Great interest is being shown in investigating magnetic interactions that efficiently influence lanthanide single-molecule magnet behavior. A series of heterometallic complexes [M2Ln2(Hhms)2(CH3COO)6(CH3OH)2(H2O)2]·(NO3)2 (M = Ni(II), Ln = Dy(III) (1), Gd(III) (2), and Y(III) (3); M = Co(II), Ln = Dy(III) (4), Gd(III) (5), and Y(III) (6)) have been prepared with a compartmental Schiff-base ligand, 1-(2-hydroxy-3-methoxybenzylidene)-semicarbazide (H2hms), featuring a zigzag-shaped M(II)-Ln(III)-Ln(III)-M(II) metallic core arrangement...
September 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28870172/the-lysin-motif-containing-proteins-lyp1-lyk7-and-lysme3-play-important-roles-in-chitin-perception-and-defense-against-verticillium-dahliae-in-cotton
#12
Jun Xu, Guilin Wang, Jing Wang, Yongqing Li, Liangliang Tian, Xinyu Wang, Wangzhen Guo
BACKGROUND: Lysin motif (LysM)-containing proteins are important pattern recognition receptors (PRRs) in plants, which function in the perception of microbe-associated molecular patterns (MAMPs) and in the defense against pathogenic attack. To date, the LysM genes have not been systematically analyzed in cotton or effectively utilized for disease resistance. RESULTS: Here, we identified 29, 30, 60, and 56 LysM genes in the four sequenced cotton species, diploid Gossypium raimondii, diploid G...
September 4, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28863294/chlorine-decay-and-trihalomethane-formation-following-ferrate-vi-preoxidation-and-chlorination-of-drinking-water
#13
Cong Li, Feng Luo, Feilong Dong, Jingguo Zhao, Tuqiao Zhang, Guilin He, Leslie Cizmas, Virender K Sharma
This paper presents the effect of preoxidation with ferrate(VI) (Fe(VI)O4(2-), Fe(VI)) prior to chlorination on chlorine decay and formation of disinfection by-products in filtered raw water from a full-scale drinking water treatment plant. The rate of chlorine decay became significantly faster as the concentration of ferrate(VI) increased. Chlorine degradation followed two first-order decay reactions with rate constants k1 and k2 for fast and slow decay, respectively. Kinetic modeling established the relationships between k1 and k2 and varying dosages of chlorine and ferrate(VI)...
August 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28860345/concurrent-diagnosis-of-crlf2-rearranged-and-ph-acute-lymphoblastic-leukemia-a-report-of-four-patients
#14
Nitin Jain, Xinyan Lu, Naval Daver, Beenu Thakral, Sa A Wang, Sergej Konoplev, Keyur Patel, Rashmi Kanagal-Shamanna, Marcus Valentine, Guilin Tang, Naveen Pemmaraju, Jeffrey Jorgensen, Partow Kebriaei, Cesar A Nunez, William Wierda, Elias Jabbour, Kathryn G Roberts, Charles G Mullighan, Hagop Kantarjian, Marina Konopleva
No abstract text is available yet for this article.
August 31, 2017: Haematologica
https://www.readbyqxmd.com/read/28855989/t-cell-immunoglobulin-mucin-3-expression-in-invasive-ductal-breast-carcinoma-clinicopathological-correlations-and-association-with-tumor-infiltration-by-cytotoxic-lymphocytes
#15
Huan Zhang, Rong Xiang, Bin Wu, Jinlong Li, Guilin Luo
As a negative regulatory molecule, T-cell immunoglobulin and mucin domain-3 (Tim-3) is closely associated with tumor immunological tolerance. The aim of this study was to investigate Tim-3 expression in invasive ductal breast cancer (IDC), its effect on clinicopathological parameters and its association with cytotoxic lymphocyte infiltration. Tim-3 protein expression was measured in 150 paraffin-embedded IDC specimens and 100 paired normal breast tissue specimens by immunohistochemistry. It was demonstrated that the infiltration of the tumor by CD8(+) T cells was significantly higher compared with that of normal tissue, and the Tim-3 expression on CD8(+) T cells was higher in IDC tissue compared with that in normal tissue; the differences were statistically significant (both P-values=0...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28853311/spatial-and-temporal-variation-of-h-and-o-isotopic-compositions-of-the-xijiang-river-system-southwest-china
#16
Guilin Han, Pin Lv, Yang Tang, Zhaoliang Song
Ratios of stable isotopes of hydrogen and oxygen ((2)H/(1)H and (18)O/(16)O) in river waters were measured to investigate the hydrological pathway of the Xijiang River, Southwest China. The δ(2)H and δ(18)O values of river waters exhibit significant spatial and temporal variations and the isotopic compositions vary with elevation, temperature and precipitation of the recharge area. Spatially, δ(18)O values of river waters from high mountain areas are lower than those from the lower reaches of the Xijiang River due to lower temperature and higher elevation for the recharge area...
August 30, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28840511/nanoparticle-encapsulated-emodin-decreases-diabetic-neuropathic-pain-probably-via-a-mechanism-involving-p2x3-receptor-in-the-dorsal-root-ganglia
#17
Lin Li, Xuan Sheng, Shanhong Zhao, Lifang Zou, Xinyao Han, Yingxin Gong, Huilong Yuan, Liran Shi, Lili Guo, Tianyu Jia, Shuangmei Liu, Bing Wu, Zhihua Yi, Hui Liu, Yun Gao, Guilin Li, Guodong Li, Chunping Zhang, Hong Xu, Shangdong Liang
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). More than 90% of all cases of DM belong to type 2 diabetes mellitus (T2DM). Emodin is the main active component of Radix et rhizoma rhei and has anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. Nanoparticle encapsulation of drugs is beneficial for drug targeting and bioavailability as well as for lowering drug toxicity side effects. The aim of this study was to investigate the effects of nanoparticle-encapsulated emodin (nano emodin) on diabetic neuropathic pain (DNP) mediated by the Purin 2X3 (P2X3) receptor in the dorsal root ganglia (DRG)...
August 24, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28835440/clonal-chromosomal-abnormalities-appearing-in-philadelphia-negative-metaphases-during-cml-treatment
#18
Ghayas C Issa, Hagop Kantarjian, Graciela Nogueras Gonzalez, Gautam Borthakur, Guilin Tang, William Wierda, Koji Sasaki, Nicholas J Short, Farhad Ravandi, Tapan Kadia, Keyur Patel, Raja Luthra, Alessandra Ferrajoli, Guillermo Garcia-Manero, Mary Beth Rios, Sara Dellasala, Elias Jabbour, Jorge E Cortes
Clonal chromosomal abnormalities in Philadelphia chromosome-negative metaphases (CCA/Ph-) emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated with tyrosine kinase inhibitors (TKI). We assessed the characteristics and prognostic impact of 598 patients with CP-CML treated on clinical trials with various TKIs. CCA/Ph- occurred in 58 patients (10%) and the most common were - Y in 25 (43%) and trisomy 8 in 7 patients (12%). Response to TKI therapy was similar for patients with CCA/Ph- and those without additional chromosomal abnormalities (ACAs)...
August 23, 2017: Blood
https://www.readbyqxmd.com/read/28827078/p2y12-shrna-treatment-relieved-hiv-gp120-induced-neuropathic-pain-in-rats
#19
Liran Shi, Bing Wu, Zhihua Yi, Shanhong Zhao, Lifang Zou, Lin Li, Huilong Yuan, Tianyu Jia, Shuangmei Liu, Hui Liu, Yun Gao, Guilin Li, Hong Xu, Chunping Zhang, Shangdong Liang
Human immunodeficiency virus (HIV) envelope glycoprotein (glycoprotein 120, gp120) can induce chronic neuropathic pain by directly stimulating primary sensory afferent neurons. Activation of satellite glial cells (SGCs) in dorsal root ganglia (DRG) plays an important role in the transmission of neuropathic pain. The P2Y12 receptor is expressed in SGCs of DRG. In this study, we investigated the role of the P2Y12 receptor in HIV gp120-induced neuropathic pain. The results showed that peripheral nerve exposure to HIV gp120 increased mechanical and thermal hyperalgesia in gp120-treated model rats...
August 18, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28821581/comparison-of-karyotyping-tcl1-fluorescence-in-situ-hybridisation-and-tcl1-immunohistochemistry-in-t-cell-prolymphocytic-leukaemia
#20
Yi Sun, Guilin Tang, Zhihong Hu, Beenu Thakral, Roberto N Miranda, L Jeffrey Medeiros, Sa A Wang
AIMS: T cell prolymphocytic leukaemia (T-PLL) is defined as an aggressive T cell leukaemia composed of small to medium-sized lymphocytes with a mature T cell immunophenotype. Most of these cases are known to be associated with inv(14q11q32)/t(14;14)(q11;q32) or rarely t(X;14)(q28;q11). However, T-PLL can show variations in clinical presentation, morphology or immunophenotype that can make a diagnosis of T-PLL challenging. We aim to explore the value of ancillary testing in the diagnosis of T-PLL...
August 18, 2017: Journal of Clinical Pathology
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