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Tianeptine AND mTOR

Mi Kyoung Seo, Roger S McIntyre, Hye Yeon Cho, Chan Hong Lee, Sung Woo Park, Rodrigo B Mansur, Gyung-Mee Kim, Jun Hyung Baek, Young Sup Woo, Jung Goo Lee, Young Hoon Kim
RATIONALE: Recent studies have demonstrated that mTORC1 activation may be related to antidepressant action. However, the relationship between mTORC1 signaling activation and currently prescribed antidepressants remains unclear. OBJECTIVE: The aim of the present study was to determine whether alterations in mTORC1 signaling are observable following treatment with tianeptine under toxic conditions induced by B27 deprivation. Additionally, we investigated whether this drug affects synaptic proteins, neurite outgrowth, and spine density via mTORC1 signaling...
July 2016: Psychopharmacology
Michal Korostynski, Marcin Piechota, Jaroslaw Dzbek, Wiktor Mlynarski, Klaudia Szklarczyk, Barbara Ziolkowska, Ryszard Przewlocki
BACKGROUND: Despite their widespread use, the biological mechanisms underlying the efficacy of psychotropic drugs are still incompletely known; improved understanding of these is essential for development of novel more effective drugs and rational design of therapy. Given the large number of psychotropic drugs available and their differential pharmacological effects, it would be important to establish specific predictors of response to various classes of drugs. RESULTS: To identify the molecular mechanisms that may initiate therapeutic effects, whole-genome expression profiling (using 324 Illumina Mouse WG-6 microarrays) of drug-induced alterations in the mouse brain was undertaken, with a focus on the time-course (1, 2, 4 and 8 h) of gene expression changes produced by eighteen major psychotropic drugs: antidepressants, antipsychotics, anxiolytics, psychostimulants and opioids...
2013: BMC Genomics
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