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curcumin pain postop

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https://www.readbyqxmd.com/read/25520223/the-comparison-of-preemptive-analgesic-effects-of-curcumin-and-diclofenac
#1
COMPARATIVE STUDY
K E Nurullahoglu, N Okudan, M Belviranli, M Oz
OBJECTIVE: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. MATERIAL AND METHODS: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg-(1), p...
2014: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/24816565/antinociceptive-effects-of-curcumin-in-a-rat-model-of-postoperative-pain
#2
Qing Zhu, Yuehua Sun, Xiaodi Yun, Yuntao Ou, Wei Zhang, Jun-Xu Li
Curcumin is a principal ingredient of traditional Chinese medicine, Curcuma Longa, which possesses a variety of pharmacological activities including pain relief. Preclinical studies have demonstrated that curcumin has antinociceptive effects for inflammatory and neuropathic pain. This study examined the effects of curcumin in a rat model of postoperative pain. A surgical incision on the right hind paw induced a sustained mechanical hyperalgesia that lasted for 5 days. Acute curcumin treatment (10-40 mg/kg, p...
2014: Scientific Reports
https://www.readbyqxmd.com/read/24755847/curcumin-treatment-attenuates-pain-and-enhances-functional-recovery-after-incision
#3
Peyman Sahbaie, Yuan Sun, De-Yong Liang, Xiao-You Shi, J David Clark
BACKGROUND: Acute pain after surgery remains moderate to severe for 20% to 30% of patients despite advancements in the use of opioids, adjuvant drugs, and regional anesthesia. Depending on the type of surgery, 10% to 50% of patients experience persistent pain postoperatively, and there are no established methods for its prevention. Curcumin (diferuloylmethane) is one of the phenolic constituents of turmeric that has been used in Eastern traditional medicine as an antiseptic, antioxidant, anti-inflammatory, and analgesic agent...
June 2014: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/24474673/effects-of-curcumin-on-pain-threshold-and-on-the-expression-of-nuclear-factor-%C3%AE%C2%BA-b-and-cx3c-receptor-1-after-sciatic-nerve-chronic-constrictive-injury-in-rats
#4
Hong Cao, Jin-Wei Zheng, Jia-Jia Li, Bo Meng, Jun Li, Ren-Shan Ge
OBJECTIVE: To investigate the effects of curcumin on pain threshold and the expressions of nuclear factor κ B (NF-κ B) and CX3C chemokine receptor 1 (CX3CR1) in spinal cord and dorsal root ganglion (DRG) of the rats with sciatic nerve chronic constrictive injury. METHODS: One hundred and twenty male Sprague Dawley rats, weighing 220-250 g, were randomly divided into 4 groups. Sham surgery (sham) group: the sciatic nerves of rats were only made apart but not ligated; chronic constrictive injury (CCI) group: the sciatic nerves of rats were only ligated without any drug treatment; curcumin treated injury (Cur) model group: the rats were administrated with curcumin 100 mg/(kg·d) by intraperitoneal injection for 14 days after CCI; solvent control (SC) group: the rats were administrated with the solvent at the same dose for 14 days after CCI...
November 2014: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/21671126/efficacy-of-turmeric-curcumin-in-pain-and-postoperative-fatigue-after-laparoscopic-cholecystectomy-a-double-blind-randomized-placebo-controlled-study
#5
RANDOMIZED CONTROLLED TRIAL
Krishna Adit Agarwal, C D Tripathi, Brij B Agarwal, Satish Saluja
OBJECTIVE: Better patient-reported outcomes (PROs) of laparoscopic cholecystectomy (LC) are premised upon PROs such as postoperative pain and fatigue. These PROs are indices of convalescence and return to normal activity. Curcumin (turmeric) is used in India for traumatic pain and fatigue for its anti-inflammatory/antioxidant and tissue modulation/healing properties. We studied the effect of curcumin on pain and postoperative fatigue in patients of LC. METHODS AND PROCEDURES: From July to September 2009, 50 consecutive day-care LC candidates were enrolled for a prospective, double-blind randomized placebo-controlled study...
December 2011: Surgical Endoscopy
https://www.readbyqxmd.com/read/20976480/do-dietary-spices-impair-the-patient-reported-outcomes-for-stapled-hemorrhoidopexy-a-randomized-controlled-study
#6
RANDOMIZED CONTROLLED TRIAL
Brij B Agarwal
BACKGROUND: Postoperative pain is a concern for patients seeking hemorrhoid surgery. Stapled hemorrhoidopexy is popular due to better patient-reported outcomes (PROs). Pain is the index of PROs. Posthemorrhoidectomy patients usually opt for a spice-free diet due to fear of pain or anal pruritus induced by spices. Curcumin and peprin (spice constituents) have powerful antiinflammatory and antioxidant properties. Ability to resume a normal taste-habituated meal may improve PRO quality of life...
May 2011: Surgical Endoscopy
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