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https://www.readbyqxmd.com/read/28362353/ergosteryl-2-naphthoate-an-ergosterol-derivative-exhibits-antidepressant-effects-mediated-by-the-modification-of-gabaergic-and-glutamatergic-systems
#1
Mingzhu Lin, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang, Guosheng Tang, Ruiqing Wang
Phytosterols are a kind of natural component including sitosterol, campesterol, avenasterol, ergosterol (Er) and others. Their main natural sources are vegetable oils and their processed products, followed by grains, by-products of cereals and nuts, and small amounts of fruits, vegetables and mushrooms. In this study, three new Er monoester derivatives were obtained from the reflux reaction with Er: organic acids (furoic acid, salicylic acid and 2-naphthoic acid), 1-Ethylethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride (EDCI) and 4-dimethylaminopyridine (DMAP) in dichloromethane...
March 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28359918/the-effects-of-desipramine-fluoxetine-or-tianeptine-on-changes-in-bulbar-bdnf-levels-induced-by-chronic-social-instability-stress-and-inflammation
#2
Marta M Nowacka-Chmielewska, Daniela Kasprowska, Monika Paul-Samojedny, Anna M Bielecka-Wajdman, Jarosław J Barski, Andrzej Małecki, Ewa Obuchowicz
BACKGROUND: Stress is a major predisposing factor in the development of psychiatric disorders and potential source of augmented inflammatory processes in the brain. Increasing body of evidence shows an important role of alterations in the olfactory bulbs (OBs) function in stress-related disorders. The aim of the present study was to investigate the impact of antidepressants on the alterations of brain-derived neurotrophic factor (BDNF) induced by lipopolysaccharide (LPS) in female rats subjected to chronic social instability stress (CSIS)...
January 17, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28352358/alterations-in-vegf-expression-induced-by-antidepressant-drugs-in-female-rats-under-chronic-social-stress
#3
Marta Maria Nowacka-Chmielewska, Monika Paul-Samojedny, Anna Maria Bielecka-Wajdman, Jarosław Jerzy Barski, Ewa Obuchowicz
Vascular endothelial growth factor (VEGF) is thought to serve a role in neurogenesis and the stress response. Although a definite link between the action of antidepressants and VEGF has not been identified, it is assumed that VEGF, as a neurotrophic factor, serves an important role in the effects of antidepressant treatment. To examine this, the present study subjected adult female rats to four weeks of social instability stress and measured the effect of antidepressant treatment on the expression of VEGF. Firstly, endocrine markers of stress and body weight were measured in parallel with behavioral tests prior to and following subjection to stress...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28303899/the-behavioral-effects-of-the-antidepressant-tianeptine-require-the-mu-opioid-receptor
#4
Benjamin Adam Samuels, Katherine M Nautiyal, Andrew C Kruegel, Marjorie R Levinstein, Valerie M Magalong, Madalee M Gassaway, Steven G Grinnell, Jaena Han, Michael A Ansonoff, John E Pintar, Jonathan A Javitch, Dalibor Sames, René Hen
Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors (SSRIs), are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown mechanism of action. We recently reported that tianeptine is a full agonist at the mu-opioid receptor (MOR). Here we demonstrate that the acute and chronic antidepressant-like behavioral effects of tianeptine in mice require MOR...
March 17, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28223757/attenuation-of-dickkopf-1-induced-hair-growth-inhibition-in-cultured-human-hair-follicles-by-tianeptine
#5
Hyun Sik Jeong, Mi Hee Kwack, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28081469/anti-osteoporotic-effects-of-an-antidepressant-tianeptine-on-ovariectomized-rats
#6
Osama A Alkhamees, Abdulaziz S Al-Roujayee, Hatem M Abuohashish, Mohammed M Ahmed
In the current investigation, the potential alleviating effects of tianeptine against bone loss induced in ovariectomized (OVX) rats was determined. Two weeks following a bilateral ovariectomy operation, tianeptine treatment (12.5 and 25mg/kg/twice/d) was initiated and continued for twenty-eight consecutive days. Changes in serum and urinary bone turnover biomarkers and osteoclastogenesis-inducing factors were estimated. The femoral bone mineral content was estimated using inductively-coupled-plasma mass spectrometry...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28063625/regulation-of-insulin-receptor-phosphorylation-in-the-brains-of-prenatally-stressed-rats-new-insight-into-the-benefits-of-antidepressant-drug-treatment
#7
Katarzyna Głombik, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
A growing body of evidence supports the involvement of disturbances in the brain insulin pathway in the pathogenesis of depression. On the other hand, data concerning the impact of antidepressant drug therapy on brain insulin signaling remain scare and insufficient. We determinated the influence of chronic treatment with antidepressant drugs (imipramine, fluoxetine and tianeptine) on the insulin signaling pathway of the brain of adult prenatally stressed rats. 3-month-old prenatally stressed and control rats were treated for 21 days with imipramine, fluoxetine or tianeptine (10mg/kg/day i...
February 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27862243/antidepressant-adherence-patterns-in-older-patients-use-of-a-clustering-method-on-a-prescription-database
#8
David Braunstein, Amélie Hardy, Quentin Boucherie, Elisabeth Frauger, Olivier Blin, Gaétan Gentile, Joëlle Micallef
According to the World Health Organization, depression will become the second most important cause of disability worldwide by 2020. Our objective was to identify patterns of adherence to antidepressant treatments in older patients using several indicators of adherence and to characterize these patterns in terms of medication exposure. We conducted a retrospective cohort study using the French National Health Insurance reimbursement database. Incident antidepressant users aged more than 65 were included from July 1, 2010, to June 30, 2011, and followed up for 18 months...
November 14, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27641318/effects-of-tianeptine-on-the-development-and-maintenance-of-mechanical-allodynia-in-a-rat-model-of-neuropathic-pain
#9
Bong Ha Heo, Jae Yun Shin, Keun Suk Park, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Kim
We validate the analgesic efficacy of tianeptine by different administration routes and timing in a rat model of neuropathic pain. Neuropathic pain was induced by ligating the L5 and L6 spinal nerves in male Sprague-Dawley rats, and mechanical allodynia was assessed using von Frey filaments. The effects of orally administered tianeptine and pretreatment with tianeptine (intrathecally or intraperitoneally) on mechanical allodynia were assessed. Oral and preemptive intrathecal administration of tianeptine significantly increased the paw withdrawal threshold but preemptive intraperitoneal administration did not...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27626082/effect-of-tianeptine-on-depressed-tinnitus-patients
#10
Soo Min Hwang, Sae Hee Lim, Dong Ju Oh, Sung Kyun Kim, Hak Hyun Jung, Gi Jung Im
BACKGROUND AND OBJECTIVES: Tianeptine is a tricyclic antidepressant that has a novel pharmacological property: it increases the reuptake of 5-hydroxytryptamine. Recent studies have reported that the prevalence of depression is greater in patients with tinnitus than in control subjects who do not have tinnitus. The purpose of this study was to assess the efficacy of tianeptine for the relief of tinnitus, especially in patients with depressive mood. SUBJECTS AND METHODS: Among a total of 52 tinnitus patients, 15 had depressive mood...
September 2016: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/27604299/differential-effects-of-tianeptine-on-the-dorsal-hippocampal-volume-of-rats-submitted-to-maternal-separation-followed-by-chronic-unpredictable-stress-in-adulthood
#11
Antonella Pollano, María I Zalosnik, Patricia E Durando, Marta M Suárez
Early maternal separation (MS) may produce lasting effects in the dorsal hippocampus (DH) that can change its response to chronic stress in adulthood. Chronic stress affects DH morphology and function, but tianeptine (an anti-depressant) can reverse the stress-induced morphological impairments. Morphologic alterations of hippocampus can affect contextual memory. Therefore, we evaluated the effect of tianeptine in MS and chronically stressed rats, on: 1) volume of the DH and its areas using stereology, and 2) hippocampal dependent memory using a fear conditioning test...
September 8, 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27561095/anticonvulsant-activity-of-the-antidepressant-drug-tianeptine-against-pentylenetetrazole-induced-seizures-mitigates-cognitive-impairment-in-rats
#12
Kh Reeta, Pankaj Prabhakar, Yogendra K Gupta
Treatment of depression, a common comorbidity in patients with epilepsy, is restricted as certain antidepressants are considered to be proconvulsants. In contrast, anticonvulsant effects have been reported with some antidepressants. In the present study, the effect of tianeptine, an antidepressant, was evaluated against pentylenetetrazole (PTZ)-induced seizures, cognitive impairment and oxidative stress in rats. Tianeptine was administered in three doses (20, 40 and 80 mg/kg) 30 min before PTZ (60 mg/kg, intraperitoneally)...
October 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27392529/novel-series-of-tacrine-tianeptine-hybrids-synthesis-cholinesterase-inhibitory-activity-s100b-secretion-and-a-molecular-modeling-approach
#13
Marco Antonio Ceschi, Jessie Sobieski da Costa, João Paulo Bizarro Lopes, Viktor Saraiva Câmara, Leandra Franciscato Campo, Antonio César de Amorim Borges, Carlos Alberto Saraiva Gonçalves, Daniela Fraga de Souza, Eduardo Luis Konrath, Ana Luiza Martins Karl, Isabella Alvim Guedes, Laurent Emmanuel Dardenne
Tianeptine was linked to various 9-aminoalkylamino-1,2,3,4-tetrahydroacridines using EDC·HCl/HOBt to afford a series of tacrine-tianeptine hybrids. The hybrids were tested for their ability to inhibit AChE and BuChE and IC50 values in the nanomolar concentration scale were obtained. AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). Furthermore, the compounds 2g and 2e were able to reduce the in vitro basal secretion of S100B, suggesting its therapeutic action in some cases or stages of Alzheimer's disease...
October 4, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27378793/neurotrophin-genes-and-antidepressant-worsening-suicidal-ideation-a-prospective-case-control-study
#14
Géraldine Voegeli, Nicolas Ramoz, Tatyana Shekhtman, Philippe Courtet, Philip Gorwood, John R Kelsoe
BACKGROUND: Antidepressant-worsening suicidal ideation is a rare but serious phenomenon. This study aimed to test for association between antidepressant-worsening suicidal ideation and polymorphisms of BDNF/NTRK2 neurotrophin pathway genes, known to be involved in depression and suicide. METHODS: This was a case-control study comparing patients with antidepressant-worsening suicidal ideation to patients without. Patients were collected from the GENESE cohort (3771 depressed tianeptine-treated outpatients)...
November 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27371898/traxoprodil-augments-the-antidepressant-like-activity-of-agomelatine-but-not-of-mianserin-or-tianeptine-in-the-forced-swim-test-in-mice
#15
Weronika Stasiuk, Anna Serefko, Aleksandra Szopa, Elżbieta Wyska, Katarzyna Świąder, Piotr Wlaź, Ewa Poleszak
BACKGROUND: The main objective of our study was to evaluate the influence of traxoprodil on the activity of the atypical antidepressant drugs (agomelatine, mianserin, tianeptine). METHODS: The forced swim test (FST) in mice was used to determine the antidepressant-like activity of the tested agents. Drugs levels in brain tissue were assessed by a high performance liquid chromatography method. RESULTS: Concurrent intraperitoneal administration of per se ineffective doses of traxoprodil (10mg/kg) and agomelatine (20mg/kg) shortened the immobility time of animals in the FST...
October 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27274258/treatment-response-in-relation-to-subthreshold-bipolarity-in-patients-with-major-depressive-disorder-receiving-antidepressant-monotherapy-a-post-hoc-data-analysis-komdd-study
#16
Young-Min Park, Bun-Hee Lee
BACKGROUND: The aim of this observational study was to determine whether subthreshold bipolarity affects treatment response and remission in patients with major depressive disorder receiving antidepressant (AD) monotherapy over a 6-month follow-up period. METHODS: Seventy-eight patients with major depressive disorder were stratified into two subgroups according to the presence of subthreshold bipolarity, identified using the Korean version of the Mood Disorder Questionnaire (K-MDQ), which classifies patients as positive for a screening of bipolarity based on the cutoff for the total K-MDQ score (ie, 7 points)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27188165/molecular-profile-of-dissociative-drug-ketamine-in-relation-to-its-rapid-antidepressant-action
#17
Joanna Ficek, Magdalena Zygmunt, Marcin Piechota, Dzesika Hoinkis, Jan Rodriguez Parkitna, Ryszard Przewlocki, Michal Korostynski
BACKGROUND: The NMDA receptor antagonist ketamine was found to act as a fast-acting antidepressant. The effects of single treatment were reported to persist for days to weeks, even in otherwise treatment-refractory cases. Identification of the mechanisms underlying ketamine's antidepressant action may permit development of novel drugs, with similar clinical properties but lacking psychotomimetic, sedative and other side effects. METHODS: We applied whole-genome microarray profiling to analyze detailed time-course (1, 2, 4 and 8 h) of transcriptome alterations in the striatum and hippocampus following acute administration of ketamine, memantine and phencyclidine in C57BL/6 J mice...
May 17, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27129862/tianeptine-induces-mtorc1-activation-in-rat-hippocampal-neurons-under-toxic-conditions
#18
Mi Kyoung Seo, Roger S McIntyre, Hye Yeon Cho, Chan Hong Lee, Sung Woo Park, Rodrigo B Mansur, Gyung-Mee Kim, Jun Hyung Baek, Young Sup Woo, Jung Goo Lee, Young Hoon Kim
RATIONALE: Recent studies have demonstrated that mTORC1 activation may be related to antidepressant action. However, the relationship between mTORC1 signaling activation and currently prescribed antidepressants remains unclear. OBJECTIVE: The aim of the present study was to determine whether alterations in mTORC1 signaling are observable following treatment with tianeptine under toxic conditions induced by B27 deprivation. Additionally, we investigated whether this drug affects synaptic proteins, neurite outgrowth, and spine density via mTORC1 signaling...
July 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26952787/tianeptine-olanzapine-and-fluoxetine-show-similar-restoring-effects-on-stress-induced-molecular-changes-in-mice-brain-an-ft-ir-study
#19
Sevgi Türker-Kaya, Oğuz Mutlu, İpek K Çelikyurt, Furuzan Akar, Güner Ulak
Chronic stress which can cause a variety of disorders and illness ranging from metabolic and cardiovascular to mental leads to alterations in content, structure and dynamics of biomolecules in brain. The determination of stress-induced changes along with the effects of antidepressant treatment on these parameters might bring about more effective therapeutic strategies. In the present study, we investigated unpredictable chronic mild stress (UCMS)-induced changes in biomolecules in mouse brain and the restoring effects of tianeptine (TIA), olanzapine (OLZ) and fluoxetine (FLX) on these variations, by Fourier transform infrared (FT-IR) spectroscopy...
May 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/26934888/the-effect-of-chronic-tianeptine-administration-on-the-brain-mitochondria-direct-links-with-an-animal-model-of-depression
#20
Katarzyna Głombik, Aneta Stachowicz, Rafał Olszanecki, Joanna Ślusarczyk, Ewa Trojan, Władysław Lasoń, Marta Kubera, Bogusława Budziszewska, Michael Spedding, Agnieszka Basta-Kaim
A growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drugs on the brain's mitochondrial protein profile. The aim of this study was to investigate the impact of chronic treatment with an atypical antidepressant drug-tianeptine-on the mitochondria-enriched subproteome profile in the hippocampus and the frontal cortex of 3-month-old male rats following a prenatal stress procedure...
December 2016: Molecular Neurobiology
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