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https://www.readbyqxmd.com/read/27862243/antidepressant-adherence-patterns-in-older-patients-use-of-a-clustering-method-on-a-prescription-database
#1
David Braunstein, Amélie Hardy, Quentin Boucherie, Elisabeth Frauger, Olivier Blin, Gaétan Gentile, Joëlle Micallef
According to the World Health Organization, depression will become the second most important cause of disability worldwide by 2020. Our objective was to identify patterns of adherence to antidepressant treatments in older patients using several indicators of adherence and to characterize these patterns in term of medication exposure. We conducted a retrospective cohort study using the French National Health Insurance reimbursement database. Incident antidepressant users aged more than 65 were included from July 1, 2010 to June 30, 2011 and followed-up for 18 months...
November 14, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27641318/effects-of-tianeptine-on-the-development-and-maintenance-of-mechanical-allodynia-in-a-rat-model-of-neuropathic-pain
#2
Bong Ha Heo, Jae Yun Shin, Keun Suk Park, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Kim
We validate the analgesic efficacy of tianeptine by different administration routes and timing in a rat model of neuropathic pain. Neuropathic pain was induced by ligating the L5 and L6 spinal nerves in male Sprague-Dawley rats, and mechanical allodynia was assessed using von Frey filaments. The effects of orally administered tianeptine and pretreatment with tianeptine (intrathecally or intraperitoneally) on mechanical allodynia were assessed. Oral and preemptive intrathecal administration of tianeptine significantly increased the paw withdrawal threshold but preemptive intraperitoneal administration did not...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27626082/effect-of-tianeptine-on-depressed-tinnitus-patients
#3
Soo Min Hwang, Sae Hee Lim, Dong Ju Oh, Sung Kyun Kim, Hak Hyun Jung, Gi Jung Im
BACKGROUND AND OBJECTIVES: Tianeptine is a tricyclic antidepressant that has a novel pharmacological property: it increases the reuptake of 5-hydroxytryptamine. Recent studies have reported that the prevalence of depression is greater in patients with tinnitus than in control subjects who do not have tinnitus. The purpose of this study was to assess the efficacy of tianeptine for the relief of tinnitus, especially in patients with depressive mood. SUBJECTS AND METHODS: Among a total of 52 tinnitus patients, 15 had depressive mood...
September 2016: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/27604299/differential-effects-of-tianeptine-on-the-dorsal-hippocampal-volume-of-rats-submitted-to-maternal-separation-followed-by-chronic-unpredictable-stress-in-adulthood
#4
Antonella Pollano, María I Zalosnik, Patricia E Durando, Marta M Suárez
Early maternal separation (MS) may produce lasting effects in the dorsal hippocampus (DH) that can change its response to chronic stress in adulthood. Chronic stress affects DH morphology and function, but tianeptine (an anti-depressant) can reverse the stress-induced morphological impairments. Morphologic alterations of hippocampus can affect contextual memory. Therefore, we evaluated the effect of tianeptine in MS and chronically stressed rats, on: 1) volume of the DH and its areas using stereology, and 2) hippocampal dependent memory using a fear conditioning test...
September 8, 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27561095/anticonvulsant-activity-of-the-antidepressant-drug-tianeptine-against-pentylenetetrazole-induced-seizures-mitigates-cognitive-impairment-in-rats
#5
Kh Reeta, Pankaj Prabhakar, Yogendra K Gupta
Treatment of depression, a common comorbidity in patients with epilepsy, is restricted as certain antidepressants are considered to be proconvulsants. In contrast, anticonvulsant effects have been reported with some antidepressants. In the present study, the effect of tianeptine, an antidepressant, was evaluated against pentylenetetrazole (PTZ)-induced seizures, cognitive impairment and oxidative stress in rats. Tianeptine was administered in three doses (20, 40 and 80 mg/kg) 30 min before PTZ (60 mg/kg, intraperitoneally)...
October 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27392529/novel-series-of-tacrine-tianeptine-hybrids-synthesis-cholinesterase-inhibitory-activity-s100b-secretion-and-a-molecular-modeling-approach
#6
Marco Antonio Ceschi, Jessie Sobieski da Costa, João Paulo Bizarro Lopes, Viktor Saraiva Câmara, Leandra Franciscato Campo, Antonio César de Amorim Borges, Carlos Alberto Saraiva Gonçalves, Daniela Fraga de Souza, Eduardo Luis Konrath, Ana Luiza Martins Karl, Isabella Alvim Guedes, Laurent Emmanuel Dardenne
Tianeptine was linked to various 9-aminoalkylamino-1,2,3,4-tetrahydroacridines using EDC·HCl/HOBt to afford a series of tacrine-tianeptine hybrids. The hybrids were tested for their ability to inhibit AChE and BuChE and IC50 values in the nanomolar concentration scale were obtained. AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). Furthermore, the compounds 2g and 2e were able to reduce the in vitro basal secretion of S100B, suggesting its therapeutic action in some cases or stages of Alzheimer's disease...
October 4, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27378793/neurotrophin-genes-and-antidepressant-worsening-suicidal-ideation-a-prospective-case-control-study
#7
Géraldine Voegeli, Nicolas Ramoz, Tatyana Shekhtman, Philippe Courtet, Philip Gorwood, John R Kelsoe
BACKGROUND: Antidepressant-worsening suicidal ideation is a rare but serious phenomenon. This study aimed to test for association between antidepressant-worsening suicidal ideation and polymorphisms of BDNF/NTRK2 neurotrophin pathway genes, known to be involved in depression and suicide. METHODS: This was a case-control study comparing patients with antidepressant-worsening suicidal ideation to patients without. Patients were collected from the GENESE cohort (3771 depressed tianeptine-treated outpatients)...
November 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27371898/traxoprodil-augments-the-antidepressant-like-activity-of-agomelatine-but-not-of-mianserin-or-tianeptine-in-the-forced-swim-test-in-mice
#8
Weronika Stasiuk, Anna Serefko, Aleksandra Szopa, Elżbieta Wyska, Katarzyna Świąder, Piotr Wlaź, Ewa Poleszak
BACKGROUND: The main objective of our study was to evaluate the influence of traxoprodil on the activity of the atypical antidepressant drugs (agomelatine, mianserin, tianeptine). METHODS: The forced swim test (FST) in mice was used to determine the antidepressant-like activity of the tested agents. Drugs levels in brain tissue were assessed by a high performance liquid chromatography method. RESULTS: Concurrent intraperitoneal administration of per se ineffective doses of traxoprodil (10mg/kg) and agomelatine (20mg/kg) shortened the immobility time of animals in the FST...
October 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27274258/treatment-response-in-relation-to-subthreshold-bipolarity-in-patients-with-major-depressive-disorder-receiving-antidepressant-monotherapy-a-post-hoc-data-analysis-komdd-study
#9
Young-Min Park, Bun-Hee Lee
BACKGROUND: The aim of this observational study was to determine whether subthreshold bipolarity affects treatment response and remission in patients with major depressive disorder receiving antidepressant (AD) monotherapy over a 6-month follow-up period. METHODS: Seventy-eight patients with major depressive disorder were stratified into two subgroups according to the presence of subthreshold bipolarity, identified using the Korean version of the Mood Disorder Questionnaire (K-MDQ), which classifies patients as positive for a screening of bipolarity based on the cutoff for the total K-MDQ score (ie, 7 points)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27188165/molecular-profile-of-dissociative-drug-ketamine-in-relation-to-its-rapid-antidepressant-action
#10
Joanna Ficek, Magdalena Zygmunt, Marcin Piechota, Dzesika Hoinkis, Jan Rodriguez Parkitna, Ryszard Przewlocki, Michal Korostynski
BACKGROUND: The NMDA receptor antagonist ketamine was found to act as a fast-acting antidepressant. The effects of single treatment were reported to persist for days to weeks, even in otherwise treatment-refractory cases. Identification of the mechanisms underlying ketamine's antidepressant action may permit development of novel drugs, with similar clinical properties but lacking psychotomimetic, sedative and other side effects. METHODS: We applied whole-genome microarray profiling to analyze detailed time-course (1, 2, 4 and 8 h) of transcriptome alterations in the striatum and hippocampus following acute administration of ketamine, memantine and phencyclidine in C57BL/6 J mice...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27129862/tianeptine-induces-mtorc1-activation-in-rat-hippocampal-neurons-under-toxic-conditions
#11
Mi Kyoung Seo, Roger S McIntyre, Hye Yeon Cho, Chan Hong Lee, Sung Woo Park, Rodrigo B Mansur, Gyung-Mee Kim, Jun Hyung Baek, Young Sup Woo, Jung Goo Lee, Young Hoon Kim
RATIONALE: Recent studies have demonstrated that mTORC1 activation may be related to antidepressant action. However, the relationship between mTORC1 signaling activation and currently prescribed antidepressants remains unclear. OBJECTIVE: The aim of the present study was to determine whether alterations in mTORC1 signaling are observable following treatment with tianeptine under toxic conditions induced by B27 deprivation. Additionally, we investigated whether this drug affects synaptic proteins, neurite outgrowth, and spine density via mTORC1 signaling...
July 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26952787/tianeptine-olanzapine-and-fluoxetine-show-similar-restoring-effects-on-stress-induced-molecular-changes-in-mice-brain-an-ft-ir-study
#12
Sevgi Türker-Kaya, Oğuz Mutlu, İpek K Çelikyurt, Furuzan Akar, Güner Ulak
Chronic stress which can cause a variety of disorders and illness ranging from metabolic and cardiovascular to mental leads to alterations in content, structure and dynamics of biomolecules in brain. The determination of stress-induced changes along with the effects of antidepressant treatment on these parameters might bring about more effective therapeutic strategies. In the present study, we investigated unpredictable chronic mild stress (UCMS)-induced changes in biomolecules in mouse brain and the restoring effects of tianeptine (TIA), olanzapine (OLZ) and fluoxetine (FLX) on these variations, by Fourier transform infrared (FT-IR) spectroscopy...
May 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/26934888/the-effect-of-chronic-tianeptine-administration-on-the-brain-mitochondria-direct-links-with-an-animal-model-of-depression
#13
Katarzyna Głombik, Aneta Stachowicz, Rafał Olszanecki, Joanna Ślusarczyk, Ewa Trojan, Władysław Lasoń, Marta Kubera, Bogusława Budziszewska, Michael Spedding, Agnieszka Basta-Kaim
A growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drugs on the brain's mitochondrial protein profile. The aim of this study was to investigate the impact of chronic treatment with an atypical antidepressant drug-tianeptine-on the mitochondria-enriched subproteome profile in the hippocampus and the frontal cortex of 3-month-old male rats following a prenatal stress procedure...
December 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26730381/antidepressants-modulate-glycine-action-in-rat-hippocampus
#14
Hyun-Kyung Chang, Khae Hawn Kim, Ki-Woon Kang, Yoo-Jin Kang, Tae-Wook Kim, Hun-Kyung Park, Sung-Eun Kim, Chang-Ju Kim
Antidepressants are drugs that relieve symptoms of depressive disorders. Fluoxetine, tianeptine, and milnacipran are different types of antidepressants, and they have widely been used for relieving of depression symptoms. In the present study, the effects of fluoxetine, tianeptine, and milnacipran on the glycine-induced ion current by nystatin-perforated patch clamp and on the amplitude of field potential in the hippocampal CA1 region by multichannel extracellular recording, MED64, system, were studied. In the present results, fluoxetine, tianeptine, and milnacipran reduced glycine-induced ion current in the hippocampal CA1 neurons in nystatin-perforated patch clamp method...
December 2015: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/26688843/frequent-difficulties-in-the-treatment-of-restless-legs-syndrome-case-report-and-literature-review
#15
REVIEW
Dominika Narowska, Milena Bożek, Katarzyna Krysiak, Jakub Antczak, Justyna Holka-Pokorska, Wojciech Jernajczyk, Adam Wichniak
Restless legs syndrome (RLS) is one of the most common sleep disorders. The purpose of this paper is a case description of the patient suffering from RLS, concurrent with numerous clinical problems. In our patient, during long-term therapy with a dopamine agonist (ropinirole), the phenomenon of the augmentation, defined as an increase in the severity of the RLS symptoms, was observed. The quality of life of the patient was significantly deteriorated. Due to the augmentation of RLS symptoms the dopaminergic drug was gradually withdrawn, and the gabapentin as a second-line drug for the treatment of RLS was introduced...
2015: Psychiatria Polska
https://www.readbyqxmd.com/read/26659818/neonatal-abstinence-syndrome-following-tianeptine-dependence-during-pregnancy
#16
Camille Bence, Alexandre Bonord, Camille Rebillard, Pascal Vaast, Charlotte Alexandre, Renaud Jardri, Benjamin Rolland
Tianeptine, an atypical antidepressant, has been found to exhibit a potential for abuse. The use of therapeutic doses of tianeptine during pregnancy has never raised safety concerns. However, the impact of tianeptine abuse on the mother-child dyad has never been assessed. We report herein the case of a female patient who presented with dependence on tianeptine, with the use of >650 mg of the drug per day. She had 2 successive pregnancies with similar doses. The state of dependence remained unidentified throughout the first pregnancy, but just after delivery, her full-term newborn exhibited unexpected neonatal abstinence syndrome (NAS)...
January 2016: Pediatrics
https://www.readbyqxmd.com/read/26640965/anti-inflammatory-properties-of-tianeptine-on-lipopolysaccharide-induced-changes-in-microglial-cells-involve-toll-like-receptor-related-pathways
#17
Joanna Slusarczyk, Ewa Trojan, Katarzyna Glombik, Anna Piotrowska, Boguslawa Budziszewska, Marta Kubera, Katarzyna Popiolek-Barczyk, Wladyslaw Lason, Joanna Mika, Agnieszka Basta-Kaim
Accumulating evidence suggests that activation of microglia plays a key role in the pathogenesis of depression. Activated microglia produce a wide range of factors whose prolonged or excessive release may lead to brain disorders. Thus, the inhibition of microglial cells may be beneficial in the treatment of depressive diseases. Tianeptine is an atypical antidepressant drug with proven clinical efficacy, but its mechanism of action remains still not fully understood. In the present study, using microglial cultures we investigated whether tianeptine modifies microglial activation after lipopolysaccharide (LPS) stimulation and which intracellular pathways are involved in the activity of this antidepressant...
March 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/26610812/the-beneficial-impact-of-antidepressant-drugs-on-prenatal-stress-evoked-malfunction-of-the-insulin-like-growth-factor-1-igf-1-protein-family-in-the-olfactory-bulbs-of-adult-rats
#18
Ewa Trojan, Katarzyna Głombik, Joanna Ślusarczyk, Bogusława Budziszewska, Marta Kubera, Adam Roman, Władysław Lasoń, Agnieszka Basta-Kaim
Insulin-like growth factor-1 (IGF-1) promotes the growth, differentiation, and survival of both neurons and glial cells, and it is believed to exert antidepressant-like activity. Thus, disturbances in the IGF-1 system could be responsible for the course of depression. To date, there have been no papers showing the impact of chronic antidepressant treatment on the IGF-1 network in the olfactory bulb (OB) in an animal model of depression. Prenatal stress was used as model of depression. Twenty-four 3-month-old male offspring of control and stressed mothers were subjected to behavioral testing (forced swim test)...
February 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/26470856/drug-induced-liver-injury-associated-with-antidepressive-psychopharmacotherapy-an-explorative-assessment-based-on-quantitative-signal-detection-using-different-meddra-terms
#19
Maximilian Gahr, René Zeiss, Dirk Lang, Bernhard J Connemann, Christoph Hiemke, Carlos Schönfeldt-Lecuona
Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach...
June 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26452320/maternal-separation-in-early-life-modifies-anxious-behavior-and-fos-and-glucocorticoid-receptor-expression-in-limbic-neurons-after-chronic-stress-in-rats-effects-of-tianeptine
#20
Verónica Trujillo, Patricia E Durando, Marta M Suárez
Early-life adversity can lead to long-term consequence persisting into adulthood. Here, we assess the implications of an adverse early environment on vulnerability to stress during adulthood. We hypothesized that the interplay between early and late stress would result in a differential phenotype regarding the number of neurons immunoreactive for glucocorticoid receptor (GR-ir) and neuronal activity as assessed by Fos immunoreactivity (Fos-ir) in brain areas related to stress responses and anxiety-like behavior...
2016: Stress: the International Journal on the Biology of Stress
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