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https://www.readbyqxmd.com/read/29773358/-antidepressive-agents-and-hyponatremia-a-literature-review-and-a-case-non-case-study-in-the-french-pharmacovigilance-database
#1
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
https://www.readbyqxmd.com/read/29739134/effects-of-tianeptine-on-adult-rats-following-prenatal-stress
#2
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Young Ock Kim, Jonghoon Seo, Sanghyun Lee, Ik-Hyun Cho, Hak-Jae Kim
Objective: Exposing a pregnant female to stress during the critical period of embryonic fetal brain development increases the risk of psychiatric disorders in the offspring. The objective of this study was to investigate the effect of antidepressant tianeptine on prenatally stressed (PNS) rats. Methods: In this study, a repeated variable stress paradigm was applied to pregnant rats during the last week of gestation. To investigate the effects of antidepressant tianeptine on PNS rats, behavioral and protein expression analyses were performed...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29688573/antidepressants-for-the-treatment-of-people-with-co-occurring-depression-and-alcohol-dependence
#3
REVIEW
Roberta Agabio, Emanuela Trogu, Pier Paolo Pani
BACKGROUND: Alcohol dependence is a major public health problem characterized by recidivism, and medical and psychosocial complications. The co-occurrence of major depression in people entering treatment for alcohol dependence is common, and represents a risk factor for morbidity and mortality, which negatively influences treatment outcomes. OBJECTIVES: To assess the benefits and risks of antidepressants for the treatment of people with co-occurring depression and alcohol dependence...
April 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29618004/the-antidepressant-tianeptine-reverts-synaptic-ampa-receptor-defects-caused-by-deficiency-of-cdkl5
#4
Marco Tramarin, Laura Rusconi, Lara Pizzamiglio, Isabella Barbiero, Diana Peroni, Linda Scaramuzza, Tim Guilliams, David Cavalla, Flavia Antonucci, Charlotte Kilstrup-Nielsen
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a complex neurological disorder, characterised by infantile seizures, impairment of cognitive and motor skills, and autistic features. Loss of Cdkl5 in mice affects dendritic spine maturation and dynamics but the underlying molecular mechanisms are still far from fully understood. Here we show that Cdkl5 deficiency in primary hippocampal neurons leads to deranged expression of the alpha-amino-3-hydroxy-5-methyl-4-iso-xazole propionic acid receptors (AMPA-R)...
March 30, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29582450/tamper-resistant-prescription-forms-for-narcotics-in-france-should-we-generalise-them
#5
Amélie Daveluy, Lucie Sauvaget, Angela Bastien, Maryse Lapeyre-Mestre, Cédric Collin, Nathalie Richard, Françoise Haramburu
In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal midazolam and zolpidem owing to traffic, abuse or diversion. In 2012, to assess the use of standard and tamper-resistant prescription forms and the acceptability of the generalization of the latter to all medicines, a national opinion survey was performed, with a postal questionnaire, within 3 randomized samples of 1,500 prescribers (physicians, dentists and midwives)...
March 27, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29566235/case-reports-of-fatalities-involving-tianeptine-in-the-united-states
#6
Erica L Bakota, Warren C Samms, Teresa R Gray, Deanna A Oleske, Merrill O Hines
Tianeptine is a tricyclic anti-depressant that is also known to have opioid receptor activity. We present two fatal cases of tianeptine intoxication in Texas in which tianeptine was used recreationally. The first case involved a 28-year-old white male found alone on the floor of his locked residence. He had a history of drug abuse but no other toxicological findings. The second case involved a 30-year-old white male found on the floor of the bathroom in his home. Drug paraphernalia and bags labeled as tianeptine powder were found at both scenes...
March 16, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29494783/tianeptine-abuse-and-dependence-in-psychiatric-patients-a-review-of-18-case-reports-in-the-literature
#7
Janusz Springer, Wiesław Jerzy Cubała
Tianeptine is an atypical antidepressant approved in 25 countries for the treatment of depressive syndromes. Tianeptine abuse among psychiatric patients in the community and at inpatient wards has been increasingly reported in recent years. The purpose of this article is to alert clinicians to tianeptine abuse potential and identify any patterns in the literature. We searched the Academic Search Complete, Google Scholar, MEDLINE, Science Citation Index, Scopus, and the Social Sciences Citation Index for articles published between 1960-2017 in any language containing the keywords: "tianeptine abuse," "tianeptine misuse," "tianeptine dependence...
March 1, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29230490/pharmacokinetic-study-of-tianeptine-and-its-active-metabolite-mc5-in-rats-following-different-routes-of-administration-using-a-novel-liquid-chromatography-tandem-mass-spectrometry-analytical-method
#8
Małgorzata Szafarz, Agnieszka Wencel, Krzysztof Pociecha, Filip A Fedak, Piotr Wlaź, Elżbieta Wyska
Tianeptine is an atypical antidepressant with a unique mechanism of action and recently it has been also reported that its major metabolite, compound MC5, possesses pharmacological activity similar to that of the parent drug. The current study aims to investigate the pharmacokinetics (PK) of both tianeptine and MC5 after intravenous or intraperitoneal administration of the parent drug as well as the metabolic ratio of MC5 in rats. To achieve these goals an LC-MS/MS method using the small sample volume for the quantitation of tianeptine and its active metabolite MC5 in rat plasma and liver perfusate has been developed and validated...
February 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29163165/the-modulatory-properties-of-chronic-antidepressant-drugs-treatment-on-the-brain-chemokine-chemokine-receptor-network-a-molecular-study-in-an-animal-model-of-depression
#9
Ewa Trojan, Joanna Ślusarczyk, Katarzyna Chamera, Katarzyna Kotarska, Katarzyna Głombik, Marta Kubera, Agnieszka Basta-Kaim
An increasing number of studies indicate that the chemokine system may be the third major communication system of the brain. Therefore, the role of the chemokine system in the development of brain disorders, including depression, has been recently proposed. However, little is known about the impact of the administration of various antidepressant drugs on the brain chemokine - chemokine receptor axis. In the present study, we used an animal model of depression based on the prenatal stress procedure. We determined whether chronic treatment with tianeptine, venlafaxine, or fluoxetine influenced the evoked by prenatal stress procedure changes in the mRNA and protein levels of the homeostatic chemokines, CXCL12 (SDF-1α), CX3CL1 (fractalkine) and their receptors, in the hippocampus and frontal cortex...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29157077/how-does-early-maternal-separation-and-chronic-stress-in-adult-rats-affect-the-immunoreactivity-of-serotonergic-neurons-within-the-dorsal-raphe-nucleus
#10
Antonella Pollano, Verónica Trujillo, Marta M Suárez
Vulnerability to emotional disorders like depression derives from interactions between early and late environments, including stressful conditions. The serotonin (5HT) system is strongly affected by stress and chronic unpredictable stress can alter the 5HT system. We evaluated the distribution of active serotonergic neurons in the dorsal raphe nucleus (DR) through immunohistochemistry in maternally separated and chronically stressed rats treated with an antidepressant, tianeptine, whose mechanism of action is still under review...
January 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29141251/opioid-receptors-contribute-to-antinociceptive-effect-of-tianeptine-on-colorectal-distension-induced-visceral-pain-in-rats
#11
S Sırrı Bilge, Fatih İlkaya, Özge Darakcı, Engin Çiftcioğlu, Ayhan Bozkurt
Tianeptine is a clinically effective atypical antidepressant with distinct neurochemical properties. In this study, we aimed to investigate the contribution of opioid receptors in the antinociceptive effect of tianeptine on visceral pain in awake rats and to differentiate the subtype and the localization (central and/or peripheral) of these opioid receptors involved in this antinociception. Visceromotor response to noxious colorectal distension (CRD) was quantified with electromyographic recordings, obtained from previously implanted electrodes into the external oblique musculature of rats under anesthesia, before and after tianeptine administration...
2018: Pharmacology
https://www.readbyqxmd.com/read/29073492/tianeptine-is-associated-with-lower-risk-of-suicidal-ideation-worsening-during-the-first-weeks-of-treatment-onset-compared-with-other-antidepressants-a-naturalistic-study
#12
B Nobile, I Jaussent, Ph Gorwood, J Lopez Castroman, E Olié, S Guillaume, Ph Courtet
Worsening of suicidal ideation during the first weeks of antidepressant treatment is a poorly understood phenomenon that prompted regulatory bodies to issue specific warnings. To better understand the causes of this phenomenon, this study compared the risk of suicidal ideation worsening in patients taking different types of antidepressant medications. To this aim, 4017 depressed adult outpatients were followed by general practitioners and psychiatrists throughout France for 6 weeks after prescription of an antidepressant treatment...
January 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28866072/changes-in-the-cannabinoids-receptors-in-rats-following-treatment-with-antidepressants
#13
Irena Smaga, Magdalena Zaniewska, Dawid Gawliński, Agata Faron-Górecka, Przemysław Szafrański, Marek Cegła, Małgorzata Filip
The endocannabinoid (eCB) system plays a significant role in the pathophysiology of depression. The potential participation of this system in the mechanism of action of antidepressants has been highlighted in recent years. The aim of this study was to investigate the expression of cannabinoid (CB) receptors using Western blot and CB1 receptor density using autoradiography after acute or chronic administration of antidepressant drugs [imipramine (IMI, 15mg/kg), escitalopram (ESC, 10mg/kg) and tianeptine (TIA, 10mg/kg)]...
December 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28862386/use-of-antidepressive-agents-as-a-possibility-in-the-management-of-periodontal-diseases-a-systematic-review-of-experimental-studies
#14
REVIEW
Francisco Wilker Mustafa Gomes Muniz, Iracema Matos Melo, Cassiano Kuchenbecker Rösing, Geanne Matos de Andrade, Ricardo Souza Martins, Maria Mônica Studart Mendes Moreira, Rosimary de Sousa Carvalho
Antidepressant agents have anti-inflammatory functions that could be interesting as adjuvants in periodontal therapy. The aim of the present study was to analyze the effect of antidepressive drugs in the management of periodontal disease. The MEDLINE, Scopus, Embase, LILACS, and SciELO databases were searched. To be included, the studies had to be experimental studies; randomized, controlled; double-blinded; or blinded studies. A total of 565 articles were initially searched, of which five were selected for the systematic review...
February 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28833144/retraction-statement-anti-inflammatory-properties-of-tianeptine-on-lipopolysaccharide-induced-changes-in-microglial-cells-involve-toll-like-receptor-related-pathways
#15
(no author information available yet)
'Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways' by Slusarczyk, J., Trojan, E., Glombik, K., Piotrowska, A., Budziszewska, B., Kubera, M., Popiolek-Barczyk, K., Lason, W., Mika, J. and Basta-Kaim, A. The above article from the Journal of Neurochemistry published on 14 February 2016 on Wiley Online Library ( www.onlinelibrary.com), and in Volume 136, pp. 958-970, is being retracted by agreement between the corresponding author Agnieszka Basta-Kaim, the Journal's Editor-in-Chief Jörg Schulz, and John Wiley & Sons Ltd...
September 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28742625/online-sales-of-unscheduled-pharmaceutical-agents-a-case-report-of-tianeptine-use-in-the-united-states
#16
Swapnil Gupta, Ryan Wallace, Jordan Sloshower
: Tianeptine is a tricyclic antidepressant that stimulates mu-opioid receptors at high doses. It is marketed and used across Europe and Latin America as an antidepressant, but is not approved by the Food and Drug Administration for use in the United States. In the United States, tianeptine is sold through online health stores as a cognition enhancer, dietary supplement, or as research chemical. We report the case of a 36-year-old man with a history of major depressive disorder, responsive to sertraline, who turned to the unmonitored use of tianeptine purchased online to treat residual feelings of apathy and boredom...
September 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28706449/effects-of-tianeptine-on-symptoms-of-fibromyalgia-via-bdnf-signaling-in-a-fibromyalgia-animal-model
#17
Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28541419/acute-toxicity-from-intravenous-use-of-the-tricyclic-antidepressant-tianeptine
#18
Sara K Dempsey, Justin L Poklis, Kacie Sweat, Kirk Cumpston, Carl E Wolf
Tianeptine (7-[([3-chloro-6,11]-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl) amino] heptanoic acid S, S dioxide) is a tricyclic compound prescribed as an antidepressant in European countries, but is not currently approved for use in the United States. There are few published case reports of tianeptine intoxication. Presented is the first case of acute toxicity associated with the intravenous use of tianeptine. A 36-year-old male intentionally injected tianeptine powder intravenously to "help him see into the future"...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28535568/tianeptine-reduces-mechanical-allodynia-in-spinal-nerve-ligated-and-chemotherapy-induced-neuropathic-mice
#19
Seong Min Han, Young Hoon Kim, Hyeon Uk Jo, Jung Ah Kwak, Hue Jung Park
BACKGROUND: Spinal nerve-ligated neuropathy and chemotherapy-induced neuropathy produce a persistent tactile allodynia in mice. Tianeptine is an antidepressant that exhibits structural similarities to tricyclic antidepressants but has distinct neurochemical properties. OBJECTIVE: Here we examined the effects of intraperitoneal (i.p.) tianeptine on allodynia in spinal nerve-ligated and chemotherapy-induced neuropathic mice. STUDY DESIGN: A randomized, experimental trial...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28450192/do-the-accelerating-actions-of-tianeptine-and-l-arginine-on-cortical-spreading-depression-interact-an-electrophysiological-analysis-in-young-and-adult-rats
#20
Luciana Maria Silva de Seixas Maia, Angela Amancio-Dos-Santos, Paula Catirina Pereira da Silva Germano, Anna Carolina Santos Marinho Falcão, Desirré Duda-de-Oliveira, Rubem Carlos Araújo Guedes
In the rat, we previously demonstrated that serotonin-enhancing drugs impair cortical spreading depression (CSD) and that l-arginine (arginine) treatment enhances CSD. Here, we investigated the interaction between topical application of the serotonin uptake enhancer tianeptine and systemic arginine administration on CSD. From postnatal day 7-28, female Wistar rats (n=40) received by gavage 300mg/Kg/day arginine (n=20) or water (n=20). Half of the arginine- or water-treated rats underwent CSD recording at 30-40days of age (young), while the other half was recorded at 90-120days (adult)...
May 22, 2017: Neuroscience Letters
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