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https://www.readbyqxmd.com/read/30016501/arrhythmogenic-mechanisms-of-obstructive-sleep-apnoea-in-heart-failure-patients
#1
Karan R Chadda, Ibrahim T Fazmin, Shiraz Ahmad, Haseeb Valli, Charlotte E Edling, Christopher L-H Huang, Kamalan Jeevaratnam
Heart failure (HF) affects 23 million people worldwide and results in 300,000 annual deaths. It is associated with many comorbidities, such as obstructive sleep apnoea (OSA), and risk factors for both conditions overlap. 11% of HF patients have OSA and 7.7% of OSA patients have left ventricular ejection fraction <50% with arrhythmias being a significant comorbidity in HF and OSA patients. 40% of HF patients develop atrial fibrillation (AF) and 30-50% of deaths from cardiac causes in HF patients are from sudden cardiac death...
July 16, 2018: Sleep
https://www.readbyqxmd.com/read/30014849/kcne1-tunes-the-sensitivity-of-k-v-7-1-to-polyunsaturated-fatty-acids-by-moving-turret-residues-close-to-the-binding-site
#2
Johan E Larsson, H Peter Larsson, Sara I Liin
The voltage-gated potassium channel KV 7.1 and the auxiliary subunit KCNE1 together form the cardiac IKs channel, which is a proposed target for future anti-arrhythmic drugs. We previously showed that polyunsaturated fatty acids (PUFAs) activate KV 7.1 via an electrostatic mechanism. The activating effect was abolished when KV 7.1 was co-expressed with KCNE1, as KCNE1 renders PUFAs ineffective by promoting PUFA protonation. PUFA protonation reduces the potential of PUFAs as anti-arrhythmic compounds. It is unknown how KCNE1 promotes PUFA protonation...
July 17, 2018: ELife
https://www.readbyqxmd.com/read/30010807/cardiac-resynchronization-is-pro-arrhythmic-in-the-absence-of-reverse-ventricular-remodelling-a-systematic-review-and-meta-analysis
#3
Bishoy Deif, Brennan Ballantyne, Fahad Almehmadi, Michael Mikhail, William F McIntyre, Jaimie Manlucu, Raymond Yee, John L Sapp, Jason D Roberts, Jeff S Healey, Peter Leong-Sit, Anthony S Tang
Aims: Cardiac Resynchronization Therapy (CRT) has been shown to reduce mortality and heart failure (HF) hospitalization but its effects on the rate of ventricular arrhythmias (VAs) appears to be neutral. We hypothesize that CRT with LV epicardial stimulation is inherently pro-arrhythmic and increases VA rates in the absence of reverse ventricular remodelling while conferring an anti-arrhythmic effect in mechanical responders. Methods and Results: In this systematic review and meta-analysis, we considered retrospective cohort, prospective cohort and randomized controlled trials comparing VA rates between cardiac resynchronization therapy-defibrillator (CRT-D) non-responders, CRT-D responders and those with implantable cardioverter defibrillator (ICD) only...
July 14, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/30009098/ranolazine-for-prevention-of-atrial-fibrillation-after-cardiac-surgery-a-systematic-review
#4
REVIEW
Nirav Patel, Jeffery Kluger
Postoperative atrial fibrillation (POAF) remains a major risk after cardiac surgery and is associated with an increased risk of stroke, length of stay, mortality, and cost. Ranolazine, an anti-anginal drug, also has anti-arrhythmic properties. The present study is to evaluate the effectiveness of ranolazine in preventing POAF after cardiac surgery. We searched the literature for clinical studies published up to August 2017 with a pre-defined inclusion and exclusion criteria. We identified four studies with a total of 754 patients of which 300 patients received ranolazine; there was a 14% decrease in POAF occurrence following cardiac surgery compared to 32% in the control group...
May 6, 2018: Curēus
https://www.readbyqxmd.com/read/30006658/from-early-beginnings-to-elaborate-tools-contribution-of-german-electrophysiology-to-the-interventional-treatment-of-cardiac-arrhythmias-the-german-cardiac-society-welcomes-esc-in-munich-2018
#5
REVIEW
Thomas Fink, Michael Schlüter, Karl-Heinz Kuck
Catheter ablation evolved from the early days of cardiac electrophysiology (EP), in which invasive electrophysiological studies were mainly a tool to find the correct diagnosis and to evaluate the most effective anti-arrhythmic drug for the patient. Today, catheter ablation is the most effective treatment option for patients suffering from supraventricular and ventricular arrhythmias. The understanding of cardiac arrhythmias and treatment strategies improved because of physicians and scientists from all over the world...
July 13, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/30005151/amiodarone-refractory-electrical-storm-post-revascularization-for-anterior-st-elevation-myocardial-infarction-a-case-report-and-brief-review-of-the-literature
#6
Chirag K Desai, Udit Bhatnagar, Maria Stys
"Electrical storm" is a life-threatening condition defined as the occurrence of at least two episodes of malignant ventricular arrhythmia in a 24-hour period despite anti-arrhythmic therapy. It leads to unpredictable degrees of clinical instability - in the most severe cases mechanical support for circulation and oxygenation and for definitive therapy radiofrequency ablation or cardiac sympathetic denervation. We describe a case of medication refractory electrical storm complicating severe left ventricular dysfunction after an anterior ST-elevation myocardial infarction...
June 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/30003959/early-experience-with-intravenous-sotalol-in-children-with-and-without-congenital-heart-disease
#7
Santiago O Valdés, Christina Y Miyake, Mary C Niu, Caridad M de la Uz, S Yukiko Asaki, Andrew P Landstrom, Andrew E Schneider, Craig G Rusin, Raajen Patel, Wilson W Lam, Jeffrey J Kim
BACKGROUND: Arrhythmias are common in the pediatric population. In patients unable to take oral medications or in need of acute therapy, options of intravenous (IV) anti-arrhythmics are limited. Recently IV sotalol has become readily available, but experience in children is limited. OBJECTIVE: To describe our initial experience with the use of IV sotalol in the pediatric population. METHODS: A retrospective study of all pediatric patients receiving IV sotalol was performed...
July 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29991362/trends-in-prescription-of-cardiovascular-drugs-to-children-in-relation-to-prevalence-of-chd-from-1999-to-2016
#8
Christian B Poulsen, Mads Damkjær
IntroductionOwing to massive improvements in the diagnostics and surgery of children with CHD, fatality has decreased substantially. As more children with CHD survive from infancy into later childhood, more will need medication for chronic heart failure. However, surprisingly little is actually known about which drugs are being used to treat children with CHD, and whether prescription rates and CHD prevalence have changed over time. OBJECTIVE: The objective of this study was to assess the total prescription of cardiovascular drugs to children during an 18-year period and to assess concomitant CHD prevalence...
July 11, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29988296/long-term-risk-of-recurrent-atrial-fibrillation-and-ischemic-stroke-after-post-operative-atrial-fibrillation-complicating-cardiac-and-non-cardiac-surgeries
#9
Karam Ayoub, Fuad Habash, Ahmed Almomani, Jack Xu, Meera Marji, Allison Shaw-Devine, Hakan Paydak, Srikanth Vallurupalli
Background: New onset post-operative atrial fibrillation (POAF) can complicate both non-cardiac(NCS) and cardiac(CS) surgeries. Long term differences in recurrence of atrial fibrillation (AF) and incidence of ischemic stroke/transient ischemic attack(CVA)between these types of POAFare lacking. Objective: To compare thelong term recurrence rate of AF and incidence of CVAin patients withnew onset POAF after CS and NCS. Methods: All patients who developed POAF between May 2010 and April 2014 were included in this single-center, retrospective study Exclusion criteria included a prior history of atrial tachyarrhythmias and pre-operative use of anti-arrhythmic drugs...
April 2018: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29972578/atrial-fibrillation-in-acute-chagas-disease-acquired-via-oral-transmission-a-case-report
#10
Paulo Fernando Pimenta de Souza, Rosane Cheble Domingues Pine, Francisco Lúzio de Paula Ramos, Ana Yecê das Neves Pinto
Atrial fibrillation (AF), a type of supraventricular arrhythmia increases the risk of thromboembolism. Chagas disease has been reported in the Brazilian Amazon region over approximately 20 years. Cardiac abnormalities are recorded in at least 50% of patients and among these, 3.3% develop AF. We describe a case of a 41-year-old man from Muaná, Pará State, who reported a 30-day history of a febrile illness. Acute Chagas disease was confirmed, and an electrocardiogram revealed AF. He was treated with antiparasitic and anti-arrhythmic drugs, beta blockers, and anticoagulants...
May 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29961465/post-truth-era-and-cardiology-after-orbita-before-cabana
#11
EDITORIAL
Ozcan Ozeke, Serkan Cay, Firat Ozcan, Serkan Topaloglu, Dursun Aras
The evidence-based medicine is rooted in the scientific truth. Oxford Dictionaries has released its 2016 word of the year: "Post-truth," which they define as "relating to or denoting circumstances in which objective facts are less influential in shaping public opinion than appeals to emotion and personal belief". In everything from climate change denial to the anti-vaccine movement, we're seeing the consequences of a failure to engage with scientific evidence. Fake news and post-truth pronouncements are increasingly common in social media and political era and are unfortunately also progressively being applied to the medical science...
May 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29955856/katp-channel-blockade-as-a-novel-anti-arrhythmic-strategy-evolving-from-tachy-to-brady-therapy
#12
Talha A Farid, Abhishek Baskaran, Kumaraswamy Nanthakumar
No abstract text is available yet for this article.
June 27, 2018: Endocrinology
https://www.readbyqxmd.com/read/29948588/novel-use-of-a-3-dimensional-mapping-system-in-cryoablation-of-right-sided-and-septal-accessory-pathways-playback-ablation
#13
Yuki Ishidoya, Akihiko Yotsukura, Fumihiko Sano, George Suzuki, Tadafumi Nanbu, Izumi Yoshida, Masayuki Sakurai
PURPOSE: Despite recent advances in the treatment of eliminating accessory pathways (APs), catheter-induced mechanical block (bump) of APs has been reported to result in a less favorable outcome with high primary failure and recurrence rates. The real bump site cannot always be precisely reapproached under fluoroscopy so physicians can perform ablation to a location different from where the mechanical block was encountered. In this paper, we describe this novel use of a 3-dimensional (3D) mapping system (playback ablation) with a case series...
June 14, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29948585/evaluation-of-right-ventricular-pacing-parameters-in-patients-with-proliferative-scar
#14
Veysel Kutay Vurgun, Emir Baskovski, Huseyin Goksuluk, Nil Ozyuncu, Turkan Seda Tan, Ali Timucin Altin, Basar Candemir, Omer Akyurek
BACKGROUND: Dermal and myocardial injury results in a healing process, characterized by inflammation and fibrosis. We aimed to investigate association between proliferative scarring at the operation site and right ventricular (RV) pacing and sensing parameters, two clinical outcomes associated with impaired dermal and myocardial healing, respectively. METHODS: We performed an observational retrospective study among regularly followed pacemaker (PM)/implantable cardioverter defibrillator (ICD)-implanted patients at our medical center...
June 13, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29945712/-is-it-worth-delivering-direct-current-counter-shock-to-critically-ill-patients-with-supra-ventricular-tachyarrhythmia
#15
S Champion, B A Gaüzère, D Vandroux, Y Lefort
Supra-ventricular tachyarrhythmia and its treatment have been poorly investigated in ICU patients. AIMS: To evaluate efficacy and safety of cardioversion for supra-ventricular tachyarrhythmia in the intensive care unit (ICU). PATIENTS AND METHODS: Prospective inclusion of all patients who presented supra-ventricular tachyarrhythmias lasting≥30seconds in a single medico-surgical ICU, except cardiac surgery. Anti-arrhythmic drugs and/or direct-current cardioversion were administered on a liberal basis...
June 23, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29931291/differential-regulation-of-sodium-channels-as-a-novel-proarrhythmic-mechanism-in-the-human-failing-heart
#16
Nataliya Dybkova, Shakil Ahmad, Steffen Pabel, Petros Tirilomis, Nico Hartmann, Thomas H Fischer, Philipp Bengel, Theodoros Tirilomis, Senka Ljubojevic, André Renner, Jan Gummert, David Ellenberger, Stefan Wagner, Norbert Frey, Lars S Maier, Katrin Streckfuss-Boemeke, Gerd Hasenfuss, Samuel Sossalla
Aims: In heart failure, enhanced persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. However, the underlying regulatory mechanisms remain unclear. Our aim was to potentially investigate the regulation and electrophysiological contribution of neuronal sodium channel Nav1.8 in failing human heart and eventually to reveal a novel anti-arrhythmic therapy. Methods and Results: By Western blot, we found that Nav1...
June 20, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29929349/neuropathic-cancer-pain-prevalence-pathophysiology-and-management
#17
So Young Yoon, Jeeyoung Oh
Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. The clinical characteristics of NCP differ from those of nociceptive pain in terms of both the hypersensitivity symptoms (burning, tingling, and an electrical sensation) and the hyposensitivity symptoms (numbness and muscle weakness)...
June 25, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29926671/-anti-arrhythmic-effects-of-taurine-magnesium-coordination-compound-on-torsades-de-pointes
#18
Yan Li, Kai Sun, Meng-Yao An, Ying-Ying Pan, Tao Sun, Yong-Qiang Yin, Yi Kang, Jian-Shi Lou
OBJECTIVES: To investigate the effect of taurine magnesium coordination compound (TMCC) on torsades de pointes (TdP) in isolated guinea pig hearts. METHODS: Healthy male guinea pigs weighting 250~300 g were randomly divided into 4 groups:①TdP model group ( n =7):Isolated hearts were perfused by normal K-H solution 20 minutes, then perfused by slowly activated delayed rectifier potassium current(IKs) blocker 10 μ mol/L Chromanol 293B under hypokalemic solution(1...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29899727/flecainide-induced-brugada-syndrome-in-a-patient-with-skeletal-muscle-sodium-channelopathy-a-case-report-with-critical-therapeutical-implications-and-review-of-the-literature
#19
Michele Cavalli, Barbara Fossati, Raffaele Vitale, Elisa Brigonzi, Vito A G Ricigliano, Lorenzo Saraceno, Rosanna Cardani, Carlo Pappone, Giovanni Meola
Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29898849/intentional-and-unintentional-medication-non-adherence-in-african-americans-insights-from-the-jackson-heart-study
#20
Robert J Mentz, Melissa A Greiner, Paul Muntner, Daichi Shimbo, Mario Sims, Tanya M Spruill, Benjamin F Banahan, Wei Wang, Stanford Mwasongwe, Karen Winters, Adolfo Correa, Lesley H Curtis, Emily C O'Brien
BACKGROUND: Non-adherence to medications is common and leads to suboptimal outcomes. Non-adherence can be intentional (e.g., deciding to skip dosages) or unintentional (e.g., forgetting), yet few studies have distinguished these reasons. An improved understanding of the reasons for non-adherence could inform the development of effective interventions. METHODS AND RESULTS: We analyzed data from African Americans in the Jackson Heart Study who were prescribed medications for one or more chronic conditions...
June 2018: American Heart Journal
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