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Breast cancer

Pham Thi Thu Phuong, Sungin Lee, Changkyu Lee, Bohyung Seo, Sanghyun Park, Kyung Taek Oh, Eun Seong Lee, Han-Gon Choi, Beom Soo Shin, Yu Seok Youn
Chlorin e6 (Ce6) has attracted considerable interest as a promising second-generation photosensitizer for photodynamic therapy (PDT). However, the in vivo availability of Ce6 is significantly restricted by its low water solubility and poor ability to target tumors. We sought to overcome the limitations of Ce6 by using albumin nanoparticles with nab™ (nanoparticle albumin-bound) technology. The fabricated albumin nanoparticles consisted of bovine serum albumin (BSA), Ce6-BSA, and beta-carotene as a carrier, photosensitizing agent, and cross-linker, respectively...
July 10, 2018: Colloids and Surfaces. B, Biointerfaces
Islam Zaki, Mohammed K Abdelhameid, Ibrahim M El-Deen, Abdel Hady A Abdel Wahab, Abeer M Ashmawy, Khaled O Mohamed
Some triazinone derivatives are designed and synthesized as potential antitumor agents. Triazinone derivatives 4c, 5e and 7c show potent anticancer activity over MCF-7 breast cancer cells higher than podophyllotoxin (podo) by approximate 6-fold. DNA flow cytometry analysis for the compounds 3c, 4c, 5e, 6c and 7c show a potent inhibitory activity of cell proliferation and cell cycle arrest at G2 /M phase. Compounds 4c, 5e and 7c exhibit low to moderate β-tubulin polymerization inhibition percentage. Meanwhile, compound 6c displayed excellent β-tubulin percentage of polymerization inhibition equivalent to that exhibited by podo...
July 7, 2018: European Journal of Medicinal Chemistry
Michał Antoszczak, Alicja Urbaniak, Magdalena Delgado, Ewa Maj, Björn Borgström, Joanna Wietrzyk, Adam Huczyński, Youzhong Yuan, Timothy C Chambers, Daniel Strand
The polyether ionophore salinomycin has recently captured much interest due to its potent activity against multi-drug resistant cancer cells and cancer stem cells. Previous studies have shown that either acylation of the C20 position or esterification/amidation of the C1 carboxylate moiety is beneficial in terms of biological properties. In this paper, we present the first analogs combining such modifications. Evaluation of the anti-proliferative activity against a series of cancer cell lines showed that acylation of the C20 hydroxyl group improves the activity of salinomycin C1 amides but not of the corresponding C1 esters...
July 10, 2018: European Journal of Medicinal Chemistry
Nada M Ghanem, Faten Farouk, Riham F George, Safinaz E S Abbas, Ossama M El-Badry
New imidazo[4,5-b]pyridine derivatives were designed, synthesized and screened for their anticancer activity against breast (MCF-7) and colon (HCT116) cancer cell lines. Nine compounds (I, II, IIIa, IIIb, IV, VI, VIIa, VIII, IX) showed significant activity against MCF-7, while six compounds (I, VIIc, VIIe, VIIf, VIII, IX) elicited a remarkable activity against HCT116. Compounds showing significant anticancer activity revealed remarkable CDK9 inhibitory potential (IC50  = 0.63-1.32 μM) relative to sorafenib (IC50  = 0...
July 6, 2018: Bioorganic Chemistry
Maia Thrift-Perry, Anna Cabanes, Fatima Cardoso, Katherine Moose Hunt, Tauane Araújo Cruz, Kyra Faircloth
Metastatic breast cancer (mBC) is an area with high unmet need across the world. Despite significant progress to meet patient need, current breast cancer (BC) policies fail to recognize the unique challenges of patients who are further along the cancer patient journey. This analysis aims to understand BC/mBC policy development at a global level and identify opportunities for further development. A comprehensive analysis of National Cancer Control Plans (NCCPs) policies and programs was conducted across 16 countries, which represent a diverse range of healthcare systems, economies and geographic regions...
June 18, 2018: Breast: Official Journal of the European Society of Mastology
Samira Yadamani, Ali Neamati, Masoud Homayouni-Tabrizi, S Ali Beyramabadi, Soheyla Yadamani, Azar Gharib, Ali Morsali, Maryam Khashi
The breast cancer is the most common type of cancer in women. In this project, the breast cancer was transplanted in vivo with the TUBO cells. Then, the cancerous mice were treated by radiation of low frequency electromagnetic fields and injection of the Mn(II) complex of the N,N'-dipyridoxyl(1,2-diaminobenzene) Schiff base. Three different concentrations of the Mn(II) complex were used. Cytotoxicity and morphological alterations caused by the Mn(II) complex in the TUBO breast cancer cell line have been evaluated...
July 11, 2018: Breast: Official Journal of the European Society of Mastology
Federica Alessandrini, Laura Pezzè, Daniel Menendez, Michael A Resnick, Yari Ciribilli
Breast cancer treatment often includes Doxorubicin as adjuvant as well as neoadjuvant chemotherapy. Despite its cytotoxicity, cells can develop drug resistance to Doxorubicin. Uncovering pathways and mechanisms involved in drug resistance is an urgent and critical aim for breast cancer research oriented to improve treatment efficacy. Here we show that Doxorubicin and other chemotherapeutic drugs induce the expression of ETV7, a transcriptional repressor member of ETS family of transcription factors. The ETV7 expression led to DNAJC15 down-regulation, a co-chaperone protein whose low expression was previously associated with drug resistance in breast and ovarian cancer...
July 16, 2018: Neoplasia: An International Journal for Oncology Research
Song Xue, Xiaolei Gu, Jian Zhang, Huanli Sun, Chao Deng, Zhiyuan Zhong
Polypeptide micelles though having been proved to be an appealing nanoplatform for cancer chemotherapy are met with issues like inefficient drug encapsulation, gradual drug release, and/or low tumor cell selectivity and uptake. Here, we report on cRGD-decorated, small-sized, robust and reduction-responsive polytyrosine micelles (cRGD-rPTM) based on poly(ethylene glycol)-b-poly(L-tyrosine)-lipoic acid (PEG-b-PTyr-LA) conjugate for high loading and targeted delivery of doxorubicin (Dox). Notably, cRGD-rPTM exhibited efficient loading of Dox, giving cRGD-rPTM-Dox with a drug loading content (DLC) of 18...
July 19, 2018: Biomacromolecules
Hari Setyowibowo, Fredrick Dermawan Purba, Joke A M Hunfeld, Aulia Iskandarsyah, Sawitri S Sadarjoen, Jan Passchier, Marit Sijbrandij
OBJECTIVES: Breast cancer (BC) is prevalent in low and middle-income countries (LMICs) where the majority of cases are diagnosed in late stages. The aims of this study were: (1) to assess quality of life (QOL) and health status of Indonesian women with BC symptoms before definitive diagnosis; (2) to compare QOL and health status between women with BC symptoms before definitive diagnosis and Indonesian women in general; (3) to evaluate the association between demographic variables (age, residence, social economic status and education level) and QOL within the Indonesian women with BC symptoms before definitive diagnosis...
2018: PloS One
Cheol Keun Park, Douglas P Malinowski, Nam Hoon Cho
This study was conducted to develop a novel algorithm for determining the origin of tumors by combining analysis of cluster patterns with immunocytochemistry (ICC) for markers in cells from fine-needle aspirates of ascites. We used LBC, based on SurePathTM (BD Diagnostics) technology, to screen 96 peritoneal fluid samples from patients with known malignancies and from 10 control patients with cirrhosis. Following dual ICC staining for cytokeratin 7 (CK7) and paired box gene 8 (PAX8), we developed an algorithm using immunoreactivity and three-dimensional (3D) cluster patterns to correlate staining and 3D cluster patterns with common primary origins that included stomach, ovarian, pancreatobiliary tract, colon, lung, and breast cancers...
2018: PloS One
H-F Li, Q Xie, Q-W Nie, X Ye
OBJECTIVE: To determine whether prostate-specific antigen (PSA) could serve as a biomarker for breast cancer. MATERIALS AND METHODS: We performed an electronic search on Medline, PubMed, SPRINGER, John Wiley, Science Direct, EBSCO, CNKI and Wanfang Data to identify relevant studies for our meta-analysis. The search terms included ['prostate specific antigen' or 'PSA' (MESH)] and ['breast cancer' or 'breast carcinoma' (MESH)]. RESULTS: A comprehensive meta-analysis of 10 studies comprising of 770 cases and 799 controls were included...
July 2018: European Review for Medical and Pharmacological Sciences
Huifen Ye, Junshao Zeng, Wenzhou Qin, Zhao Yang, Ling Yang, Zhitong Wu, Guinian Du
RATIONALE: Rapidly growing mycobacteria (RGM) are well-known causative agents of human infections, particularly in immunocompromised hosts. However, Mycobacterium fortuitum, a predominant organism, in catheter-associated infections, has rarely been documented in totally implantable venous access port (TVIAP)-associated bloodstream infections. PATIENT CONCERNS: A 25-year-old woman with breast cancer presented to hospital with repeated fever for several days. The patient first refused to remove the TVIAP in her body, and had a relapse of M...
July 2018: Medicine (Baltimore)
Li Gu, Chang Cao, Jing Fu, Qian Li, De-Hua Li, Ming-Yao Chen
BACKGROUND: Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent. METHOD: A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size. RESULTS: Finally, 31 eligible studies were included in this meta-analysis...
July 2018: Medicine (Baltimore)
Fay Wright, Laura B Dunn, Steven M Paul, Yvette P Conley, Jon D Levine, Marilyn J Hammer, Bruce A Cooper, Christine Miaskowski, Kord M Kober
BACKGROUND: Morning fatigue is a distinct symptom experienced during chemotherapy that demonstrates significant interindividual variability. OBJECTIVES: The aims of this study were to identify subgroups with distinct morning fatigue profiles and evaluate how these subgroups differed by demographic, clinical, and symptom characteristics. METHODS: Outpatients (N = 1332) with breast, gastrointestinal, gynecological, or lung cancer completed questionnaires 6 times over 2 cycles of chemotherapy...
July 17, 2018: Cancer Nursing
Laura D Scherer, K D Valentine, Niraj Patel, S Glenn Baker, Angela Fagerlin
Research that has explored public enthusiasm for cancer screening has suggested that the public may be overly enthusiastic about being screened with certain tests, and this has been attributed, in part, to lack of knowledge about the risks and benefits. In this article the authors considered the possibility that some people may be enthusiastic about screening even when they are informed and also accept that the test unquestionably does not save lives. Two studies were conducted, one that involved a nationally representative U...
July 19, 2018: Journal of Experimental Psychology. Applied
Abdullah Durhan, Gamze Durhan, Aydan Eroğlu
The neutrophil-to-lymphocyte ratio is clinically accepted as a marker of systemic inflammatory response. In breast cancer patients, neutrophil-to-lymphocyte ratio can be used as an important prognostic indicator of survival. In routine laboratory tests, the platelet-to-lymphocyte ratio can also be examined in addition to neutrophil-to-lymphocyte ratio. Although the effects on breast cancer survival of platelet-to-lymphocyte ratio, which is accepted as the twin of neutrophil-to-lymphocyte ratio, are not as widely accepted as those of neutrophil-to-lymphocyte ratio, platelet activation is known to be a feature of cancer...
2018: Turkish Journal of Surgery
Arnab Biswas, Sujay Mukhopadhyay, Roop Shikha Singh, Ashish Kumar, Nishant Kumar Rana, Biplob Koch, Daya Shankar Pandey
Manipulating gelation properties of the isomeric zinc-terpyridine complexes C-1 (nongelator) and C-2 (gelator) using three different luminescent dyes, viz., acridine yellow (AY), ethidium bromide (EB), and azido-boron dipyrromethene, have been described. Hybrid gels created by the combination of C-1, C-2, and above-mentioned dyes have been termed complex-luminogen mixed gels (CLMGs). Ensuing CLMGs have been thoroughly characterized by spectral, morphological, and rheological studies. Cytotoxicity measurements and imaging against breast cancer cell line MDA-MB-231 unveiled that three out of the five CLMGs can be effectively used for cell imaging...
May 31, 2018: ACS Omega
Daniele Merli, Antonella Profumo, Nora Bloise, Giulia Risi, Stefano Momentè, Lucia Cucca, Livia Visai
In this study, we aimed to investigate in vitro whether the synthetized indium maltolate (InMal) and gallium maltolate (GaMal) could exert either a toxic effect toward breast cancer cell line MDA-MB-231 or an agonistic activity with mitoxantrone (MTX) in comparison to fibroblast cell line NIH-3T3. Both GaMal and InMal reduced viability of MDA-MB-231, and at a lesser extent of NIH3-T3, in a dose- and time-dependent mode, the outcome was more effective in comparison to MTX sole exposure. Both GaMal and InMal toxicity was reverted by iron citrate addition on NIH3-T3, not on MDA-MB-231, showing indirectly that gallium and indium's mechanisms of action may include iron targeting...
April 30, 2018: ACS Omega
Anuj Kumar, Afsana Naaz, A P Prakasham, Manoj Kumar Gangwar, Raymond J Butcher, Dulal Panda, Prasenjit Ghosh
Five enantiomeric pairs of palladium complexes of 1,2,4-triazole-derived chiral N-heterocyclic carbene ligands were investigated to probe the influence of chirality on the compound's anticancer activity. Although no chirality-related influence was observed for any of the enantiomeric pair, strong anticancer activity was seen for a particular pair, (1 S ,2 S ,5 R )- 1c and (1 R ,2 R ,5 S )- 1c , which was significantly more active than the benchmark drug cisplatin for human breast cancer cells, MCF-7 (ca. 24-27-fold), and human cervical cancer cells, HeLa (ca...
August 31, 2017: ACS Omega
Jyotsna Bhat, Soma Mondal, Pallabi Sengupta, Subhrangsu Chatterjee
Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich segment of nuclease hypersensitive element (NHE III1 ), that is, " Pu27 ", which is localized in the promoter region. Ligand-induced stabilization of the Pu27 structure has been identified as a novel target for cancer therapeutics. Here, we have explored the library of synthetic compounds against the predefined binding site of Pu27 . Three compounds were selected based on the docking analyses; they were further scrutinized using all atom molecular dynamics simulations in an explicit water model...
August 31, 2017: ACS Omega
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