Read by QxMD icon Read

denervated exercise

Elisa Giorgetti, Zhigang Yu, Jason P Chua, Ryosuke Shimamura, Lili Zhao, Fan Zhu, Sriram Venneti, Maria Pennuto, Yuanfang Guan, Gene Hung, Andrew P Lieberman
Spinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder, is caused by a CAG/glutamine expansion in the androgen receptor (polyQ AR). Recent studies demonstrate that skeletal muscle is an important site of toxicity that contributes to the SBMA phenotype. Here, we sought to identify critical pathways altered in muscle that underlie disease manifestations in AR113Q mice. This led to the unanticipated identification of gene expression changes affecting regulators of carbohydrate metabolism, similar to those triggered by denervation...
September 27, 2016: Cell Reports
Sana Salah, Houda Migaou, Zied Belaaj, Soumaya Boudokhane, Anis Jellad, Abderrazak Abid, Zohra Ben Salah Frih
OBJECTIVE: Winging of the scapula has a variety of causes and a variable prognosis. It contributes to a disruption of the scapulohumeral rhythm with a decreased flexion and abduction of the upper extremity and a source of a considerable pain. This condition can affect the ability to perform activities of daily living. The most common cause of scapula winging is serratus anterior paralysis resulting from a lesion of the long thoracic nerve. The rupture of the muscle itself remains uncommon...
September 2016: Annals of Physical and Rehabilitation Medicine
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Kyle Edmunds, Íris Dröfn Árnadóttir, Sandra Zampieri, Barbara Ravara, Francesco Gava, Alessandra Nori, Valerio Gobbo, Stefano Masiero, Andrea Marcante, Alfonc Baba, Francesco Piccione, Sheila Schils, Amber Pond, Simone Mosole
Many factors contribute to the decline of skeletal muscle that occurs as we age. This is a reality that we may combat, but not prevent because it is written into our genome. The series of records from World Master Athletes reveals that skeletal muscle power begins to decline at the age of 30 years and continues, almost linearly, to zero at the age of 110 years. Here we discuss evidence that denervation contributes to the atrophy and slowness of aged muscle. We compared muscle from lifelong active seniors to that of sedentary elderly people and found that the sportsmen have more muscle bulk and slow fiber type groupings, providing evidence that physical activity maintains slow motoneurons which reinnervate muscle fibers...
September 3, 2016: Aging Clinical and Experimental Research
Emmanuel G Ciolac, Rafael E Castro, José M Rodrigues da Silva, Edimar A Bocchi, Guilherme V Guimarães
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Delin Ma, Jeffrey M Shuler, Aishwarya Kumar, Quincy R Stanford, Sudheer Tungtur, Hiroshi Nishimune, John A Stanford
Background The use of exercise in amyotrophic lateral sclerosis (ALS) is controversial. Although moderate exercise appears to be beneficial for limb muscles in ALS, the effects of exercise on bulbar muscles such as the tongue have not been studied. Objective To determine the effects of tongue force training on bulbar motor function in the SOD1-G93A rat model of ALS. Methods We compared the effects of tongue force training on bulbar motor function and neuromuscular junction innervation in female SOD1-G93A rats and age-matched female wild-type controls...
August 28, 2016: Neurorehabilitation and Neural Repair
Charline Dambreville, Jérémie Charest, Yann Thibaudier, Marie-France Hurteau, Victoria Kuczynski, Guillaume Grenier, Alain Frigon
Complete spinal cord injury (SCI) alters the contractile properties of skeletal muscle, and although exercise can induce positive changes, it is unclear whether the remaining motor system can produce adaptive muscle plasticity in response to a subsequent peripheral nerve injury. To address this, the nerve supplying the lateral gastrocnemius (LG) and soleus muscles was sectioned unilaterally in four cats that had recovered hindlimb locomotion after spinal transection. In these spinal cats, kinematics and electromyography (EMG) were collected before and for 8 wk after denervation...
September 1, 2016: Journal of Neurophysiology
T C Yu, A Py Liu, K S Lun, B Hy Chung, T C Yung
OBJECTIVE: To report our experience in the management of catecholaminergic polymorphic ventricular tachycardia in Hong Kong Chinese children. METHODS: This case series study was conducted in a tertiary paediatric cardiology centre in Hong Kong. All paediatric patients diagnosed at our centre with catecholaminergic polymorphic ventricular tachycardia from January 2008 to October 2014 were included. RESULTS: Ten patients (five females and five males) were identified...
August 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Roland W J Hangelbroek, Parastoo Fazelzadeh, Michael Tieland, Mark V Boekschoten, Guido J E J Hooiveld, John P M van Duynhoven, James A Timmons, Lex B Verdijk, Lisette C P G M de Groot, Luc J C van Loon, Michael Müller
BACKGROUND: The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre-)frail older adults. Additionally, we examine the effect of resistance-type exercise training on the muscle transcriptome in healthy older subjects and (pre-)frail older adults. METHODS: Baseline transcriptome profiles were measured in muscle biopsies collected from 53 young, 73 healthy older subjects, and 61 frail older subjects...
February 2, 2016: Journal of Cachexia, Sarcopenia and Muscle
Manuela J Scherer, Gerhard Weinreich, Bjoern E Kleibrink, Thomas Rabis, Markus Kamler, Helmut Teschler, Urte Sommerwerck
PURPOSE: Bilateral lung transplantation results in complete denervation of the lung and might impair hypercapnic ventilatory response (HCVR). However, experimental and clinical findings are scarce and conflicting. Therefore, this study investigated the relationship between HCVR and exercise capacity after long-term bilateral lung transplantation. METHODS: This cross-sectional analysis enrolled 46 bilateral lung transplant recipients between October 2011 and July 2012 who underwent cardiopulmonary exercise testing to evaluate maximum workload, and carbon dioxide (CO2) rebreathing...
August 2016: Lung
Lucas P Santos, Ruy S Moraes, Paulo J C Vieira, Garrett I Ash, Gustavo Waclawovsky, Linda S Pescatello, Daniel Umpierre
BACKGROUND: Resistant hypertension often exposes patients to poor blood pressure (BP) control, resulting in clinical vulnerability, possible need for device-based procedures (denervation) and increased therapy costs. Regular exercise markedly benefits patients with hypertension, including resistant patients. However, little is known about short-term exercise effects in resistant hypertension. OBJECTIVE: To evaluate acute hemodynamic effects of exercise in resistant hypertension...
July 2016: Journal of Hypertension
Niamh McCarty, Barry Silverman
Cardiovascular autonomic neuropathy often goes unrecognized. We present a case of a 22-year-old man with multiple manifestations of this disease, including weakness, dizziness, fatigue, tachycardia, abnormal QTc, and orthostasis, which occurred 2 years after his type 1 diabetes diagnosis. He exhibited parasympathetic denervation with resting tachycardia and exercise intolerance but also had evidence of orthostatic hypotension, which suggests sympathetic denervation. He did not have complete cardiovascular autonomic reflex testing, which would have been helpful, but improved with aggressive diabetes treatment and the increase of beta-blockade...
April 2016: Proceedings of the Baylor University Medical Center
Jin Zhou, Bin Liu, Chun Liang, Yangxin Li, Yao-Hua Song
Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor necrosis factor α (TNF-α) is involved in mediating the wasting effect. To date, a causal relationship between TNF-α signaling and muscle wasting has been established in animal models. However, results from clinical trials are conflicting. This is partly due to the fact that other factors such as TNF-like weak inducer of apoptosis (TWEAK) and interleukin 6 (IL-6) are also involved in skeletal muscle wasting...
May 2016: Trends in Endocrinology and Metabolism: TEM
Hitesh C Patel, Stuart D Rosen, Carl Hayward, Vassilios Vassiliou, Gillian C Smith, Ricardo R Wage, James Bailey, Ronak Rajani, Alistair C Lindsay, Dudley J Pennell, S Richard Underwood, Sanjay K Prasad, Raad Mohiaddin, J Simon R Gibbs, Alexander R Lyon, Carlo Di Mario
AIM: Heart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RDT) might be helpful and there are no data currently in humans with HFpEF. METHODS AND RESULTS: In this single-centre, randomized, open-controlled study we included 25 patients with HFpEF [preserved left ventricular (LV) ejection fraction, left atrial (LA) dilatation or LV hypertrophy and raised B-type natriuretic peptide (BNP) or echocardiographic assessment of filling pressures]...
June 2016: European Journal of Heart Failure
Gareth L Ackland, John Whittle, Andrew Toner, Asif Machhada, Ana Gutierrez Del Arroyo, Alberto Sciuso, Nicholas Jenkins, Alex Dyson, Richard Struthers, J Robert Sneyd, Gary Minto, Mervyn Singer, Ajay M Shah, Alexander V Gourine
OBJECTIVES: Molecular mechanisms linking autonomic dysfunction with poorer clinical outcomes in critical illness remain unclear. We hypothesized that baroreflex dysfunction alone is sufficient to cause cardiac impairment through neurohormonal activation of (nicotinamide adenine dinucleotide phosphate oxidase dependent) oxidative stress resulting in increased expression of G-protein-coupled receptor kinase 2, a key negative regulator of cardiac function. DESIGN: Laboratory/clinical investigations...
August 2016: Critical Care Medicine
Jacopo F Imberti, Katherine Underwood, Andrea Mazzanti, Silvia G Priori
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inheritable cardiac disorder associated with exercise- and stress-induced sudden death in young individuals. Although important steps forward have been made in the comprehension and treatment of this disease, several aspects remain unclear. Firstly, from an epidemiological standpoint the actual prevalence of CPVT is still unknown and possibly underestimated. In addition, the diagnostic process remains very challenging and can be supported by genetic analysis in only about half of the cases...
August 2016: Heart, Lung & Circulation
A Vidal Esteban, D Natera-de Benito, D Martínez Sánchez, A Reche Sainz, M R Rodríguez Díaz, C M Alfaro Iznaola, M T de Santos Moreno
UNLABELLED: Harlequin syndrome (HS) is a rare autonomic disorder due to a hemifacial cutaneous sympathetic denervation. It is characterized by unilateral diminished sweating and flushing of the face even though after heat or prolonged exercise. It is typically acquired. Congenital cases only represent a 6% of all individuals with HS. All congenital HS cases reported so far showed a concomitant Horner syndrome, probably due to a stellate ganglion involvement. HS represents an uncommon autonomic disorder due to a hemifacial cutaneous sympathetic denervation...
May 2016: European Journal of Paediatric Neurology: EJPN
Shuang Qiu, Saeed Alzhab, Glen Picard, J Andrew Taylor
PURPOSE: In the able-bodied, exercise training results in increased ventilatory capacity to meet increased aerobic demands of trained skeletal muscle. However, after spinal cord injury (SCI), peak ventilation can be limited by pulmonary muscle denervation. In fact, peak ventilation may restrict aerobic capacity in direct relation to injury level. Hybrid functional electrical stimulation (FES) exercise training results in increased aerobic capacity and dissociation between aerobic capacity and injury level in those with injuries at T3 and below...
June 2016: Medicine and Science in Sports and Exercise
Karl Fengler, Diana Heinemann, Thomas Okon, Karoline Röhnert, Thomas Stiermaier, Maximilian von Röder, Christian Besler, Ulrike Müller, Robert Höllriegel, Gerhard Schuler, Steffen Desch, Philipp Lurz
INTRODUCTION: Despite the ongoing debate on the role of renal sympathetic denervation (RSD) in the management of therapy-resistant hypertension, little is known about its possible effects on exercise blood pressure (BP), a known predictor for future cardiovascular events. We sought to evaluate the effect of RSD on exercise BP in a randomized, sham-controlled trial in patients with mild hypertension. METHODS AND RESULTS: Patients with therapy-resistant mild hypertension (defined by mean daytime systolic BP between 135 and 149 mmHg or mean daytime diastolic BP between 90 and 94 mmHg on 24-h ambulatory BP measurement) were randomized to either radiofrequency-based RSD or a sham procedure...
July 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"