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https://www.readbyqxmd.com/read/29906628/sleep-disorders-in-children-with-incidental-pineal-cyst-on-mri-a-pilot-study
#1
Lourdes M DelRosso, Kenneth Martin, Oliviero Bruni, Raffaele Ferri
INTRODUCTION: For several years, pineal cysts have been considered an incidental finding on brain MRI's even though research and case reports have shown a possible association of pineal cysts with headaches and sleep disturbances. This pilot study aims to evaluate sleep disorders in school-age children with an incidental pineal cyst in an otherwise normal brain MRI. METHOD: Children aged 6-12 years, who were referred for evaluation of headaches, tics, or syncope, and had an incidental pineal cyst on an otherwise normal brain MRI were included and compared to a control group of children with the same referral reasons but with a normal MRI and to a cohort of normal controls...
May 16, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29906291/a-real-time-medical-cartography-of-epidemic-disease-nodding-syndrome-using-village-based-lay-mhealth-reporters
#2
Raquel Valdes Angues, Austen Suits, Valerie S Palmer, Caesar Okot, Robert A Okot, Concy Atonywalo, Suzanne K Gazda, David L Kitara, Moka Lantum, Spencer S Peter
BACKGROUND: Disease surveillance in rural regions of many countries is poor, such that prolonged delays (months) may intervene between appearance of disease and its recognition by public health authorities. For infectious disorders, delayed recognition and intervention enables uncontrolled disease spread. We tested the feasibility in northern Uganda of developing real-time, village-based health surveillance of an epidemic of Nodding syndrome (NS) using software-programmed smartphones operated by minimally trained lay mHealth reporters...
June 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29905157/idiopathic-generalised-epilepsies-of-adult-onset-a-reappraisal-and-literature-review
#3
José Pimentel, Sara Varanda, Pedro Guimarães, Fernando Lopes da Silva
Idiopathic generalised epilepsies are characterised by widespread, symmetric, bilateral spike-and-wave discharges on EEG. Onset typically occurs in children and adolescents, but may also start in adulthood. These forms of adult onset constitute the focus of this review. A critical analysis of the medical literature was conducted through a narrative review search of PubMed and Medline databases. Cases of idiopathic generalised epilepsies with adult onset, in general, are not considered to be independent nosological entities...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29905152/epileptic-seizure-semiology-in-different-age-groups
#4
Guadalupe Fernandez-Baca Vaca, Carlos L Mayor, Naira García Losarcos, Jun T Park, Hans O Lüders
Seizure semiology provides information about the eloquent cortex involved during a seizure and helps to generate a hypothesis regarding the localization of the epileptogenic zone (EZ), a prerequisite for surgical management of epilepsy. We aimed to study the seizure semiology among all different age groups to better characterize semiological changes that occur with age. We performed a retrospective review of video-EEG data in paediatric and adult patients admitted to the Epilepsy Monitoring Unit over a three-year period...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29901816/effect-of-modified-atkins-diet-in-adults-with-drug-resistant-focal-epilepsy-a-randomized-clinical-trial
#5
Magnhild Kverneland, Ellen Molteberg, Per O Iversen, Marit B Veierød, Erik Taubøll, Kaja K Selmer, Karl O Nakken
OBJECTIVE: Ketogenic diets reduce seizures in children with drug-resistant epilepsy. Whether adults benefit from similar treatment has not been clarified. We therefore examined the efficacy of the modified Atkins diet in adults with drug-resistant focal epilepsy. METHODS: We performed a randomized clinical trial (RCT) with patients >16 years who had at least 3 seizures per month despite having tried at least 3 antiepileptic drugs. They were randomized to either 12 weeks on the modified Atkins diet (diet group) or habitual diet (control group)...
June 14, 2018: Epilepsia
https://www.readbyqxmd.com/read/29901235/long-term-negative-impact-of-an-inappropriate-first-antiepileptic-medication-on-the-efficacy-of-a-second-antiepileptic-medication-in-mice
#6
Jodi L Pawluski, Mathieu Kuchenbuch, Sarah Hadjadj, Gabriel Dieuset, Nathalie Costet, Laurent Vercueil, Arnaud Biraben, Benoît Martin
Childhood absence epilepsy (CAE) is one of the most frequent epilepsies in infancy. The first-line recommended therapy for CAE is based on the prescription of the narrow-spectrum ethosuximide and the broad-spectrum valproic acid, which have similar efficacy in the first 12 months. Nevertheless, some antiepileptic drugs (AEDs) may worsen seizure duration and type in this syndrome. In line with this, we have encountered a case of identical twins with CAE and early exposure to different antiseizure drugs leading to divergent outcomes...
June 14, 2018: Epilepsia
https://www.readbyqxmd.com/read/29899785/association-between-posterior-reversible-encephalopathy-syndrome-and-mycoplasma-pneumoniae-infection
#7
Archana Ramgopal, Aravind Thavamani, Abdulla Ghori
Mycoplasma pneumoniae is a microbe known to affect numerous organ systems, and in particular, can cause neurological manifestations. We describe an otherwise healthy child who presented with acute onset intractable headache with magnetic resonance imaging (MRI) findings consistent with posterior reversible encephalopathy syndrome (PRES), a neurological manifestation that presents with headache, vision changes, altered mental status, or seizures. Our patient did not have any of the common etiologies for PRES reported but tested positive for acute M...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29899773/phenylketonuria-our-experience-in-nine-years-at-a-tertiary-level-referral-institute
#8
Sadanandvalli R Chandra, Rita Christopher, Mane M Daryappa, Rashmi Devaraj
Introduction: Phenyl ketonuria is an inborn error of amino acid metabolism resulting in excessive phenyl alanine levels in blood resulting in a spectrum of neurological defects. Patients and Methods: We retrospectively went through the records of patients diagnosed as Phenyl ketonuria in the last nine years in our team and patients who's data could be accessed were analyzed in detail. Details of laboratory tests, imaging clinical features, course were recorded. Observation: A total of 32 patients were identified in nine years of which data was available only for 15 patients...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29898967/european-trends-in-epilepsy-surgery
#9
Maxime O Baud, Thomas Perneger, Attila Rácz, Max C Pensel, Christian Elger, Bertil Rydenhag, Kristina Malmgren, J Helen Cross, Grainne McKenna, Martin Tisdall, Herm J Lamberink, Sylvain Rheims, Philippe Ryvlin, Jean Isnard, François Mauguière, Alexis Arzimanoglou, Serdar Akkol, Kaancan Deniz, Cigdem Ozkara, Morten Lossius, Ivan Rektor, Reetta Kälviäinen, Lotta-Maria Vanhatalo, Petia Dimova, Krassimir Minkin, Anke Maren Staack, Bernhard J Steinhoff, Adam Kalina, Pavel Krsek, Petr Marusic, Zsofia Jordan, Daniel Fabo, Evelien Carrette, Paul Boon, Saulius Rocka, Rūta Mameniškienė, Serge Vulliemoz, Francesca Pittau, Kees P J Braun, Margitta Seeck
OBJECTIVE: Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. METHODS: Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29896790/de-novo-mutations-of-stxbp1-in-chinese-children-with-early-onset-epileptic-encephalopathy
#10
Tingsong Li, Min Cheng, Juan Wang, Siqi Hong, Mei Li, Shuang Liao, Lingling Xie, Yajun Qin, Li Jiang
OBJECTIVE: To detect syntaxin-binding protein 1 (STXBP1) mutations in Chinese patients with early onset epileptic encephalopathy (EOEE) of unknown etiology. METHODS: Targeted next-generation sequencing was used to identify STXBP1 mutations in 143 Chinese patients with EOEE of unknown etiology. A filtering process was applied to prioritize rare variants of potential functional significance. Then Sanger sequencing was employed to validate the parental origin of the variants...
June 13, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29891404/influenza-associated-neurological-complications-during-2014-2017-in-taiwan
#11
Li-Wen Chen, Chao-Ku Teng, Yi-Shan Tsai, Jieh-Neng Wang, Yi-Fang Tu, Ching-Fen Shen, Ching-Chuan Liu
INTRODUCTION: Seasonal influenza-associated neurological complications had high mortality and morbidity rates in recent studies. We reported influenza-associated encephalitis/encephalopathy in children during 2014-2017 in Taiwan, focusing on neurological presentations, neuroimaging correlations, and critical care managements. MATERIALS/SUBJECTS: During January 1st 2014 to June 30th 2017, pediatric patients reported to the Taiwan Centers for Disease Control surveillance system for severe complicated influenza infections in the hospital were retrospectively reviewed...
June 8, 2018: Brain & Development
https://www.readbyqxmd.com/read/29891351/adverse-events-following-vaccination-with-an-inactivated-vero-cell-culture-derived-japanese-encephalitis-vaccine-in-the-united-states-2012-2016
#12
William L Walker, Susan L Hills, Elaine R Miller, Marc Fischer, Ingrid B Rabe
BACKGROUND: In March 2009, the U.S. Food and Drug Administration licensed an inactivated Vero cell culture-derived Japanese encephalitis vaccine (JE-VC [IXIARO®]) for use in persons aged ≥17 years. In 2013, licensure was extended to include children aged ≥2 months. A previous analysis reviewed adverse events reported to the U.S. Vaccine Adverse Event Reporting System (VAERS) from May 2009 through April 2012. METHODS: We reviewed adverse events reported to VAERS following JE-VC administered from May 1, 2012 through April 30, 2016...
June 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29891079/nonprogressive-congenital-ataxias
#13
Enrico Bertini, Ginevra Zanni, Eugen Boltshauser
The terminology of nonprogressive congenital ataxia (NPCA) refers to a clinically and genetically heterogeneous group of disorders characterized by congenital or early-onset ataxia, but no progression or even improvement on follow-up. Ataxia is preceded by muscular hypotonia and delayed motor (and usually language) milestones. We exclude children with prenatal, perinatal, and postnatal acquired diseases, malformations other than cerebellar hypoplasia, and defined syndromic disorders. Patients with NPCA have a high prevalence of cognitive and language impairments, in addition to increased occurrence of seizures, ocular signs (nystagmus, strabismus), behavior changes, and microcephaly...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29887290/addition-of-cannabidiol-to-current-antiepileptic-therapy-reduces-drop-seizures-in-children-and-adults-with-treatment-resistant-lennox-gastaut-syndrome
#14
Daniel A Ostrovsky, Alan Ehrlich
No abstract text is available yet for this article.
May 1, 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29886041/outcomes-after-acute-symptomatic-seizures-in-children-admitted-to-a-neonatal-neurocritical-care-service
#15
Hannah C Glass, Adam L Numis, Dawn Gano, Varun Bali, Elizabeth E Rogers
BACKGROUND: Neonatal seizures due to acute brain injury are associated with high rates of death, disability, and epilepsy. Our objective was to examine incidence of and risk factors for epilepsy among survivors of acute symptomatic neonatal seizures who were cared for by a neonatal neurocritical care service. METHODS: Neonates with acute symptomatic seizures who were admitted to UCSF Benioff Children's Hospital Neuro-Intensive Care Nursery from July 2008 to June 2014 were considered for inclusion...
April 20, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29885874/two-cases-of-childhood-narcolepsy-mimicking-epileptic-seizures-in-video-eeg-emg
#16
Tomoe Yanagishita, Susumu Ito, Yui Ohtani, Kaoru Eto, Takashi Kanbayashi, Hirokazu Oguni, Satoru Nagata
Narcolepsy is characterized by excessive sleepiness, hypnagogic hallucinations, and sleep paralysis, and can occur with or without cataplexy. Here, we report two children with narcolepsy presenting with cataplexy mimicking epileptic seizures as determined by long-term video-electroencephalography (EEG) and electromyography (EMG) monitoring. Case 1 was a 15-year-old girl presenting with recurrent episodes of "convulsions" and loss of consciousness, who was referred to our hospital with a diagnosis of epilepsy showing "convulsions" and "complex partial seizures"...
June 6, 2018: Brain & Development
https://www.readbyqxmd.com/read/29884735/neurologic-outcomes-in-pediatric-cardiac-arrest-survivors-enrolled-in-the-thapca-trials
#17
Rebecca Ichord, Faye S Silverstein, Beth S Slomine, Russell Telford, James Christensen, Richard Holubkov, J Michael Dean, Frank W Moler
OBJECTIVE: To implement a standardized approach to characterize neurologic outcomes among 12-month survivors in the Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials. METHODS: Two multicenter trials enrolled children age 48 hours to 18 years who remained comatose after cardiac arrest (CA) occurring out-of-hospital (THAPCA-OH, NCT00878644) or in-hospital (THAPCA-IH, NCT00880087); patients were randomized to therapeutic hypothermia or therapeutic normothermia...
June 8, 2018: Neurology
https://www.readbyqxmd.com/read/29883228/effectiveness-of-low-dose-of-rapamycin-in-preventing-seizure-induced-anxiety-like-behavior-cognitive-impairment-and-defects-in-neurogenesis-in-developing-rats
#18
Furong Liu, Meiling Wu, Jiejing Kai, Jingyin Dong, Binbin Zhang, Luna Liu, Feng Zhu, Ling-Hui Zeng
Previous studies have demonstrated that rapamycin prevents seizure-induced anxiety-like behaviors. However, rapamycin had been used at a higher dose of 3mg/kg and resulted in side effects in immature animals. The present work was designed to explore whether a lower dose of rapamycin has similar efficacy but has milder side effects. Acute seizures were induced by injection of pilocarpine at postnatal 10 day Sprague-Dawley rats. Western blot analysis was used to detect changes in mTOR pathway after seizure...
June 8, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29882466/development-of-the-cidss2-score-for-children-with-mild-head-trauma-without-intracranial-injury
#19
Jacob K Greenberg, Yan Yan, Christopher R Carpenter, Angela Lumba-Brown, Martin S Keller, Jose Pineda, Ross C Brownson, David Limbrick
While most children with mild TBI (mTBI) without intracranial injury (ICI) can be safely discharged home from the emergency department, many are admitted to the hospital. To support evidence-based practice, we developed a decision tool to help guide hospital admission decisions. This study was a secondary analysis of a prospective study conducted in 25 emergency departments. We included children under 18 years who had Glasgow Coma Scale score 13-15 head injuries and normal CT scans or skull fractures without significant depression...
June 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29881807/secular-changes-in-severity-of-intellectual-disability-in-tuberous-sclerosis-complex-a-reflection-of-improved-identification-and-treatment-of-epileptic-spasms
#20
Charlotte Tye, Laura E Thomas, Julian R Sampson, Julia Lewis, Finbar O'Callaghan, John R W Yates, Patrick F Bolton
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by mutations in TSC1 or TSC2 . Epilepsy occurs in 80%-90% of affected individuals during their lifetime, and up to one-third of children with TSC will develop epileptic (infantile) spasms, for which vigabatrin has been shown to be particularly effective. Epilepsy severity and epileptic spasms are consistent markers of risk for the development of intellectual impairment in TSC. Although previous studies demonstrate a bimodal distribution of intellectual ability in TSC, recent findings suggest a unimodal distribution, which may reflect a change in IQ distribution over time...
June 2018: Epilepsia Open
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