keyword
https://read.qxmd.com/read/38240537/resuscitation-with-vitamin-c-hydrocortisone-and-thiamin-in-children-with-septic-shock-a-multicenter-randomized-pilot-study
#21
RANDOMIZED CONTROLLED TRIAL
Luregn J Schlapbach, Sainath Raman, David Buckley, Shane George, Megan King, Roberta Ridolfi, Amanda Harley, Michele Cree, Debbie Long, Simon Erickson, Puneet Singh, Marino Festa, Kristen Gibbons, Rinaldo Bellomo
OBJECTIVES: Adjunctive therapy with vitamin C, hydrocortisone, and thiamin has been evaluated in adults, but randomized controlled trial (RCT) data in children are lacking. We aimed to test the feasibility of vitamin C, hydrocortisone, and thiamin in PICU patients with septic shock; and to explore whether the intervention is associated with increased survival free of organ dysfunction. DESIGN: Open-label parallel, pilot RCT multicenter study. The primary endpoint was feasibility...
February 1, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38227781/efficacy-safety-and-complications-of-pigtail-thoracostomy-for-the-treatment-of-pediatric-pleuropneumonia
#22
JOURNAL ARTICLE
Oren Tamary, Arnon Yaari, Zafnat Prokocimer-Yair, Roi Feldman, Ron Berant, Ron Jacob, Nir Samuel
OBJECTIVE: Pigtail thoracostomy (PT) has become the mainstay technique for the drainage of pediatric pleuropneumonic effusions (PLPe). However, its efficacy and complication profile has been questioned when compared with video-assisted thoracoscopic surgery and larger bore traditional tube thoracostomy. The aim of this study was to assess the efficacy, safety, and complications associated with PT. METHODS: A cross-sectional study at a freestanding tertiary children's hospital...
January 16, 2024: Pediatric Emergency Care
https://read.qxmd.com/read/38221820/integration-of-intraosseous-approach-method-in-georgia
#23
JOURNAL ARTICLE
Nino Kikodze, Ketevan Nemsadze
OBJECTIVE: In pediatric emergencies, as in case of shock, the use of intraosseous (IO) route is recommended to get rapid vascular access as soon as possible, as it revealed better outcome. Nevertheless, the IO approach is not used at all and/or is limited because of lack of demand and lack of training on the issue of medical staff. The aim of the study was to test applicable and/or demand of IO in clinics providing pediatric critical care services and assess the opportunities to integrate IO access use in emergency care in Georgia...
January 16, 2024: Pediatric Emergency Care
https://read.qxmd.com/read/38218938/impact-evaluation-of-a-maternal-and-child-cash-transfer-intervention-integrated-with-nutrition-early-childhood-development-and-agriculture-messaging-maziko-ie-a-study-protocol-for-a-cluster-randomised-controlled-trial
#24
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Children in Malawi face high rates of malnutrition and are at risk of not reaching their developmental potential. Community-based childcare centres (CBCCs) can be cost-effective platforms for scaling-up early childhood development (ECD) and nutrition social behaviour change (SBC) interventions. However, evidence also suggests potential synergies from coupling nutrition SBC with cash transfers (CT), given that rural households in Malawi face high levels of poverty and recurring extreme lean season food-security shocks...
January 13, 2024: Trials
https://read.qxmd.com/read/38214810/multisystem-inflammatory-syndrome-in-children-mis-c-a-nationwide-collaborative-study-in-the-greek-population
#25
JOURNAL ARTICLE
Stavroula Lampidi, Despoina Maritsi, Marietta Charakida, Irini Eleftheriou, Evangelia Farmaki, Nikos Spyridis, Konstantina Charisi, Petrina Vantsi, Filippos Filippatos, Kleopatra Skourti, Efimia Papadopoulou-Alataki, Kyriaki Papadopoulou-Legbelou, Parthena Kampouridou, Ioanna N Grivea, Eleni Vergadi, Despoina Gkentzi, Despina Dimou, Patra Koletsi, Lampros Fotis, Theodota Liakopoulou, Aikaterini Agrafiotou, Katerina Kourtesi, Georgios Tsolas, Dimitrios Kafetzis, Vassiliki Papaevangelou, Gabriel Dimitriou, Emmanouil Galanakis, George A Syrogiannopoulos, Vassiliki Spoulou, Athanasios Michos, Emmanuel Roilides, Maria N Tsolia
UNLABELLED: Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe hyperinflammatory condition that may occur following SARS-CoV-2 infection. This retrospective, descriptive study of children hospitalized with multisystem inflammatory syndrome in children (MIS-C) in 12 tertiary care centers from 3/11/2020 to 12/31/2021. Demographics, clinical and laboratory characteristics, treatment and outcomes are described. Among 145 patients (95 males, median age 8.2 years) included, 123 met the WHO criteria for MIS-C, while 112 (77%) had serological evidence of SARS-CoV-2 infection...
January 12, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38206397/nt-probnp-course-during-mis-c-post-covid-19-an-observational-study
#26
JOURNAL ARTICLE
Saïd Bichali, Naïm Ouldali, François Godart, Patrice Maboudou, Ali Houeijeh, Stéphane Leteurtre
Multisystem inflammatory syndrome in children (MIS-C or PIMS-TS) is a severe disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is used for positive and differential diagnosis, diagnosis of complications and severity, and cardiogenic shock prediction. However, contrasting cut-offs have been suggested. The aims of the present study were to compare NT-proBNP values depending on the time of measurement and to describe the NT-proBNP course during the MIS-C episode. The data from a single-centre cohort observational study on the impact of time to diagnosis, defined as the time from first symptom to diagnosis of MIS-C, were used for the purpose of this study, with an extended period of inclusion from May 2020 to April 2023...
January 11, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38204335/updated-case-definition-of-mis-c-and-implications-for-clinical-care
#27
JOURNAL ARTICLE
Megan Day-Lewis, Laura Berbert, Annette Baker, Audrey Dionne, Jane W Newburger, Mary Beth F Son
OBJECTIVES: A broad, surveillance case definition was implemented when multisystem inflammatory syndrome in children (MIS-C) emerged in 2020. In 2023, a revised MIS-C case definition was constructed to improve specificity and reduce misclassification with other pediatric inflammatory conditions. This study aims to describe the impact of the updated definition on the classification of patients with MIS-C and Kawasaki Disease (KD). METHODS: Patients hospitalized from March 2020 to November 2022 with clinician-diagnosed KD and MIS-C at a single center were studied retrospectively...
January 11, 2024: Pediatrics
https://read.qxmd.com/read/38191230/invasive-group-a-streptococcal-disease
#28
JOURNAL ARTICLE
Joannu Ann Varughese, Mahesh Katre, Birendra Rai, Debkrishna Mallick
We report on two children who had presented in a poor clinical state after an initial bout of cough, sore throat and fever for a few days. Both of them had multisystemic involvement with fluid-refractory septic shock requiring ionotropic support, intubation and care in the paediatric intensive care unit. Recent significant rise in scarlet fever has led to a significant increase in the number of invasive group A streptococcal infections with increased mortality in paediatric patients. Both of them had co-infection with influenza, which could have led to an increased risk of invasive group A streptococcal (iGAS) infection...
January 8, 2024: BMJ Case Reports
https://read.qxmd.com/read/38190409/prevalence-mortality-and-aetiology-of-paediatric-shock-in-a-tertiary-hospital-in-malawi-a-cohort-study
#29
JOURNAL ARTICLE
Mercy Kumwenda, Roxanne Assies, Gloria Chathima, Harriet Khofi, Job B M van Woensel, Yamikani Chimalizeni, Josephine Langton, Job C J Calis
Shock is considered one of the most important mechanisms of critical illness in children. However, data on paediatric shock in sub-Saharan Africa is limited, which constrains development of effective treatment strategies. We aimed to describe the prevalence, mortality, and aetiology of paediatric shock in a tertiary hospital in Malawi. Children aged two months to 16 years presenting with shock (FEAST criteria; respiratory distress and/or impaired consciousness, and at least one sign of impaired circulation; capillary refill>3 seconds, cold extremities, weak pulse, or severe tachycardia) to the emergency department were included and followed-up prospectively using routinely collected data between February 2019 and January 2020...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38173688/developing-an-emergency-medicine-assessment-tool-for-medical-interns-within-the-south-african-context-a-modified-delphi-study
#30
JOURNAL ARTICLE
Laurryn Ah Yui, Luan Taljaard, Sian Geraty, Roshen Maharaj
INTRODUCTION: Emergency Medicine is a relatively new specialty in South Africa. Limited data is available regarding junior doctors' competence in managing emergencies, however previous surveys have identified limited teaching and supervision of junior doctors in Emergency Medicine. Currently there is no formal standardised assessment tool to assess an intern's Emergency Medicine competence. The aim of the study was to, through expert opinion and consensus, develop an Emergency Medicine assessment tool to identify a level of appropriate Emergency Medicine knowledge at the end of internship...
March 2024: African Journal of Emergency Medicine Revue
https://read.qxmd.com/read/38161959/a-challenging-diagnosis-of-kawasaki-disease-shock-syndrome-complicated-by-bilateral-pleural-effusion-a-case-report-and-literature-review
#31
Linah Saleh Abbas Alghamdi, Ali Yahya B Alzahrani, Fahad A Alghamdi, Saleh J ALghamdi
Kawasaki disease (KD) is an acute illness primarily affecting children under the age of five. It is characterized by fever and inflammation of small to medium-sized arteries. This case report presents the case of a nine-year-old boy with KD who developed Kawasaki disease shock syndrome (KDSS) complicated by bilateral pleural effusion, which is a rare occurrence. KDSS is defined as KD accompanied by low blood pressure or signs of inadequate blood flow, leading to increased cardiovascular complications. The patient exhibited typical KD symptoms, including conjunctivitis, mucosal changes, rash, extremity swelling, and lymphadenopathy...
November 2023: Curēus
https://read.qxmd.com/read/38154978/-clinical-analysis-of-11-cases-multisystem-inflammatory-syndrome-associated-with-sars-cov-2-omicron-variant-infection-in-children
#32
JOURNAL ARTICLE
H S Zhang, X T Chang, P H Wu, D Y Song, G Ge, W Ding, Z W Hu, G F Wang, Y W Jiang, L P Ye
Objective: To explore the clinical characteristics, diagnosis, treatment, and follow-up of multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 Omicron variant infection. Methods: A retrospective analysis was conducted on clinical data of 11 children with MIS-C, who were admitted to the Department of Pediatrics of Peking University First Hospital from December 2022 to January 2023. Clinical characteristics, treatment, and follow-up of MIS-C were summarized in this study. Results: The 11 cases contained 7 boys and 4 girls, with an age of 4...
January 2, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38151848/multisystem-inflammatory-syndrome-in-children-mis-c-in-a-lowincome-country-what-treatment-should-be-adopted-in-case-of-a-lack-of-immunoglobulin
#33
JOURNAL ARTICLE
Babakhouya Abdeladim, Bouhmidi Massilia, Elouali Aziza, Elhaddar Zohair, Ghanam Ayad, Rkain Maria
INTRODUCTION: In multisystem inflammatory syndrome (MIS-C), children typically present high-grade fever, gastrointestinal symptoms, Kawasaki-like symptoms, and even a toxic shock-like syndrome days to weeks after recovering from SARS-CoV-2 infection. It is important to raise awareness of this condition in order to have early diagnosis and immediate treatment of patients. We have, herein, reported 44 cases of MIS-C with various risk factors and symptoms. Furthermore, we have emphasized the efficacy of experience in treating children with MIS-C with high-dose corticosteroids as an alternative to immunoglobulin in low-income countries...
December 26, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38105983/derivation-validation-and-transcriptomic-assessment-of-pediatric-septic-shock-phenotypes-identified-through-latent-profile-analyses-results-from-a-prospective-multi-center-observational-cohort
#34
Atreya, Bs Min Huang, Andrew R Moore, Hong Zheng, Yehudit Hasin-Brumshtein, Fitzgerald, Scott L Weiss, Natalie Z Cvijanovich, Michael T Bigham, Parag N Jain, Adam J Schwarz, Riad Lutfi, Jeffrey Nowak, Neal J Thomas, Michael Quasney, Mary K Dahmer, Torrey Baines, Bereketeab Haileselassie, Andrew J Lautz, Natalja L Stanski, Stephen W Standage, Md Jennifer M Kaplan, Zingarelli, Sweeney, Purvesh Khatri, Sanchez-Pinto, Rishikesan Kamaleswaran
Background Sepsis poses a grave threat, especially among children, but treatments are limited due to clinical and biological heterogeneity among patients. Thus, there is an urgent need for precise subclassification of patients to guide therapeutic interventions. Methods We used clinical, laboratory, and biomarker data from a prospective multi-center pediatric septic shock cohort to derive phenotypes using latent profile analyses. Thereafter, we trained a support vector machine model to assign phenotypes in a hold-out validation set...
December 6, 2023: Research Square
https://read.qxmd.com/read/38098829/insights-into-the-epidemiology-risk-factors-and-clinical-outcomes-of-carbapenem-resistant-acinetobacter-baumannii-infections-in-critically-ill-children
#35
JOURNAL ARTICLE
Yufei Zhang, Guifeng Xu, Fei Miao, Weichun Huang, Haiying Wang, Xing Wang
BACKGROUND AND AIMS: Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a leading cause of nosocomial infections with an increasing impact on critically ill patients, yet there is limited data on contributing factors. This study was aim to evaluate the prevalence and risk factors, and clinical outcomes of CRAB infections among critically ill children in a tertiary university teaching hospital in China. METHODS: From January 2016 to December 2021, all children diagnosed with nosocomial Acinetobacter baumannii ( A...
2023: Frontiers in Public Health
https://read.qxmd.com/read/38084084/pediatric-sepsis-diagnosis-management-and-sub-phenotypes
#36
JOURNAL ARTICLE
Scott L Weiss, Julie C Fitzgerald
Sepsis and septic shock are major causes of morbidity, mortality, and health care costs for children worldwide, including >3 million deaths annually and, among survivors, risk for new or worsening functional impairments, including reduced quality of life, new respiratory, nutritional, or technological assistance, and recurrent severe infections. Advances in understanding sepsis pathophysiology highlight a need to update the definition and diagnostic criteria for pediatric sepsis and septic shock, whereas new data support an increasing role for automated screening algorithms and biomarker combinations to assist earlier recognition...
January 1, 2024: Pediatrics
https://read.qxmd.com/read/38079262/endotheliopathy-of-trauma-in-children-the-association-of-syndecan-1-with-injury-and-poor-outcomes
#37
JOURNAL ARTICLE
Katrina M Morgan, Elissa Abou-Khalil, Barbara A Gaines, Christine M Leeper
BACKGROUND: The contribution of the endothelium to trauma-induced coagulopathy has not been thoroughly investigated in injured children. METHODS: This is a prospective cohort study of children (age < 18) who presented with a potentially severe injury to an academic pediatric trauma center. Syndecan-1 level was collected on arrival and 24 hours following hospital arrival. Children were categorized as injured vs uninjured based on results of trauma evaluation. Demographics, injury characteristics, vital signs, and clinical labs were recorded...
December 8, 2023: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38078321/short-mid-and-long-term-complications-after-multisystem-inflammatory-syndrome-in-children-over-a-24-month-follow-up-period-in-a-hospital-in-lima-peru-2020-2022
#38
JOURNAL ARTICLE
Giancarlo Alvarado-Gamarra, Matilde Estupiñan-Vigil, Raquel Garcés-Ghilardi, Jesús Domínguez-Rojas, Olguita Del Águila, Katherine Alcalá-Marcos, Rafael Márquez Llanos, Lucie Ecker, Carlos R Celis, Carlos Alva-Diaz, Claudio F Lanata
OBJECTIVE: To determine the short-, mid-, and long-term complications after multisystem inflammatory syndrome in children (MIS-C) over a 24-month follow-up period in a hospital in Lima, Peru, 2020-2022, and to explore differences according to the immunomodulatory treatment received and type of SARS-CoV-2 virus circulating. METHODS: Ambispective 24-month follow-up study in children <14 years of age diagnosed with MIS-C at the Hospital Nacional Edgardo Rebagliati Martins (HNERM)...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38077325/elevated-monocyte-hla-dr-in-pediatric-secondary-hemophagocytic-lymphohistiocytosis-a-retrospective-study
#39
JOURNAL ARTICLE
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey
INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, and its diagnosis may be challenging. In particular, some cases show close similarities to sepsis (fever, organ failure, and high ferritin), but their treatment, while urgent, differ: prompt broad-spectrum antibiotherapy for sepsis and immunosuppressive treatment for HLH. We questioned whether monocyte human leucocyte antigen (mHLA)-DR could be a diagnostic marker for secondary HLH (sHLH). METHODS: We retrospectively reviewed data from patients with a sHLH diagnosis and mHLA-DR quantification...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38063514/pan-valvulitis-in-children-with-kawasaki-disease-a-case-report-and-review-of-the-literature
#40
JOURNAL ARTICLE
Pelayo Leon-Jimenez, Maria Lorenzo-Martin, Cristiana Tomatis-Souverbielle, Shoghik Akoghlanian, Linda Cripe, Octavio Ramilo, Asuncion Mejias
We present a rare case of pan-valvular involvement in a 5-month-old female with Kawasaki disease shock syndrome despite early treatment with intravenous immunoglobulin and corticosteroids. She experienced a favorable outcome after the addition of infliximab, which was guided based on clinical, laboratory and echocardiogram findings, rather than recrudescence of fever, the most common indicator of intravenous immunoglobulin resistance.
December 8, 2023: Pediatric Infectious Disease Journal
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