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https://www.readbyqxmd.com/read/29689452/role-of-the-hspa9-hsc20-chaperone-pair-in-promoting-directional-human-iron-sulfur-cluster-exchange-involving-monothiol-glutaredoxin-5
#1
Joshua A Olive, J A Cowan
Iron‑sulfur clusters are essential cofactors found across all domains of life. Their assembly and transfer are accomplished by highly conserved protein complexes and partners. In eukaryotes a [2Fe-2S] cluster is first assembled in the mitochondria on the iron‑sulfur cluster scaffold protein ISCU in tandem with iron, sulfide, and electron donors. Current models suggest that a chaperone pair interacts with a cluster-bound ISCU to facilitate cluster transfer to a monothiol glutaredoxin. In humans this protein is glutaredoxin 5 (GLRX5) and the cluster can then be exchanged with a variety of target apo proteins...
April 11, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29687277/early-goal-directed-therapy-using-a-physiological-holistic-view-the-andromeda-shock-a-randomized-controlled-trial
#2
Glenn Hernández, Alexandre Biasi Cavalcanti, Gustavo Ospina-Tascón, Fernando Godinho Zampieri, Arnaldo Dubin, F Javier Hurtado, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Maurizio Cecconi, Jean-Louis Teboul, Jan Bakker
BACKGROUND: Septic shock is a highly lethal condition. Early recognition of tissue hypoperfusion and its reversion are key factors for limiting progression to multiple organ dysfunction and death. Lactate-targeted resuscitation is the gold-standard under current guidelines, although it has several pitfalls including that non-hypoxic sources of lactate might predominate in an unknown proportion of patients. Peripheral perfusion-targeted resuscitation might provide a real-time response to increases in flow that could lead to a more timely decision to stop resuscitation, thus avoiding fluid overload and the risks of over-resuscitation...
April 23, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29687041/meta-inflammation-and-cardiometabolic-disease-in-obesity-can-heat-therapy-help
#3
REVIEW
Brett R Ely, Zachary S Clayton, Carrie E McCurdy, Joshua Pfeiffer, Christopher T Minson
Obesity and associated metabolic dysfunction have reached epidemic proportions worldwide. The current theory linking metabolic disease and obesity involves ischemic adipose tissue initiating an inflammatory cascade that results in systemic insulin resistance and may eventually lead to type II diabetes mellitus. Diabetes and associated metabolic dysfunction increase the risk of developing cardiovascular disease and fatal cardiovascular events. By targeting key steps in this process, ischemia and inflammation, this cascade may be prevented or reversed and thus metabolic and cardiovascular health may be preserved in obesity...
2018: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/29686311/rna-n-6-methyladenosine-modification-in-cancers-current-status-and-perspectives
#4
Xiaolan Deng, Rui Su, Hengyou Weng, Huilin Huang, Zejuan Li, Jianjun Chen
N6 -methyladenosine (m6 A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygotic transition. The m6 A modification is deposited by the m6 A methyltransferase complex (MTC; i.e., writer) composed of METTL3, METTL14 and WTAP, and probably also VIRMA and RBM15, and can be removed by m6 A demethylases (i...
April 23, 2018: Cell Research
https://www.readbyqxmd.com/read/29686138/ddri-a-crp-family-member-acts-as-a-major-regulator-for-adaptation-of-deinococcus-radiodurans-to-various-stresses
#5
Laura Meyer, Geneviève Coste, Suzanne Sommer, Jacques Oberto, Fabrice Confalonieri, Pascale Servant, Cécile Pasternak
The <u>D</u>NA <u>d</u>amage <u>r</u>esponse gene ddrI encodes a transcription regulator belonging to the CRP (cAMP Receptor Protein) family. Cells devoid of the DdrI protein exhibit a pleiotropic phenotype, including growth defects, sensitivity to DNA damaging agents and to oxidative stress. Here, we show that the absence of DdrI protein also confers sensitivity to heat shock treatment and several genes involved in heat shock response were shown to be up-regulated in a DdrI dependent manner...
April 23, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29685852/assessment-of-antimicrobiral-prophylaxis-in-transperineal-prostate-biopsy-a-single-center-retrospective-study-of-485-cases
#6
Kyoko Baba, Yoshitaka Sekine, Yoshiyuki Miyazawa, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
To verify the validity of our antimicrobial prophylaxis regimen for transperineal prostate biopsies, we investigated the rate of infectious complications in this procedure. We retrospectively investigated the infectious complications in 485 patients who underwent a transperineal prostate biopsy between 2014 and 2016 at our hospital. In the clinic, we use cefazolin (CEZ) for antimicrobial prophylaxis. Infectious complications were assessed up to postoperative day (POD) 30. Patients with infectious complications were further investigated to determine the site of infection, outbreak day, and type of pathogenic bacteria...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685363/fulminant-type-1-diabetes-mellitus-with-remarkable-elevation-of-serum-pancreatic-enzymes
#7
Mikio Nakajima, Masamitsu Shirokawa, Tomotsugu Nakano, Hideaki Goto
Fulminant type 1 diabetes mellitus progresses extremely rapidly and is accompanied by ketoacidosis. Patients with the disease present at emergency departments with non-specific symptoms, including fever, nausea, vomiting, and abdominal pain. Here, we present a case of fulminant type 1 diabetes mellitus where the patient was initially misdiagnosed with gastroenteritis and acute pancreatitis. A 50-year-old Japanese woman was referred to our hospital with coma and shock. She had presented with nausea, vomiting, abdominal pain and thirst from 5 days before admission, and had been misdiagnosed with gastroenteritis by her primary care physician...
April 14, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29685228/phenotypic-and-genotypic-characteristics-of-staphylococcus-aureus-isolates-from-zoo-and-wild-animals
#8
Andrea T Feßler, Patricia Thomas, Kristin Mühldorfer, Mirjam Grobbel, Julian Brombach, Inga Eichhorn, Stefan Monecke, Ralf Ehricht, Stefan Schwarz
Antimicrobial resistance of Staphylococcus aureus is a major problem in human and veterinary medicine. The aim of this study was to characterise S. aureus isolates from wild and zoo animals mainly associated with bacterial infections. In total, 23 S. aureus isolates, including nine from wild animals and 14 from zoo animals, were obtained during routine diagnostics. All isolates were subjected to multilocus sequence typing (MLST), spa typing, macrorestriction analysis with subsequent SmaI pulsed-field gelelectrophoresis (PFGE), antimicrobial susceptibility testing and S...
May 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29683753/fluid-therapy-and-shock-an-integrative-literature-review
#9
Joana Silva, Luís Gonçalves, Patrícia Pontífice Sousa
BACKGROUND: shock refers to a physiological situation that puts life at risk. Its early identification and the timely institution of therapeutic measures can avoid death. Despite the frequent administration of fluid therapy as a treatment for shock, the type and dose of fluids to be delivered remain undetermined. AIM: to determine the type of fluids to be administered and the type of approach to be performed in the different types of shock. METHOD: integrative literature review...
April 26, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29682763/differential-expression-of-annexin-2-spink1-and-hsp60-predict-progression-of-prostate-cancer-through-bifurcated-who-gleason-score-categories-in-african-american-men
#10
Desta A Beyene, Tammey J Naab, Norma F Kanarek, Victor Apprey, Ashwini Esnakula, Farahan A Khan, Marc R Blackman, Collis A Brown, Tamaro S Hudson
BACKGROUND: Although studies have observed several markers correlate with progression of prostate cancer (PCa), no specific markers have been identified that accurately predict the progression of this disease, even in African American (AA) men who are generally at higher risk than other ethnic groups. The primary goal of this study was to explore whether three markers could predict the progression of PCa. METHOD: We investigated protein expression of Annexin 2 (ANX2), serine peptidase inhibitor, kazal type 1(SPINK1)/tumor-associated trypsin inhibitor (TATI), and heat shock protein 60 (Hsp60) in 79 archival human prostate trans-rectal ultrasound (TRUS) biopsy tissues according to a modified World Health Organization (WHO) classification: normal (WHO1a), Gleason Score (GS6 (WHO1b), GS7 subgroups (WHO2 = 3 + 4, WHO3 = 4 + 3), GS8 (WHO4), and GS9-10 (WHO5)...
April 22, 2018: Prostate
https://www.readbyqxmd.com/read/29682607/the-role-of-hsp40-conserved-motifs-in-the-response-to-cytotoxic-stress
#11
Samantha J Sojourner, Willie M Graham, Aurellia M Whitmore, Jana S Miles, Devon Freeny, Hernan Flores-Rozas
Doxorubicin, a highly effective therapeutic agent against several types of cancer, is associated with serious side-effects, particularly cardiotoxicity. In addition, drug resistance leads to unsuccessful outcomes in many patients. There are no current biomarkers to indicate doxorubicin treatment response in patients. To understand the mechanisms of toxicity of doxorubicin, a whole-genome sensitivity screen was performed in the yeast S. cerevisiae . A deletion mutant of the yeast DNAJ (YDJ1), a J-domain heat-shock protein 40 (HSP40) was among the most sensitive strains...
2018: Journal of Nature and Science
https://www.readbyqxmd.com/read/29682201/molecular-signatures-associated-with-tumor-specific-immune-response-in-melanoma-patients-treated-with-dendritic-cell-based-immunotherapy
#12
Tamara García-Salum, Andrea Villablanca, Franziska Matthäus, Andrés Tittarelli, Mauricio Baeza, Cristián Pereda, M Alejandra Gleisner, Fermín E González, Mercedes N López, Jörg D Hoheisel, Johannes Norgauer, Peter J Gebicke-Haerter, Flavio Salazar-Onfray
Purpose: We previously showed that autologous dendritic cells (DCs) loaded with an allogeneic heat shock (HS)-conditioned melanoma cell-derived lysate, called TRIMEL, induce T-cell-mediated immune responses in stage IV melanoma patients. Importantly, a positive delayed-type hypersensitivity (DTH) reaction against TRIMEL after vaccination, correlated with patients prolonged survival. Furthermore, we observed that DTH reaction was associated with a differential response pattern reflected in the presence of distinct cell subpopulations in peripheral blood...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29678918/impact-of-currently-marketed-tampons-and-menstrual-cups-on-staphylococcus-aureus-growth-and-tsst-1-production-in-vitro
#13
Louis Nonfoux, Myriam Chiaruzzi, Cédric Badiou, Jessica Baude, Anne Tristan, Jean Thioulouse, Daniel Muller, Claire Prigent Combaret, Gérard Lina
Fifteen currently marketed intravaginal protection products (11 types of tampon and four menstrual cups) were tested by the modified tampon sac method to determine their effect on Staphylococcus aureus growth and toxic shock toxin 1 (TSST-1) production. Most tampons reduced S. aureus growth and TSST-1 production, with differences based on brand and composition, and S. aureus growth was higher in de-structured than in unaltered tampons. We observed higher S. aureus growth and toxin production in menstrual cups than in tampons, potentially due to the additional air introduced to the bag by cups, with differences based on cup composition and size...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29678661/role-of-heat-shock-transcription-factor-1-hsf1-upregulated-macrophage-in-ameliorating-pressure-overload-induced-heart-failure-in-mice
#14
Peizhao Du, Yaowei Chang, Fangjie Dai, Chunyan Wei, Qi Zhang, Jiming Li
In order to explore the role of macrophages in HSF1-mediated alleviation of heart failure, mice model of pressure overload-induced heart failure was established using transverse aortic constriction (TAC). Changes in cardiac function and morphology were studied in TAC and SHAM groups using ultrasonic device, tissue staining, electron microscopy, real-time quantitative polymerase chain reaction (RT-QPCR), and Western blotting. We found that mice in the TAC group showed evidence of impaired cardiac function and aggravation of fibrosis on ultrasonic and histopathological examination when compared to those in the SHAM group...
April 17, 2018: Gene
https://www.readbyqxmd.com/read/29678642/heat-shock-protein-70-accelerates-atherosclerosis-by-downregulating-the-expression-of-abca1-and-abcg1-through-the-jnk-elk-1-pathway
#15
Zhen-Wang Zhao, Min Zhang, Ling-Yan Chen, Duo Gong, Xiao-Dan Xia, Xiao-Hua Yu, Si-Qi Wang, Xiang Ou, Xiao-Yan Dai, Xi-Long Zheng, Da-Wei Zhang, Chao-Ke Tang
BACKGROUND AND AIMS: Recent studies have suggested that heat shock protein 70 (HSP70) may play critical roles in cardiovascular disease. However, the effects of HSP70 on the development of atherosclerosis in apoE-/- mice remain largely unknown. This study was to investigate the role and potential mechanism of HSP70 in atherosclerosis. METHODS: HSP70 was overexpressed in apoE-/- mice and THP-1-derived macrophages with lentiviral vectors. Oil Red O, hematoxylin-eosin, and Masson staining were performed to evaluate atherosclerotic plaque in apoE-/- mice fed the Western type diet...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29677582/maternal-nicotine-exposure-effects-on-adolescent-learning-and-memory-are-abolished-in-alpha-%C3%AE-2-nicotinic-acetylcholine-receptor-null-mutant-mice
#16
Celina Mojica, Yu Bai, Shahrdad Lotfipour
The objective of the current study is to test the hypothesis that the deletion of alpha(α)2* nicotinic acetylcholine receptors (nAChRs) (encoded by the Chrna2 gene) ablate maternal nicotine-induced learning and memory deficits in adolescent mice. We use a pre-exposure-dependent contextual fear conditioning behavioral paradigm that is highly hippocampus-dependent. Adolescent wild type and α2-null mutant offspring are exposed to vehicle or maternal nicotine exposure (200 μg/ml, expressed as base) in the drinking water throughout pregnancy until weaning...
April 9, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29675997/hearing-vulnerability-after-noise-exposure-in-a-mouse-model-of-reactive-oxygen-species-overproduction
#17
Shigefumi Morioka, Hirofumi Sakaguchi, Taro Yamaguchi, Yuzuru Ninoyu, Hiroaki Mohri, Takashi Nakamura, Yasuo Hisa, Kiyokazu Ogita, Naoaki Saito, Takehiko Ueyama
Previous studies have convincingly argued that reactive oxygen species (ROS) contribute to the development of several major types of sensorineural hearing loss, such as noise-induced hearing loss (NIHL), drug-induced hearing loss, and age-related hearing loss. However, the underlying molecular mechanisms induced by ROS in these pathologies remain unclear. To resolve this issue, we established an in vivo model of ROS overproduction by generating a transgenic (TG) mouse line expressing the human NADPH oxidase 4 (NOX4, NOX4-TG mice), which is a constitutively active ROS-producing enzyme that does not require stimulation or an activator...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29675571/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-in-takotsubo-syndrome
#18
Thomas Stiermaier, Francesco Santoro, Tobias Graf, Francesca Guastafierro, Nicola Tarantino, Luisa De Gennaro, Pasquale Caldarola, Matteo Di Biase, Holger Thiele, Natale D Brunetti, Christian Möller, Ingo Eitel
BACKGROUND: Takotsubo syndrome (TTS), a form of acute transient heart failure, has been associated with severe complications and considerable mortality rates. N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) might serve as a marker to identify high-risk patients but has not yet been investigated regarding prognostic implications in TTS. Aim of this study was to determine the short- and long-term prognostic utility of NT-proBNP in patients with TTS. METHODS: The predictive value of admission NT-proBNP was assessed in an international, multicenter study including 177 consecutive TTS patients...
April 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29672920/targeting-hsp60-by-subcutaneous-injections-of-jetpei-hsp60-shrna-destabilizes-cytoplasmic-survivin-and-inhibits-hepatocellular-carcinoma-growth
#19
Ya-Hui Huang, Kwang-Huei Lin, Jao-Song Yu, Ting-Jung Wu, Wei-Chen Lee, Chuck C-K Chao, Tai-Long Pan, Chau-Ting Yeh
Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppressed cell proliferation in two HCC cell lines with HSP60-silencing, and also indicated survivin is involved in this regulatory process in vitro and in vivo. However, HSP60-silencing in normal human hepatocytes only resulted in a minimal reduction of cell proliferation but without effects on cell apoptosis...
April 19, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29672544/stress-pre-conditioning-with-temperature-uv-and-gamma-radiation-induces-tolerance-against-phosphine-toxicity
#20
Saad M Alzahrani, Paul R Ebert
Phosphine is the only general use fumigant for the protection of stored grain, though its long-term utility is threatened by the emergence of highly phosphine-resistant pests. Given this precarious situation, it is essential to identify factors, such as stress preconditioning, that interfere with the efficacy of phosphine fumigation. We used Caenorhabditis elegans as a model organism to test the effect of pre-exposure to heat and cold shock, UV and gamma irradiation on phosphine potency. Heat shock significantly increased tolerance to phosphine by 3-fold in wild-type nematodes, a process that was dependent on the master regulator of the heat shock response, HSF-1...
2018: PloS One
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