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Thromboangiitis obliterans

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https://www.readbyqxmd.com/read/27902617/efficacy-of-bosentan-in-patients-with-refractory-thromboangiitis-obliterans-buerger-disease-a-case-series-and-review-of-the-literature
#1
Javier Narváez, Carmen García-Gómez, Lorenzo Álvarez, Pilar Santo, María Aparicio, María Pascual, Mercè López de Recalde, Helena Borrell, Joan M Nolla
The cornerstone of therapy in thromboangiitis obliterans (TAO) is complete abstinence from tobacco. In addition to discontinuation of cigarette smoking, very few pharmacological and surgical options of controversial efficacy are available to date. New therapeutic options with greater efficacy are clearly needed to properly manage these patients.In this preliminary study, we assessed the effectiveness and safety of bosentan in a case series of 8 adults with TAO and severe ischemic ulceronecrotic lesions who were treated with bosentan after inadequate response to platelet inhibitors, vasodilators, and intravenous alprostadil...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27785045/buerger-s-disease-providing-integrated-care
#2
REVIEW
Peter Klein-Weigel, Theresa Sophie Volz, Leonora Zange, Jutta Richter
Buerger's disease, also known as thromboangiitis obliterans (TAO), is a segmental inflammatory disease affecting small- and medium-sized vessels, which is strongly associated with tobacco use. Although the etiology is still unknown, recent studies suggest an immunopathogenesis. Diagnosis is based on clinical and angiomorphologic criteria, including age, history of smoking, clinical presentation with distal extremity ischemia, and the absence of other risk factors for atherosclerosis, autoimmune disease, hypercoagulable states, or embolic disease...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27723695/-the-results-of-combined-surgical-treatment-of-thromboangiitis-obliterans-and-critical-lower-limb-ischemia-using-prolonged-epidural-analgesia-and-autohemotherapy-with-ozone
#3
N S Abyshov, A G Abdullaev, E D Zakirdzhaev, R A Guliev, M B Akhmedov, G T Tagizade, G M Zeinalova, L D Mamedova
AIM: to evaluate the results of combined treatment of thromboangiitis obliterans with severe lower limb ischemia using prolonged epidural anaesthesia and autohemotherapy with ozone. MATERIAL AND METHODS: It was analyzed treatment of 125 patients with thromboangiitis obliterans and severe lower limb ischemia. Patients were divided into 2 groups. Control group consisted of 60 patients who underwent conventional perioperative therapy with anticoagulants, antiplatelet agents, dextrans, metabolic drugs, glucocorticoids, angioprotectors, narcotic and non-narcotic analgesics...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27647524/hyperbaric-oxygen-therapy-in-the-treatment-of-fontaine-stage-iv-thromboangiitis-obliterans
#4
Dogus Hemsinli, Safiye Tuba Kaplan, Sahin Kaplan, Furkan Yildirim
Ischemic wounds unresponsive to standard treatment in thromboangiitis obliterans are associated with amputation, morbidity, and mortality. In this study, hyperbaric oxygen therapy was added to standard treatment of 36 patients with thromboangiitis obliterans with ischemic ulcerated wounds in the extremities. Full recovery was observed in 52.7% of cases (25% at discharge, 27.7% during follow-up). Resting pain after treatment decreased significantly compared to pretreatment levels based on visual analog scale scores (7...
September 19, 2016: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/27574381/investigation-of-the-etiology-of-anemia-in-thromboangiitis-obliterans
#5
Mohammad Mehdi Akbarin, Hassan Ravari, Ataollah Rajabnejad, Narges Valizadeh, Bahare Fazeli
During a review of patients admitted with thromboangiitis obliterans (TAO), there was evidence of normochromic normocytic anemia and abrupt changes in hemoglobin (Hgb) levels in patients with several hospital admissions. Therefore, the evidence of hemolytic anemia was evaluated based on 37 banked plasma samples taken from Caucasian male TAO patients during disease exacerbation between 2012 and 2014. The patients' hospital records, including clinical manifestations and complete blood count, were evaluated. The following tests were performed on all samples: indirect antiglobulin test (IAT), C-reactive protein (CRP), high-sensitivity CRP (hsCRP), lactate dehydrogenase (LDH), haptoglobin, indirect bilirubin, d-aspartate aminotransferase (AST), and d-alanine aminotransferase (ALT)...
September 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27515062/vasa-nervorum-as-the-source-of-corkscrew-collaterals-in-thromboangiitis-obliterans-buerger-s-disease
#6
B Kocak, E D Ustun
No abstract text is available yet for this article.
October 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27464297/the-incidence-and-prevalence-of-thromboangiitis-obliterans-in-taiwan-a-nationwide-population-based-analysis-of-data-collected-from-2002-to-2011
#7
Jie-Fu Zheng, Yi-Ming Chen, Der-Yuan Chen, Ching-Heng Lin, Hsin-Hua Chen
OBJECTIVE: To estimate the incidence and prevalence of thromboangiitis obliterans in Taiwan in the period spanning from 2002 to 2011. METHODS: We identified all incident and prevalent cases with a diagnosis of thromboangiitis obliterans (International Classification of Diseases, Ninth Revision code 443.1) in the period spanning from 2002 to 2011 using Taiwan's National Health Insurance Research Database. We calculated the age- and sex-specific incidence and prevalence rates of thromboangiitis obliterans during the study period...
July 2016: Clinics
https://www.readbyqxmd.com/read/27459490/-pad-prevalence-in-russian-federation
#8
A F Kharazov, A O Kalyaev, A A Isaev
BACKGROUND: Currently there is no data on peripheral arterial disease prevalence in Russia. AIM: To estimate prevalence of patients with symptomatic low limb ischemia (LLI) in Russian Federation on 2014. PATIENTS AND METHODS: «League for patient' protection» had sent questionnaires for all regional health departments asking to name prevalence of ICD-10 codes I70.2 (atherosclerosis of arteries of extremities) and I73.1 (thromboangiitis obliterans (Buerger)) on 2014...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27452071/-cerebral-manifestations-of-thromboangiitis-obliterans-case-report
#9
Csongor Aszalos, Eleni Dongó, Zsuzsanna Farkas, Attila Kollár, Péter Magyar, György Várallyay, Dániel Bereczki, Ildikó Vastagh
Thromboangiits obliterans (Buerger's disease) is a non-atherosclerotic, segmental inflammatory and obliterative disease affecting small and medium sized arteries and veins. The etiology is still unknown, but it is in close relationship with tobacco use. Symptoms begin under the age of 45 years and the undulating course is typical. Patients usually present with acute and chronic ischemic or infectious acral lesions. Diagnosis is usually based on clinical and angiographic criteria and it is important to exclude autoimmune disease, thrombophilia, diabetes, and proximal embolic sources...
July 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27342528/-preliminary-clinical-efficiency-of-autologous-peripheral-blood-mononuclear-cells-for-treating-critical-limb-ischemia-of-thromboangiitis-obliterans
#10
Jing-Yi Yu, Shang-Zhu Li, Li-Hua Wu, Hong-Min Li, Wen-Hui Gao, Ya-Li Zheng, Ning Xu, Qing-Guo Liu, Jun-Fan Li, Chun-Hua Liu, Yi-Min Hu, Ping-Ping Huang
OBJECTIVE: To evaluate the long-term clinical effect of autologous peripheral blood mononuclear cells (PB-MNC) on critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) patients. METHODS: The clinical data of 22 patients with CLI caused by TAO from July 2004 to May 2013 were analyzed retrospectively, 22 patients were divided into 2 groups; out of them 12 cases in one group were treated with granulocyte colony-stimulating factor (G-CSF)-mobilized autologous peripheral blood mononuclear cells (auto-PBMNC group), 10 cases in another group received conservative treatment (CT group)...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27188859/politics-culture-and-the-legitimacy-of-disease-the-case-of-buerger-s-disease
#11
Stephen J Lockwood, Scott C Bresler, Scott R Granter
Thromboangiitis obliterans (TAO) or Buerger's disease is a rare form of vasculitis with distinctive clinical and pathological features that carries significant morbidity, often leading to amputation, and is strongly associated with tobacco smoking. Despite its distinctive clinicopathological characteristics, the existence of TAO as an entity sui generis was challenged for many years as it languished in relative obscurity. Then, as societal attitudes towards smoking changed, TAO not only became accepted as a disease entity, it quite literally became a poster child to illustrate the ills of smoking...
September 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27144003/thromboangiitis-obliterans-buerger-s-disease
#12
REVIEW
Ignacio J Rivera-Chavarría, José D Brenes-Gutiérrez
Thromboangiitis Obliterans is a non-atherosclerotic inflammatory disease of unknown etiology, which has a strong association with tobacco. We present current concepts on the pathophysiology and diagnosis, as well as a review in treatments.
May 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27141205/buerger-s-disease-presenting-as-a-testicular-mass-a-rare-presentation-of-an-uncommon-disease
#13
Jay A Roberts, Jon-Paul Meyer
Thromboangiitis obliterans is an uncommon nonatherosclerotic segmental inflammatory disease that predominantly affects the small and medium-sized arteries and veins of the distal extremities. It was first described in 1879 and is also known as Buerger's disease. Buerger's usually begins with ischemia of small vessels producing digital infarcts and may progress to more proximal arteries and veins, producing claudication of the feet, legs, hands, or arms. Tobacco smoking is essential to the initiation and the progression of disease and it typically occurs in males under the age of 45 years...
April 2016: Urology Annals
https://www.readbyqxmd.com/read/27122278/repeated-small-bowel-resection-in-a-patient-with-buerger-s-disease-and-intestinal-involvement
#14
Ali Enshaei, Babak Hajipour, Naser Masoudi
Buerger's disease, also called thromboangiitis obliterans, is a recurrent and an uncommon vaso-occlusive inflammatory disease, which typically affects small and medium-sized arteries, veins and nerves of the upper and lower extremities. Mesenteric and multisystem involvement of two or more organs is extremely rare. Here we report the case of a 39-year-old male heavy smoker who had undergone four repetitive laparotomies and multiple small bowel resections for ischaemic involvement of Buerger's disease. He had below-the-knee amputation of the right leg and finger of the left hand because of that disease before bowel involvement...
April 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27012074/-thromboangiitis-obliterans-overlapping-with-atherosclerotic-occlusive-arterial-disease-small-mesenteric-artery-involvement-by-thromboangiitis-obliterans
#15
REVIEW
Doron Rimar, Michael Rozenbaum, Gleb Slobodin, Nina Boulman, Lisa KaLy, Itzhak Rosner
INTRODUCTION: Thromboangiitis obliterans is an inflammatory occlusive vascular disease of young smokers that commonly involves the small and medium sized arteries and veins of the extremities. An important differential diagnosis of thromboangiitis obliterans is atherosclerotic arterial disease. An atypical presentation of thromboangiitis obliterans by involvement of mesenteric arteries has been described sporadically. CASE PRESENTATION: We report the case of a patient presenting with Raynaud's phenomenon, ischemia of the upper and lower extremities, as well as mesenteric ischemia...
January 2016: Harefuah
https://www.readbyqxmd.com/read/26967103/pharmacological-treatment-for-buerger-s-disease
#16
REVIEW
Daniel G Cacione, Cristiane R Macedo, Jose C C Baptista-Silva
BACKGROUND: Buerger's disease (thromboangiitis obliterans) is a non-atherosclerotic, segmental inflammatory pathology that most commonly affects the small and medium sized arteries, veins, and nerves in the upper and lower extremities. The etiology is unknown, but involves hereditary susceptibility, tobacco exposure, immune and coagulation responses. In many cases, there is no possibility of revascularization to improve the condition. Pharmacological treatment is an option for patients with severe complications, such as ischaemic ulcers or rest pain...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26935815/increased-serum-hmgb-1-icam-1-and-metalloproteinase-9-levels-in-buerger-s-patients
#17
Giovanni De Caridi, Alessandra Bitto, Mafalda Massara, Giovanni Pallio, Gabriele Pizzino, Raffaele Serra, Domenica Altavilla, Francesco Squadrito, Francesco Spinelli
BACKGROUND: Thromboangiitis obliterans (TAO), or Buerger's disease, is an inflammatory occlusive disorder that affects the limb arteries of young smokers. In the aetiology of TAO the immune system appears to play a critical role; however, information on the aspects involved in the evolution of vascular tissue inflammation and of this disease are still limited. OBJECTIVE: This study was carried out to investigate HMGB-1 (high mobility group box-1), MMP (matrix metalloproteinase)- 2, MMP-9, MMP-11 and ICAM (intercellular adhesion molecule)-1 circulating levels in subjects with Buerger's disease...
2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/26914127/autologous-peripheral-blood-stem-cell-transplantation-to-treat-thromboangiitis-obliterans-preliminary-results
#18
J Wan, Y Yang, Z-H Ma, Y Sun, Y-Q Liu, G-J Li, G-M Zhang
OBJECTIVE: To investigate the efficiency of autologous peripheral blood stem cell transplantation (APBSCT) to treat severe the lower limbs ischemia caused by thromboangiitis obliterans (TAO). PATIENTS AND METHODS: From April 2007 to December 2014, a total of 64 patients with TAO (80 affected limbs) received APBSCT at our hospital. The treatment effect was evaluated by subjective indicators including pains and cold sensation of the affected limbs, combined with objective indicators including claudication distance, ankle brachial index (ABI), transcutaneous oxygen pressure (TcPO2) and skin temperature...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26905708/smoking-and-thromboangitis-obliterans-are-they-related
#19
P Sapkota, P Budhathoky, S Mathew
INTRODUCTION: In 1908 Leo Buerger first gave the world the clinical picture of this dreadful disease which he called Thromboangitis Obliterans. Virtually all investigators believe that smoking or tobacco use in some form is a requirement for the diagnosis of Thromboangitis Obliterans. We studied the demographic profile and smoking pattern of patients with Thromboangiitis Obliterans. METHODS: Retrospective study carried out in a tertiary level hospital of South India from 1st January 1997 to 31st December 2003...
April 2014: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/26891489/-frontline-of-vascular-regenerative-therapy-for-refractory-peripheral-arterial-diseases
#20
REVIEW
Masaaki Miyamoto, Hajime Takagi, Yoshiaki Kubota, Akihito Tetsuka, Shuhei Tara, Wataru Shimizu, Yoshimitsu Fukushima, Shinichiro Kumida, Yasuhiko Tabata
No abstract text is available yet for this article.
November 2015: Nihon Jibiinkoka Gakkai Kaiho
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