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Thromboangiitis obliterans

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https://www.readbyqxmd.com/read/29768374/treatment-of-multiple-refractory-ankle-ulcerations-in-thromboangiitis-obliterans-a-case-report
#1
Zheng-Hao Huang, San-Yuan Kuo, Yu-Hsiang Chiu, Hsiang-Cheng Chen, Chun-Chi Lu
RATIONALE: Thromboangiitis obliterans (TAOs, or Buerger's disease) present as a non-atherosclerotic segmental occlusive vasculitis within medium- and small-sized blood vessels. TAO frequently occurs in young adults and is associated with cigarette smoking. At present, there are no accurately defined treatments for TAO. PATIENT CONCERNS: A 34-year-old Asian woman with a 20-year history of heavy cigarette smoking and recurrent, small, and self-limited lower limb ulcerations since adolescence, presented with persisting unhealed ulcerations on both ankles for 6 months...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766003/the-status-of-nitric-oxide-and-its-backup-heme-oxygenase-1-in-thromboangiitis-obliterans
#2
Ali Aliee, Farnaz Zahedi Avval, Hossein Taheri, Saeedeh Mehraban Moghadam, Mohammad Soukhtanloo, Daryoush Hamidi Alamdari, Bahare Fazeli
Background: Until recently, a gene polymorphism in the promoter region of endothelial nitric oxide synthase has been suggested as a risk factor for thromboangiitis obliterans (TAO) development. The aim of this study was to compare the metabolites of nitric oxide (NO) and its backup, heme-oxygenase-1 (HMOX1), between TAO patients and those of a smoking control group matched by race, age, sex, and smoking habits. Methods: Twenty-four male Caucasian TAO patients and 20 male Caucasian controls enrolled in the study...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29751125/anti-inflammatory-activities-and-potential-mechanisms-of-phenolic-acids-isolated-from-salvia-miltiorrhiza-f-alba-roots-in-thp-1-macrophages
#3
Haimei Liu, Shuli Ma, Hongrui Xia, Hongxiang Lou, Faliang Zhu, Longru Sun
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at local clinics, especially for the remedy of thromboangiitis obliterans (TAO) more than 100 years. Phenolic acids are one of the major effective constituents of RSMA, and some studies have linked phenolic acids with anti-inflammatory functions. AIM OF THE STUDY: The purpose of this research was to isolate phenolic acids from RSMA and investigate their anti-inflammatory effects and potential mechanisms...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29596344/treatment-of-arsenite-intoxication-induced-peripheral-vasculopathy-with-mesenchymal-stem-cells
#4
Yi-Hung Chiang, Chai-Chin Lin, Yen-Chung Chen, Oscar K Lee
Arsenite (As), a notorious toxic metal, is ubiquitously distributed in the earth and poses a serious threat to human health. Histopathological lesions of As intoxication are known as thromboangiitis obliterans, which are resistant to current treatment and often lead to lower limb amputation. In this study, we attempt to find that treatment with mesenchymal stem cells (MSCs) may be effective for As-induced vasculopathy. We first conducted an in vitro study with a co-culture system containing human MSCs and human umbilical vein endothelial cells (HUVECs) and treated individual and co-cultured cells with various concentrations of arsenite...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29557099/hyperbaric-oxygen-treatment-in-thromboangiitis-obliterans-a-retrospective-clinical-audit
#5
Dogus Hemsinli, Gokalp Altun, Safiye Tuba Kaplan, Furkan Yildirim, Gamze Cebi
INTRODUCTION: Wounds refractory to standard treatment in patients with thromboangiitis obliterans (TAO, Buerger's disease) are associated with amputation, other morbidity and mortality. The purpose of this study was to investigate the effect of hyperbaric oxygen treatment (HBOT) in patients with TAO. MATERIALS AND METHODS: Ninety-seven patients with TAO with ischaemic wounds treated between January 2007 and July 2016 were included in this dual-centre, non-randomised, retrospective study...
March 31, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29556267/effect-of-revascularization-on-il-6-and-tnf-%C3%AE-in-patients-with-thromboangiitis-obliterans
#6
Shifeng Wu, Xin Sun, Wei Wu, Dazhi Shi, Tao Jiang
The aim of the study was to investigate the effects of revascularization in treating patients with thromboangiitis obliterans (TAO), to analyze the prognosis of TAO. The treatment group comprised 32 patients with TAO of lower limbs who were selected between March 2012 and March 2017. Patients in the treatment group were treated with revascularization (vascular bypass surgery, catheter-directed thrombolysis and angioplasty, endovascular angioplasty + stening, thromboectomy and/or endarterectomy) + Western medicine...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29471870/autologous-bone-marrow-derived-mononuclear-cell-therapy-in-chinese-patients-with-critical-limb-ischemia-due-to-thromboangiitis-obliterans-10-year-results
#7
Jianming Guo, Lianrui Guo, Shijun Cui, Zhu Tong, Alan Dardik, Yongquan Gu
BACKGROUND: For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cells (ABMMNCs) to determine the safety and efficacy of ABMMNC therapy in patients with critical limb ischemia due to TAO. METHODS: This was a retrospective chart review from a single university hospital vascular surgery center between January 2005 and July 2006...
February 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29421414/how-to-treat-a-patient-with-thromboangiitis-obliterans-a-systematic-review
#8
REVIEW
Bahare Fazeli, Maliheh Dadgar Moghadam, Shabnam Niroumand
To date, there is still no treatment protocol for patients with thromboangiitis obliterans (TAO) who are also afflicted with critical limb ischemia (CLI). Smoking cessation on its own cannot be considered a treatment for the purposes of salvaging a limb of a TAO patient with CLI. The aim of this review was to evaluate different studies of various treatment protocols for avoiding amputation in TAO patients. A systematic search for relevant studies dating from 1990 to the end of 2016 was performed on the PubMed, SCOPUS, and Science Direct databases...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29386474/long-term-clinical-outcomes-survey-of-bone-marrow-derived-cell-therapy-in-critical-limb-ischemia-in-japan
#9
Kazuhisa Kondo, Kenji Yanishi, Ryo Hayashida, Satoshi Shintani, Rei Shibata, Kenta Murotani, Masahiko Ando, Masaaki Mizuno, Tadami Fujiwara, Toyoaki Murohara, Satoaki Matoba
BACKGROUND: The Therapeutic Angiogenesis by Cell Transplantation (TACT) trial demonstrated the efficacy and safety of autologous bone marrow-derived mononuclear cells (BM-MNCs) in patients with critical limb ischemia (CLI). The present study aimed to assess the long-term clinical outcomes of therapeutic angiogenesis using autologous BM-MNC implantation under advanced medical treatment in Japan.Methods and Results:The study was retrospective, observational, and non-controlled. We assessed no-option CLI patients who had BM-MNC implantation performed in 10 institutes...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29339086/the-il-6-stat3-pathway-regulates-adhesion-molecules-and-cytoskeleton-of-endothelial-cells-in-thromboangiitis-obliterans
#10
Zheng Wei, Wenjing Jiang, Hengzhen Wang, Hali Li, Bo Tang, Bing Liu, Hongchi Jiang, Xueying Sun
Thromboangiitis obliterans (TAO) (also known as Buerger's disease) is an inflammatory vascular disease that predominantly affects small- and medium-sized blood vessels of extremities. Endothelial cells play critical roles in the initiation and progression of this disease, but the underlying mechanisms remain unclear. In the present study, we demonstrate that patients with TAO had significantly higher levels of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in their plasmas, and the involved arterial tissues expressed higher levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), ICAM-1 and VCAM-1...
April 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29237360/endovascular-treatment-of-thromboangiitis-obliterans-buerger-s-disease
#11
REVIEW
Mohammad-Hadi S Modaghegh, Shahab Hafezi
PURPOSE: When critical limb ischemia (CLI) occurs in patients with thromboangiitis obliterans (TAO) or Buerger's disease, smoking cessation alone may be insufficient to relieve rest pain and promote wound healing. Accordingly, adjunctive measures are warranted to restore adequate blood flow required for limb salvage. This study aimed to evaluate the feasibility and efficacy of percutaneous transluminal angioplasty (PTA) for the treatment of patients with TAO and CLI. In addition, a review of the literature on endovascular management of TAO is included...
February 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29211372/-thromboangiitis-obliterans-notions-for-practice
#12
Luca Calanca, Adriano Alatri, Caroline Krieger, Jean-Marc Corpataux, Lucia Mazzolai
Thromboangiitis obliterans is an occlusive vasculopathy affecting small- and medium-size arteries. It can result in severe ischemic status. Thrombophlebitis can be associated. The exact etiology has still to be elucidated. Smoking is the main contributing factor. Diagnosis is based on clinic and paraclinic context, as well as exclusion of other vascular pathologies. Its management consists in complete smoking cessation and instauration of vasodilator treatment. Revascularization is an option that has to be evaluated on a case by case basis...
December 6, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29142485/unexpected-inflammation-in-the-sympathetic-ganglia-in-thromboangiitis-obliterans
#13
Mahdi Farzadnia, Hassan Ravari, Mitra Masoudian, Narges Valizadeh, Bahare Fazeli
The aim of this study was to inspect more closely the microscopic and molecular sympathetic ganglia histology in thromboangiitis obliterans (TAO). The paraffin block and frozen RNAlater-treated tissue of the lumbar sympathetic ganglia of 19 TAO Caucasian male patients were evaluated. The gene expression of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) markers in the frozen RNAlater-treated sympathetic ganglia tissues were evaluated by real-time polymerase chain reaction. Unexpectedly, lymphocyte infiltration was observed in all of the histological sections, ranging from scattered to moderate lymphocyte infiltration...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28917511/successful-percutaneous-transcatheter-angioplasty-of-radial-artery-in-thromboangiitis-obliterans-buerger-s-disease
#14
Tomohiko Taniguchi, Toru Higuchi, Junichi Tazaki, Naritatsu Saito, Takeshi Kimura
No abstract text is available yet for this article.
November 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28887249/chronic-nonatherosclerotic-occlusive-popliteal-artery-disease
#15
Jun Gyo Gwon, Yong-Jae Kwon, Young Jin Han, Yong-Pil Cho, Tae-Won Kwon
BACKGROUND: The outcomes of revascularization of nonatherosclerotic occlusive popliteal artery disease are unknown. Therefore, the objective of this study was to analyze the outcomes of recanalization of nonatherosclerotic occlusive popliteal artery disease, the results of which would be useful in creating surgical strategies for such cases. METHODS: From January 2000 to December 2015, a total of 22 patients with nonatherosclerotic occlusive popliteal artery disease underwent open surgical repair...
February 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28864202/pathogenesis-of-thromboangiitis-obliterans-gene-polymorphism-and-immunoregulation-of-human-vascular-endothelial-cells
#16
REVIEW
Xiao-Lei Sun, Betty Yuen-Kwan Law, Ivo Ricardo de Seabra Rodrigues Dias, Simon Wing Fai Mok, Yan-Zheng He, Vincent Kam-Wai Wong
Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental, inflammatory vasculitis, which commonly affects the small- and medium-sized arteries of the upper and lower extremities. Despite its discovery more than a century ago, little progress has been made in its treatment. Unless the pathogenesis is elucidated, therapeutic approaches will be limited. The purpose of this review article is to collate current knowledge of mechanisms for the pathogenesis of thromboangiitis obliterans and to propose potential mechanisms from a genetic and immunoreactive point of view for its inception...
August 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28776069/porcine-arteriogenesis-based-on-vasa-vasorum-in-a-novel-semi-acute-occlusion-model-using-high-resolution-imaging
#17
Jonathan M Harnoss, Florian Krackhardt, Zully Ritter, Susanne Granzow, Dieter Felsenberg, Konrad Neumann, Lilach O Lerman, Fabian Riediger, Philipp Hillmeister, Peter Bramlage, Ivo R Buschmann
Bridging collaterals (BC) develop in several chronic total artery occlusion diseases, and can prevent extensive myocardial necrosis. Yet, their origin, growth process, and histo-morphology are still unclear. Since vasa vasorum (VV) may take part in collateralization, we hypothesized that VV are the basis for BCs. To comprehensively investigate this arteriogenesis process, we used high-resolution imaging, including corrosion casts, post-mortem angiography with stereoscopy, micro-CT, and immunohistology, in combination with a novel semi-acute vessel occlusion model...
August 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28759424/treatment-of-thromboangiitis-obliterans-using-smoking-cessation-and-far-infrared-therapy-a-case-study
#18
I-Han Chiang, Shyi-Gen Chen, Yuan-Sheng Tzeng
Thromboangiitis obliterans (Buerger's disease) is a rare, nonatherosclerotic segmental inflammatory vasculitis that commonly involves small- and medium-sized vessels. Ischemic tenderness impairs patient quality of life and places patients at high risk for amputation. The only definitive known treatment is smoking cessation. Far-infrared (FIR) therapy has shown promising effects on blood flow and healing, but its use in patients with Buerger's disease has not been reported. A 31-year-old man with a 15-pack-year history of smoking, no drug abuse, and no other significant medical history, trauma, or family history diagnosed with thromboangiitis obliterans presented for care at the authors' clinic...
July 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28753096/conservative-treatment-of-patients-with-thromboangiitis-obliterans-or-cannabis-associated-arteritis-presenting-with-critical-lower-limb-ischaemia
#19
George Galyfos, Stavros Kerasidis, Georgios Kastrisios, Sotirios Giannakakis, Ioannis Sachmpazidis, Christiana Anastasiadou, Georgios Geropapas, Anastasios Papapetrou, Gerasimos Papacharalampous, Chrisostomos Maltezos
BACKGROUND: Proper management of patients with thromboangiitis obliterans (TAO) or cannabis-associated arteritis (CAA), presenting with critical lower limb ischaemia (CLI) remains controversial, and data are limited. PATIENTS AND METHODS: Patients with TAO or CAA presenting with CLI between 2011 and 2016 were retrospectively evaluated. Patients requiring primary intervention were excluded. Conservative treatment included: (a) weight-adjusted bemiparin plus six hours/day intravenous iloprost for 28 days, (b) aspirin (100 mg/day) plus cilostazol (100 mg twice/day) after discharge, and (c) strict recommendations/monitoring for smoking cessation...
October 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28743226/endovascular-therapy-outcomes-and-intravascular-ultrasound-findings-in-thromboangiitis-obliterans-buerger-s-disease
#20
Osami Kawarada, Teruyoshi Kume, Shinobu Ayabe, Takako Nakaya, Michikazu Nakai, Kunihiro Nishimura, Teruo Noguchi, Yoshiaki Yokoi, Hisao Ogawa, Satoshi Yasuda
PURPOSE: To investigate outcomes of contemporary endovascular therapy and intravascular ultrasound (IVUS) findings in thromboangiitis obliterans (TAO) patients. METHODS: Between April 2007 and January 2016, 20 patients (mean age 45±8 years; 16 men) underwent endovascular therapy for TAO-related lesions in 25 consecutive limbs. Subjects exhibited a broad array of clinical symptoms, including critical limb ischemia (n=15) and claudication (10) in the lower (n=20) and upper (n=5) limbs...
August 2017: Journal of Endovascular Therapy
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