keyword
https://read.qxmd.com/read/38464982/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-and-fine-needle-biopsy-to-generate-pancreatic-cancer-organoids-randomized-trial
#21
JOURNAL ARTICLE
Johannes Roman Wiessner, Felix Orben, Arlett Schäfer, Lisa Fricke, Günter Schneider, Maximilian Reichert, Alexander Herner, Ulrich Mayr, Veit Phillip, Matthias Treiber, Guido von Figura, Mohamed Abdelhafez, Roland M Schmid, Christoph Schlag
Background and study aims The prognosis for pancreatic cancer remains poor. Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model systems such as organoids have the potential to substantially increase the depth of information from biopsy material by functional and molecular characterization. We compared the extent to which the use of fine-needle aspiration needles (FNA, 22G) or fine-needle biopsy needles (FNB, 22G) influences the generation of pancreatic cancer patient-derived organoids (PDOs) to establish endoscopic standards of organoid technology...
March 2024: Endoscopy International Open
https://read.qxmd.com/read/38463732/microcystic-serous-cystadenoma-of-the-pancreas-causing-biliary-obstruction-a-case-report-and-review-of-the-literature
#22
Sydney Bland, William Thompson Iii
Cystic tumors account for 15% of pancreatic tumors. Of these, serous microcystic adenomas represent 1-2% of pancreatic exocrine neoplasms. While typically benign, a small percentage possess malignant potential. Given imaging improvements, serous cystadenomas are being identified more frequently. A 63-year-old female was admitted with complaints of jaundice and unintentional weight loss. Abdominal computed tomography scan showed a 16 cm obstructive pancreatic mass near the porta hepatis region. Endoscopic ultrasonography and fine needle aspiration biopsy indicated a large pancreatic head cystic mass favoring serous microcystadenoma causing biliary and some pyloric obstruction...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38463493/-18-f-fdg-pet-ct-assists-the-diagnosis-of-primary-pancreatic-lymphoma-two-case-reports-and-literature-review
#23
Jian Wang, Yujing Zhou, Hongwei Liu, Jianli Zhou, Xin Li
Primary pancreatic lymphoma (PPL) is a rare malignancy, which is defined as a mass centered in pancreas with involvement of contiguous lymph nodes and distant spread may exist. Accurate diagnosis of PPL prior to pathological confirmation remains challenging, underscoring the critical significance of preoperative imaging assessments. This case report collected two instances of PPL that underwent initial evaluation via 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) between August 2021 and July 2022...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38463375/early-endoscopic-management-of-an-infected-acute-necrotic-collection-misdiagnosed-as-a-pancreatic-pseudocyst-a-case-report
#24
Hong-Ying Zhang, Chen-Cong He
BACKGROUND: Infected acute necrotic collection (ANC) is a fatal complication of acute pancreatitis with substantial morbidity and mortality. Drainage plays an exceedingly important role as the first step in invasive intervention for infected necrosis; however, there is great controversy about the optimal drainage time, and better treatment should be explored. CASE SUMMARY: We report the case of a 43-year-old man who was admitted to the hospital with severe intake reduction due to early satiety 2 wk after treatment for acute pancreatitis; conservative treatment was ineffective, and a pancreatic pseudocyst was suspected on contrast-enhanced computed tomography (CT)...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463147/fulminant-emphysematous-pancreatitis-diagnosis-time-counts
#25
Basel Darawsha, Subhi Mansour, Tawfik Fahoum, Naseem Azzam, Yoram Kluger, Ahmad Assalia, Safi Khuri
Emphysematous pancreatitis (EP), a severe form of necrotizing infection of the pancreas, is an extremely rare medical emergency with high rates of mortality. It is characterized by intraparenchymal pancreatic or peri-pancreatic air due to either monomicrobial or polymicrobial infection with gas-forming bacteria or due to entero-pancreatic fistula. EP is classified according to timing from disease onset when air bubble signs were detected on computed tomography (CT) scan, as early onset (within 2 weeks from disease onset) or late (more than 2 weeks from disease onset)...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38460184/development-of-a-ct-based-radiomics-clinical-model-to-diagnose-acute-pancreatitis-on-nonobvious-findings-on-ct-in-children-with-pancreaticobiliary-maljunction
#26
JOURNAL ARTICLE
Tian-Na Cai, Lian Zhao, Yang Yang, Hui-Min Mao, Shun-Gen Huang, Wan-Liang Guo
OBJECTIVES: Since neither abdominal pain nor pancreatic enzyme elevation is specific for acute pancreatitis (AP), the diagnosis of AP in patients with pancreaticobiliary maljunction (PBM) may be challenging when the pancreas appears normal or nonobvious on computed tomography (CT). This study aimed to develop a quantitative radiomics-based nomogram of pancreatic CT for identifying AP in children with PBM who have nonobvious findings on CT. METHODS: PBM patients with a diagnosis of AP evaluated at the Children's Hospital of Soochow University from June 2015 to October 2022 were retrospectively reviewed...
March 9, 2024: British Journal of Radiology
https://read.qxmd.com/read/38458594/tumor-associated-macrophages-drive-glycolysis-through-the-il-8-stat3-glut3-signaling-pathway-in-pancreatic-cancer-progression
#27
JOURNAL ARTICLE
Ziyi Zhong, Kege Yang, Yunlong Li, Shurui Zhou, Hanming Yao, Yue Zhao, Yuzhou Huang, Jinmao Zou, Yaqing Li, Jiajia Li, Guoda Lian, Kaihong Huang, Shaojie Chen
Glycolytic metabolism is a hallmark of pancreatic ductal adenocarcinoma (PDAC), and tumor-associated stromal cells play important roles in tumor metabolism. We previously reported that tumor-associated macrophages (TAMs) facilitate PDAC progression. However, little is known about whether TAMs are involved in regulating glycolysis in PDAC. Here, we found a positive correlation between CD68+ TAM infiltration and FDG maximal standardized uptake (FDG SUVmax) on PET-CT images of PDAC. We discovered that the glycolytic gene set was prominently enriched in the high TAM infiltration group through Gene Set Enrichment Analysis using The Cancer Genome Atlas database...
March 6, 2024: Cancer Letters
https://read.qxmd.com/read/38457597/nomogram-model-for-predicting-early-recurrence-for-resectable-pancreatic-cancer-a-multicenter-study
#28
MULTICENTER STUDY
Quan Man, Huifang Pang, Yuexiang Liang, Shaofei Chang, Junjin Wang, Song Gao
Pancreatic cancer is a highly aggressive malignancy that is characterized by early metastasis, high recurrence, and therapy resistance. Early recurrence after surgery is one of the important reasons affecting the prognosis of pancreatic cancer. This study aimed to establish an accurate preoperative nomogram model for predicting early recurrence (ER) for resectable pancreatic adenocarcinoma. We retrospectively analyzed patients who underwent pancreatectomy for pancreatic ductal adenocarcinoma between January 2011 and December 2020...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457581/the-ct-guided-percutaneous-drainage-of-pancreatic-pseudocyst-accompanied-by-pseudoaneurysm-a-case-report
#29
JOURNAL ARTICLE
Qimin Yang, Bing Li, Bai Jin Tao Sun, Xiangkai Zhong, Zhiqiang Qiu, Hanfeng Yang
RATIONALE: This case report discusses the CT-guided percutaneous drainage of a pancreatic pseudocyst accompanied by a pseudoaneurysm. Pancreatic pseudocysts can erode the peripancreatic artery and produce pseudoaneurysms. This is rare, but it can be life-threatening. PATIENT CONCERNS: The case presented involves a 58-year-old female who was diagnosed with pancreatic cancer and underwent surgical treatment. She presented with hematochezia, dizziness, and hypodynamic findings with no obvious cause...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457070/a-case-of-progressive-xanthogranulomatous-pancreatitis-with-splenic-abscess
#30
JOURNAL ARTICLE
Keiji Nagata, Kojiro Nakamura, Taku Iida, Junji Iwasaki, Ryo Ito, Satsuki Asai, Misa Ishihara, Toshiyuki Hata, Atsushi Itami, Takahisa Kyogoku
Xanthogranulomatous inflammation is a chronic inflammatory reaction microscopically characterized by aggregation of foamy histiocytes, fibrous tissue, and infiltration of various inflammatory cells. In contrast to xanthogranulomatous inflammation in the gallbladder or kidney, xanthogranulomatous pancreatitis is rare. We herein present a case of xanthogranulomatous pancreatitis in a patient who underwent distal pancreatectomy with splenectomy under preoperative suspicion of a pancreatic pseudocyst or pancreatic tumor...
March 8, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38455481/impact-of-a-robotic-system-on-intra-abdominal-infectious-complications-after-minimally-invasive-gastrectomy-in-patients-with-gastric-cancer-a-propensity-score-matching-analysis-regarding-visceral-obesity
#31
JOURNAL ARTICLE
Naoshi Kubo, Katsunobu Sakurai, Tsuyoshi Hasegawa, Yutaka Tamamori, Yasuhito Iseki, Takafumi Nishii, Sadatoshi Shimizu, Toru Inue, Yukio Nishiguchi, Kiyoshi Maeda
BACKGROUND: The efficacy of robotic gastrectomy (RG) on postoperative complications in patients with gastric cancer (GC) is unclear in terms of the volume of intra-abdominal fat tissue. PATIENTS AND METHODS: We enrolled 403 patients with GC who had minimally invasive surgery between January 2015 and July 2022. During this time, 197 RG and 206 laparoscopic gastrectomies (LG) were performed on the study participants. According to the computed tomography scan, patients were defined as having or not having visceral obesity based on the visceral fatty area (VFA)...
March 2024: Annals of Gastroenterological Surgery
https://read.qxmd.com/read/38453822/pancreatic-adenocarcinoma-treated-with-surgical-resection-toceranib-phosphate-and-firocoxib-in-a-dog-a-case-report
#32
JOURNAL ARTICLE
Manuel Fuertes-Recuero, Esther Vázquez-Fernández, Guillermo Lizasoain-Sánz, Amanda Arroba-Alonso, Alejandro Sánchez-López, Elena Martínez-de-Merlo, María Suárez-Redondo, Gustavo Ortiz-Diez
Exocrine pancreatic carcinomas are rarely reported in dogs. A ductal pancreatic adenocarcinoma in a 10-year-old intact beagle is described in this report. The diagnosis was made based on clinical signs, imaging (abdominal ultrasound and CT scan) and histopathology. Treatment consisted of partial right lobe pancreatectomy followed by adjuvant therapy with toceranib phosphate (Palladia®) and firocoxib (Previcox®) for six months. The treatment was well tolerated, and the survival time was 445 days. To our knowledge, this is the longest survival reported in the literature for a dog diagnosed with exocrine pancreatic adenocarcinoma...
March 8, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38453389/effect-of-x-ray-tube-on-image-quality-and-pancreatic-ductal-adenocarcinoma-conspicuity-in-pancreatic-protocol-dual-energy-ct
#33
JOURNAL ARTICLE
Y Noda, Y Takai, T Suto, N Yamada, T Mori, N Kawai, T Kaga, F Hyodo, H Kato, M Matsuo
AIM: To compare the radiation dose, image quality, and conspicuity of pancreatic ductal adenocarcinoma (PDAC) in pancreatic protocol dual-energy computed tomography (CT) between two X-ray tubes mounted in the same CT machine. MATERIAL AND METHODS: This retrospective study comprised 80 patients (median age, 73 years; 45 men) who underwent pancreatic protocol dual-energy CT from January 2019 to March 2022 using either old (Group A, n=41) or new (Group B, n=39) X-ray tubes mounted in the same CT machine...
April 2024: Clinical Radiology
https://read.qxmd.com/read/38452643/a-case-report-of-primary-pancreatic-lymphoma-revealed-by-an-acute-pancreatitis
#34
Rahma Daoud, Sadok Ben Jabra, Mohamed Ali Chaouch, Hiba Ben Hassine, Mohamed Zayati, Faouzi Noomen
INTRODUCTION: Primary pancreatic lymphoma (PPL) is a rare malignancy. Diffuse large B-cell lymphoma is the predominant subtype, often affecting the pancreatic head in elderly males. Due to its rarity and nonspecific symptoms, PPL is frequently misdiagnosed, leading to unnecessary surgeries. This case report discusses the diagnosis and management of PPL in a 47-year-old female, emphasizing the challenges in its identification. CASE PRESENTATION: A 47-year-old female with no medical history presented with severe epigastric pain and jaundice...
March 5, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38452123/bone-loss-over-time-and-risk-of-osteoporosis-in-advanced-pancreatic-cancer
#35
JOURNAL ARTICLE
Tsuyoshi Takeda, Takashi Sasaki, Takeshi Okamoto, Tatsuki Hirai, Takahiro Ishitsuka, Manabu Yamada, Hiroki Nakagawa, Takaaki Furukawa, Takafumi Mie, Akiyoshi Kasuga, Masato Ozaka, Naoki Sasahira
BACKGROUND: Pancreatic cancer has a high risk of developing osteoporosis. However, the impact of osteoporosis has not been well-studied. This study aimed to evaluate bone loss over time and risk of osteoporosis in patients with advanced pancreatic cancer. METHODS: We retrospectively examined consecutive patients with unresectable pancreatic cancer who had evaluable computed tomography before treatment and at 1-year follow-up. Bone mineral density at the first lumbar vertebra was measured on computed tomography, and osteoporosis was defined as bone mineral density < 135 Hounsfield units...
March 7, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38451882/successful-endoscopic-treatment-of-a-pancreatic-pseudocyst-in-a-patient-with-situs-inversus-totalis-and-upper-gi-duplication
#36
JOURNAL ARTICLE
Marko Kozyk, Olexandr Y Usenko, Steven A Kessler, Viktor P Shkarban, Ivan S Tereshkevych, Ivan V Babii, Oleksandr M Sanzharov, Kateryna Strubchevska
BACKGROUND Duplication of the gastrointestinal tract is a rare congenital malformation that can develop in any part of the digestive tract. These duplications may be asymptomatic into adult age. Situs inversus totalis is a rare congenital anomaly characterized by a mirror transposition of thoracic and abdominal organs. We present a case of a pancreatic pseudocyst in a patient with a combination of situs inversus totalis and doubling of the esophagus, stomach, and first part of the duodenum. CASE REPORT A 64-year-old woman presented with epigastric pain...
March 7, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38451583/temporal-progression-of-pancreatic-cancer-computed-tomography-findings-until-diagnosis-a-large-scale-multicenter-study
#37
JOURNAL ARTICLE
Masanori Gonda, Atsuhiro Masuda, Takashi Kobayashi, Takao Iemoto, Saori Kakuyama, Takeshi Ezaki, Takuya Ikegawa, Yuichi Hirata, Hidetaka Tsumura, Kyohei Ogisu, Ryota Nakano, Seiji Fujigaki, Takashi Nakagawa, Megumi Takagi, Kodai Yamanaka, Yu Sato, Koichi Fujita, Keisuke Furumatsu, Takao Kato, Arata Sakai, Hideyuki Shiomi, Tsuyoshi Sanuki, Yoshifumi Arisaka, Yoshihiro Okabe, Hirochika Toyama, Keitaro Sofue, Yuzo Kodama
BACKGROUND: Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation have been identified as early signs of pancreatic ductal adenocarcinoma. However, limited evidence exists regarding their temporal progression due to previous study limitations with restricted case numbers. OBJECTIVE: To ascertain a more precise frequency assessment of suspicious pancreatic ductal adenocarcinoma findings as well as delineate the temporal progression of them. METHODS: A multicenter retrospective study was conducted on patients diagnosed with pancreatic ductal adenocarcinoma between 2015 and 2021...
March 7, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38451411/simultaneous-gastric-pancreatic-and-renal-metastasis-from-poorly-differentiated-hepatocellular-carcinoma
#38
JOURNAL ARTICLE
Manabu Uchikoshi, Takayoshi Ito, Yoko Nakajima, Ikuya Sugiura, Shoujirou Uozumi, Yuu Shimozuma, Masashi Sakaki, Yasuyuki Ohira, Toshiko Yamochi, Hitoshi Yoshida
Common extrahepatic metastasis sites of hepatocellular carcinoma (HCC) are the lungs, adrenal glands, and bones. Herein, we report a rare case of metastatic gastric, pancreatic, and renal tumors from HCC simultaneously, and review the relevant literature. A 75-year-old woman presented with right hypochondralgia, appetite loss, and weight loss. Computed tomography revealed suspected metastatic liver, lung, and renal tumors. A blood test revealed a leukocyte count of 26,210/μL and a high inflammatory reaction...
March 7, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38450696/hiv-associated-malignancies-presenting-as-acute-pancreatitis-a-case-series
#39
JOURNAL ARTICLE
F Madela, F Anderson, G B Nhlonzi, S R Thomson
BACKGROUND: Acute pancreatitis (AP) may be the presenting symptom in a small percentage of patients harbouring pancreatic or extra pancreatic tumours. This case series aims to describe the pathological spectrum of tumours detected in two AP cohorts from a high HIV-endemic region. METHODS: Prospectively collected databases of patients admitted with AP over two periods 2001 to 2010 and 2013 to 2015, were retrospectively evaluated to detect those with pancreatic and extra-pancreatic tumours...
November 2023: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://read.qxmd.com/read/38450271/a-choledochal-cyst-type-iva-in-a-child-treated-with-roux-en-y-hepaticojejunostomy
#40
JOURNAL ARTICLE
Sulaiman Yusuf, Alivia R Nuriyanto, Nurul Nadia, Muntadhar Muntadhar, Yumna Muzakkir, Nurhayani D Susanti, Zain Al-Shather, Fenny Harrika
A choledochal cyst is a bile duct anomaly that disrupts the transportation of bile from the liver to the gallbladder and small intestine. Choledochal cysts are rare, occurring in approximately one out of every 100,000 to 150,000 children in Western countries, with a girls-to-boys ratio of 4:1. Immediate surgery to excise the cyst and construct a biliary-enteric continuity is necessary to treat this condition. This case-report aimed to present a child with choledochal cyst type IVa who underwent a Roux-en-Y hepaticojejunostomy...
August 2023: Narra J
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