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https://www.readbyqxmd.com/read/29785537/differentiation-of-benign-and-malignant-ampullary-obstruction-by-multi-row-detector-ct
#1
Wirana Angthong, Kran Jiarakoop, Kaan Tangtiang
PURPOSE: To determine useful CT parameters to differentiate ampullary carcinomas from benign ampullary obstruction. MATERIALS AND METHODS: This study included 93 patients who underwent abdominal CT, 31 patients with ampullary carcinomas, and 62 patients with benign ampullary obstruction. Two radiologists independently evaluated CT parameters then reached consensus decisions. Statistically significant CT parameters were identified through univariate and multivariate analyses...
May 21, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29785120/association-between-nr5a2-and-the-risk-of-pancreatic-cancer-especially-among-caucasians-a-meta-analysis-of-case-control-studies
#2
Qun Chen, Hao Yuan, Guo-Dong Shi, Yang Wu, Dong-Fang Liu, Yu-Ting Lin, Lei Chen, Wan-Li Ge, Kuirong Jiang, Yi Miao
Background: Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its potential attributing factors, we pooled the updated literatures to evaluate the association between NR5A2 polymorphism and the risk of pancreatic cancer in this meta-analysis...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785074/challenges-in-diagnosis-of-pancreatic-cancer
#3
REVIEW
Lulu Zhang, Santosh Sanagapalli, Alina Stoita
Pancreatic cancer is a growing source of cancer related death, yet has poor survival rates which have not improved in the last few decades. Its high mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis and the lack of standardised international guidelines in assessing suspicious pancreatic masses. This review aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of available diagnostic technology...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29784597/the-association-between-portal-system-vein-diameters-and-outcomes-in-acute-pancreatitis
#4
X J N M Smeets, G Litjens, D W da Costa, W Kievit, H C van Santvoort, M G H Besselink, P Fockens, M J Bruno, J J Kolkman, J P H Drenth, T L Bollen, E J M van Geenen
BACKGROUND/OBJECTIVES: Acute pancreatitis (AP) progresses to necrotizing pancreatitis in 15% of cases. An important pathophysiological mechanism in AP is third spacing of fluids, which leads to intravascular volume depletion. This results in a reduced splanchnic circulation and reduced venous return. Non-visualisation of the portal and splenic vein on early computed tomography (CT) scan, which might be the result of smaller vein diameter due to decreased venous flow, is associated with infected necrosis and mortality in AP...
May 15, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29782393/clinical-and-prognostic-value-of-18f-fdg-pet-ct-in-restaging-of-pancreatic-cancer
#5
Domenico Albano, Demetrio Familiari, Roberta Gentile, Salvatore Scalisi, Federico Midiri, Marco Messina, Massimiliano Spada, Maria C Fornito, Massimo Galia, Massimo Midiri, Pierpaolo Alongi
AIM: The aim of this retrospective multicentre study was to evaluate the clinical and prognostic effect of fluorine-18-fluorodeoxyglucose (F-FDG)-PET/computed tomography (CT) in the restaging process of pancreatic cancer (PC). MATERIALS AND METHODS: Data from patients treated for primary PC, who underwent F-FDG-PET/CT for suspicious of disease progression, were collected. Accuracy was assessed employing conventional diagnostic procedures, multidisciplinary team case notes, further F-FDG-PET/CT scans and/or follow-up...
May 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29780601/a-comparison-of-apache-ii-bisap-ranson-s-score-and-modified-ctsi-in-predicting-the-severity-of-acute-pancreatitis-based-on-the-2012-revised-atlanta-classification
#6
Anubhav Harshit Kumar, Mahavir Singh Griwan
Objective: Our aim was to prospectively compare the Accuracy of Acute Physiology and Chronic Health Evaluation (APACHE) II, Bedside Index of Severity in Acute Pancreatitis (BISAP), Ranson's score and modified Computed Tomography Severity Index (CTSI) in predicting the severity of acute pancreatitis based on Atlanta 2012 definitions in a tertiary care hospital in northern India. Methods: Fifty patients with acute pancreatitis admitted to our hospital during the period of March 2015 to September 2016 were included in the study...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29777518/total-pancreatic-necrosis-after-organophosphate-intoxication
#7
Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu
Cases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodide...
May 18, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29771770/biliary-stenosis-and-gastric-outlet-obstruction-late-complications-after-acute-pancreatitis-with-pancreatic-duct-disruption
#8
Motokazu Sugimoto, David P Sonntag, Greggory S Flint, Cody J Boyce, John C Kirkham, Tyler J Harris, Sean M Carr, Brent D Nelson, Don A Bell, Joshua G Barton, L William Traverso
OBJECTIVES: Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS: Between September 2010 and August 2014, 141 patients showed pancreatic collections on computed tomography. Percutaneous drainage was primarily performed for patients with signs or symptoms of uncontrolled pancreatic juice leakage...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29770302/percutaneous-microwave-thermosphere-ablation-of-pancreatic-tumours
#9
Anna Maria Ierardi, Pierpaolo Biondetti, Andrea Coppola, Enrico Maria Fumarola, Alberto Magenta Biasina, Salvatore Alessio Angileri, Gianpaolo Carrafiello
Background: In oncologic field, thermo-ablative procedures have spread more and more. Percutaneous microwave ablation (MWA) showed same benefits and some advantages over radiofrequency ablation (RFA). To date, a disadvantage of both was the not totally predictable size and shape of ablation volume. The aim of this study was to assess feasibility and safety of MWA in nonresectable pancreatic head cancer using a new technology of MW with high power (100 W) and frequency of 2,450 MH. Methods: Five patients with pancreatic head cancer treated with percutaneous MWA under ultrasound guidance were retrospectively reviewed...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29766732/-remission-of-the-disease-associated-related-with-immunoglobulin-igg4-accompanied-by-multiple-lymphadenopathy-after-treatment-with-rituximab-and-dexamethasone-a-case-report
#10
Zdeněk Adam, Zita Chovancová, Markéta Nová, Pavel Fabian, Zdeněk Řehák, Renata Koukalová, Marek Slávik, Luděk Pour, Marta Krejčí, Aleš Čermák, Zdeněk Král, Jiří Mayer
A disease associated with immunoglobulin IgG4 is a rare unit with very variable symptoms. We describe the course and treatment of the disease in a patient who presented with multiple lymphadenopathy and infiltrates in the area of the retroperitoneum and pelvis and signs of chronic sclerosing pancreatitis. The disease was clinically manifested by a significant loss of weight, but also by a loss of perception of taste and smell. The diagnosis was made based on a high amount of IgG4 expressing plasma cells in the sampled tissue and an increased concentration of immunoglobulins of type IgG and mainly subclass IG4...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29766302/technique-safety-and-feasibility-of-eus-guided-radiofrequency-ablation-in-unresectable-pancreatic-cancer
#11
Filippo Scopelliti, Antonio Pea, Rita Conigliaro, Giovanni Butturini, Isabella Frigerio, Paolo Regi, Alessandro Giardino, Helga Bertani, Marina Paini, Paolo Pederzoli, Roberto Girelli
BACKGROUND AND AIMS: Radiofrequency ablation (RFA) is a well-recognized local ablative technique applied in the treatment of different solid tumors. Intraoperative RFA has been used for non-metastatic unresectable pancreatic ductal adenocarcinoma (PDAC), showing increased overall survival in retrospective studies. A novel RFA probe has recently been developed, allowing RFA under endoscopic ultrasound (EUS) guidance. Aim of the present study was to assess the feasibility and safety of EUS-guided RFA for unresectable PDACs...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29766227/noncontrast-computed-tomography-factors-predictive-of-extracorporeal-shock-wave-lithotripsy-outcomes-in-patients-with-pancreatic-duct-stones
#12
Ri Liu, Weiwei Su, Jing Gong, Yu Zhang, Jianping Lu
PURPOSE: To assess the usefulness of factors unique to NCCT for the prediction of ESWL outcomes in patients with pancreatic duct stones. MATERIALS AND METHODS: We retrospectively evaluated 148 patients with multiple PDS who had undergone ESWL therapy. All patients received an examination for NCCT both before and after ESWL. The following parameters were measured and recorded: patient characteristics including sex and age; NCCT parameters including mean stone length, mean stone volumes before and after ESWL, mean value of CT attenuation, standard deviation of CT attenuation, variation coefficient of CT attenuation, skin-to-stone distance, and pancreatic duct diameter; ESWL outcome indexes including stone clearance rate calculated using the formula [Formula: see text], and the number of ESWL sessions...
May 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29761331/folfirinox-versus-gemcitabine-nab-paclitaxel-for-neoadjuvant-treatment-of-resectable-and-borderline-resectable-pancreatic-head-adenocarcinoma
#13
Mashaal Dhir, Mazen S Zenati, Ahmad Hamad, Aatur D Singhi, Nathan Bahary, Melissa E Hogg, Herbert J Zeh, Amer H Zureikat
BACKGROUND: Both FOLFIRINOX and gemcitabine/nab-paclitaxel (G-nP) are used increasingly in the neoadjuvant treatment (NAT) of pancreatic ductal adenocarcinoma (PDA). This study aimed to compare neoadjuvant FOLFIRINOX and G-nP in the treatment of resectable (R) and borderline resectable (BR) head PDA. METHODS: A single-institution retrospective review of R and BR patients undergoing pancreaticoduodenectomy after NAT with FOLFIRINOX or G-nP was performed. Comparative analysis was performed using inverse-probability-weighted (IPW) estimators...
May 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29757718/us-of-right-upper-quadrant-pain-in-the-emergency-department-diagnosing-beyond-gallbladder-and-biliary-disease
#14
Gayatri Joshi, Kevin A Crawford, Tarek N Hanna, Keith D Herr, Nirvikar Dahiya, Christine O Menias
Acute cholecystitis is the most common diagnosable cause for right upper quadrant abdominal (RUQ) pain in patients who present to the emergency department (ED). However, over one-third of patients initially thought to have acute cholecystitis actually have RUQ pain attributable to other causes. Ultrasonography (US) is the primary imaging modality of choice for initial imaging assessment and serves as a fast, cost-effective, and dynamic modality to provide a definitive diagnosis or a considerably narrowed list of differential possibilities...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29755906/rare-forms-of-castleman-disease-mimicking-malignancy-mesenteric-and-pancreatic-involvement
#15
Mustafa Ozsoy, Zehra Ozsoy, Suleyman Sahin, Yuksel Arıkan
Castleman disease is a lymphoproliferative disorder with unknown etiology and pathogenesis. While the disease may involve all parts of the body, the mediastinum appears to be the most common part of involvement. In this study, we present two cases of Castleman disease with different localizations that mimicked malignancy. A 62-year-old female patient presented with jaundice. Laboratory analysis indicated aspartate aminotransferase: 250 U/L, total bilirubin: 4 mg/dl, and carbohydrate antigen (CA) 19-9: 900 U/ml...
March 12, 2018: Curēus
https://www.readbyqxmd.com/read/29755782/folfirinox-treatment-leading-to-pathologic-complete-response-of-a-locally-advanced-pancreatic-cancer
#16
Andreas Minh Luu, Torsten Herzog, Philipp Hoehn, Anke Reinacher-Schick, Johanna Munding, Waldemar Uhl, Chris Braumann
Pancreatic cancer (PC) is a lethal disease with a poor prognosis. It is typically asymptomatic and therefore most often diagnosed at an advanced stage. A primary unresectable PC can become resectable in case of tumor regression turning palliative into neoadjuvant therapy. We present a 67-year old female patient who was diagnosed with a locally advanced adenocarcinoma of the pancreatic head. After receiving palliative intended chemotherapy with the FOLFIRINOX regimen, staging computed tomography revealed local resectability of the pancreatic head tumor...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29753963/application-of-semi-automated-ultrasonography-on-nutritional-support-for-severe-acute-pancreatitis
#17
Ying Li, Yu Ye, Mei Yang, Haiying Ruan, Yuan Yu
OBJECTIVE: To evaluate the application value of semi-automated ultrasound on the guidance of nasogastrojejunal tube replacement for patients with acute severe pancreatitis (ASP), as well as the value of the nutritional support for standardized treatment in clinical practice. METHODS: The retrospective research was performed in our hospital, and 34 patients suffering from ASP were enrolled into this study. All these identified participants ever received CT scans in order to make definitive diagnoses...
April 25, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29753633/does-mesenteric-venous-imaging-assessment-accurately-predict-pathologic-invasion-in-localized-pancreatic-ductal-adenocarcinoma
#18
Jesse Clanton, Stephen Oh, Stephen J Kaplan, Emily Johnson, Andrew Ross, Richard Kozarek, Adnan Alseidi, Thomas Biehl, Vincent J Picozzi, William S Helton, David Coy, Russell Dorer, Flavio G Rocha
BACKGROUND: Accurate prediction of mesenteric venous involvement in pancreatic ductal adenocarcinoma (PDAC) is necessary for adequate staging and treatment. METHODS: A retrospective cohort study was conducted in PDAC patients at a single institution. All patients with resected PDAC and staging CT and EUS between 2003 and 2014 were included and sub-divided into "upfront resected" and "neoadjuvant chemotherapy (NAC)" groups. Independent imaging re-review was correlated to venous resection and venous invasion...
May 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29752684/natural-history-of-gas-configurations-and-encapsulation-in-necrotic-collections-during-necrotizing-pancreatitis
#19
Janneke van Grinsven, Sandra van Brunschot, Mark C van Baal, Marc G Besselink, Paul Fockens, Harry van Goor, Hjalmar C van Santvoort, Thomas L Bollen
BACKGROUND: Decision-making on invasive intervention in patients with clinical signs of infected necrotizing pancreatitis is often related to the presence of gas configurations and the degree of encapsulation in necrotic collections on imaging. Data on the natural history of gas configurations and encapsulation in necrotizing pancreatitis are, however, lacking. METHODS: A post hoc analysis was performed of a previously described prospective cohort in 21 Dutch hospitals (2004-2008)...
May 11, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29751773/an-unusual-finding-in-a-desmoid-type-fibromatosis-of-the-pancreas-a-case-report-and-review-of-the-literature
#20
Joseph Clarence Torres, Chen Xin
BACKGROUND: Desmoid-type fibromatoses are rare benign and fibrous tumors that account for approximately 0.03% of total neoplasms. Within this category of neoplasms, pancreatic desmoid-type fibromatosis is an extremely rare subgroup, accounting for approximately 5% of desmoid-type fibromatoses. Although the etiology is unknown, some risk factors include trauma, surgery, family history of desmoid tumor, pregnancy, use of contraceptives, genetic mutation, and familial adenomatous polyposis or Gardner syndrome...
May 12, 2018: Journal of Medical Case Reports
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