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https://www.readbyqxmd.com/read/28634684/heterogeneity-index-evaluated-by-slope-of-linear-regression-on-18-f-fdg-pet-ct-as-a-prognostic-marker-for-predicting-tumor-recurrence-in-pancreatic-ductal-adenocarcinoma
#1
Yong-Il Kim, Yong Joong Kim, Jin Chul Paeng, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
PURPOSE: (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been investigated as a method to predict pancreatic cancer recurrence after pancreatic surgery. We evaluated the recently introduced heterogeneity indices of (18)F-FDG PET/CT used for predicting pancreatic cancer recurrence after surgery and compared them with current clinicopathologic and (18)F-FDG PET/CT parameters. METHODS: A total of 93 pancreatic ductal adenocarcinoma patients (M:F = 60:33, mean age = 64...
June 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28634666/ct-density-in-the-pancreas-is-a-promising-imaging-predictor-for-pancreatic-ductal-adenocarcinoma
#2
Yasunari Fukuda, Daisaku Yamada, Hidetoshi Eguchi, Tomoki Hata, Yoshifumi Iwagami, Takehiro Noda, Tadafumi Asaoka, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
BACKGROUND: Fatty pancreas (FP) was recently recognized as a risk factor for pancreatic ductal adenocarcinoma (PDAC). It is unclear whether computed tomography (CT) can be used to make a FP diagnosis. This study investigated whether CT could provide a predictive value for PDAC by diagnosing FP. METHODS: The study included 183 consecutive patients who underwent distal pancreatectomy from February 2007 to January 2017, including 75 cases of PDAC and 108 cases of other pancreatic disease...
June 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28631202/successful-radical-resection-of-pancreatic-head-carcinoma-in-a-patient-with-replaced-right-hepatic-artery-originating-from-posterior-inferior-pancreaticoduodenal-artery-a-case-report
#3
Yusuke Sakamoto, Takahisa Fujikawa, Akira Tanaka
Anatomical variations of hepatic arteries may be problematic in pancreaticoduodenectomy (PD). We experienced pancreatic head cancer in a patient with rare variation of hepatic artery and performed PD successfully with the resection of this artery. A 75-year-old woman showed pancreatic head tumor on CT. Preoperative CT detected rare variation of hepatic artery; posterior segmental branch of right hepatic artery (RHA-PB) originating from posterior inferior pancreaticoduodenal artery. The image also demonstrated that there was a junction between RHA-PB and anterior branch of right hepatic artery (RHA-AB)...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28631148/early-postoperative-imaging-after-non-bariatric-gastric-resection-a-primer-for-radiologists
#4
REVIEW
Massimo Tonolini, Elena Bracchi
Surgical resection represents the mainstay treatment and only potentially curative option for gastric carcinoma, and is increasingly performed laparoscopically. Furthermore, other tumours and selected cases of non-malignant disorders of the stomach may require partial or total gastrectomy. Often performed in elderly patients, gastric resection remains a challenging procedure, with significant morbidity (14-43% complication rate) and non-negligible postoperative mortality (approximately 3%). This paper provides an overview of contemporary surgical techniques for non-bariatric gastric resection, reviews and illustrates the expected postoperative imaging appearances, common and unusual complications after partial and total gastrectomy...
June 19, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28631079/development-of-pancreatic-cancer-is-predictable-well-in-advance-using-contrast-enhanced-ct-a-case-cohort-study
#5
Wataru Gonoi, Takana Yamakawa Hayashi, Hidemi Okuma, Masaaki Akahane, Yousuke Nakai, Suguru Mizuno, Ryosuke Tateishi, Hiroyuki Isayama, Kazuhiko Koike, Kuni Ohtomo
OBJECTIVES: To investigate the radiological findings prognostic for the development of pancreatic adenocarcinoma in a cohort of patients with hepatocellular carcinoma, using multiphasic computed tomography (CT). METHODS: A case-cohort study performed in a single university hospital. A database of patients who received hepatocellular carcinoma (HCC) treatment and trimonthly follow-up with four-phase dynamic CT was used (n = 1848). The cohort group was randomly extracted from the database (n = 103)...
June 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28629416/ct-texture-features-are-associated-with-overall-survival-in-pancreatic-ductal-adenocarcinoma-a-quantitative-analysis
#6
Armin Eilaghi, Sameer Baig, Yucheng Zhang, Junjie Zhang, Paul Karanicolas, Steven Gallinger, Farzad Khalvati, Masoom A Haider
BACKGROUND: To assess whether CT-derived texture features predict survival in patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC). METHODS: Thirty patients with pre-operative CT from 2007 to 2012 for PDAC were included. Tumor size and five texture features namely uniformity, entropy, dissimilarity, correlation, and inverse difference normalized were calculated. Mann-Whitney rank sum test was used to compare tumor with normal pancreas. Receiver operating characteristics (ROC) analysis, Cox regression and Kaplan-Meier tests were used to assess association of texture features with overall survival (OS)...
June 19, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28626371/carcinoma-of-the-papilla-of-vater-after-diversion-operation-for-pancreaticobiliary-maljunction
#7
Takahiro Yamanaka, Kenichiro Araki, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Hiroyuki Kuwano, Ken Shirabe
Pancreaticobiliary maljunction (PBM) is a congenital malformation that is associated with biliary cancer development. When patients are diagnosed with PBM, a diversion operation is recommended. Although a risk remains for developing residual bile duct carcinoma following diversion, the development of a carcinoma of the ampulla of Vater after a diversion operation for PBM is rare. We present a treated case of carcinoma of the ampulla of Vater after a diversion operation for PBM. A 65-year-old woman presented with abdominal pain...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28626263/-11-c-choline-positive-but-18-f-fdg-negative-pancreatic-metastasis-from-renal-cell-carcinoma-on-pet
#8
Kazuhiro Kitajima, Kazuhito Fukushima, Shingo Yamamoto, Takashi Kato, Soichi Odawara, Haruyuki Takaki, Kaoru Kobayashi, Toshiko Yamano, Koichiro Yamakado, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Kazuhiro Suzumura, Etsuro Hatano, Jiro Fujimoto, Takako Kihara, Keiji Nakasho, Seiichi Hirota, Shozo Hirota
Choline is a new PET tracer, which uptake may occur via a choline-specific transporter protein and be accelerated during the proliferation of tumor cells. We report a 61-year-old woman with a metastatic pancreatic tumor from renal cell carcinoma, measuring 35×40 mm. PET scans demonstrated accumulation of (11)C-choline in the metastatic pancreatic tumor, but no accumulation of (18)F-FDG. Choline PET/CT may play a useful and complementary imaging modality, especially when FDG-PET/CT does not show expected findings or when the evaluation of tumor viability is needed, in patients with renal cell carcinoma...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28624923/a-comparison-of-enhancement-patterns-on-dynamic-enhanced-ct-and-survival-between-patients-with-pancreatic-neuroendocrine-tumors-with-and-without-intratumoral-fibrosis
#9
Cherry Kim, Jae Ho Byun, Seung-Mo Hong, Soyeon An, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim
PURPOSE: To compare CT findings and survival between patients with pancreatic neuroendocrine tumors (pNETs) with and without fibrosis. METHODS: Forty-five pNET patients with intratumoral fibrosis (group A) were matched for age, gender, and tumor size and grade with 45 pNET patients without (group B), and CT images were retrospectively reviewed. Hounsfield units (HUs) of tumors in unenhanced, arterial and portal phases, HU ratio (tumor to normal parenchyma) in each phase, enhancement patterns, visible enhancement pattern changes, and survival were compared...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28624015/imaging-modalities-in-the-diagnosis-of-pancreatic-adenocarcinoma-a-systematic-review-and-meta-analysis-of-sensitivity-specificity-and-diagnostic-accuracy
#10
James Toft, William J Hadden, Jerome M Laurence, Vincent Lam, Lawrence Yuen, Anna Janssen, Henry Pleass
BACKGROUND: Pancreatic cancer, primarily pancreatic ductal adenocarcinoma (PDAC), accounts for 2.4% of cancer diagnoses and 5.8% of cancer death annually. Early diagnoses can improve 5-year survival in PDAC. The aim of this systematic review was to determine the sensitivity, specificity and diagnostic accuracy values for MRI, CT, PET&PET/CT, EUS and transabdominal ultrasound (TAUS) in the diagnosis of PDAC. METHODS: A systematic review was undertaken to identify studies reporting sensitivity, specificity and/or diagnostic accuracy for the diagnosis of PDAC with MRI, CT, PET, EUS or TAUS...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28621885/multiagent-induction-chemotherapy-followed-by-chemoradiation-is-associated-with-improved-survival-in-locally-advanced-pancreatic-cancer
#11
Anna Torgeson, Shane Lloyd, Dustin Boothe, Randa Tao, Jonathan Whisenant, Ignacio Garrido-Laguna, George M Cannon
BACKGROUND: The role of chemoradiotherapy (CRT) in locally advanced pancreatic cancer (LAPC) is uncertain after multiple randomized clinical trials have yielded mixed results. The authors used the National Cancer Database (NCDB) to determine whether CRT yields a survival benefit compared with chemotherapy alone (CT). METHODS: Patients with nonmetastatic LAPC diagnosed during 2004 through 2014 were identified in the NCDB. Patients who received CT were compared with those who received CRT using chi-square analysis...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28619284/assessment-of-disease-aggression-in-cystic-pancreatic-neuroendocrine-tumors-a-ct-and-pathology-correlation-study
#12
Motoyo Yano, Sunil Misra, Amber Salter, Danielle H Carpenter
BACKGROUND/OBJECTIVES: There are inconsistencies in the literature regarding the clinical significance of cystic components in pancreatic neuroendocrine tumors (NET). This may be related to differences in the identification of cystic NET through imaging and/or pathology. Tumors may also be microscopically or macroscopically cystic. Our primary objective is to determine radiology-pathology correlation for the identification of cystic components. Our secondary objective is to determine if cystic components are associated with indices of tumor aggression...
May 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28616240/metastatic-pancreatic-carcinoma-masquerading-as-cystic-lung-disease-a-rare-presentation
#13
Emily Stern, Taha Huseini, YiJin Kuok, Fiona Lake
This 52-year-old male ex-smoker presented with a six-month history of progressive breathlessness and weight loss. He deteriorated acutely, and was admitted with severe type 1 respiratory failure. Apart from diffuse coarse crackles on chest auscultation, physical examination was unremarkable. High-resolution computed tomography (HRCT) showed diffuse cystic changes throughout the lungs. A diagnosis of pulmonary Langerhans cell histiocytosis (PLCH) was considered. Further workup identified a coincidental pancreatic lesion of uncertain significance, which remained indeterminate on magnetic resonance imaging (MRI) and on positron emission tomography (PET)...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28614269/comparison-of-preoperative-imaging-and-pathological-findings-for-pancreatic-head-adenocarcinoma-a-retrospective-analysis-by-the-association-fran%C3%A3-aise-de-chirurgie
#14
Marine Gilabert, Jean-Marie Boher, Jean-Luc Raoul, François Paye, Philippe Bachellier, Olivier Turrini, Jean Robert Delpero
Initial imaging of pancreatic ductal adenocarcinoma is of crucial importance in the decision-making process. The aim of this study was to compare preoperative imaging, pathological data, and outcomes in a series of patients who underwent resection for pancreatic head cancer.From January 2004 to December 2009, data were collected by the Association Française de Chirurgie on 1044 patients who received first-line R0 resection of pancreatic head cancer.On imaging (computed tomography scan 97%, echoendoscopic ultrasound 61...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28611634/a-case-of-noncuratively-resected-gastric-cancer-and-postoperative-chemotherapy-with-s-1-monotherapy-resulting-in-long-term-survival-for-over-8-years
#15
Byoung Jo Suh
We report the case of a noncuratively resected gastric cancer patient who was successfully treated with S-1 monotherapy, resulting in long-term survival of 96 months. A 72-year-old woman underwent noncurative resection of subtotal gastrectomy for advanced gastric cancer with conglomerated lymph node metastasis and pancreatic invasion. She received chemotherapy with S-1 monotherapy postoperatively. S-1 (100 mg/day) was administered orally after breakfast and dinner for 28 days followed by a 14-day break for a total of 52 months...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28611527/successful-treatment-of-a-pancreatic-schwannoma-by-spleen-preserving-distal-pancreatectomy
#16
Shao-Yan Xu, Ying-Sheng Wu, Jian-Hui Li, Ke Sun, Zhen-Hua Hu, Shu-Sen Zheng, Wei-Lin Wang
Schwannomas are neurogenic tumors that arise from the neural sheaths of peripheral nerves. These tumors can be located in any area of the human body; the most common locations are the head, neck, trunk and extremities. Pancreatic schwannomas are very rare. Over the past 40 years, only 67 cases of pancreatic schwannomas have been reported in the English literature. Here we present a case of pancreatic schwannoma in a 62-year-old male. The tumor was revealed by ultrasound and computed tomography in the neck and body of the pancreas...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28611200/dendritic-cell-cytokine-induced-killer-cell-immunotherapy-combined-with-s-1-in-patients-with-advanced-pancreatic-cancer-a-prospective-study
#17
Ni Jiang, Guoliang Qiao, Xiao-Li Wang, Michael A Morse, William R Gwin, Lei Zhou, Yuguang Song, Yanjie Zhao, Feng Chen, Xin-Na Zhou, Lefu Huang, Amy Hobeika, Xin Yi, Xuefeng Xia, Yanfang Guan, Jin Song, Jun Ren, H Kim Lyerly
Purpose: Advanced pancreatic cancer has remained challenging to treat effectively. This study aimed to investigate the clinical effects and safety of immunotherapy with dendritic cells and cytokine induced killer cells (DC-CIK) administered with the chemotherapy (CT) S-1 in this malignancy. <p> Experimental Design: Consecutive patients (n=47) with advanced pancreatic cancer were treated with either DC-CIK + S-1, DC-CIK alone, S-1 alone, or best supportive care.</p> <p> Results: DC-CIK plus S-1 produced significantly longer median OS and PFS (212 and 136 days) compared with DC-CIK (128 and 85 days), CT (141 and 92 days) or supportive care only (52 and 43 days) (P<0...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28609376/the-role-of-abdominal-computed-tomography-scan-in-acute-pancreatitis
#18
Ahmed Al-Khazraji, Ahmed Q Hasan, Ishan Patel, Hassan Alkhawam, Fadi Ghrair, Joseph Lieber
No abstract text is available yet for this article.
July 2017: Pancreas
https://www.readbyqxmd.com/read/28609373/multiorgan-failure-predicts-mortality-in-emphysematous-pancreatitis-a-case-report-and-systematic-analysis-of-the-literature
#19
Vadim Bul, Cemal Yazici, Jonas J Staudacher, Barbara Jung, Brian R Boulay
Emphysematous pancreatitis (EP) is a subtype of acute necrotizing pancreatitis (ANP) characterized by the presence of gas in and around the pancreas. Although investigators have studied prognostic factors in ANP, less is known about EP. We aimed to determine predictors of mortality and identify changes in management strategies for EP. A PubMed search was performed to identify EP cases. Data were gathered about patient demographics, clinical findings, laboratory results, radiological studies, procedures, outcomes, and mortality...
July 2017: Pancreas
https://www.readbyqxmd.com/read/28609366/visceral-adiposity-predicts-severity-of-acute-pancreatitis
#20
Ashwinee Natu, Tyler Stevens, Lorna Kang, Scott Yasinow, Emad Mansoor, Rocio Lopez, Brooke Glessing, Erick Remer, Tyler Richards, Amit Gupta, Amitabh Chak, Peter J W Lee
OBJECTIVES: The aim of this study was to determine the association of visceral adiposity with severe outcomes in acute pancreatitis (AP). METHODS: This retrospective study included consecutive patients with AP admitted to a tertiary care hospital between January 2010 and January 2015 who underwent a computed tomography scan. The visceral adipose tissue (VAT) volume was estimated using the method of Linder and colleagues. Multivariable logistic regression analysis was conducted to assess VAT as a predictor of severe AP compared with other validated predictors of severity...
July 2017: Pancreas
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