keyword
https://read.qxmd.com/read/38490841/clinical-and-ct-quantitative-features-for-predicting-liver-metastases-in-patients-with-pancreatic-neuroendocrine-tumors-a-study-with-prospective-external-validation
#1
JOURNAL ARTICLE
Yao Pan, Hai-Yan Chen, Jie-Yu Chen, Xiao-Jie Wang, Jia-Ping Zhou, Lei Shi, Ri-Sheng Yu
RATIONALE AND OBJECTIVES: We aimed to evaluate clinical characteristics and quantitative CT imaging features for the prediction of liver metastases (LMs) in patients with pancreatic neuroendocrine tumors (PNETs). METHODS: Patients diagnosed with pathologically confirmed PNETs were included, 133 patients were in the training group, 22 patients in the prospective internal validation group, and 28 patients in the external validation group. Clinical information and quantitative features were collected...
March 14, 2024: Academic Radiology
https://read.qxmd.com/read/38486974/large-epidermoid-cyst-of-the-spleen-causing-massive-splenomegaly-a-case-report
#2
Deshan Mario Gomez, Sivasuriya Sivaganesh
Splenic cysts are uncommon and are classified as primary cysts or secondary cysts based on the presence or absence of an intact epithelial lining, respectively. Epidermoid cysts have an epithelial lining of stratified squamous epithelium and have been reported in normal and intra-pancreatic accessory spleens. An 18-year-old girl presented with a symptomatic, uncomplicated splenic cyst causing massive splenomegaly and symptoms due to mass effect. Peripheral cytopaenias and lymphoproliferative neoplasm were excluded...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38486100/preserving-fairness-and-diagnostic-accuracy-in-private-large-scale-ai-models-for-medical-imaging
#3
JOURNAL ARTICLE
Soroosh Tayebi Arasteh, Alexander Ziller, Christiane Kuhl, Marcus Makowski, Sven Nebelung, Rickmer Braren, Daniel Rueckert, Daniel Truhn, Georgios Kaissis
BACKGROUND: Artificial intelligence (AI) models are increasingly used in the medical domain. However, as medical data is highly sensitive, special precautions to ensure its protection are required. The gold standard for privacy preservation is the introduction of differential privacy (DP) to model training. Prior work indicates that DP has negative implications on model accuracy and fairness, which are unacceptable in medicine and represent a main barrier to the widespread use of privacy-preserving techniques...
March 14, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38483105/quantitative-t2-mapping-of-acute-pancreatitis
#4
JOURNAL ARTICLE
Fabio Porões, Naïk Vietti Violi, Giulia Piazza, Emilie Uldry, Enrique Lázaro-Fontanet, Sérgio Gaspar-Figueiredo, Tom Hilbert, Jean-Baptiste Ledoux, Alban Denys, Frédéric Schütz, Sabine Schmidt
BACKGROUND: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable assessment of AP. PURPOSE: To evaluate MR-derived pancreatic T2 mapping values in AP and correlate them with markers of disease severity. STUDY TYPE: Prospective single-center study. POPULATION: 76 adults with AP (20-91 years, females/males: 39/37)...
March 14, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38482094/the-diagnostic-yield-of-endoscopic-ultrasound-in-asymptomatic-patients-with-unexplained-dilated-common-bile-duct-or-double-duct-sign-with-normal-transaminase-a-retrospective-study-from-a-single-urban-based-university-endoscopy-center
#5
JOURNAL ARTICLE
Mina F Alkomos, Shaker Barham, Youssef Botros, Nader Mekheal, Ariana Tagliaferri, Alisa Farokhian, Hardikkumar M Shah, Gabriel Melki, Yana Cavanagh, Walid Baddoura, Matthew Grossman
BACKGROUND: Common bile duct dilatation alone or double duct sign (both CBD and dilated pancreatic duct dilatation) and abnormal liver enzymes are highly predictive of biliary disease. This can be identified on ultrasound (US), CT scan, and/or magnetic resonance cholangiopancreatography (MRCP). Unexplained dilatation on imaging might warrant endoscopic ultrasound (EUS) to identify any occult causes. Supporting literature about the importance of using EUS in these conditions is evolving with no clear evidence-based approach to evaluate asymptomatic dilated ducts...
2024: Journal of Community Hospital Internal Medicine Perspectives
https://read.qxmd.com/read/38481922/extranodal-anaplastic-large-cell-lymphoma-involving-the-pancreas-a-rare-presentation
#6
Haifa N Alsaleem, Ahmed S Almuzaini, Khaled Alnafisah, Nawaf Almutairi, Ammar M ALAmmari, Ahmed S AlOmar
Anaplastic large-cell lymphoma (ALCL) is a subtype of T-cell lymphoma. This disease mainly affects lymph nodes, although extranodal sites may also be involved. Lymphoma in the pancreas is a rare clinical entity whether it manifests as primary or extranodal involvement. We discuss an unusual case of a 29-year-old male patient who presented with epigastric pain and a right neck mass. The patient's symptoms, physical examination, and laboratory tests prompted further investigation using imaging modalities such as CT, MRI, and endoscopic ultrasound, which revealed the presence of soft tissue masses in the right supraclavicular region and an ill-defined lesion within the pancreatic head...
February 2024: Curēus
https://read.qxmd.com/read/38478039/pancreatic-congenital-anomalies-and-their-features-on-ct-and-mr-imaging-a-pictorial-review
#7
REVIEW
Gary Amseian, Juan-Ramón Ayuso
OBJECTIVE: To review the congenital anomalies of the pancreas with their main clinical manifestations and key imaging findings on CT and MRI. BACKGROUND AND CLINICAL SIGNIFICANCE: Anomalies of pancreatic development are frequent and generally asymptomatic, but can mimic and predispose individuals to pancreatic or peripancreatic pathologies, such as pancreatitis or malignancy. Their correct diagnosis may help avoid unnecessary further investigations and procedures, or establish adequate treatment when they manifest clinically...
March 13, 2024: Abdominal Radiology
https://read.qxmd.com/read/38478012/feasibility-estimation-of-injected-hydrodissection-before-definitive-radiotherapy-of-pancreatic-adenocarcinoma
#8
JOURNAL ARTICLE
Yuan-Hung Wu, Shu-Huei Shen, Yen-Po Wang, Nai-Wen Chang, Pei-Chang Lee, Chung-Pin Li, Keng-Li Lan, Cheng-Yin Shiau, Yu-Wen Hu, Pin-I Huang, Chen-Xiong Hsu, Sang-Hue Yen, Shih-Ming Hsu
BACKGROUND: Pancreatic adenocarcinoma is often not diagnosed until an advanced stage, and so most patients are not eligible for resection. For patients who are inoperable, definitive radiotherapy is crucial for local disease control. However, the pancreas is located close to other vulnerable gastrointestinal organs, making it challenging to deliver an adequate radiation dose. The surgical insertion of spacers or injection of fluids such as hydrogel before radiotherapy has been proposed, however no study has discussed which patients are suitable for the procedure...
March 13, 2024: Journal of the Chinese Medical Association: JCMA
https://read.qxmd.com/read/38476780/role-of-endoscopic-ultrasound-in-staging-and-vascular-assessment-of-pancreatic-cancer
#9
JOURNAL ARTICLE
Mohammed A El-Nady, Khalid A Ead, Mustafa A Haridy, Nour Shaheen, Abdulqadir J Nashwan, Saad R Abdelwahid, Mohammed F Mohammed, Omran Mohamed, Safwat S Sawy, Emad Abdelrazzak, Amro M Hassan
Introduction Computed tomography (CT) of the abdomen with contrast stands as the gold standard for assessing pancreatic cancer, encompassing both staging and vascular analysis. However, not all patients are suitable candidates for contrast-enhanced CT (CECT) scans due to factors such as contrast agent allergies, pregnancy, renal impairment, radiation risks, and limited tissue sampling capability in CECT scans of the abdomen. In light of these challenges, this study evaluated the diagnostic capabilities of endoscopic ultrasound (EUS) compared to CECT for staging and vascular assessment of pancreatic cancer...
February 2024: Curēus
https://read.qxmd.com/read/38472447/ct-based-pancreatic-radiomics-predicts-secondary-loss-of-response-to-infliximab-in-biologically-na%C3%A3-ve-patients-with-crohn-s-disease
#10
JOURNAL ARTICLE
Tian Yang, Jing Feng, Ruchen Yao, Qi Feng, Jun Shen
OBJECTIVES: Predicting secondary loss of response (SLR) to infliximab (IFX) is paramount for tailoring personalized management regimens. Concurrent pancreatic manifestations in patients with Crohn's disease (CD) may correlate with SLR to anti-tumor necrosis factor treatment. This work aimed to evaluate the potential of pancreatic radiomics to predict SLR to IFX in biologic-naive individuals with CD. METHODS: Three models were developed by logistic regression analyses to identify high-risk subgroup prone to SLR...
March 13, 2024: Insights Into Imaging
https://read.qxmd.com/read/38471465/heterogeneity-of-multiple-pancreatic-neuroendocrine-tumors-identified-by-68ga-dotanoc-and-68ga-exendin-4-pet-ct-in-a-patient-with-endogenous-hyperinsulinemic-hypoglycemia-and-multiple-endocrine-neoplasia-1
#11
Junyan Xu, Xiaoping Xu, Meng Zhang, Wensheng Liu, Jie Chen, Shaoli Song
Insulinomas are the most frequent functional neuroendocrine tumors of pancreas. In about 10% cases, insulinomas are associated with hereditary syndrome including multiple endocrine neoplasia 1 (MEN1). Herein, we presented a case of 44-year-old female with recurrent hypoglycemia. In December 1998, this patient has undergone resection of two pancreatic lesions due to hypoglycemia and diagnosed as insulinoma. After operation, the symptom of hypoglycemia disappeared. However, from 2021, hypoglycemic symptoms reappeared frequently and even coma...
March 12, 2024: Neuroendocrinology
https://read.qxmd.com/read/38470348/synthesis-and-preclinical-evaluation-of-bold-100-radiolabeled-with-ruthenium-97-and-ruthenium-103
#12
JOURNAL ARTICLE
B Happl, T Balber, P Heffeter, C Denk, J M Welch, U Köster, C Alliot, A-C Bonraisin, M Brandt, F Haddad, J H Sterba, W Kandioller, M Mitterhauser, M Hacker, B K Keppler, T L Mindt
BOLD-100 (formerly IT-139, KP1339), a well-established chemotherapeutic agent, is currently being investigated in clinical trials for the treatment of gastric, pancreatic, colorectal, and bile duct cancer. Despite numerous studies, the exact mode of action is still the subject of discussions. Radiolabeled BOLD-100 could be a powerful tool to clarify pharmacokinetic pathways of the compound and to predict therapy responses in patients using nuclear molecular imaging prior to the therapy. In this study, the radiosyntheses of carrier-added (c...
March 12, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38469012/acute-necrotizing-pancreatitis-presenting-as-gastrocolic-fistula-a-rare-occurrence
#13
Twinkle Pawar, Harshitha Reddy, Sunil Kumar, Sourya Acharya, Vijendra Kirnake
Tissue necrosis and ischemia are hallmarks of acute necrotizing pancreatitis, which frequently results in fatal infections. In this case, we describe a man in his 40s who had diffuse pain in the abdomen, intractable vomiting, diarrhoea, and intermittent fever. His abdominal computed tomography revealed acute pancreatitis with peripancreatic fluid collection, gastric perforation, and fistula formation between the greater curvature of the stomach and transverse colon. His upper gastrointestinal (GI) endoscopy confirmed a gastrocolic fistula...
February 2024: Curēus
https://read.qxmd.com/read/38468391/feasibility-of-proton-dosimetry-overriding-planning-ct-with-daily-cbct-elaborated-through-generative-artificial-intelligence-tools
#14
JOURNAL ARTICLE
Matteo Rossi, Gabriele Belotti, Luca Mainardi, Guido Baroni, Pietro Cerveri
Radiotherapy commonly utilizes cone beam computed tomography (CBCT) for patient positioning and treatment monitoring. CBCT is deemed to be secure for patients, making it suitable for the delivery of fractional doses. However, limitations such as a narrow field of view, beam hardening, scattered radiation artifacts, and variability in pixel intensity hinder the direct use of raw CBCT for dose recalculation during treatment. To address this issue, reliable correction techniques are necessary to remove artifacts and remap pixel intensity into Hounsfield Units (HU) values...
December 2024: Computer Assisted Surgery (Abingdon, England)
https://read.qxmd.com/read/38465467/total-lesion-glycolysis-by-18-f-fluorodeoxyglucose-positron-emission-tomography-predicts-tumor-aggressiveness-in-patients-with-extrahepatic-bile-duct-carcinoma
#15
JOURNAL ARTICLE
Ryosuke Fukushima, Norifumi Harimoto, Shunsuke Kawai, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Kenichiro Araki, Hiroyasu Tomonaga, Tetsuya Higuchi, Ken Shirabe
BACKGROUND: 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) parameters are prognostic factors in multiple malignancies. However, the prognostic value in bile duct carcinoma is unclear. We evaluated the impact of metabolic parameters of 18 F-FDG-PET/CT in resectable extrahepatic bile duct carcinoma. METHODS: We retrospectively reviewed the records of 100 patients with extrahepatic bile duct carcinoma who had undergone 18 F-FDG-PET/CT and subsequent surgical resection between January 2017 and January 2023...
March 11, 2024: Journal of Hepato-biliary-pancreatic Sciences
https://read.qxmd.com/read/38465285/polymicrobial-purulent-pericarditis-from-a-pancreatico-pericardial-fistula
#16
JOURNAL ARTICLE
Christopher Richardson, Mark Cromer, Luis Tatem, Raymond Wade, Derek Russell
A 54-year-old male with chronic pancreatitis presented with dyspnea. Computed tomography scans demonstrated a subdiaphragmatic fluid collection with pericardial fistulization. Pericardial fluid cultures were polymicrobial in nature. Purulent pericarditis is rare but carries a high mortality rate. We present the first documented case of pancreatico-pericardial fistulization causing purulent pericarditis.
April 3, 2024: JACC. Case reports
https://read.qxmd.com/read/38464982/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-and-fine-needle-biopsy-to-generate-pancreatic-cancer-organoids-randomized-trial
#17
JOURNAL ARTICLE
Johannes Roman Wiessner, Felix Orben, Arlett Schäfer, Lisa Fricke, Günter Schneider, Maximilian Reichert, Alexander Herner, Ulrich Mayr, Veit Phillip, Matthias Treiber, Guido von Figura, Mohamed Abdelhafez, Roland M Schmid, Christoph Schlag
Background and study aims The prognosis for pancreatic cancer remains poor. Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model systems such as organoids have the potential to substantially increase the depth of information from biopsy material by functional and molecular characterization. We compared the extent to which the use of fine-needle aspiration needles (FNA, 22G) or fine-needle biopsy needles (FNB, 22G) influences the generation of pancreatic cancer patient-derived organoids (PDOs) to establish endoscopic standards of organoid technology...
March 2024: Endoscopy International Open
https://read.qxmd.com/read/38463732/microcystic-serous-cystadenoma-of-the-pancreas-causing-biliary-obstruction-a-case-report-and-review-of-the-literature
#18
Sydney Bland, William Thompson Iii
Cystic tumors account for 15% of pancreatic tumors. Of these, serous microcystic adenomas represent 1-2% of pancreatic exocrine neoplasms. While typically benign, a small percentage possess malignant potential. Given imaging improvements, serous cystadenomas are being identified more frequently. A 63-year-old female was admitted with complaints of jaundice and unintentional weight loss. Abdominal computed tomography scan showed a 16 cm obstructive pancreatic mass near the porta hepatis region. Endoscopic ultrasonography and fine needle aspiration biopsy indicated a large pancreatic head cystic mass favoring serous microcystadenoma causing biliary and some pyloric obstruction...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38463493/-18-f-fdg-pet-ct-assists-the-diagnosis-of-primary-pancreatic-lymphoma-two-case-reports-and-literature-review
#19
Jian Wang, Yujing Zhou, Hongwei Liu, Jianli Zhou, Xin Li
Primary pancreatic lymphoma (PPL) is a rare malignancy, which is defined as a mass centered in pancreas with involvement of contiguous lymph nodes and distant spread may exist. Accurate diagnosis of PPL prior to pathological confirmation remains challenging, underscoring the critical significance of preoperative imaging assessments. This case report collected two instances of PPL that underwent initial evaluation via 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) between August 2021 and July 2022...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38463375/early-endoscopic-management-of-an-infected-acute-necrotic-collection-misdiagnosed-as-a-pancreatic-pseudocyst-a-case-report
#20
Hong-Ying Zhang, Chen-Cong He
BACKGROUND: Infected acute necrotic collection (ANC) is a fatal complication of acute pancreatitis with substantial morbidity and mortality. Drainage plays an exceedingly important role as the first step in invasive intervention for infected necrosis; however, there is great controversy about the optimal drainage time, and better treatment should be explored. CASE SUMMARY: We report the case of a 43-year-old man who was admitted to the hospital with severe intake reduction due to early satiety 2 wk after treatment for acute pancreatitis; conservative treatment was ineffective, and a pancreatic pseudocyst was suspected on contrast-enhanced computed tomography (CT)...
February 27, 2024: World Journal of Gastrointestinal Surgery
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