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https://www.readbyqxmd.com/read/27899706/mixed-hidden-markov-quantile-regression-models-for-longitudinal-data-with-possibly-incomplete-sequences
#1
Maria Francesca Marino, Nikos Tzavidis, Marco Alfò
Quantile regression provides a detailed and robust picture of the distribution of a response variable, conditional on a set of observed covariates. Recently, it has be been extended to the analysis of longitudinal continuous outcomes using either time-constant or time-varying random parameters. However, in real-life data, we frequently observe both temporal shocks in the overall trend and individual-specific heterogeneity in model parameters. A benchmark dataset on HIV progression gives a clear example. Here, the evolution of the CD4 log counts exhibits both sudden temporal changes in the overall trend and heterogeneity in the effect of the time since seroconversion on the response dynamics...
November 28, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27898550/severe-intraoperative-shock-related-to-mesenteric-traction-syndrome
#2
Alfredo Haack Couto, Hugo Siqueira, Pablo Pulcheira Brasileiro, Ismar Lima Cavalcanti, Rogério Luiz da Rocha Videira
Mesenteric traction syndrome is defined as arterial hypotension, facial flushing, and tachycardia related to mesenteric traction. We describe a case of mesenteric traction syndrome refractory to catecholamine and vasopressin infusions. The patient, who had Crohn disease, developed severe distributive shock after mesenteric traction while undergoing resection of an intestinal inflammatory mass, accompanied by facial flushing and unaltered readings for pulse oximetry, capnography, and bispectral index monitoring...
November 28, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27897369/double-side-cocatalytic-activation-of-anodic-tio2-nanotube-membranes-with-sputter-coated-pt-for-photocatalytic-h2-generation-from-water-ethanol-mixtures
#3
Gihoon Cha, Marco Altomare, Nhat Truong Nguyen, Nicola Taccardi, Kiyoung Lee, Patrik Schmuki
Self-standing TiO2 nanotube layers in the form of membranes are fabricated by self-organizing anodization of Ti metal and a potential shock technique. The membranes were then decorated by sputtering different Pt amounts i) only at the top, ii) only at the bottom or iii) at both top and bottom of the tube layers. The Pt-decorated membranes are transferred either in tube top up or in tube top down configuration onto FTO slides and investigated after crystallization as photocatalysts for H2 generation using either front or back-side light irradiation...
November 29, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27892963/stress-wave-propagation-in-two-dimensional-buckyball-lattice
#4
Jun Xu, Bowen Zheng
Orderly arrayed granular crystals exhibit extraordinary capability to tune stress wave propagation. Granular system of higher dimension renders many more stress wave patterns, showing its great potential for physical and engineering applications. At nanoscale, one-dimensionally arranged buckyball (C60) system has shown the ability to support solitary wave. In this paper, stress wave behaviors of two-dimensional buckyball (C60) lattice are investigated based on square close packing and hexagonal close packing...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890439/a-japanese-nationwide-multicenter-survey-on-perioperative-complications-of-corrective-fusion-for-elderly-patients-with-adult-spinal-deformity
#5
Yu Yamato, Yukihiro Matsuyama, Kazuhiro Hasegawa, Yoichi Aota, Tsutomu Akazawa, Takahiro Iida, Kazumasa Ueyama, Koki Uno, Tokumi Kanemura, Noriaki Kawakami, Toshiaki Kotani, Masashi Takaso, Jun Takahashi, Masato Tanaka, Hiroshi Taneichi, Taichi Tsuji, Hideo Hosoe, Joji Mochida, Takachika Shimizu, Ikuho Yonezawa, Kota Watanabe, Morio Matsumoto
BACKGROUND: Recently, corrective fusion surgery for patients with adult spinal deformity (ASD) has become common in Japan. This study aimed to clarify the status of surgeries for ASD in Japan, focusing on perioperative complications. A nationwide multicenter survey gathering information on surgically treated ASD patients was conducted by the committee for Adult Spinal Deformity of the Japanese Scoliosis Society. METHODS: This study was a review of retrospectively collected data from 18 spine scoliosis centers belonging to the Japanese Scoliosis Society...
November 24, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27876077/post-traumatic-acute-kidney-injury-a-cross-sectional-study-of-trauma-patients
#6
Wei-Hung Lai, Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Pao-Jen Kuo, Shiun-Yuan Hsu, Ching-Hua Hsieh, Hsiao-Yun Hsieh
BACKGROUND: The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock at a Level I trauma center. METHODS: Detailed data of 78 trauma patients with AKI and 14,504 patients without AKI between January 1, 2009 and December 31, 2014 were retrieved from the Trauma Registry System...
November 22, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27874920/m%C3%A3-n-har-b%C3%A3-ttre-intensivv%C3%A3-rds%C3%A2-%C3%A3-verlevnad-%C3%A3-n-kvinnor-g%C3%A3-ller-fr%C3%A3-mst-diagnoser-som-hj%C3%A3-rtstopp-och-septisk-chock
#7
Hanna Nyberg, Carolina Samuelsson, Attila Frigyesi
Better intensive care outcomes for men than women especially in septic shock and after cardiac arrest In this study 11 764 intensive care admissions to Skåne University Hospital in Sweden between 2008 and 2015 were studied for any gender differences in outcome for different diagnoses. As known from previous studies, men had more intensive care admissions and had a higher morbidity necessitating the use of risk adjusted mortality measures. Through a simple but new application of VLAD we found this risk-adjusted mortality measure to be more sensitive in detecting differences in mortality between groups than the more commonly used SMR...
November 15, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27872278/reconstitution-of-a-mycobacterium-tuberculosis-proteostasis-network-highlights-essential-cofactor-interactions-with-chaperone-dnak
#8
Tania J Lupoli, Allison Fay, Carolina Adura, Michael S Glickman, Carl F Nathan
During host infection, Mycobacterium tuberculosis (Mtb) encounters several types of stress that impair protein integrity, including reactive oxygen and nitrogen species and chemotherapy. The resulting protein aggregates can be resolved or degraded by molecular machinery conserved from bacteria to eukaryotes. Eukaryotic Hsp104/Hsp70 and their bacterial homologs ClpB/DnaK are ATP-powered chaperones that restore toxic protein aggregates to a native folded state. DnaK is essential in Mycobacterium smegmatis, and ClpB is involved in asymmetrically distributing damaged proteins during cell division as a mechanism of survival in Mtb, commending both proteins as potential drug targets...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27857954/heat-stress-gastrointestinal-permeability-and-interleukin-6-signaling-implications-for-exercise-performance-and-fatigue
#9
REVIEW
Nicole Vargas, Frank Marino
Exercise in heat stress exacerbates performance decrements compared to normothermic environments. It has been documented that the performance decrements are associated with reduced efferent drive from the central nervous system (CNS), however, specific factors that contribute to the decrements are not completely understood. During exertional heat stress, blood flow is preferentially distributed away from the intestinal area to supply the muscles and brain with oxygen. Consequently, the gastrointestinal barrier becomes increasingly permeable, resulting in the release of lipopolysaccharides (LPS, endotoxin) into the circulation...
April 2016: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27853553/the-role-of-three-heat-shock-protein-genes-in-the-immune-response-to-aeromonas-hydrophila-challenge-in-marbled-eel-anguilla-marmorata
#10
Fenfei Liang, Guosong Zhang, Shaowu Yin, Li Wang
Heat shock proteins (HSPs) are highly conserved molecular chaperones that play critical roles in both innate and adaptive immunity. However, little information about HSPs from marbled eel Anguilla marmorata is known. In this study, the full-length Amhsp90 (2527 bp), Amhsp70 (2443 bp) and Amhsc70 (2247 bp) were first cloned from A. marmorata, using rapid amplification of cDNA ends, containing open reading frames of 2181, 1932 and 1950 bp in length, and encoding proteins with 726, 643 and 649 amino acids, respectively...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27851947/time-course-statistical-evaluation-of-intercellular-adhesion-maturation-by-femtosecond-laser-impulse
#11
Takanori Iino, Man Hagiyama, Tadahide Furuno, Akihiko Ito, Yoichiroh Hosokawa
The maturation of intercellular adhesion is an essential process for establishing the signal transduction network in living cells. Although the maturation is naturally considered to enhance the signal transduction, the relationship between the signal transduction and the maturation process has not been revealed in detail using time-course data. Here, using a coculture of mast cells and neurites, differences in maturation between individual cells were estimated as a function of the adhesion strength by our original single-cell measurement method utilizing a laser-induced impulsive force...
November 15, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27851363/1728-refractory-and-progressive-distributive-shock-due-to-angioimmunoblastic-t-cell-lymphoma
#12
Dan Reynolds, Hemang Yadav
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851261/1626-mixed-obstructive-and-distributive-shock-from-empyema
#13
Avraham Cooper, Daniel Adams, Adam Mahoney, Maria Lucarelli
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27832458/proteomic-profiles-reveal-the-function-of-different-vegetative-tissues-of-moringa-oleifera
#14
Lei Wang, Qiong Zou, Jinxing Wang, Junjie Zhang, Zeping Liu, Xiaoyang Chen
Moringa oleifera is a rich source of bioactive compounds and is widely used in traditional medicine and food for its nutritional value; however, the protein and peptide components of different tissues are rarely discussed. Here, we describe the first investigation of M. oleifera proteomes using mass spectrometry and bioinformatics methods. We aimed to elucidate the protein profiles of M. oleifera leaves, stem, bark, and root. Totally 202 proteins were identified from four vegetative organs. We identified 101 proteins from leaves, 51 from stem, 94 from bark and 67 from root, finding that only five proteins existed in both four vegetative parts...
December 2016: Protein Journal
https://www.readbyqxmd.com/read/27832122/inducing-cold-sensitivity-in-the-frigophilic-fly-drosophila-montana-by-rnai
#15
Felipe M Vigoder, Darren J Parker, Nicola Cook, Océane Tournière, Tanya Sneddon, Michael G Ritchie
Cold acclimation is a critical physiological adaptation for coping with seasonal cold. By increasing their cold tolerance individuals can remain active for longer at the onset of winter and can recover more quickly from a cold shock. In insects, despite many physiological studies, little is known about the genetic basis of cold acclimation. Recently, transcriptomic analyses in Drosophila virilis and D. montana revealed candidate genes for cold acclimation by identifying genes upregulated during exposure to cold...
2016: PloS One
https://www.readbyqxmd.com/read/27820595/the-relationship-between-index-hospitalizations-sepsis-and-death-or-transition-to-hospice-care-during-30-day-hospital-readmissions
#16
Brett W Dietz, Tiffanie K Jones, Dylan S Small, David F Gaieski, Mark E Mikkelsen
BACKGROUND: Hospital readmissions are common, expensive, and increasingly used as a metric for assessing quality of care. The relationship between index hospitalizations and specific outcomes among those readmitted remains largely unknown. OBJECTIVES: Identify risk factors present during the index hospitalization associated with death or transition to hospice care during 30-day readmissions and examine the contribution of infection in readmissions resulting in death...
November 4, 2016: Medical Care
https://www.readbyqxmd.com/read/27818784/red-cell-distribution-width-and-mortality-in-acute-heart-failure-patients-with-preserved-and-reduced-ejection-fraction
#17
Konstantinos Sotiropoulos, Patrick Yerly, Pierre Monney, Antoine Garnier, Julien Regamey, Olivier Hugli, David Martin, Melanie Metrich, Jean-Philippe Antonietti, Roger Hullin
BACKGROUND: Elevated red blood cell distribution width (RDW) is a valid predictor of outcome in acute heart failure (AHF). It is unknown whether elevated RDW remains predictive in AHF patients with either preserved left ventricular ejection fraction (LVEF) ≥50% or reduced LVEF (<50%). METHODS AND RESULTS: Prospective local registry including 402 consecutive hospitalized AHF patients without acute coronary syndrome or need of intensive care. The primary outcome was all-cause mortality (ACM) at 1 year after admission...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27806910/structure-and-function-of-pspa-and-vipp1-n-terminal-peptides-insights-into-the-membrane-stress-sensing-and-mitigation
#18
Christopher McDonald, Goran Jovanovic, B A Wallace, Oscar Ces, Martin Buck
The phage shock protein (Psp) response maintains integrity of the inner membrane (IM) in response to extracytoplasmic stress conditions and is widely distributed amongst enterobacteria. Its central component PspA, a member of the IM30 peripheral membrane protein family, acts as a major effector of the system through its direct association with the IM. Under non-stress conditions PspA also negatively regulates its own expression via direct interaction with the AAA+ ATPase PspF. PspA has a counterpart in cyanobacteria called Vipp1, which is implicated in protection of the thylakoid membranes...
October 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27803183/a-two-component-regulatory-system-impacts-extracellular-membrane-derived-vesicle-production-in-group-a-streptococcus
#19
Ulrike Resch, James Anthony Tsatsaronis, Anaïs Le Rhun, Gerald Stübiger, Manfred Rohde, Sergo Kasvandik, Susanne Holzmeister, Philip Tinnefeld, Sun Nyunt Wai, Emmanuelle Charpentier
: Export of macromolecules via extracellular membrane-derived vesicles (MVs) plays an important role in the biology of Gram-negative bacteria. Gram-positive bacteria have also recently been reported to produce MVs; however, the composition and mechanisms governing vesiculogenesis in Gram-positive bacteria remain undefined. Here, we describe MV production in the Gram-positive human pathogen group A streptococcus (GAS), the etiological agent of necrotizing fasciitis and streptococcal toxic shock syndrome...
November 1, 2016: MBio
https://www.readbyqxmd.com/read/27788389/the-association-of-admission-blood-glucose-level-with-the-clinical-picture-and-prognosis-in-cardiogenic-shock-results-from-the-cardshock-study
#20
Anu Kataja, Tuukka Tarvasmäki, Johan Lassus, Jose Cardoso, Alexandre Mebazaa, Lars Køber, Alessandro Sionis, Jindrich Spinar, Valentina Carubelli, Marek Banaszewski, Rossella Marino, John Parissis, Markku S Nieminen, Veli-Pekka Harjola
BACKGROUND: Critically ill patients often present with hyperglycemia, regardless of previous history of diabetes mellitus (DM). Hyperglycemia has been associated with adverse outcome in acute myocardial infarction and acute heart failure. We investigated the association of admission blood glucose level with the clinical picture and short-term mortality in cardiogenic shock (CS). METHODS: Consecutively enrolled CS patients were divided into five categories according to plasma glucose level at the time of enrolment: hypoglycemia (glucose <4...
October 17, 2016: International Journal of Cardiology
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