keyword
https://read.qxmd.com/read/38540276/ectopic-expression-of-neurod1-is-sufficient-for-functional-recovery-following-a-sensory-motor-cortical-stroke
#1
JOURNAL ARTICLE
Jessica M Livingston, Tina T Lee, Tom Enbar, Emerson Daniele, Clara M Phillips, Alexandra Krassikova, K W Annie Bang, Ines Kortebi, Brennan W Donville, Omadyor S Ibragimov, Nadia Sachewsky, Daniela Lozano Casasbuenas, Arman Olfat, Cindi M Morshead
Stroke is the leading cause of adult disability worldwide. The majority of stroke survivors are left with devastating functional impairments for which few treatment options exist. Recently, a number of studies have used ectopic expression of transcription factors that direct neuronal cell fate with the intention of converting astrocytes to neurons in various models of brain injury and disease. While there have been reports that question whether astrocyte-to-neuron conversion occurs in vivo, here, we have asked if ectopic expression of the transcription factor Neurod1 is sufficient to promote improved functional outcomes when delivered in the subacute phase following endothelin-1-induced sensory-motor cortex stroke...
March 15, 2024: Biomedicines
https://read.qxmd.com/read/38539604/toe-grip-strength-is-associated-with-improving-gait-function-in-patients-with-subacute-stroke
#2
JOURNAL ARTICLE
Jin-Whan Ryu, In-Su Hwang, Sol Jin, Soo-A Kim, Min-Su Kim
Toe grip strength has recently been suggested to play an essential role in maintaining balance and postural stability for ambulatory function in older populations. This study aimed to investigate its association with improving gait function three months after onset in patients with subacute stroke. This longitudinal cohort study included 98 first-ever stroke patients (67 ± 9 years, 56% female) within one month from the onset who could not ambulate independently. Functional outcome indicators, including toe grip strength, hand grip strength, knee extensor strength, Fugl-Meyer Assessment of Lower Extremity (FMA_LE), and the Postural Assessment Scale for Stroke (PASS), were assessed before and three months after the intervention...
February 26, 2024: Brain Sciences
https://read.qxmd.com/read/38530801/clinical-gait-analysis-using-video-based-pose-estimation-multiple-perspectives-clinical-populations-and-measuring-change
#3
JOURNAL ARTICLE
Jan Stenum, Melody M Hsu, Alexander Y Pantelyat, Ryan T Roemmich
Gait dysfunction is common in many clinical populations and often has a profound and deleterious impact on independence and quality of life. Gait analysis is a foundational component of rehabilitation because it is critical to identify and understand the specific deficits that should be targeted prior to the initiation of treatment. Unfortunately, current state-of-the-art approaches to gait analysis (e.g., marker-based motion capture systems, instrumented gait mats) are largely inaccessible due to prohibitive costs of time, money, and effort required to perform the assessments...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38511170/early-exercise-intervention-promotes-myelin-repair-in-the-brains-of-ischemic-rats-by-inhibiting-the-mek-erk-pathway
#4
JOURNAL ARTICLE
Junyi Wang, Xinyu Ding, Chen Li, Chuan Huang, Changkai Ke, Chunlei Xu, Chunxiao Wan
Our previous studies have shown that early exercise intervention after stroke increases neural activity and synaptic plasticity and promotes the recovery of nerve fiber bundle integrity in the brain. However, the effect of exercise on the repair of myelin in the brain and the related mechanism are still unclear. In this study, we randomly divided the rats into three groups. Before and after 28 days of intervention, body weight, nerve function, the infarct size, white matter fiber bundle integrity, and nerve myelin structure and function were observed by measuring body weight, analysis of modified neurological severity score, CatWalk gait analysis, MRI, luxol fast blue staining, immunofluorescence, and transmission electron microscopy...
January 1, 2024: Translational Neuroscience
https://read.qxmd.com/read/38487103/compensatory-increase-in-ipsilesional-supplementary-motor-area-and-premotor-connectivity-is-associated-with-greater-gait-impairments-a-personalized-fmri-analysis-in-chronic-stroke
#5
JOURNAL ARTICLE
Xiaolong Peng, Shraddha Srivastava, Falon Sutton, Yongkuan Zhang, Bashar W Badran, Steven A Kautz
BACKGROUND: Balance and mobility impairments are prevalent post-stroke and a large number of survivors require walking assistance at 6 months post-stroke which diminishes their overall quality of life. Personalized interventions for gait and balance rehabilitation are crucial. Recent evidence indicates that stroke lesions in primary motor pathways, such as corticoreticular pathways (CRP) and corticospinal tract (CST), may lead to reliance on alternate motor pathways as compensation, but the current evidence lacks comprehensive knowledge about the underlying neural mechanisms...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38479182/tetramethylpyrazine-nitrone-alleviates-d-galactose-induced-murine-skeletal-muscle-aging-and-motor-deficits-by-activating-the-ampk-signaling-pathway
#6
JOURNAL ARTICLE
Lulin Nie, Kaiwu He, Chaoming Qiu, Qing Li, Bocheng Xiong, Chuanyue Gao, Xiufen Zhang, Mei Jing, Wei Wu, Jianjun Liu, Gaoxiao Zhang, Zaijun Zhang, Xifei Yang, Yewei Sun, Yuqiang Wang
Tetramethylpyrazine nitrone (TBN), a novel derivative of tetramethylpyrazine (TMP) designed and synthesized by our group, possesses multi-functional mechanisms of action and displays broad protective effects in vitro and in animal models of age-related brain disorders such as stroke, Alzheimer's disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Parkinson's disease (PD). In the present report, we investigated the effects of TBN on aging, specifically on muscle aging and the associated decline of motor functions...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38469745/improvement-of-gait-and-balance-function-in-chronic-post-stroke-patients-induced-by-lower-extremity-constraint-induced-movement-therapy-a-randomized-controlled-clinical-trial
#7
JOURNAL ARTICLE
Elaine Menezes-Oliveira, Gabriela da Silva Matuti, Clarissa Barros de Oliveira, Simone Ferreira de Freitas, Catia Miyuki Kawamura, José Augusto Fernandes Lopes, Jean Faber, Ricardo Mario Arida
OBJECTIVE: To evaluate the effects of Lower Extremity - Constraint Induced Movement Therapy on gait function and balance in chronic hemiparetic patients. METHODS: Randomized, controlled, single-blinded study. We recruited chronic post stroke patients and allocated them to Lower Extremity - Constraint Induced Movement Tharapy (LE-CIMT) or Control Group. The LE-CIMT group received this protocol 2.5 hour/day for 15 followed days, including: 1) intensive supervised training, 2) use of shaping as a strategy for motor training, and 3) application of a transfer package...
March 12, 2024: Brain Injury
https://read.qxmd.com/read/38468688/comparison-of-biomechanical-parameters-in-lower-limb-joints-of-stroke-patients-according-to-conventional-evaluation-scores-during-level-walking
#8
JOURNAL ARTICLE
HyeongMin Jeon, Eun-Hye Chung, Se-Young Bak, Heegoo Kim, Seyoung Shin, Hongseok Baek, MinYoung Kim
Objective: Patients with chronic stroke capable of independent gait were classified into functional ambulation category (FAC) 4 or 5, and the kinetic and kinematic data on their lower limb joints on the affected and unaffected sides were compared with that of healthy individuals. Finally, the qualitative changes in the gait of patients with stroke were investigated based on the differences in FAC scores. Methods: Twelve healthy participants and 19 patients with stroke capable of independent gait were included...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38449597/optimizing-3d-printed-ankle-foot-orthoses-for-patients-with-stroke-importance-of-effective-elastic-modulus-and-finite-element-simulation
#9
JOURNAL ARTICLE
Chien-Hsien Yeh, Keng-Ren Lin, Fong-Chin Su, Hsiu-Yun Hsu, Li-Chieh Kuo, Chih-Chun Lin
Patients with stroke often use ankle-foot orthoses (AFOs) for gait improvement. 3D printing technology has become a popular tool in recent years for the production of AFOs due to its strengths on customization and rapid manufacturing. However, the porosity of the 3D printed materials affects the kinetic features of these orthoses, leading to its lower-strength than solid ones. The effective elastic modulus of 3D printed material was measured following standard test method to obtain the kinetic features precisely in a finite element simulation...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38430995/modifying-the-mobility-scale-for-acute-stroke-msas-for-all-stroke-phases-msa-ll-s-measurement-properties-and-clinical-application
#10
JOURNAL ARTICLE
Shamala Thilarajah, Low Ai Ying, Amanda Lee, Sherie Ng, Seow Hui Chueng, Silvana Choo, Bok Chek Wai, Deidre De Silva, Eleanor Shuxian Chew, Chua Tse Lert, Li Khim Kwah, Pua Yong Hao
OBJECTIVE: To develop and examine the measurement properties and interpretability of the Mobility Scale for "All" Stroke Phases (MSAll S) as a potential single outcome measure to capture improvements in physical function throughout the stroke continuum. DESIGN: Retrospective cross-sectional study SETTING: Inpatient rehabilitation unit. PARTICIPANTS: People after stroke at discharge from rehabilitation (n=309). INTERVENTION: Not applicable...
February 29, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38419706/case-report-intrathecal-baclofen-therapy-improved-gait-pattern-in-a-stroke-patient-with-spastic-dystonia
#11
Kyung Min Kim, Tae Kwon Lee, Su Min Lee, Won Seok Chang, Su Ji Lee, Jihye Hwang, Sung-Rae Cho
BACKGROUND: Intrathecal baclofen (ITB) therapy, a viable alternative for unsuitable candidates of conventional spasticity medications, is a preferred method of administration over the oral route. Owing to its enhanced bioavailability, ITB ensures a more effective delivery at the target site. OBJECTIVE: There is a lack of conclusive evidence regarding the use of ITB treatment in managing ambulatory patients with spastic dystonia. Before ITB pump implantation, patients commonly undergo an ITB bolus injection trial to rule out potential adverse reactions and verify the therapeutic effects on hypertonic issues...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38419444/handwriting-movement-abnormalities-in-older-adults-with-silent-cerebral-small-vessel-disease-a-preliminary-study
#12
JOURNAL ARTICLE
Hongyi Zhao, Liyi Chi, Hans-Leo Teulings, Cuiqiao Xia, Yonghua Huang
BACKGROUND: The features of cerebral small vessel disease (CSVD) range from occurrence of asymptomatic radiological markers to symptomatic characteristics that include cognitive deficits and gait decline. The aim of the present study was to examine whether handwriting movement is abnormal in older people with CSVD through handwriting and drawing tasks using digitized handwriting kinematic assessment technology. METHODS: Older subjects ( n = 60) were grouped according to Fazekas score, with 16 in the Severe CSVD group, 12 in the Non-severe group and 32 in the Healthy group...
February 19, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38413134/aerobic-exercise-interventions-for-promoting-cardiovascular-health-and-mobility-after-stroke-a-systematic-review-with-bayesian-network-meta-analysis
#13
JOURNAL ARTICLE
Kevin Moncion, Lynden Rodrigues, Elise Wiley, Kenneth S Noguchi, Ahmed Negm, Julie Richardson, Maureen Jane MacDonald, Marc Roig, Ada Tang
OBJECTIVE: To determine the superiority of aerobic exercise (AE) interventions on key outcomes of stroke recovery, including cardiorespiratory fitness (V̇O2 peak, primary outcome), systolic blood pressure (SBP) and mobility (6 min Walk Test (6MWT) distance and 10 m Usual Gait Speed) after stroke. DATA SOURCES: MEDLINE, EMBASE, Web of Science, CINAHL, CENTRAL, SPORTDiscus, PsycINFO and AMED Allied and Complementary Medicine were searched from inception to February 2023...
February 27, 2024: British Journal of Sports Medicine
https://read.qxmd.com/read/38408745/quantitative-eeg-for-the-monitoring-of-walking-recovery-in-chronic-stroke-patients-receiving-action-observation-training
#14
JOURNAL ARTICLE
Fatemeh Shamsi, Hadi Aligholi, Mohammad Taghi Karimi, Afshin Borhani-Haghighi, Mohammad Nami
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO) or sham observation (SO) groups. Both groups received 12 sessions of intervention. Each session composed of 12 min of observational training, which depicted exercises for the experimental group but nature pictures for the sham group and 40 min of occupational therapy, which was the same for the both groups...
February 26, 2024: Journal of Motor Behavior
https://read.qxmd.com/read/38405374/relationship-between-hamstrings-quadriceps-strength-ratio-and-the-performance-of-tasks-in-berg-s-balance-scale-among-stroke-survivors-in-abakaliki-nigeria
#15
JOURNAL ARTICLE
Nonso Christian Asouzu, Emeka Mong, Maximin Agha, Nwabumma Cynthia Asouzu, Emelie Moris Anekwu, Davidson Okwudili John, Emmanuel Chiebuka Okoye, Sam Chidi Ibeneme
AIM: The study was designed to establish the relationship between hamstrings-quadriceps (H-Q) strength ratio and the performance of tasks in Berg's Balance Scale among stroke survivors. METHOD: Twenty-five stroke survivors participated in the study. The hamstrings and quadriceps muscle strengths of both the paretic and non-paretic sides were determined at 60° knee flexion with an electronic tensiometer. The participants undertook the tasks in Berg's Balance Scale...
2024: BMJ Open Sport & Exercise Medicine
https://read.qxmd.com/read/38391839/gait-analysis-of-hemiparetic-adult-patients-with-a-quadripod-cane-and-a-rolling-cane
#16
JOURNAL ARTICLE
Bérengère Maillard, Mohamed Boutaayamou, Helena Cassol, Laurence Pirnay, Jean-François Kaux
Stroke consequences include hemiparesis and difficulty walking. Several types of canes exist to overcome these alterations, but little data compares the quadripod cane and the rolling cane in hemiparetic patients. The objective of this work is twofold: to determine whether the gait speed-the most often used parameter to assess gait performance-depends on the type of cane, and to establish which spatiotemporal parameters have the most influence. Thirty-four hemiparetic patients performed 10 m walking tests at comfortable and fast speed conditions, using both canes on two different days...
February 12, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38391621/feasibility-of-an-application-based-outpatient-rehabilitation-program-for-stroke-survivors-acceptability-and-preliminary-results-for-patient-reported-outcomes
#17
JOURNAL ARTICLE
Annina Bindschedler, Carina Ziller, Eve-Yaël Gerber, Frank Behrendt, Björn Crüts, Katrin Parmar, Hans Ulrich Gerth, Szabina Gäumann, Wiebke Dierkes, Corina Schuster-Amft, Leo H Bonati
BACKGROUND: The majority of stroke survivors experience long-term impairments. Regular physical activity and other lifestyle modifications play an important role in rehabilitation. Outpatient rehabilitation using telemedicine might be suitable to improve functional ability and long-term secondary prevention. The Strokecoach Intervention Program (SIP, Strokecoach GmbH, Cologne, Germany) comprises training, coaching and monitoring with the aim of improving or at least maintaining functional independence and preventing further stroke through more targeted physical activity...
January 29, 2024: Bioengineering
https://read.qxmd.com/read/38390596/exergames-as-a-rehabilitation-tool-to-enhance-the-upper-limbs-functionality-and-performance-in-chronic-stroke-survivors-a-preliminary-study
#18
JOURNAL ARTICLE
Luca Vismara, Claudia Ferraris, Gianluca Amprimo, Giuseppe Pettiti, Francesca Buffone, Andrea Gianmaria Tarantino, Alessandro Mauro, Lorenzo Priano
INTRODUCTION: Post-stroke hemiplegia commonly occurs in stroke survivors, negatively impacting the quality of life. Despite the benefits of initial specific post-acute treatments at the hospitals, motor functions, and physical mobility need to be constantly stimulated to avoid regression and subsequent hospitalizations for further rehabilitation treatments. METHOD: This preliminary study proposes using gamified tasks in a virtual environment to stimulate and maintain upper limb mobility through a single RGB-D camera-based vision system (using Microsoft Azure Kinect DK)...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38390525/identifying-the-characteristics-of-patients-with-stroke-who-have-difficulty-benefiting-from-gait-training-with-the-hybrid-assistive-limb-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
Shingo Taki, Takeshi Imura, Tsubasa Mitsutake, Yuji Iwamoto, Ryo Tanaka, Naoki Imada, Hayato Araki, Osamu Araki
Robot-assisted gait training is effective for walking independence in stroke rehabilitation, the hybrid assistive limb (HAL) is an example. However, gait training with HAL may not be effective for everyone, and it is not clear who is not expected to benefit. Therefore, we aimed to identify the characteristics of stroke patients who have difficulty gaining benefits from gait training with HAL. We conducted a single-institutional retrospective cohort study. The participants were 82 stroke patients who had received gait training with HAL during hospitalization...
2024: Frontiers in Neurorobotics
https://read.qxmd.com/read/38375695/effects-of-robot-assisted-gait-training-on-motor-performance-of-lower-limb-in-poststroke-survivors-a-systematic-review-with-meta-analysis
#20
JOURNAL ARTICLE
S Liang, Z-Q Hong, Q Cai, H-G Gao, Y-J Ren, H-Q Zheng, X Chen, X-Q Hu
OBJECTIVE: This study aimed to investigate the effects of robot-assisted gait training (RAGT) on improving walking ability, and to determine the optimal dosage of task-specific training based on RAGT for stroke patients. MATERIALS AND METHODS: Two investigators independently searched electronic databases, including PubMed, Embase, Cochrane Library, and Physiotherapy Evidence Database (PEDro) from inception to 31 January 2020. The study design was a systematic review with meta-analysis of randomized controlled trials (RCTs), comparing the intervention of RAGT plus conventional therapy to conventional therapy alone...
February 2024: European Review for Medical and Pharmacological Sciences
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