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https://www.readbyqxmd.com/read/28228578/proof-of-concept-randomized-trial-of-the-monoclonal-antibody-gsk249320-versus-placebo-in-stroke-patients
#1
Steven C Cramer, Lori A Enney, Colleen K Russell, Monica Simeoni, Thomas R Thompson
BACKGROUND AND PURPOSE: One class of poststroke restorative therapy focuses on promoting axon outgrowth by blocking myelin-based inhibitory proteins such as myelin-associated glycoprotein. The purpose of the current study was to extend preclinical and clinical findings of GSK249320, a humanized monoclonal antibody to myelin-associated glycoprotein with disabled Fc region, to explore effects on motor outcomes post-stroke. METHODS: In this phase IIb double-blind, randomized, placebo-controlled study, patients at 30 centers with ischemic stroke 24 to 72 hours prior and gait deficits were randomized to 2 IV infusions of GSK249320 or placebo...
February 22, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28226805/detecting-voluntary-gait-intention-of-chronic-stroke-patients-towards-top-down-gait-rehabilitation-using-eeg
#2
Junhyuk Choi, Hyolim Kang, Sang Hun Chung, Yeonghun Kim, Ung Hee Lee, Jong Min Lee, Seung-Jong Kim, Min Ho Chun, Hyungmin Kim, Junhyuk Choi, Hyolim Kang, Sang Hun Chung, Yeonghun Kim, Ung Hee Lee, Jong Min Lee, Seung-Jong Kim, Min Ho Chun, Hyungmin Kim, Seung-Jong Kim, Yeonghun Kim, Jong Min Lee, Hyungmin Kim, Junhyuk Choi, Sang Hun Chung, Hyolim Kang, Min Ho Chun, Ung Hee Lee
One of the recent trends in gait rehabilitation is to incorporate bio-signals, such as electromyography (EMG) or electroencephalography (EEG), for facilitating neuroplasticity, i.e. top-down approach. In this study, we investigated decoding stroke patients' gait intention through a wireless EEG system. To overcome patient-specific EEG patterns due to impaired cerebral cortices, common spatial patterns (CSP) was employed. We demonstrated that CSP filter can be used to maximize the EEG signal variance-ratio of gait and standing conditions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220261/does-a-foot-drop-implant-improve-kinetic-and-kinematic-parameters-in-the-foot-and-ankle
#3
Kiriakos Daniilidis, Eike Jakubowitz, Anna Thomann, Sarah Ettinger, Christina Stukenborg-Colsman, Daiwei Yao
INTRODUCTION: Unlike the drop foot therapy with ortheses, the therapeutic effect of an implantable peroneus nerve stimulator (iPNS) is not well described. IPNS is a dynamic therapy option which is placed directly to the motoric part of the peroneal nerve and evokes a dorsiflexion of the paralysed foot. This retrospective study evaluates the kinematics and kinetics in drop foot patients who were treated with an iPNS. MATERIALS AND METHODS: 18 subjects (mean age 51...
February 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28218021/a-systematic-review-of-mechanisms-of-gait-speed-change-post-stroke-part-2-exercise-capacity-muscle-activation-kinetics-and-kinematics
#4
Elizabeth C Wonsetler, Mark G Bowden
BACKGROUND: Regaining locomotor ability is a primary goal in stroke rehabilitation and is most commonly measured using changes in self-selected walking speed. However, walking speed cannot identify the mechanisms by which an individual recovers. Laboratory-based mechanistic measures such as exercise capacity, muscle activation, force production, and movement analysis variables may better explain neurologic recovery. OBJECTIVES: The objectives of this systematic review are to examine changes in mechanistic gait outcomes and describe motor recovery as quantified by changes in laboratory-based mechanistic variables in rehabilitation trials...
February 20, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28196453/near-infrared-spectroscopy-in-gait-disorders
#5
Vera Gramigna, Giovanni Pellegrino, Antonio Cerasa, Simone Cutini, Roberta Vasta, Giuseppe Olivadese, Iolanda Martino, Aldo Quattrone
Walking is a complex motor behavior with a special relevance in clinical neurology. Many neurological diseases, such as Parkinson's disease and stroke, are characterized by gait disorders whose neurofunctional correlates are poorly investigated. Indeed, the analysis of real walking with the standard neuroimaging techniques poses strong challenges, and only a few studies on motor imagery or walking observation have been performed so far. Functional near-infrared spectroscopy (fNIRS) is becoming an important research tool to assess functional activity in neurological populations or for special tasks, such as walking, because it allows investigating brain hemodynamic activity in an ecological setting, without strong immobility constraints...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28187305/improvement-of-upper-trunk-posture-during-walking-in-hemiplegic-patients-after-injections-of-botulinum-toxin-into-the-arm
#6
Harald Hefter, Dietmar Rosenthal
BACKGROUND: It has been hypothesized that altered trunk movements during gait in post-stroke patients or children with cerebral palsy are compensatory to lower limb impairment. Improvement of trunk movements and posture after injections of botulinum toxin into the affected arm would be at variance with this hypothesis and hint towards a multifactorial trunk control deficit. PATIENTS AND METHODS: Clinical gait analysis was performed in 11 consecutively recruited hemiplegic patients immediately before and 4weeks after a botulinum toxin type A-injection into the affected arm...
January 26, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28166324/effect-of-intensive-blood-pressure-control-on-gait-speed-and-mobility-limitation-in-adults-75-years-or-older-a-randomized-clinical-trial
#7
Michelle C Odden, Carmen A Peralta, Dan R Berlowitz, Karen C Johnson, Jeffrey Whittle, Dalane W Kitzman, Srinivasan Beddhu, John W Nord, Vasilios Papademetriou, Jeff D Williamson, Nicholas M Pajewski
Importance: Intensive blood pressure (BP) control confers a benefit on cardiovascular morbidity and mortality; whether it affects physical function outcomes is unknown. Objective: To examine the effect of intensive BP control on changes in gait speed and mobility status. Design, Setting, and Participants: This randomized, clinical trial included 2636 individuals 75 years or older with hypertension and no history of type 2 diabetes or stroke who participated in the Systolic Blood Pressure Intervention Trial (SPRINT)...
February 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28113331/alignment-free-self-calibrating-elbow-angles-measurement-using-inertial-sensors
#8
Philipp Muller, Marc-Andre Begin, Thomas Schauer, Thomas Seel
Due to their relative ease of handling and low cost, inertial measurement unit (IMU)-based joint angle measurements are used for a widespread range of applications. These include sports performance, gait analysis and rehabilitation (e.g. Parkinson's disease monitoring or post-stroke assessment). However, a major downside of current algorithms, recomposing human kinematics from IMU data, is that they require calibration motions and/or the careful alignment of the IMUs with respect to the body segments. In this article, we propose a new method, which is alignment-free and self-calibrating using arbitrary movements of the user and an initial zero reference arm pose...
December 14, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#9
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28079633/criterion-referenced-values-of-grip-strength-and-usual-gait-speed-using-instrumental-activities-of-daily-living-disability-as-the-criterion
#10
Meng-Chih Lee, Chih-Cheng Hsu, Yi-Fen Tsai, Ching-Yu Chen, Cheng-Chieh Lin, Ching-Yi Wang
BACKGROUND AND PURPOSE: Current evidence suggests that grip strength and usual gait speed (UGS) are important predictors of instrumental activities of daily living (IADL) disability. Knowing the optimum cut points of these tests for discriminating people with and without IADL disability could help clinicians or researchers to better interpret the test results and make medical decisions. The purpose of this study was to determine the cutoff values of grip strength and UGS for best discriminating community-dwelling older adults with and without IADL disability, separately for men and women, and to investigate their association with IADL disability...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28074998/-prognostic-factors-of-functional-recovery-from-a-stroke-at-one-year
#11
J A Moreno-Palacios, I Moreno-Martinez, A Bartolome-Nogues, E Lopez-Blanco, R Juarez-Fernandez, I Garcia-Delgado
INTRODUCTION: Recovery of the ability to walk and independence is fundamental for any patient who suffers a stroke, and it can be influenced by a number of factors. AIM: To determine what variables are more important to achieve a good functional recovery at one year after the stroke. PATIENTS AND METHODS: An observational, longitudinal prospective study was conducted with 231 patients diagnosed with a stroke in the year 2013. An analysis was performed of the clinical characteristics, socio-demographic data, neurological situation at the time of hospitalisation -National Institute of Health Stroke Scale (NIHSS)-, functional situation (Rankin Scale and Barthel Index) and ability to walk, both on hospitalisation and on discharge from rehabilitation and at one year...
January 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28064358/incipient-progressive-supranuclear-palsy-is-more-common-than-expected-and-may-comprise-clinicopathological-subtypes-a-forensic-autopsy-series
#12
Koji Yoshida, Yukiko Hata, Koshi Kinoshita, Shutaro Takashima, Kortaro Tanaka, Naoki Nishida
We investigated 998 serial Japanese forensic autopsy cases (0-101 years old, mean age 61.7 ± 21.9), with no case selection, using immunohistochemistry to detect cases with progressive supranuclear palsy (PSP). Twenty-nine cases (mean age 82.3 ± 7.2 years, 11 males, 18 females) fulfilled the National Institute of Neuronal Disorders and Stroke (NINDS)-PSP pathological criteria (2.9% of all cases, 4.6% of cases over 60). All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP...
January 7, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28018979/increasing-access-to-cost-effective-home-based-rehabilitation-for-rural-veteran-stroke-survivors
#13
S N Housley, A R Garlow, K Ducote, A Howard, T Thomas, D Wu, K Richards, A J Butler
INTRODUCTION: An estimated 750,000 Americans experience a stroke annually. Most stroke survivors require rehabilitation. Limited access to rehabilitation facilities has a pronounced burden on functional outcomes and quality of life. Robotic devices deliver reproducible therapy without the need for real-time human oversight. This study examined the efficacy of using home-based, telerobotic-assisted devices (Hand and Foot Mentor: HM and FM) to improve functional ability and reduce depression symptoms, while improving access and cost savings associated with rehabilitation...
August 25, 2016: Austin Journal of Cerebrovascular Disease & Stroke
https://www.readbyqxmd.com/read/28007328/arterial-stiffness-in-subacute-stroke-changing-pattern-and-relationship-with-functional-recovery
#14
Eun Young Han, Bo Ryun Kim, Seung-Jae Joo, Chang Sub Lee, Sa-Yoon Kang, Song-Yi Kim, Joon Hyouk Choi, Chul Woong Hyun
BACKGROUND: To examine changing patterns in arterial stiffness and functional outcome in patients with subacute stroke, and to determine which parameter shows a strong correlation with the reversal of arterial stiffness, during a 3-month period of comprehensive rehabilitation therapy. METHODS: This descriptive, observational cohort study enrolled 60 patients (43 male and 17 female; average age, 62.7 years), and all received conventional rehabilitation therapy, during a 3-month period...
December 19, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27992350/alignment-free-self-calibrating-elbow-angles-measurement-using-inertial-sensors
#15
Philipp Muller, Marc-Andre Begin, Thomas Schauer, Thomas Seel
Due to their relative ease of handling and low cost, inertial measurement unit (IMU)-based joint angle measurements are used for a widespread range of applications. These include sports performance, gait analysis and rehabilitation (e.g. Parkinson's disease monitoring or post-stroke assessment). However, a major downside of current algorithms, recomposing human kinematics from IMU data, is that they require calibration motions and/or the careful alignment of the IMUs with respect to the body segments. In this article, we propose a new method, which is alignment-free and self-calibrating using arbitrary movements of the user and an initial zero reference arm pose...
December 14, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27990234/can-fes-augmented-active-cycling-training-improve-locomotion-in-post-acute-elderly-stroke-patients
#16
Elisabetta Peri, Emilia Ambrosini, Alessandra Pedrocchi, Giancarlo Ferrigno, Claudia Nava, Valentina Longoni, Marco Monticone, Simona Ferrante
Recent studies advocated the use of active cycling coupled with functional electrical stimulation to induce neuroplasticity and enhance functional improvements in stroke adult patients. The aim of this work was to evaluate whether the benefits induced by such a treatment are superior to standard physiotherapy. A single-blinded randomized controlled trial has been performed on post-acute elderly stroke patients. Patients underwent FES-augmented cycling training combined with voluntary pedaling or standard physiotherapy...
June 13, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/27979793/lower-magnetization-transfer-ratio-in-the-forceps-minor-is-associated-with-poorer-gait-velocity-in-older-adults
#17
S Seiler, L Pirpamer, B Gesierich, E Hofer, M Duering, D Pinter, E Jouvent, F Fazekas, J-F Mangin, H Chabriat, S Ropele, R Schmidt
BACKGROUND AND PURPOSE: Gait disturbances in the elderly are disabling and a major public health issue but are poorly understood. In this multimodal MR imaging study, we used 2 voxel-based analysis methods to assess the voxelwise relationship of magnetization transfer ratio and white matter hyperintensity location with gait velocity in older adults. MATERIALS AND METHODS: We assessed 230 community-dwelling participants of the Austrian Stroke Prevention Family Study...
December 15, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27942112/impact-of-the-difference-in-the-plantar-flexor-strength-of-the-ankle-joint-in-the-affected-side-among-hemiplegic-patients-on-the-plantar-pressure-and-walking-asymmetry
#18
Young Youl You, Sin Ho Chung, Hyung Jin Lee
[Purpose] This study was to examine the changes in the gait lines and plantar pressures in static and dynamic circumstances, according to the differences in the strengths of the plantar flexors in the ankle joints on the affected sides of hemiplegic patients, and to determine their impacts on walking symmetry. [Subjects and Methods] A total of thirty hospitalized stroke patients suffering from hemiplegia were selected in this study. The subjects had ankylosing patterns in the ankle joints of the affected sides...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27935557/wearable-tubing-assistive-walking-device-immediately-enhances-gait-parameters-in-subjects-with-stroke-a-randomized-controlled-study
#19
Seung-Mi Lee, Heon-Seock Cynn, Chung-Hwi Yi, Tae-Lim Yoon, Ji-Hyun Lee
BACKGROUND: Stroke patients develop compensatory movements due to limitations of ankle dorsiflexion and knee flexion. To solve the limitations, there are many adjustable walking assistive devices such as robotic devices, ankle-foot orthoses, and functional electric stimulation in rehabilitation session. However, these assistive devices have some disadvantages, including expense and discomforts. Therefore, the development of a new assistive device for stroke patients is needed to assist ankle dorsiflexion and knee flexion...
December 8, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27917945/improvement-in-stroke-induced-motor-dysfunction-by-music-supported-therapy-a-systematic-review-and-meta-analysis
#20
Yingshi Zhang, Jiayi Cai, Yaqiong Zhang, Tianshu Ren, Mingyi Zhao, Qingchun Zhao
To conduct a meta-analysis of clinical trials that examined the effect of music-supported therapy on stroke-induced motor dysfunction, comprehensive literature searches of PubMed, Embase and the Cochrane Library from their inception to April 2016 were performed. A total of 10 studies (13 analyses, 358 subjects) were included; all had acceptable quality according to PEDro scale score. The baseline differences between the two groups were confirmed to be comparable. Compared with the control group, the standardized mean difference of 9-Hole Peg Test was 0...
December 5, 2016: Scientific Reports
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