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https://www.readbyqxmd.com/read/28431452/-treatment-options-for-neurogenic-drop-foot-a-systematic-literature-research
#1
Eike Jakubowitz, Daiwei Yao, Henning Windhagen, Christina Stukenborg-Colsman, Anna Thomann, Kiriakos Daniilidis
Background Neurogenic drop foot may be caused by central or peripheral lesions of the nervous system. Depending on whether the first or second motor neuron is damaged, a flaccid or spastic drop foot develops. Spastic drop foot persists as a residual long-term complication after stroke in about 14 % of patients. Various conservative and surgical treatment options are available. Methods This article is based on a systematic literature review for medical evidence of functional electrical stimulation (FES) with the keywords "functional electrical stimulation AND drop foot" and "functional electrical stimulation AND gait AND stroke" in PubMed and Cochrane databases...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28431220/contribution-of-ankle-foot-orthosis-moment-in-regulating-ankle-and-knee-motions-during-gait-in-individuals-post-stroke
#2
Toshiki Kobayashi, Michael S Orendurff, Madeline L Singer, Fan Gao, K Bo Foreman
BACKGROUND: Ankle-foot orthosis moment resisting plantarflexion has systematic effects on ankle and knee joint motion in individuals post-stroke. However, it is not known how much ankle-foot orthosis moment is generated to regulate their motion. The aim of this study was to quantify the contribution of an articulated ankle-foot orthosis moment to regulate ankle and knee joint motion during gait in individuals post-stroke. METHODS: Gait data were collected from 10 individuals post-stroke using a Bertec split-belt instrumented treadmill and a Vicon 3-dimensional motion analysis system...
April 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28422551/estimation-of-gait-independence-using-a-tri-axial-accelerometer-in-stroke-patients
#3
Yoshifumi Kijima, Ryoji Kiyama, Masaki Sekine, Toshiyo Tamura, Toshiro Fujimoto, Tetsuo Maeda, Tadasu Ohshige
The purpose of this study was to clarify whether a gait analysis using an accelerometer could estimate gait independence. Eighty-six stroke patients and 21 healthy control subjects participated in this study. Stroke patients were identified as dependent or independent based on their gait ability. The acceleration of the trunk and bilateral thigh was measured using three wireless sensors during walking. The root mean square, gait regularity, and symmetry were calculated from the acceleration to estimate gait quality...
April 19, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28407505/a-randomized-controlled-trial-on-providing-ankle-foot-orthoses-in-patients-with-sub-acute-stroke-short-term-kinematic-and-spatiotemporal-effects-and-effects-of-timing
#4
Corien D M Nikamp, Marte S H Hobbelink, Job van der Palen, Hermie J Hermens, Johan S Rietman, Jaap H Buurke
Initial walking function is often limited after stroke, and regaining walking ability is an important goal in rehabilitation. Various compensatory movement strategies to ensure sufficient foot-clearance are reported. Ankle-foot orthoses (AFOs) are often prescribed to improve foot-clearance and may influence these strategies. However, research studying effects of actual AFO-provision early after stroke is limited. We conducted an explorative randomized controlled trial and aimed to study the short-term effects of AFO-provision on kinematic and spatiotemporal parameters in patients early after stroke...
March 30, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28395933/electroacupuncture-improves-neurobehavioral-function-and-brain-injury-in-rat-model-of-intracerebral-hemorrhage
#5
Yan Zhu, Li Deng, Huajun Tang, Xiaoqing Gao, Youhua Wang, Kan Guo, Jiming Kong, Chaoxian Yang
Acupuncture has been widely used as a treatment for stroke in China for a long time. Recently, studies have demonstrated that electroacupuncture (EA) can accelerate intracerebral hemorrhage (ICH)-induced angiogenesis in rats. In the present study, we investigated the effect of EA on neurobehavioral function and brain injury in ICH rats. ICH was induced by stereotactic injection of collagenase type I and heparin into the right caudate putamen. Adult ICH rats were randomly divided into the following three groups: model control group (MC), EA at non-acupoint points group (non-acupoint EA) and EA at Baihui and Dazhui acupoints group (EA)...
April 7, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28363987/progesterone-induced-neuroprotection-in-reperfusion-promoted-mitochondrial-dysfunction-following-focal-cerebral-ischemia-in-rats
#6
Syed Suhail Andrabi, Suhel Parvez, Heena Tabassum
Alterations in mitochondrial permeability transition and organelle damage are key players in the development of cerebral ischemic tissue injury due to associated modifications in ATP turnover and cellular apoptosis/necrosis. Early restoration of blood flow and improvement of mitochondrial function might reverse the situation and help in recovery following an onset of stroke. Mitochondria and related bioenergetics can be effectively used as pharmacological targets. Progesterone (P4), one of the promising neurosteroids, has been found neuroprotective in various models of neurological diseases through a number of mechanisms...
March 31, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28351743/effects-of-treadmill-training-with-load-addition-on-non-paretic-lower-limb-on-gait-parameters-after-stroke-a-randomized-controlled-clinical-trial
#7
Tatiana S Ribeiro, Emília M G S Silva, Isaíra A P Silva, Mayara F P Costa, Fabrícia A C Cavalcanti, Ana R Lindquist
The addition of load on the non-paretic lower limb for the purpose of restraining this limb and stimulating the use of the paretic limb has been suggested to improve hemiparetic gait. However, the results are conflicting and only short-term effects have been observed. This study aims to investigate the effects of adding load on non-paretic lower limb during treadmill gait training as a multisession intervention on kinematic gait parameters after stroke. With this aim, 38 subacute stroke patients (mean time since stroke: 4...
March 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28349208/periventricular-white-matter-lesions-as-a-prognostic-factor-of-swallowing-function-in-older-patients-with-mild-stroke
#8
Hyun Im Moon, Je-Shik Nam, Min Jeong Leem, Kee Hoon Kim
Older patients with stroke have poor functional prognosis compared to younger patients. Patients with stroke who have severe white matter (WM) lesions have been reported to have poor functional prognosis such as cognitive dysfunction, increased propensity for falling, and gait and balance problems. The aim of this study was to determine whether WM lesions exert negative effects on swallowing function in older patients with mild stroke. We conducted a retrospective analysis of 63 patients aged >65 years who had a National Institutes of Health Stroke Scale score ≤5 and who underwent videofluoroscopic swallowing examination after their first stroke...
March 27, 2017: Dysphagia
https://www.readbyqxmd.com/read/28291737/advantages-of-eeg-phase-patterns-for-the-detection-of-gait-intention-in-healthy-and-stroke-subjects
#9
Andreea Ioana Sburlea, Luis Montesano, Javier Minguez
OBJECTIVE: One use of EEG-based brain-computer interfaces (BCIs) in rehabilitation is the detection of movement intention. In this paper we investigate for the first time the instantaneous phase of movement related cortical potential (MRCP) and its application to the detection of gait intention. APPROACH: We demonstrate the utility of MRCP phase in two independent datasets, in which 10 healthy subjects and 9 chronic stroke patients executed a self-initiated gait task in three sessions...
March 14, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28284572/an-articulated-ankle-foot-orthosis-with-adjustable-plantarflexion-resistance-dorsiflexion-resistance-and-alignment-a-pilot-study-on-mechanical-properties-and-effects-on-stroke-hemiparetic-gait
#10
Toshiki Kobayashi, Michael S Orendurff, Grace Hunt, Lucas S Lincoln, Fan Gao, Nicholas LeCursi, K Bo Foreman
Mechanical properties of an articulated ankle-foot orthosis (AFO) are closely related to gait performance in individuals post-stroke. This paper presents a pilot study on the mechanical properties of a novel articulated AFO with adjustable plantarflexion resistance, dorsiflexion resistance and alignment, and its effect on ankle and knee joint kinematics and kinetics in an individual post-stroke during gait. The mechanical properties of the AFO were quantified. Gait analysis was performed using a 3D motion capture system with a split-belt instrumented treadmill under 12 different settings of the mechanical properties of the AFO [i...
March 8, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28271220/constraints-on-perception-of-information-from-obstacles-during-foot-clearance-in-people-with-chronic-stroke
#11
Mohsen Shafizadeh, Jonathan Wheat, Keith Davids, Noureddin Nakhostin Ansari, Ali Ali, Samira Garmabi
The aim of this study was to examine effects of different types of task constraints on coupling of perception and action in people with chronic stroke when crossing obstacles during a walking task. Ten participants with hemiplegic chronic stroke volunteered to walk over a static obstacle under two distinct task constraints: simple and dual tasks. Under simple task constraints, without specific instructions, participants walked at their preferred speed and crossed over an obstacle. Under dual task constraints, the same individuals were required to subtract numbers whilst walking...
March 7, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28271039/deep-multi-scale-location-aware-3d-convolutional-neural-networks-for-automated-detection-of-lacunes-of-presumed-vascular-origin
#12
Mohsen Ghafoorian, Nico Karssemeijer, Tom Heskes, Mayra Bergkamp, Joost Wissink, Jiri Obels, Karlijn Keizer, Frank-Erik de Leeuw, Bram van Ginneken, Elena Marchiori, Bram Platel
Lacunes of presumed vascular origin (lacunes) are associated with an increased risk of stroke, gait impairment, and dementia and are a primary imaging feature of the small vessel disease. Quantification of lacunes may be of great importance to elucidate the mechanisms behind neuro-degenerative disorders and is recommended as part of study standards for small vessel disease research. However, due to the different appearance of lacunes in various brain regions and the existence of other similar-looking structures, such as perivascular spaces, manual annotation is a difficult, elaborative and subjective task, which can potentially be greatly improved by reliable and consistent computer-aided detection (CAD) routines...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28268625/detecting-voluntary-gait-intention-of-chronic-stroke-patients-towards-top-down-gait-rehabilitation-using-eeg
#13
Junhyuk Choi, Hyolim Kang, Sang Hun Chung, Yeonghun Kim, Ung Hee Lee, Jong Min Lee, Seung-Jong Kim, Min Ho Chun, Hyungmin Kim
One of the recent trends in gait rehabilitation is to incorporate bio-signals, such as electromyography (EMG) or electroencephalography (EEG), for facilitating neuroplasticity, i.e. top-down approach. In this study, we investigated decoding stroke patients' gait intention through a wireless EEG system. To overcome patient-specific EEG patterns due to impaired cerebral cortices, common spatial patterns (CSP) was employed. We demonstrated that CSP filter can be used to maximize the EEG signal variance-ratio of gait and standing conditions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267989/responses-to-gait-perturbations-in-stroke-survivors-who-prospectively-experienced-falls-or-no-falls
#14
Michiel Punt, Sjoerd M Bruijn, Sanne Roeles, Ingrid G van de Port, Harriet Wittink, Jaap H van Dieën
BACKGROUND: Steady-state gait characteristics appear promising as predictors of falls in stroke survivors. However, assessing how stroke survivors respond to actual gait perturbations may result in better fall predictions. We hypothesize that stroke survivors who fall have a diminished ability to adequately adjust gait characteristics after gait is perturbed. This study explored whether gait characteristics of perturbed gait differ between fallers and non fallers. METHOD: Chronic stroke survivors were recruited by clinical therapy practices...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28254515/hereditary-cerebral-small-vessel-disease-and-stroke
#15
REVIEW
Christian Baastrup Søndergaard, Jørgen Erik Nielsen, Christine Krarup Hansen, Hanne Christensen
Cerebral small vessel disease is considered hereditary in about 5% of patients and is characterized by lacunar infarcts and white matter hyperintensities on MRI. Several monogenic hereditary diseases causing cerebral small vessel disease and stroke have been identified. The purpose of this systematic review is to provide a guide for determining when to consider molecular genetic testing in patients presenting with small vessel disease and stroke. CADASIL, CARASIL, collagen type IV mutations (including PADMAL), retinal vasculopathy with cerebral leukodystrophy, Fabry disease, hereditary cerebral hemorrhage with amyloidosis, and forkhead box C1 mutations are described in terms of genetics, pathology, clinical manifestation, imaging, and diagnosis...
April 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28243195/part-2-adaptation-of-gait-kinematics-in-unilateral-cerebral-palsy-demonstrates-preserved-independent-neural-control-of-each-limb
#16
Thomas C Bulea, Christopher J Stanley, Diane L Damiano
Motor adaptation, or alteration of neural control in response to a perturbation, is a potential mechanism to facilitate motor learning for rehabilitation. Central nervous system deficits are known to affect locomotor adaptation; yet we demonstrated that similar to adults following stroke, children with unilateral brain injuries can adapt step length in response to unilateral leg weighting. Here, we extend our analysis to explore kinematic strategies underlying step length adaptation and utilize dynamical systems approaches to elucidate how neural control may differ in those with hemiplegic CP across legs and compared to typically developing controls...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28228578/proof-of-concept-randomized-trial-of-the-monoclonal-antibody-gsk249320-versus-placebo-in-stroke-patients
#17
Steven C Cramer, Lori A Enney, Colleen K Russell, Monica Simeoni, Thomas R Thompson
BACKGROUND AND PURPOSE: One class of poststroke restorative therapy focuses on promoting axon outgrowth by blocking myelin-based inhibitory proteins such as myelin-associated glycoprotein. The purpose of the current study was to extend preclinical and clinical findings of GSK249320, a humanized monoclonal antibody to myelin-associated glycoprotein with disabled Fc region, to explore effects on motor outcomes poststroke. METHODS: In this phase IIb double-blind, randomized, placebo-controlled study, patients at 30 centers with ischemic stroke 24 to 72 hours prior and gait deficits were randomized to 2 IV infusions of GSK249320 or placebo...
March 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28226805/detecting-voluntary-gait-intention-of-chronic-stroke-patients-towards-top-down-gait-rehabilitation-using-eeg
#18
Junhyuk Choi, Hyolim Kang, Sang Hun Chung, Yeonghun Kim, Ung Hee Lee, Jong Min Lee, Seung-Jong Kim, Min Ho Chun, Hyungmin Kim, Junhyuk Choi, Hyolim Kang, Sang Hun Chung, Yeonghun Kim, Ung Hee Lee, Jong Min Lee, Seung-Jong Kim, Min Ho Chun, Hyungmin Kim, Seung-Jong Kim, Yeonghun Kim, Jong Min Lee, Hyungmin Kim, Junhyuk Choi, Sang Hun Chung, Hyolim Kang, Min Ho Chun, Ung Hee Lee
One of the recent trends in gait rehabilitation is to incorporate bio-signals, such as electromyography (EMG) or electroencephalography (EEG), for facilitating neuroplasticity, i.e. top-down approach. In this study, we investigated decoding stroke patients' gait intention through a wireless EEG system. To overcome patient-specific EEG patterns due to impaired cerebral cortices, common spatial patterns (CSP) was employed. We demonstrated that CSP filter can be used to maximize the EEG signal variance-ratio of gait and standing conditions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220261/does-a-foot-drop-implant-improve-kinetic-and-kinematic-parameters-in-the-foot-and-ankle
#19
Kiriakos Daniilidis, Eike Jakubowitz, Anna Thomann, Sarah Ettinger, Christina Stukenborg-Colsman, Daiwei Yao
INTRODUCTION: Unlike the drop foot therapy with ortheses, the therapeutic effect of an implantable peroneus nerve stimulator (iPNS) is not well described. IPNS is a dynamic therapy option which is placed directly to the motoric part of the peroneal nerve and evokes a dorsiflexion of the paralysed foot. This retrospective study evaluates the kinematics and kinetics in drop foot patients who were treated with an iPNS. MATERIALS AND METHODS: 18 subjects (mean age 51...
April 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28218021/a-systematic-review-of-mechanisms-of-gait-speed-change-post-stroke-part-2-exercise-capacity-muscle-activation-kinetics-and-kinematics
#20
Elizabeth C Wonsetler, Mark G Bowden
BACKGROUND: Regaining locomotor ability is a primary goal in stroke rehabilitation and is most commonly measured using changes in self-selected walking speed. However, walking speed cannot identify the mechanisms by which an individual recovers. Laboratory-based mechanistic measures such as exercise capacity, muscle activation, force production, and movement analysis variables may better explain neurologic recovery. OBJECTIVES: The objectives of this systematic review are to examine changes in mechanistic gait outcomes and describe motor recovery as quantified by changes in laboratory-based mechanistic variables in rehabilitation trials...
February 20, 2017: Topics in Stroke Rehabilitation
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