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Takayasu's arteritis

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https://www.readbyqxmd.com/read/29761968/-computer-assisted-quantitative-analysis-of-contrast-enhanced-ultrasonography-in-takayasu-arteritis-carotid-artery-lesions
#1
Yanlu Hu, Qi Zhang, Chaolun Li
Takayasu arteritis (TA) is a chronic nonspecific inflammation that commonly occurs in the aorta and its main branches. Most patients with TA are lack of clinical manifestations, leading to misdiagnosis. When the TA is correctly diagnosed, the patients may already have stenosis or occlusion in the involved arteries, resulting in arterial ischemia and hypoxia symptoms, and in severe cases it will be life-threatening. Contrast-enhanced ultrasonography (CEUS) is an emerging method for assessing TA, but the assessment relies heavily on experiences of radiologists performing manual and qualitative analyses, so the diagnostic results are often not accurate...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29742991/takayasu-arteritis-presenting-as-unexplained-pulmonary-consolidation-a-case-report
#2
Hirofumi Koike, Kazuto Ashizawa, Hideyuki Hayashi, Ichiro Sakamoto, Shigeki Nakamura, Ayako Nishino, Tomayoshi Hayashi, Masataka Uetani
Although Takayasu arteritis (TA) is rare as a form of chronic inflammatory arteritis, it is important that it is diagnosed early because the 10-year survival rate is only 84% to 87%. Many reported patients have been young women in East Asia. We report a case of a young woman who originally presented with unexplained pulmonary consolidation. Five years later, contrast-enhanced computed tomography (CT) imaging showed thickening of the walls of the aorta and its branches and of the main and right pulmonary artery (PA), and occlusion of the left subclavian and left PAs...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29735781/multiple-extracranial-carotid-aneurysms-in-a-patient-of-takayasu-arteritis
#3
Sanjay Tyagi, Mohit Dayal Gupta, Girish M P, Prattay Guha Sarkar
No abstract text is available yet for this article.
May 7, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29729868/treatment-of-takayasu-arteritis-with-the-il-6r-antibody-tocilizumab-vs-cyclophosphamide
#4
Xiufang Kong, Xiaojie Zhang, Peng Lv, Xiaomeng Cui, Lili Ma, Huiyong Chen, Hao Liu, Jiang Lin, Lindi Jiang
OBJECTIVE: To evaluate the treatment effects of the IL-6R antibody tocilizumab and cyclophosphamide (CTX) in patients with Takayasu arteritis (TA) and explore the mechanism by analyzing their effects on various cytokines. METHODS AND MATERIALS: This study included 9 TA patients treated with tocilizumab, 15 TA patients treated with CTX and 24 healthy controls. Treatment effects were evaluated based on: (1) Kerr score and Indian Takayasu Clinical Activity Score (ITAS2010), (2) improvement of previous lesions and occurrence of new vascular lesions on magnetic resonance angiography (MRA), (3) changes in various cytokine levels, (4) glucocorticoid sparing, and (5) adverse effects...
May 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29729450/new-use-for-an-old-treatment-hydroxychloroquine-as-a-potential-treatment-for-systemic-vasculitis
#5
REVIEW
Alina Casian, Shirish Sangle, David P D'Cruz
Antimalarials have been an effective and safe treatment for autoimmune rheumatic diseases such as systemic lupus erythematosus for more than a hundred years. There are surprisingly few reports of hydroxychloroquine use in the systemic vasculitides. Hydroxychloroquine has antithrombotic, cardiovascular, antimicrobial and antineoplastic effects, making it a potentially valuable treatment for patients with systemic vasculitis who are at risk of infections, malignancy and thrombotic events. We report the successful use of hydroxychloroquine in patients with ANCA vasculitis, Henoch Schonlein purpura/IgA vasculitis, Takayasu's arteritis and polyarteritis nodosa...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729444/non-glucocorticoid-drugs-for-the-treatment-of-takayasu-s-arteritis-a-systematic-review-and-meta-analysis
#6
REVIEW
Lillian Barra, Grace Yang, Christian Pagnoux
BACKGROUND: Takayasu's Arteritis (TAK) affects mostly young women and causes significant morbidity. Most patients are refractory to glucocorticoids (GC) or relapse when GC doses are reduced. The objective of this study is to summarize the literature pertaining to the effectiveness of non-GC drugs for the treatment of TAK. METHODS: MEDLINE and Embase were searched for English-language studies of TAK patients with a sample size >5. Studies were included if the effectiveness of non-GC drugs for the treatment of TAK was reported...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29690806/a-case-of-ankylosing-spondylitis-with-concurrent-takayasu-arteritis
#7
Masakazu Matsushita, Shigeto Kobayashi, Kurisu Tada, Eri Hayashi, Ken Yamaji, Atsushi Amano, Naoto Tamura
We herein report a case involving a 56-year-old man who had experienced neck and lower back pain since the age of 23 years. Ankylosing spondylitis (AS) was diagnosed at 41 years of age, and treatment with sulfasalazine was initiated. At 44 years of age, the patient developed respiratory distress on exertion and chest pain. Aortic regurgitation (AR) was diagnosed via echocardiography, and the patient presented to our hospital for close examination and treatment. Coronary computed tomography angiography revealed no lesions in the coronary artery; however, magnetic resonance angiography revealed stenotic lesions in the left common carotid artery and left subclavian artery...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29687289/analysis-of-predictive-factors-for-treatment-resistance-and-disease-relapse-in-takayasu-s-arteritis
#8
Ying Sun, Lili Ma, Huiyong Chen, Xiufang Kong, Peng Lv, Xiaomin Dai, Zongfei Ji, Chengde Yang, Shengming Dai, Lijun Wu, Yaohong Zou, Jiang Lin, Hongcheng Shi, Qiang Yu, Lindi Jiang
The objective of the study was to investigate the long-term treatment effects and predictive factors for treatment response and disease relapse for Takayasu's arteritis (TA). Eighty-one patients were recruited from the Department of Rheumatology, Zhongshan Hospital, Fudan University, between January 2009 and January 2015. The follow-up duration ranged from 6 to 36 months. Patients were divided into three groups: clinical remission (CR; n = 59); treatment-resistant (TR; n = 11); and disease relapse (DR; n = 11)...
April 23, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#9
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29678346/efficacy-of-tocilizumab-in-takayasu-arteritis-multicenter-retrospective-study-of-46-patients
#10
Arsene Mekinian, Mathieu Resche-Rigon, Cloé Comarmond, Alessandra Soriano, Joel Constans, Laurent Alric, Patrick Jego, Florian Busato, Matthieu Cabon, Robin Dhote, Lazaro Estibaliz, Isabelle Kone Pault, Cédric Landron, Christian Lavigne, Bertrand Lioger, Martin Michaud, Marc Ruivard, Karim Sacre, Jacques Eric Gottenberg, Francis Gaches, Tiphaine Goulenok, Carlo Salvarani, Patrice Cacoub, Olivier Fain, David Saadoun
OBJECTIVES: To assess the efficacy of tocilizumab in patients with Takayasu arteritis (TA). METHODS: We conducted a retrospective multicenter study in 46 TA patients treated with tocilizumab. We analyzed factors associated with response to tocilizumab (assessed using NIH score). RESULTS: Forty-six patients with TA were included, with a median age of 43 years [29-54], and 35 (76%) females. We observed a decrease in the median NIH scale (from 3 [2-3] at baseline to 0 [0-1] and 0 at 3 and 6 months, respectively; p < 0...
April 17, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29674517/tricky-case-of-takayasu-arteritis-in-a-young-child-presenting-with-heart-failure-and-femoral-pulses
#11
Marianna Fabi, Maurizio Brighenti, Andrea Donti, Marcello Lanari
No abstract text is available yet for this article.
April 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29666047/comparison-of-magnetic-resonance-angiography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-large-vessel-vasculitis
#12
Kaitlin A Quinn, Mark A Ahlman, Ashkan A Malayeri, Jamie Marko, Ali Cahid Civelek, Joel S Rosenblum, Armin A Bagheri, Peter A Merkel, Elaine Novakovich, Peter C Grayson
OBJECTIVES: To assess agreement between interpretation of magnetic resonance angiography (MRA) and 18 F-fluorodeoxyglucose positron emission tomography (PET) for disease extent and disease activity in large-vessel vasculitis (LVV) and determine associations between imaging and clinical assessments. METHODS: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK) and comparators were recruited into a prospective, observational cohort. Imaging and clinical assessments were performed concurrently, blinded to each other...
April 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29665349/isolated-arteritis-of-both-lower-limbs
#13
Miroslav Průcha, Alena Šnajdrová, Pavel Zdráhal
Isolated arteritis of the lower limb vessels is an extremely rare condition. The use of modern vascular imaging techniques substantially facilitates and accelerates the diagnostics. In the isolated lower limb arteritis, it is always necessary to exclude Takayasu's and giant-cell arteritis. We present the case of a female patient with an isolated lower extremity arteritis without any other symptoms of systemic vascular damage or systemic autoimmune disease. Immunosuppressive therapy is obligatory in this case...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29657869/impaired-cardiac-and-vascular-motion-in-patients-with-takayasu-s-arteritis-a-velocity-vector-imaging-based-study
#14
Selen Yurdakul, Fatma Alibaz-Öner, Haner Direskeneli, Saide Aytekin
Objective: Takayasu's arteritis (TAK) is a chronic inflammatory vasculitis of the aorta and its major branches. In the present study, we aimed to evaluate the motion of the vascular wall and myocardial contractility by using a novel strain imaging method, velocity vector imaging (VVI), in patients with TAK. We also aimed to compare them with another inflammatory autoimmune disorder, systemic lupus erythematosus (SLE). Methods: We studied 33 patients with TAK, 18 patients with SLE, and 20 age- and sex-matched controls...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29651889/how-to-conduct-research-of-rare-autoimmune-diseases
#15
Chikashi Terao
Rare autoimmune diseases are difficult to conduct researches in spite of present era with advanced scientific progress. Research using genetic approach is a promising way since genetic findings implicate causality of diseases. Still, there are multiple obstacles preventing genetic studies of rare diseases. Here, we list up the problems and propose solutions for them with detailed examples. The biggest problem is that it is difficult to collect a substantial number of DNA samples from patients with rare diseases...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29643949/high-secretion-of-interleukin-6-and-increased-mincle-receptor-expression-upon-exposure-to-mycobacterial-cord-factor-analog-trehalose-6-6-dibehenate-tdb-in-patients-with-takayasu-arteritis
#16
Nikhil Gupta, Jayakanthan Kabeerdoss, Hindhumathi Mohan, Ruchika Goel, Debashish Danda
Introduction: Suspicion on the association between Takayasu Arteritis (TA) and Tubcerculosis (TB) has been in vogue for years. Prevalence of TB in TA is reported to be higher. We aimed to study innate immune responses in patients with TA on exposure to Trehalose-6,6-dibehenate (TDB), a synthetic analogue of Trehalose-6,6-Dimycolate (TDM, also known as mycobacterial cord factor) in comparison with healthy controls. Materials and Methods: Patients with type V TA, satisfying 1990 ACR criteria, and age and sex matched healthy controls were recruited...
2018: Open Rheumatology Journal
https://www.readbyqxmd.com/read/29624875/radiology-and-biomarkers-in-assessing-disease-activity-in-takayasu-arteritis
#17
Ying Sun, Qingrong Huang, Lindi Jiang
No abstract text is available yet for this article.
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29624864/takayasu-arteritis-and-giant-cell-arteritis-are-they-a-spectrum-of-the-same-disease
#18
Tanaz A Kermani
No abstract text is available yet for this article.
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29622513/endovascular-versus-open-surgical-intervention-in-patients-with-takayasu-s-arteritis-a-meta-analysis
#19
REVIEW
Jae Hyun Jung, Young Ho Lee, Gwan Gyu Song, Han Saem Jeong, Jae-Hoon Kim, Sung Jae Choi
OBJECTIVE/BACKGROUND: Although medical treatment has advanced, surgical treatment is needed to control symptoms of Takayasu's arteritis (TA), such as angina, stroke, hypertension, or claudication. Endovascular or open surgical intervention is performed; however, there are few comparative studies on these methods. This meta-analysis and systematic review aimed to examine the outcome of surgical treatment of TA. METHODS: A meta-analysis comparing outcomes of endovascular and open surgical intervention was performed using MEDLINE and Embase...
April 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29600943/silent-arterial-inflammation-during-the-apparent-remission-state-of-takayasu-s-arteritis-what-do-cytokines-tell-us
#20
Bruna Savioli, Bruno Ramos Salu, Marlon Vilela de Brito, Maria Luiza Vilela Oliva, Alexandre W S de Souza
OBJECTIVES: To evaluate serum cytokines as biomarkers of smoldering disease activity in patients with Takayasu's arteritis (TAK) in remission. METHODS: Thirty-four TAK patients with stable disease during the last 6 months and 22 healthy controls (HC) were included in a cross-sectional study. Serum levels of pro-inflammatory, anti-inflammatory, Th1, Th2, Th9, Th17 and Th22 cytokines were measured by the multiplex technique. RESULTS: No significant differences regarding serum cytokine levels were found between TAK patients and HC...
March 19, 2018: Clinical and Experimental Rheumatology
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