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Takayasu's arteritis

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https://www.readbyqxmd.com/read/29146018/biological-treatments-in-giant-cell-arteritis-takayasu-arteritis
#1
Maxime Samson, Georgina Espígol-Frigolé, Nekane Terrades-García, Sergio Prieto-González, Marc Corbera-Bellalta, Roser Alba-Rovira, José Hernández-Rodríguez, Sylvain Audia, Bernard Bonnotte, Maria C Cid
Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are the two main large vessel vasculitides. They share some similarities regarding their clinical, radiological and histological presentations but some pathogenic processes in GCA and TAK are activated differently, thus explaining their different sensitivity to biological therapies. The treatment of GCA and TAK essentially relies on glucocorticoids. However, thanks to major progress in our understanding of their pathogenesis, the role of biological therapies in the treatment of these two vasculitides is expanding, especially in relapsing or refractory diseases...
November 13, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29145713/positron-emission-tomography-as-an-imaging-biomarker-in-a-prospective-longitudinal-cohort-of-patients-with-large-vessel-vasculitis
#2
Peter C Grayson, Sara Alehashemi, Armin A Bagheri, Ali Cahid Civelek, Thomas R Cupps, Mariana J Kaplan, Ashkan A Malayeri, Peter A Merkel, Elaine Novakovich, David A Bluemke, Mark A Ahlman
OBJECTIVES: To assess the clinical value of (18) F-flurodeoxyglucose (FDG) positron emission tomography (PET) in a prospective cohort of patients with large-vessel vasculitis (LVV) and disease comparators. METHODS: Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at six-month intervals...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29137089/a-case-report-of-takayasu-arteritis-with-aortic-dissection-as-initial-presentation
#3
JiGuang Guo, GuoWu Zhang, Dan Tang, JianBin Zhang
RATIONALE: The initial symptoms and signs of Takayasu arteritis vary due to the heterogeneity of affected vessels. Moreover, the vascular lesions are difficult to detect at initial presentation, making diagnosis even more challenging. Although cases of aortic dissection with arteritis history have been reported, Takayasu arteritis in men with aortic dissection as initial presentation is very rare. PATIENT CONCERNS: A 37-year-old man presenting with persistent chest and back pain for 6 days was transferred to our hospital for further treatment...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29130681/nodular-glomerulosclerosis-not-always-diabetic-nephropathy
#4
Olga Balafa, Georgios Liapis
Nodular glomerulosclerosis -as it was originally described by Kimmelstiel and Wilson- is the main pathognomonic lesion of diabetic nephropathy. However, this particular pattern can also be seen in other conditions such as membranoproliferative glomerulonephritis, light or heavy chain deposition disease, amyloidosis, fibrillary and immunotactoid glomerulonephritis and Takayasu's arteritis. History of diabetes as well as other clinical and pathological features are of crucial importance in order to determine the precise cause of nodular glomerulosclerosis...
November 10, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29119033/the-utility-of-mri-in-the-diagnosis-of-takayasu-arteritis
#5
Marian Gaballah, Rachelle Goldfisher, John B Amodio
Takayasu Arteritis (TA) is an inflammatory disorder involving the thoracoabdominal aorta and its branches and the pulmonary arteries, with eventual vascular stenosis, occlusion, or aneurysm formation. Conventional angiography has been the reference imaging standard for diagnosis of TA. The purpose of this case report is to demonstrate the utility of MR imaging and MR angiography in the diagnosis of Takayasu Arteritis in a pediatric patient. The patient is a 15-year-old female patient presenting with anemia, hypertension, and acute kidney injury...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29105401/bioinformatic-analysis-identifies-three-potentially-key-differentially-expressed-genes-in-peripheral-blood-mononuclear-cells-of-patients-with-takayasu-s-arteritis
#6
Renping Huang, Yang He, Bei Sun, Bing Liu
OBJECTIVES: This study aimed to identify several potentially key genes associated with the pathogenesis of Takayasu's arteritis (TA). This identification may lead to a deeper mechanistic understanding of TA etiology and pave the way for potential therapeutic approaches. MATERIALS AND METHODS: In this experimental study, the microarray dataset GSE33910, which includes expression data for peripheral blood mononuclear cell (PBMC) samples isolated from TA patients and normal volunteers, was downloaded from the publicly accessible Gene Expression Omnibus (GEO) database...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29097042/clinical-characteristics-and-outcome-of-isolated-infrarenal-aortic-stenosis-in-young-patients
#7
Spyridon Monastiriotis, Shang Loh, Apostolos Tassiopoulos, Nicos Labropoulos
OBJECTIVE: The objective of this study was to identify young patients with isolated infrarenal aortic atherosclerotic stenosis and to determine the clinical characteristics and midterm results of angioplasty and stenting. METHODS: Data from patients younger than 50 years with significant infrarenal aortic stenosis and at least 1 year of follow-up were prospectively collected. Patients with coexistent suprarenal or iliofemoral disease and Takayasu arteritis were excluded...
October 30, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29096935/long-term-outcome-of-251-patients-with-takayasu-arteritis-on-combination-immunosuppressant-therapy-single-centre-experience-from-a-large-tertiary-care-teaching-hospital-in-southern-india
#8
Ruchika Goel, Debashish Danda, George Joseph, Raheesh Ravindran, Sathish Kumar, Visali Jayaseelan, Lakshmanan Jayaseelan, Paul Bacon
INTRODUCTION: Long-term outcome studies in Takayasu arteritis (TA) are few and limited by small sample size. In this study, we analysed the outcome of treatment in a large series of TA patients with a minimum follow-up period of ≥12 months by objective instruments. MATERIALS AND METHODS: Patients with TA satisfying the 1990 ACR, Ishikawa's, Sharma's or EULAR/PRESS criteria were recruited from our clinics between 1998 and 2016. Only patients with a minimum follow up of 12 months were studied...
September 30, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29082057/recovery-from-repeated-sudden-hearing-loss-in-a-patient-with-takayasu-s-arteritis-treated-with-hyperbaric-oxygen-therapy-the-first-report-in-the-literature
#9
Massimo Ralli, Antonio Greco, Vincenzo Falasca, Giancarlo Altissimi, Mario Tombolini, Rosaria Turchetta, Sara de Fazio, Marco de Vincentiis, Giancarlo Cianfrone
Hearing loss has been rarely reported in Takayasu's arteritis, may present as Sudden Sensorineural Hearing Loss, and usually responds well to corticosteroid therapy. Hyperbaric Oxygen Therapy is commonly used as a supplementary treatment to corticosteroids for Sudden Sensorineural Hearing Loss. We present the case of a 36-year-old woman with Takayasu's arteritis who had two episodes of sudden hearing loss involving one ear at a time with an 11-month delay between each episode. During the first episode, the patient was treated with high-dose intramuscular corticosteroids with a temporary improvement of auditory threshold that deteriorated 14 days after cessation of therapy...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29069518/current-and-emerging-therapies-in-large-vessel-vasculitis
#10
Tanaz A Kermani, Bhaskar Dasgupta
GCA shares many clinical features with PMR and Takayasu arteritis. The current mainstay of therapy for all three conditions is glucocorticoid therapy. Given the chronic, relapsing nature of these conditions and the morbidity associated with glucocorticoid therapy, there is a need for better treatment options to induce and sustain remission with fewer adverse effects. Conventional immunosuppressive treatments have been studied and have a modest effect. There is a keen interest in biologic therapies with studies showing the efficacy of IL-6 antagonists in PMR and GCA...
October 24, 2017: Rheumatology
https://www.readbyqxmd.com/read/29053795/rare-finding-in-takayasu-arteritis
#11
Ahmed M S E K Abdelaty, Eylem Levelt, Gerry P McCann
No abstract text is available yet for this article.
November 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29040156/accelerated-atheromatosis-and-arteriosclerosis-in-primary-systemic-vasculitides-current-evidence-and-future-perspectives
#12
Ourania D Argyropoulou, Athanase D Protogerou, Petros P Sfikakis
PURPOSE OF REVIEW: Primary systemic vasculitides (PSV) encompass a subset of autoimmune diseases, characterized by inflammation of blood vessels. Atheromatosis and arteriosclerosis may be accelerated in several PSV and account for the increased rate of cardiovascular morbidity that some exhibit. We aimed to summarize recent studies reporting on the acceleration of atheromatosis and/or arteriosclerosis in each type of PSV, using state-of-the-art noninvasive vascular biomarkers with clinical value as end points...
October 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29030659/cyclophosphamide-could-be-a-better-choice-than-methotrexate-as-induction-treatment-for-patients-with-more-severe-takayasu-s-arteritis
#13
Ying Sun, Lili Ma, Lingying Ma, Xiufang Kong, Huiyong Chen, Peng Lv, Jiang Lin, Hao Liu, Yan Yan, Zongfei Ji, Chengde Yang, Shengming Dai, Weiguo Wan, Yaohong Zou, Xuejuan Jin, Lindi Jiang
To assess the effectiveness of cyclophosphamide (CYC) versus methotrexate (MTX) for active Takayasu's arteritis (TA). The current study was based on a cohort of TA at Zhongshan Hospital, Fudan University. TA was diagnosed using the 1990 American College of Rheumatology criteria. Fifty-eight subjects receiving induction treatment with CYC (n = 46) or MTX (N = 12) were included in the analysis. Effectiveness and toxicity were assessed in all 58 cases. Clinical remission was defined as: Kerr score reduction to ≤ 1 and glucocorticoids (GC) treatment at a dose of ≤ 0...
December 2017: Rheumatology International
https://www.readbyqxmd.com/read/29024426/c-reactive-protein-gene-polymorphisms-rs1205-in-asian-indian-patients-with-takayasu-arteritis-associations-and-phenotype-correlations
#14
Aswin M Nair, Ruchika Goel, Mohan Hindhumati, Krati Shah, Puneet Chandana, Visalakshi Jayaseelan, Kabeerdoss Jayakanthan, George Joseph, Sumita Danda, Debashish Danda
BACKGROUND/PURPOSE: Normal C-reactive protein (CRP) in active Takayasu arteritis (TA) is a dilemma. We attempted to validate our pilot study finding of rs1205 in CRP gene being protective against TA. METHODS: Genomic DNA of 104 patients and 185 sex-matched healthy controls were genotyped for rs1205 by Taqman assay. Clinical details, demography, angiographic and activity scores (Indian Takayasu arteritis score 2010) were recorded prospectively at baseline and during follow-up visits for 12 months...
October 11, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28980910/health-related-outcomes-of-importance-to-patients-with-takayasu-s-arteritis
#15
Antoine G Sreih, Fatma Alibaz-Oner, Ebony Easley, Trocon Davis, Gonca Mumcu, Nataliya Milman, Joanna Robson, Haner Direskeneli, Peter A Merkel, Peter Cronholm
OBJECTIVES: The need to include patients' perspectives as key outcomes in clinical trials is widely accepted. No disease-specific patient-reported outcomes have been developed in Takayasu's arteritis. This project was designed to identify outcomes of importance to patients with Takayasu's arteritis during active disease and remission across 2 different cultures. METHODS: Patients with Takayasu's arteritis from the US and Turkey were recruited to participate in semi-structured, one-on-one interviews or focus groups...
September 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28977672/rituximab-therapy-for-takayasu-arteritis-a-seven-patients-experience-and-a-review-of-the-literature
#16
Giulia Pazzola, Francesco Muratore, Nicolò Pipitone, Filippo Crescentini, Patrice Cacoub, Luigi Boiardi, Lucia Spaggiari, Cloe Comarmond, Stefania Croci, David Saadoun, Carlo Salvarani
Objectives: To assess the efficacy and safety of rituximab (RTX) in patients with Takayasu arteritis (TAK). Methods: We conducted a retrospective study on seven TAK patients treated with RTX. Six of the seven patients had a disease refractory to high dose glucocorticoids and conventional immunosuppressive and/or biologic agents. One newly diagnosed, treatment-naïve TAK patient refused glucocorticoids and received RTX alone. Clinical evaluation, laboratory tests and imaging modalities (CT or MR-angiography, and 18 F-fluorodeoxyglucose PET/CT) were performed at first RTX administration and every 6 months thereafter...
July 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968895/discrepancies-between-vascular-and-systemic-inflammation-in-large-vessel-vasculitis-an-important-problem-revisited
#17
Gokhan Keser, Kenan Aksu, Haner Direskeneli
A lack of absolute correlation between systemic inflammation parameters and ongoing vascular disease activity is an important problem in some patients with large vessel vasculitis, especially Takayasu arteritis (TAK). Systemic and vascular wall inflammation in TAK are obviously interrelated, but sometimes they may act independently. There are clear discrepancies between these two types of inflammation, including cytokine patterns and responses to treatment. Vascular and systemic inflammation may also be discordant in two subgroups of giant cell arteritis...
September 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968808/assessment-of-the-frequency-of-cardiovascular-risk-factors-in-patients-with-takayasu-s-arteritis
#18
Fatma Alibaz-Oner, Matthew J Koster, Ali U Unal, Hale G Yildirim, Ceylan Çikikçi, Jean Schmidt, Cynthia S Crowson, Ashima Makol, Steven R Ytterberg, Eric L Matteson, Haner Direskeneli, Kenneth J Warrington
Objectives: The prevalence of atherosclerotic risk factors and disease in Takayasu's arteritis (TAK) has not been well defined. We aimed to assess the frequency of cardiovascular (CV) risk factors and the incidence of CV events (CVEs) in patients with TAK from two ethnically different populations. Methods: Patients with TAK followed at Mayo Clinic, Rochester, MN, USA and Marmara University, Istanbul, Turkey were included in this retrospective study. Patients with TAK were compared with age-, sex- and calendar year-matched controls from the same geographical region without TAK...
November 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968792/control-of-hiv-1-by-an-hla-b-52-01-c-12-02-protective-haplotype
#19
Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi
HLA-B*52:01-C*12:02, which is found in approximately 20 % of all Japanese, is well known to be associated with ulcerative colitis and Takayasu arteritis. This haplotype is also known to be a protective one in HIV-1-infective individuals. Recent studies showed that HLA-B*52:01-restricted HIV-1-specific T cells suppress HIV-1 and that HLA-C*12:02 together with KIR2DL2 play an important role in NK cell-mediated control of HIV-1. However, the role of HLA-C*12:02-restricted CTLs in suppression of HIV-1 replication remains unknown...
September 14, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968692/rituximab-in-takayasu-arteritis-an-unmet-hope
#20
Miguel A González-Gay, Santos Castañeda
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
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