keyword
https://read.qxmd.com/read/37032081/atypical-cogan-s-syndrome-with-large-vessel-vasculitis-successfully-treated-with-tocilizumab
#21
JOURNAL ARTICLE
Misako Higashida-Konishi, Mitsuhiro Akiyama, Hiroki Tabata, Satoshi Hama, Tatsuhiro Oshige, Keisuke Izumi, Hisaji Oshima, Yutaka Okano
A 61-year-old man presented with weight loss, bilateral ocular redness, blurred vision, and sensorineural hearing loss. Fluorodeoxyglucose-position emission tomography/computed tomography demonstrated an uptake in the ascending and descending aorta, abdominal aorta and femoral arteries. Atypical Cogan's syndrome complicated with large-vessel vasculitis (LVV) was diagnosed. He was treated with high-dose prednisolone and subcutaneous tocilizumab (162 mg/week), resulting in successful improvements in his ocular and vascular involvements...
April 7, 2023: Internal Medicine
https://read.qxmd.com/read/36914926/antenatal-ultrasound-features-of-isolated-recurrent-copy-number-variation-in-7q11-23-williams-syndrome-and-7q11-23-duplication-syndrome
#22
JOURNAL ARTICLE
Cécile Courdier, John Boudjarane, Valérie Malan, Christine Muti, Brian Sperelakis-Beedham, Sylvie Odent, Sylvie Jaillard, Chloé Quelin, Cédric Le Caignec, Olivier Patat, Charlotte Dubucs, Sophie Julia, Caroline Schluth-Bolard, Carole Goumy, Sylvia Redon, Jean-Baptiste Gaillard, Minh Tuan Huynh, Céline Dupont, Anne-Claude Tabet, Guillaume Cogan, François Vialard, Rodolphe Dard, Guillaume Jedraszak, Florence Jobic, Mathilde Lefebvre, Geneviève Quenum, Saori Inai, Mélanie Rama, Fanny Sauvestre, Frédéric Coatleven, Julie Thomas, Caroline Rooryck
OBJECTIVE: We aimed to gather fetal cases carrying a 7q11.23 copy number variation (CNV) and collect precise clinical data to broaden knowledge of antenatal features in these syndromes. METHODS: We retrospectively recruited unrelated cases with 7q11.23 deletion, known as Williams-Beuren syndrome (WBS), or 7q11.23 duplication who had prenatal ultrasound findings. We collected laboratory and clinical data, fetal ultrasound, cardiac ultrasound and fetal autopsy reports from 18 prenatal diagnostic centers throughout France...
June 2023: Prenatal Diagnosis
https://read.qxmd.com/read/36842941/cogan-syndrome-a-challenging-diagnosis
#23
JOURNAL ARTICLE
R Attia, N Stolowy, T Ruiz, L Dambricourt, T David
No abstract text is available yet for this article.
February 24, 2023: Journal Français D'ophtalmologie
https://read.qxmd.com/read/36659936/from-precise-diagnosis-to-effective-treatment-a-case-report-of-atypical-cogan-s-syndrome
#24
JOURNAL ARTICLE
Chu-Yuan Lou, Lu Lu, Xue-Xin Li
No abstract text is available yet for this article.
2023: International Journal of Ophthalmology
https://read.qxmd.com/read/36602160/intrathecal-injection-of-methotrexate-combined-with-dexamethasone-for-cogan-s-syndrome-with-neurological-involvement-a-case-report-and-literature-review
#25
Jiarui Hu, Hongjia Du, Jiang Su, Tong Wu, Rui Wu, Jing Zhu
Cogan's syndrome (CS) is a rare autoimmune disease in which approximately 10%-13% of people with the condition develop neurological symptoms. While glucocorticoids are the standard of care for patients with CS, disease-modifying anti-rheumatic drugs (DMARDs) and biologics agents are more widely used to treat the systemic and vestibular auditory manifestations of CS. Herein, we report a rare case of CS with central nervous system damage who failed to respond to systemic use of glucocorticoids and DMARDs. However, his symptoms were successfully improved by intrathecal injection of methotrexate (MTX) and dexamethasone...
January 5, 2023: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/36502531/report-of-2-pediatric-cases-with-atypical-cogan-s-syndrome-and-a-systematic-review
#26
Muserref Kasap Cuceoglu, Ozge Basaran, Ezgi Deniz Batu, Ummusen Kaya Akca, Erdal Atalay, Seher Sener, Zeynep Balik, Yagmur Bayindir, Emil Aliyev, Rahsan Gocmen, Sibel Kadayifcilar, Umut Akyol, Yelda Bilginer, Seza Ozen
Cogan's syndrome (CS) is a rare inflammatory disease characterized by interstitial keratitis or uveitis, vestibular impairment, and progressive hearing loss, commonly bilateral. Although glucocorticoids are fundamental treatment options, in most cases, hearing loss gradually worsens. Herein we report 2 pediatric cases of CS who were treated with corticosteroids and methotrexate. One patient had a cochlear implant, and the hearing of the other patient improved with treatment. Also, a systematic literature review was conducted for articles including pediatric CS patients...
December 11, 2022: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/36415844/aortitis-secondary-to-cogan-s-syndrome-a-rare-cause-of-fever-of-unknown-origin
#27
JOURNAL ARTICLE
Maria Margarida Rosado, Cláudia Queirós, Vanda Conceição, Nuno Bernardino Vieira, Luísa Arez
UNLABELLED: Fever of unknown origin remains a diagnostic challenge. Aortitis, defined as inflammation of the aorta, has multiple infectious and non-infectious causes. We report the case of an elderly woman with vertigo and bilateral hearing loss, presenting with fever of unknown origin. Blood tests were remarkable for leucocytosis with neutrophilia, elevation of C-reactive protein and the erythrocyte sedimentation rate, and positive antinuclear antibodies and rheumatoid factor, and an unremarkable search for multiple infectious causes of fever...
2022: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/36286971/-non-infectious-diseases-of-the-aorta-and-large-arteries
#28
JOURNAL ARTICLE
T V Beketova
This article describes the various forms of inflammatory lesions of the aorta and large arteries, including chronic periaortitis, as well as the diagnostic methods are considered. Large vessel vasculitis represent the most common entities, however, there is also an association with other rheumatological or inflammatory diseases, drug-induced or paraneoplastic entities. Instrumental imaging modalities play an important role in the diagnosis.
June 17, 2022: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/36200117/iridocorneal-endothelial-syndrome-case-report-of-essential-progressive-iris-atrophy
#29
Allen Popovic Beganovic, Amra Nadarevic Vodencarevic, Meliha Halilbasic, Anis Medjedovic
Background: Iridocorneal endothelial (ICE) syndrome is a group of ophthalmic disorders, first reported by Eagle and Yanoff in 1979, a disease characterized by abnormalities of the iris and the corneal endothelium, and mainly occurs unilaterally in young and middle-aged women, with no family history. ICE syndrome comprises a spectrum of three clinical variants: Progressive essential iris atrophy (corectopia, iris atrophy or iris hole), Chandler syndrome (corneal oedema with mild to absent iris change), and Cogan - Reese syndrome (nodular pigmented lesion of the iris)...
June 2022: Medical Archives
https://read.qxmd.com/read/36151850/resource-utilization-and-multidisciplinary-care-needs-for-patients-with-ehlers-danlos-syndrome
#30
JOURNAL ARTICLE
Jordan T Jones, William R Black, Wendy Cogan, Elisabeth Callen
BACKGROUND: Ehlers-Danlos syndrome (EDS) represents a family of heritable connective tissue disorders with overlapping phenotypic features, frequently including joint hypermobility, tissue fragility, and skin hyperextensibility. Comorbid symptoms are common for patients with EDS and include multiple body systems marked by neurologic, cardiovascular, gastrointestinal, musculoskeletal issues, chronic pain, headaches, and anxiety and depression. The many comorbidities lead to high disease burden, which requires greater healthcare utilization...
November 2022: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/36146663/mucin-transiently-sustains-coronavirus-infectivity-through-heterogenous-changes-in-phase-morphology-of-evaporating-aerosol
#31
JOURNAL ARTICLE
Robert W Alexander, Jianghan Tian, Allen E Haddrell, Henry P Oswin, Edward Neal, Daniel A Hardy, Mara Otero-Fernandez, Jamie F S Mann, Tristan A Cogan, Adam Finn, Andrew D Davidson, Darryl J Hill, Jonathan P Reid
Respiratory pathogens can be spread though the transmission of aerosolised expiratory secretions in the form of droplets or particulates. Understanding the fundamental aerosol parameters that govern how such pathogens survive whilst airborne is essential to understanding and developing methods of restricting their dissemination. Pathogen viability measurements made using Controlled Electrodynamic Levitation and Extraction of Bioaerosol onto Substrate (CELEBS) in tandem with a comparative kinetics electrodynamic balance (CKEDB) measurements allow for a direct comparison between viral viability and evaporation kinetics of the aerosol with a time resolution of seconds...
August 24, 2022: Viruses
https://read.qxmd.com/read/36127273/easy-miss-early-cogan-reese-syndrome
#32
JOURNAL ARTICLE
Kajree Gupta, Sushmita Kaushik, Ashok Kumar Singh
No abstract text is available yet for this article.
September 17, 2022: Ophthalmology Glaucoma
https://read.qxmd.com/read/35950024/iris-nevus-cogan-reese-syndrome-presenting-with-zonular-dehiscence-during-cataract-extraction
#33
Priyanka Chhadva, Maria Del Valle Estopinal, Marjan Farid
The aim of this study was to report a novel presentation of Cogan-Reese syndrome presenting with zonular dehiscence during cataract extraction with intraocular lens placement. A 49-year-old woman presented with worsening vision over 2 years. The examination was significant for bilateral pupil miosis, visually significant cataracts, and unilateral glaucoma. No iris nodules or corneal endothelial disease was observed through slit-lamp examination and specular microscopy bilaterally. Cataract extraction on the left eye was complicated by significant zonular dehiscence...
May 2022: Case Reports in Ophthalmology
https://read.qxmd.com/read/35899725/-vertigo-and-ocular-inflammation-cogan-syndrome
#34
JOURNAL ARTICLE
W Ron P J van Oosterhout, Joep W G Stroomer, G Rik H J Rösken
BACKGROUND: Cogan syndrome is a rare inflammatory condition that mainly affects adults and is characterised by inflammation of various ocular structures and by audiovestibular symptoms such as hearing loss and vertigo. CASE DESCRIPTION: A 63-year old woman recently diagnosed with an anterior uveitis presented at A&E with vertigo, nausea, vomiting, tinnitus and headache, and she developed bilateral sudden deafness within days. Blood testing revealed elevated inflammatory parameters, without signs of infection...
July 21, 2022: Nederlands Tijdschrift Voor Geneeskunde
https://read.qxmd.com/read/35881997/posterior-scleritis-a-unique-sequela-of-cogan-syndrome
#35
JOURNAL ARTICLE
Nicole Lifson, Viren Rana, Lewena Maher, Lory Snady-McCoy
No abstract text is available yet for this article.
August 1, 2022: Rhode Island Medical Journal
https://read.qxmd.com/read/35880512/a-giant-silence-an-atypical-association-of-sensorineural-hearing-loss-with-giant-cell-arteritis
#36
Yu Feng Shi, Sameer Malik
Giant cell arteritis (GCA) is a chronic vasculitic disorder predominantly affecting medium to large sized arteries, prevalent in the 50 plus age group. This case illustrates an atypical presentation of this disease in the form of bilateral sensorineural hearing loss (SNHL). Apart from the presence of constitutional and vertiginous symptoms, there were essentially no classical features of GCA. Differentials were broad including infection, malignancy and medication toxicity as well as brain, eye and ear syndromes such as Cogan's syndrome, all of which were eventually excluded...
July 26, 2022: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/35834480/sars-cov-2-spike-and-nucleocapsid-proteins-fail-to-activate-human-dendritic-cells-or-%C3%AE-%C3%AE-t-cells
#37
JOURNAL ARTICLE
Kiran Singh, Sita Cogan, Stefan Elekes, Dearbhla M Murphy, Sinead Cummins, Rory Curran, Zaneta Najda, Margaret R Dunne, Gráinne Jameson, Siobhan Gargan, Seamus Martin, Aideen Long, Derek G Doherty
γδ T cells are thought to contribute to immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus are unknown. Using flow cytometry, we investigated if the two most abundant viral structural proteins, spike and nucleocapsid, can activate human γδ T cell subsets, directly or in the presence of dendritic cells (DC). Both proteins failed to induce interferon-γ production by Vδ1 or Vδ2 T cells within fresh mononuclear cells or lines of expanded γδ T cells generated from healthy donors, but the same proteins stimulated CD3+ cells from COVID-19 patients...
2022: PloS One
https://read.qxmd.com/read/35791196/electron-microscopy-in-cogan-reese-syndrome
#38
JOURNAL ARTICLE
Geeta Behera, Tapas C Nag, Sudarshan K Khokhar, Suneel Sangaraju
No abstract text is available yet for this article.
July 2022: Indian Journal of Ophthalmology
https://read.qxmd.com/read/35763573/the-dynamics-of-sars-cov-2-infectivity-with-changes-in-aerosol-microenvironment
#39
JOURNAL ARTICLE
Henry P Oswin, Allen E Haddrell, Mara Otero-Fernandez, Jamie F S Mann, Tristan A Cogan, Thomas G Hilditch, Jianghan Tian, Daniel A Hardy, Darryl J Hill, Adam Finn, Andrew D Davidson, Jonathan P Reid
Understanding the factors that influence the airborne survival of viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets (∼5 to 10 µm equilibrated radius) over timescales spanning 5 s to 20 min using an instrument to probe survival in a small population of droplets (typically 5 to 10) containing ∼1 virus/droplet...
July 5, 2022: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/35720358/case-report-comorbid-hyper-igd-syndrome-and-hidradenitis-suppurativa-a-new-syndromic-form-of-hs-a-report-of-two-cases
#40
Philippe Guillem, Dillon Mintoff, Mariam Kabbani, Elie Cogan, Virginie Vlaeminck-Guillem, Agnes Duquesne, Farida Benhadou
Hidradenitis Suppurativa (HS) is a chronic suppurative disease of the pilosebaceous unit. The current model of HS pathophysiology describes the condition as the product of hyperkeratinisation and inflammation at the hair follicular unit. Environmental factors (such as smoking and obesity), gender, genetic predisposition, and skin dysbiosis are considered the main pathogenic drivers of the disease. Autoinflammatory syndromes associated with HS are rare but may help to highlight the potential roles of autoinflammation and dysregulated innate immune system in HS...
2022: Frontiers in Immunology
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