Edith Schneider, Nicole Pochert, Christoph Ruess, Liam MacPhee, Leo Escano, Christina Miller, Kathrin Krowiorz, Erik Delsing Malmberg, Alireza Heravi-Moussavi, Alireza Lorzadeh, Arghavan Ashouri, Sarah Grasedieck, Nadine Sperb, Pradeep Kumar Kopparapu, Sebastian Iben, Anna Staffas, Ping Xiang, Reinhild Rösler, Meena Kanduri, Erik Larsson, Linda Fogelstrand, Hartmut Döhner, Konstanze Döhner, Sebastian Wiese, Martin Hirst, R Keith Humphries, Lars Palmqvist, Florian Kuchenbauer, Arefeh Rouhi
MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes balance self-renewal, proliferation, cell death, and differentiation in many tissues and aberrant Hox gene expression can create a predisposition to leukemogenesis in hematopoietic cells. However, possible linkages between the regulatory pathways of Hox genes and miRNAs are not yet fully resolved. We identified miR-708 to be upregulated in Hoxa9/Meis1 AML inducing cell lines as well as in AML patients...
November 25, 2019: Leukemia