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Pranav Tiwari, Sakshi Agarwal, Sachchidanand Srivastava, Shilpee Jain
Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems and studied their candidacy for cancer treatment. The polycaprolactone-Fe3 O4 based MAST fibers were fabricated using electrospinning technique. These MAST fibrous systems contained carbogenic quantum dots as a tracking agent and doxorubicin hydrochloride anticancer drug. Additionally, as fabricated MAST fibrous systems were able to deliver anticancer drug and heat energy simultaneously to kill HeLa cells in a 10 min period in vitro...
January 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Akram R Jabur
Chitosan/nylon-6 nanofibres with antibacterial activity properties were prepared by electrospinning a chitosan/nylon-6 solution (containing medium molecular weight chitosan). Nanofibres with diameters in the range of 139-190 nm were obtained. The yield of low concentration chitosan/nylon-6 nanofibres was higher than that of high concentration chitosan/nylon-6 nanofibres. The affinity of chitosan toward lead was studied using a Pb(NO3)2 solution containing Pb(II) ions as the heavy metal solution. The rejection of lead ions by the chitosan/nylon membranes was investigated under various chitosan concentrations...
December 7, 2017: Biomedical Materials
Sang Min Park, Seongsu Eom, Wonkyoung Kim, Dong Sung Kim
Liquid collectors are applicable as ground collectors in electrospinning, which fabricates complex nanofiber architectures. However, the influence of the electrical properties of liquid collectors on the controlled deposition of electrospun nanofiber mats has received little attention. Here we prepare two types of liquid collectors (electrolyte solutions and dielectric liquids) and newly scrutinize their roles in the patterning of electrospun nanofiber mats in experiments and numerical simulations. By simulating the concentrations of the electric fields around the liquid collectors, we indirectly evaluated the patternability of the collectors...
December 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
N Abdullah, S K Kamarudin, L K Shyuan, N A Karim
Platinum (Pt) is the common catalyst used in a direct methanol fuel cell (DMFC). However, Pt can lead towards catalyst poisoning by carbonaceous species, thus reduces the performance of DMFC. Thus, this study focuses on the fabrication of a new composite TiO2 carbon nanofiber anodic catalyst support for direct methanol fuel cells (DMFCs) via electrospinning technique. The distance between the tip and the collector (DTC) and the flow rate were examined as influencing parameters in the electrospinning technique...
December 6, 2017: Nanoscale Research Letters
Young-Gwang Ko, Young-Jin Kim, Won Ho Park, Donghwan Cho, Ho Yun Chung, Oh Hyeong Kwon
To maintain the original function of a specific tissue for therapeutic tissue engineering, an advanced cell culture surface for repeat cell proliferation is necessary. We designed a novel cell proliferation and rapid harvesting surface by combining nonwoven nanofiber mat and a thermo-responsive polymer. Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) mats were fabricated by the electrospinning technique. A poly(N-isopropylacrylamide) (PNIPAM) thermo-responsive layer was grafted on the PHBV nanofiber mat by electron beam irradiation...
December 7, 2017: Journal of Biomaterials Science. Polymer Edition
Hui-Ching Hsieh, Jung-Yao Chen, Wen-Ya Lee, Debaditya Bera, Wen-Chang Chen
Stretchable light-emitting polymers are important for wearable electronics; however, the development of intrinsic stretchable light-emitting materials with great performance under large applied strain is the most critical challenge. Herein, this study demonstrates the fabrication of stretchable fluorescent poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctyl-fluorene)]/acrylonitrile butadiene rubber (PFN/NBR) blend nanofibers using the uniaxial electrospinning technique. The physical interaction of PFN with NBR and the geometrical confinement of nanofibers are employed to reduce PFN aggregation, leading to the high photoluminescence quantum yield of 35...
December 6, 2017: Macromolecular Rapid Communications
Chengkai Lin, Chang Liu, Liangming Zhang, Zhi Huang, Peipei Zhao, Ruiqiang Chen, Mao Pang, Zhenxiang Chen, Liumin He, Chunxiao Luo, Limin Rong, Bin Liu
Tissue engineering is a rapidly growing technological area for the regeneration and reconstruction of damage to the central nervous system. By combining seed cells with appropriate biomaterial scaffolds, tissue engineering has the ability to improve nerve regeneration and functional recovery. In the present study, mouse induced pluripotent stem cells (iPSCs) were generated from mouse embryonic fibroblasts (MEFs) with the non-integrating episomal vectors pCEP4-EO2S-ET2K and pCEP4-miR-302-367 cluster, and differentiated into neural stem cells (NSCs) as transplanting cells...
November 30, 2017: International Journal of Molecular Medicine
Mohammad Ali Salami, Faranak Kaveian, Mohammad Rafienia, Saeed Saber-Samandari, Amirsalar Khandan, Mitra Naeimi
Background: Biopolymer scaffolds have received great interest in academic and industrial environment because of their supreme characteristics like biological, mechanical, chemical, and cost saving in the biomedical science. There are various attempts for incorporation of biopolymers with cheap natural micro- or nanoparticles like lignin (Lig), alginate, and gums to prepare new materials with enhanced properties. Methods: In this work, the electrospinning (ELS) technique as a promising cost-effective method for producing polymeric scaffold fibers was used, which mimics extracellular matrix structure for soft tissue engineering applications...
October 2017: Journal of Medical Signals and Sensors
Tongfei Li, Yinjie Lv, Jiahui Su, Yi Wang, Qian Yang, Yiwei Zhang, Jiancheng Zhou, Lin Xu, Dongmei Sun, Yawen Tang
The exploration of earth-abundant and high-efficiency electrocatalysts for the oxygen evolution reaction (OER) is of great significant for sustainable energy conversion and storage applications. Although spinel-type binary transition metal oxides (AB2O4, A, B = metal) represent a class of promising candidates for water oxidation catalysis, their intrinsically inferior electrical conductivity exert remarkably negative impacts on their electrochemical performances. Herein, we demonstrates a feasible electrospinning approach to concurrently synthesize CoFe2O4 nanoparticles homogeneously embedded in 1D N-doped carbon nanofibers (denoted as CoFe2O4@N-CNFs)...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Anthony R D'Amato, Nicholas J Schaub, Jesus M Cardenas, Andrew S Fiumara, Paul M Troiano, Andrea Fischetti, Ryan J Gilbert
A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small molecule drugs from electrospun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small molecule drug, 6-aminonicotinamide (6AN), from PLLA fibers...
August 11, 2017: Polymer
Hossein Mahboudi, Bahram Kazemi, Masoud Soleimani, Hana Hanaee-Ahvaz, Hossein Ghanbarian, Mojgan Bandehpour, Seyed Ehsan Enderami, Mousa Kehtari, Ghasem Barati
Mesenchymal stem cells (MSC) from bone marrow hold great potential as a cell source for cartilage repair. The objective of our study was differentiation of MSC toward chondrocyte by using Nanofiber-based polyethersulfone (PES) scaffold and also enhanced chondrogenic differentiation of BMSC in vitro. MSCs were harvested from bone marrow of human and PES scaffold was fabricated via Electrospinning. The isolated cells were cultured on the PES scaffold and scaffold free method. After 21days, Real-time PCR was performed to evaluate the cartilage-specific genes in the mRNA levels...
November 29, 2017: Gene
A Shababdoust, M Ehsani, P Shokrollahi, M Zandi
Two series of polyurethane (PU), based on polycaprolactone (PCL) as soft segments with two different molecular weights (2000 and 530 Da), and hexamethylene diisocyanate (HDI) and 1,4-butandiol (BDO) as hard segments were synthesized to fabricate curcumin-loaded electrospun nanofibrous PCL-based PU substrate. Chemical structures of the synthesized PUs were characterized by FTIR and NMR spectroscopy techniques. The thermal properties were analyzed by differential scanning calorimetry (DSC) and surface hydrophilicity was studied by static contact angle and bulk hydrophilicity was evaluated by water uptake test...
December 1, 2017: Progress in Biomaterials
Nilay Tam, Seren Oguz, Ayca Aydogdu, Gulum Sumnu, Serpil Sahin
Electrospinning is a method used in fiber production in which an electric force is applied to create jets of charged polymer solutions. The objective of this study was to obtain homogeneous nanofibers from lentil flour and hydroxypropyl methylcellulose (HPMC) blend by using electrospinning method. Distilled water was used as solvent. The effects of pH (7, 10 and 12), lentil flour concentration (1% and 2% (w/v)) and HPMC concentration (0.25%, 0.5% and 1% (w/v)) on solution properties and fiber morphology were investigated...
December 2017: Food Research International
Chien-You Su, An-Chih Yang, Jung-Shiun Jiang, Zhi-Huei Yang, Yan-Shu Huang, Dun-Yen Kang, Chi-Chung Hua
The properties of (synthesized) single-walled aluminosilicate nanotube (AlSiNT; light-scattering characterized length ~2000 ± 230 nm and diameter ~35 ± 4 nm ) dispersed in an aqueous poly(vinyl alcohol) (PVA) solution (10 wt%) are systematically explored using a comprehensive combination of (polarized/depolarized) dynamic light scattering, rheological, rheo-optical, and scanning electron microscopy analysis schemes. The nanotube/polymer dispersions under investigation are promising for their fair nanotube dispersion in pristine aqueous media (e...
December 1, 2017: Journal of Physical Chemistry. B
Jun Hee Kim, Mahesh Kumar Joshi, Joshua Lee, Chan Hee Park, Cheol Sang Kim
Depositing of hierarchical ZnO nanostructures on electrospun nanofibers and their proper attachment has gained significant interest for myriad applications. However, the weak attachment of such nanostructures to the nanofiber surface limits their practical applications. In this study, a simple and efficient method has been developed for preparing hierarchical ZnO nanorod deposited polyurethane (PU) nanofiber by combining electrospinning, surface functionalization and hydrothermal treatment. Electrospun PU nanofibers were coated with polydopamine (Pdopa) via dip coating method...
November 21, 2017: Journal of Colloid and Interface Science
Vincent Pertici, Guillaume Martrou, Didier Gigmes, Thomas Trimaille
BACKGROUND: Over the last decades, synthetic polymer-based electrospun nano/microfibers have emerged as potent materials in crucial biomedical applications such as tissue engineering, drug delivery and diagnostics. This is mainly attributed to versatility and reproducibility of the electrospinning (ES) process, as well as the high surface-to-volume ratio of the generated nanostructures. Appropriate functionalization with dedicated biomolecules (i.e. cell adhesive peptides, therapeutic molecules, bio-probes) is a critical requirement for the performances of such materials in their related application...
November 29, 2017: Current Medicinal Chemistry
Chuan Fu, Haotian Bai, Jiaqi Zhu, Zhihao Niu, Yu Wang, Jianan Li, Xiaoyu Yang, Yunshen Bai
One of the goals of bone tissue engineering is to mimic native ECM in architecture and function, creating scaffolds with excellent biocompatibility, osteoinductive ability and mechanical properties. The aim of this study was to fabricate nanofibrous matrices by electrospinning a blend of poly (L-lactic-co-glycolic acid) (PLGA), hydroxyapatite (HA), and grapheme oxide (GO) as a favourable platform for bone tissue engineering. The morphology, biocompatibility, mechanical properties, and biological activity of all nanofibrous matrices were compared...
2017: PloS One
Maziar Ghazinejad, Sunshine Holmberg, Oscar Pilloni, Laura Oropeza-Ramos, Marc Madou
Graphitic carbons' unique attributes have attracted worldwide interest towards their development and application. Carbon pyrolysis is a widespread method for synthesizing carbon materials. However, our understanding of the factors that cause differences in graphitization of various pyrolyzed carbon precursors is inadequate. We demonstrate how electro-mechanical aspects of the synthesis process influence molecular alignment in a polymer precursor to enhance its graphitization. Electrohydrodynamic forces are applied via electrospinning to unwind and orient the molecular chains of a non-graphitizing carbon precursor, polyacrylonitrile...
November 29, 2017: Scientific Reports
WooSeok Choi, Geon Hwee Kim, Jung Hwal Shin, Geunbae Lim, Taechang An
We report a simple method for electrospinning polymers onto flexible, insulating substrates by controlling the wettability of the substrate surface. Water molecules were adsorbed onto the surface of a hydrophilic polymer substrate by increasing the local humidity around the substrate. The adsorbed water was used as the ground electrode for electrospinning. The electrospun fibers were deposited only onto hydrophilic areas of the substrate, allowing for patterning through wettability control. Direct writing of polymer fiber was also possible through near-field electrospinning onto a hydrophilic surface...
November 28, 2017: Nanoscale Research Letters
Zetao Ding, Qingqing Cheng, Liangliang Zou, Jianhui Fang, Zhiqing Zou, Hui Yang
Chemical and electrochemical corrosion of a support limits the corresponding catalyst's performance and lifetime. In this paper, uniform TiN nanotubes are synthesized via coaxial-electrospinning, thermal oxidation and nitridation. The average diameter of nanotubes can be facilely controlled by tuning the parameters of coaxial electrospinning. The TiN nanotubes are modified further with Pt nanoparticles as Pt/TiN NT electrocatalysts. After accelerated durability tests, the electrochemical surface area (ECSA) and mass activity of the Pt/TiN decrease by only 6% and 14% respectively, while those of the Pt/C decrease by 44% and 46...
November 28, 2017: Chemical Communications: Chem Comm
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