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https://www.readbyqxmd.com/read/27599447/ammonium-accumulation-is-a-primary-effect-of-2-methylcitrate-exposure-in-an-in-vitro-model-for-brain-damage-in-methylmalonic-aciduria
#1
Hong-Phuc Cudré-Cung, Petra Zavadakova, Sónia do Vale-Pereira, Noémie Remacle, Hugues Henry, Julijana Ivanisevic, Denise Tavel, Olivier Braissant, Diana Ballhausen
Using 3D organotypic rat brain cell cultures in aggregates we recently identified 2-methylcitrate (2-MCA) as the main toxic metabolite for developing brain cells in methylmalonic aciduria. Exposure to 2-MCA triggered morphological changes and apoptosis of brain cells. This was accompanied by increased ammonium and decreased glutamine levels. However, the sequence and causal relationship between these phenomena remained unclear. To understand the sequence and time course of pathogenic events, we exposed 3D rat brain cell aggregates to different concentrations of 2-MCA (0...
September 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27479079/mild-alkalization-acutely-triggers-the-warburg-effect-by-enhancing-hexokinase-activity-via-voltage-dependent-anion-channel-binding
#2
Cung Hoa Thien Quach, Kyung-Ho Jung, Jin Hee Lee, Jin Won Park, Seung Hwan Moon, Young Seok Cho, Yearn Seong Choe, Kyung-Han Lee
To fully understand the glycolytic behavior of cancer cells, it is important to recognize how it is linked to pH dynamics. Here, we evaluated the acute effects of mild acidification and alkalization on cancer cell glucose uptake and glycolytic flux and investigated the role of hexokinase (HK). Cancer cells exposed to buffers with graded pH were measured for 18F-fluorodeoxyglucose (FDG) uptake, lactate production and HK activity. Subcellular localization of HK protein was assessed by western blots and confocal microscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27182706/exome-sequencing-identifies-a-novel-lmna-splice-site-mutation-and-multigenic-heterozygosity-of-potential-modifiers-in-a-family-with-sick-sinus-syndrome-dilated-cardiomyopathy-and-sudden-cardiac-death
#3
Michael V Zaragoza, Lianna Fung, Ember Jensen, Frances Oh, Katherine Cung, Linda A McCarthy, Christine K Tran, Van Hoang, Simin A Hakim, Anna Grosberg
The goals are to understand the primary genetic mechanisms that cause Sick Sinus Syndrome and to identify potential modifiers that may result in intrafamilial variability within a multigenerational family. The proband is a 63-year-old male with a family history of individuals (>10) with sinus node dysfunction, ventricular arrhythmia, cardiomyopathy, heart failure, and sudden death. We used exome sequencing of a single individual to identify a novel LMNA mutation and demonstrated the importance of Sanger validation and family studies when evaluating candidates...
2016: PloS One
https://www.readbyqxmd.com/read/27021851/is-there-a-difference-in-efficacy-safety-and-cost-effectiveness-between-3-factor-and-4-factor-prothrombin-complex-concentrates-among-trauma-patients-on-oral-anticoagulants
#4
Alicia Mangram, Olakunle F Oguntodu, James K Dzandu, Alexzandra K Hollingworth, Scott Hall, Christina Cung, Jason Rodriguez, Igor Yusupov, Jeffrey F Barletta
PURPOSE: The aim of this study was to compare the efficacy, safety, and cost-effectiveness of 3-factor prothrombin complex concentrate (3F-PCC) vs 4-factor prothrombin complex concentrate PCC (4F-PCC) in trauma patients requiring reversal of oral anticoagulants. MATERIALS AND METHODS: All consecutive trauma patients with coagulopathy (international normalized ratio [INR] ≥1.5) secondary to oral anticoagulants who received either 3F-PCC or 4F-PCC from 2010 to 2014 at 2 trauma centers were reviewed...
June 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/26817755/outcomes-after-cryoablation-vs-radiofrequency-in-patients-with-paroxysmal-atrial-fibrillation-impact-of-pulmonary-veins-anatomy
#5
Z Khoueiry, J-P Albenque, R Providencia, S Combes, N Combes, F Jourda, P A Sousa, C Cardin, J-L Pasquie, T T Cung, F Massin, E Marijon, S Boveda
AIMS: Pulmonary vein isolation is the mainstay of treatment in catheter ablation of paroxysmal atrial fibrillation (AF). Cryoballoon ablation has been introduced more recently than radiofrequency ablation, the standard technique in most centres. Pulmonary veins frequently display anatomical variants, which may compromise the results of cryoballoon ablation. We aimed to evaluate the mid-term outcomes of cryoballoon ablation in an unselected population with paroxysmal AF from an anatomical viewpoint...
September 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26654204/degradation-of-sec-hexylbenzene-and-its-metabolites-by-a-biofilm-forming-yeast-trichosporon-asahii-b1-isolated-from-oil-contaminated-sediments-in-quangninh-coastal-zone-vietnam
#6
Le Thi Nhi-Cong, Cung Thi Ngoc Mai, Nghiem Ngoc Minh, Hoang Phuong Ha, Do Thi Lien, Do Van Tuan, Dong Van Quyen, Michihiko Ike, Do Thi To Uyen
This article reports on the ability of yeast Trichosporon asahii B1 biofilm-associated cells, compared with that of planktonic cells, to transform sec-hexylbenzene and its metabolites. This B1 strain was isolated from a petroleum-polluted sediment collected in the QuangNinh coastal zones in Vietnam, and it can transform the branched aromatic hydrocarbons into a type of forming biofilm (pellicle) more efficiency than that the planktonic forms can. In the biofilm cultivation, seven metabolites, including acetophenone, benzoic acid, 2,3-dihydroxybenzoic acid, β-methylcinnamic acid, 2-phenylpropionic acid, 3-phenylbutyric acid, and 5-phenylhexanoic acid were extracted by ethyl acetate and analyzed by HPLC and GC-MS...
2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/26449833/troglitazone-stimulates-cancer-cell-uptake-of-18f-fdg-by-suppressing-mitochondrial-respiration-and-augments-sensitivity-to-glucose-restriction
#7
Seung-Hwan Moon, Su Jin Lee, Kyung-Ho Jung, Cung Hoa Thien Quach, Jin-Won Park, Jin Hee Lee, Young Seok Cho, Kyung-Han Lee
UNLABELLED: We evaluated how troglitazone influences cancer cell glucose metabolism and uptake of (18)F-FDG, and we investigated its molecular mechanism and relation to the drug's anticancer effect. METHODS: Human T47D breast and HCT116 colon cancer cells that had been treated with troglitazone were measured for (18)F-FDG uptake, lactate release, oxygen consumption rate, mitochondrial membrane potential, and intracellular reactive oxygen species. Viable cell content was measured by sulforhodamine-B assays...
January 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26360873/cephalometry-in-adults-and-children-with-neurofibromatosis-type-1-implications-for-the-pathogenesis-of-sphenoid-wing-dysplasia-and-the-nf1-facies
#8
Winnie Cung, Laura A Freedman, Nicholas E Khan, Elaine Romberg, Pamela J Gardner, Carol W Bassim, Andrea M Baldwin, Brigitte C Widemann, Douglas R Stewart
BACKGROUND: Neurofibromatosis type 1 (NF1) is a common, autosomal dominant tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1. Cephalometry is an inexpensive, readily available and non-invasive technique that is under-utilized in studying the NF1 craniofacial phenotype. An analysis of NF1 cephalometry was first published by Heervä et al. in 2011. We expand here on that first investigation with a larger cohort of adult and pediatric patients affected with NF1 and sought objective insight into the NF1 facies, said to feature hypertelorism and a broad nasal base, from cephalometric analysis...
November 2015: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/26338893/spect-myocardial-perfusion-reserve-in-patients-with-multivessel-coronary-disease-correlation-with-angiographic-findings-and-invasive-fractional-flow-reserve-measurements
#9
Fayçal Ben Bouallègue, François Roubille, Benoit Lattuca, Thien Tri Cung, Jean-Christophe Macia, Richard Gervasoni, Florence Leclercq, Denis Mariano-Goulart
UNLABELLED: Quantification of myocardial perfusion reserve (MPR) is an emerging topic in nuclear cardiology with an expected diagnostic and prognostic incremental value, especially for patients with severe coronary artery disease. The advent of new dedicated solid-state cameras has opened new perspectives for perfusion quantitation in SPECT. We appraised the feasibility of perfusion reserve estimation using a cadmium zinc telluride camera in a cohort of multivessel patients and its pertinence with respect to angiographic data...
November 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26321103/cyclosporine-before-pci-in-patients-with-acute-myocardial-infarction
#10
RANDOMIZED CONTROLLED TRIAL
Thien-Tri Cung, Olivier Morel, Guillaume Cayla, Gilles Rioufol, David Garcia-Dorado, Denis Angoulvant, Eric Bonnefoy-Cudraz, Patrice Guérin, Meier Elbaz, Nicolas Delarche, Pierre Coste, Gerald Vanzetto, Marc Metge, Jean-François Aupetit, Bernard Jouve, Pascal Motreff, Christophe Tron, Jean-Noel Labeque, Philippe Gabriel Steg, Yves Cottin, Grégoire Range, Jérome Clerc, Marc J Claeys, Patrick Coussement, Fabrice Prunier, Frédéric Moulin, Olivier Roth, Loïc Belle, Philippe Dubois, Paul Barragan, Martine Gilard, Christophe Piot, Patrice Colin, Fabien De Poli, Marie-Claude Morice, Omar Ider, Jean-Luc Dubois-Randé, Thierry Unterseeh, Hervé Le Breton, Thierry Béard, Didier Blanchard, Gilles Grollier, Vincent Malquarti, Patrick Staat, Arnaud Sudre, Eskil Elmer, Magnus J Hansson, Cyrille Bergerot, Inesse Boussaha, Claire Jossan, Geneviève Derumeaux, Nathan Mewton, Michel Ovize
BACKGROUND: Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling. METHODS: In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation myocardial infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset and who had complete occlusion of the culprit coronary artery to receive a bolus injection of cyclosporine (administered intravenously at a dose of 2...
September 10, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26116981/pre-pci-angiographic-timi-flow-in-the-culprit-coronary-artery-influences-infarct-size-and-microvascular-obstruction-in-stemi-patients
#11
Mathieu Julien Schaaf, Nathan Mewton, Gilles Rioufol, Denis Angoulvant, Guillaume Cayla, Nicolas Delarche, Bernard Jouve, Patrice Guerin, Gerald Vanzetto, Pierre Coste, Olivier Morel, François Roubille, Meyer Elbaz, Olivier Roth, Fabrice Prunier, Thien Tri Cung, Christophe Piot, Ingrid Sanchez, Eric Bonnefoy-Cudraz, Didier Revel, Céline Giraud, Pierre Croisille, Michel Ovize
OBJECTIVE: The influence of initial-thrombolysis in myocardial infarction (i-TIMI) coronary flow in the culprit coronary artery on myocardial infarct and microvascular obstruction (MVO) size is unclear. We assessed the impact on infarct size of i-TIMI flow in the culprit coronary artery, as well as on MVO incidence and size, by contrast-enhanced cardiac magnetic resonance (ce-CMR). METHODS: In a prospective, multicenter study, pre-percutaneous coronary intervention (PCI) coronary occlusion was defined by an i-TIMI flow ≤1, and patency was defined by an i-TIMI flow ≥2...
March 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/26027612/rationale-and-design-of-the-cyclosporine-to-improve-clinical-outcome-in-st-elevation-myocardial-infarction-patients-the-circus-trial
#12
RANDOMIZED CONTROLLED TRIAL
Nathan Mewton, Thien T Cung, Olivier Morel, Guillaume Cayla, Eric Bonnefoy-Cudraz, Gilles Rioufol, Denis Angoulvant, Patrice Guerin, Meyer Elbaz, Nicolas Delarche, Pierre Coste, Gerald Vanzetto, Marc Metge, Jean-François Aupetit, Bernard Jouve, Pascal Motreff, Christophe Tron, Jean-Noël Labeque, Pierre G Steg, Yves Cottin, Grégoire Range, Jerome Clerc, Patrick Coussement, Fabrice Prunier, Frederique Moulin, Olivier Roth, Loic Belle, Phillipe Dubois, Paul Barragan, Martine Gilard, Christophe Piot, Patrice Colin, Marie-Claude Morice, Jean-Pierre Monassier, Omar Ider, Jean Luc P Dubois-Randé, Thierry Unterseeh, Hervé Lebreton, Thierry Beard, Didier Blanchard, Gilles Grollier, Vincent Malquarti, Patrick Staat, Arnaud Sudre, Magnus J Hansson, Eskil Elmer, Inesse Boussaha, Claire Jossan, Anna Torner, Marc Claeys, David Garcia-Dorado, Michel Ovize
BACKGROUND: Both acute myocardial ischemia and reperfusion contribute to cardiomyocyte death in ST-elevation myocardial infarction (STEMI). The final infarct size is the principal determinant of subsequent clinical outcome in STEMI patients. In a proof-of-concept phase II trial, the administration of cyclosporine prior to primary percutaneous coronary intervention (PPCI) has been associated with a reduction of infarct size in STEMI patients. METHODS: CIRCUS is an international, prospective, multicenter, randomized, double-blinded, placebo-controlled trial...
June 2015: American Heart Journal
https://www.readbyqxmd.com/read/25943557/kinetics-of-high-sensitivity-cardiac-troponin-t-and-i-differ-in-patients-with-st-segment-elevation-myocardial-infarction-treated-by-primary-coronary-intervention
#13
Guillaume Laugaudin, Nils Kuster, Amael Petiton, Florence Leclercq, Richard Gervasoni, Jean-Christophe Macia, Thien-Tri Cung, Anne-Marie Dupuy, Kamila Solecki, Benoit Lattuca, Stéphane Cade, Frédéric Cransac, Jean-Paul Cristol, François Roubille
PURPOSE: Cardiac biomarkers including troponins are the cornerstone of the biological definition of acute myocardial infarction. New high-sensitivity cardiac assays determining troponin T (hs-cTnT) as well as I ((hs-cTnI) from Abbott and s-cTnI from Siemens) raise concerns because of their unclear kinetics following the peak. AIMS: This study aims to compare kinetics of creatine kinases, hs-cTnT, hs-cTnI and s-cTnI in patients with ST-segment elevation myocardial infarction (STEMI) treated by percutaneous coronary intervention...
August 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/25890092/characterization-of-a-novel-endothelial-biosensor-assay-reveals-increased-cumulative-serum-inflammatory-potential-in-stabilized-coronary-artery-disease-patients
#14
Heidi Cung, Mario J Aragon, Katherine Zychowski, Joe R Anderson, James Nawarskas, Carlos Roldan, Akshay Sood, Clifford Qualls, Matthew J Campen
BACKGROUND: Vascular disease is promoted by systemic inflammation that can arise from sites distal to the affected vessels. We sought to characterize the net inflammatory potential of serum from patients with coronary artery disease (CAD) using cultured endothelial cells as a cumulative biosensor. METHODS AND RESULTS: Serum samples from CAD patients (N = 45) and healthy control subjects (N = 48) were incubated with primary human coronary artery endothelial cells at a 1:10 dilution for 4 h, followed by isolation of the cellular RNA...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/25525187/18f-fdg-pet-ct-monitoring-of-%C3%AE-3-agonist-stimulated-brown-adipocyte-recruitment-in-white-adipose-tissue
#15
Jin Won Park, Kyung-Ho Jung, Jin Hee Lee, Cung Hoa Thien Quach, Seung-Hwan Moon, Young Seok Cho, Kyung-Han Lee
UNLABELLED: There is rising interest in recruitment of brown adipocytes into white adipose tissue (WAT) as a means to augment energy expenditure for weight reduction. We thus investigated the potential of (18)F-FDG uptake as an imaging biomarker that can monitor the process of WAT browning. METHODS: C57BL/6 mice were treated daily with the β3 agonist CL316,243 (5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt), whereas controls received saline...
January 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/25445992/resveratrol-loaded-polymeric-nanoparticles-suppress-glucose-metabolism-and-tumor-growth-in-vitro-and-in-vivo
#16
Kyung-Ho Jung, Jin Hee Lee, Jin Won Park, Cung Hoa Thien Quach, Seung-Hwan Moon, Young Seok Cho, Kyung-Han Lee
Resveratrol (RSV) is a natural phenol with promising anti-tumor activities, but its use for in vivo cancer treatment is limited by low aqueous solubility and poor stability. In this study, we prepared RSV-loaded polyethylene glycol-polylactic acid (PEG-PLA; M.W. 5000-5000) polymer nanoparticles (NPs) for improved stability and controlled delivery, and investigated its metabolic and anti-tumor effect in vitro and in vivo. CT26 colon cancer cells displayed significantly reduced cell number to 5.6% and colony forming capacity to 6...
January 15, 2015: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/25381953/kinetics-of-high-sensitivity-cardiac-troponin-t-or-troponin-i-compared-to-creatine-kinase-in-patients-with-revascularized-acute-myocardial-infarction
#17
COMPARATIVE STUDY
Kamila Solecki, Anne Marie Dupuy, Nils Kuster, Florence Leclercq, Richard Gervasoni, Jean-Christophe Macia, Thien-Tri Cung, Benoit Lattuca, Frédéric Cransac, Stéphane Cade, Jean-Luc Pasquié, Jean-Paul Cristol, François Roubille
BACKGROUND: Cardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity cardiac troponin T (hs-cTnT) raises concerns because of its unclear kinetic following the peak. This study aims to compare kinetics of cTnI and hs-cTnT to CK in patients with large AMI successfully treated by percutaneous coronary intervention (PCI)...
April 2015: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/25214643/oxidized-low-density-lipoprotein-stimulates-macrophage-18f-fdg-uptake-via-hypoxia-inducible-factor-1%C3%AE-activation-through-nox2-dependent-reactive-oxygen-species-generation
#18
Su Jin Lee, Cung Hoa Thien Quach, Kyung-Ho Jung, Jin-Young Paik, Jin Hee Lee, Jin Won Park, Kyung-Han Lee
UNLABELLED: For (18)F-FDG PET to be widely used to monitor atherosclerosis progression and therapeutic response, it is crucial to better understand how macrophage glucose metabolism is influenced by the atherosclerotic microenvironment and to elucidate the molecular mechanisms of this response. Oxidized low-density lipoprotein (oxLDL) is a key player in atherosclerotic inflammation that promotes macrophage recruitment, activation, and foam cell formation. We thus explored the effect of oxLDL on macrophage (18)F-FDG uptake and investigated the underlying molecular mechanism including the roles of hypoxia-inducible factor-1α (HIF-1α) and reactive oxygen species (ROS)...
October 2014: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/25196827/stillbirths-at-a-hospital-in-nablus-2010-a-cohort-study
#19
Tam Giao Cung, Anne Sofie Paus, Ammar Aghbar, Torvid Kiserud, Sven Gudmund Hinderaker
BACKGROUND: Stillbirths are insufficiently reported in many countries. In Nablus, reporting has recently started; little is published in Palestine on the stillbirth rate and its risk factors. OBJECTIVE: To study the rate of stillbirths at Rafidia Hospital in 2010 and some of its risk factors. DESIGN: A retrospective cohort design. METHODS: Data were collected from the delivery registry for all births and we analysed those with a gestation of 28 weeks or more at Rafidia Hospital...
2014: Global Health Action
https://www.readbyqxmd.com/read/25111901/pulsed-transfer-etching-of-ps-pdms-block-copolymers-self-assembled-in-193-nm-lithography-stacks
#20
Cécile Girardot, Sophie Böhme, Sophie Archambault, Mathieu Salaün, Eddy Latu-Romain, Gilles Cunge, Olivier Joubert, Marc Zelsmann
This work presents the graphoepitaxy of high-χ block copolymers (BCP) in standard industry-like lithography stacks and their transfer into the silicon substrate The process includes conventional 193 nm photolithography, directed self-assembly of polystyrene-block-polydimethylsiloxane (PS-b-PDMS) and pulsed plasma etching to transfer the obtained features into the substrate. PS-b-PDMS has a high Flory-Huggins interaction parameter (high-χ) and is capable of achieving sub-10 nm feature sizes. The photolithography stack is fabricated on 300 mm diameter silicon wafers and is composed of three layers: spin-on-carbon (SoC), silicon-containing anti-reflective coating (SiARC) and 193 nm photolithography resist...
September 24, 2014: ACS Applied Materials & Interfaces
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