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https://www.readbyqxmd.com/read/29030915/political-transition-and-emergent-forest-conservation-issues-in-myanmar
#1
REVIEW
Graham W Prescott, William J Sutherland, Daniel Aguirre, Matthew Baird, Vicky Bowman, Jake Brunner, Grant M Connette, Martin Cosier, David Dapice, Jose Don T De Alban, Alex Diment, Julia Fogerite, Jefferson Fox, Win Hlaing, Saw Htun, Jack Hurd, Katherine LaJeunesse Connette, Felicia Lasmana, Cheng Ling Lim, Antony Lynam, Aye Chan Maung, Benjamin McCarron, John F McCarthy, William J McShea, Frank Momberg, Myat Su Mon, Than Myint, Robert Oberndorf, Thaung Naing Oo, Jacob Phelps, Madhu Rao, Dietrich Schmidt-Vogt, Hugh Speechly, Oliver Springate-Baginski, Robert Steinmetz, Kirk Talbott, Maung Maung Than, Tint Lwin Thaung, Salai Cung Lian Thawng, Kyaw Min Thein, Shwe Thein, Robert Tizard, Tony Whitten, Guy Williams, Trevor Wilson, Kevin Woods, Alan D Ziegler, Michal Zrust, Edward L Webb
Political and economic transitions have had substantial impacts on forest conservation. Where transitions are underway or anticipated, historical precedent and methods for systematically assessing future trends should be used to anticipate likely threats to forest conservation and design appropriate and prescient policy measures to counteract them. Myanmar is transitioning from an authoritarian, centralized state with a highly regulated economy to a more decentralized and economically liberal democracy and is working to end a long-running civil war...
October 14, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29028006/polymorphism-of-antibiotic-inactivating-enzyme-driven-by-ecology-expands-the-environmental-resistome
#2
Dae-Wi Kim, Cung Nawl Thawng, Jung-Hye Choi, Kihyun Lee, Chang-Jun Cha
The environmental resistome has been recognized as the origin and reservoir of antibiotic resistance genes and considered to be dynamic and ever expanding. In this study, a targeted gene sequencing approach revealed that the polymorphic diversity of the aminoglycoside-inactivating enzyme AAC(6')-Ib was ecological niche-specific. AAC(6')-Ib-cr, previously known as a clinical variant, was prevalent in various soils and the intestines of chickens and humans, suggesting that this variant might not have arisen from adaptive mutations in the clinic but instead originated from the environment...
October 13, 2017: ISME Journal
https://www.readbyqxmd.com/read/28949251/sialendoscopy-in-the-management-of-radioiodine-induced-sialadenitis-a-systematic-review
#3
REVIEW
Thai-Duong Cung, Wanda Lai, Peter F Svider, Curtis Hanba, Julie Samantray, Adam J Folbe, Mahdi Shkoukani, Syed Naweed Raza
OBJECTIVES: Salivary gland dysfunction as a consequence of radioiodide ablation is present in as many as two-thirds of patients, and unfortunately, many of these individuals do not respond to conservative measures. Sialendoscopy as a minimally invasive therapeutic modality may have utility in the treatment of radioiodide induced sialadenitis (RAIS). Our aim was to explore whether sialendoscopy resulted in clinical improvement in patients with RAIS. METHODS: A systematic review of studies on sialendoscopy for RAIS was conducted using MEDLINE database, Embase, and Cochrane Library...
November 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28647057/prevalence-of-obstructive-sleep-apnoea-in-acute-coronary-syndrome-routine-screening-in-intensive-coronary-care-units
#4
S Morra, F Bughin, K Solecki, M Aboubadra, B Lattuca, F Gouzi, J-C Macia, T-T Cung, S Cade, F Cransac, J-M Davy, Y Dauvilliers, D Corrado, F Roubille
INTRODUCTION: Increased evidence has shown that, despite the maximum care afforded to patients admitted with acute coronary syndromes (ACS), a residual risk of mortality remains, in which obstructive sleep apnoea (OSA) appears to be a largely undiagnosed factor, particularly in the intensive cardiac care unit (ICCU). The purpose of this study is to determine whether the systematic screening for sleep-disordered breathing (SDB) is feasible and may be recommended. The aims of our study are to determine: (1) The estimated prevalence of OSA in patients admitted to the ICCU for ACS determined by a validated, user-friendly portable screening device; (2) The feasibility of the screening in this context; (3) To assess any negative impact of OSA on the severity of ACS...
June 21, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28567445/unique-features-of-aeromonas-plasmid-pac3-and-expression-of-the-plasmid-mediated-quinolone-resistance-genes
#5
Dae-Wi Kim, Cung Nawl Thawng, Sang Hee Lee, Chang-Jun Cha
A highly fluoroquinolone-resistant isolate of Aeromonas species was isolated from a wastewater treatment plant and found to possess multiple resistance mechanisms, including mutations in gyrA and parC, efflux pumps, and plasmid-mediated quinolone resistance (PMQR) genes. Complete sequencing of the IncU-type plasmid, pAC3, present in the strain revealed a circular plasmid DNA 15,872 bp long containing two PMQR genes [qnrS2 and aac(6')-Ib-cr]. A mobile insertion cassette element containing the qnrS2 gene and a typical miniature inverted-repeat transposable element (MITE) structure was identified in the plasmid...
May 2017: MSphere
https://www.readbyqxmd.com/read/28344316/gain-in-the-short-arm-of-chromosome-2-2p-induces-gene-overexpression-and-drug-resistance-in-chronic-lymphocytic-leukemia-analysis-of-the-central-role-of-xpo1
#6
A Cosson, E Chapiro, N Bougacha, J Lambert, L Herbi, H-A Cung, C Algrin, B Keren, F Damm, C Gabillaud, M-N Brunelle-Navas, F Davi, H Merle-Béral, M Le Garff-Tavernier, D Roos-Weil, S Choquet, M Uzunov, V Morel, V Leblond, K Maloum, S Lepretre, P Feugier, C Lesty, J Lejeune, L Sutton, Y Landesman, S A Susin, F Nguyen-Khac
No abstract text is available yet for this article.
July 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28328565/control-of-walking-speed-in-children-with-cerebral-palsy
#7
Jon R Davids, Nina Q Cung, Suzy Chen, Mitell Sison-Williamson, Anita M Bagley
BACKGROUND: Children's ability to control the speed of gait is important for a wide range of activities. It is thought that the ability to increase the speed of gait for children with cerebral palsy (CP) is common. This study considered 3 hypotheses: (1) most ambulatory children with CP can increase gait speed, (2) the characteristics of free (self-selected) and fast walking are related to motor impairment level, and (3) the strategies used to increase gait speed are distinct among these levels...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28065445/colin-trial-value-of-colchicine-in-the-treatment-of-patients-with-acute-myocardial-infarction-and-inflammatory-response
#8
Mariama Akodad, Benoît Lattuca, Nicolas Nagot, Vera Georgescu, Mathilde Buisson, Jean-Paul Cristol, Florence Leclercq, Jean-Christophe Macia, Richard Gervasoni, Thien-Tri Cung, Stéphane Cade, Frédéric Cransac, Jessica Labour, Anne-Marie Dupuy, François Roubille
BACKGROUND: Inflammation is involved during acute myocardial infarction, and could be an interesting target to prevent ischaemia-reperfusion injuries. Colchicine, known for its pleiotropic anti-inflammatory effects, could decrease systemic inflammation in this context. AIMS: To evaluate the impact of colchicine on inflammation in patients admitted for ST-segment elevation myocardial infarction (STEMI). METHODS: All patients admitted for STEMI with one of the main coronary arteries occluded, and successfully treated with percutaneous coronary intervention, were included consecutively...
January 3, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28003032/commercial-sex-and-risk-of-hiv-syphilis-and-herpes-simplex-virus-2-among-men-who-have-sex-with-men-in-six-chinese-cities
#9
Cunge Zheng, Jun-Jie Xu, Qing-Hai Hu, Yan-Qiu Yu, Zhen-Xing Chu, Jing Zhang, Xiao-Xu Han, Lin Lu, Zhe Wang, Ji-Hua Fu, Xi Chen, Hong-Jing Yan, Yong-Jun Jiang, Wen-Qing Geng, Sten H Vermund, Han-Zhu Qian, Hong Shang
BACKGROUND: Men who have sex with men (MSM) are at high risk of HIV and sexually transmitted infections (STIs) in China and globally. Engaging in commercial sex put them at even greater risk. This study estimated the prevalence of HIV/STIs among three subgroups of MSM: MSM who sold sex (MSM-selling), MSM who bought sex (MSM-buying), and non-commercial MSM (NC-MSM) and evaluated the relationship between commercial sex and HIV/STIs. METHODS: We conducted a cross-sectional survey among MSM in six Chinese cities (Shenyang, Ji'nan, Changsha, Zhengzhou, Nanjing, and Kunming) from 2012 to 2013...
December 21, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27984186/immunolocalization-of-glutaryl-coa-dehydrogenase-gcdh-in-adult-and-embryonic-rat-brain-and-peripheral-tissues
#10
Olivier Braissant, Paris Jafari, Noémie Remacle, Hong-Phuc Cudré-Cung, Sonia Do Vale Pereira, Diana Ballhausen
Glutaryl-CoA dehydrogenase (GCDH) is a mitochondrial enzyme that is involved in the degradation of tryptophan, lysine and hydroxylysine. Deficient enzyme activity leads to glutaric aciduria type-I (GA-I). This neurometabolic disease usually manifests with acute encephalopathic crises and striatal neuronal death in early childhood leading to an irreversible dystonic-dyskinetic movement disorder. Fronto-temporal atrophy and white matter changes are already present in the pre-symptomatic period. No detailed information on GCDH expression during embryonic development and in adulthood was available so far...
October 27, 2016: Neuroscience
https://www.readbyqxmd.com/read/27599447/ammonium-accumulation-is-a-primary-effect-of-2-methylcitrate-exposure-in-an-in-vitro-model-for-brain-damage-in-methylmalonic-aciduria
#11
Hong-Phuc Cudré-Cung, Petra Zavadakova, Sónia do Vale-Pereira, Noémie Remacle, Hugues Henry, Julijana Ivanisevic, Denise Tavel, Olivier Braissant, Diana Ballhausen
Using 3D organotypic rat brain cell cultures in aggregates we recently identified 2-methylcitrate (2-MCA) as the main toxic metabolite for developing brain cells in methylmalonic aciduria. Exposure to 2-MCA triggered morphological changes and apoptosis of brain cells. This was accompanied by increased ammonium and decreased glutamine levels. However, the sequence and causal relationship between these phenomena remained unclear. To understand the sequence and time course of pathogenic events, we exposed 3D rat brain cell aggregates to different concentrations of 2-MCA (0...
September 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27479079/mild-alkalization-acutely-triggers-the-warburg-effect-by-enhancing-hexokinase-activity-via-voltage-dependent-anion-channel-binding
#12
Cung Hoa Thien Quach, Kyung-Ho Jung, Jin Hee Lee, Jin Won Park, Seung Hwan Moon, Young Seok Cho, Yearn Seong Choe, Kyung-Han Lee
To fully understand the glycolytic behavior of cancer cells, it is important to recognize how it is linked to pH dynamics. Here, we evaluated the acute effects of mild acidification and alkalization on cancer cell glucose uptake and glycolytic flux and investigated the role of hexokinase (HK). Cancer cells exposed to buffers with graded pH were measured for 18F-fluorodeoxyglucose (FDG) uptake, lactate production and HK activity. Subcellular localization of HK protein was assessed by western blots and confocal microscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27182706/exome-sequencing-identifies-a-novel-lmna-splice-site-mutation-and-multigenic-heterozygosity-of-potential-modifiers-in-a-family-with-sick-sinus-syndrome-dilated-cardiomyopathy-and-sudden-cardiac-death
#13
Michael V Zaragoza, Lianna Fung, Ember Jensen, Frances Oh, Katherine Cung, Linda A McCarthy, Christine K Tran, Van Hoang, Simin A Hakim, Anna Grosberg
The goals are to understand the primary genetic mechanisms that cause Sick Sinus Syndrome and to identify potential modifiers that may result in intrafamilial variability within a multigenerational family. The proband is a 63-year-old male with a family history of individuals (>10) with sinus node dysfunction, ventricular arrhythmia, cardiomyopathy, heart failure, and sudden death. We used exome sequencing of a single individual to identify a novel LMNA mutation and demonstrated the importance of Sanger validation and family studies when evaluating candidates...
2016: PloS One
https://www.readbyqxmd.com/read/27021851/is-there-a-difference-in-efficacy-safety-and-cost-effectiveness-between-3-factor-and-4-factor-prothrombin-complex-concentrates-among-trauma-patients-on-oral-anticoagulants
#14
COMPARATIVE STUDY
Alicia Mangram, Olakunle F Oguntodu, James K Dzandu, Alexzandra K Hollingworth, Scott Hall, Christina Cung, Jason Rodriguez, Igor Yusupov, Jeffrey F Barletta
PURPOSE: The aim of this study was to compare the efficacy, safety, and cost-effectiveness of 3-factor prothrombin complex concentrate (3F-PCC) vs 4-factor prothrombin complex concentrate PCC (4F-PCC) in trauma patients requiring reversal of oral anticoagulants. MATERIALS AND METHODS: All consecutive trauma patients with coagulopathy (international normalized ratio [INR] ≥1.5) secondary to oral anticoagulants who received either 3F-PCC or 4F-PCC from 2010 to 2014 at 2 trauma centers were reviewed...
June 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/26817755/outcomes-after-cryoablation-vs-radiofrequency-in-patients-with-paroxysmal-atrial-fibrillation-impact-of-pulmonary-veins-anatomy
#15
COMPARATIVE STUDY
Z Khoueiry, J-P Albenque, R Providencia, S Combes, N Combes, F Jourda, P A Sousa, C Cardin, J-L Pasquie, T T Cung, F Massin, E Marijon, S Boveda
AIMS: Pulmonary vein isolation is the mainstay of treatment in catheter ablation of paroxysmal atrial fibrillation (AF). Cryoballoon ablation has been introduced more recently than radiofrequency ablation, the standard technique in most centres. Pulmonary veins frequently display anatomical variants, which may compromise the results of cryoballoon ablation. We aimed to evaluate the mid-term outcomes of cryoballoon ablation in an unselected population with paroxysmal AF from an anatomical viewpoint...
September 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26654204/degradation-of-sec-hexylbenzene-and-its-metabolites-by-a-biofilm-forming-yeast-trichosporon-asahii-b1-isolated-from-oil-contaminated-sediments-in-quangninh-coastal-zone-vietnam
#16
Le Thi Nhi-Cong, Cung Thi Ngoc Mai, Nghiem Ngoc Minh, Hoang Phuong Ha, Do Thi Lien, Do Van Tuan, Dong Van Quyen, Michihiko Ike, Do Thi To Uyen
This article reports on the ability of yeast Trichosporon asahii B1 biofilm-associated cells, compared with that of planktonic cells, to transform sec-hexylbenzene and its metabolites. This B1 strain was isolated from a petroleum-polluted sediment collected in the QuangNinh coastal zones in Vietnam, and it can transform the branched aromatic hydrocarbons into a type of forming biofilm (pellicle) more efficiency than that the planktonic forms can. In the biofilm cultivation, seven metabolites, including acetophenone, benzoic acid, 2,3-dihydroxybenzoic acid, β-methylcinnamic acid, 2-phenylpropionic acid, 3-phenylbutyric acid, and 5-phenylhexanoic acid were extracted by ethyl acetate and analyzed by HPLC and GC-MS...
2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/26449833/troglitazone-stimulates-cancer-cell-uptake-of-18f-fdg-by-suppressing-mitochondrial-respiration-and-augments-sensitivity-to-glucose-restriction
#17
Seung-Hwan Moon, Su Jin Lee, Kyung-Ho Jung, Cung Hoa Thien Quach, Jin-Won Park, Jin Hee Lee, Young Seok Cho, Kyung-Han Lee
UNLABELLED: We evaluated how troglitazone influences cancer cell glucose metabolism and uptake of (18)F-FDG, and we investigated its molecular mechanism and relation to the drug's anticancer effect. METHODS: Human T47D breast and HCT116 colon cancer cells that had been treated with troglitazone were measured for (18)F-FDG uptake, lactate release, oxygen consumption rate, mitochondrial membrane potential, and intracellular reactive oxygen species. Viable cell content was measured by sulforhodamine-B assays...
January 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26360873/cephalometry-in-adults-and-children-with-neurofibromatosis-type-1-implications-for-the-pathogenesis-of-sphenoid-wing-dysplasia-and-the-nf1-facies
#18
Winnie Cung, Laura A Freedman, Nicholas E Khan, Elaine Romberg, Pamela J Gardner, Carol W Bassim, Andrea M Baldwin, Brigitte C Widemann, Douglas R Stewart
BACKGROUND: Neurofibromatosis type 1 (NF1) is a common, autosomal dominant tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1. Cephalometry is an inexpensive, readily available and non-invasive technique that is under-utilized in studying the NF1 craniofacial phenotype. An analysis of NF1 cephalometry was first published by Heervä et al. in 2011. We expand here on that first investigation with a larger cohort of adult and pediatric patients affected with NF1 and sought objective insight into the NF1 facies, said to feature hypertelorism and a broad nasal base, from cephalometric analysis...
November 2015: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/26338893/spect-myocardial-perfusion-reserve-in-patients-with-multivessel-coronary-disease-correlation-with-angiographic-findings-and-invasive-fractional-flow-reserve-measurements
#19
Fayçal Ben Bouallègue, François Roubille, Benoit Lattuca, Thien Tri Cung, Jean-Christophe Macia, Richard Gervasoni, Florence Leclercq, Denis Mariano-Goulart
UNLABELLED: Quantification of myocardial perfusion reserve (MPR) is an emerging topic in nuclear cardiology with an expected diagnostic and prognostic incremental value, especially for patients with severe coronary artery disease. The advent of new dedicated solid-state cameras has opened new perspectives for perfusion quantitation in SPECT. We appraised the feasibility of perfusion reserve estimation using a cadmium zinc telluride camera in a cohort of multivessel patients and its pertinence with respect to angiographic data...
November 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26321103/cyclosporine-before-pci-in-patients-with-acute-myocardial-infarction
#20
RANDOMIZED CONTROLLED TRIAL
Thien-Tri Cung, Olivier Morel, Guillaume Cayla, Gilles Rioufol, David Garcia-Dorado, Denis Angoulvant, Eric Bonnefoy-Cudraz, Patrice Guérin, Meier Elbaz, Nicolas Delarche, Pierre Coste, Gerald Vanzetto, Marc Metge, Jean-François Aupetit, Bernard Jouve, Pascal Motreff, Christophe Tron, Jean-Noel Labeque, Philippe Gabriel Steg, Yves Cottin, Grégoire Range, Jérome Clerc, Marc J Claeys, Patrick Coussement, Fabrice Prunier, Frédéric Moulin, Olivier Roth, Loïc Belle, Philippe Dubois, Paul Barragan, Martine Gilard, Christophe Piot, Patrice Colin, Fabien De Poli, Marie-Claude Morice, Omar Ider, Jean-Luc Dubois-Randé, Thierry Unterseeh, Hervé Le Breton, Thierry Béard, Didier Blanchard, Gilles Grollier, Vincent Malquarti, Patrick Staat, Arnaud Sudre, Eskil Elmer, Magnus J Hansson, Cyrille Bergerot, Inesse Boussaha, Claire Jossan, Geneviève Derumeaux, Nathan Mewton, Michel Ovize
BACKGROUND: Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling. METHODS: In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation myocardial infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset and who had complete occlusion of the culprit coronary artery to receive a bolus injection of cyclosporine (administered intravenously at a dose of 2...
September 10, 2015: New England Journal of Medicine
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