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https://www.readbyqxmd.com/read/27915346/mir-181a-targets-phlpp2-to-augment-akt-signaling-and-regulate-proliferation-and-apoptosis-in-human-keloid-fibroblasts
#1
Zhen Rang, Zong-Yang Wang, Qiu-Yu Pang, You-Wei Wang, Ge Yang, Fan Cui
BACKGROUND/AIMS: Keloids are fibrous overgrowths induced by cutaneous injury. MicroRNAs (miRNAs) have recently emerged as post-transcriptional gene repressors and participants in a diverse array of pathophysiological processes leading to skin disease. The purpose of the current study was to explore the precise functions of miR-181a in human keloid development and the underlying mechanisms. METHODS: A miRNA microarray analysis was performed to compare expression profiles between keloid and normal skin tissues...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915285/depth-dependent-influence-of-different-land-use-systems-on-bacterial-biogeography
#2
Brent J Seuradge, Maren Oelbermann, Josh D Neufeld
Despite progress in understanding microbial biogeography of surface soils, few studies have investigated depth-dependent distributions of terrestrial microorganisms in subsoils. We leveraged high-throughput sequencing of 16S rRNA genes obtained from soils collected from the RARE: Charitable Research Reserve (Cambridge, Ontario, Canada) to assess the influence of depth on bacterial communities across various land-use types. Although bacterial communities were strongly influenced by depth across all sites, the magnitude of this influence was variable and demonstrated that land-use attributes also played a significant role in shaping soil bacterial communities...
December 2, 2016: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27914077/making-fluorescent-streptococci-and-enterococci-for-live-imaging
#3
Sarah Shabayek, Barbara Spellerberg
Since the discovery of the green fluorescent protein (GFP) from the jellyfish Aequorea victoria, outstanding fluorescent labeling tools with numerous applications in vastly different areas of life sciences have been developed. To optimize GFP for diverse life science applications, a large variety of GFP derivatives with different environmental characteristics have been generated by mutagenesis. The enhanced green fluorescent protein (EGFP) is a well-known GFP derivative with highly increased fluorescence intensity compared to the GFP wild-type molecule...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913529/ph-like-acute-lymphoblastic-leukemia
#4
Thai Hoa Tran, Mignon L Loh
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a newly identified high-risk (HR) B-lineage ALL subtype, accounting for ∼15% of children with National Cancer Institute-defined HR B-ALL. It occurs more frequently in adolescents and adults, having been reported in as much as 27% of young adults with ALL between 21 and 39 years of age. It exhibits adverse clinical features, confers a poor prognosis, and harbors a diverse range of genetic alterations that activate cytokine receptor genes and kinase signaling pathways, making it amenable to treatment with tyrosine kinase inhibitor (TKI) therapy...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27912188/bacillus-flexus-strain-as-12-a-new-arsenic-transformer-bacterium-isolated-from-contaminated-water-resources
#5
Mohammad Ahmadi Jebeli, Afshin Maleki, Mohammad Ali Amoozegar, Enayatollah Kalantar, Hassan Izanloo, Fardin Gharibi
A total of 14 arsenic-resistant bacteria were isolated from an arsenic-contaminated travertine spring water in the central district of Qorveh county, Kurdistan Province, Iran. One of strains designated As-12 was selected for further investigation because of its ability to transform arsenic. The strain was identified by cultural, morphological and biochemical tests, and 16S rRNA gene sequencing. Finally, the growth characteristics of the isolate were investigated in a chemically defined medium which included varied ranges of environmental factors such as pH, temperature and salinity...
November 29, 2016: Chemosphere
https://www.readbyqxmd.com/read/27911258/clostridium-guangxiense-sp-nov-and-clostridium-neuense-sp-nov-two-phylogenetically-closely-related-hydrogen-producing-species-isolated-from-lake-sediment
#6
Xin Zhao, Danyang Li, Shuhong Xu, Zhanghao Guo, Yan Zhang, Lin Man, Binhui Jiang, Xiaomin Hu
Two novel anaerobic, mesophilic, bio-hydrogen producing bacteria, designated strains ZGM211T and G1T, were isolated from lake sediment. 16S rRNA and ATP synthase beta subunit (atpD) gene sequences phylogenetic analysis of strains ZGM211T and G1T revealed an affiliation to the genus Clostridium sensu stricto (cluster I of the clostridia), with Clostridium acetobutylicum as the closest characterized species, showing the same sequence similarity of 96.4% to the type strain (98.9% between the two isolates). Cells of the two strains were rod-shaped...
December 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27911255/euzebyella-marina-sp-nov-isolated-from-seawater
#7
Yan-Jiao Zhang, Jia-Rui Zhao, Xi-Ying Zhang, Guo-Zhong Chen, Ming-Yang Zhou, Xu-Hua Mo, Hai-Lun He, Shiyong Chen
A Gram-negative, aerobic, yellow-pigmented, non-flagellated, non-gliding, oxidase- and catalase- positive bacterium, designated CY01T, was isolated from seawater of the Yellow Sea. Strain CY01T grew at 15-37 C (optimum, 30 C), at pH 5-8 (optimum, 6.5-7.5) and with 0.5-12 % (w/v) NaCl (optimum, 0.5-3.5 %). It could not produce flexirubin-type pigment or reduce nitrate to nitrite. Strain CY01T showed the highest 16S rRNA gene sequence similarity to type strain of Euzebyella saccharophila (97.0 %) and clustered tightly with the Euzebyella species in the phylogenetic trees based on the 16S rRNA gene sequences...
December 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27911253/luteolibacter-flavescens-sp-nov-isolated-from-deep-seawater
#8
Chongya Zhang, Bolin Dong, Ruijun Wang, Yue Su, Shuaibo Han, Xiaoyun Yu, Zhe Zhao, Geyi Fu, Cong Sun, Min Wu
A novel Gram-stain-negative, rod-shaped, non-motile strain, designated GKXT, was isolated from deep seawater. Strain GKXT was able to grow at 20-35 °C (optimum, 25 °C), pH 5.5-9.5 (optimum, 7.5) and 0-4.0 % (w/v) NaCl (optimum, 1.0 %). The major fatty acids were C16:1 ω9c (15.4 %), C16:0 (18.4 %), C14:0 (12.0 %), iso-C14:0 (30.1 %) and anteiso-C15:0 (5.7 %). Strain GKXT contained phosphatidylethanolamine (PE), phosphatidylmethylethanoamine (PME), phosphatidylglycerol (PG), diphosphatidylglycerol (DPG) and one unidentified glycolipid (GL) as the main polar lipids...
December 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27910771/induction-of-flavin-containing-monooxygenase-in-mice-by-oral-administration-of-phellinus-baumii-agaricomycetes-extract
#9
Batbayar Sainkhuu, Beom Su Park, Ha Won Kim
Phellinus baumii is a yellow mushroom long used in alternative medicine in Korea and other central Asian countries. To identify genes affected by a single or 7-day oral administration of a water extract of Ph. Baumii, mouse liver tissue was analyzed using microarrays. The results showed that 8 and 23 genes were upregulated and 3 and 11 genes downregulated more than 3-fold by single and multiple oral administrations of 100 mg/kg PBE, respectively. Among the upregulated genes, the expression of 3 flavin-containing monooxygenase (Fmo) family genes, Fmo2-4, was upregulated in a concentration-dependent manner...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910061/inhaled-gene-transfer-for-pulmonary-circulation
#10
Jaume Aguero, Lahouaria Hadri, Nadjib Hammoudi, Lauren Leonardson, Roger J Hajjar, Kiyotake Ishikawa
Chronic pulmonary hypertension (PH) is associated with right ventricular failure and high mortality regardless of the underlying disease. Currently, therapies can improve clinical outcomes in specific subsets of patients, but have little impact on the progression of pulmonary vascular remodeling. Upon new advances in vector development and delivery techniques, gene therapy is a novel strategy in this field with the potential of overcoming the main limitations of approved drug therapies: modulation of novel anti-remodeling targets and selective pulmonary vasculature targeting with minimal systemic effects...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27909912/identification-and-characterization-of-the-lysine-rich-matrix-protein-family-in-pinctada-fucata-indicative-of-roles-in-shell-formation
#11
Jian Liang, Jun Xie, Jing Gao, Chao-Qun Xu, Yi Yan, Gan-Chu Jia, Liang Xiang, Li-Ping Xie, Rong-Qing Zhang
Mantle can secret matrix proteins playing key roles in regulating the process of shell formation. The genes encoding lysine-rich matrix proteins (KRMPs) are one of the most highly expressed matrix genes in pearl oysters. However, the expression pattern of KRMPs is limited and the functions of them still remain unknown. In this study, we isolated and identified six new members of lysine-rich matrix proteins, rich in lysine, glycine and tyrosine, and all of them are basic matrix proteins. Combined with four members of the KRMPs previously reported, all these proteins can be divided into three subclasses according to the results of phylogenetic analyses: KRMP1-3 belong to subclass KPI, KRMP4-5 belong to KPII, and KRMP6-10 belong to KPIII...
December 2, 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27909815/homoeologous-recombination-in-the-presence-of-ph1-gene-in-wheat
#12
Dal-Hoe Koo, Wenxuan Liu, Bernd Friebe, Bikram S Gill
A crossover (CO) and its cytological signature, the chiasma, are major features of eukaryotic meiosis. The formation of at least one CO/chiasma between homologous chromosome pairs is essential for accurate chromosome segregation at the first meiotic division and genetic recombination. Polyploid organisms with multiple sets of homoeologous chromosomes have evolved additional mechanisms for the regulation of CO/chiasma. In hexaploid wheat (2n = 6× = 42), this is accomplished by pairing homoeologous (Ph) genes, with Ph1 having the strongest effect on suppressing homoeologous recombination and homoeologous COs...
December 1, 2016: Chromosoma
https://www.readbyqxmd.com/read/27909431/the-microbiota-of-recreational-freshwaters-and-the-implications-for-environmental-and-public-health
#13
Chang Soo Lee, Minseok Kim, Cheonghoon Lee, Zhongtang Yu, Jiyoung Lee
The microbial communities in recreational freshwaters play important roles in both environmental and public health perspectives. In this study, the bacterial community structure and its associations with freshwater environments were investigated by analyzing the summertime microbiomes of three beach waters in Ohio (East Fork, Delaware, and Madison lakes) together with environmental and microbial water quality parameters. From the swimming season of 2009, 21 water samples were collected from the three freshwater beaches...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27908241/molecular-cloning-biochemical-characterization-and-antitumor-properties-of-a-novel-l-asparaginase-from-synechococcus-elongatus-pcc6803
#14
R Kebeish, A El-Sayed, H Fahmy, A Abdel-Ghany
L-asparaginase (EC 3.5.1.1), which catalyzes the deamidation of L-asparagine to L-aspartic acid and ammonia, has been widely used as a key therapeutic tool in the treatment of tumors. The current commercially available L-asparaginases, produced from bacteria, have signs of toxicity and hypersensitivity reactions during the course of tumor therapy. Therefore, searching for L-asparaginases with unique biochemical properties and fewer adverse effects was the objective of this work. In this study, cyanobacterial strain Synechococcus elongatus PCC6803 was found as a novel source of L-asparaginase...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27907152/dietary-probiotic-bacillus-subtilis-strain-fmbj-increases-antioxidant-capacity-and-oxidative-stability-of-chicken-breast-meat-during-storage
#15
Wen Kai Bai, Fei Jing Zhang, Tian Jin He, Peng Wei Su, Xiong Zhi Ying, Li Li Zhang, Tian Wang
This study was aimed to measure the dietary effects of probiotic Bacillus subtilis strain fmbj (BS fmbj) on antioxidant capacity and oxidative stability of chicken breast meat during storage. Treatment groups were fed the basal diet with BS fmbj at 0 g/kg (CON), 0.2 g/kg (BS-1), 0.3 g/kg (BS-2), or 0.4 g/kg (BS-3) doses without antibiotics. During 8 days of storage at 4°C, BS-2 group showed a significant improvement (P < 0.05) on meat quality (pH, Drip loss, Cooking loss, Shear force, color L*, a*, b*), free radical scavenging activity (DPPH, ABTS+, H2O2), tissues antioxidant enzyme capacity (SOD, CAT, GSH-Px, GSH, T-SH), mitochondria antioxidant enzyme capacity (MnSOD, GPx, GSH), mRNA expression of antioxidant genes (Nrf2, HO-1, SOD, CAT, GSH-Px) and mitochondrial function genes (avUCP, NRF1, NRF2, TFAM, PGC-1α), oxidative damage index (MDA, ROS, PC, 8-OHdG), and MMP level in chicken breast meat as compared to the CON group...
2016: PloS One
https://www.readbyqxmd.com/read/27906384/cationic-switchable-lipids-ph-triggered-molecular-switch-for-sirna-delivery
#16
W Viricel, S Poirier, A Mbarek, R M Derbali, G Mayer, J Leblond
A pH-sensitive molecular switch able to change its conformation upon protonation at endosomal pH values is embedded into the structure of cationic lipidoid materials, thus conferring endosomal escape properties. Involvement of the conformational switch in the endosomal escape process was confirmed and leading material identified was able to induce efficient gene knockdown both in vitro and in vivo. The lipid nanoparticles reported here are promising for therapeutic applications and this work could serve as a template for future design of stimulus-responsive (ionic, redox, light) molecular switch for drug and gene delivery...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27902348/micropepsis-pineolensis-gen-nov-sp-nov-a-mildly-acidophilic-alphaproteobacterium-isolated-from-a-poor-fen-and-proposal-of-micropepsaceae-fam-nov-within-micropepsales-ord-nov
#17
Austin B Harbison, Laiken E Price, Michael D Flythe, Suzanna L Brauer
An obligately anaerobic, mildly acidophilic, fermentative alphaproteobacterium, designated strain CS4 T, was isolated from an acidic, oligotrophic (nutrient-poor) poor fen located near Pineola, NC, USA. Cultures contained Gram-negative staining, slightly curved, non-motile, non-spore forming, non-prosthecate rods (0.1-0.4 µm in diameter and 0.4-4 µm long, depending, in part, on the growth substrate). Growth optima were 35° C (range 15 - 35°C), pH 5.6 (range of 5.0 - 6.8), and with 0-50 mM added NaCl (range 0-100 mM added NaCl)...
November 21, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902346/hymenobacter-rutilus-sp-nov-isolated-from-marine-sediment-in-arctic
#18
Myong Chol Kim, Chol Myong Kim, Ok Chol Kang, Yumin Zhang, Zuobing Liu, Danzeng Wangmu, Ziyan Wei, Yao Huang, Fang Peng
Strain K2-33028T, appeared brick-red colony on R2A plate, was isolated from marine sediment sample in Kings Bay, Svalbard Archipelago, Norway. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain K2-33028T belonged to the genus Hymenobacter. Cells were Gram-reaction-negative, non-spore-forming, aerobic, rod-shaped bacterium without motility. Growth occurred at 4-37℃ (optimum 28℃) and at pH 6.0-8.0 (optimum pH 7.0). Cells contained menaquinone-7, as the main respiratory quinone, and iso-C15:0, summed feature 3 (comprising C16:1 ω7c and/or C16:1 ω6c), C16:1 ω5c, summed feature 4 (comprising anteiso-C17:1 B and/or iso-C17:1 I) and anteiso-C15:0 as the major cellular fatty acids...
November 21, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902337/thermodesulfitimonas-autotrophica-gen-nov-sp-nov-a-thermophilic-obligate-sulfite-reducing-bacterium-isolated-from-a-terrestrial-hot-spring
#19
G B Slobodkina, R V Baslerov, A A Novikov, E A Bonch-Osmolovskaya, A I Slobodkin
A novel thermophilic, anaerobic, chemolithoautotrophic bacterium, strain SF97T, was isolated from a terrestrial hot spring (Kuril Islands, Russia). Cells of strain SF97T were rod-shaped and motile with a Gram-positive cell-wall type. The novel isolate grew at 45-72oC (optimum 65oC) and pH 5.5-8.5 (optimum 6.0-6.5). The strain grew chemolithoautotrophically with molecular hydrogen as electron donor, sodium sulfite or SO2 gas as electron acceptor and bicarbonate/CO2 as a carbon source. Sulfate, thiosulfate, elemental sulfur, Fe(III) or nitrate were not used as an electron acceptors either with H2 or organic electron donors...
October 27, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902335/defluviitalea-raffinosedens-sp-nov-a-novel-thermophilic-anaerobic-saccharolytic-bacterium-isolated-from-an-anaerobic-batch-digester-treating-animal-manure-and-rice-straw
#20
Shichun Ma, Yan Huang, Cong Wang, Hui Fan, Lirong Dai, Zheng Zhou, Xing Liu, Yu Deng
A thermophilic, anaerobic, fermentative bacterium, strain A6T, was obtained from an anaerobic batch digester treating animal manure and rice straw. The strain was Gram-positive, slightly curved rods with a size of 0.6-1 μm × 2.5-8.2 μm, non-motile, and produced terminal spores. The temperature, pH, and NaCl concentration ranges for growth were 40°C-60°C, 6.5-8.0, and 0-15.0 g/L, with optimum growth noted at 50°C-55°C, pH 7.5, and in the absence of NaCl, respectively. Yeast extract was required for growth...
November 14, 2016: International Journal of Systematic and Evolutionary Microbiology
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