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https://www.readbyqxmd.com/read/28330282/in-vitro-cytotoxicity-and-antibacterial-activity-of-silver-coated-electrospun-polycaprolactone-gelatine-nanofibrous-scaffolds
#1
Mim Mim Lim, Naznin Sultana
The development of nano-sized scaffolds with antibacterial properties that mimic the architecture of tissue is one of the challenges in tissue engineering. In this study, polycaprolactone (PCL) and PCL/gelatine (Ge) (70:30) nanofibrous scaffolds were fabricated using a less toxic and common solvent, formic acid and an electrospinning technique. Nanofibrous scaffolds were coated with silver (Ag) in different concentrations of silver nitrate (AgNO3) aqueous solution (1.25, 2.5, 5, and 10 %) by using dipping method, drying and followed by ultraviolet (UV) photoreduction...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327272/effects-of-electrospun-scaffolds-of-di-o-butyrylchitin-and-poly-%C3%AE%C2%B5-caprolactone-on-wound-healing
#2
Jacek Drobnik, Izabella Krucinska, Agnieszka Komisarczyk, Stanislaw Sporny, Alicja Szczepanowska, Joanna Ciosek
BACKGROUND: We sought to determine the usefulness of electrospun dibutyrylchitin (DBC) or poly (ε-Caprolactone [PCL]), in wound treatment. We investigated the mechanisms of action of these polymers on wound healing. METHODS: We synthesized DBC, a newly identified ester derivative of chitin, using a patented method comprising the substitution of butyryl groups at positions C-3 and C-6 in chitin molecules. We confirmed the double substitution by the butyric groups using infrared spectrometry...
April 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28326322/a-comparison-of-tissue-engineering-scaffolds-incorporated-with-manuka-honey-of-varying-umf
#3
Katherine R Hixon, Tracy Lu, Sarah H McBride-Gagyi, Blythe E Janowiak, Scott A Sell
Purpose. Manuka honey (MH) is an antibacterial agent specific to the islands of New Zealand containing both hydrogen peroxide and a Unique Manuka Factor (UMF). Although the antibacterial properties of MH have been studied, the effect of varying UMF of MH incorporated into tissue engineered scaffolds have not. Therefore, this study was designed to compare silk fibroin cryogels and electrospun scaffolds incorporated with a 5% MH concentration of various UMF. Methods. Characteristics such as porosity, bacterial clearance and adhesion, and cytotoxicity were compared...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28324629/electrospun-nerve-guide-scaffold-of-poly-%C3%AE%C2%B5-caprolactone-collagen-nano-bioglass-an-in-vitro-study-in-peripheral-nerve-tissue-engineering
#4
Forouzan Mohamadi, Somayeh Ebrahimi-Barough, Mohammad Reza Nourani, Mohammad Ali Derakhshan, Vahabodin Goodarzi, Mohammad Sadegh Nazockdast, Mehdi Farokhi, Roksana Tajerian, Reza Faridi Majidi, Jafar Ai
In among of various methods, nerve tissue engineering (NTE) is one of the applicable methods to reconstruct damaged nerve tissues. Electrospinning technique and biomaterials are often considered to fabricate fibrous tissue engineered conduits which have great similarity to the extracellular matrix on fiber structure. Polymer blending is one of the most effective methods for production of new materials with outstanding features. In this research, conduit structures as main part of the peripheral nerve regeneration based on polymer blend nanocomposites PCL/Collagen/NBG (poly (ε-caprolactone)/Collagen/nano bioglass) were manufactured by electrospinning technique...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28322042/differentiation-of-bone-marrow-stem-cells-into-schwann-cells-for-the-promotion-of-neurite-outgrowth-on-electrospun-fibers
#5
Jiajia Xue, Junyu Yang, Deirdre Margaret O'Connor, Chunlei Zhu, Da Huo, Nicholas M Boulis, Younan Xia
Seeding nerve guidance conduits with Schwann cells can improve the outcome of peripheral nerve injury repair. Bone marrow stem cells (BMSCs) represent a good choice of the cell source as they can differentiate into Schwann cells under appropriate conditions. In this work, we systematically investigated the differentiation of BMSCs into Schwann cells on scaffolds comprised of electrospun fibers. We changed the alignment, diameter, and surface properties of the fibers to optimize the differentiation efficiency...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28320528/superfine-powdered-activated-carbon-incorporated-into-electrospun-polystyrene-fibers-preserve-adsorption-capacity
#6
Onur G Apul, Natalia Hoogesteijn von Reitzenstein, Jared Schoepf, David Ladner, Kiril D Hristovski, Paul Westerhoff
A composite material consisted of superfine powdered activated carbon (SPAC) and fibrous polystyrene (PS) was fabricated for the first time by electrospinning. SPAC is produced by pulverizing powdered activated carbon. The diameter of SPAC (100-400nm) is more than one hundred times smaller than conventional powdered activated carbon, but it maintains the internal pore structure based on organic micropollutant adsorption isotherms and specific surface area measurements. Co-spinning SPAC into PS fibers increased specific surface area from 6m(2)/g to 43m(2)/g...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319219/interface-defect-tuneable-macro-and-micro-photoluminescence-behaviours-of-trivalent-europium-ions-in-electrospun-zro2-zno-porous-nanobelts
#7
Yanzhe Mao, Jinglong Bai, Mingxiang Zhang, Hao Zhao, Gengzhi Sun, Xiaojun Pan, Zhenxing Zhang, Jinyuan Zhou, Erqing Xie
It was demonstrated that suitable interfaces between two materials can enhance the separation of photogenerated carriers. In this study, ZrO2/ZnO interfaces with type I structure were designed and prepared by the electrospinning technique. The obtained ZrO2/ZnO:Eu(3+) (ZZOE) composites are highly porous in the form of nanobelts with width of 600-700 nm, comprising ZnO and ZrO2 nanocrystals, and the Eu doping can hinder the t-m phase transition of ZrO2. By tuning the annealing temperature, the inner stress and defects can be well controlled to improve the photoluminescence (PL) of the ZZOE porous nanobelts...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28318155/-biomineralization-of-electrospun-polycaprolactone-guided-bone-regeneration-membrane
#8
Deng Xia, Bai Shi
OBJECTIVE: To evaluate the biomineralization of the tissue-engineering electrospun polycaprolactone (PCL) scaffold and its potential use for guided bone regeneration (GBR) membranes. METHODS: PCL ultrafinefiber scaffolds were fabricated by electrospinning and then immersed in supersaturated calcification solution (SCS) for biomineralization investigation. The electrospun PCL scaffolds and the calcium phosphate coating were identified by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR)...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28306194/electrospun-biodegradable-microfibers-induce-new-collagen-formation-in-a-rat-abdominal-wall-defect-model-a-possible-treatment-for-pelvic-floor-repair
#9
Cecilie Glindtvad, Menglin Chen, Jens Vinge Nygaard, Lise Wogensen, Axel Forman, Carl Christian Danielsen, Mehmet Berat Taskin, Karl-Erik Andersson, Susanne Maigaard Axelsen
Half of the female population over age 50 years will experience pelvic organ prolapse. We suggest a new approach based on tissue engineering principles to functionally reconstruct the anatomical structures of the pelvic floor. The aim of this study is to investigate the mechanical performance and effect on collagen and elastin production of a degradable mesh releasing basic fibroblast growth factor (bFGF). Implantation of biodegradable mesh with or without bFGF in their core has been conducted in 40 rats in an abdominal wall defect model...
March 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28303522/nanotechnology-for-the-treatment-of-melanoma-skin-cancer
#10
REVIEW
Lucas B Naves, Chetna Dhand, Jayarama Reddy Venugopal, Lakshminarayanan Rajamani, Seeram Ramakrishna, Luis Almeida
Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. This literature review intends to elucidate the possibilities to treat melanoma skin cancer using hybrid nanofibers developed by advanced electrospinning process. In this review we have shown that the enhanced permeability and retention is the basis for using nanotechnology, aiming topical drug delivery. The importance of the detection of skin cancer in the early stages is directly related to non-metastatic effects and survival rates of melanoma cells...
March 16, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28301130/graphene-embedded-hydrogel-nanofibers-for-detection-and-removal-of-aqueous-phase-dyes
#11
Kyungun Im, Duong Nguyen Nguyen, Saerona Kim, Hye Jeong Kong, Yukyung Kim, Chul Soon Park, Oh Seok Kwon, Hyeonseok Yoon
A facile route to graphene/polymer hydrogel nanofibers was developed. An aqueous dispersion of graphene (containing >40% bilayer graphene flakes) stabilized by a functionalized water-soluble polymer with phenyl side chains was successfully electrospun to yield nanofibers. Subsequent vapor-phase cross-linking of the nanofibers produced graphene-embedded hydrogel nanofibers (GHNFs). Interestingly, the GHNFs showed chemical sensitivity to the cationic dyes methylene blue (MB) and crystal violet (CV) in the aqueous phase...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28299922/fabrication-of-electrospun-mucoadhesive-membranes-for-therapeutic-applications-in-oral-medicine
#12
Martin E Santocildes-Romero, Lucie Hadley, Katharina H Clitherow, Jens Hansen, Craig Murdoch, Helen E Colley, Martin Thornhill, Paul V Hatton
Oral mucosal lesions are related to several etiologies including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes or gels containing suitable drugs. However, topical medications may be relatively ineffective as they are removed rapidly from oral surfaces, limiting drug contact times. Systemic medications might be more effective, but are associated with unacceptable off-target side effects...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28295875/enhancing-the-mechanical-properties-of-electrospun-nanofiber-mats-through-controllable-welding-at-the-cross-points
#13
Haoxuan Li, Chunlei Zhu, Jiajia Xue, Qinfei Ke, Younan Xia
This communication describes a simple and effective method for welding electrospun nanofibers at the cross points to enhance the mechanical properties of their nonwoven mats. The welding is achieved by placing a nonwoven mat of the nanofibers in a capped vial with the vapor of a proper solvent. For polycaprolactone (PCL) nanofibers, the solvent is dichloromethane (DCM). The welding can be managed in a controllable fashion by simply varying the partial pressure of DCM and/or the exposure time. Relative to the pristine nanofiber mat, the mechanical strength of the welded PCL nanofiber mat can be increased by as much as 200%...
March 10, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28294237/surface-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-of-small-drug-molecules-and-high-molecular-weight-synthetic-biological-polymers-using-electrospun-composite-nanofibers
#14
Juan Bian, Susan V Olesik
Polyacrylonitrile/Nafion®/carbon nanotube (PAN/Nafion®/CNT) composite nanofibers were prepared using electrospinning. These electrospun nanofibers were studied as possible substrates for surface-assisted laser desorption/ionization (SALDI) and matrix-enhanced surface-assisted laser desorption/ionization time-of-flight mass spectrometry (ME-SALDI/TOF-MS) for the first time in this paper. Electrospinning provides this novel substrate with a uniform morphology and a narrow size distribution, where CNTs were evenly and firmly immobilized on polymeric nanofibers...
March 15, 2017: Analyst
https://www.readbyqxmd.com/read/28290503/electrospun-nb-doped-tio2-nanofiber-support-for-pt-nanoparticles-with-high-electrocatalytic-activity-and-durability
#15
MinJoong Kim, ChoRong Kwon, KwangSup Eom, JiHyun Kim, EunAe Cho
This study explores a facile method to prepare an efficient and durable support for Pt catalyst of polymer electrolyte membrane fuel cell (PEMFC). As a candidate, Nb-doped TiO2 (Nb-TiO2) nanofibers are simply fabricated using an electrospinning technique, followed by a heat treatment. Doping Nb into the TiO2 nanofibers leads to a drastic increase in electrical conductivity with doping level of up to 25 at. % (Nb0.25Ti0.75O2). Pt nanoparticles are synthesized on the prepared 25 at. % Nb-doped TiO2-nanofibers (Pt/Nb-TiO2) as well as on a commercial powdered carbon black (Pt/C)...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286359/magnetizable-stent-grafts-enable-endothelial-cell-capture
#16
Brandon J Tefft, Susheil Uthamaraj, J Jonathan Harburn, Ota Hlinomaz, Amir Lerman, Dan Dragomir-Daescu, Gurpreet S Sandhu
Emerging nanotechnologies have enabled the use of magnetic forces to guide the movement of magnetically-labeled cells, drugs, and other therapeutic agents. Endothelial cells labeled with superparamagnetic iron oxide nanoparticles (SPION) have previously been captured on the surface of magnetizable 2205 duplex stainless steel stents in a porcine coronary implantation model. Recently, we have coated these stents with electrospun polyurethane nanofibers to fabricate prototype stent-grafts. Facilitated endothelialization may help improve the healing of arteries treated with stent-grafts, reduce the risk of thrombosis and restenosis, and enable small-caliber applications...
April 1, 2017: Journal of Magnetism and Magnetic Materials
https://www.readbyqxmd.com/read/28286080/electrospun-protein-nanofibers-in-healthcare-a-review
#17
REVIEW
S Babitha, Lakra Rachita, K Karthikeyan, Ekambaram Shoba, Indrakumar Janani, Balan Poornima, K Purna Sai
Electrospun nanofibers are being utilized for a wide range of healthcare applications. A plethora of natural and synthetic polymers are exploited for their ability to be electrospun and replace the complex habitat provided by the extracellular matrix for the cells. The fabrication of nanofibers can be tuned to act as a multicarrier system to deliver drugs, growth factors and health supplements etc. in a sustained manner. Owing to its pliability, nanofibers reached its heights in tissue engineering and drug delivery applications...
March 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28285160/ethanol-dispersed-and-antibody-conjugated-polymer-nanofibers-for-the-selective-capture-and-3-dimensional-culture-of-epcam-positive-cells
#18
Junghyo Yoon, Hee-Sook Yoon, Yoojin Shin, Sanghyun Kim, Youngjun Ju, Jungbae Kim, Seok Chung
Electrospun and ethanol-dispersed polystyrene-poly(styrene-co-maleic anhydride) (PS-PSMA) nanofibers (NFs) were used as a platform for the selective capture and three-dimensional culture of EpCAM-positive cells in cell culture medium and whole blood. The NFs were treated with streptavidin to facilitate bond formation between the amino groups of streptavidin and the maleic anhydride groups of the NFs. A biotinylated anti-EpCAM monoclonal antibody (mAb) was attached to the streptavidin-conjugated NFs via the selective binding of streptavidin and biotin...
March 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28285076/functional-poly-%C3%AE%C2%B5-caprolactone-chitosan-dressings-with-nitric-oxide-releasing-property-improve-wound-healing
#19
Xin Zhou, He Wang, Jimin Zhang, Xuemei Li, Yifan Wu, Yongzhen Wei, Ji Shenglu, Deling Kong, Qiang Zhao
Wound healing dressings are increasingly needed clinically due to the large number of skin damage annually. Nitric oxide (NO) plays a key role in promoting wound healing, thus biomaterials with NO-releasing property receive increasing attention as ideal wound dressing. In present study, we prepared a novel functional wound dressing by combining electrospun poly(ε-caprolactone) (PCL) nonwoven mat with chitosan-based NO-releasing biomaterials (CS-NO). As-prepared PCL/CS-NO dressing released NO sustainably under the physiological conditions, which was controlled by the catalysis of β-galactosidase...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28284833/electrospun-starch-nanofibers-recent-advances-challenges-and-strategies-for-potential-pharmaceutical-applications
#20
REVIEW
Guodong Liu, Zhengbiao Gu, Yan Hong, Li Cheng, Caiming Li
Electrospun starch nanofibers have high porosity, extremely high specific surface area, and biocompatible, biodegradable, and bioabsorbable properties. As a result, starch nanofibers have great potential in pharmaceutical applications, including drug delivery, wound dressing, and tissue engineering. Here, we summarize and review the recent developments in the synthesis of electrospun starch fibers from common starch, modified starch, and hybrids with other polymers. Moreover, the challenges and strategies for the fabrication and application of starch fibers in pharmaceutical applications are presented...
March 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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