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https://www.readbyqxmd.com/read/28732312/drug-eluting-scaffold-inhibited-in-vivo-pancreatic-tumorigenesis-by-engaging-murine-ccr4-cd8-t-cells
#1
Qian Zhan, Baiyong Shen, Yuan Fang, Xiaxing Deng, Hao Chen, Jiabin Jin, Chenghong Peng, Hongwei Li
CCL17 is well known for its ability to engage CCR4(+)CD8(+) T cells, which have been shown to play a critical role in preventing tumorigenesis. In this study, we attempted to inhibit in vivo pancreatic tumorigenesis by engaging murine CCR4(+)CD8(+) T cells through a drug-eluting scaffold with a payload of CCL17. The drug-eluting scaffold was fabricated by electrospinning polyglyconate and porcine gelatin. The electrospun scaffold featured randomly distributed non-woven fibers with diameters ranging from 1μm to 4μm...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28731322/large-scale-stretchable-semi-embedded-copper-nanowires-transparent-conductive-films-by-electrospinning-template
#2
Xia Yang, Xiaotian Hu, Qingxia Wang, Jian Xiong, Hanjun Yang, Xiangchuan Meng, Licheng Tan, Lie Chen, Yiwang Chen
With recent emergence of wearable electronic devices, the flexible and stretchable transparent electrodes are the core components to realize innovative devices. Copper nanowires (CuNWs) network is commonly chosen because of its high conductivity and transparency. However, the junction resistances and low aspect ratios still limit its further stretchable performance. Herein, a large-scale stretchable semi-embedded CuNWs transparent conductive film (TCFs) was fabricated by electrolessly depositing Cu on the electrospun poly (4-vinylpyridine) (P4VP) polymer template semi-embedded in polydimethylsiloxane (PDMS)...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730531/comparing-different-tissue-engineered-repair-materials-for-the-treatment-of-pelvic-organ-prolapse-and-urinary-incontinence-which-material-is-better
#3
Xiaojuan Wang, Yisong Chen, Zhongyong Fan, Keqin Hua
INTRODUCTION AND HYPOTHESIS: Synthetic non-absorbable meshes are widely used to augment surgical repair of pelvic organ prolapse (POP) and stress urinary incontinence (SUI), but these meshes are associated with serious complications. This study compares the attachment and extracellular matrix (ECM) production of adipose-derived stem cells (ADSCs) on different biodegradable nanomaterials to develop tissue engineered repair materials. METHODS: Rat ADSCs were isolated and cultured on electrospun poly-L-lactic acid (PLA) and electrospun poly(L-lactide)-trimethylene carbonate-gycolide (PLTG) terpolymers for 1 and 2 weeks...
July 20, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28730198/programming-shape-and-tailoring-transport-advancing-hygromorphic-bilayers-with-aligned-nanofibers
#4
S L M Alexander, S Ahmadmehrabi, L T J Korley
Natural systems utilize nanofiber architectures to guide water transport, tune mechanical properties, and actuate in response to their environment. In order to harness these properties, a hygromorphic bilayer composite comprised of a self-assembled fiber network and an aligned electrospun fiber network was fabricated. Molecular gel self-assembly was utilized to increase hydrophobicity and strength in one layer, while aligned electrospun poly(vinyl alcohol) (PVA) nanofibers increased the rate of hydration and facilitated tunable actuation in the other...
July 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28728126/electrospun-cerium-based-tio2-nanofibers-for-photocatalytic-oxidation-of-elemental-mercury-in-coal-combustion-flue-gas
#5
Lulu Wang, Yongchun Zhao, Junying Zhang
Photocatalytic oxidation is an attractive method for Hg-rich flue gas treatment. In the present study, a novel cerium-based TiO2 nanofibers was prepared and selected as the catalyst to remove mercury in flue gas. Accordingly, physical/chemical properties of those nanofibers were clarified. The effects of some important parameters, such as calcination temperature, cerium dopant content and different illumination conditions on the removal of Hg(0) using the photocatalysis process were investigated. In addition, the removal mechanism of Hg(0) over cerium-based TiO2 nanofibers focused on UV irradiation was proposed...
July 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28722270/retraction-gold-nanoparticles-immobilized-on-electrospun-titanium-dioxide-nanofibers-for-catalytic-reduction-of-4-nitrophenol
#6
Halit Cavusoglu, Burak Z Buyukbekar, Huseyin Sakalak, Sebastian Kohsakowski
No abstract text is available yet for this article.
July 19, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28721664/reciprocal-influence-of-hmscs-hacat-cultivated-on-electrospun-scaffolds
#7
Sirsendu Bhowmick, Sandra Rother, Heike Zimmermann, Poh S Lee, Stephanie Moeller, Matthias Schnabelrauch, Veena Koul, Dieter Scharnweber
Here, we investigated the synergistic effect of electrospun nanofibrous scaffolds made of gelatin /sulfated hyaluronan (sHA) or native hyaluronan (HA)/chondroitin sulfate (CS) and, keratinocytes (HaCaT)-human mesenchymal stem cells (hMSCs) contact co-culture on epithelial differentiation of hMSCs. The hMSCs were co-cultured in contact with HaCaT cells for 5 days on electrospun scaffold. Results show that electrospun scaffolds containing sulfated glycosaminoglycans (GAGs) stimulate epithelial differentiation in terms of various protein expression markers (keratin 14, ΔNp63α and Pan-cytokeratin) and gene expression of several dermal proteins (keratin 14, ΔNp63α)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28719857/in-situ-adjuvant-therapy-using-a-responsive-doxorubicin-loaded-fibrous-scaffold-after-tumor-resection
#8
Ziming Yuan, Wei Wu, Zhongwei Zhang, Zhiyong Sun, Ruoyu Cheng, Guoqin Pan, Xuemin Wang, Wenguo Cui
As tumor microenvironment becoming more and more important in tumor study, the acid pH around or in solid tumors drew lots of attentions. And the progress of drug delivery systems made the responsive-release possible. This time, we fabricated a new-type composite electrospun poly (L-lactide) (PLLA) fibrous scaffolds, that blent with the mesoporous silica particles (MSNs). Further more, we used sodium bicarbonate (SB) as acid sensitive agent which was wrapped inside the MSNs. And doxorubicin (DOX) was also wrapped into MSNs in order to achieve a sustained release to inhibit tumors in mice, which mimicked the remnant breast cancer with surgery...
July 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28718680/development-of-emu-oil-loaded-pcl-collagen-bioactive-nanofibers-for-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cell-possible-application-in-regenerative-medicine
#9
Kazem Nejati-Koshki, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Abbas Ebrahimi-Kalan, Yousef Mortazavi, Nosratollah Zarghami
Adipose tissue-derived stem cells (ASCs) are promising candidate in stem cell therapies, and maintaining their stemness potential is vital to achieve effective treatment. Natural based scaffolds have been recently attracted increasing attention in nanomedicine and drug delivery. In the present study, a polymeric nanofibrous scaffold was developed based on the polycaprolactone/Collagen (PCL/Coll) containing Emu oil as a bioactive material to induce the proliferation of ASCs, while simultaneously preserve the stemness property of those cells...
July 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28715369/electrospinning-of-photocatalytic-electrodes-for-dye-sensitized-solar-cells
#10
Nicolò Canever, Fraser Hughson, Thomas J Macdonald, Thomas Nann
This work demonstrates a protocol to fabricate a fiber-based photoanode for dye-sensitized solar cells, consisting of a light-scattering layer made of electrospun titanium dioxide nanofibers (TiO2-NFs) on top of a blocking layer made of commercially available titanium dioxide nanoparticles (TiO2-NPs). This is achieved by first electrospinning a solution of titanium (IV) butoxide, polyvinylpyrrolidone (PVP), and glacial acetic acid in ethanol to obtain composite PVP/TiO2 nanofibers. These are then calcined at 500 °C to remove the PVP and to obtain pure anatase-phase titania nanofibers...
June 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28715029/anisotropic-microfibrous-scaffolds-enhance-the-organization-and-function-of-cardiomyocytes-derived-from-induced-pluripotent-stem-cells
#11
Maureen Wanjare, Luqia Hou, Karina H Nakayama, Joseph J Kim, Nicholas P Mezak, Oscar J Abilez, Evangeline Tzatzalos, Joseph C Wu, Ngan F Huang
Engineering of myocardial tissue constructs is a promising approach for treatment of coronary heart disease. To engineer myocardial tissues that better mimic the highly ordered physiological arrangement and function of native cardiomyocytes, we generated electrospun microfibrous polycaprolactone scaffolds with either randomly oriented (14 μm fiber diameter) or parallel-aligned (7 μm fiber diameter) microfiber arrangement and co-seeded the scaffolds with human induced pluripotent stem cell-derived cardiomyocytes (iCMs) and endothelial cells (iECs) for up to 12 days after iCM seeding...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28714176/osteogenic-differentiation-of-3d-cultured-mesenchymal-stem-cells-induced-by-bioactive-peptides
#12
Vera Lukasova, Matej Buzgo, Vera Sovkova, Jana Dankova, Michala Rampichova, Evzen Amler
OBJECTIVES: Bioactive peptides derived from receptor binding motifs of native proteins are a potent source of bioactive molecules that can induce signalling pathways. These peptides could substitute for osteogenesis promoting supplements. The work presented here compares three kinds of bioactive peptides derived from collagen III, bone morphogenetic protein 7 (BMP-7) and BMP-2 with their potential osteogenic activity on the model of porcine mesenchymal stem cells (pMSCs). MATERIALS AND METHODS: pMSCs were cultured on electrospun polycaprolactone nanofibrous scaffolds with different concentrations of the bioactive peptides without addition of any osteogenic supplement...
August 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28714045/characterization-drug-loading-and-antibacterial-activity-of-nanohydroxyapatite-polycaprolactone-nha-pcl-electrospun-membrane
#13
Mohd Izzat Hassan, Naznin Sultana
Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28712345/post-processing-optimization-of-electrospun-sub-micron-poly-3-hydroxybutyrate-fibers-to-obtain-continuous-films-of-interest-in-food-packaging-applications
#14
A Cherpinski, S Torres-Giner, L Cabedo, J M Lagaron
Polyhydroxyalkanoates (PHAs) are one of the most researched family of biodegradable polymers based on renewable materials due to their thermoplastic nature and moisture resistance. The present study was targeted to investigate the preparation and characterization of poly(3-hydroxybutyrate) (PHB) films obtained through the electrospinning technique. To convert them into continuous films, of interest in for instance packaging, the electrospun fiber mats were subsequently post-processed by different physical treatments to optimize their physical performance...
July 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28711834/novel-reusable-porous-polyimide-fibers-for-hot-oil-adsorption
#15
Lidong Tian, Chongyin Zhang, Xiaowei He, Yongqiang Guo, Mingtao Qiao, Junwei Gu, Qiuyu Zhang
The development of oil sorbents with high thermal stability, adsorption capacity, reusability and recoverability is of great significance for hot oil leakage protection, especially for oil spillage of oil refinery, petrochemical industry and cars. In our work, highly efficient hot oil adsorption of polyimide (PI) fibers with excellent thermal stability was successfully prepared by a facile electrospinning method followed by post-treatment. The corresponding morphologies, structures and oil adsorption properties of as-prepared PI fibers at different temperatures were analyzed and characterized...
June 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28711618/fabrication-of-bi-layer-scaffold-of-keratin-nanofiber-and-gelatin-methacrylate-hydrogel-implications-for-skin-graft
#16
Jong Wook Kim, Min Jin Kim, Chang Seok Ki, Hyun Jeong Kim, Young Hwan Park
Bi-layer scaffold composed of human hair keratin/chitosan nanofiber mat and gelatin methacrylate (GelMA) hydrogel was fabricated by using electrospinning and photopolymerization techniques. To prepare the nanofiber layer, the blend solution of human hair keratin and chitosan (mixture ratio: 5/5) was electrospun using formic acid as a solvent in the presence of poly(ethylene glycol), followed by cross-linking with glutaraldehyde. The tensile strength of the human hair keratin/chitosan nanofiber mat was much higher than that of pure human hair keratin nanofiber mat...
July 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28704979/electrospun-polymer-nanofibers-decorated-with-noble-metal-nanoparticles-for-chemical-sensing
#17
REVIEW
Chen Chen, Yongan Tang, Branislav Vlahovic, Fei Yan
The integration of different noble metal nanostructures, which exhibit desirable plasmonic and/or electrocatalytic properties, with electrospun polymer nanofibers, which display unique mechanical and thermodynamic properties, yields novel hybrid nanoscale systems of synergistic properties and functions. This review summarizes recent advances on how to incorporate noble metal nanoparticles into electrospun polymer nanofibers and illustrates how such integration paves the way towards chemical sensing applications with improved sensitivity, stability, flexibility, compatibility, and selectivity...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28702219/modification-and-optimization-of-electrospun-gelatin-sheets-by-electron-beam-irradiation-for-soft-tissue-engineering
#18
Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park, Oh Hyeong Kwon
BACKGROUND: Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell migration and tissue regeneration. Here, we investigated the optimal electron beam (e-beam) irradiation doses with biodegradation behavior on changes in the molecular weight, morphology, pore structure, and cell proliferation profiles of electrospun nanofibrous gelatin sheets...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28699921/enhanced-piezoresponse-of-highly-aligned-electrospun-poly-vinylidene-fluoride-nanofibers
#19
Sung Bum Kang, Sang Hyuk Won, Min Ji Im, Chan Ul Kim, Won Il Park, Jeong Min Baik, Kyoung Jin Choi
Well-ordered nanostructure arrays with controlled densities can potentially improve material properties; however, their fabrication typically involves the use of complicated processing techniques. In this work, we demonstrate a uniaxial alignment procedure for fabricating poly(vinylidene fluoride) (PVDF) electrospun nanofibers (NFs) by introducing collectors with additional steps. The mechanism of the observed NF alignment, which occurs due to the concentration of lateral electric field lines around collector steps, has been elucidated via finite-difference time-domain simulations...
July 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28699660/binding-of-indocyanine-green-in-polycaprolactone-fibers-using-blend-electrospinning-for-in-vivo-laser-assisted-vascular-anastomosis
#20
Annemarie Schönfeld, Zacharia Mbäıdjol Kabra, Mihai Constantinescu, Dieter Bosshardt, Michael H Stoffel, Kirsten Peters, Martin Frenz
BACKGROUND AND OBJECTIVE: The clinical application of laser-assisted vascular anastomosis is afflicted by unreliable and low bonding strengths as well as tedious handling during microvascular surgery. The challenge to be met arises from the flow-off of the chromophore during soldering that changes the absorption and stains the surrounding tissue, leading to an uncontrollable thermal damage zone. In this study, we investigated the feasibility to produce an indocyanine green (ICG)-loaded patch by electrospinning and tested its applicability to both in vitro and in vivo microvascular laser soldering...
July 12, 2017: Lasers in Surgery and Medicine
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