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https://www.readbyqxmd.com/read/28645765/chitosan-surface-modified-electrospun-poly-%C3%AE%C2%B5-caprolactone-carbon-nanotube-composite-fibers-with-enhanced-mechanical-cell-proliferation-and-antibacterial-properties
#1
Siyu Wang, Yumei Li, Rui Zhao, Toufeng Jin, Li Zhang, Xiang Li
The surface modification is one of the most effective methods to improve the bioactivity and cell affinity effect of electrospun poly(ε-caprolactone) (PCL) fibers. In the present study, chitosan (CS), a cationic polysaccharide, was used to modify the surface of electrospun PCL fibers. To obtain strong interaction between CS and PCL fibers, negatively charged PCL fibers were prepared by the incorporation of acid-treated carbon nanotubes (CNTs) into the fibers. In this way, the positively charged chitosan could be immobilized onto the surface of PCL fibers tightly by the electrostatic attraction...
June 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28644620/nanofibrous-smart-fabrics-from-twisted-yarns-of-electrospun-piezo-polymer
#2
Enlong Yang, Zhe Xu, Lucas Chur, Ali Behroozfar, Mahmoud Baniasadi, Salvador Moreno, Jiacheng Huang, Jules Gilligan, Majid Minary-Jolandan
Smart textiles are envisioned to make a paradigm shift in wearable technologies to directly impart functionality into the fibers rather than integrating sensors and electronics onto conformal substrates or skin in wearable devices. Among smart materials, piezoelectric fabrics have not been widely reported, yet. Piezoelectric smart fabrics can be used for mechanical energy harvesting, for thermal energy harvesting through the pyroelectric effect, for ferroelectric applications, as pressure and force sensors, for motion detection, and for ultrasonic sensing...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28644611/transient-fiber-mats-of-electrospun-poly-propylene-carbonate-composites-with-remarkable-mechanical-strength
#3
Peter Ohlendorf, Alexander Ruyack, Amanda K Leonardi, Chengjian Shi, Christine Cuppoletti, Ian Bruce, Amit Lal, Christopher K Ober
Polymers with a triggered decomposition are attractive for an array of applications ranging from patterning to transient packaging materials as well as for environmental protection. This work showed for the first time UV and thermally triggered transience in fiber mats using poly(propylene carbonate) (PPC) composites. The electrospun PPC-composite fiber mats combine excellent decomposition performance (due to the high surface to volume ratio) with high stiffness and thus represent a new class of materials enabling innovative applications such as transient filter materials, short-time plant protection materials as well as temporary lightweight materials for aerospace engineering...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28643700/a-design-of-experiments-doe-approach-to-identify-the-influencing-parameters-that-determine-poly-d-l-lactic-acid-pdlla-electrospun-scaffold-morphologies
#4
Floor Agnes Andrea Ruiter, Cameron Alexander, Felicity Rose, Joel Segal
Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology...
June 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28642016/electrospun-vascular-scaffold-for-cellularized-small-diameter-blood-vessels-a-preclinical-large-animal-study
#5
Young Min Ju, Hyunhee Ahn, Juan Arenas-Herrera, Cheil Kim, Mehran Abolbashari, Anthony Atala, James J Yoo, Sang Jin Lee
The strategy of vascular tissue engineering is to create a vascular substitute by combining autologous vascular cells with a tubular-shaped biodegradable scaffold. We have previously developed a novel electrospun bilayered vascular scaffold that provides proper biological and biomechanical properties as well as structural configuration. In this study, we investigated the clinical feasibility of a cellularized vascular scaffold in a preclinical large animal model. We fabricated the cellularized vascular construct with autologous endothelial progenitor cell (EPC)-derived endothelial cells (ECs) and smooth muscle cells (SMCs) followed by a pulsatile bioreactor preconditioning...
June 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28641554/future-of-spermatogonial-stem-cell-culture-application-of-nanofiber-scaffolds
#6
Azar Shams, Neda Eslahi, Mansoureh Movahedin, Fariborz Izadyar, Hamidreza Asgari, Morteza Koruji
The spermatogonial stem cells (SSCs) are unique in mammals because they can transmit genetic information from generation to generation and it is of significant importance. In testes, Sertoli cells, peritubular myoid cells, Leydig cells and other interstitial cells contribute to the spermatogonial stem cell "niche". So, creation of niche in in vitro condition that mimics in vivo environment is essential to maintain functional characteristic of SSCs. Nanofiber matrices mimic the architecture and size scale of the natural extracellular matrix (ECM)...
June 22, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28640316/electrospun-graphene-wrapped-na6-24fe4-88-p2o7-4-nanofibers-as-a-high-performance-cathode-for-sodium-ion-batteries
#7
Yubin Niu, Maowen Xu, Chunlong Dai, Bolei Shen, Chang Ming Li
Na6.24Fe4.88(P2O7)4 is one of the intensively investigated polyanionic compounds and has shown high rate discharge capacity, but its relatively low electronic conductivity hampers the high performance of the batteries. Herein for the first time we report new graphene wrapped Na6.24Fe4.88(P2O7)4 composite nanofibers (NFPO@C@rGO) made from electrospinning for cathodes of SIBs to achieve an even higher performance with a highly stable discharge capacity of ∼99 mA h g(-1) at a current density of 40 mA g(-1) after 320 cycles, which is 1...
June 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28639518/selective-laser-melting-enabled-electrospinning-introducing-complexity-within-electrospun-membranes
#8
Thomas E Paterson, Selina N Beal, Martin E Santocildes-Romero, Alfred T Sidambe, Paul V Hatton, Ilida Ortega Asencio
Additive manufacturing technologies enable the creation of very precise and well-defined structures that can mimic hierarchical features of natural tissues. In this article, we describe the development of a manufacturing technology platform to produce innovative biodegradable membranes that are enhanced with controlled microenvironments produced via a combination of selective laser melting techniques and conventional electrospinning. This work underpins the manufacture of a new generation of biomaterial devices that have significant potential for use as both basic research tools and components of therapeutic implants...
June 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28637349/the-antibacterial-polyamide-6-zno-hierarchical-nanofibers-fabricated-by-atomic-layer-deposition-and-hydrothermal-growth
#9
Zhengduo Wang, Li Zhang, Zhongwei Liu, Lijun Sang, Lizhen Yang, Qiang Chen
In this paper, we report the combination of atomic layer deposition (ALD) with hydrothermal techniques to deposit ZnO on electrospun polyamide 6 (PA 6) nanofiber (NF) surface in the purpose of antibacterial application. The micro- and nanostructures of the hierarchical fibers are characterized by field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HRTEM), and scanning transmission electron microscopy (STEM). We find that NFs can grow into "water lily"- and "caterpillar"-like shapes, which depend on the number of ALD cycles and the hydrothermal reaction period...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28636337/thermal-annealing-to-modulate-the-shape-memory-behavior-of-a-biobased-and-biocompatible-triblock-copolymer-scaffold-in-the-human-body-temperature-range
#10
Andrea Merlettini, Matteo Gigli, Martina Ramella, Chiara Gualandi, Michelina Soccio, Francesca Boccafoschi, Andrea Munari, Nadia Lotti, Maria Letizia Focarete
A biodegradable and biocompatible electrospun scaffold with shape memory behavior in the physiological temperature range is here presented. It was obtained starting from a specifically designed, biobased PLLA-based triblock copolymer, where the central block is poly(propylene azelate-co-propylene sebacate), (P(PAz60PSeb40)) random copolymer. Shape memory properties are determined by the contemporary presence of the low melting crystals of the P(PAz60PSeb40) block, acting as switching segment, and of the high melting crystal phase of PLLA blocks, acting as physical network...
June 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28636335/a2b-miktoarm-glycopolymer-fibers-and-their-interactions-with-tenocytes
#11
Renjie Liu, Dharmesh Patel, Hazel R C Screen, C Remzi Becer
Electrospun biodegradable membranes have attracted great attention for a range of tissue engineering applications. Among them, poly (ε-caprolactone) (PCL) is one of the most widely used polymers, owing to its well-controlled biocompatibility and biodegradability. However, PCL also has a number of limitations, such as its hydrophobic nature and the lack of functional groups on its side chain, limiting its ability to interact with cells. Herein, we have designed and prepared a series of well-defined A2B-miktoarm copolymers with PCL and glycopolymer segments to address these limitations...
June 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28636088/multicompartment-drug-release-system-for-dynamic-modulation-of-tissue-responses
#12
Aaron H Morris, Rajwant S Mahal, Jillian Udell, Michelle Wu, Themis R Kyriakides
Pharmacological modulation of responses to injury is complicated by the need to deliver multiple drugs with spatiotemporal resolution. Here, a novel controlled delivery system containing three separate compartments with each releasing its contents over different timescales is fabricated. Core-shell electrospun fibers create two of the compartments in the system, while electrosprayed spheres create the third. Utility is demonstrated by targeting the foreign body response to implants because it is a dynamic process resulting in implant failure...
June 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28635132/the-fabrication-of-iron-oxide-nanoparticle-nanofiber-composites-by-electrospinning-and-their-applications-in-tissue-engineering
#13
REVIEW
Chris J Mortimer, Chris J Wright
This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun materials offering a high surface area to volume ratio, potential for the release of drugs and antimicrobials, controllable fiber diameters and high porosity and permeability. A number of different techniques for the preparation of iron oxide nanoparticles including their functionalization are discussed along with their applications in the biomedical field...
June 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28633856/using-of-sonochemically-prepared-sbsi-for-electrospun-nanofibers
#14
M Nowak, T Tański, P Szperlich, W Matysiak, M Kępińska, D Stróż, Ł Bober, B Toroń
A novel polymeric, polyacrylonitrile (PAN) nanofibers containing ferroelectric and semiconducting antimony sulfoiodide (SbSI) have been made by electrospinning. SbSI nanowires, used as the filler, have been prepared sonochemically from antimony sulphide (Sb2S3) and antimony tri-iodide (SbI3) for the first time. Nanocrystalline SbSI has been fabricated in ethanol under ultrasonic irradiation (20kHz, 565W/cm(2)) at 323K within 2h. The products have been characterized by using techniques such as powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, high-resolution transmission electron microscopy, selected area electron diffraction and optical diffuse reflection as well as transmission spectroscopy...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28632137/electrospun-silk-polyaniline-conduits-for-functional-nerve-regeneration-in-rat-sciatic-nerve-injury-model
#15
Suradip Das, Manav Sharma, Dhiren Saharia, Kushal Sarma, Elizabeth Muir, Utpal Bora
The present study describes the fabrication of polyaniline-silk fibroin nanocomposite based nerve conduits and its subsequent implantation in a rat sciatic nerve injury model for peripheral nerve regeneration. This is the first in vivo study of polyaniline based nerve conduit describing the safety and efficacy of the conduits in treating peripheral nerve injuries. The nanocomposite was synthesised by electrospinning a mixture of silk fibroin protein and polyaniline wherein the silk nanofibers were observed to be uniformly coated with polyaniline nanoparticles...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28631613/repairing-a-bone-defect-with-a-three-dimensional-cellular-construct-composed-of-a-multi-layered-cell-sheet-on-electrospun-mesh
#16
Zhiwei Ren, Shiqing Ma, Le Jin, Zihao Liu, Deping Liu, Xu Zhang, Qing Cai, Xiaoping Yang
In addition to providing maneuverability, electrospun nanofibrous meshes can make excellent supports for constructing flexible cell sheets to regulate cell behavior by nanofiber features. With the target of bone regeneration, herein composite nanofibers with two different fiber arrangements (nestlike, random) were electrospun from a blend solution containing poly(l-lactide) (PLLA) and gelatin (1:1 in weight ratio). Unlike the non-woven morphology in a random nanofibrous mesh, PLLA/gelatin composite nanofibers in the nestlike nanofibrous mesh displayed both non-woven and parallel morphologies...
June 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28631375/3d-mimicry-of-native-tissue-fiber-architecture-guides-tendon-derived-cells-and-adipose-stem-cells-into-artificial-tendon-constructs
#17
Mariana Laranjeira, Rui M A Domingues, Raquel Costa-Almeida, Rui L Reis, Manuela E Gomes
Tendon and ligament (T/L) function is intrinsically related with their unique hierarchically and anisotropically organized extracellular matrix. Their natural healing capacity is, however, limited. Here, continuous and aligned electrospun nanofiber threads (CANT) based on synthetic/natural polymer blends mechanically reinforced with cellulose nanocrystals are produced to replicate the nanoscale collagen fibrils grouped into microscale collagen fibers that compose the native T/L. CANT are then incrementally assembled into 3D hierarchical scaffolds, resulting in woven constructions, which simultaneously mimic T/L nano-to-macro architecture, nanotopography, and nonlinear biomechanical behavior...
June 20, 2017: Small
https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#18
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629050/novel-bilayer-wound-dressing-based-on-electrospun-gelatin-keratin-nanofibrous-mats-for-skin-wound-repair
#19
Chun-Hsu Yao, Chia-Yu Lee, Chiung-Hua Huang, Yueh-Sheng Chen, Kuo-Yu Chen
A bilayer membrane (GKU) with a commercial polyurethane wound dressing as an outer layer and electrospun gelatin/keratin nanofibrous mat as an inner layer was fabricated as a novel wound dressing. Scanning electron micrographs showed that gelatin/keratin nanofibers had a uniform morphology and bead-free structure with average fiber diameter of 160.4nm. 3-(4,5-Dimethylthiazolyl)-2,5-diphenyltetrazolium bromide assay using L929 fibroblast cells indicated that the residues released from the gelatin/keratin composite nanofibrous mat accelerated cell proliferation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629047/two-phase-electrospinning-to-incorporate-growth-factors-loaded-chitosan-nanoparticles-into-electrospun-fibrous-scaffolds-for-bioactivity-retention-and-cartilage-regeneration
#20
Chongyang Wang, Wenxiu Hou, Xuran Guo, Juehong Li, Tu Hu, Manle Qiu, Shen Liu, Xiumei Mo, Xudong Liu
Growth factor is an essential ingredient to regulate mesenchymal stem cells (MSCs) chondrogenic differentiation in cartilage tissue engineering. However, non-osteochondral specification, short plasma half time and bioactivity loss restrict growth factor's application. Thus, novel chondrogenic growth factors, specifically target osteochondral lineage cells, that can be sustained release and bioactivity protected to exert functions continually and effectively have attracted increasing researchers' interest. To achieve these goals, chitosan nanoparticles and electrospun fiber scaffolds were used as dual release system to sustain release Nel-like molecule-1 (Nell-1) growth factor and protect bioactivity, then the effect and mechanism of Nell-1 on inducing human bone MSCs (hBMSCs) differentiate toward chondrocytes were investigated...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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