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https://www.readbyqxmd.com/read/29168916/fabrication-characterization-and-biocompatibility-assessment-of-a-novel-elastomeric-nanofibrous-scaffold-a-potential-scaffold-for-soft-tissue-engineering
#1
Elham Shamirzaei Jeshvaghani, Laleh Ghasemi-Mobarakeh, Reza Mansurnezhad, Fatemeh Ajalloueian, Mahshid Kharaziha, Mohammad Dinari, Maryam Sami Jokandan, Ioannis S Chronakis
With regard to flexibility and strength properties requirements of soft biological tissue, elastomeric materials could be more beneficial in soft tissue engineering applications. The present work investigates the use of an elastic polymer, (polycaprolactone fumarate [PCLF]), for fabricating an electrospun scaffold. PCLF with number-average molecular weight of 13,284 g/mol was synthetized, electrospun PCLF:polycaprolactone (PCL) (70:30) nanofibrous scaffolds were fabricated and a novel strategy (in situ photo-crosslinking along with wet electrospinning) was applied for crosslinking of PCLF in the structure of PCLF:PCL nanofibers was presented...
November 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29168853/electrospun-flexible-poly-bisphenol-a-carbonate-nanofibers-decorated-with-ag-nanoparticles-as-effective-3d-sers-substrates-for-trace-tnt-detection
#2
Yi Li, Rui Lu, Jinyou Shen, Weiqing Han, Xiuyun Sun, Jiansheng Li, Lianjun Wang
A flexible 3D hybrid PC/Ag surface-enhanced Raman scattering (SERS) substrate was fabricated through the combination of electrospinning and in situ chemical reduction. Due to the rough surface morphology and the intricate 3D structure, a high density of Raman "hotspots" was formed at the junctions of cross-linked nanofibers, resulting in excellent sensitivity to a probe molecule (4-aminothiophenol). The nanofibers were modified with l-cysteine to capture TNT molecules by the formation of a Meisenheimer complex, after which positively charged 4-ATP-labelled AgNPs were introduced to the system, which both generated more hotspots and led to a linear relationship between the TNT concentration and the SERS intensity of the labelled molecules...
November 23, 2017: Analyst
https://www.readbyqxmd.com/read/29166026/electrospun-thin-walled-cuco2o4-c-nanotubes-as-bifunctional-oxygen-electrocatalysts-for-rechargeable-zn-air-batteries
#3
Xiaojun Wang, Yang Li, Ting Jin, Jing Meng, Lifang Jiao, Min Zhu, Jun Chen
Rational design of optimal bifunctional oxygen electrocatalyst with low cost and high activity is greatly desired for realization of rechargeable Zn-air batteries. Herein, we fabricate mesoporous thin-walled CuCo2O4@C with abundant nitrogen-doped nanotubes via coaxial electrospinning technique. Benefiting from high catalytic activity of ultrasmall CuCo2O4 particles, double active specific surface area of mesoporous nanotubes, and strong coupling with N-doped carbon matrix, the obtained CuCo2O4@C exhibits outstanding oxygen electrocatalytic activity and stability, which in terms of a positive onset potential (0...
November 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/29165317/the-effect-of-electrospun-polycaprolactone-scaffold-morphology-on-human-kidney-epithelial-cells
#4
Todd P Burton, Anthony Corcoran, Anthony Callanan
There is a pressing need for further advancement in tissue engineering of functional organs with a view to providing a more clinically relevant model for drug development and reduce the dependence on organ donation. Polymer-based scaffolds, such as polycaprolactone (PCL), have been highlighted as a potential avenue for tissue engineered kidneys, but there is little investigation down this stream. Focus within kidney tissue engineering has been on two-dimensional cell culture and decellularised tissue. Electrospun polymer scaffolds can be created with a variety of fibre diameters and have shown a great potential in many areas...
November 22, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29164856/aerosol-crosslinked-crown-ether-diols-melded-with-poly-vinyl-alcohol-as-specialized-microfibrous-li-adsorbents
#5
Lawrence A Limjuco, Grace Masbate Nisola, Rey Eliseo Castillo Torrejos, Jeong Woo Han, Ho Seong Song, Khino J Parohinog, Sangho Koo, Seong-Poong Lee, Wook-Jin Chung
Crown ether (CE)-based Li(+) adsorbent microfibers (MFs) were successfully fabricated through a combined use of CE diols, electrospinning, and aerosol crosslinking. The 14-16 membered CEs, with varied ring sub-units and cavity dimensions, have two hydroxyl groups for covalent attachments to poly(vinyl alcohol) (PVA) as the chosen matrix. The CE diols were blended with PVA and transformed into microfibers via electrospinning, a highly effective technique in minimizing CE loss during MF fabrication. Subsequent aerosol glutaraldehyde (GA) crosslinking of the electrospun CE/PVA MFs stabilized the adsorbents in water...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29162855/three-dimensional-honeycomb-patterned-fibrinogen-based-nanofibers-induce-substantial-osteogenic-response-of-mesenchymal-stem-cells
#6
Salima Nedjari, Firas Awaja, George Altankov
Stem cells therapy offers a viable alternative for treatment of bone disorders to the conventional bone grafting. However clinical therapies are still hindered by the insufficient knowledge on the conditions that maximize stem cells differentiation. Hereby, we introduce a novel 3D honeycomb architecture scaffold that strongly support osteogenic differentiation of human adipose derived mesenchymal stem cells (ADMSCs). The scaffold is based on electrospun hybrid nanofibers consisting of poly (L-lactide ε-caprolactone) and fibrinogen (PLCL/FBG)...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162461/compressed-collagen-constructs-with-optimized-mechanical-properties-and-cell-interactions-for-tissue-engineering-applications
#7
Fatemeh Ajalloueian, Nikolaos Nikogeorgos, Ali Ajalloueian, Magdalena Fossum, Seunghwan Lee, Ioannis S Chronakis
In this study, we are introducing a simple, fast and reliable add-in to the technique of plastic compression (PC) to obtain collagen sheets with decreased fibrillar densities, representing improved cell-interactions and mechanical properties. Collagen hydrogels with different initial concentrations (1.64mg/mL-0.41mg/mL) were compressed around an electrospun sheet of PLGA. The scaffolds were then studied as non-seeded, or seeded with 3T3 fibroblast cells and cultured for 7 days. Confocal microscopy and TEM imaging of non-seeded scaffolds showed that by decreasing the share of collagen in the hydrogel formula, collagen sheets with similar thickness but lower fibrous densities were achieved...
November 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29155732/fabrication-and-characterization-of-griffithsin-modified-fiber-scaffolds-for-prevention-of-sexually-transmitted-infections
#8
Hung R Vuong, Kevin M Tyo, Jill M Steinbach-Rankins
Electrospun fibers (EFs) have been widely used in a variety of therapeutic applications; however, they have only recently been applied as a technology to prevent and treat sexually transmitted infections (STIs). Moreover, many EF technologies focus on encapsulating the active agent, relative to utilizing the surface to impart biofunctionality. Here we describe a method to fabricate and surface-modify poly(lactic-co-glycolic) acid (PLGA) electrospun fibers, with the potent antiviral lectin Griffithsin (GRFT)...
October 31, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29152562/fast-dissolving-dendrimer-nanofiber-mats-as-alternative-to-eye-drops-for-more-efficient-antiglaucoma-drug-delivery
#9
Michael G Lancina, Sudha Singh, Uday B Kompella, Shahid Husain, Hu Yang
Polyamidoamine (PAMAM) dendrimers have been investigated as a potential platform for a number of ocular drugs, but only in aqueous solution. In this work we have developed fast dissolving dendrimer-based nanofibers (DNF) as a topical delivery vehicle for the glaucoma drug brimonidine tartrate (BT). The safety and drug release kinetics of these nanofiber mats were evaluated in vitro and in vivo. DNF caused no toxicity at therapeutic levels in cultured cells or ocular irritation in animal tests using a normotensive rat model...
August 14, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29150802/ion-imprinted-electrospun-nanofibers-of-chitosan-1-butyl-3-methylimidazolium-tetrafluoroborate-for-the-dynamic-expulsion-of-thorium-iv-ions-from-mimicked-effluents
#10
Prakash Macchindra Gore, Latika Khurana, Suhail Siddique, Anjana Panicker, Balasubramanian Kandasubramanian
The present study explores the innocuous, biocompatible, and extremely competent molecularly imprinted chitosan/RTIL electrospun nanofibers having average diameter of 30 nm for the expulsion of thorium (IV) ions from the mimicked effluent waste. The extended Flory-Huggins theory and three-dimensional molecular modeling have been effectively premeditated via Materials Studio software for enumerating the inter-miscibility and compatibility (Chi parameter (χ) = 1.019, mixing energy (Emix) = 0.603 kcal/mol) of the chitosan/RTIL (1-butyl-3-methylimidazolium tetrafluoroborate)...
November 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29149727/surface-modification-of-electrospun-poly-l-lactic-acid-scaffolds-by-reactive-magnetron-sputtering
#11
E N Bolbasov, P V Maryin, K S Stankevich, A I Kozelskaya, E V Shesterikov, Yu I Khodyrevskaya, M V Nasonova, D K Shishkova, Yu A Kudryavtseva, Y G Anissimov, S I Tverdokhlebov
In this study, we modified the surface of bioresorbable electrospun poly-(l-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity...
November 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29148704/electrospun-poly-3-hydroxybutyrate-co-4-hydroxybutyrate-graphene-oxide-scaffold-enhanced-properties-and-promoted-in-vivo-bone-repair-in-rats
#12
Tengfei Zhou, Guo Li, Shiyu Lin, Taoran Tian, Quanquan Ma, Qi Zhang, Sirong Shi, Changyue Xue, Wenjuan Ma, Xiaoxiao Cai, Yunfeng Lin
Bone tissue engineering emerges as an advantageous technique to achieve tissue regeneration. Scaffolds for it must present excellent biomechanical properties where bare polymers poorly perform. Development for new biomaterials with high osteogenic capacity is urgently pursued. In this study, an electrospun poly(3-hydroxybutyrate-co-4-hydroxybutyrate/graphene oxide (P34HB/GO) nanofibrous scaffold is successfully fabricated and characterized. The effects of GO amount on scaffold morphology, biomechanical properties, and cellular behaviors are investigated...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29143442/development-of-biomimetic-thermoplastic-polyurethane-fibroin-small-diameter-vascular-grafts-via-a-novel-electrospinning-approach
#13
Emily Yu, Hao-Yang Mi, Jue Zhang, James A Thomson, Lih-Sheng Turng
A new electrospinning approach for fabricating vascular grafts with a layered, circumferentially aligned, and micro-wavy fibrous structure similar to natural elastic tissues has been developed. The customized electrospinning collector was able to generate wavy fibers using the dynamic "jump rope" collecting process, which also solved the sample removal problem for mandrel-type collectors. In this study, natural silk fibroin and synthetic thermoplastic polyurethane (TPU) were combined at different weight ratios to produce hybrid small-diameter vascular grafts...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29141043/lateral-migration-of-electrospun-hydrogel-nanofilaments-in-an-oscillatory-flow
#14
Sylwia Pawłowska, Paweł Nakielski, Filippo Pierini, Izabela K Piechocka, Krzysztof Zembrzycki, Tomasz A Kowalewski
The recent progress in bioengineering has created great interest in the dynamics and manipulation of long, deformable macromolecules interacting with fluid flow. We report experimental data on the cross-flow migration, bending, and buckling of extremely deformable hydrogel nanofilaments conveyed by an oscillatory flow into a microchannel. The changes in migration velocity and filament orientation are related to the flow velocity and the filament's initial position, deformation, and length. The observed migration dynamics of hydrogel filaments qualitatively confirms the validity of the previously developed worm-like bead-chain hydrodynamic model...
2017: PloS One
https://www.readbyqxmd.com/read/29139517/nanofibre-preparation-of-non-processable-polymers-by-solid-state-polymerization-of-molecularly-self-assembled-monomers
#15
Jian Zhu, Yichun Ding, Seema Agarwal, Andreas Greiner, Hean Zhang, Haoqing Hou
Polybisbenzimidazobenzophenanthroline-dione (BBB) is a high-performance polymer which is characterized by very high mechanical strength in combination with exceptional thermal stability, but it cannot be processed to electrospun fibres for any useful applications due to its insolubility and infusibility. We overcame all obstacles in the electrospinning of BBB by a new bottom-up, and facile approach for the solid-state polymerization of self-assembled monomer precursors. Key to this new strategy is the incorporation of a high molecular weight sacrificial polymer to aid in fibre formation...
November 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/29138566/studies-on-the-use-of-recombinant-spider-silk-protein-polyvinyl-alcohol-electrospinning-membrane-as-wound-dressing
#16
Liang Zhao, Denglong Chen, Qinghua Yao, Min Li
A series of wound membranes of polyvinyl alcohol and recombinant spider silk protein (pNSR16) was prepared by electrospinning. The membrane was analyzed by scanning electron microscopy, atomic force microscopy, and Fourier transform infrared spectroscopy. The result showed that the three factors that affected average fiber diameter from high to low were, voltage, flow speed, and solidification distance; and the three factors that affected fiber uniformity from high to low were, flow speed, solidification distance, and voltage...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29134948/effect-of-scaffold-morphology-and-cell-co-culture-on-tenogenic-differentiation-of-hadmsc-on-centrifugal-melt-electrospun-poly-l%C3%A2-lactic-acid-fibrous-meshes
#17
Shaohua Wu, Hao Peng, Xiuhong Li, Philipp N Streubel, Yong Liu, Bin Duan
Engineered tendon grafts offer a promising alternative for grafting during the reconstruction of complex tendon tears. The tissue-engineered tendon substitutes have the advantage of increased biosafety and the option to customize their biochemical and biophysical properties to promote tendon regeneration. In this study, we developed a novel centrifugal melt electrospinning (CME) technique, with the goal of optimizing the fabrication parameters to generate fibrous scaffolds for tendon tissue engineering. The effects of CME processing parameters, including rotational speed, voltage, and temperature, on fiber properties (i...
November 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/29134814/direct-uv-triggered-thiol-ene-cross-linking-of-electrospun-polyester-fibers-from-unsaturated-poly-macrolactone-s-and-their-drug-loading-by-solvent-swelling
#18
Fernando C S de Oliveira, Dinorath Olvera, Michael J Sawkins, Sally-Ann Cryan, Scott D Kimmins, Tatiane Eufrasio da Silva, Daniel J Kelly, Garry P Duffy, Cathal Kearney, Andreas Heise
Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined fibers with an average diameter of 9 μm is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology...
November 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29134783/electrospun-titania-fiber-mats-spin-coated-with-thin-polymer-films-as-nanofibrous-scaffolds-for-enhanced-cell-proliferation
#19
Alfin Kurniawan, Chintya Effendi, Meng-Jiy Wang
The incorporation of inorganic materials into electrospun nanofibers has recently gained considerable attention for the development of ECM-like scaffolds with improved mechanical properties and enhanced biological functions for tissue engineering applications. In this study, polymer-inorganic composite fibers consisting of poly(2-ethyl-2-oxazoline) (PEOXA) and tetrabutyl titanate (TBT) as the titanium precursor were successfully fabricated through a combined sol-gel/electrospinning approach. PEOXA/Ti(OR)n composite fibers were obtained with varying amounts of polymer and titanium precursors...
November 14, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29133923/alignment-of-multiple-electrospun-piezoelectric-fiber-bundles-across-serrated-gaps-at-an-incline-a-method-to-generate-textile-strain-sensors
#20
Yu-Hsiang Hsu, Chen-Hao Chan, William C Tang
In this paper, we report a new type of electrospinning collector that allows simultaneous collection and alignment of multiple poly(vinylidene fluoride-trifluoroethylene) piezoelectric fiber bundles with a controlled separation. The key enabling feature is the serrated teeth along the edges across an inclined gap as a part of the conductive collector. As a result, the electrical field across the gap is shaped to direct the electrospun fibers to merge into multiple bundles. The sharp points on the serrated teeth provide favorable charge dissipation points and thus fibers are preferentially formed bridging two closest sharp points across the gap...
November 13, 2017: Scientific Reports
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