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https://www.readbyqxmd.com/read/29771629/brain-uptake-of-multivalent-and-multi-specific-dvd-ig-proteins-after-systemic-administration
#1
Denise Karaoglu Hanzatian, Annette Schwartz, Farid Gizatullin, Jamie Erickson, Kangwen Deng, Ruth Villanueva, Christopher Stedman, Cristina Harris, Tariq Ghayur, Andrew Goodearl
Therapeutic monoclonal antibodies and endogenous IgG antibodies show limited uptake into the central nervous system (CNS) due to the blood-brain barrier (BBB), which regulates and controls the selective and specific transport of both exogenous and endogenous materials to the brain. The use of natural transport mechanisms, such as receptor-mediated transcytosis (RMT), to deliver antibody therapeutics into the brain have been studied in rodents and monkeys. Recent successful examples include monovalent bispecific antibodies and mono- or bivalent fusion proteins; however, these formats do not have the capability to bind to both the CNS target and the BBB transport receptor in a bivalent fashion as a canonical antibody would...
May 17, 2018: MAbs
https://www.readbyqxmd.com/read/29747358/-the-causative-diseases-common-comorbidities-and-surgical-procedures-of-948-cases-of-horizontal-sensory-strabismus
#2
L Yin, X Chen
Objective: To investigate the common causes, onset age of vision impairment and complications of sensory strabismus, and to explore the effective surgical methods for sensory strabismus and associated complications. Methods: In this retrospective study, there were 948 cases of surgical treatment for sensory strabismus from 2005 to 2015 in Tianjin Eye Hospital, including 822 cases of sensory exotropia and 126 cases of sensory esotropia. Causative disease, onset age of vision impairment, eye movement, horizontal and vertical deviation and surgical methods were evaluated...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29735473/exercise-therapy-interventions-in-patients-with-hip-osteoarthritis-comparison-of-the-effects-of-dvd-and-website-based-interventions
#3
Yuko Uesugi, Junichiro Koyanagi, Keishi Takagi, Ryota Yamaguchi, Shinya Hayashi, Takashi Nishii
BACKGROUND: Prevalence of developmental hip dysplasia is high in Japan. Exercise therapy has been proven effective to treat certain aspects of hip osteoarthritis. Moreover, therapy provided via digital video discs (DVDs) and websites allows patients to exercise in the comfort of their own homes. However, no studies have evaluated the effectiveness of visual instructions in patients with hip disorders. OBJECTIVE: This study aimed to compare the effectiveness of exercise therapy administered via DVD and that administered via a website...
May 7, 2018: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/29725508/the-relationship-amongst-intervertebral-disc-vertical-diameter-lateral-foramen-diameter-and-nerve-root-impingement-in-lumbar-vertebra
#4
M I Yusof, M N Hassan, M S Abdullah
Introduction: The vertical diameter of the foramen is dependent upon the vertical diameter of the corresponding intervertebral disc. A decrease in disc vertical diameter has direct anatomic consequences to the foraminal diameter and area available for the nerve root passing through it. This study is to establish the relationship amongst the intervertebral disc vertical diameter, lateral foramen diameters and nerve root compression in the lumbar vertebra. Materials and Methods: Measurements of the study parameters were performed using sagittal MRI images...
March 2018: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29718733/development-of-a-multimedia-educational-programme-for-first-time-hearing-aid-users-a-participatory-design
#5
Melanie Ferguson, Paul Leighton, Marian Brandreth, Heather Wharrad
OBJECTIVE: To develop content for a series of interactive video tutorials (or reusable learning objects, RLOs) for first-time adult hearing aid users, to enhance knowledge of hearing aids and communication. DESIGN: RLO content was based on an electronically-delivered Delphi review, workshops, and iterative peer-review and feedback using a mixed-methods participatory approach. STUDY SAMPLE: An expert panel of 33 hearing healthcare professionals, and workshops involving 32 hearing aid users and 11 audiologists...
May 2, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29701460/highly-tunable-and-scalable-fabrication-of-3d-flexible-graphene-micropatterns-for-directing-cell-alignment
#6
Jiao Yang Lu, Xin Xing Zhang, Qiu Yan Zhu, Fu Rui Zhang, Wei Tao Huang, Xue Zhi Ding, Li Qiu Xia, Hong Qun Luo, Nian Bing Li
Patterning graphene allows to precisely tune its properties to manufacture flexible functional materials or miniaturized devices for electronic and biomedical applications. However, conventional lithographic techniques are cumbersome for scalable producing time- and cost-effective graphene patterns, thus greatly impeding their practical applications. Here we present a simple scalable fabrication of wafer-scale 3D graphene micropatterns by direct laser tuning expansion and reduction of graphene oxide using a standard LightScribe DVD burner...
April 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29625012/home-based-physical-activity-program-improves-depression-and-anxiety-in-older-adults
#7
Susan Aguiñaga, Diane K Ehlers, Elizabeth A Salerno, Jason Fanning, Robert W Motl, Edward McAuley
BACKGROUND: Late-life depression and anxiety among older adults is an important public health concern. This study examined the effect of a DVD-delivered exercise intervention on the secondary outcomes of depression and anxiety in older adults and the extent to which physical self-worth mediated the relationship between leisure-time physical activity and depression and anxiety. METHODS: Older adults (N = 307) were randomized to a 6-month flexibility, toning, and balance DVD (FlexToBa™, FTB) or healthy aging DVD control...
April 6, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29619284/yoga-for-young-adults-with-noncurative-cancer-a-brief-report
#8
Hillary Woodside, S Nicole Culos-Reed, Marie-Claude Grégoire, Robert Rutledge, Melanie R Keats
Background: The practice of yoga has been shown to improve disease- and treatment-related side effects in the noncurative cancer patient. Objective: This user experience study aimed to examine the feasibility and usefulness of a DVD-based yoga program for young adult cancer patients with a noncurative diagnosis. Methods: Participants were asked to partake in a 7-week DVD-based yoga program and complete measures of program use and usefulness...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29617366/cross-sectional-associations-of-screen-time-and-outdoor-play-with-social-skills-in-preschool-children
#9
Trina Hinkley, Helen Brown, Valerie Carson, Megan Teychenne
Screen time and physical activity behaviours develop during the crucial early childhood period (0-5 years) and impact multiple health and developmental outcomes, including psychosocial wellbeing. Social skills, one component of psychosocial wellbeing, are vital for children's school readiness and future mental health. This study investigates potential associations of screen time and outdoor play (as a proxy for physical activity) with social skills. Cross sectional data were available for 575 mothers with a child (54% boys) aged 2-5 years...
2018: PloS One
https://www.readbyqxmd.com/read/29602035/a-flexible-and-highly-sensitive-nonenzymatic-glucose-sensor-based-on-dvd-laser-scribed-graphene-substrate
#10
Songyue Lin, Wendou Feng, Xiaofei Miao, Xiangxin Zhang, Sujing Chen, Yuanqiang Chen, Wei Wang, Yining Zhang
Flexible and implantable glucose biosensors are emerging technologies for continuous monitoring of blood-glucose of diabetes. Developing a flexible conductive substrates with high active surface area is critical for advancing the technology. Here, we successfully fabricate a flexible and highly sensitive nonenzymatic glucose by using DVD-laser scribed graphene (LSG) as a flexible conductively substrate. Copper nanoparticles (Cu-NPs) are electrodeposited as the catalyst. The LSG/Cu-NPs sensor demonstrates excellent catalytic activity toward glucose oxidation and exhibits a linear glucose detection range from 1 μM to 4...
July 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29592882/abt-165-a-dual-variable-domain-immunoglobulin-dvd-ig-targeting-dll4-and-vegf-demonstrates-superior-efficacy-and-favorable-safety-profiles-in-preclinical-models
#11
Yingchun Li, Jonathan A Hickson, Dominic J Ambrosi, Deanna L Haasch, Kelly D Foster-Duke, Lucia J Eaton, Enrico L Digiammarino, Sanjay C Panchal, Fang Jiang, Sarah R Mudd, Catherine Zhang, Surekha S Akella, Wenqing Gao, Sherry L Ralston, Louie Naumovski, Jijie Gu, Susan E Morgan-Lappe
Anti-angiogenic therapy is a clinically validated modality in cancer treatment. To date, all approved anti-angiogenic drugs primarily inhibit the vascular endothelial growth factor (VEGF) pathway. Delta-like ligand 4 (DLL4) has been identified as a potential drug target in VEGF-independent angiogenesis and tumor initiating cell (TIC) survival. A dual-specific biologic targeting both VEGF and DLL4 could be an attractive strategy to improve the effectiveness of anti-VEGF therapy. ABT-165 was uniquely engineered using a proprietary dual-variable domain immunoglobulin (DVD-Ig) technology based on its ability to bind and inhibit both DLL4 and VEGF...
March 28, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29587673/a-randomised-controlled-trial-of-the-effectiveness-of-a-breastfeeding-training-dvd-on-improving-breastfeeding-knowledge-and-confidence-among-healthcare-professionals-in-china
#12
Yuan Ying Ma, Louise L Wallace, Li Qian Qiu, Joanna Kosmala-Anderson, Naomi Bartle
BACKGROUND: Despite almost all babies being breastfed initially, the exclusive breastfeeding rate at six months is less than 30% in China. Improving professionals' knowledge and practical skill is a key government strategy to increase breastfeeding rates. This study aimed to test the effectiveness of a breastfeeding DVD training method for clinicians on improving their knowledge and confidence in the breastfeeding support skills of teaching mothers Positioning and Attachment (P & A) and Hand Expression (HE)...
March 27, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29567176/direct-solid-phase-microextraction-combined-with-gas-chromatography-mass-spectrometry-for-the-determination-of-biogenic-amines-in-wine
#13
Myrsini Papageorgiou, Dimitra Lambropoulou, Calum Morrison, Jacek Namieśnik, Justyna Płotka-Wasylka
A direct method based on immersion solid phase microextraction (DI-SPME) gas chromatography mass-spectrometry (GC-MS) was optimized and validated for the determination of 16 biogenic amines in Polish wines. In the analysis two internal standards were used: 1,7-diaminoheptane and bis-3-aminopropylamine. The method allows for simultaneous extraction and derivatization, providing a simple and fast mode of extraction and enrichment. Different parameters which affect the extraction procedure were studied and optimized including ionic strength (0-25%), fiber materials (PDMS/DVB, PDMS/DVD + OC, Polyacrylate, Carboxen/PDMS and DVB/CAR/PDMS) and timings of the extraction, derivatization and desorption processes...
June 1, 2018: Talanta
https://www.readbyqxmd.com/read/29558977/sedentary-behavior-during-leisure-time-physical-activity-and-dietary-habits-as-risk-factors-of-overweight-among-school-children-aged-14-15-years-case-control-study
#14
Indrani Godakanda, Chrishantha Abeysena, Ayesha Lokubalasooriya
OBJECTIVE: To determine the risk of sedentary behavior during leisure time, physical activity and dietary habits on overweight among school children aged 14-15 years in Kalutara District, Sri Lanka. RESULTS: School based case-control study was conducted during September to November 2013 including 176 overweight children as cases and 704 children with normal weight as controls. Cases were defined as body mass index for age and sex of ≥ +1SD and controls as those in the range of -2SD to +1SD...
March 20, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29525217/completeness-of-human-papilloma-virus-vaccination-a-systematic-review
#15
REVIEW
Hee Sun Kang, Jennie C De Gagne, Ye Dong Son, Sun-Mi Chae
PROBLEM: It has been reported that some adolescents and young women who started taking human papillomavirus (HPV) vaccination are not completing all three doses. The aim of this study was to systematically review intervention studies on HPV vaccination completion. ELIGIBILITY CRITERIA: Intervention studies with a comparison group that assessed HPV vaccination completion rate as the primary outcome variable in adolescents and adults younger than 26years of age, and published in English from 2006 to 2016, were eligible for review...
March 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29514725/-all-of-a-sudden-a-lot-less-still-makes-it-worthwhile-to-be-alive-palliative-care-patients-views-on-life
#16
Vanessa Romotzky, Julia Strupp, Alexander Hayn, Jens Ulrich Rüffer, Judith Grümmer, Raymond Voltz
OBJECTIVE: We aimed to elucidate the views on life as narrated by patients in palliative care (PC) to find out what patients deem to be essential in their life, whether something has changed concerning their view of life in light of the disease, and whether interviewees would like to give others something to take with them. METHOD: Data were collected from narrative audio and video interviews with 18 inpatients in a specialized PC unit. Interviews were recorded and transcribed verbatim and analyzed using qualitative content analysis applying MAXQDA software...
March 8, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29504468/comparing-weight-loss-maintenance-outcomes-of-a-worksite-based-lifestyle-program-delivered-via-dvd-and-face-to-face-a-randomized-trial
#17
Claire Townsend Ing, Robin E S Miyamoto, Rui Fang, Mapuana Antonio, Diane Paloma, Kathryn L Braun, Joseph Keawe'aimoku Kaholokula
BACKGROUND: Native Hawaiians and other Pacific Islanders have high rates of overweight and obesity compared with other ethnic groups in Hawai'i. Effective weight loss and weight loss-maintenance programs are needed to address obesity and obesity-related health inequities for this group. AIMS: Compare the effectiveness of a 9-month, worksite-based, weight loss-maintenance intervention delivered via DVD versus face-to-face in continued weight reduction and weight loss maintenance beyond the initial weight loss phase...
March 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29500140/comparative-efficacy-of-treatments-for-previously-treated-multiple-myeloma-a-systematic-literature-review-and-network-meta-analysis
#18
REVIEW
Eric M Maiese, Claire Ainsworth, Jean-Gabriel Le Moine, Outi Ahdesmäki, Judith Bell, Emma Hawe
PURPOSE: New therapies, including daratumumab plus lenalidomide plus dexamethasone (DRd) and daratumumab plus bortezomib plus dexamethasone (DVd), have recently been approved in the United States for patients with multiple myeloma (MM) who have received at least 1 prior line of therapy. However, few treatments have been compared in head-to-head clinical trials to determine the most efficacious therapy. In an update of the POLLUX (Phase 3 Study Comparing DRd Versus Rd in Subjects with Relapsed or Refractory Multiple Myeloma [RRMM]) trial, median progression-free survival (PFS) for DRd was not reached; the hazard ratio compared with Rd was 0...
March 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29454818/comprehensive-characterization-of-printed-circuit-boards-of-various-end-of-life-electrical-and-electronic-equipment-for-beneficiation-investigation
#19
Anshu Priya, Subrata Hait
Comprehensive characterization of printed circuit board (PCB) of end-of-life electrical and electronic equipment (EEE) is obligatory for prospective profitable beneficiation. In this study, beneficiation oriented comprehensive characterization of two brands of PCBs each of 16 end-of-life EEE was conducted in terms of their physicochemical characteristics with special emphasis on the content of 16 general elements, 2 precious metals and 15 rare earth elements (REEs). General elements and their highest weight percent composition found in different PCBs of the EEEs were Cu (23% in laptop), Al (6% in computer), Pb (15% in DVD player) and Ba (7% in TV)...
May 2018: Waste Management
https://www.readbyqxmd.com/read/29436224/dynamic-stocks-and-flows-analysis-of-bisphenol-a-bpa-in-china-2000-2014
#20
Daqian Jiang, Wei-Qiang Chen, Xianlai Zeng, Linbin Tang
Bisphenol A (BPA), a synthetic organic chemical, is creating a new category of ecological and human health challenges due to unintended leakage. Effectively managing the use and leakage of BPA can benefit from an understanding of the anthropogenic BPA cycles (i.e., the size of BPA flows and stocks). In this work, we provide a dynamic analysis of the anthropogenic BPA cycles in China for 2000-2014. We find that China's BPA consumption has increased 10-fold since 2000, to ∼3 million tonnes/year. With the increasing consumption, China's in-use BPA stock has increased 500-fold to 14...
March 20, 2018: Environmental Science & Technology
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