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Zhizhen Chen, Liping Wang, Tianshu Xu, Qifei Wang, Lishan Kang, Qi Zhao
Bispecific antibodies with binding specificities for two different antigens have prompted a lot of interest into their development and application. Currently, more than ten bispecific antibodies have been clinically validated for the treatment of various diseases, including cancers and inflammatory diseases. Intensive studies in antibody engineering drive the generation of different bispecific antibody formats that differ in size and shape. However, the most prominent formats, such as IgG-single-chain (sc) Fv or dual-variable domain (DVD) IgG, deviating from the natural IgG structure, may lead to manufacturing difficulties or increase the potential risk of immunogenicity...
October 18, 2016: Current Pharmaceutical Biotechnology
Susann Weihrauch-Blüher, Stefanie Koormann, Jana Brauchmann, Susanna Wiegand
BACKGROUND: The increasing prevalence of childhood obesity is - amongst other factors - due to changed leisure time habits with decreased physical activity and increased media consumption. However, electronic media such as tablets and smartphones might also provide a novel intervention approach to prevent obesity in childhood and adolescence. OBJECTIVES: A summary of interventions applying electronic media to prevent childhood obesity is provided to investigate short term effects as well as long term results of these interventions...
October 18, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Stephanie Schoeppe, Corneel Vandelanotte, Elling Bere, Nanna Lien, Maïté Verloigne, Éva Kovács, Yannis Manios, Mona Bjelland, Frøydis Nordgård Vik, Wendy Van Lippevelde
BACKGROUND: Parents play an important role in modelling healthy behaviours to their children. This study investigated associations between parent and child physical activity and screen time behaviours across specific domains, including moderating effects by parent and child gender. METHOD: The sample comprised 3300 school children and 2933 parents participating in the UP4FUN project (mean ages: child 11.2 ± 0.8 years, mother 40.0 ± 4.9 years, father 43.4 ± 5...
October 15, 2016: European Journal of Public Health
Yoko Fujimaki, Koichi Tsunoda, Rika Kobayashi, Chong Tonghyo, Fujinobu Tanaka, Hiroyuki Kuroda, Tsutomu Numata, Toyota Ishii, Reiko Kuroda, Sawako Masuda, Sho Hashimoto, Hayato Misawa, Naoko Shindo, Takahiro Mori, Hiroko Mori, Naoki Uchiyama, Yuichirou Kamei, Masashi Tanaka, Hironobu Hamaya, Shingo Funatsuki, Satoko Usui, Ikuno Ito, Kohei Hamada, Akihito Shindo, Yutaka Tokumaru, Yoko Morita, Rumi Ueha, Takaharu Nito, Shu Kikuta, Sotaro Sekimoto, Kenji Kondo, Takashi Sakamoto, Kenji Itoh, Tatsuya Yamasoba, Sumio Matsumoto
OBJECTIVES: To evaluate the effect of a self-controlled vocal exercise in elderly people with glottal closure insufficiency. DESIGN: Parallel-arm, individual randomized controlled trial. METHODS: Patients who visited one of 10 medical centers under the National Hospital Organization group in Japan for the first time, aged 60 years or older, complaining of aspiration or hoarseness, and endoscopically confirmed to have glottal closure insufficiency owing to vocal cord atrophy, were enrolled in this study...
October 14, 2016: Clinical Rehabilitation
Giulio Rosati, Matteo Scaramuzza, Elisabetta Pasqualotto, Alessandro De Toni, Carlo Reggiani, Alessandro Paccagnella
In this work, we demonstrate how an innovative, out-of-cleanroom customized CD/DVD fabrication process can be successfully used for mass production of biosensors with thin-film electrodes. We show that silver and gold electrodes can be used for impedimetric and voltammetric biosensing applications, both in presence and absence of a redox mediator. We modeled the redox/non-redox electrodes impedance through equivalent electrical circuits, and we evaluated their transfer function sensitivity with a one-factor-at-a-time approach...
October 10, 2016: IEEE Transactions on Nanobioscience
Samuel Weng, Xiaochun Li, Yunchao Li, Hua-Zhong Yu
Beyond their essential applications in portable data storage for the past 30 years, optical discs and corresponding recording/reading technologies have been extensively explored with the ultimate goal of creating novel analytical tools for on-site chemical analysis and point-of-care (POC) medical diagnosis. In particular, the disc media (CD, DVD, and BD) are proven to be inexpensive and versatile substrate materials for the preparation of various biochips and microfluidic systems; conventional computer drives and disc players are widely adapted for biochip signal reading and microscopic imaging...
September 27, 2016: Analyst
Michael E Hyland, David Mg Halpin, Sue Blake, Clare Seamark, Margaret Pinnuck, David Ward, Ben Whalley, Colin J Greaves, Adam L Hawkins, Dave Seamark
BACKGROUND: A review of the effectiveness of relaxation techniques for chronic obstructive pulmonary disease patients has shown inconsistent results, but studies have varied in terms of technique and outcome measures. AIM: To determine patient preference for different relaxation techniques. METHODS: Chronic obstructive pulmonary disease patients were presented with six techniques via a DVD and asked to rate the techniques in terms of effectiveness, rank in order of likely use, and comment...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Wendy Chaboyer, Tracey Bucknall, Joan Webster, Elizabeth McInnes, Brigid M Gillespie, Merrilyn Banks, Jennifer A Whitty, Lukman Thalib, Shelley Roberts, Mandy Tallott, Nicky Cullum, Marianne Wallis
BACKGROUND: Hospital-acquired pressure ulcers are a serious patient safety concern, associated with poor patient outcomes and high healthcare costs. They are also viewed as an indicator of nursing care quality. OBJECTIVE: To evaluate the effectiveness of a pressure ulcer prevention care bundle in preventing hospital-acquired pressure ulcers among at risk patients. DESIGN: Pragmatic cluster randomised trial. SETTING: Eight tertiary referral hospitals with >200 beds each in three Australian states...
September 23, 2016: International Journal of Nursing Studies
Julie Chartrand, Jocelyne Tourigny, Johnna Maccormick
AIMS: To examine the effect of a pre-operative DVD on parents' knowledge, participation and anxiety and on children's distress, pain, analgesic requirements and length of recovery after same-day surgery. BACKGROUND: Very few parents are adequately prepared to participate in their child's care at the time of a same-day surgery. An educational DVD was developed to educate parents on how to actively support their child in the recovery room. DESIGN: Single-blind, post-test randomized controlled trial...
September 28, 2016: Journal of Advanced Nursing
Sonia A Duffy, David L Ronis, Carrie A Karvonen-Gutierrez, Lee A Ewing, Stephanie V Hall, James J Yang, Patricia L Thomas, Christine M Olree, Kimberly A Maguire, Lisa Friedman, Donna Gray, Neil Jordan
INTRODUCTION: This study determined the effectiveness of the Tobacco Tactics intervention. DESIGN/SETTING/PARTICIPANTS: This was a pragmatic, quasi-experimental study conducted from 2010 to 2013 and analyzed from 2014 to 2015 in five Michigan community hospitals; three received the Tobacco Tactics intervention, and two received usual care. Smokers (N=1,528) were identified during hospitalization, and sent surveys and cotinine tests after 6 months. Changes in pre- to post-intervention quit rates in the intervention sites were compared with usual care control sites...
October 2016: American Journal of Preventive Medicine
Rachel Forster Held, Susan Santos, Michelle Marki, Drew Helmer
BACKGROUND: We developed and disseminated an educational DVD to introduce U.S. Veterans to independently-practiced complementary and alternative medicine (CAM) techniques and encourage CAM experimentation. The project's goal was to determine optimal dissemination methods to facilitate implementation within the Veteran's Health Administration. METHODS: In the first phase, the DVD was disseminated using four methods: passive, provider-mediated, active, and peer-mediated...
2016: BMC Complementary and Alternative Medicine
Ming-Ju Hsieh, Farhan Bhanji, Wen-Chu Chiang, Chih-Wei Yang, Kuo-Liong Chien, Matthew Huei-Ming Ma
AIM: The efficacy of learning basic life support (BLS) through self-instruction is not clearly understood. The aim of our review was to compare the effect of self-instruction with that of traditional instruction on learners taking BLS courses. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, PsycInfo and SCI-EXPANDED databases for randomized control trials (RCTs) or randomized cluster-controlled trials published from January 1, 1966 to April 25, 2015 which compared self-instruction with traditional instruction in BLS courses...
August 28, 2016: Resuscitation
Caroline Frot, Nicolas Taccoen, Charles N Baroud
The maker movement has shown how off-the-shelf devices can be combined to perform operations that, until recently, required expensive specialized equipment. Applying this philosophy to microfluidic devices can play a fundamental role in disseminating these technologies outside specialist labs and into industrial use. Here we show how nanoliter droplets can be manipulated using a commercial DVD writer, interfaced with an Arduino electronic controller. We couple the optical setup with a droplet generation and manipulation device based on the "confinement gradients" approach...
2016: PloS One
Philip J Wiffen
The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online ( ). The April 2016 issue (2nd DVD for 2016) contains 6875 complete reviews, 2417 protocols for reviews in production, and 36,600 short summaries of systematic reviews published in the general medical literature (this short summary database is no longer being updated). In addition, there are citations of 934,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register...
September 2016: Journal of Pain & Palliative Care Pharmacotherapy
C Saldanha-Gomes, B Heude, M-A Charles, B de Lauzon-Guillain, J Botton, S Carles, A Forhan, P Dargent-Molina, S Lioret
Background/ObjectivesSedentary behavior, physical activity and dietary behavior are formed early during childhood and tend to remain relatively stable into later life. No longitudinal studies have assessed the independent influence of these three energy balance-related behaviors during toddlerhood on later adiposity. We aimed to analyze the associations between TV/DVD watching time, outdoor play time, and dietary patterns at age 2 years and child adiposity at age 5, in boys and girls separately.Subjects/MethodsThis study included 883 children from the French EDEN mother-child cohort...
August 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Margaret Haigh, Shaouli Shahid, Kathleen O'Connor, Sandra C Thompson
OBJECTIVE: To examine a) the implementation and use of a DVD developed to educate Aboriginal people about bowel cancer and bowel cancer screening; and b) broader aspects of Aboriginal participation in the National Bowel Cancer Screening Program. METHODS: Qualitative methods and descriptive approaches were used. Data were collected using face-to-face and telephone interviews and focus group discussions. There were 67 participants, including those involved in the development and distribution of the DVD, health professionals and Aboriginal community members...
August 14, 2016: Australian and New Zealand Journal of Public Health
Marie Bakitas, J Nicholas Dionne-Odom, Lisa Jackson, Jennifer Frost, Margaret F Bishop, Zhongze Li
OBJECTIVE: Few decision aids are available for patients with a serious illness who face many treatment and end-of-life decisions. We evaluated the Looking Ahead: Choices for Medical Care When You're Seriously Ill® patient decision aid (PtDA), one component of an early palliative care clinical trial. METHOD: Our participants included individuals with advanced cancer and their caregivers who had participated in the ENABLE (Educate, Nurture, Advise, Before Life Ends) early palliative care telehealth randomized controlled trial (RCT) conducted in a National Cancer Institute-designated cancer center, a U...
August 12, 2016: Palliative & Supportive Care
Eakta Jain, Yaser Sheikh, Jessica Hodgins
Comic art consists of a sequence of panels of different shapes and sizes that visually communicate the narrative to the reader. The move-on-stills technique allows such still images to be retargeted for digital displays via camera moves. Today, moves-on-stills can be created by software applications given user-provided parameters for each desired camera move. The proposed algorithm uses viewer gaze as input to computationally predict camera move parameters. The authors demonstrate their algorithm on various comic book panels and evaluate its performance by comparing their results with a professional DVD...
July 2016: IEEE Computer Graphics and Applications
Keitly Mensah, Aurélia Maire, Jean-Michel Oppert, Julien Dugas, Hélène Charreire, Christiane Weber, Chantal Simon, Julie-Anne Nazare
BACKGROUND: Comprehensive assessment of sedentary behavior (SB) and physical activity (PA), including transport-related activities (TRA), is required to design innovative PA promotion strategies. There are few validated instruments that simultaneously assess the different components of human movement according to their context of practice (e.g. work, transport, leisure). We examined test-retest reliability and validity of the Sedentary, Transportation and Activity Questionnaire (STAQ), a newly developed questionnaire dedicated to assessing context-specific SB, TRA and PA...
2016: BMC Public Health
Lauren R Meltzer, Cathy D Meade, Diana B Diaz, Monica S Carrington, Thomas H Brandon, Paul B Jacobsen, Judith C McCaffrey, Eric B Haura, Vani N Simmons
We describe the series of iterative steps used to develop a smoking relapse-prevention intervention customized to the needs of cancer patients. Informed by relevant literature and a series of preliminary studies, an educational tool (DVD) was developed to target the unique smoking relapse risk factors among cancer patients. Learner verification interviews were conducted with 10 cancer patients who recently quit smoking to elicit feedback and inform the development of the DVD. The DVD was then refined using iterative processes and feedback from the learner verification interviews...
August 1, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
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