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https://www.readbyqxmd.com/read/28628479/chronic-pain-in-high-school-students-is-associated-with-physical-activity-and-sleeping-hours-but-not-with-screen-time
#1
Anabela G Silva, Pedro Sá Couto, Alexandra Queirós, Maritza Neto, Nelson P Rocha
Background Existing studies on the association between physical activity (PA), screen based time and sleeping show conflicting results. Objective This study investigates the association between chronic pain at different body regions and self-reported PA, screen based time and sleeping hours in high school students. Subjects A total of 969 students aged 13-19 years old. Methods Participants completed a questionnaire on chronic pain, time spent in moderate and vigorous PA, screen based time watching televivsion (TV)/digital versatile discs (DVD), playing, using mobile phones and computers and sleeping hours...
June 17, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28602711/patients-perceptions-and-attitudes-on-recurrent-prostate-cancer-and-hormone-therapy-qualitative-comparison-between-decision-aid-and-control-groups
#2
Rita Gorawara-Bhat, Siobhan O'Muircheartaigh, Supriya Mohile, William Dale
OBJECTIVE: To compare patients' attitudes towards recurrent prostate cancer (PCa) and starting hormone therapy (HT) treatment in two groups-Decision-Aid (DA) (intervention) and Standard-of-care (SoC) (Control). METHODS: The present research was conducted at three academic clinics-two in the Midwest and one in the Northeast U.S. Patients with biochemical recurrence of PCa (n=26) and follow-up oncology visits meeting inclusion criteria were randomized to either the SoC or DA intervention group prior to their consultation...
June 8, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28585177/potent-and-conditional-redirected-t-cell-killing-of-tumor-cells-using-half-dvd-ig
#3
Philip D Bardwell, Matthew M Staron, Junjian Liu, Qingfeng Tao, Susanne Scesney, Gail Bukofzer, Luis E Rodriguez, Chee-Ho Choi, Jennifer Wang, Qing Chang, Feng Dong, Cherrie Donawho, Jieyi Wang, Christine M Grinnell, Edit Tarcsa, Charles Hutchins, Tariq Ghayur, Jijie Gu
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biology. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties...
June 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28555270/critical-review-of-brain-avm-surgery-surgical-results-and-natural-history-in-2017
#4
REVIEW
Michael Kerin Morgan, Andrew Stewart Davidson, Nazih N A Assaad, Marcus Andrew Stoodley
BACKGROUND: An understanding of the present standing of surgery, surgical results and the role in altering the future morbidity and mortality of untreated brain arteriovenous malformations (bAVMs) is appropriate considering the myriad alternative management pathways (including radiosurgery, embolization or some combination of treatments), varying risks and selection biases that have contributed to confusion regarding management. The purpose of this review is to clarify the link between the incidence of adverse outcomes that are reported from a management pathway of either surgery or no intervention with the projected risks of surgery or no intervention...
May 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28547942/evaluation-of-a-skin-self-examination-programme-a-four-stage-recursive-model
#5
David Rowell, Kim Huong Nguyen, Peter Baade, Monika Janda
Background: Effective skin self-examination can enable early diagnosis and treatment of skin cancer, which otherwise could result in significant morbidity and mortality. We compare the effects of watching a DVD and reading printed materials on self skin examination. Methods: Longitudinal data from the Randomized Skin Awareness Trial were analysed (n=984). The control group were provided with written materials describing how to conduct effective skin self-examination. The intervention group received additional instruction from a DVD...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28531788/association-of-dietary-factors-with-severity-of-coronary-artery-disease
#6
Namita Mahalle, M K Garg, S S Naik, M V Kulkarni
BACKGROUND: Cardiovascular disease has taken epidemic proportions during past decades. Cardiovascular risk factors contribute to progression of coronary lesions, worsening the patient's prognosis. This study was planned to analyze the association of dietary factors with severity of coronary artery disease (CAD) in Indian patients. METHODS: Three hundred patients with known coronary disease above the age of 25 years were included in this study. Blood samples were collected for biochemical markers...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28521606/can-video-self-modeling-improve-affected-limb-reach-and-grasp-ability-in-stroke-patients
#7
Kylie Ann Steel, Kurt Mudie, Remi Sandoval, David Anderson, Sera Dogramaci, Mohammad Rehmanjan, Ingvars Birznieks
The authors examined whether feedforward video self-modeling (FF VSM) would improve control over the affected limb, movement self-confidence, movement self-consciousness, and well-being in 18 stroke survivors. Participants completed a cup transport task and 2 questionnaires related to psychological processes pre- and postintervention. Pretest video footage of the unaffected limb performing the task was edited to create a best-of or mirror-reversed training DVD, creating the illusion that patients were performing proficiently with the affected limb...
May 19, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28511650/pain-pain-intensity-and-pain-disability-in-high-school-students-are-differently-associated-with-physical-activity-screening-hours-and-sleep
#8
Anabela G Silva, Pedro Sa-Couto, Alexandra Queirós, Maritza Neto, Nelson P Rocha
BACKGROUND: Studies exploring the association between physical activity, screen time and sleep and pain usually focus on a limited number of painful body sites. Nevertheless, pain at different body sites is likely to be of different nature. Therefore, this study aims to explore and compare the association between time spent in self-reported physical activity, in screen based activities and sleeping and i) pain presence in the last 7-days for 9 different body sites; ii) pain intensity at 9 different body sites and iii) global disability...
May 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28510770/inferior-oblique-overaction-anterior-transposition-versus-myectomy
#9
Zhale Rajavi, Mohadeseh Feizi, Narges Behradfar, Mehdi Yaseri, Shima Sayanjali, Tahmine Motevaseli, Hamideh Sabbaghi, Mohammad Faghihi
PURPOSE: To compare the efficacy of inferior oblique myectomy and anterior transposition for correcting inferior oblique overaction (IOOA). METHODS: This retrospective study was conducted on 56 patients with IOOA who had either myectomy or anterior transposition of the inferior oblique muscle from 2010 to 2015. The authors compared preoperative and postoperative inferior oblique muscle function grading (-4 to +4) as the main outcome measure and vertical and horizontal deviation, dissociated vertical deviation (DVD), and A- and V-pattern between the two surgical groups as secondary outcomes...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28499843/magnetic-resonance-imaging-in-dissociated-strabismus-complex-demonstrates-generalized-hypertrophy-of-rectus-extraocular-muscles
#10
Ghada Z Rajab, Soh Youn Suh, Joseph L Demer
BACKGROUND: Dissociated strabismus complex (DSC) is an enigmatic form of strabismus that includes dissociated vertical deviation (DVD) and dissociated horizontal deviation (DHD). We employed magnetic resonance imaging (MRI) to evaluate the extraocular muscles in DSC. METHODS: We studied 5 patients with DSC and mean age of 25 years (range, 12-42 years), and 15 age-matched, orthotropic control subjects. All patients had DVD; 4 also had DHD. We employed high-resolution, surface coil MRI with thin, 2 mm slices and central target fixation...
May 9, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28449637/the-effect-of-a-dynamic-chair-on-seated-energy-expenditure
#11
Aoife Synnott, Wim Dankaerts, Jan Seghers, Helen Purtill, Kieran O'Sullivan
Dynamic sitting approaches have been advocated to increase seated energy expenditure with the view of lessening the sedentary nature of the task. This study compared energy expenditure (EE) and overall body discomfort on a novel dynamic chair with a standard office chair. Fifteen pain-free participants completed a DVD viewing task on both chairs in a randomised order. Energy expenditure and discomfort were collected simultaneously. Linear mixed models were used to analyse steady-state EE recorded on each of the chairs...
May 5, 2017: Ergonomics
https://www.readbyqxmd.com/read/28445854/balance-training-in-individuals-with-parkinson-s-disease-therapist-supervised-vs-home-based-exercise-programme
#12
Elizabeth Maria Atterbury, Karen Estelle Welman
BACKGROUND: Poor locomotion and balance in Parkinson's disease (PD) often diminishes independence. Accordingly, gait is considered one of the most relevant rehabilitation outcomes, and home-based balance exercises might be a viable mode of exercise delivery for individuals with PD. However, research on PD interventions rarely indicate best practices to deliver exercises. Therefore, this study endeavoured to compare the efficacy of a home-based and therapist-supervised balance programme on gait parameters, dynamic balance, balance confidence and motivation in individuals diagnosed with PD...
April 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28414169/a-biomechanical-investigation-of-different-screw-head-designs-for-vertebral-derotation-in-scoliosis-surgery
#13
Po-Yi Liu, Po-Liang Lai, Chun-Li Lin
BACKGROUND CONTEXT: The posterior pedicle screw-rod system, which is widely used to correct spinal deformities, achieves a good correction rate in the frontal and coronal planes but not in the axial plane. Direct vertebral derotation (DVD) was developed to correct axial plane deformities. However, the design of screw head and body connection, in terms of monoaxial, polyaxial, and uniplanar screw, may influence the efficiency of DVD. PURPOSE: This study compared the efficiency of a newly designed uniplanar screw with that of monoaxial and polyaxial screws in the DVD maneuver...
April 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28408872/social-interaction-affects-neural-outcomes-of-sign-language-learning-as-a-foreign-language-in-adults
#14
Noriaki Yusa, Jungho Kim, Masatoshi Koizumi, Motoaki Sugiura, Ryuta Kawashima
Children naturally acquire a language in social contexts where they interact with their caregivers. Indeed, research shows that social interaction facilitates lexical and phonological development at the early stages of child language acquisition. It is not clear, however, whether the relationship between social interaction and learning applies to adult second language acquisition of syntactic rules. Does learning second language syntactic rules through social interactions with a native speaker or without such interactions impact behavior and the brain? The current study aims to answer this question...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28380053/effect-and-process-evaluation-of-a-kindergarten-based-family-involved-intervention-with-a-randomized-cluster-design-on-sedentary-behaviour-in-4-to-6-year-old-european-preschool-children-the-toybox-study
#15
Julie Latomme, Greet Cardon, Ilse De Bourdeaudhuij, Violeta Iotova, Berthold Koletzko, Piotr Socha, Luis Moreno, Odysseas Androutsos, Yannis Manios, Marieke De Craemer
BACKGROUND: The aim of the present study evaluated the effect and process of the ToyBox-intervention on proxy-reported sedentary behaviours in 4- to 6-year-old preschoolers from six European countries. METHODS: In total, 2434 preschoolers' parents/primary caregivers (mean age: 4.7±0.4 years, 52.2% boys) filled out a questionnaire, assessing preschoolers' sedentary behaviours (TV/DVD/video viewing, computer/video games use and quiet play) on weekdays and weekend days...
2017: PloS One
https://www.readbyqxmd.com/read/28375048/arabinosylation-of-recombinant-human-immunoglobulin-based-protein-therapeutics
#16
Patrick Hossler, Christopher Chumsae, Christopher Racicot, David Ouellette, Alexander Ibraghimov, Daniel Serna, Alessandro Mora, Sean McDermott, Boris Labkovsky, Susanne Scesney, Christine Grinnell, Gregory Preston, Sahana Bose, Ralf Carrillo
Protein glycosylation is arguably the paramount post-translational modification on recombinant glycoproteins, and highly cited in the literature for affecting the physiochemical properties and the efficacy of recombinant glycoprotein therapeutics. Glycosylation of human immunoglobulins follows a reasonably well-understood metabolic pathway, which gives rise to a diverse range of asparagine-linked (N-linked), or serine/threonine-linked (O-linked) glycans. In N-linked glycans, fucose levels have been shown to have an inverse relationship with the degree of antibody-dependent cell-mediated cytotoxicity, and high mannose levels have been implicated in potentially increasing immunogenicity and contributing to less favorable pharmacokinetic profiles...
May 2017: MAbs
https://www.readbyqxmd.com/read/28367042/a-valid-indication-and-the-effect-of-bilateral-inferior-oblique-transposition-on-recurrent-or-consecutive-horizontal-deviation-in-infantile-strabismus
#17
Suk-Gyu Ha, Gun-Hoo Na, Seung-Hyun Kim
PURPOSE: To evaluate the effects of bilateral inferior oblique transposition (BIOT) on horizontal deviation from primary position among patients with bilateral dissociated vertical deviation (DVD) associated with inferior oblique overaction (IOOA) in infantile strabismus. METHODS: Retrospective chart review was conducted among 19 patients with infantile strabismus. All patients had DVD and IOOA with consecutive or recurrent horizontal deviation and underwent modified BIOT surgery...
April 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28365874/developmental-vitamin-d-dvd-deficiency-reduces-nurr1-and-th-expression-in-post-mitotic-dopamine-neurons-in-rat-mesencephalon
#18
Wei Luan, Luke Alexander Hammond, Edmund Cotter, Geoffrey William Osborne, Suzanne Adele Alexander, Virginia Nink, Xiaoying Cui, Darryl Walter Eyles
Developmental vitamin D (DVD) deficiency has been proposed as an important risk factor for schizophrenia. Our previous study using Sprague Dawley rats found that DVD deficiency disrupted the ontogeny of mesencephalic dopamine neurons by decreasing the mRNA level of a crucial differentiation factor of dopamine cells, the nuclear receptor related 1 protein (Nurr1). However, it remains unknown whether this reflects a reduction in dopamine cell number or in Nurr1 expression. It is also unclear if any particular subset of developing dopamine neurons in the mesencephalon is selectively affected...
April 1, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28362053/to-what-extent-may-botulinum-toxin-type-a-injections-be-an-alternative-choice-to-surgery-in-infantile-esotropia
#19
Claude Speeg-Schatz, Paul Burgun, Sylvaine Gottenkiene
INTRODUCTION: Evaluation of a single injection of botulinum toxin A in infantile esotropia as an alternative choice to surgery in a retrospective cases serie. METHODS: Patients (65 consecutive children aged 9 to 26 months with infantile strabismus) underwent botulinum toxin A injection in both medial recti Botulinum toxin A injection. Clinical datas including measurement of angle of deviation before and after injection. visual acuity, stereoscopy and side effects were observed in a 24 months period of follow-up...
May 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28359710/national-institutes-of-health-stroke-scale-in-plain-english-is-reliable-for-novice-nurse-users-with-minimal-training
#20
Sandy Dancer, Allen J Brown, Lisa Rietz Yanase
The National Institutes of Health Stroke Scale (NIHSS) is commonly used in Comprehensive Stroke Centers, but it has not been easily implemented in smaller centers. The aim of this study was to assess whether nurse providers who were naive to stroke assessment scales could obtain accurate stroke severity scores using our previously validated NIH Stroke Scale in Plain English (NIHSS-PE) with minimal or no training. METHODS: We randomly assigned 122 nursing students who were naive to stroke assessment scales to 1 of 4 groups: trained on the NIHSS, untrained on the NIHSS, trained on the NIHSS-PE, or untrained on the NIHSS-PE...
March 28, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
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