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Liver stereotactic

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https://www.readbyqxmd.com/read/29029891/imaging-findings-within-the-first-12%C3%A2-months-of-hepatocellular-carcinoma-treated-with-stereotactic-body-radiation-therapy
#1
Mishal Mendiratta-Lala, Everett Gu, Dawn Owen, Kyle C Cuneo, Latifa Bazzi, Theodore S Lawrence, Hero K Hussain, Matthew S Davenport
PURPOSE: To correlate the imaging findings of treated hepatocellular carcinoma (HCC) after stereotactic body radiation therapy (SBRT) with explant pathology and alpha-fetoprotein (AFP) response. METHODS AND MATERIALS: From 2007 to 2015, of 146 patients treated with liver SBRT for Barcelona Clinic Liver Cancer stage A hepatocellular carcinoma, 10 were identified with inclusion criteria and had regular interval follow-up magnetic resonance imaging/triple phase computed tomography and explant pathology or declining AFP values for radiology-pathology response correlation...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28994665/combining-deep-learning-with-anatomy-analysis-for-segmentation-of-portal-vein-for-liver-sbrt-planning
#2
Bulat Ibragimov, Diego Toesca, Daniel Chang, Albert Koong, Lei Xing
Automated segmentation of portal vein (PV) for liver radiotherapy planning is a challenging task due to potentially low vasculature contrast, complex PV anatomy and image artifacts originated from fiducial markers and vasculature stents. In this paper, we propose a novel framework for automated PV segmentation from computed tomography (CT) images. We apply convolutional neural networks (CNN) to learn consistent appearance patterns of PV using a training set of CT images with reference annotations and then enhance PV in previously unseen CT images...
October 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28975835/role-and-future-directions-of-external-beam-radiotherapy-for-primary-liver-cancer
#3
Florence K Keane, Theodore S Hong
The incidence of primary liver cancers continues to increase in the United States and worldwide. The majority of patients with primary liver cancer are not candidates for curative therapies such as surgical resection or orthotopic liver transplantation due to tumor size, vascular invasion, or underlying comorbidities. Therefore, while primary liver cancer is the sixth-most common cancer diagnosis worldwide, it represents the second leading cause of cancer-related deaths. Radiotherapy traditionally played a limited role in the treatment of primary liver cancer due to concerns over hepatic tolerance and the inability to deliver a tumoricidal dose of radiotherapy while still sparing normal hepatic parenchyma...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28975831/stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#4
Puja S Venkat, Sarah E Hoffe, Jessica M Frakes
The role of external beam radiation therapy for primary liver malignancies has historically been limited due to the risk of radiation-induced liver disease. However, with the advent of stereotactic body radiotherapy (SBRT), we are able to dose escalate while safely sparing critical nearby structures. This review explores the evidence surrounding the use of SBRT for the treatment of primary liver malignancies. A review of the literature was performed. This article discusses the challenges, efficacy, and safety of SBRT for primary liver malignancies in order to conceptualize its role within a multidisciplinary framework...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28954285/phase-ii-study-of-proton-based-stereotactic-body-radiation-therapy-for-liver-metastases-importance-of-tumor-genotype
#5
Theodore S Hong, Jennifer Y Wo, Darrell R Borger, Beow Y Yeap, Erin I McDonnell, Henning Willers, Lawrence S Blaszkowsky, Eunice L Kwak, Jill N Allen, Jeffrey W Clark, Shyam Tanguturi, Lipika Goyal, Janet E Murphy, John A Wolfgang, Lorraine C Drapek, Ronald S Arellano, Harvey J Mamon, John T Mullen, Kenneth K Tanabe, Cristina R Ferrone, David P Ryan, A John Iafrate, Thomas F DeLaney, Andrew X Zhu
Background: We evaluated the efficacy and safety of risk-adapted, proton-based stereotactic body radiation therapy (SBRT) for liver metastases from solid tumors. Methods: This single-arm phase II single institutional study (NCT01239381) included patients with limited extrahepatic disease, 800 mL or greater of uninvolved liver, and no cirrhosis or Child-Pugh A, who had received proton-based SBRT to one to four liver metastases from solid tumors. Treatment comprised 30 to 50 Gray equivalent (GyE) in five fractions based on the effective volume of liver irradiated...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28951010/spatiotemporal-fractionation-schemes-for-liver-stereotactic-body-radiotherapy
#6
Jan Unkelbach, Dávid Papp, Melissa R Gaddy, Nicolaus Andratschke, Theodore Hong, Matthias Guckenberger
BACKGROUND AND PURPOSE: Dose prescription in stereotactic body radiotherapy (SBRT) for liver tumors is often limited by the mean liver dose. We explore the concept of spatiotemporal fractionation as an approach to facilitate further dose escalation in liver SBRT. MATERIALS AND METHODS: Spatiotemporal fractionation schemes aim at partial hypofractionation in the tumor along with near-uniform fractionation in normal tissues. This is achieved by delivering distinct dose distributions in different fractions, which are designed such that each fraction delivers a high single fraction dose to complementary parts of the tumor while creating a similar dose bath in the surrounding noninvolved liver...
September 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28943046/radical-radiation-therapy-for-oligometastatic-breast-cancer-results-of-a-prospective-phase-ii-trial
#7
Marco Trovo, Carlo Furlan, Jerry Polesel, Francesco Fiorica, Stefano Arcangeli, Niccolò Giaj-Levra, Filippo Alongi, Alessandro Del Conte, Loredana Militello, Elena Muraro, Debora Martorelli, Simon Spazzapan, Massimiliano Berretta
BACKGROUND AND PURPOSE: We conducted a prospective phase II multicentric trial to determine if radical radiation therapy to all metastatic sites might improve the progression-free survival (PFS) in oligometastatic breast cancer patients. Secondary endpoints were local control (LC), overall survival (OS) and toxicity. METHODS AND MATERIALS: Inclusion criteria were the following: oligometastatic breast cancer with ≤5 metastatic sites, FDG-PET/CT staging, no brain metastases, primary tumor controlled...
September 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28920500/acute-toxicity-of-the-bowel-after-stereotactic-robotic-radiotherapy-for-abdominopelvic-oligometastases
#8
Michael Frelinghuysen, Wilco Schillemans, Lieke Hol, Cornelis Verhoef, Mischa Hoogeman, Joost Jan Nuyttens
AIM: To correlate dose-volume histogram (DVH) parameters with appearance of grade ≥2 acute and late gastrointestinal toxicity of stereotactic body radiotherapy (SBRT) in patients with abdominopelvic solitary or oligometastatic disease outside the liver. MATERIAL AND METHODS: Acute and late bowel toxicity of 84 abdominopelvic oligometastatic patients was registered. A logistic regression was performed between different DVH parameters and presence of grade ≥2 acute and late toxicity...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28917253/re-irradiation-with-stereotactic-body-radiation-therapy-sbrt
#9
Morten Høyer
Stereotactic body radiation therapy (SBRT) is a potential treatment option for patients who develop a relapse within or marginal to a previously irradiated volume, but it seems underused because of sparse knowledge on the efficacy and morbidity related to the treatment. Normal tissues often recover some of the damage caused by the primary radiotherapy with time, but the kinetics of recovery is not clearly described in the literature. There is a growing number of publications on SBRT reirradiation, but the literature consists mainly of retrospective cohort studies...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917251/advances-in-external-beam-stereotactic-body-radiotherapy-principle-concerns-in-implementing-a-liver-radiation-program
#10
Stewart Gaede, Michael I Lock
Despite significant advances in diagnosis, surgery and medical oncology, patients with primary and secondary liver cancer have some of the worst prognoses in oncology. In addition, the incidence of liver cancer is expected to increase. For this reason, centres are seeking new treatments and establishing specialized multidisciplinary teams. This article will focus on the evidence and practical data to assist in setting up or improving current process pathways, to provide an efficient and safe radiotherapy program for liver...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#11
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917249/challenges-in-imaging-assessment-following-liver-stereotactic-body-radiotherapy-pitfalls-to-avoid-in-clinical-practice
#12
Connie Yip, Gary J R Cook, Kasia Owczarczyk, Vicky Goh
Stereotactic body radiotherapy (SBRT) is increasingly used in the management of unresectable liver metastases and hepatocellular carcinoma (HCC) as it allows delivery of high-dose conformal radiotherapy with limited toxicities. However, it may be difficult to differentiate viable tumour from radiotherapy-related changes after SBRT. The imaging changes observed after SBRT may also differ from those observed following conventionally fractionated radiotherapy. Hence, we aim to review the imaging changes that occur within the tumour and adjacent normal liver after SBRT which may help to identify local relapse in clinical practice...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28893525/-doses-to-organs-at-risk-in-conformational-and-stereotactic-body-radiation-therapy-liver
#13
REVIEW
K Debbi, G Janoray, N Scher, É Deutsch, F Mornex
The liver is an essential organ that ensures many vital functions such as metabolism of bilirubin, glucose, lipids, synthesis of coagulation factors, destruction of many toxins, etc. The hepatic parenchyma can be irradiated during the management of digestive tumors, right basithoracic, esophagus, abdomen in toto or TBI. In addition, radiotherapy of the hepatic area, which is mainly stereotactic, now occupies a central place in the management of primary or secondary hepatic tumors. Irradiation of the whole liver, or part of it, may be complicated by radiation-induced hepatitis...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28888744/-stereotactic-body-radiotherapy-for-liver-tumors-state-of-the-art
#14
REVIEW
O Riou, D Azria, F Mornex
Thanks to the improvement in radiotherapy physics, biology, computing and imaging, patients presenting with liver tumors can be efficiently treated by radiation. Radiotherapy has been included in liver tumors treatment guidelines at all disease stages. Liver stereotactic radiotherapy has to be preferred to standard fractionated radiotherapy whenever possible, as potentially more efficient because of higher biological equivalent dose. Liver stereotactic radiotherapy planning and delivery require extensive experience and optimal treatment quality at every step, thus limiting its availability to specialized centres...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28875297/breathing-motion-compensated-robotic-guided-stereotactic-body-radiation-therapy-patterns-of-failure-analysis
#15
Susanne Stera, Panagiotis Balermpas, Mark K H Chan, Stefan Huttenlocher, Stefan Wurster, Christian Keller, Detlef Imhoff, Dirk Rades, Jürgen Dunst, Claus Rödel, Guido Hildebrandt, Oliver Blanck
PURPOSE: We retrospectively evaluated the patterns of failure for robotic guided real-time breathing-motion-compensated (BMC) stereotactic body radiation therapy (SBRT) in the treatment of tumors in moving organs. PATIENTS AND METHODS: Between 2011 and 2016, a total of 198 patients with 280 lung, liver, and abdominal tumors were treated with BMC-SBRT. The median gross tumor volume (GTV) was 12.3 cc (0.1-372.0 cc). Medians of mean GTV BEDα/β =10  Gy (BED = biological effective dose) was 148...
September 5, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28871989/long-term-outcomes-of-phase-1-and-2-studies-of-sbrt-for-hepatic-colorectal-metastases
#16
Andrew McPartlin, Anand Swaminath, Ri Wang, Melania Pintilie, James Brierley, John Kim, Jolie Ringash, Rebecca Wong, Rob Dinniwell, Tim Craig, Laura A Dawson
PURPOSE: To report mature outcomes of prospective phase 1 and 2 studies of stereotactic body radiation therapy (SBRT) for the treatment of colorectal liver metastases (CLMs). METHODS AND MATERIALS: Patients with histologically confirmed CLMs unsuitable for resection or standard therapies were eligible for sequential phase 1 and 2 studies conducted from 2003 to 2012. RESULTS: Of 60 patients treated, 82% had received previous chemotherapy, 23% had undergone previous focal liver treatment, and 38% had extrahepatic disease at the time of SBRT...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28864693/ablation-with-irreversible-electroporation-in-patients-with-advanced-perihilar-cholangiocarcinoma-alpaca-a-multicentre-phase-i-ii-feasibility-study-protocol
#17
Robert J S Coelen, Jantien A Vogel, Laurien G P H Vroomen, Eva Roos, Olivier R C Busch, Otto M van Delden, Foke van Delft, Michal Heger, Jeanin E van Hooft, Geert Kazemier, Heinz-Josef Klümpen, Krijn P van Lienden, Erik A J Rauws, Hester J Scheffer, Henk M Verheul, Jan de Vries, Johanna W Wilmink, Barbara M Zonderhuis, Marc G Besselink, Thomas M van Gulik, Martijn R Meijerink
INTRODUCTION: The majority of patients with perihilar cholangiocarcinoma (PHC) has locally advanced disease or distant lymph node metastases on presentation or exploratory laparotomy, which makes them not eligible for resection. As the prognosis of patients with locally advanced PHC or lymph node metastases in the palliative setting is significantly better compared with patients with organ metastases, ablative therapies may be beneficial. Unfortunately, current ablative options are limited...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28844122/clinical-significance-of-radiation-induced-liver-disease-after-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#18
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD. Methods: We retrospectively reviewed the medical records of 117 HCC patients who were treated by SBRT from March 2011 to February 2015. RILD was defined as elevated liver transaminases more than five times the upper normal limit or a worsening of Child-Pugh (CP) score by 2 within 3 months after SBRT...
August 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28839988/prognostic-significance-of-sites-of-extrathoracic-metastasis-in-patients-with-non-small-cell-lung-cancer
#19
James E Bates, Michael T Milano
BACKGROUND: Metastatic non-small cell lung cancer (NSCLC) continues to have a poor prognosis despite recent advances in both targeted radiotherapy methodologies such as stereotactic body radiotherapy (SBRT) and immunotherapies. The impact of location of metastatic disease in patients with NSCLC has not been investigated; we aimed to investigate this using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: We included 39,910 patients from the SEER database treated for M1b NSCLC from 2010-2013...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28839518/extrahepatic-metastasis-of-hepatocellular-carcinoma-to-the-paravertebral-muscle-a-case-report
#20
Kazuhiro Takahashi, Krishna G Putchakayala, Mohamed Safwan, Dean Y Kim
Identification of extrahepatic metastases (EHM) of hepatocellular carcinoma (HCC) has been paradoxically increasing due to an increase in the survival of HCC patients. However, metastasis of HCC to the skeletal muscle tissue is extremely rare. We describe a unique case of HCC metastasizing to the paravertebral muscle. A 55-year-old man with a history of hepatitis B cirrhosis underwent partial liver resection with complete removal of HCC. Three months later, a computed tomography (CT) scan showed intrahepatic recurrence...
August 8, 2017: World Journal of Hepatology
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