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Liver stereotactic

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https://www.readbyqxmd.com/read/28071340/respiration-induced-intraorgan-deformation-of-the-liver
#1
Anna K Paulsson, Sue S Yom, Mekhail Anwar, Dilini Pinnaduwage, Atchar Sudhyadhom, Alexander R Gottschalk, Albert J Chang, Martina Descovich
Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation by measuring the rigidity of the fiducial configuration during the breathing cycle. Seventeen patients, with 18 distinct treatment courses, were treated with stereotactic body radiosurgery using multiple fiducials. Liver deformation was empirically quantified by measuring the intrafiducial distances at different phases of respiration...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28058710/stereotactic-ablative-radiotherapy-for-patients-with-unresectable-or-medically-inoperable-cholangiocarcinoma
#2
Ming-Yueh Liu, Cheng-Hsiang Lo, Chun-Shu Lin, Hsing-Lung Chao, Jen-Fu Yang, Kuen-Tze Lin, Chao-Yueh Fan, Yu-Fu Su, Wen-Yen Huang
PURPOSE: The role of stereotactic ablative radiotherapy (SABR) in patients with unresectable or medically inoperable cholangiocarcinoma remains unclear. We examined the efficacy and safety of SABR in this group of patients. METHODS: From January 2008 to December 2014, 15 patients with 17 lesions were included in this study. The lesions included 14 intrahepatic, 1 hilar, and 2 distal bile duct tumors. Three patients were classified as medically inoperable because of old age or multiple comorbidities...
January 5, 2017: Tumori
https://www.readbyqxmd.com/read/28054139/-local-ablative-radiotherapy-of-oligometastatic-colorectal-cancer
#3
C Petersen, T Gauer
BACKGROUND: Colorectal cancer (CRC) often presents as oligometastatic disease. Currently available intensive systemic treatment regimens, including combination chemotherapy and molecular targeted agents, result in tumor response and transient to long-term disease control in a high percentage of patients, thus raising the question of further management. Secondary resection and ablation, e.g. by surgery or radiofrequency may contribute to long-term survival and even be curative or at least allow a relevant chemotherapy-free interval...
January 4, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28050151/eastern-canadian-gastrointestinal-cancer-consensus-conference-2016
#4
D Bossé, T Ng, C Ahmad, A Alfakeeh, I Alruzug, J Biagi, J Brierley, P Chaudhury, S Cleary, B Colwell, C Cripps, L A Dawson, M Dorreen, E Ferland, P Galiatsatos, S Girard, S Gray, F Halwani, N Kopek, A Mahmud, G Martel, L Robillard, B Samson, M Seal, J Siddiqui, L Sideris, S Snow, M Thirwell, M Vickers, R Goodwin, R Goel, T Hsu, E Tsvetkova, B Ward, T Asmis
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016 was held in Montreal, Quebec, 5-7 February. Experts in radiation oncology, medical oncology, surgical oncology, and infectious diseases involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics: ■ Follow-up and survivorship of patients with resected colorectal cancer■ Indications for liver metastasectomy■ Treatment of oligometastases by stereotactic body radiation therapy■ Treatment of borderline resectable and unresectable pancreatic cancer■ Transarterial chemoembolization in hepatocellular carcinoma■ Infectious complications of antineoplastic agents...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28048369/su-f-t-558-arccheck-for-patient-specific-qa-in-stereotactic-ablativeradiotherapy
#5
P Ramachandran, A Tajaldeen, D Taylor, D Wanigaratne, K Roozen, N Esen, M Geso, T Kron
PURPOSE: Stereotactic Ablative Radiotherapy (SABR) is one of the most preferred treatment techniques for early stage lung cancer. This technique has been extended to other treatment sites like Spine, Liver, Scapula, Sternum etc., This has resulted in increased physics QA time on machine. In this study, we've tested the feasibility of using ArcCheck as an alternative method to replace film dosimetry. METHODS: Twelve patients with varied diagnosis of Lung, Liver, scapula, sternum and Spine undergoing SABR were selected for this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048359/su-f-j-121-dosimetric-evaluation-of-active-breathing-coordinator-response-gating-system-linked-to-linear-accelerator-in-volumetric-modulated-arc-therapy
#6
S Lee, Y Zheng, D Albani, V Colussi, J Dorth, J Sohn
PURPOSE: To reduce internal target volume (ITV), respiratory management is a must in imaging and treatment for lung, liver, and breast cancers. We investigated the dosimetric accuracy of VMAT treatment delivery with a Response™ gating system linked to linear accelerator. METHODS: The Response™ gating module designed to directly control radiation beam by breath-holding with a ABC system (Elekta AB, Stockholm, Sweden) was tested for VMAT treatments. Seven VMAT plans including three conventional and four stereotactic body radiotherapy (SBRT) cases were evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048292/su-g-jep4-06-evaluation-of-interfractional-and-intrafractional-tumor-motion-in-stereotactic-liver-radiotherapy-based-on-four-dimensional-cone-beam-computed-tomography-using-fiducial-markers
#7
Y Shimohigashi, F Araki, R Toya, M Maruyama, Y Nakaguchi
PURPOSE: The purpose of this study was to evaluate the interfractional and intrafractional motion of liver tumors in stereotactic body radiation therapy (SBRT), based on four-dimensional cone-beam computed tomography using fiducial markers. (4D-CBCT). METHODS: Seven patients with liver tumors were treated by SBRT with abdominal compression (AC) in five fractions with image guidance based on 4D-CBCT. The 4D-CBCT studies were performed to determine the individualized internal margin for the planning simulation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048202/we-h-brc-02-failure-mode-and-effect-analysis-of-liver-stereotactic-body-radiotherapy
#8
I Rusu, T Thomas, J Roeske, J Price, C Perino, I Mescioglu, M Surucu
PURPOSE: To identify areas of improvement in our liver stereotactic body radiation therapy (SBRT) program, using failure mode and effect analysis (FMEA). METHODS: A multidisciplinary group consisting of one physician, three physicists, one dosimetrist and two therapists was formed. A process map covering 10 major stages of the liver SBRT program from the initial diagnosis to post treatment follow-up was generated. A total of 102 failure modes, together with their causes and effects, were identified...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048155/th-ef-brb-04-4%C3%AF-dynamic-conformal-arc-therapy-dynamic-conformal-arc-therapy-dcat-for-sbrt
#9
T Chiu, T Long, A Modiri, Z Tian, A Sawant, Y Yan, S Jiang, X Gu
PURPOSE: To develop an efficient and effective trajectory optimization methodology for 4π dynamic conformal arc treatment (4π DCAT) with synchronized gantry and couch motion; and to investigate potential clinical benefits for stereotactic body radiation therapy (SBRT) to breast, lung, liver and spine tumors. METHODS: The entire optimization framework for 4π DCAT inverse planning consists of two parts: 1) integer programming algorithm and 2) particle swarm optimization (PSO) algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048142/su-f-j-89-assessment-of-delivered-dose-in-understanding-hcc-tumor-progression-following-sbrt
#10
M McCulloch, G Cazoulat, D Polan, M Schipper, T Lawrence, M Feng, K Brock
PURPOSE: It is well documented that the delivered dose to patients undergoing radiotherapy (RT) is often different from the planned dose due to geometric variability and uncertainties in patient positioning. Recent work suggests that accumulated dose to the GTV is a better predictor of progression compared to the minimum planned dose to the PTV. The purpose of this study is to evaluate if deviations from the planned dose can contributed to tumor progression. METHODS: From 2010 to 2014 an in-house Phase II clinical trial of adaptive stereotactic body RT was completed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047828/su-f-t-563-delivered-dose-reconstruction-of-moving-targets-for-gated-volumetric-modulated-arc-therapy-vmat
#11
H Chung, C Jeong, S Cho, B Cho
PURPOSE: Actual delivered dose of moving tumors treated with gated volumetric arc therapy (VMAT) may significantly differ from the planned dose assuming static target. In this study, we developed a method which reconstructs actual delivered dose distribution of moving target by taking into account both tumor motion and dynamic beam delivery of gated VMAT, and applied to abdominal tumors. METHODS: Fifteen dual-arc VMAT plans (Eclipse, Varian Medical Systems) for 5 lung, 5 pancreatic, and 5 liver cancer patients treated with gated VMAT stereotactic body radiotherapy (SBRT) were studied...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047754/su-f-t-644-reproducibility-of-target-position-using-moderate-voluntary-breath-hold-during-liver-stereotactic-ablative-radiotherapy
#12
G Cui, N Trakul, E Chang, A Shiu
PURPOSE: To evaluate the reproducibility of target position using moderate voluntary breath-hold during liver stereotactic ablative radiotherapy (SABR). METHODS: Two patients who underwent liver SABR on a Varian TrueBeam STx linac were used for this study. Fiducial markers were placed in and around the target in the liver as surrogates for the target position and motion. GTVs were contoured by assessing tumor extent on contrast enhanced CT. The PTV was created from the GTV by adding 2 mm margins to account for the residual motion during breath-holds...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047646/su-f-t-606-monte-carlo-evaluation-of-tissue-inhomogeneity-corrections-in-the-treatment-of-liver-cancer-patients-using-stereotactic-body-radiotherapy
#13
D Pokhrel, S Sood, R Badkul, C McClinton, H Jiang, H Saleh, C Lominska
PURPOSE: To evaluate the dosimetric performance of X-ray Voxel Monte Carlo(XVMC) algorithm in effort to clinically validate Monte Carlo-approach in heterogeneous liver phantom and liver SBRT plans. METHODS: An anthropomorphic RPC liver phantom incorporating a liver structure with two cylindrical targets and organs-at-risk (OARs) was used in phantom validation. Subsequently, five patients with metastatic liver cancer were treated using heterogeneity-corrected pencil-beam(PB-hete)algorithm were analyzed following RTOG-1112 criteria ...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047539/su-f-j-136-impact-of-audiovisual-biofeedback-on-interfraction-motion-over-a-course-of-liver-cancer-stereotactic-body-radiotherapy
#14
S Pollock, R Tse, D Martin, L McLean, M Pham, D Tait, R Estoesta, G Whittington, J Turley, C Kearney, G Cho, R Hill, S Pickard, P Aston, K Makhija, R O'Brien, P Keall
PURPOSE: In abdominal radiotherapy inconsistent interfraction respiratory motion can result in deviations during treatment from what was planned in terms of target position and motion. Audiovisual biofeedback (AVB) is an interactive respiratory guide that produces a guiding interface that the patient follows over a course of radiotherapy to facilitate regular respiratory motion. This study assessed the impact of AVB on interfraction motion consistency over a course of liver cancer SBRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047328/mo-fg-campus-jep3-05-evaluation-of-4d-ct-on-rails-target-localization-methods-for-free-breathing-liver-stereotactic-body-radiotherapy-sbrt
#15
J Fan, T Lin, L Jin, L Chen, I Veltchev, L Wang, A Eldib, O Chibani, B Wang, Q Xu, R Price, C Ma
PURPOSE: Liver SBRT patients unable to tolerate breath-hold for radiotherapy are treated free-breathing with image guidance. Target localization using 3D CBCT requires extra margins to accommodate the respiratory motion. The purpose of this study is to evaluate the accuracy and reproducibility of 4D CT-on-rails in target localization for free-breathing liver SBRT. METHODS: A Siemens SOMATOM CT-on-Rails 4D with Anzai Pressure Belt system was used both as the simulation and the localization CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047290/tu-h-brc-02-biological-dose-escalation-for-liver-sbrt-through-spatiotemporal-fractionation
#16
J Unkelbach, Z Perko, J Wolfgang, T Hong
PURPOSE: Stereotactic body radiotherapy (SBRT) has become an established treatment option for liver cancer. For patients with large tumors, the prescription dose is often limited by constraints on the mean liver dose, leading to tumor recurrence. In this work, we demonstrate that spatiotemporal fractionation schemes, ie delivering distinct dose distributions in different fractions, may allow for a 10% increase in biologically effective dose (BED) in the tumor compared to current practice where each fraction delivers the same dose distribution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047214/su-f-t-260-using-portal-image-device-for-pre-treatment-qa-in-volumetric-modulated-arc-plans-with-flattening-filter-free-fff-beams
#17
H Qu, P Qi, N Yu, P Xia
PURPOSE: To implement and validate a method of using electronic portal image device (EPID) for pre-treatment quality assurance (QA) of volumetric modulated arc therapy (VMAT) plans using flattering filter free (FFF) beams for stereotactic body radiotherapy (SBRT). METHODS: On Varian Edge with 6MV FFF beam, open field (from 2×2 cm to 20×20 cm) EPID images were acquired with 200 monitor unit (MU) at the image device to radiation source distance of 150cm. With 10×10 open field and calibration unit (CU) provided by vendor to EPID image pixel, a dose conversion factor was determined by dividing the center dose calculated from the treatment planning system (TPS) to the corresponding CU readout on the image...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046919/su-f-t-619-dose-evaluation-of-specific-patient-plans-based-on-monte-carlo-algorithm-for-a-cyberknife-stereotactic-radiosurgery-system
#18
J Piao, S Xu, Z Wu, Y Li, B Qu, X Duan, Y Liu
PURPOSE: This study will use Monte Carlo to simulate the Cyberknife system, and intend to develop the third-party tool to evaluate the dose verification of specific patient plans in TPS. METHODS: By simulating the treatment head using the BEAMnrc and DOSXYZnrc software, the comparison between the calculated and measured data will be done to determine the beam parameters. The dose distribution calculated in the Raytracing, Monte Carlo algorithms of TPS (Multiplan Ver4...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046812/su-g-brb-07-developing-a-qa-procedure-for-gated-vmat-sabr-treatments-using-10-mv-beam-in-flattening-filter-free-mode
#19
S Chitsazzadeh, D Wells, A Mestrovic
PURPOSE: To develop a QA procedure for gated VMAT stereotactic ablative radiotherapy (SABR) treatments. METHODS: An interface was constructed to attach the translational stage of a Quasar respiratory motion phantom to a pinpoint ion chamber insert and move the ion chamber inside an ArcCheck diode array. The Quasar phantom controller used a patient specific breathing pattern to translate the ion chamber in a superior-inferior direction inside the ArcCheck. An amplitude-based RPM tracking system was specified to turn the beam on during the exhale phase of the breathing pattern...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046273/su-f-t-586-pre-treatment-qa-of-incise2-mlc-plans-on-a-cyberknife-m6-using-the-delta4-system-in-sbrt
#20
D Schmidhalter, D Henzen, M Malthaner, D Frauchiger, M K Fix, P Manser
PURPOSE: Performing pre-treatment quality assurance (QA) with the Delta4 system (ScandiDos Inc., Madison, WI) is well established for linac-based radiotherapy. This is not true when using a Cyberknife (Accuray Inc., Sunnyvale, CA) where, typically film-based QA is applied. The goal of this work was to test the feasibility to use the Delta4 system for pre-treatment QA for stereotactic body radiation therapy (SBRT) using a Cyberknife-M6 equipped with the InCise2 multileaf collimator (MLC)...
June 2016: Medical Physics
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