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Liver stereotactic

David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth
PURPOSE: Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional dose-volume histograms. Thresholds predicting for decompensation during follow up are evaluated. METHODS AND MATERIALS: We studied 17 patients who underwent HIDA scans before SBRT...
May 1, 2018: Practical Radiation Oncology
Heather M McGee, Megan E Daly, Sohelia Azghadi, Susan L Stewart, Leslie Oesterich, Jeffrey Schlom, Renee Donahue, Jonathan D Schoenfeld, Qian Chen, Shyam Rao, Ruben C Fragoso, Richard K Valicenti, Robert J Canter, Emmanual M Maverakis, William J Murphy, Karen Kelly, Arta M Monjazeb
PURPOSE: Despite the strong interest in combining stereotactic ablative radiation therapy (SAR) with immunotherapy, limited data characterizing the systemic immune response after SAR are available. We hypothesized that the systemic immune response to SAR would differ by irradiated site owing to inherent differences in the microenvironment of various organs. METHODS AND MATERIALS: Patients receiving SAR to any organ underwent prospective blood banking before and 1 to 2 weeks after SAR...
April 22, 2018: International Journal of Radiation Oncology, Biology, Physics
D Putzer, P Schullian, E Braunwarth, M Fodor, F Primavesi, B Cardini, T Resch, R Oberhuber, M Maglione, C Margreiter, S Schneeberger, S Stättner, D Öfner-Velano, W Jaschke, R J Bale
Background: Percutaneous ablation techniques offer a vast armamentarium for local, minimally invasive treatment of liver tumors, nowadays representing an established therapeutic option, which is integrated in treatment algorithms, especially for non-resectable liver tumors. The results of ablative treatment compare very well to surgical treatment in liver lesions, and confirm that these techniques are a valuable option for bridging for transplantation. Different techniques have been established to perform tumor ablation, and the feasibility varies according to the procedure and technical skills of the operator, depending on the size and location of the liver lesion...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
Tom Williamson, Wa Cheung, Stuart K Roberts, Sunita Chauhan
PURPOSE: With the ongoing shift toward reduced invasiveness in many surgical procedures, methods for tracking moving targets within the body become vital. Non-invasive treatment methods such as stereotactic radiation therapy and high intensity focused ultrasound, in particular, rely on the accurate localization of targets throughout treatment to ensure optimal treatment provision. This work aims at developing a robust, accurate and fast method for target tracking based on ultrasound images...
June 5, 2018: International Journal of Computer Assisted Radiology and Surgery
Thomas Ravkilde, Simon Skouboe, Rune Hansen, Esben Worm, Per R Poulsen
PURPOSE: In radiotherapy, dose deficits caused by tumor motion often far outweigh the discrepancies typically allowed in plan-specific quality assurance (QA). Yet, tumor motion is not usually included in present QA. We here present a novel method for online treatment verification by real-time motion-including 4D dose reconstruction and dose evaluation and demonstrate its use during stereotactic body radiotherapy (SBRT) delivery with and without MLC tracking. METHODS: Five volumetric modulated arc therapy (VMAT) plans were delivered with and without MLC tracking to a motion stage carrying a Delta4 dosimeter...
June 5, 2018: Medical Physics
Yeyu Cai, Qian Chang, Enhua Xiao, Quan-Liang Shang, Zhu Chen
To compare the clinical efficacies and adverse reactions between transcatheter arterial chemoembolization (TACE), γ-ray 3-dimensional fractionated stereotactic conformal radiotherapy (FSCR), and TACE combined with FSCR for primary hepatocellular carcinoma.The study was approved by the Institutional Review Board, and informed consent was waived due to the retrospective study design. About 121 patients met the inclusion criteria and were included in this study, from March 2008 to January 2010, in the Second Xiangya Hospital...
June 2018: Medicine (Baltimore)
Chai Hong Rim, Won Sup Yoon
The use of external beam radiation therapy (EBRT) in the treatment of hepatocellular carcinoma (HCC), which was rarely performed due to liver toxicity with a previous technique, has increased. Palliation of portal vein thrombosis, supplementation for insufficient transarterial chemoembolization, and provision of new curative opportunities using stereotactic body radiotherapy are the potential indications for use of EBRT. The mechanism of EBRT treatment, with its radiobiological and physical perspectives, differs from those of conventional medical treatment or surgery...
2018: OncoTargets and Therapy
Sabine Gerum, Christian Heinz, Claus Belka, Franziska Walter, Philipp Paprottka, Enrico N De Toni, Falk Roeder
BACKGROUND: To report our experience with SBRT in primary and secondary liver tumors. METHODS: We retrospectively analysed 55 patients (70 lesions) with a median follow-up of 10 months (range 1-57) treated from 2011 to 2016. All patients had not been eligible for other local treatment options. Median age was 64 years and 64% were male. 27 patients (36 lesions) suffered from hepatocellular carcinoma (HCC, Child A:78%, Child B:18%, Child C:4%), 28 patients (34 lesions) had oligometastatic liver disease (MD)...
May 29, 2018: Radiation Oncology
Ricardo Alencar Vilela, Natássia Ferreira Navarro, Edison Tostes Faria, Elaine Barros Ferreira, Rachel Zomer Ruzza, Rafael Gadia, Eliete Neves Silva Guerra, Paula Elaine Diniz Dos Reis
The purpose of this study is to evaluate the effectiveness and safety of stereotactic body radiation therapy (SBRT) in the management of oligometastatic recurrent prostate cancer (PCa) by means of a systematic review. Six databases were searched (CENTRAL, Embase, LILACS, PubMed, Scopus and Web of Science). Additionally, hand-searching and grey literature search were performed. The main outcomes were progression-free survival (PFS) and toxicity rates. Androgen deprivation therapy-free survival (ADT-FS), local control, pattern of recurrence, cancer-specific survival and overall survival were also assessed...
May 28, 2018: Journal of Medical Imaging and Radiation Oncology
Wei-Jun Wang, Jeng-Fong Chiou, Yaoru Huang
The prognosis of patients with metastatic cancers has improved in the past decades due to effective chemotherapy and oligometastatic surgery. For inoperable patients, local ablation therapies, such as stereotactic body radiotherapy (SBRT), can provide effective local tumor control with minimal toxicity. Because of its high precision and accuracy, SBRT delivers a higher radiation dose per fraction, is more effective, and targets smaller irradiation volumes than does conventional radiotherapy. In addition, steep dose gradients from target lesions to surrounding normal tissues are achieved using SBRT; thus, SBRT provides more effective tumor control and exhibits fewer side effects than conventional radiotherapy...
May 8, 2018: Journal of Visualized Experiments: JoVE
Rosario Mazzola, Sergio Fersino, Pierpaolo Alongi, Gioacchino Di Paola, Fabiana Gregucci, Dario Aiello, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVE: To investigate metabolic parameters as predictive of local response after stereotactic body radiation therapy (SBRT) for liver-oligometastases. METHODS: Inclusion criteria of the present retrospective study were: (a) liver oligometastases with controlled primary tumor; (b) absence of progressive disease ≥6 months; (c) metastases ≤ 3; (d) evaluation of SBRT-response by means of 18-fludeoxyglucose-PET/CT for at least two subsequent evaluations; (e) Karnofsky performance status >80; (f) life-expectancy >6 months...
May 23, 2018: British Journal of Radiology
Luca Boldrini, Francesco Cellini, Stefania Manfrida, Giuditta Chiloiro, Stefania Teodoli, Davide Cusumano, Bruno Fionda, Gian Carlo Mattiucci, Anna Maria De Gaetano, Luigi Azario, Vincenzo Valentini
The case of a 73-year-old woman affected by anal canal cancer with concomitant liver metastases is presented here. The patient was addressed to stereotactic body radiotherapy (SBRT) on two hepatic secondary lesions after the first radiochemotherapy treatment of the primary tumor. A Tri-60-Co magnetic resonance hybrid radiotherapy unit was used for SBRT treatment delivery. Both liver lesions were not clearly visible on the setup magnetic resonance imaging (MRI) due to their limited dimensions (maximum diameter 13 mm); however, the presence of two cysts adjacent to the metastases allowed the use of an indirect target gating approach...
March 9, 2018: Curēus
Edouard Massaut, Ali Bohlok, Valerio Lucidi, Alain Hendlisz, Jean Klastersky, Vincent Donckier
PURPOSE OF REVIEW: The concept of oligometastases, defining cancers with limited metastatic capacity and attaining a limited number of secondary sites, is now widely accepted, particularly in colorectal cancer. Currently, however, accurate predictive markers for oligometastatic tumors are still lacking. For this reason, it remains challenging to translate this concept into clinical recommendations. In the present work, we review recent publications on oligometastases in colorectal cancer, showing the evidences for such presentation and underlying the need for the identification of biomarkers, necessary to further develop new therapeutic strategies...
May 4, 2018: Current Opinion in Oncology
L P Beyer, L Lürken, N Verloh, M Haimerl, K Michalik, J Schaible, C Stroszczynski, P Wiggermann
PURPOSE: To compare CT-navigated stereotactic microwave ablation (SMWA) to non-navigated conventional MWA (CMWA) for percutaneous ablation of liver malignancies. METHODS: A matched pair analysis of 36 patients who underwent MWA of primary or secondary liver malignancies (10 hepatocellular carcinoma and 8 metastases) was conducted. A total of 18 patients undergoing SMWA were included in this prospective study. Patients were matched in terms of tumor size, liver segment and entity to retrospective CMWA procedures...
May 4, 2018: International Journal of Computer Assisted Radiology and Surgery
Eun Kyung Paik, Mi-Sook Kim, Young-Seok Seo, Won Jang, Jin-Kyu Kang, Chul-Koo Cho, Hyung Jun Yoo
Background: There is growing interest in the use of stereotactic ablative radiotherapy (SABR) for oligometastases. However, extreme caution should be exercised in treating tumors closely located to organs at risk (OARs) with SABR. To reduce complications, we have applied split-course SABR to oligometastases closely located to OARs or to those being retreated with radiotherapy. Methods: We retrospectively reviewed the records of patients with oligometastases who were treated with planned split-course SABR between January 2012 and December 2016...
May 2, 2018: Japanese Journal of Clinical Oncology
Stephen James Ramey, Kyle R Padgett, Narottam Lamichhane, Hanmath J Neboori, Deukwoo Kwon, Eric A Mellon, Karen Brown, Melissa Duffy, James Victoria, Nesrin Dogan, Lorraine Portelance
PURPOSE: This study aims to perform a dosimetric comparison of 2 magnetic resonance (MR)-guided radiation therapy systems capable of performing online adaptive radiation therapy versus a conventional radiation therapy system for pancreas stereotactic body radiation therapy. METHODS AND MATERIALS: Ten cases of patients with pancreatic adenocarcinoma previously treated in our institution were used for this analysis. MR-guided tri-cobalt 60 therapy (MR-cobalt) and MR-LINAC plans were generated and compared with conventional LINAC (volumetric modulated arc therapy) plans...
March 1, 2018: Practical Radiation Oncology
Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi, Hideki Nishimura
BACKGROUND: Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or liver metastases. The purpose of this study was to investigate the efficacy and safety of SBRT for lung and liver oligo-recurrent lesions and evaluate predictive factors for local control and prognosis. METHODS: This retrospective study included patients who presented with 1-3 matachronous lung or liver metastases, and treated with SBRT between May 2013 and March 2016 at a single institution...
April 23, 2018: Radiation Oncology
Sebastian Stintzing, Jobst von Einem, Christoph Fueweger, Alfred Haidenberger, Michael Fedorov, Alexander Muavcevic
Purpose: The treatment of liver metastases with local procedures is a fast progressing field. For the most, long-term survival data is missing raising questions with regard to the efficacy of such modalities when compared to surgical resection. Radiosurgery using the CyberKnife device enables the treatment of liver lesions with a single-session approach. Here we present long-term survival data to explore the curative potential of this strategy. Materials and Methods: Patients with oligo-metastatic disease limited to the liver have been treated with single-session or hypo-fractioned radiosurgery in curative intent and prospectively followed until death...
April 16, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Gerda Földi, Csaba Polgár, Zsuzsánna Zongor, Barbara Melles-Bencsik, Gábor Stelczer, Balázs Madaras, Tamás Pintér, Éva Jederán, József Lövey
Recently the prevalence of oligometastatic patients is increasing. A common site of distant spread is the liver. The standard of care is curative surgical resection, however, the resecability rate is only 10-20%. Alternatively, radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) may be used. Stereotactic ablative body radiotherapy (SABRT) makes it possible to deliver curative radiation dose without radiation injury to the healthy liver tissue. We delivered SABRT to three patients with inoperable hepatic metastases...
March 23, 2018: Magyar Onkologia
András Bibok, Attila Doros
Invasive radiological procedures provide more and more therapeutic options for patients with liver cancer. The treatment options previously used as a 2nd/3rd line treatment are making their way to 1st line treatment in selected cases. In this review, the authors take an overview of the interventional radiological procedures used in the most frequent liver neoplasms. There is a rapid development in ablational therapy, especially in the volumetric planning and stereotactic navigation. Using those new devices, the reliability of the ablation can improve a lot...
March 23, 2018: Magyar Onkologia
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