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https://www.readbyqxmd.com/read/29450985/effect-of-secondary-electron-generation-on-dose-enhancement-in-lipiodol-with-and-without-a-flattening-filter
#1
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
PURPOSE: Lipiodol, which was used in transcatheter arterial chemoembolization before liver stereotactic body radiation therapy (SBRT), remains in SBRT. Previous we reported the dose enhancement in Lipiodol using 10 MV (10×) FFF beam. In this study, we compared the dose enhancement in Lipiodol and evaluated the probability of electron generation (PEG) for the dose enhancement using flattening filter (FF) and flattening filter free (FFF) beams. METHODS: FF and FFF for 6 MV (6×) and 10× beams were delivered by TrueBeam...
February 15, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29439707/stereotactic-body-radiotherapy-sbrt-for-liver-metastasis-clinical-outcomes-from-the-international-multi-institutional-rssearch%C3%A2-patient-registry
#2
Anand Mahadevan, Oliver Blanck, Rachelle Lanciano, Anuj Peddada, Srinath Sundararaman, David D'Ambrosio, Sanjeev Sharma, David Perry, James Kolker, Joanne Davis
BACKGROUND: Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver metastases in patients unsuitable for surgery. We investigated factors associated with clinical outcomes for liver metastases treated with SBRT from a multi-center, international patient registry. METHODS: Patients with liver metastases treated with SBRT were identified in the RSSearch® Patient Registry. Patient, tumor and treatment characteristics associated with treatment outcomes were assessed...
February 13, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29432550/strategies-for-prediction-and-mitigation-of-radiation-induced-liver-toxicity
#3
Diego A S Toesca, Bulat Ibragimov, Amanda J Koong, Lei Xing, Albert C Koong, Daniel T Chang
Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a 'classic' form, composed of anicteric hepatomegaly, ascites and elevated alkaline phosphatase; and a 'non-classic' form, with liver transaminases elevated to more than five times the reference value, or worsening of liver metabolic function represented as an increase of 2 or more points in the Child-Pugh score classification...
February 8, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29427352/a-rare-case-of-epstein-barr-virus-associated-hepatosplenic-smooth-muscle-tumors-after-kidney-transplantation
#4
Christoph Pircher, Stefan Schneeberger, Claudia Boesmueller, Abbas Agaimy, Heinz Zoller, Reto Bale, Benjamin Henninger, Gert Mayer, Hannes Neuwirt
A 27-year old caucasian male was diagnosed 2.7 years after kidney transplantation with Epstein-Barr virus (EBV)-associated smooth muscle tumors in liver and spleen. The reduction of immunosuppression and conversion from tacrolimus to sirolimus did not lead to a regression of the tumors. Additionally, the patient developed a cellular rejection of his renal allograft, which was successfully treated. A combined approach with stereotactic radiofrequency ablation (SRFA) and surgical resection was effective in the treatment of the tumors...
February 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29426691/toward-consensus-reporting-of-radiation-induced-liver-toxicity-in-the-treatment-of-primary-liver-malignancies-defining-clinically-relevant-endpoints
#5
Tobias R Chapman, Stephen R Bowen, Stephanie K Schaub, Rosanna H Yeung, Sharon W Kwan, James O Park, Lei Yu, William P Harris, Guy E Johnson, Iris W Liou, Matthew J Nyflot, Smith Apisarnthanarax
BACKGROUND: Our purpose was to define the most clinically relevant "nonclassic" radiation-induced liver disease (RILD) endpoints in cirrhotic patients receiving stereotactic body radiation therapy or proton beam therapy for primary liver cancer. METHODS AND MATERIALS: We retrospectively collected pretreatment, detailed toxicity (≤6 months posttreatment), and outcomes data from 48 patients. Deaths were examined for association with RILD. Univariate and multivariate Cox models defined significant predictors of overall survival (OS)/RILD-specific survival (RILD-SS)...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29423821/the-emerging-role-of-stereotactic-radiotherapy-in-gastrointestinal-malignancies-a-review-of-the-literature-and-analysis-from-the-irish-perspective
#6
Siobhra O'Sullivan, Daniel N Cagney
Primary and secondary malignancies of the liver and pancreas result in significant morbidity and mortality, with increasing incidence and increasing demands on health services worldwide. Surgery is the only curative single modality of treatment and remains the gold standard. Unfortunately, up to 80% of the patients present with unresectable disease, and so, alternative efficacious local and systemic treatments are needed. Technologic advances in radiotherapy over recent decades have meant that precision high-dose treatment with stereotactic body radiotherapy (SBRT) has emerged as a viable cost-effective outpatient-based treatment in the management of these difficult to treat abdominal malignancies...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29423737/aggressive-and-multidisciplinary-local-approach-to-iterative-recurrences-of-colorectal-liver-metastases
#7
Luca Viganò, Vittorio Pedicini, Tiziana Comito, Carlo Carnaghi, Guido Costa, Dario Poretti, Ciro Franzese, Nicola Personeni, Daniele Del Fabbro, Lorenza Rimassa, Marta Scorsetti, Armando Santoro, Luigi Solbiati, Guido Torzilli
BACKGROUND: Liver resection (LR) of colorectal metastases is associated with high recurrence risk. Aggressive local retreatment is advocated, but further recurrences may occur. Poor is known about presentation, treatment, and outcome of iterative recurrences. METHODS: A series of 323 consecutive patients undergoing first LR in the period 2004-2013 was reviewed. Patients with recurrence were included. Any local treatment (surgery, radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT)) was analyzed...
February 8, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29413273/safety-and-efficacy-of-accelerated-hypofractionation-and-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-patients-with-varying-degrees-of-hepatic-impairment
#8
Nima Nabavizadeh, Joseph G Waller, Robert Fain, Yiyi Chen, Catherine R Degnin, David A Elliott, Brandon T Mullins, Ishan A Patel, Brandon A Dyer, Kareem Fakhoury, Willscott E Naugler, Khashayar Farsad, James A Tanyi, Martin Fuss, Charles R Thomas, Arthur Y Hung
PURPOSE: To report the toxicities and outcomes for stereotactic body radiation therapy (SBRT) and accelerated hypofractionated radiation therapy (AHRT) in patients with Child-Pugh (CP) class A, B, or C and albumin-bilirubin (ALBI) score 1, 2, or 3 hepatocellular carcinoma. METHODS AND MATERIALS: We retrospectively reviewed the data from 146 patients with hepatocellular carcinoma who had undergone SBRT (50 Gy in 5 fractions) or AHRT (45 Gy in 18 fractions). The primary endpoint was liver toxicity, defined as an increase in the CP score of ≥2 within 6 months of radiation therapy...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29405637/impact-of-audiovisual-biofeedback-on-interfraction-respiratory-motion-reproducibility-in-liver-cancer-stereotactic-body-radiotherapy
#9
Sean Pollock, Regina Tse, Darren Martin, Lisa McLean, Melissa Pham, David Tait, Reuben Estoesta, Grant Whittington, Jessica Turley, Christopher Kearney, Gwi Cho, Robin Hill, Sheila Pickard, Paul Aston, Kuldeep Makhija, Ricky O'Brien, Paul Keall
INTRODUCTION: Irregular breathing motion exacerbates uncertainties throughout a course of radiation therapy. Breathing guidance has demonstrated to improve breathing motion consistency. This was the first clinical implementation of audiovisual biofeedback (AVB) breathing guidance over a course of liver stereotactic body radiotherapy (SBRT) investigating interfraction reproducibility. METHODS: Five liver cancer patients underwent a screening procedure prior to CT sim during which patients underwent breathing conditions (i) AVB, or (ii) free breathing (FB)...
February 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29404626/direct-dose-correlation-of-mri-morphologic-alterations-of-healthy-liver-tissue-after-robotic-liver-sbrt
#10
Judit Boda-Heggemann, Anika Jahnke, Mark K H Chan, Leila S Ghaderi Ardekani, Peter Hunold, Jost Philipp Schäfer, Stefan Huttenlocher, Stefan Wurster, Dirk Rades, Guido Hildebrandt, Frank Lohr, Jürgen Dunst, Frederik Wenz, Oliver Blanck
PURPOSE: For assessing healthy liver reactions after robotic SBRT (stereotactic body radiotherapy), we investigated early morphologic alterations on MRI (magnetic resonance imaging) with respect to patient and treatment plan parameters. PATIENTS AND METHODS: MRI data at 6-17 weeks post-treatment from 22 patients with 42 liver metastases were analyzed retrospectively. Median prescription dose was 40 Gy delivered in 3-5 fractions. T2- and T1-weighted MRI were registered to the treatment plan...
February 5, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29395629/temporary-removal-local-control-after-stereotactic-body-radiation-therapy-for-liver-tumors
#11
Nitin Ohri, Wolfgang A Tomé, Alejandra Méndez Romero, Moyed Mifften, Randall K Ten Haken, Laura A Dawson, Jimm Grimm, Ellen Yorke, Andrew Jackson
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at www.elsevier.com/locate/withdrawalpolicy.
January 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29394842/-stereotactic-body-radiotherapy-for-liver-metastasis-of-gastric-cancer
#12
So Katayanagi, Yousuke Makuuchi, Hiroaki Osakabe, Masatoshi Shigoka, Tetsuo Sumi, Akihiko Tsuchida, Shigeyuki Kawachi
Case 1: A 69-year-old man underwent distal gastrectomy in September 2007 for type 2 gastric cancer with liver metastasis (S5). After the operation, we administered chemotherapy. After that, we performed partial hepatectomy in July 2008. After hepatectomy, liver metastases appeared as 2 lesions in February 2009. Thus, we administered another type of chemotherapy. The effect of the chemotherapy was not favorable. Therefore, SBRT was performed for the liver metastases in December. After SBRT, he did not present with any recurrent tumors...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29378624/evaluation-of-the-tumor-movement-and-the-reproducibility-of-two-different-immobilization-setups-for-image-guided-stereotactic-body-radiotherapy-of-liver-tumors
#13
Constantin Dreher, Markus Oechsner, Michael Mayinger, Stefanie Beierl, Marciana-Nona Duma, Stephanie E Combs, Daniel Habermehl
BACKGROUND: The purpose of this study is to evaluate the tumor movement and accuracy of patient immobilization in stereotactic body radiotherapy of liver tumors with low pressure foil or abdominal compression. METHODS: Fifty-four liver tumors treated with stereotactic body radiotherapy were included in this study. Forty patients were immobilized by a vacuum couch with low pressure foil, 14 patients by abdominal compression. We evaluated the ratio of gross tumor volume/internal target volume, the tumor movement in 4D-computed tomography scans and daily online adjustments after cone beam computed tomography scans...
January 30, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29374726/clinical-assessment-of-micro-residual-tumors-during-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#14
Kenji Uemoto, Hiroshi Doi, Hiroya Shiomi, Koichi Yamada, Daisaku Tatsumi, Taku Yasumoto, Masaaki Takashina, Masahiko Koizumi, Ryoong-Jin Oh
BACKGROUND: This study aimed to assess the need to consider microscopic invasion in terms of treatment planning in stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma and elucidate the appropriate clinical target volume (CTV) margin. PATIENTS AND METHODS: A total of 121 patients (with 146 liver tumors) who underwent SBRT between July 2007 and August 2016 were analyzed, regarding overall survival and local control (LC). RESULTS: The 2- and 5-year LC rates were 91...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29374681/stereotactic-body-radiation-therapy-for-liver-tumors-current-status-and-perspectives
#15
REVIEW
Hiroshi Doi, Naohito Beppu, Kazuhiro Kitajima, Kozo Kuribayashi
Surgical resection is the standard therapy for solitary primary or metastatic liver tumors. However, liver tumors are often unresectable at diagnosis and hepatectomy is invasive. Local therapies, such as radiofrequency ablation, are used instead, which can be challenging. Recent advances in modern radiotherapy, including stereotactic body radiation therapy (SBRT), have increased the use of radiotherapy as a curative modality. SBRT delivers ablative high doses of irradiation in small volumes. SBRT for liver tumors provided local control with potential survival benefits in patients with inoperable status...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29366521/a-prospective-study-of-the-safety-and-efficacy-of-liver-stereotactic-body-radiotherapy-in-patients-with-and-without-prior-liver-directed-therapy
#16
Dominic H Moon, Andrew Z Wang, Joel E Tepper
BACKGROUND AND PURPOSE: To evaluate the safety and efficacy of liver stereotactic body radiotherapy (SBRT), and examine potential factors impacting outcomes including prior liver-directed therapy. MATERIALS AND METHODS: Patients with ECOG 0-1, Child-Pugh Class A or B, and primary hepatocellular carcinoma (HCC) or liver metastases unsuitable for surgical resection or ablation were eligible for a prospective single arm trial. SBRT was delivered with a CyberKnife system to 45 Gy in 3 fractions with a predetermined dose de-escalation scheme...
January 20, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29359031/hepatocellular-carcinoma-with-child-pugh-a-cirrhosis-treated-with-stereotactic-body-radiotherapy
#17
Shaakir Hasan, Ngoc Thai, Tadahiro Uemura, Vijay Kudithipudi, Paul Renz, Stephen Abel, Alexander V Kirichenko
AIM: To evaluate the control, survival, and hepatic function for Child Pugh (CP)-A patients after Stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC). METHODS: From 2009 to 2016, 40 patients with Barcelona Liver Clinic (BCLC) stages 0-B HCC and CP-A cirrhosis completed liver SBRT. The mean prescription dose was 45 Gy (40 to 50 Gy in 4-5 fractions). Local relapse, defined as recurrence within the planning target volume was assessed with intravenous multiphase contrast computed tomography or magnetic resonance imaging every 4-6 mo after completion of SBRT...
December 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29353652/modeling-of-normal-tissue-complications-using-imaging-and-biomarkers-after-radiation-therapy-for-hepatocellular-carcinoma
#18
Issam El Naqa, Adam Johansson, Dawn Owen, Kyle Cuneo, Yue Cao, Martha Matuszak, Latifa Bazzi, Theodore S Lawrence, Randall K Ten Haken
PURPOSE: To develop normal tissue complications (NTCP) models for hepatocellular cancer (HCC) patients who undergo liver radiation therapy (RT) and to evaluate the potential role of functional imaging and measurement of blood-based circulating biological markers before and during RT to improve the performance of these models. METHODS AND MATERIALS: The data from 192 HCC patients who had undergone RT from 2005 to 2014 were evaluated. Of the 192 patients, 146 had received stereotactic body RT (SBRT) and 46 had received conventional RT to a median physical tumor dose of 49...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29351303/automated-inverse-optimization-facilitates-lower-doses-to-normal-tissue-in-pancreatic-stereotactic-body-radiotherapy
#19
Ivaylo B Mihaylov, Eric A Mellon, Raphael Yechieli, Lorraine Portelance
PURPOSE: Inverse planning is trial-and-error iterative process. This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: The automation is based on stepwise reduction of dose-volume histograms (DVHs). Five uniformly spaced points, from 1% to 70% of the organ at risk (OAR) volumes, are used...
2018: PloS One
https://www.readbyqxmd.com/read/29336348/optimizing-highly-noncoplanar-vmat-trajectories-the-novo-method
#20
Marco Langhans, Jan Unkelbach, Thomas Bortfeld, David Craft
We introduce a new method called NoVo (Noncoplanar VMAT Optimization) to produce volumetric modulated arc therapy (VMAT) treatment plans with noncoplanar trajectories. While the use of noncoplanar beam arrangements for intensity modulated radiation therapy (IMRT), and in particular high fraction stereotactic radiosurgery (SRS), is common, noncoplanar beam trajectories for VMAT are less common as the availability of treatment machines handling these is limited. For both IMRT and VMAT, the beam angle selection problem is highly nonconvex in nature, which is why automated beam angle selection procedures have not entered mainstream clinical usage...
January 16, 2018: Physics in Medicine and Biology
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