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venous Malformations anticoagulation

Haiyan Zhao, Jintao Han, Ming Lu, Yingshuang Zhang, Dongsheng Fan
OBJECTIVE: To explore the incidence and possible underlying pathogenic mechanisms of nontraumatic convexal subarachnoid haemorrhage (cSAH; a rarely reported condition) in a cohort of Chinese patients. METHODS: Medical records from all patients with subarachnoid haemorrhage (SAH) who had been treated at Peking University Third Hospital, China, between January 2010 and December 2014 were retrospectively reviewed to identify cases of cSAH. RESULTS: Of 144 patients with SAH, cSAH was observed in 14 cases (9...
July 7, 2016: Journal of International Medical Research
Elchanan Bruckheimer
The absolute separation of the right and left circulations and the filtration of blood by the pulmonary circulation are essential to prevent the passage of thrombotic material from the venous system into the systemic arterial circulation. Any breach of the intracardiac septae or circumvention of the pulmonary capillary network may cause a paradoxical embolus. The most common causes are atrial septal defects and pulmonary arteriovenous malformations. This article discusses unusual connections and pathways related to congenital malformations...
May 2016: Cardiology Clinics
Hormuzdiyar H Dasenbrock, Sandra C Yan, Bradley A Gross, Donovan Guttieres, William B Gormley, Kai U Frerichs, M Ali Aziz-Sultan, Rose Du
OBJECTIVE Although aspirin usage may be associated with a decreased risk of rupture of cerebral aneurysms, any potential therapeutic benefit from aspirin must be weighed against the theoretical risk of greater hemorrhage volume if subarachnoid hemorrhage (SAH) occurs. However, few studies have evaluated the association between prehemorrhage aspirin use and outcomes. This is the first nationwide analysis to evaluate the impact of long-term aspirin and anticoagulant use on outcomes after SAH. METHODS Data from the Nationwide Inpatient Sample (NIS; 2006-2011) were extracted...
February 2017: Journal of Neurosurgery
Wenjun Ji, Aihua Liu, Xianli Lv, Youxiang Li, Xinjian Yang, Chuhan Jiang, Zhongxue Wu
BACKGROUND: Endovascular coil embolization of pial arteriovenous fistulas (AVF) has been reported as an effective treatment. However, venous thrombosis and intracranial hemorrhage developing after endovascular occlusion of a pial AVF have not been adequately reported. CASE DESCRIPTION: A 37-year-old man presented with left middle cerebral artery (MCA) AVF and right posterior cerebral artery (PCA) AVF with giant venous pouches. Staged endovascular coil embolization was performed...
February 2016: Interventional Neuroradiology
Vishal J Patel, Rishi R Lall, Sohum Desai, Aaron Mohanty
Developmental venous anomalies (DVA) are among the most common congenital malformations of the cerebral angioarchitecture. Spontaneous thrombosis of this entity is rare, and our review of the literature found only 31 reported cases of symptomatic spontaneous thrombosis of developmental venous anomalies. Here, we report a unique case describing the spontaneous thrombosis of a DVA leading to venous infarction and subsequent recanalization. The patient was a previously healthy 21-year-old male who presented with an acute onset of partial seizures...
2015: Curēus
Marcelo M Serra, Bruno L Ferreyro, Oscar Peralta, Ezequiel Levy Yeyati, Natalia Causada Calo, Teresa Garcia-Botta, Diego Andresik, Martín Rabellino, Ricardo Garcia-Mónaco
Hereditary hemorrhagic telangiectasia (HHT) usually presents in association with pulmonary arteriovenous malformations (PAVMs). In addition, the incidence of venous thromboembolism tends to be increased in these patients. A 74-year-old female with HHT presented with cyanosis and hypoxemia. Contrast-enhanced multislice computed tomography (MSCT) revealed two left PAVMs and one in the right upper lobe. Both left PAVMs were treated with embolotherapy. Follow-up MSCT revealed an incidental pulmonary embolism in the right pulmonary branches...
2015: Internal Medicine
Massimiliano Visocchi, Giuseppe La Rocca, Francesco Signorelli, Romeo Roselli, Zhong Jun, A Spallone
INTRODUCTION: Spontaneous idiopathic acute spinal subdural hematoma (SSDH) is a rare cause of acute back pain followed by signs and symptoms of nerve root and/or spinal cord compression, frequently associated with coagulopathies, blood dyscrasias and arterio-venous malformations. Standard management includes non-operative treatment and timely (within 24h) surgical decompression. PRESENTATION OF CASE: We report on the case of a huge 10 levels SSDH treated with decompressive thoracic no-instrumented laminectomy in a 45-year-old woman with good neurological recovery (from ASIA A to D)...
2015: International Journal of Surgery Case Reports
M Hoeltzenbein, E Beck, K Meixner, C Schaefer, R Kreutz
BACKGROUND: New oral anticoagulants are increasingly used in women of childbearing age, but apart from one case report there is no published experience with rivaroxaban exposure during pregnancy. METHODS: From October 2008 to December 2014, the German Embryotox Pharmacovigilance Centre identified 63 exposed pregnancies among 94 requests concerning rivaroxaban use during childbearing age. Follow-up included paediatric checks until 6 weeks after birth. RESULTS: All pregnancies with completed follow-up were exposed at least during the first trimester...
February 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Kevin S H Koo, Christopher F Dowd, Erin F Mathes, Kristina W Rosbe, William Y Hoffman, Ilona J Frieden, Christopher P Hess
BACKGROUND: The incidence of localized intravascular coagulopathy (LIC) in venous malformations varies with lesion size and location, as well as the presence of palpable phleboliths. The development of LIC can cause pain and hemorrhage and can progress to disseminated intravascular coagulopathy (DIC) and thromboembolic disease resulting in death in some cases. Early recognition of LIC can relieve symptoms and prevent progression to life-threatening complications. OBJECTIVE: The aim of this work was to identify MRI features of venous malformation associated with LIC...
October 2015: Pediatric Radiology
A Fekir, X Balguerie, I Bardoux, J-N Dacher, P-H Vivier
Venous malformation (VM) is a frequent soft tissue mass in children that should not be confused with vascular tumors. We report the case of a 10-year-old boy with a bulky thrombosed VM of the shoulder with functional disability. D-dimer levels were high. Pathognomonic phleboliths were demonstrated on conventional x-rays. Echo-doppler confirmed the venous nature of the lesion and areas without flow suspicious for thrombosis. MRI provides the deep extension and can show non-calcified thrombi that are difficult to see with ultrasound...
July 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Morinobu Seki, Mamoru Shibata, Yoshiaki Itoh, Norihiro Suzuki
BACKGROUND: Nowadays, developmental venous anomaly (DVA) is recognized as the most common cerebral vascular malformation. Most DVAs are diagnosed incidentally on routine brain imaging, but they are occasionally symptomatic. We report the case of a 26-year-old Japanese woman with intracerebral hemorrhage due to venous thrombosis of DVA. METHODS: We examined her neurologic examinations carefully. We also observed her laboratory data, brain computed tomography (CT), and magnetic resonance imaging (MRI) findings...
July 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Christopher Dittus, Michael Streiff, Jack Ansell
Hereditary hemorrhagic telangiectasia (HHT) is a relatively common inherited vascular disorder that was first described in 1864, and is notable for epistaxis, telangiectasia, and arterial venous malformations. While genetic tests are available, the diagnosis remains clinical, and is based on the Curacao criteria. Patients with HHT are at increased risk for both bleeding and clotting events. Because of these competing complications, hematologists are often faced with difficult clinical decisions. While the majority of management decisions revolve around bleeding complications, it is not infrequent for these patients to require anticoagulation for thrombosis...
April 16, 2015: World Journal of Clinical Cases
Ami M Karkar, Manuel R Castresana, Nadine Odo, Shvetank Agarwal
Thromboembolism continues to be a major concern in patients with mechanical heart valves, especially in those with unsatisfactory anticoagulation levels. The new On-X valve (On-X Life Technologies, Austin, TX, USA) has been reported as having unique structural characteristics that offer lower thrombogenicity to the valve. We report a case where the patient received no or minimal systemic anticoagulation after placement of On-X mitral and aortic valves due to development of severe mucosal arterio-venous malformations yet did not show any evidence of thromboembolism...
April 2015: Annals of Cardiac Anaesthesia
Chao Jiang, Wei Ye, Changwei Liu, Weiwei Wu, Yongjun Li
The purpose of this study was to report the use of venous pressure measurement during surgery for Abernethy malformation (AF). This is a case report of a 19-year-old man who suffered from hematuria and hemafecia for 3 months with worsening symptoms a week before being sent to the emergency room. He was diagnosed with type II AF based on portal phlebography. We performed an open surgery; measured portal vein, inferior mesenteric vein (IMV), and inferior vena cava pressure; and decided to completely suture the IMV...
July 2015: Annals of Vascular Surgery
Pouria Parsa, John S Lane, Andrew R Barleben, Erik L Owens, Dennis Bandyk
Congenital anomalies of the inferior vena cava (IVC), although rare, are a risk factor for lower limb deep venous thrombosis (DVT). A 19-year-old male presented with a left flank and groin pain caused by iliofemoral venous thrombosis. Vascular imaging by computed tomography (CT) scanning and venography demonstrated agenesis of the IVC. Catheter-directed thrombolysis via a popliteal vein was attempted but did not alter the patency of the common femoral vein outflow collaterals into the retroperitoneal azygous venous system...
July 2015: Annals of Vascular Surgery
Fadi I Jabr, Nedaa Skeik
Klippel-Trenaunay syndrome (KTS) is a capillary-venous vascular malformation condition characterized by capillary malformation, soft tissue and bone hypertrophy, and varicosities. Here we present the case of a 29-year-old man who presented with port wine stain and recurrent ulcerations on his right leg. This leg was also larger than the left one. His condition was consistent with KTS. We discuss the pathogenesis, clinical presentation, complications, and treatment modalities of KTS.
November 2014: Postgraduate Medicine
Brooke M Lamparello, Cameron R Erickson, Arun Kulthia, Vasudev Virparia, Zeyar Thet
A previously healthy 21-year-old man presented with back pain, bilateral extremity pain, and right lower extremity weakness, paresthesias, and swelling. Sonographic examination revealed diffuse deep vein thrombosis (DVT) in the femoral and popliteal venous system. CT imaging revealed hypoplasia of the hepatic inferior vena cava (IVC) segment with formation of multiple varices and collateral veins around the kidneys. Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT...
2014: Vascular Health and Risk Management
Laura Londra, Kyle Tobler, John Wu, Lisa Kolp
Precis. The postoperative course of a neovagina creation procedure in a young woman with Meyer-Rokitansky-Kuster-Hauser syndrome was complicated, despite prophylaxis, by extensive pelvic deep venous thrombosis secondary to unsuspected severe inferior vena cava stenosis. Background. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by congenital vaginal agenesis and an absent or rudimentary uterus in genotypical females. Malformations of the inferior vena cava (IVC) are not commonly associated with MRKH syndrome...
2014: Case Reports in Obstetrics and Gynecology
F Puccinelli, K Deiva, C Bellesme, P Durand, L Chevret, B Husson, M Sachet, D Ducreux, G Saliou
PURPOSE: Thrombosis of cerebral arteriovenous malformation after embolization is rare, but can involve the normal venous network with extensive venous thrombosis. We report angioarchitecture findings, our management and prevention strategy for this complication in pediatric AVMs. METHODS: In this 5.5-year retrospective series, we reviewed records of 13 patients under 15 years who were anticoagulated after embolization. In our initial experience 4 children who didn't receive any prophylactic anticoagulation presented with extensive venous thrombosis after embolization (group 1)...
November 2014: European Journal of Paediatric Neurology: EJPN
Jennifer T Nguyen, Marion A Koerper, Christopher P Hess, Christopher F Dowd, William Y Hoffman, Meghan Dickman, Ilona J Frieden
Venous malformations (VMs) are often painful and may enlarge over time. Chronic coagulopathy is common in VMs and may contribute to phleboliths and potentially to disease progression. Few studies have examined the effects of anticoagulation on VMs and to our knowledge none have examined the use of aspirin therapy. A survey was administered to patients and parents of patients with VMs who attended the University of California at San Francisco Vascular Anomalies Center over a 4-year period (2008-2012) to whom aspirin had been recommended...
September 2014: Pediatric Dermatology
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