keyword
https://read.qxmd.com/read/38455473/lessons-learned-spanning-17%C3%A2-years-of-experience-with-three-consecutive-nationwide-competency-based-medical-education-training-plans
#21
JOURNAL ARTICLE
Merel H de Heer, Erik W Driessen, Pim W Teunissen, Fedde Scheele
INTRODUCTION: Curricula for postgraduate medical education have transformed since the introduction of competency based medical education (CBME). Postgraduate training plans offer broader training with different competencies and an outcome-based approach, in addition to the medical technical aspects of training. However, CBME also has its challenges. Over the past years, critical views have been shared on the potential drawbacks of CBME, such as assessment burden and conflicts with practicality in the workplace...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38453405/deprescribing-in-older-patients-with-advanced-cancer-referred-to-palliative-care
#22
JOURNAL ARTICLE
Jorge Fernández-Fradejas, Hilario Martínez-Barros, Lourdes Rexach-Cano, Ana María Álvarez-Díaz, Eva Delgado-Silveira
OBJECTIVES: This study aimed to explore the prevalence of potentially inappropriate medications (PIMs) in a cohort of older adults with advanced cancer referred to palliative care. Secondary objectives were to describe the categories of identified PIMs and assess risk factors associated with their presence in this population. METHODS: This retrospective, observational study evaluated patients with advanced cancer admitted to a tertiary university hospital in Madrid, Spain and referred to palliative care between 1 January 2020 and 30 June 2020...
March 7, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38448738/aso-author-reflections-surgical-strategy-for-perihilar-cholangiocarcinoma
#23
JOURNAL ARTICLE
Pim B Olthof, Bas Groot Koerkamp
No abstract text is available yet for this article.
March 6, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38444665/the-relationship-of-fat-and-muscle-measurements-with-emphysema-and-bronchial-wall-thickening-in-smokers
#24
JOURNAL ARTICLE
Stijn A O Bunk, Jetty Ipema, Grigory Sidorenkov, Edwin Bennink, Rozemarijn Vliegenthart, Pim A de Jong, Esther Pompe, Jean-Paul Charbonnier, Bart H D Luijk, Joachim Aerts, Harry J M Groen, Firdaus A A Mohamed Hoesein
INTRODUCTION: Differences in body composition in patients with COPD may have important prognostic value and may provide opportunities for patient-specific management. We investigated the relation of thoracic fat and muscle with computed tomography (CT)-measured emphysema and bronchial wall thickening. METHODS: Low-dose baseline chest CT scans from 1031 male lung cancer screening participants from one site were quantified for emphysema, bronchial wall thickening, subcutaneous fat, visceral fat and skeletal muscle...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38444545/what-is-the-association-of-polypharmacy-with-frailty-in-heart-failure-a-systematic-review-and-meta-analysis
#25
REVIEW
Konstantinos Prokopidis, Giuseppe Dario Testa, Nicola Veronese, Yannis Dionyssiotis, Joseph McLean, Lauren E Walker, Rajiv Sankaranarayanan
This systematic review and meta-analysis aimed to explore the differences in the number of prescribed medications and polypharmacy risk between patients with heart failure (HF) and frailty vs. those with HF but without frailty. Eligible studies included observational or experimental studies in patients aged ≥50 years. Thirteen studies met the criteria and were included in the final analysis. Patients with frailty and HF exhibited a higher risk of polypharmacy (OR: 1.87, 95% CI 1.72 - 2.04, I2 = 0%, P < 0...
March 2024: Journal of frailty, sarcopenia and falls
https://read.qxmd.com/read/38441286/multifunctional-umbrella-in-situ-interface-film-forming-on-the-high-voltage-licoo-2-cathode-by-a-tiny-amount-of-nanoporous-polymer-additives-for-high-energy-density-li-ion-batteries
#26
JOURNAL ARTICLE
Ruoxuan Qi, Ming Yang, Tianle Zheng, Xingchen Liu, Yonggao Xia, Ya-Jun Cheng, Peter Müller-Buschbaum
The LiCoO2 (LCO) cathode is foreseen for extensive commercial applications owing to its high specific capacity and stability. Therefore, there is considerable interest in further enhancing its specific capacity by increasing the charging voltage. However, single-crystal LCO suffers from a significant capacity degradation when charged to 4.5 V due to the irreversible phase transition and unstable structure. Herein, an ultra-small amount (0.5% wt. in the electrode) of multi-functional PIM-1 (a polymer with intrinsic microporosity) additive is utilized to prepare a kind of binder-free electrode...
March 5, 2024: Small
https://read.qxmd.com/read/38439715/dna-methylation-heterogeneity-attributable-to-a-complex-tumor-immune-microenvironment-prompts-prognostic-risk-in-glioma
#27
JOURNAL ARTICLE
Shuangyue Ma, Xu Pan, Jing Gan, Xiaxin Guo, Jiaheng He, Haoyu Hu, Yuncong Wang, Shangwei Ning, Hui Zhi
Gliomas are malignant tumours of the human nervous system with different World Health Organization (WHO) classifications, glioblastoma (GBM) with higher grade and are more malignant than lower-grade glioma (LGG). To dissect how the DNA methylation heterogeneity in gliomas is influenced by the complex cellular composition of the tumour immune microenvironment, we first compared the DNA methylation profiles of purified human immune cells and bulk glioma tissue, stratifying three tumour immune microenvironmental subtypes for GBM and LGG samples from The Cancer Genome Atlas (TCGA)...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/38437312/stress-analysis-of-a-large-diameter-aspheric-plastic-lens-in-the-variable-temperature-assisted-injection-molding-process
#28
JOURNAL ARTICLE
Longfei Wang, Yuwang Hu, Changxi Xue
The technology known as precision injection molding (PIM) has shown great promise in the large-scale manufacturing of optical plastic lenses. The primary challenge with the PIM process is accurately predicting and reducing residual stress in optical plastic lenses. In this work, the finite element method (FEM) was used to analyze the residual stress distribution in plastic lenses. A three-dimensional model was created using COMSOL software to investigate how residual stress and temperature varied in optical plastic lenses during the packing and cooling stages...
February 10, 2024: Applied Optics
https://read.qxmd.com/read/38436221/ultramicroporous-tr%C3%A3-ger-s-base-framework-membranes-for-ph-neutral-aqueous-organic-redox-flow-batteries
#29
JOURNAL ARTICLE
Junmin Liu, Wenyi Wu, Peipei Zuo, Zhengjin Yang, Tongwen Xu
Processable polymers of intrinsic microporosity (PIMs) are emerging as promising candidates for next-generation ion exchange membranes (IEMs). However, especially with high ion exchange capacity (IEC), IEMs derived from PIMs suffer from severe swelling, thus, resulting in decreased selectivity. To solve this problem, we report ultramicroporous polymer framework membranes constructed with rigid Tröger's Base network chains, which are fabricated via an organic sol-gel process. These membranes demonstrate excellent antiswelling, with swelling ratios below 4...
March 4, 2024: ACS Macro Letters
https://read.qxmd.com/read/38435818/hydraulic-conductivity-of-human-cancer-tissue-a-hybrid-study
#30
JOURNAL ARTICLE
Hooman Salavati, Pim Pullens, Charlotte Debbaut, Wim Ceelen
BACKGROUND: Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and an aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IFP non-invasively. Image-based estimation of the IFP requires knowledge of the tissue hydraulic conductivity ( K ), a measure for the ease of bulk flow through the interstitium. However, data on the magnitude of K in human cancer tissue are not available...
March 2024: Bioengineering & Translational Medicine
https://read.qxmd.com/read/38435679/molecular-mobility-and-gas-transport-properties-of-mixed-matrix-membranes-based-on-pim-1-and-a-phosphinine-containing-covalent-organic-framework
#31
JOURNAL ARTICLE
Farnaz Emamverdi, Jieyang Huang, Negar Mosane Razavi, Michael J Bojdys, Andrew B Foster, Peter M Budd, Martin Böhning, Andreas Schönhals
Polymers with intrinsic microporosity (PIMs) are gaining attention as gas separation membranes. Nevertheless, they face limitations due to their pronounced physical aging. In this study, a covalent organic framework containing λ5 -phosphinine moieties, CPSF-EtO, was incorporated as a nanofiller (concentration range 0-10 wt %) into a PIM-1 matrix forming dense films with a thickness of ca. 100 μm. The aim of the investigation was to investigate possible enhancements of gas transport properties and mitigating effects on physical aging...
February 27, 2024: Macromolecules
https://read.qxmd.com/read/38435445/potentially-inappropriate-medication-prescribing-based-on-2019-beers-criteria-and-the-impact-of-pharmacist-intervention-in-elderly-patients-with-kidney-diseases-a-report-from-iran
#32
JOURNAL ARTICLE
Yasaman Nader Babaei, Zahra Niazkhani, Khadijeh Makhdoomi, Ayda Esmaeili
BACKGROUND AND AIMS: A potentially inappropriate medication (PIM) is a pharmaceutical agent that poses a greater risk of harm than potential benefit to elderly patients. This study aimed to detect PIMs and their risk factors in hospitalized elderly patients with kidney disease. METHODS: This cross-sectional study assessed medication orders of elderly patients (≥65 years old) with kidney diseases admitted to the hospital. In the first 6 months, we retrospectively evaluated all medications to identify PIMs according to the 2019 Beers criteria...
March 2024: Health Science Reports
https://read.qxmd.com/read/38434703/evaluation-of-medication-safety-assessment-tools-for-pharmacist-led-medication-reviews-the-eastern-european-pilot-project
#33
JOURNAL ARTICLE
Anita Tuula, Piotr Merks, Magdalena Waszyk-Nowaczyk, Mariola Drozd, Galina Petrova, Reka Viola, Veera Bobrova, Michael Scott, Marje Oona, Daisy Volmer
Background: Pharmacist-led medication reviews (MR) are one of the key methods to support medication safety in polypharmacy patients. The aims of this study were to pilot MRs in Eastern European community pharmacies, describe medication use in polypharmacy patients, and evaluate the usability of medication safety assessment tools. Methods: The MR pilot was undertaken in Estonia, Latvia, Poland, Hungary, Romania, and Bulgaria. Patients who used at least five medicines were directed to the service by their GPs...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38432584/current-state-of-covid-19-in-children-4-years-on
#34
REVIEW
Annabel A Powell, Alexander C Dowell, Paul Moss, Shamez N Ladhani
Children have been disproportionately affected by the COVID-19 pandemic. Despite evidence of a very low risk of severe disease, children were subjected to extensive lockdown, restriction and mitigation measures, including school closures, to control the rapid spread of SARS-CoV-2 in most parts of the world. In this review we summarise the UK experience of COVID-19 in children four years into the largest and longest pandemic of this century. We address the risks of SARS-CoV-2 infection, immunity, transmission, severity and outcomes in children...
March 1, 2024: Journal of Infection
https://read.qxmd.com/read/38428480/post-covid-19-condition-imposes-significant-burden-in-patients-with-advanced-chronic-kidney-disease-a-nested-case-control-study
#35
JOURNAL ARTICLE
Pim Bouwmans, S Reshwan K Malahe, A Lianne Messchendorp, Priya Vart, Céline Imhof, Jan-Stephan Sanders, Ron T Gansevoort, Aiko P J de Vries, Alferso C Abrahams, Frederike J Bemelman, Johanna P M Vervoort, Luuk Hilbrands, Marc A G J Ten Dam, René M A van den Dorpel, Theo Rispens, Maurice Steenhuis, Marlies E J Reinders, Marc H Hemmelder
BACKGROUND: The burden of post COVID-19 condition (PCC) is not well studied in patients with advanced kidney disease. METHODS: A large prospective cohort of SARS-CoV-2 vaccinated patients with chronic kidney disease stages G4-G5 (CKD G4/5), on dialysis, and kidney transplant recipients (KTR) were included. Antibody levels were determined after vaccination. Presence of long-lasting symptoms was assessed in patients with and without prior COVID-19 and compared using logistic regression...
February 28, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38428438/assessment-of-suicidality-in-trials-of-psychological-interventions-for-depression-a-meta-analysis
#36
JOURNAL ARTICLE
Clara Miguel, Jessica Cecconi, Mathias Harrer, Wouter van Ballegooijen, Shalini Bhattacharya, Eirini Karyotaki, Pim Cuijpers, Claudio Gentili, Ioana A Cristea
BACKGROUND: Psychological interventions that are efficacious as treatments for depression could indirectly affect suicide-related outcomes. We examined suicidal thoughts and behaviours as eligibility criteria, outcomes, and adverse events across trials of psychotherapy for depression. METHODS: We used a publicly available meta-analytic database developed through systematic searches (updated as of May 1, 2023) to identify randomised controlled trials in which a psychological intervention for depression was compared with an inactive or non-specific control condition in adults with depression and in which any suicide-related outcomes were reported...
February 27, 2024: Lancet Psychiatry
https://read.qxmd.com/read/38426079/imaging-of-intracranial-arterial-disease-a-comparison-between-mri-and-unenhanced-ct
#37
JOURNAL ARTICLE
Carlo Lucci, Ina Rissanen, Richard A P Takx, Anja G van der Kolk, Anita A Harteveld, Jan W Dankbaar, Mirjam I Geerlings, Pim A de Jong, Jeroen Hendrikse
BACKGROUND AND PURPOSE: Arterial calcifications on unenhanced CT scans and vessel wall lesions on MRI are often used interchangeably to portray intracranial arterial disease. However, the extent of pathology depicted with each technique is unclear. We investigated the presence and distribution of these two imaging findings in patients with a history of cerebrovascular disease. MATERIALS AND METHODS: We analyzed CT and MRI data from 78 patients admitted for stroke or TIA at our institution...
2024: Front Radiol
https://read.qxmd.com/read/38424411/development-of-personalized-non-invasive-ventilation-masks-for-critically-ill-children-a-bench-study
#38
JOURNAL ARTICLE
Rosemijne R W P Pigmans, Rozalinde Klein-Blommert, Monica C van Gestel, Dick G Markhorst, Peter Hammond, Pim Boomsma, Tim Daams, Julia M A de Jong, Paul M Heeman, Job B M van Woensel, Coen D Dijkman, Reinout A Bem
BACKGROUND: Obtaining a properly fitting non-invasive ventilation (NIV) mask to treat acute respiratory failure is a major challenge, especially in young children and patients with craniofacial abnormalities. Personalization of NIV masks holds promise to improve pediatric NIV efficiency. As current customization methods are relatively time consuming, this study aimed to test the air leak and surface pressure performance of personalized oronasal face masks using 3D printed soft materials...
March 1, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38424303/a-promising-natural-product-in-diffuse-large-b-cell-lymphoma-therapy-by-targeting-pim1
#39
JOURNAL ARTICLE
Xinyun Zhang, Qi Su, Yuchen Zhang, Rong Rong, Si Chen, Lexin He, Wenzhuo Zhuang, Bingzong Li
Diffuse large B-cell lymphoma (DLBCL) is the most common and aggressive type of B-cell lymphoma. Unfortunately, about one-third of patients either relapse after the initial treatment or are refractory to first-line therapy, indicating a need for new treatment modalities. PIM serine/threonine kinases are proteins that are associated with genetic mutations, overexpression, or translocation events in B-cell lymphomas. We conducted an integrative analysis of whole-exome sequencing in 52 DLBCL patients, and no amplification, mutation, or translocation of the PIM1 gene was detected...
March 1, 2024: Annals of Hematology
https://read.qxmd.com/read/38423751/preventing-hip-osteoarthritis-in-athletes-is-it-really-a-mission-impossible
#40
EDITORIAL
Joshua J Heerey, Pim van Klij, Rintje Agricola, Hendrik P Dijkstra, Lindsey Plass, Kay M Crossley, Joanne L Kemp
No abstract text is available yet for this article.
February 29, 2024: British Journal of Sports Medicine
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