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https://www.readbyqxmd.com/read/29333859/chromatographic-separation-and-visual-detection-on-wicking-microfluidic-devices-quantitation-of-cu2-in-surface-ground-and-drinking-water
#1
Gayan C Bandara, Christopher Heist, Vincent T Remcho
Copper is widely applied in industrial and technological applications, and is an essential micro nutrient for humans and animals. However, exposure to high environmental levels of copper, especially through drinking water, can lead to copper toxicity, resulting in severe acute and chronic health effects. Therefore, regular monitoring of aqueous copper ions has become necessary as recent anthropogenic activities have led to elevated environmental concentrations of copper. On-site monitoring processes require an inexpensive, simple, and portable analytical approach capable of generating reliable qualitative and quantitative data efficiently...
January 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29331596/problem-solving-therapy-for-adult-depression-an-updated-meta-analysis
#2
Pim Cuijpers, Leonore de Wit, Annet Kleiboer, Eirini Karyotaki, David D Ebert
BACKGROUND: Problem-solving therapy (PST) is one of the best examined types of psychotherapy for adult depression. No recent meta-analysis has examined the effects of PST compared to control groups or to other treatments. We wanted to verify whether PST is effective, whether effects are comparable to those of other treatments, and whether we could identify the possible sources of high heterogeneity that was found in earlier meta-analyses. METHODS: We conducted systematic searches in bibliographical databases, including PubMed, PsycInfo, Embase and the Cochrane database of randomized trials...
December 8, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29330983/ultrasound-and-supine-chest-radiograph-in-road-traffic-accident-patients-a-reliable-and-convenient-way-to-diagnose-pleural-effusion
#3
Uzma Mumtaz, Zainab Zahur, Muhammad Ali Raza, Madiha Mumtaz
BACKGROUND: Portable bed side ultrasound and supine chest radiograph of 80 traumatic patients excluding very clinically unstable patients who subsequently underwent CT scan chest was done for traumatic effusion showing that ultrasound had a higher sensitivity than CXR, 88.23% and 77.94%, respectively, and a similar specificity of 100% and 100%, respectively. Objective of the study is to compare the diagnostic accuracy of high resolution ultrasound and supine chest x-ray in detection of pleural effusion in road traffic accident patients keeping plain CT chest as gold standard...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29330585/potentially-inappropriate-medications-in-community-dwelling-older-adults-undertaken-as-a-comprehensive-geriatric-risk-assessment
#4
Sharmin S Bala, Sujita W Narayan, Prasad S Nishtala
PURPOSE: The prescription of potentially inappropriate medications (PIMs) is associated with an increase in adverse events, prescribing cascades, high health-care costs, morbidity, and mortality in the elderly. The overarching objective of this study is to examine the prevalence of PIMs in the elderly, applying the 2012 American Geriatrics Society Beers criteria for the study period 2012-2014, and the updated 2015 Beers criteria for 2015. METHODS: The study population (N = 70,479) included a continuously recruited national cohort of community-dwelling older (aged ≥ 65 years) New Zealanders who had undertaken the International Resident Assessment Instrument-Home Care (interRAI-HC) assessments between September 2012 and October 2015...
January 12, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29329486/cost-effectiveness-of-guided-internet-based-interventions-for-depression-in-comparison-with-control-conditions-an-individual-participant-data-meta-analysis
#5
REVIEW
Spyros Kolovos, Johanna M van Dongen, Heleen Riper, Claudia Buntrock, Pim Cuijpers, David D Ebert, Anna S Geraedts, Robin M Kenter, Stephanie Nobis, Andrea Smith, Lisanne Warmerdam, Jill A Hayden, Maurits W van Tulder, Judith E Bosmans
BACKGROUND: There is limited evidence on the cost effectiveness of Internet-based treatments for depression. The aim was to evaluate the cost effectiveness of guided Internet-based interventions for depression compared to controls. METHODS: Individual-participant data from five randomized controlled trials (RCT), including 1,426 participants, were combined. Cost-effectiveness analyses were conducted at 8 weeks, 6 months, and 12 months follow-up. RESULTS: The guided Internet-based interventions were more costly than the controls, but not statistically significant (12 months mean difference = €406, 95% CI: - 611 to 1,444)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29328537/deracemization-of-a-racemic-compound-using-tailor-made-additives
#6
Ton Engwerda, Pim van Schayik, Henjo Jagtenberg, Hugo Meekes, Floris P J T Rutjes, Elias Vlieg
Viedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution phase racemization, resulting in solid phase deracemization. One of the major disadvantages of Viedma ripening is that the desired compound needs to crystallize as a racemic conglomerate, accounting for only 5-10% of all chiral molecules. In this work, we show that use of a chiral additive causes deracemization under conditions in which the compound normally crystallizes as a racemic compound. Although this concerns a single example, it is envisioned that through this new approach the scope of Viedma ripening can be significantly expanded...
January 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29327797/potassium-and-the-use-of-renin-angiotensin-aldosterone-system-inhibitors-in-heart-failure-with-reduced-ejection-fraction-data-from-biostat-chf
#7
Joost C Beusekamp, Jasper Tromp, Haye H van der Wal, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Pim van der Harst, Hans L Hillege, Chim C Lang, Marco Metra, Leong L Ng, Piotr Ponikowski, Nilesh J Samani, Dirk J van Veldhuisen, Aeilko H Zwinderman, Patrick Rossignol, Faiez Zannad, Adriaan A Voors, Peter van der Meer
BACKGROUND: Hyperkalaemia is a common co-morbidity in patients with heart failure with reduced ejection fraction (HFrEF). Whether it affects the use of renin-angiotensin-aldosterone system inhibitors and thereby negatively impacts outcome is unknown. Therefore, we investigated the association between potassium and uptitration of angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) and its association with outcome. METHODS AND RESULTS: Out of 2516 patients from the BIOSTAT-CHF study, potassium levels were available in 1666 patients with HFrEF...
January 12, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29327347/unique-anti-myeloma-activity-by-thiazolidine-2-4-dione-compounds-with-pim-inhibiting-activity
#8
Shiro Fujii, Shingen Nakamura, Asuka Oda, Hirokazu Miki, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Yusaku Maeda, Masahiro Oura, Mamiko Takahashi, Masami Iwasa, Itsuro Endo, Sumiko Yoshida, Ken-Ichi Aihara, Kiyoe Kurahashi, Takeshi Harada, Kumiko Kagawa, Michiyasu Nakao, Shigeki Sano, Masahiro Abe
Proviral Integrations of Moloney virus 2 (PIM2) is overexpressed in multiple myeloma (MM) cells, and regarded as an important therapeutic target. Here, we aimed to validate the therapeutic efficacy of different types of PIM inhibitors against MM cells for their possible clinical application. Intriguingly, the thiazolidine-2,4-dione-family compounds SMI-16a and SMI-4a reduced PIM2 protein levels and impaired MM cell survival preferentially in acidic conditions, in contrast to other types of PIM inhibitors, including AZD1208, CX-6258 and PIM447...
January 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29325531/costs-of-potentially-inappropriate-medication-use-in-residential-aged-care-facilities
#9
S L Harrison, L Kouladjian O'Donnell, R Milte, S M Dyer, E S Gnanamanickam, C Bradley, E Liu, S N Hilmer, M Crotty
BACKGROUND: The potential harms of some medications may outweigh their potential benefits (inappropriate medication use). Despite recommendations to avoid the use of potentially inappropriate medications (PIMs) in older adults, the prevalence of PIM use is high in different settings including residential aged care. However, it remains unclear what the costs of these medications are in this setting. The main objective of this study was to determine the costs of PIMs in older adults living in residential care...
January 11, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29322475/the-scope-of-drug-related-problems-in-the-home-care-setting
#10
REVIEW
Carla Meyer-Massetti, Christoph R Meier, B Joseph Guglielmo
Introduction While drug-related problems (DRPs) in the inpatient setting are well known, the scope of these problems in home care has not been critically evaluated. Aim of the Review Our primary objective was to evaluate the incidence and demographics of DRPs in home care. Our specific aims were to characterize the rate of potentially inappropriate medications (PIMs), medication errors (MEs) and adverse drug events (ADEs) and to identify risk factors which contribute to DRPs in the home care setting. Methods Pubmed, Embase and CiNAHL databases were systematically searched from January 2000 to December 2016 for all publications which quantitatively characterized DRPs in the home care setting...
January 11, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29322198/association-of-cardiovascular-biomarkers-with-incident-heart-failure-with-preserved-and-reduced-ejection-fraction
#11
Rudolf A de Boer, Matthew Nayor, Christopher R deFilippi, Danielle Enserro, Vijeta Bhambhani, Jorge R Kizer, Michael J Blaha, Frank P Brouwers, Mary Cushman, Joao A C Lima, Hossein Bahrami, Pim van der Harst, Thomas J Wang, Ron T Gansevoort, Caroline S Fox, Hanna K Gaggin, Willem J Kop, Kiang Liu, Ramachandran S Vasan, Bruce M Psaty, Douglas S Lee, Hans L Hillege, Traci M Bartz, Emelia J Benjamin, Cheeling Chan, Matthew Allison, Julius M Gardin, James L Januzzi, Sanjiv J Shah, Daniel Levy, David M Herrington, Martin G Larson, Wiek H van Gilst, John S Gottdiener, Alain G Bertoni, Jennifer E Ho
Importance: Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart failure subtype are incompletely understood. Objective: To evaluate the associations of 12 cardiovascular biomarkers with incident HFpEF vs HFrEF among adults from the general population. Design, Setting, and Participants: This study included 4 longitudinal community-based cohorts: the Cardiovascular Health Study (1989-1990; 1992-1993 for supplemental African-American cohort), the Framingham Heart Study (1995-1998), the Multi-Ethnic Study of Atherosclerosis (2000-2002), and the Prevention of Renal and Vascular End-stage Disease study (1997-1998)...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29321327/human-papillomavirus-16-infection-induces-vap-dependent-endosomal-tubulation
#12
Abida Siddiqa, Paola Massimi, David Pim, Justyna Broniarczyk, Lawrence Banks
Human Papillomavirus (HPV) infection involves complex interactions with the endocytic transport machinery, which ultimately facilitates the entry of the incoming viral genomes into the trans-Golgi network and their subsequent nuclear entry during mitosis. The endosomal pathway is a highly dynamic intracellular transport system, which consists of vesicular compartments and tubular extensions, although it is currently unclear whether incoming viruses specifically alter the endocytic machinery. In this study, using MICAL-L1 as a marker for tubulating endosomes, we show that incoming HPV-16 virions induce a profound alteration in global levels of endocytic tubulation...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29320482/severe-retinopathy-of-prematurity-is-associated-with-reduced-cerebellar-and-brainstem-volumes-at-term-and-neurodevelopmental-deficits-at-two-years
#13
Femke J Drost, Kristin Keunen, Pim Moeskops, Nathalie H P Claessens, Femke van Kalken, Ivana Išgum, Elsbeth S M Voskuil-Kerkhof, Floris Groenendaal, Linda S de Vries, Manon J N L Benders, Jacqueline U M Termote
OBJECTIVE: To evaluate the association between severe retinopathy of prematurity (ROP), measures of brain morphology at term equivalent age (TEA) and neurodevelopmental outcome. PATIENTS AND METHODS: 18 infants with severe ROP (median gestational age (GA) 25.3 (range 24.6-25.9 weeks) were included in this retrospective case-control study. Each infant was matched to two extremely preterm control infants (n=36) by GA, birth weight, sex and brain injury. T2-weighted images were obtained on a 3T MRI at TEA...
January 10, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29314007/chlorophyll-fluorescence-imaging-reveals-genetic-variation-and-loci-for-a-photosynthetic-trait-in-diploid-potato
#14
Aina E Prinzenberg, Marcela Víquez-Zamora, Jeremy Harbinson, Pim Lindhout, Sjaak van Heusden
Physiology and genetics are tightly interrelated. Understanding the genetic basis of a physiological trait such as the quantum yield of the photosystem II, or photosynthetic responses to environmental changes will benefit the understanding of these processes. By means of chlorophyll fluorescence imaging "CF", the quantum yield of photosystem II can be determined rapidly, precisely and non-invasively. In this article, the genetic control and variation in the steady-state quantum yield of PSII "ΦPSII " is analysed for diploid potato plants...
January 4, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29310282/use-of-polymer-inclusion-membranes-pims-as-support-for-electromembrane-extraction-of-non-steroidal-anti-inflammatory-drugs-and-highly-polar-acidic-drugs
#15
Román-Hidalgo Cristina, Martín-Valero María Jesús, Fernández-Torres Rut, Bello-López Miguel Ángel
The use of polymer inclusion membranes (PIMs) as support of 1-octanol liquid membrane in electromembrane extraction (EME) procedure is proposed. Synthesis of PIMs were optimized to a composition of 29% (w/w) of cellulose triacetate as base polymer and 71% (w/w) of Aliquat®336 as cationic carrier. Flat PIMs of 25µm thickness and 6mm diameter were used. EME protocol was implemented for the simultaneous extraction of four non-steroidal anti-inflammatory drugs (NSAIDs) (salicylic acid, ketoprofen, naproxen and ibuprofen) and four highly polar acidic drugs (anthranilic acid, nicotinic acid, amoxicillin and hippuric acid)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29306953/no-sustainable-effects-of-an-internet-based-relapse-prevention-program-over-24-months-in-recurrent-depression-primary-outcomes-of-a-randomized-controlled-trial
#16
Nicola S Klein, Gemma D Kok, Huibert Burger, Evelien van Valen, Heleen Riper, Pim Cuijpers, Jack Dekker, Filip Smit, Colin van der Heiden, Claudi L H Bockting
No abstract text is available yet for this article.
January 6, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29306886/comparative-efficacy-and-tolerability-of-new-generation-antidepressants-for-major-depressive-disorder-in-children-and-adolescents-protocol-of-an-individual-patient-data-meta-analysis
#17
Xinyu Zhou, Andrea Cipriani, Toshi A Furukawa, Pim Cuijpers, Yuqing Zhang, Sarah E Hetrick, Juncai Pu, Shuai Yuan, Cinzia Del Giovane, Peng Xie
INTRODUCTION: Although previous conventional meta-analyses and network meta-analyses have provided some important findings about pharmacological treatments for children and adolescents with depressive disorders in the past decades, several questions still remain unsolved by the aggregate data from those meta-analyses. Individual participant data meta-analysis (IPD-MA) enables exploration of the impacts of individual characteristics on treatment effects, allowing matching of treatments to specific subgroups of patients...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306478/fibroblast-growth-factor-23-is-related-to-profiles-indicating-volume-overload-poor-therapy-optimization-and-prognosis-in-patients-with-new-onset-and-worsening-heart-failure
#18
Jozine M Ter Maaten, Adriaan A Voors, Kevin Damman, Peter van der Meer, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Pim van der Harst, Hans L Hillege, Chim C Lang, Marco Metra, Gerjan Navis, Leong Ng, Wouter Ouwerkerk, Piotr Ponikowski, Nilesh J Samani, Dirk J van Veldhuisen, Faiez Zannad, Aeilko H Zwinderman, Martin H de Borst
BACKGROUND: Fibroblast growth factor (FGF) 23 is a hormone that increases urinary phosphate excretion and regulates renal sodium reabsorption and plasma volume. We studied the role of plasma FGF23 in therapy optimization and outcomes in patients with new-onset and worsening heart failure (HF). METHODS: We measured plasma C-terminal FGF23 levels at baseline in 2399 of the 2516 patients included in the BIOlogy Study to Tailored Treatment in Chronic HF (BIOSTAT-CHF) trial...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29305015/alternative-splicing-in-genetic-diseases-improved-diagnosis-and-novel-treatment-options
#19
Atze J Bergsma, Erik van der Wal, Mike Broeders, Ans T van der Ploeg, W W M Pim Pijnappel
Alternative splicing is an important mechanism to regulate gene expression and to expand the repertoire of gene products in order to accommodate an increase in complexity of multicellular organisms. It needs to be precisely regulated, which is achieved via RNA structure, splicing factors, transcriptional regulation, and chromatin. Changes in any of these factors can lead to disease. These may include the core spliceosome, splicing enhancer/repressor sequences and their interacting proteins, the speed of transcription by RNA polymerase II, and histone modifications...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29304166/how-japanese-companion-dog-and-cat-owners-degree-of-attachment-relates-to-the-attribution-of-emotions-to-their-animals
#20
Bingtao Su, Naoko Koda, Pim Martens
Recently, studies in the United States and European countries have shown that the degree of attachment is associated with the attribution of emotions to companion animals. These studies imply that investigating the degree of attachment to companion animals is a good way for researchers to explore animal emotions and then improve animal welfare. Although a promising area of study, in Japan, no empirical studies have examined the correlation between the degree of attachment and the attribution of emotions to companion animals...
2018: PloS One
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