keyword
MENU ▼
Read by QxMD icon Read
search

PIMS

keyword
https://www.readbyqxmd.com/read/28529088/pilot-test-of-a-home-based-program-to-prevent-perceived-insufficient-milk
#1
Natsuko K Wood, Elizabeth A Sanders, Frances M Lewis, Nancy F Woods, Susan T Blackburn
PROBLEM: Although the World Health Organization and American Academy of Pediatrics recommend exclusive breastfeeding for the first six months, only 22% of U.S. mothers do so. Mothers' perceived insufficient milk (PIM) is the primary reason for breastfeeding discontinuation globally. There are two changeable causes of PIM: (1) mothers' misinterpretation of their infant's behavior, and (2) mothers' lack of confidence in their ability to breastfeed. AIM: The purpose of this study was to evaluate the short-term effect of a home-based intervention designed to prevent and/or reduce PIM...
May 18, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28526882/prediction-of-cognitive-and-motor-outcome-of-preterm-infants-based-on-automatic-quantitative-descriptors-from-neonatal-mr-brain-images
#2
Pim Moeskops, Ivana Išgum, Kristin Keunen, Nathalie H P Claessens, Ingrid C van Haastert, Floris Groenendaal, Linda S de Vries, Max A Viergever, Manon J N L Benders
This study investigates the predictive ability of automatic quantitative brain MRI descriptors for the identification of infants with low cognitive and/or motor outcome at 2-3 years chronological age. MR brain images of 173 patients were acquired at 30 weeks postmenstrual age (PMA) (n = 86) and 40 weeks PMA (n = 153) between 2008 and 2013. Eight tissue volumes and measures of cortical morphology were automatically computed. A support vector machine classifier was employed to identify infants who exhibit low cognitive and/or motor outcome (<85) at 2-3 years chronological age as assessed by the Bayley scales...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28523101/design-and-synthesis-of-potent-and-selective-pim-kinase-inhibitors-by-targeting-unique-structure-of-atp-binding-pocket
#3
Hirofumi Nakano, Tsukasa Hasegawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano
In the development of kinase inhibitors, one of the major concerns is selectivity. An effective strategy to achieve high selectivity is to utilize structural differences among kinases to inform inhibitor design. Here, we set out to improve the PIM (proviral integration site for Moloney murine leukemia virus) kinase-inhibitory selectivity of our previously reported 7-azaindole derivative 2, which has promising ADMET properties, by targeting a unique bulge in the ATP-binding pocket. 6-Substituted 7-azaindoles, especially the 6-chlorinated derivatives, proved to be potent and selective PIM kinase inhibitors and appear to be promising lead compounds for future drug discovery...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28510303/cucurbit-8-uril-and-14-3-3-based-binary-bivalent-supramolecular-protein-assembly-platform-and-co-crystal-structure
#4
Pim de Vink, Jeroen Briels, Thomas Schrader, Lech Milroy, Luc Brunsveld, Christian Ottmann
Interactions between proteins frequently employ recognition sequences that engage in multivalent binding events. Dimeric 14-3-3 adapter proteins represent a prominent example, typically binding partner proteins in a phosphorylation-dependent mono- or bivalent manner. Here we describe the development of a cucurbit[8]uril (Q8)-based supramolecular system, which in conjunction with the 14-3-3 protein dimer acts as a binary and bivalent protein assembly platform. We fused the phenylalanine-glycine-glycine (FGG) tripeptide motif to the N-terminus of the 14-3-3-binding epitope of the estrogen receptor α (ERα), for selective binding to Q8...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28509727/lower-dementia-risk-with-different-classes-of-antihypertensive-medication-in-older-patients
#5
Tessa van Middelaar, Lonneke A van Vught, Eric P Moll van Charante, Lisa S M Eurelings, Suzanne A Ligthart, Jan W van Dalen, Bert Jan H van den Born, Edo Richard, Pim W A van Gool
OBJECTIVE: Use of antihypertensive medication (AHM) is potentially associated with a reduced risk of dementia. Both calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs) are suggested to have a more pronounced protective effect. We aimed to study the association between different classes of AHM and dementia in older people. METHODS: A subgroup of community-dwelling older people using AHM included in the 'Prevention of Dementia by Intensive Vascular Care' randomized controlled trial was studied...
May 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28507759/emerging-local-ablative-therapies-for-unresectable-perihilar-cholangiocarinoma-time-for-re-appraisal
#6
Pim B Olthof, Robert J Coelen, Michal Heger, Heinz-Josef Klümpen, Erik A Rauws, Thomas M van Gulik
No abstract text is available yet for this article.
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28507700/stepwise-observation-and-quantification-and-mixed-matrix-membrane-separation-of-co2-within-a-hydroxy-decorated-porous-host
#7
Christopher G Morris, Nicholas M Jacques, Harry G W Godfrey, Tamoghna Mitra, Detlev Fritsch, Zhenzhong Lu, Claire A Murray, Jonathan Potter, Tom M Cobb, Fajin Yuan, Chiu C Tang, Sihai Yang, Martin Schröder
The identification of preferred binding domains within a host structure provides important insights into the function of materials. State-of-the-art reports mostly focus on crystallographic studies of empty and single component guest-loaded host structures to determine the location of guests. However, measurements of material properties (e.g., adsorption and breakthrough of substrates) are usually performed for a wide range of pressure (guest coverage) and/or using multi-component gas mixtures. Here we report the development of a multifunctional gas dosing system for use in X-ray powder diffraction studies on Beamline I11 at Diamond Light Source...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28506569/-identifying-potentially-inappropriate-prescriptions-in-patients-over-65-years-old-using-original-beers-criteria-and-their-spanish-adaptation
#8
Josep Pastor Cano, Ana Aranda García, Juan José Gascón Cánovas, José Francisco Sánchez Ruiz, Víctor José Rausell Rausell, Mariana Tobaruela Soto
OBJECTIVE: To compare the detection of potentially inappropriate medication (PIM) using the original Beers criteria, a global reference for evaluating prescriptions in the elderly, and their Spanish version. DESIGN: Retrospective observational study LOCATION: A Primary Care area in the province of Murcia, Spain. PARTICIPANTS: A total of 7,856 subjects aged 65 and over, with at least one drug prescribed in a Primary Care Area of Spain during study period...
May 13, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28504859/anxiety-there-is-an-app-for-that-a-systematic-review-of-anxiety-apps
#9
REVIEW
Madalina Sucala, Pim Cuijpers, Frederick Muench, Roxana Cardoș, Radu Soflau, Anca Dobrean, Patriciu Achimas-Cadariu, Daniel David
BACKGROUND: Smartphones and mobile devices have become ubiquitous, and with the rapid advance of technology, the number of health applications (apps) that are available for consumers on these devices is constantly growing. In particular, there has been a recent proliferation of anxiety apps. However, there has been no review of the quality or content of these anxiety apps and little is known about their purpose, the features they contain, and their empirical support. The goal of this systematic review was to assess the commercially available anxiety apps...
May 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28497096/patient-complaints-emphasize-non-technical-aspects-of-care-at-a-tertiary-referral-hospital
#10
John D King, Pim A D van Dijk, Celeste L Overbeek, Michiel G J S Hageman, David Ring
BACKGROUND: Patient concerns represent opportunities for improvement in orthopaedic care. This study's objective is to identify the nature and prevalence of unsolicited patient complaints regarding orthopaedic care at a tertiary referral hospital. The primary null hypothesis that there are no demographic factors associated with complaint types was tested. Secondarily we determined if the overall complaint number and types differed by year. METHODS: Complaints to the hospital ombudsperson by orthopaedic patients between January 1997 and June 2013 were reviewed...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28496072/improvement-of-chromium-vi-extraction-from-acidic-solutions-using-a-poly-vinyl-chloride-based-polymer-inclusion-membrane-with-aliquat-336-as-the-carrier
#11
Shigehiro Kagaya, Tomonori Maeno, Kazuma Ito, Makoto Gemmei-Ide, Robert W Cattrall, Spas D Kolev
An important reason for the inefficient extraction of Cr(VI) from its acidic solutions into polymer inclusion membranes (PIMs), consisting of poly(vinyl chloride) as the base-polymer and Aliquat 336 as the carrier, was found to be associated with the leaching of Aliquat 336 from the PIMs into the solutions, where it subsequently reduced the anionic Cr(VI) species to cationic Cr(III) species. The PIM extraction efficiency for Cr(VI) was significantly improved by the addition of NaNO3 to the solutions, which suppressed the leaching of Aliquat 336 and the reduction of Cr(VI) to Cr(III)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28495388/recognizing-and-differentiating-uncommon-body-fluids-considerations-and-tools-for-a-proper-practical-approach
#12
REVIEW
Pim M W Janssens
Clinical laboratories are regularly requested to inspect uncommon body fluids obtained from patients because clinicians are uncertain as to the origin of the collected material. They may need this information for the actual diagnosis, to confirm a supposition, or for guiding treatment and invasive operations like draining and puncturing. Often there is also a need to know more precisely what is going on in the cavity that gave rise to the fluid, for instance a local infection or metastasis, or whether the cavity is connected to organs or fluid compartments nearby etcetera...
May 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28494306/membranes-based-on-polymer-miscibility-for-selective-transport-and-separation-of-metallic-ions
#13
Djamila Zioui, Omar Arous, Nabil Mameri, Hacène Kerdjoudj, M San Sebastian, J L Vilas, J Nunes-Pereira, Senentxu Lanceros-Méndez
Polymer inclusion membranes (PIM) used for selective transport and separation of metallic ions have emerged in recent times. Their expansion depends on the method of preparation and their suitable structure and physico-chemical characteristics. In this paper, a novel category of membranes for ions separation is reported. The membranes were synthesized by thermally induced phase separation using a mixture of polyvinylidene fluoride (PVDF) and cellulose triacetate (CTA) plasticized by tris(2-ethylhexyl) phosphate (TEHP) and with di-(2-ethylhexyl) phosphoric acid (D2EHPA) incorporated into the polymer as carrier to increase specific interactions between polymers...
April 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28492448/drivers-and-barriers-for-adopting-accreditation-at-local-health-departments-for-their-performance-improvement-effort
#14
Sandra S Liu, Beth Meyerson, Jerry King, Yuehwern Yih, Mina Ostovari
CONTEXT: A national system of voluntary public health accreditation for state, local, and tribal health departments (local health departments [LHDs]) is part of a movement that aims to improve public health performance with ultimate impact on population health outcomes. Indiana is a good setting for the study of LHD accreditation adoption because several LHDs reported de-adopting accreditation in a recent statewide survey and because 71% of Indiana counties serve populations of 50 000 or less...
May 10, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28489071/exchange-pathways-of-plastoquinone-and-plastoquinol-in-the-photosystem-ii-complex
#15
Floris J Van Eerden, Manuel N Melo, Pim W J M Frederix, Xavier Periole, Siewert J Marrink
Plastoquinone (PLQ) acts as an electron carrier between photosystem II (PSII) and the cytochrome b6f complex. To understand how PLQ enters and leaves PSII, here we show results of coarse grained molecular dynamics simulations of PSII embedded in the thylakoid membrane, covering a total simulation time of more than 0.5 ms. The long time scale allows the observation of many spontaneous entries of PLQ into PSII, and the unbinding of plastoquinol (PLQol) from the complex. In addition to the two known channels, we observe a third channel for PLQ/PLQol diffusion between the thylakoid membrane and the PLQ binding sites...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28487013/placental-pim-1-expression-is-increased-in-obesity-and-regulates-cytokine-and-toll-like-receptor-mediated-inflammation
#16
Stella Liong, Gillian Barker, Martha Lappas
INTRODUCTION: Obesity is a growing epidemic, and as a consequence the number of obese pregnancies has also increased. Pregnancy is characterised by maternal and placental inflammation which is intensified with maternal obesity. The proviral integration site for Moloney murine leukemic virus (Pim)-1 protein is a serine/threonine kinase involved in a wide range of inflammatory diseases. In relation to obesity, however, its role has not been elucidated in human placenta. The aims were to determine the placental expression of Pim-1 with pre-existing maternal obesity and its role in regulating placental inflammation associated with obesity...
May 2017: Placenta
https://www.readbyqxmd.com/read/28486815/incident-use-of-a-potentially-inappropriate-medication-and-hip-fracture-in-community-dwelling-older-persons-with-alzheimer-s-disease
#17
Virva Hyttinen, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Hannu Valtonen
BACKGROUND: Potentially inappropriate medications (PIMs) increase the risk of adverse drug reactions and events and have been associated with greater health care service use, such as an increased risk of hospitalization. OBJECTIVE: The aim of this study is to evaluate the association between PIM use and hip fractures in a nationwide cohort of community-dwelling persons ≥65 years old with Alzheimer's disease (AD). METHODS: The study, which is based on the Finnish nationwide MEDALZ cohort, included all persons diagnosed with AD between 2005 and 2011 (n = 70 718)...
May 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28483413/european-association-for-neuro-oncology-eano-guideline-on-the-diagnosis-and-treatment-of-adult-astrocytic-and-oligodendroglial-gliomas
#18
REVIEW
Michael Weller, Martin van den Bent, Jörg C Tonn, Roger Stupp, Matthias Preusser, Elizabeth Cohen-Jonathan-Moyal, Roger Henriksson, Emilie Le Rhun, Carmen Balana, Olivier Chinot, Martin Bendszus, Jaap C Reijneveld, Frederick Dhermain, Pim French, Christine Marosi, Colin Watts, Ingela Oberg, Geoffrey Pilkington, Brigitta G Baumert, Martin J B Taphoorn, Monika Hegi, Manfred Westphal, Guido Reifenberger, Riccardo Soffietti, Wolfgang Wick
The European Association for Neuro-Oncology guideline provides recommendations for the clinical care of adult patients with astrocytic and oligodendroglial gliomas, including glioblastomas. The guideline is based on the 2016 WHO classification of tumours of the central nervous system and on scientific developments since the 2014 guideline. The recommendations focus on pathological and radiological diagnostics, and the main treatment modalities of surgery, radiotherapy, and pharmacotherapy. In this guideline we have also integrated the results from contemporary clinical trials that have changed clinical practice...
May 5, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28483034/accuracy-of-national-key-performance-indicator-reporting-from-two-aboriginal-medical-services-potential-to-underestimate-the-performance-of-primary-health-care
#19
(no author information available yet)
Objective The aim of the present study was to assess the accuracy of extracting national key performance indicator (nKPI) data for the Online Community Health Reporting Environment for Health Services (OCHREStreams) program using the Pen Computer Systems (Leichhardt, NSW, Australia) Clinical Audit Tool (CAT) from Communicare (Telstra Health Communicare Systems, Perth, WA, Australia), a commonly used patient information management system (PIMS) in Aboriginal primary care.Methods Two Aboriginal Community-Controlled Health Services (ACCHSs) were recruited to the present study...
May 9, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28478703/a-bioreactor-to-identify-the-driving-mechanical-stimuli-of-tissue-growth-and-remodeling
#20
Mathieu A J van Kelle, Pim J A Oomen, Jurgen A Bulsink, Marloes W J T Janssen-van den Broek, Richard G P Lopata, Marcel Rutten, Sandra Loerakker, Carlijn Bouten
Tissue growth and remodeling are essential processes that should ensure long-term functionality of tissue engineered (TE) constructs. Even though it is widely recognized that these processes strongly depend on mechanical stimuli, the underlying mechanisms of mechanically-induced growth and remodeling are only partially understood. It is generally accepted that cells sense mechanical changes and respond by altering their surroundings, by means of extracellular matrix (ECM) growth and remodeling, in an attempt to return to a certain preferred mechanical homeostatic state...
May 6, 2017: Tissue Engineering. Part C, Methods
keyword
keyword
102940
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"