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https://www.readbyqxmd.com/read/29146648/economic-evaluation-of-an-e-mental-health-intervention-for-patients-with-retinal-exudative-diseases-who-receive-intraocular-anti-vegf-injections-e-pseye-protocol-for-a-randomised-controlled-trial
#1
Hilde P A van der Aa, Ger H M B van Rens, Frank D Verbraak, Machteld Bosscha, Marc A Koopmanschap, Hannie C Comijs, Pim Cuijpers, Ruth M A van Nispen
INTRODUCTION: Because of the great potential of vascular endothelial growth factor inhibitors (anti-VEGF) for retinal exudative diseases, an increased number of patients receives this treatment. However, during this treatment, patients are subjected to frequent invasive intravitreal injections, and the effects on reversing the process of vision loss are uncertain, which may have negative consequences for patients' mental health. One in three patients experience at least mild symptoms of depression/anxiety...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29142012/a-transcatheter-interatrial-shunt-device-for-the-treatment-of-heart-failure-with-preserved-ejection-fraction-reduce-lap-hf-i-a-phase-2-randomized-sham-controlled-trial
#2
Ted Feldman, Laura Mauri, Rami Kahwash, Sheldon Litwin, Mark J Ricciardi, Pim van der Harst, Martin Penicka, Peter S Fail, David M Kaye, Mark C Petrie, Anupam Basuray, Scott L Hummel, Rhondalyn Forde-McLean, Christopher D Nielsen, Scott Lilly, Joseph M Massaro, Daniel Burkhoff, Sanjiv J Shah
Background -In non-randomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), less symptoms, and greater quality of life and exercise capacity in patients with heart failure (HF) and mid-range or preserved ejection fraction (EF ≥ 40%). We conducted the first randomized, sham-controlled trial to evaluate the IASD in HF with EF ≥ 40%. Methods -REDUCE LAP-HF I was a phase 2, randomized, parallel-group, blinded multicenter trial in patients with New York Heart Association (NYHA) class III or ambulatory class IV HF, EF ≥ 40%, exercise PCWP ≥ 25 mmHg, and PCWP-right atrial pressure gradient ≥ 5 mmHg...
November 15, 2017: Circulation
https://www.readbyqxmd.com/read/29140915/the-actual-versus-idealized-self-exploring-responses-to-feedback-about-implicit-bias-in-health-professionals
#3
Javeed Sukhera, Alexandra Milne, Pim W Teunissen, Lorelei Lingard, Chris Watling
PURPOSE: Implicit bias can adversely affect health disparities. The implicit association test (IAT) is a prompt to stimulate reflection; however, feedback about bias may trigger emotions that reduce the effectiveness of feedback interventions. Exploring how individuals process feedback about implicit bias may inform bias recognition and management curricula. The authors sought to explore how health professionals perceive the influence of the experience of taking the IAT and receiving their results...
November 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29140460/a-meta-analysis-of-social-skills-training-and-related-interventions-for-psychosis
#4
David T Turner, Edel McGlanaghy, Pim Cuijpers, Mark van der Gaag, Eirini Karyotaki, Angus MacBeth
Objective: Evidence suggests that social skills training (SST) is an efficacious intervention for negative symptoms in psychosis, whereas evidence of efficacy in other psychosis symptom domains is limited. The current article reports a comprehensive meta-analytic review of the evidence for SST across relevant outcome measures, control comparisons, and follow-up assessments. The secondary aim of this study was to identify and investigate the efficacy of SST subtypes. Methods: A systematic literature search identified 27 randomized controlled trials including N = 1437 participants...
November 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29138901/-which-factors-are-associated-with-the-use-of-potentially-inadequate-medications-pim-in-the-elderly-results-from-the-german-health-interview-and-examination-survey-degs1
#5
Heinz G Endres, Petra Kaufmann-Kolle, Hildtraud Knopf, Petra A Thürmann
BACKGROUND: Recent studies demonstrate a relationship between the prescription of potentially inappropriate medications (PIM) for patients 65 years or older and an increased risk for adverse events, in particular hospitalisations. The RKI conducted DEGS1-Survey ("German health interview and examination survey for adults") provides a representative sample of the target population to identify determinants for PIM use. OBJECTIVE: The aim of this study was to determine characteristics of older persons in Germany, who currently use PIM, and if there are subpopulations among older persons with a particularly high PIM use...
November 14, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29136874/a-rapid-detection-method-for-policy-sensitive-amines-real-time-supervision
#6
Haixu Zhang, Jinian Shu, Bo Yang, Peng Zhang, Pengkun Ma
Many organic amines that comprise a benzene ring are policy-sensitive because of their toxicity and links to social harm. However, to date, detection of such compounds mainly relies on offline methods. This study proposes an online pptv (parts per trillion by volume) level of detection method for amines, using the recently-built vacuum ultraviolet photoionization mass spectrometer (VUV-PIMS) combined with a new doping technique. Thus, the dichloromethane doping-assisted photoionization mass spectra of aniline, benzylamine, phenethylamine, amphetamine, and their structural isomers were recorded...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132497/from-micro-to-macro-assessing-implementation-of-integrated-care-in-australia
#7
Lisa Angus, Pim P Valentijn
Many countries and health systems are pursuing integrated care as a means of achieving better outcomes. However, no standard approaches exist for comparing integration approaches across models or settings, and for evaluating whether the key components of integrated care are present in different initiatives. This study sheds light on how integrated care is being implemented in Australia, using a new tool to characterise and compare integration strategies at micro, meso and macro levels. In total, 114 staff from a purposive sample of 38 integrated care projects completed a survey based on the Rainbow Model of Integrated Care...
November 14, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29131444/native-t1-reference-values-for-nonischemic-cardiomyopathies-and-populations-with-increased-cardiovascular-risk-a-systematic-review-and-meta-analysis
#8
REVIEW
Maaike van den Boomen, Riemer H J A Slart, Enzo V Hulleman, Rudi A J O Dierckx, Birgitta K Velthuis, Pim van der Harst, David E Sosnovik, Ronald J H Borra, Niek H J Prakken
BACKGROUND: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. PURPOSE: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. STUDY TYPE: Systemic review and meta-analysis...
November 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29128999/impact-of-potentially-inappropriate-medications-and-polypharmacy-on-3-month-readmission-among-older-patients-discharged-from-acute-care-hospital-a-prospective-study
#9
Paolo Fabbietti, Giuseppina Di Stefano, Raffaella Moresi, Laura Cassetta, Mirko Di Rosa, Filippo Fimognari, Valentina Bambara, Giovanni Ruotolo, Alberto Castagna, Carmen Ruberto, Fabrizia Lattanzio, Andrea Corsonello
BACKGROUND: Polypharmacy and potentially inappropriate medications (PIMs) are known to affect several negative outcomes in older patients. However, studies comparatively assessing polypharmacy and PIMs in relation to readmission are distinctively lacking. AIMS: To compare the impact of polypharmacy and PIMs on 3-month readmission among older patients discharged from acute care hospital. METHODS: Our series consisted of 647 patients consecutively enrolled in a multicenter observational study...
November 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29128809/icariin-induces-apoptosis-in-acute-promyelocytic-leukemia-by-targeting-pim1
#10
Hong Zhang, Ping Li, Jing Li, Tongguo Song, Lin Wang, Enze Li, Jiao Wang, Luning Wang, Na Wei, Zhi Wang
BACKGROUND: Acute promyelocytic leukemia (APL) is one type of acute myeloid leukemia (AML) featured by abnormal, heavily granulated promyelocytes. This study aimed to investigate the antitumor activity of icariin in APL cells. METHODS: APL cell lines (HL-60 and NB4) were used to investigate the effect of icariin in vitro. Cell viability was determined by WST-8 proliferation assay, while cell apoptosis was assessed by flow cytometry. The mRNA and protein expression was determined by quantitative real-time polymerase chain reaction and Western blot, respectively...
June 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29126672/does-portal-vein-embolization-prior-to-liver-resection-influence-the-oncological-outcomes-a-propensity-score-matched-comparison
#11
Joost Huiskens, Pim B Olthof, Eric P van der Stok, Thomas Bais, Krijn P van Lienden, Adriaan Moelker, Jan Krumeich, Rudi M Roumen, Dirk J Grünhagen, Cornelis J A Punt, Martin van Amerongen, Johannes H W de Wilt, Cornelis Verhoef, Thomas M Van Gulik
INTRODUCTION: There is an ongoing controversy surrounding portal vein embolization (PVE) regarding the short-term safety of PVE and long-term oncological benefit. This study aims to compare survival outcomes of patients subjected to major liver resection for colorectal liver metastases (CRLM) with or without PVE. METHODS: All consecutive patients who underwent major liver resection for CRLM in four high volume liver centres between January 2000 and December 2015 were included...
September 20, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29124675/pim-2-cooperates-with-downstream-factor-xiap-to-inhibit-apoptosis-and-intensify-malignant-grade-in-prostate-cancer
#12
Ke Ren, Xin Gou, Mingzhao Xiao, Weiyang He, Jian Kang
To find the exact downstream effector of Pim-2 pathway in prostate cancer cells, and to determine the means by which it affects prostate cancer. XIAP, Pim-2 and p-eIF4B expressions were detected in PCA and BPH tissues. Then the Pim-2 and XIAP expressions were manipulated using transfection or RNAi in prostatic cells. Finally, Pim-2/eIF4B/XIAP levels were examined in PCA tissues with different clinicopathologic features. XIAP was significantly higher in PCA than in BPH tissues. When Pim-2 was transfected into noncancerous prostate epithelial cells RWPE-1, Pim-2, p-eIF4B and XIAP were all significantly increased and the apoptosis rate was significantly decreased...
November 9, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29118264/accumulation-of-5-oxoproline-in-myocardial-dysfunction-and-the-protective-effects-of-oplah
#13
Atze van der Pol, Andres Gil, Herman H W Silljé, Jasper Tromp, Ekaterina S Ovchinnikova, Inge Vreeswijk-Baudoin, Martijn Hoes, Ibrahim J Domian, Bart van de Sluis, Jan M van Deursen, Adriaan A Voors, Dirk J van Veldhuisen, Wiek H van Gilst, Eugene Berezikov, Pim van der Harst, Rudolf A de Boer, Rainer Bischoff, Peter van der Meer
In response to heart failure (HF), the heart reacts by repressing adult genes and expressing fetal genes, thereby returning to a more fetal-like gene profile. To identify genes involved in this process, we carried out transcriptional analysis on murine hearts at different stages of development and on hearts from adult mice with HF. Our screen identified Oplah, encoding for 5-oxoprolinase, a member of the γ-glutamyl cycle that functions by scavenging 5-oxoproline. OPLAH depletion occurred as a result of cardiac injury, leading to elevated 5-oxoproline and oxidative stress, whereas OPLAH overexpression improved cardiac function after ischemic injury...
November 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29116449/comparative-pulvinar-organization-across-different-primate-species
#14
Ricardo Gattass, Juliana G M Soares, Bruss Lima
In this chapter, we compare the pattern of pulvinar immunohistochemical staining for the calcium-binding proteins calbindin and parvalbumin and for the neurofilament protein SMI-32 in macaque, capuchin, and squirrel monkeys. This group of New and Old World primates shares five similar pulvinar subdivisions: PIP, PIM, PIC, PIL, and PILS. In the Old World macaque monkey, the inferior-lateral pulvinar can be subdivided into the P1 and P2 fields based on its connectivity with visual area V1. On the other hand, only the P1 field and no P2 was found in the New World capuchin monkey...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29115185/component-studies-of-psychological-treatments-of-adult-depression-a-systematic-review-and-meta-analysis
#15
Pim Cuijpers, Ioana A Cristea, Eirini Karyotaki, Mirjam Reijnders, Steven D Hollon
OBJECTIVES: A recent report from the US Institute of Medicine indicated that identifying core elements of psychosocial interventions is a key step in successfully bringing evidence-based psychosocial interventions into clinical practice. Component studies have the best design to examine these core elements. Earlier reviews resulted in heterogeneous sets of studies and probably missed many studies. METHODS: We conducted a comprehensive search of component studies on psychotherapies for adult depression and included 16 studies with 22 comparisons...
November 7, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29112992/risk-factors-for-dystonia-after-selective-dorsal-rhizotomy-in-nonwalking-children-and-adolescents-with-bilateral-spasticity
#16
Laura A van de Pol, Jeroen R Vermeulen, Charlotte van 't Westende, Petra E M van Schie, Eline A M Bolster, Pim W J R van Ouwerkerk, Rob L Strijers, Jules G Becher, Agnita Stadhouder, Pim de Graaf, Annemieke I Buizer
No abstract text is available yet for this article.
November 7, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/29111160/corrigendum-to-cd95-mediated-apoptosis-in-burkitt-s-lymphoma-b-cells-is-associated-with-pim-1-down-regulation-biochimica-et-biophysica-acta-1863-1-2017-239-252
#17
Sabine Matou-Nasri, Zaki Rabhan, Haya Albuayjan, Hamad Al-Eidi, Wesam Bin Yahya, Abdelkareem Al Abdulrahman, Nasser Almobadel, Mona Alsubeai, Saleh Al Ghamdi, Ahmed Alaskar, Mohammed AlBalwi, Mohsen Alzahrani, Ibrahim Alabdulkareem
No abstract text is available yet for this article.
October 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29111105/pim-activity-in-tumours-a-key-node-of-therapy-resistance
#18
REVIEW
Richard J Rebello, Alisée V Huglo, Luc Furic
The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.
October 22, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29110314/post-irradiation-morphoea-of-the-breast-a-case-report-and-review-of-the-literature
#19
Paula I Gonzalez-Ericsson, Monica V Estrada, Rami Al-Rohil, Melinda E Sanders
We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Clinically, PIM is misdiagnosed commonly as lymphoedema and cellulitis in the early inflammatory phase, and recurrent breast cancer, chronic radiodermatitis (CRD), radiation-induced fibrosis (RIF), post-irradiation pseudosclerodermatous panniculitis (PIPP), atypical vascular lesions (AVL) or angiosarcoma (AS) in the late burnout phase...
August 14, 2017: Histopathology
https://www.readbyqxmd.com/read/29108877/pim-kinases-from-survival-factors-to-regulators-of-cell-motility
#20
REVIEW
Niina M Santio, Päivi J Koskinen
PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which are tightly regulated in normal tissues, but upregulated in many types of human malignancies, including both hematological and solid cancers. Since high PIM expression levels have been connected to cancer progression and poor patient survival, PIM kinases have become attractive targets for drug development. Many downstream targets have also been identified, through which PIM kinases promote cell survival, proliferation and metabolism...
November 3, 2017: International Journal of Biochemistry & Cell Biology
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