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https://www.readbyqxmd.com/read/28333348/promoter-characterization-and-expression-of-the-blakpc-2-gene-in-escherichia-coli-pseudomonas-aeruginosa-and-acinetobacter-baumannii
#1
Delphine Girlich, Rémy A Bonnin, Agnes Jousset, Thierry Naas
Objectives: KPC-producing pathogens exhibit variable carbapenem susceptibility levels, which is probably the result of the genetic environment of the bla KPC genes. Here we determined the transcriptional start sites (TSSs) and the expression of the bla KPC-2 gene in various genetic contexts and in different hosts ( Escherichia coli , Pseudomonas aeruginosa and Acinetobacter baumannii ). Methods: The bla KPC-2 genes along with the upstream sequences derived from Tn 4401b (structure A), Tn 4401b interrupted by Tn 3 /IS 26 (structure B) and Tn 4401b interrupted by Tn 5563 (structure C) were cloned in two E...
March 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333279/inhibition-of-pim1-kinase-attenuates-inflammation-induced-pro-labour-mediators-in-human-fetal-membranes-in-vitro
#2
Ratana Lim, Gillian Barker, Martha Lappas
STUDY QUESTION: Does proviral integration site for Moloney murine leukemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery? SUMMARY ANSWER: PIM1 kinase plays a critical role in fetal membranes in regulating pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY: Infection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes...
March 9, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28326807/perception-of-not-having-enough-milk-and-actual-milk-production-of-first-time-breastfeeding-mothers-is-there-a-difference
#3
Roseline Galipeau, Louise Dumas, Mario Lepage
OBJECTIVE: This study aimed to determine the relationship between perceived insufficient milk supply (PIMS) and actual insufficient milk supply (AIMS) and the relative contributions of physiological and psychosocial variables on both PIMS and AIMS of first-time breastfeeding mothers. PARTICIPANTS AND METHODS: Data were collected among 123 breastfeeding mothers at a Canadian, French-speaking maternal care hospital. Birth events, breastfeeding practices, infant and maternal capacities, and PIMS and AIMS were collected at 48 hours after birth, postnatal weeks 2 and 6...
March 22, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28322655/mothers-with-perceived-insufficient-milk
#4
Natsuko K Wood, Elizabeth A Sanders
Perceived insufficient milk (PIM) is the primary reason for breastfeeding discontinuation globally. This study evaluated the short-term impact of mother-infant interactions through home interventions designed to overcome PIM as a result of the infant's behavior, delivered to 14 dyads of breastfeeding mothers and their full-term singleton infants. A single group, three-occasion prepost design was used. Mother-infant interactions were measured by the Nursing Child Assessment Feeding Scale (NCAFS) at 6, 13, and 27 days postpartum...
January 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28315116/evaluating-the-prevalence-of-potentially-inappropriate-prescribing-in-older-adults-in-intermediate-care-facilities-a-cross-sectional-observational-study
#5
Anna Millar, Carmel Hughes, Cristín Ryan
Background Potentially inappropriate prescribing (PIP) [encompassing potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs)], is prevalent amongst older adults in primary and secondary care. However, PIP prevalence in intermediate care (IC) is unknown. Objective To determine the prevalence of PIMs/PPOs and associated patient factors. Setting Three IC facilities in Northern Ireland. Method The Screening Tool of Older People's Prescriptions and the Screening Tool to Alert doctors to Right Treatment were used to identify PIP over 8 weeks...
March 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28302143/altered-aortic-3d-hemodynamics-and-geometry-in-pediatric-marfan-syndrome-patients
#6
Roel L F van der Palen, Alex J Barker, Emilie Bollache, Julio Garcia, Michael J Rose, Pim van Ooij, Luciana T Young, Arno A W Roest, Michael Markl, Joshua D Robinson, Cynthia K Rigsby
BACKGROUND: Blood flow dynamics make it possible to better understand the development of aortopathy and cardiovascular events in patients with Marfan syndrome (MFS). Aortic 3D blood flow characteristics were investigated in relation to aortic geometry in children and adolescents with MFS. METHODS: Twenty-five MFS patients (age 15.6 ± 4.0 years; 11 females) and 21 healthy controls (age 16.0 ± 2.6 years; 12 females) underwent magnetic resonance angiography and 4D flow CMR for assessment of thoracic aortic size and 3D blood flow velocities...
March 17, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28300345/benzimidazole-pyridoimidazole-cored-organic-sensitizers-for-high-performance-dye-sensitized-solar-cells
#7
Sumit Chaurasia, Chun Ting Li, Mulu Berhe Desta, Jen Shyang Ni, Jiann T Lin
A new series of benzimidazole (BIm) based dyes (SC32 and SC33) and pyridoimidazole (PIm) based dyes (SC35 and SC36) were synthesized as the sensitizers for dye-sensitized solar cells. The N-substituent and C-substituent at the BIm and PIm cores was found to be the dominating factor in deciding the electronic properties of the dyes and their DSSCs performance. The efficiency of BIm-based dyes (SC35 and SC36) was found higher than the BIm-based dyes (SC32 and SC33) due to better light harvesting. The C-substituent in SC36, 4-hexylloxybenzene, is beneficial to dark current suppression, and hence SC36 achieves the best efficiency of 7...
March 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28296897/ice-cover-is-the-principal-driver-of-ecological-change-in-high-arctic-lakes-and-ponds
#8
Katherine Griffiths, Neal Michelutti, Madeline Sugar, Marianne S V Douglas, John P Smol
Recent climate change has been especially pronounced in the High Arctic, however, the responses of aquatic biota, such as diatoms, can be modified by site-specific environmental characteristics. To assess if climate-mediated ice cover changes affect the diatom response to climate, we used paleolimnological techniques to examine shifts in diatom assemblages from ten High Arctic lakes and ponds from Ellesmere Island and nearby Pim Island (Nunavut, Canada). The sites were divided a priori into four groups ("warm", "cool", "cold", and "oasis") based on local elevation and microclimatic differences that result in differing lengths of the ice-free season, as well as about three decades of personal observations...
2017: PloS One
https://www.readbyqxmd.com/read/28295758/internet-interventions-for-adult-illicit-substance-users-a-meta-analysis
#9
REVIEW
Nikolaos Boumparis, Eirini Karyotaki, Michael P Schaub, Pim Cuijpers, Heleen Riper
BACKGROUND AND AIMS: Research has shown that internet interventions can be effective for dependent users of various substances. However, less is known about the effects of these interventions on users of opioids, cocaine, and amphetamines than for other substances. We aimed to investigate the effectiveness of internet interventions in decreasing the usage of these types of substances. METHODS: We conducted a systematic literature search in the databases of PubMed, PsycINFO, Embase, and the Cochrane Library to identify randomized controlled trials examining the effectiveness of internet interventions compared with control conditions in reducing the use of opioids, cocaine, and amphetamines...
March 10, 2017: Addiction
https://www.readbyqxmd.com/read/28293951/case-study-on-screening-emerging-pollutants-in-urine-and-nails
#10
Andreia Alves, Georgios Giovanoulis, Ulrika Lena Nilsson, Claudio Erratico, Luisa Lucattini, Line Småstuen Haug, Griet Jacobs, Cynthia A de Wit, Pim E G Leonards, Adrian Covaci, Jorgen Magnér, Stefan Voorspoels
New plasticizers and flame retardants (FRs) have been introduced as replacements for banned or restricted chemicals, but very little is known about their metabolism and presence in humans. A recent study determined the metabolites formed in vitro for four alternative plasticizers (acetyltributyl citrate (ATBC), bis(2-propylheptyl) phthalate (DPHP), bis(2-ethylhexyl) terephthalate (DEHTP), bis(2-ethylhexyl) adipate (DEHA)) and one FR (i.e. 2,2-bis(chloromethyl)-propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate (V6))...
March 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28286171/epigallocatechin-3-gallate-increases-autophagy-signaling-in-resting-and-unloaded-plantaris-muscles-but-selectively-suppresses-autophagy-protein-abundance-in-reloaded-muscles-of-aged-rats
#11
Hideyuki Takahashi, Yutaka Suzuki, Junaith S Mohamed, Takafumi Gotoh, Suzette L Pereira, Stephen E Alway
We have previously found that Epigallocatechin-3-gallate (EGCg), an abundant catechin in green tea, reduced apoptotic signaling and improved muscle recovery in response to reloading after hindlimb suspension (HS). In this study, we investigated if EGCg altered autophagy signaling in skeletal muscle of old rats in response to HS or reloading after HS. Fischer 344×Brown Norway inbred rats (age 34months) were given 1ml/day of purified EGCg (50mg/kg body weight), or the same sample volume of the vehicle by gavage...
March 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28284416/using-the-beers-criteria-to-identify-potentially-inappropriate-medication-use-by-older-adult-dental-patients
#12
Daniel D Skaar, Heidi O'Connor
BACKGROUND: An aging population indicates that increasing numbers of older adults will seek oral health care and have multiple chronic conditions treated with a number of medications. The authors examined the Medicare Current Beneficiary Survey administrative data set to characterize potentially inappropriate medication (PIM) use by older adults visiting the dentist and related adverse experiences that may affect oral health care. METHODS: The authors used the 2015 Beers criteria to identify PIMs for older adults...
March 8, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28279621/high-mortality-after-alpps-for-perihilar-cholangiocarcinoma-case-control-analysis-including-the-first-series-from-the-international-alpps-registry
#13
Pim B Olthof, Robert J S Coelen, Jimme K Wiggers, Bas Groot Koerkamp, Massimo Malago, Roberto Hernandez-Alejandro, Stefan A Topp, Marco Vivarelli, Luca A Aldrighetti, Ricardo Robles Campos, Karl J Oldhafer, William R Jarnagin, Thomas M van Gulik
INTRODUCTION: Resection of perihilar cholangiocarcinoma (PHC) entails high-risk surgery with postoperative mortality reported up to 18%, even in specialized centers. The aim of this study was to compare outcomes of PHC patients who underwent associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) to patients who underwent resection without ALPPS. METHODS: All patients who underwent ALPPS for PHC were identified from the international ALPPS registry and matched controls were selected from a standard resection cohort from two centers based on future remnant liver size...
March 6, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28277572/inter-and-intramolecular-aldol-reactions-promiscuously-catalyzed-by-a-proline-based-tautomerase
#14
Mehran Rahimi, Edzard M Geertsema, Yufeng Miao, Jan-Ytzen van der Meer, Thea van den Bosch, Pim de Haan, Ellen Zandvoort, Gerrit J Poelarends
The enzyme 4-oxalocrotonate tautomerase (4-OT), which in nature catalyzes a tautomerization step as part of a catabolic pathway for aromatic hydrocarbons, was found to promiscuously catalyze different types of aldol reactions. These include the self-condensation of propanal, the cross-coupling of propanal and benzaldehyde, the cross-coupling of propanal and pyruvate, and the intramolecular cyclizations of hexanedial and heptanedial. Mutation of the catalytic amino-terminal proline (P1A) greatly reduces 4-OT's aldolase activities, whereas mutation of another active site residue (F50A) strongly enhances 4-OT's aldolase activities, indicating that aldolization is an active site process...
March 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28273128/prevalence-risk-factors-and-health-outcomes-associated-with-polypharmacy-among-urban-community-dwelling-older-adults-in-multi-ethnic-malaysia
#15
Li Min Lim, Megan McStea, Wen Wei Chung, Nuruljannah Nor Azmi, Siti Azdiah Abdul Aziz, Syireen Alwi, Adeeba Kamarulzaman, Shahrul Bahyah Kamaruzzaman, Siew Siang Chua, Reena Rajasuriar
BACKGROUND: Polypharmacy has been associated with increased morbidity and mortality in the older population. OBJECTIVES: The aim of this study was to determine the prevalence, risk factors and health outcomes associated with polypharmacy in a cohort of urban community-dwelling older adults receiving chronic medications in Malaysia. METHODS: This was a baseline study in the Malaysian Elders Longitudinal Research cohort. The inclusion criteria were individuals aged ≥55years and taking at least one medication chronically (≥3 months)...
2017: PloS One
https://www.readbyqxmd.com/read/28270272/implementation-and-assessment-of-an-ambulatory-prescribing-guidance-tool-to-improve-patient-safety-in-the-geriatric-population
#16
Daniel J Ruhland, Jessica M Bellone, Erin Wilkes
OBJECTIVE: The purpose of this study was to assess the effects of a clinical decision support (CDS) tool aimed at decreasing the prescribing of glyburide, a potentially inappropriate medication (PIM), in patients 65 years of age and older. DESIGN: Quasi-experimental, pre-post intervention study. SETTING: Ambulatory care clinics of an academic medical center. INTERVENTION: The tool appeared to providers when entering new prescriptions or refills for glyburide...
March 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28266062/k-t-accelerated-aortic-4d-flow-mri-in-under-two-minutes-feasibility-and-impact-of-resolution-k-space-sampling-patterns-and-respiratory-navigator-gating-on-hemodynamic-measurements
#17
Emilie Bollache, Alex J Barker, Ryan Scott Dolan, James C Carr, Pim van Ooij, Rouzbeh Ahmadian, Alex Powell, Jeremy D Collins, Julia Geiger, Michael Markl
PURPOSE: To assess the performance of highly accelerated free-breathing aortic four-dimensional (4D) flow MRI acquired in under 2 minutes compared to conventional respiratory gated 4D flow. METHODS: Eight k-t accelerated nongated 4D flow MRI (parallel MRI with extended and averaged generalized autocalibrating partially parallel acquisition kernels [PEAK GRAPPA], R = 5, TRes = 67.2 ms) using four ky -kz Cartesian sampling patterns (linear, center-out, out-center-out, random) and two spatial resolutions (SRes1 = 3...
March 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28258500/a-prevalence-study-of-potentially-inappropriate-medications-use-in-hospitalized-pakistani-elderly
#18
Faizan Mazhar, Shahzad Akram, Saima Mahmood Malhi, Nafis Haider
BACKGROUND: Inappropriate prescribing in elderly patients is a widespread health problem. It is associated with increased drug-related problems and health expenditure. AIMS: To determine the prevalence and types of potentially inappropriate medications (PIM) prescribed to elderly patients with polypharmacy and the factors associated with their use in these patients. METHODS: A cross-sectional study conducted among 228 elderly hospitalized patients with polypharmacy...
March 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28252392/convnet-based-localization-of-anatomical-structures-in-3d-medical-images
#19
Bob de Vos, Jelmer Wolterink, Pim de Jong, Tim Leiner, Max Viergever, Ivana Isgum
Localization of anatomical structures is a prerequisite for many tasks in medical image analysis. We propose a method for automatic localization of one or more anatomical structures in 3D medical images through detection of their presence in 2D image slices using a convolutional neural network (ConvNet). A single ConvNet is trained to detect presence of the anatomical structure of interest in axial, coronal, and sagittal slices extracted from a 3D image. To allow the ConvNet to analyze slices of different sizes, spatial pyramid pooling is applied...
February 23, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28249086/efficacy-of-psychotherapies-for-borderline-personality-disorder-a-systematic-review-and-meta-analysis
#20
Ioana A Cristea, Claudio Gentili, Carmen D Cotet, Daniela Palomba, Corrado Barbui, Pim Cuijpers
Importance: Borderline personality disorder (BPD) is a debilitating condition, but several psychotherapies are considered effective. Objective: To conduct an updated systematic review and meta-analysis of randomized clinical trials to assess the efficacy of psychotherapies for BPD populations. Data Sources: Search terms were combined for borderline personality and randomized trials in PubMed, PsycINFO, EMBASE, and the Cochrane Central Register of Controlled Trials (from database inception to November 2015), as well as the reference lists of earlier meta-analyses...
March 1, 2017: JAMA Psychiatry
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