keyword
https://read.qxmd.com/read/38491997/the-effects-of-a-large-scale-home-visiting-programme-for-child-development-on-use-of-health-services-in-brazil
#1
JOURNAL ARTICLE
Eduardo Viegas da Silva, Fernando Pires Hartwig, Aisha Yousafzai, Andréa Dâmaso Bertoldi, Joseph Murray
Partnership between early childhood development interventions and primary health care services can help catalyse health care uptake by socially vulnerable families. This study aimed to assess the real-life effects of a large-scale home visiting programme [Primeira Infância Melhor (PIM)] in Brazil on the use of preventive (prenatal visits, well child visits, dentist visits and vaccination) and recovery (emergency room visits and hospitalization) health services. A quasi-experiment nested in a population-based birth cohort study was conducted...
February 29, 2024: Health Policy and Planning
https://read.qxmd.com/read/38490212/multimodal-stimulation-screens-reveal-unique-and-shared-genes-limiting-t%C3%A2-cell-fitness
#2
JOURNAL ARTICLE
Chun-Pu Lin, Pierre L Levy, Astrid Alflen, Georgi Apriamashvili, Maarten A Ligtenberg, David W Vredevoogd, Onno B Bleijerveld, Ferhat Alkan, Yuval Malka, Liesbeth Hoekman, Ettai Markovits, Austin George, Joleen J H Traets, Oscar Krijgsman, Alex van Vliet, Joanna Poźniak, Carlos Ariel Pulido-Vicuña, Beaunelle de Bruijn, Susan E van Hal-van Veen, Julia Boshuizen, Pim W van der Helm, Judit Díaz-Gómez, Hamdy Warda, Leonie M Behrens, Paula Mardesic, Bilal Dehni, Nils L Visser, Jean-Christophe Marine, Gal Markel, William J Faller, Maarten Altelaar, Reuven Agami, Michal J Besser, Daniel S Peeper
Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been systematically studied whether there are regulators that uniquely or broadly contribute to T cell fitness. We perform genome-scale CRISPR-Cas9 knockout screens in primary CD8 T cells to uncover genes negatively impacting fitness upon three modes of stimulation: (1) intense, triggering activation-induced cell death (AICD); (2) acute, triggering expansion; (3) chronic, causing dysfunction. Besides established regulators, we uncover genes controlling T cell fitness either specifically or commonly upon differential stimulation...
March 13, 2024: Cancer Cell
https://read.qxmd.com/read/38487950/evaluation-of-the-efficacy-of-inter-dental-brush-and-dental-floss-for-peri-implant-mucositis-a-crossover-randomized-clinical-trial
#3
JOURNAL ARTICLE
Lorenzo Bevilacqua, Maria Giulia Lorenzon, Marianna Bjedov, Fulvia Costantinides, Daniele Angerame, Michele Maglione
OBJECTIVES: To evaluate the most effective method for mechanical inter-dental plaque removal between inter-dental brushes (IDB) and dental floss (DF), in addition to toothbrushing in patients affected by peri-implant mucositis (PIM); to identify possible factors related to the patient or to the single implant-supported element that could influence plaque accumulation and inflammation of peri-implant tissues. METHODS: Forty patients with PIM were recruited. They were randomly assigned to two different groups depending on inter-dental device used (IDB or DF)...
March 15, 2024: International Journal of Dental Hygiene
https://read.qxmd.com/read/38485819/kinase-pim1-governs-ferroptosis-to-reduce-retinal-microvascular-endothelial-cell-dysfunction-triggered-by-high-glucose
#4
JOURNAL ARTICLE
Hong-Bin Xie, Jun-Hong Guo, Ming-Min Yang, Jian-Tao Wang
Previous studies have implicated targeting Pim-1 proto-oncogene, serine/threonine kinase (PIM1) as a preventive measure against high glucose-induced cellular stress and apoptosis. This study aimed to reveal the potential role and regulatory mechanism of PIM1 in diabetic retinopathy. Human retinal microvascular endothelial cells (hRMECs) underwent high glucose induction, and fluctuations in PIM1 levels were assessed. By overexpressing PIM1, its effects on the levels of inflammatory factors, oxidative stress indicators, migration and tube formation abilities, tight junction protein expression levels, and ferroptosis in hRMECs were identified...
March 14, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38485672/photothermal-conversion-porous-organic-polymers-design-synthesis-and-applications
#5
REVIEW
Yu Shi, Yuzhu Wang, Nan Meng, Yaozu Liao
Solar energy is a primary form of renewable energy, and photothermal conversion is a direct conversion process with tunable conversion efficiency. Among various kinds of photothermal conversion materials, porous organic polymers (POP) are widely investigated owing to their controllable molecular design, tailored porous structures, good absorption of solar light, and low thermal conductivity. A variety of POP, such as conjugated microporous polymers (CMP), covalent organic frameworks (COF), hyper-crosslinked porous polymers (HCP), polymers of intrinsic microporosity (PIM), porous ionic polymers (PIP), are developed and applied in photothermal conversion applications of seawater desalination, latent energy storage, and biomedical fields...
March 14, 2024: Small Methods
https://read.qxmd.com/read/38485277/strong-correlation-between-suv-max-on-psma-pet-ct-and-numeric-drop-in-%C3%AE-probe-signal-for-intraoperative-identification-of-prostate-cancer-lesions
#6
JOURNAL ARTICLE
Anne-Claire Berrens, Malou A Sorbi, Maarten L Donswijk, Hilda A de Barros, Samaneh Azargoshasb, Matthias N van Oosterom, Daphne D D Rietbergen, Elise M Bekers, Henk G van der Poel, Fijs W B van Leeuwen, Pim J van Leeuwen
Prostate-specific membrane antigen (PSMA) PET is used to select patients with recurrent prostate cancer for metastasis-directed therapy. A surgical approach can be achieved through radioguided surgery (RGS), using a Drop-In γ-probe that traces lesions that accumulate the radioactive signal. With the aim of guiding patient selection for salvage surgery, we studied the correlation between the SUVmax of lesions on preoperative PSMA PET/CT and their intraoperative counts/s measured using the Drop-In γ-probe...
March 14, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38484302/external-quality-assessment-on-molecular-tumor-profiling-with-circulating-tumor-dna-based-methodologies-routinely-used-in-clinical-pathology-within-the-coin-consortium
#7
JOURNAL ARTICLE
Paul van der Leest, Pim Rozendal, John Hinrichs, Carel J M van Noesel, Karen Zwaenepoel, Birgit Deiman, Cornelis J J Huijsmans, Ronald van Eijk, Ernst Jan M Speel, Rick J van Haastert, Marjolijn J L Ligtenberg, Ron H N van Schaik, Maurice P H M Jansen, Hendrikus J Dubbink, Wendy W de Leng, Mathie P G Leers, Menno Tamminga, Daan van den Broek, Léon C van Kempen, Ed Schuuring
BACKGROUND: Identification of tumor-derived variants in circulating tumor DNA (ctDNA) has potential as a sensitive and reliable surrogate for tumor tissue-based routine diagnostic testing. However, variations in pre(analytical) procedures affect the efficiency of ctDNA recovery. Here, an external quality assessment (EQA) was performed to determine the performance of ctDNA mutation detection work flows that are used in current diagnostic settings across laboratories within the Dutch COIN consortium (ctDNA on the road to implementation in The Netherlands)...
March 14, 2024: Clinical Chemistry
https://read.qxmd.com/read/38482818/imaging-findings-in-acute-traumatic-brain-injury-a-ninds-common-data-element-based-pictorial-review-and-analysis-of-over-4-000-admission-brain-ct-scans-from-the-center-tbi-study
#8
JOURNAL ARTICLE
Thijs Vande Vyvere, Dana Pisica, Guido Wilms, Lene Claes, Pieter Van Dyck, Annemiek Snoeckx, Luc van den Hauwe, Pim Pullens, Jan Verheyden, Max Wintermark, Sven Dekeyzer, Christine L Mac Donald, Andrew Maas, Paul Parizel
In 2010, the National Institute of Neurological Disorders and Stroke (NINDS) created a set of common data elements (CDEs) to help standardize the assessment and reporting of imaging findings in traumatic brain injury (TBI). However, as opposed to other standardized radiology reporting systems, a visual overview, and data to support the proposed standardized lexicon are lacking. We used over 4000 admission computerized tomography (CT) scans of patients with TBI from the CENTER-TBI study to develop an extensive pictorial overview of the NINDS TBI CDEs, with visual examples and background information on individual pathoanatomical lesion types, up to the level of supplemental and emerging information (e...
March 14, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38481828/polypharmacy-of-older-surgical-patients-with-extremity-fractures
#9
JOURNAL ARTICLE
Takumi Taniguchi, Risa Inagaki, Takehiro Michikawa, Soya Kawabata, Masahiro Yoshida, Yusuke Kawano, Mitsuhiro Morita, Kazue Hayakawa, Mitsunaga Iwata, Shigeki Yamada, Nobuyuki Fujita
INTRODUCTION: Fractures are often caused by falls in older people. Among various causes of falls, polypharmacy is known to be a risk of falls. Furthermore, potentially inappropriate medicines (PIMs), which interact with polypharmacy, include the drugs involved in falls. Here, we primarily aimed to investigate the prescribed drugs in older surgical patients with extremity fractures to determine the frequency of polypharmacy and identify PIMs. The second aim was to clarify the characterization of prescribed drugs of older patients with hip fracture...
2024: Geriatric Orthopaedic Surgery & Rehabilitation
https://read.qxmd.com/read/38477841/experimental-demonstration-of-real-time-cardiac-physiology-based-radiotherapy-gating-for-improved-cardiac-radioablation-on-an-mr-linac
#10
JOURNAL ARTICLE
Osman Akdag, Pim T S Borman, Stefano Mandija, Peter L Woodhead, Prescilla Uijtewaal, Bas W Raaymakers, Martin F Fast
BACKGROUND: Cardiac radioablation is a noninvasive stereotactic body radiation therapy (SBRT) technique to treat patients with refractory ventricular tachycardia (VT) by delivering a single high-dose fraction to the VT isthmus. Cardiorespiratory motion induces position uncertainties resulting in decreased dose conformality. Electocardiograms (ECG) are typically used during cardiac MRI (CMR) to acquire images in a predefined cardiac phase, thus mitigating cardiac motion during image acquisition...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38473565/design-of-sustainable-aluminium-based-feedstocks-for-composite-extrusion-modelling-cem
#11
JOURNAL ARTICLE
José L Aguilar-García, Eduardo Tabares Lorenzo, Antonia Jimenez-Morales, Elisa M Ruíz-Navas
Additive manufacturing (AM) has become one of the most promising manufacturing techniques in recent years due to the geometric design freedom that this technology offers. The main objective of this study is to explore Composite Extrusion Modelling (CEM) with aluminium as an alternative processing route for aluminium alloys. This process allows for working with pellets that are deposited directly, layer by layer. The aim of the technique is to obtain aluminium alloy samples for industrial applications with high precision, without defects, and which are processed in an environmentally friendly manner...
February 27, 2024: Materials
https://read.qxmd.com/read/38472674/higher-postoperative-mortality-and-inferior-survival-after-right-sided-liver-resection-for-perihilar-cholangiocarcinoma-left-sided-resection-is-preferred-when-possible
#12
JOURNAL ARTICLE
Pim B Olthof, Joris I Erdmann, Ruslan Alikhanov, Ramón Charco, Alfredo Guglielmi, Jeroen Hagendoorn, Abdul Hakeem, Frederik J H Hoogwater, William R Jarnagin, Geert Kazemier, Hauke Lang, Shishir K Maithel, Massimo Malago, Hassan Z Malik, Silvio Nadalin, Ulf Neumann, Steven W M Olde Damink, Johann Pratschke, Francesca Ratti, Matteo Ravaioli, Keith J Roberts, Erik Schadde, Andreas A Schnitzbauer, Ernesto Sparrelid, Baki Topal, Roberto I Troisi, Bas Groot Koerkamp
BACKGROUND: A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality and long-term survival of right- versus left-sided liver resections for pCCA. METHODS: Patients who underwent major liver resection for pCCA at 25 Western centers were stratified according to the type of hepatectomy-left, extended left, right, and extended right...
March 12, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38469832/who-benefits-from-indirect-prevention-and-treatment-of-depression-using-an-online-intervention-for-insomnia-results-from-an-individual-participant-data-meta-analysis
#13
JOURNAL ARTICLE
Janika Thielecke, Paula Kuper, Dirk Lehr, Lea Schuurmans, Mathias Harrer, David D Ebert, Pim Cuijpers, Dörte Behrendt, Hanna Brückner, Hanne Horvath, Heleen Riper, Claudia Buntrock
BACKGROUND: Major depressive disorder (MDD) is highly prevalent and burdensome for individuals and society. While there are psychological interventions able to prevent and treat MDD, uptake remains low. To overcome structural and attitudinal barriers, an indirect approach of using online insomnia interventions seems promising because insomnia is less stigmatized, predicts MDD onset, is often comorbid and can outlast MDD treatment. This individual-participant-data meta-analysis evaluated the potential of the online insomnia intervention GET...
March 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38469728/evolution-of-european-prostate-cancer-screening-protocols-and-summary-of-ongoing-trials
#14
REVIEW
Meike J van Harten, Monique J Roobol, Pim J van Leeuwen, Peter-Paul M Willemse, Roderick C N van den Bergh
Population-based organised repeated screening for prostate cancer has been found to reduce disease-specific mortality, but with substantial overdiagnosis leading to overtreatment. Although only very few countries have implemented a screening programme on a national level, individual prostate-specific antigen (PSA) testing is common. This opportunistic testing may have little favourable impact, while stressing the side-effects. The classic early detection protocols as were state-of-the-art in the 1990s applied a PSA and digital rectal examination threshold for sextant systematic prostate biopsy, with a fixed interval for re-testing, and limited indication for expectant management...
March 12, 2024: BJU International
https://read.qxmd.com/read/38467064/thermal-scanning-probe-and-laser-lithography-for-patterning-nanowire-based-quantum-devices
#15
JOURNAL ARTICLE
Lior Shani, Jana Chaaban, Alec Nilson, Eliott Clerc, Gavin Menning, Colin Riggert, Pim Lueb, Marco Rossi, Ghada Badawy, Erik P A M Bakkers, Vlad S Pribiag
Semiconductor nanowire (NW) quantum devices offer a promising path for the pursuit and investigation of topologically-protected quantum states, and superconducting and spin-based qubits that can be controlled using electric fields. Theoretical investigations into the impact of disorder on the attainment of dependable topological states in semiconducting nanowires with large spin orbit coupling and g-factor highlight the critical need for improvements in both growth processes and nanofabrication techniques. In this work, we used a hybrid lithography tool for both the high-resolution thermal scanning probe lithography and high-throughput direct laser writing of quantum devices based on thin InSb nanowires with contact spacing of 200 nm...
March 11, 2024: Nanotechnology
https://read.qxmd.com/read/38465509/high-level-of-c3-is-associated-with-th2-immune-response-and-liver-fibrosis-in-patients-with-schistosomiasis
#16
JOURNAL ARTICLE
Xianmo Wang, Quan Gong, Hao Nie, Jiancheng Tu, Wen Fan, Xiaoping Tan
Long-term infection of schistosomiasis will seriously affect the liver health of patients. The serum of 334 chronic Schistosoma japonicum patients and 149 healthy volunteers was collected. Compared with heathy people, the level of C4 (complement 4) was increased, and the level of C3 (complement 3) was in an obvious skewed distribution. ELISA was performed to detect the serum cytokines, the results showed that the levels of IFN-γ (interferon-γ), IL (interleukin)-2 and TNF-α (tumour necrosis factor-α) were reduced, while the levels of Th2 cytokines (IL-4, IL-6 and IL-10) were increased...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38455473/lessons-learned-spanning-17%C3%A2-years-of-experience-with-three-consecutive-nationwide-competency-based-medical-education-training-plans
#17
JOURNAL ARTICLE
Merel H de Heer, Erik W Driessen, Pim W Teunissen, Fedde Scheele
INTRODUCTION: Curricula for postgraduate medical education have transformed since the introduction of competency based medical education (CBME). Postgraduate training plans offer broader training with different competencies and an outcome-based approach, in addition to the medical technical aspects of training. However, CBME also has its challenges. Over the past years, critical views have been shared on the potential drawbacks of CBME, such as assessment burden and conflicts with practicality in the workplace...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38453405/deprescribing-in-older-patients-with-advanced-cancer-referred-to-palliative-care
#18
JOURNAL ARTICLE
Jorge Fernández-Fradejas, Hilario Martínez-Barros, Lourdes Rexach-Cano, Ana María Álvarez-Díaz, Eva Delgado-Silveira
OBJECTIVES: This study aimed to explore the prevalence of potentially inappropriate medications (PIMs) in a cohort of older adults with advanced cancer referred to palliative care. Secondary objectives were to describe the categories of identified PIMs and assess risk factors associated with their presence in this population. METHODS: This retrospective, observational study evaluated patients with advanced cancer admitted to a tertiary university hospital in Madrid, Spain and referred to palliative care between 1 January 2020 and 30 June 2020...
March 7, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38448738/aso-author-reflections-surgical-strategy-for-perihilar-cholangiocarcinoma
#19
JOURNAL ARTICLE
Pim B Olthof, Bas Groot Koerkamp
No abstract text is available yet for this article.
March 6, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38444665/the-relationship-of-fat-and-muscle-measurements-with-emphysema-and-bronchial-wall-thickening-in-smokers
#20
JOURNAL ARTICLE
Stijn A O Bunk, Jetty Ipema, Grigory Sidorenkov, Edwin Bennink, Rozemarijn Vliegenthart, Pim A de Jong, Esther Pompe, Jean-Paul Charbonnier, Bart H D Luijk, Joachim Aerts, Harry J M Groen, Firdaus A A Mohamed Hoesein
INTRODUCTION: Differences in body composition in patients with COPD may have important prognostic value and may provide opportunities for patient-specific management. We investigated the relation of thoracic fat and muscle with computed tomography (CT)-measured emphysema and bronchial wall thickening. METHODS: Low-dose baseline chest CT scans from 1031 male lung cancer screening participants from one site were quantified for emphysema, bronchial wall thickening, subcutaneous fat, visceral fat and skeletal muscle...
March 2024: ERJ Open Research
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