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dobutamine and shock in children

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https://www.readbyqxmd.com/read/27284371/antitumor-activity-of-dobutamine-on-human-osteosarcoma-cells
#1
Jun Yin, Qirong Dong, Minqian Zheng, Xiaozu Xu, Guoyou Zou, Guolin Ma, Kefeng Li
Dobutamine has been widely used for the treatment of heart failure and cardiogenic shock since the 1970s. Osteosarcoma is the most commonly observed malignant bone tumor in children. Currently, there are no effective drugs for the treatment of osteosarcoma. In the present study, the potential anticancer activity of dobutamine on human osteosarcoma cells was examined. Human osteosarcoma MG-63 cells were treated with dobutamine at various concentrations and for various incubation times. The inhibition of cell growth by dobutamine was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
June 2016: Oncology Letters
https://www.readbyqxmd.com/read/25208120/implementing-accm-critical-care-guidelines-for-septic-shock-management-in-a-cuban-pediatric-intensive-care-unit
#2
José M Cartaya, Luis E Rovira, Yamilet Segredo, Idalys Alvarez, Yoandra Acevedo, Ariel Moya
INTRODUCTION Sepsis is the most common direct cause of death worldwide and septic shock the syndrome's most serious complication. In 2002, the pediatric intensive care unit of the José Luis Miranda Pediatric University Hospital in Santa Clara (Villa Clara Province), Cuba, began implementing the recently published guidelines of the American College of Critical Care Medicine (ACCM) for management of pediatric and neonatal septic shock, observing a drop in case fatality from 34.6% to 19% between the years 2003 and 2007...
July 2014: MEDICC Review
https://www.readbyqxmd.com/read/24583504/early-goal-directed-therapy-in-pediatric-septic-shock-comparison-of-outcomes-with-and-without-intermittent-superior-venacaval-oxygen-saturation-monitoring-a-prospective-cohort-study
#3
COMPARATIVE STUDY
Jhuma Sankar, M Jeeva Sankar, C P Suresh, Nandkishore K Dubey, Archana Singh
OBJECTIVE: To evaluate the effect of intermittent central venous oxygen saturation monitoring (ScvO(2)) on critical outcomes in children with septic shock, as continuous monitoring may not be feasible in most resource-restricted settings. DESIGN: Prospective cohort study. SETTING: PICU of a tertiary care teaching hospital. PATIENTS: Consecutive children younger than 17 years with fluid refractory septic shock admitted to our ICU from November 2010 to October 2012 were included...
May 2014: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/24316266/cardiac-involvement-and-its-complications-about-three-cases-of-severe-scorpion-envenomation
#4
B Aboumaâd, A Tiger, A Khattabi, R Soulaymani, M Lahssaini, S M Benhassain, N Iba
For several decades, Morocco is confronted to medico-social problem of scorpion stings and envenomations. In 2009, epidemiological data established by the Poison Control Center recorded 29,816 stung patients, with an incidence of 1.1‰ and a fatality rate of 0.18%. The neurotoxins from scorpion venom are potent activators of the autonomic nervous system resulting a physiopathological disorder of vital systems. The most serious clinical manifestations are neurotoxic effects, pulmonary edema and cardiovascular distress...
February 2014: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/24133330/bedside-echocardiography-is-useful-in-assessing-children-with-fluid-and-inotrope-resistant-septic-shock
#5
Suchitra Ranjit, Niranjan Kissoon
OBJECTIVE: To report changes in the cardiovascular management of fluid and inotropic resistant septic shock in children based on echocardiography. DESIGN: Retrospective case series. SETTING: Tertiary care Pediatric Intensive Care Unit (PICU), Chennai. PATIENTS: Twenty-two patients with unresolved septic shock after 60 ml/kg fluid plus inotropic agents in the first hour. INTERVENTIONS: Bedside echocardiography (echo) within 6 h of admission to the PICU...
July 2013: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/23685637/milrinone-therapy-for-enterovirus-71-induced-pulmonary-edema-and-or-neurogenic-shock-in-children-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Chia-Yu Chi, Truong Huu Khanh, Le Phan Kim Thoa, Fan-Chen Tseng, Shih-Min Wang, Le Quoc Thinh, Chia-Chun Lin, Han-Chieh Wu, Jen-Ren Wang, Nguyen Thanh Hung, Tang Chi Thuong, Chung-Ming Chang, Ih-Jen Su, Ching-Chuan Liu
OBJECTIVE: Enterovirus 71-induced brainstem encephalitis with pulmonary edema and/or neurogenic shock (stage 3B) is associated with rapid mortality in children. In a small pilot study, we found that milrinone reduced early mortality compared with historical controls. This prospective, randomized control trial was designed to provide more definitive evidence of the ability of milrinone to reduce the 1-week mortality of stage 3B enterovirus 71 infections. DESIGN: Prospective, unicenter, open-label, randomized, controlled study...
July 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/23361625/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#7
R P Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23354787/paediatric-community-acquired-septic-shock-results-from-the-repem-network-study
#8
MULTICENTER STUDY
P Van de Voorde, B Emerson, B Gomez, J Willems, D Yildizdas, I Iglowstein, E Kerkhof, N Mullen, C R Pinto, T Detaille, N Qureshi, J Naud, J De Dooy, R Van Lancker, A Dupont, N Boelsma, M Mor, D Walker, M Sabbe, S Hachimi-Idrissi, L Da Dalt, H Waisman, D Biarent, I Maconochie, H Moll, J Benito
UNLABELLED: INTRODUCTION AND PURPOSE OF THE STUDY: With this study we aimed to describe a "true world" picture of severe paediatric 'community-acquired' septic shock and establish the feasibility of a future prospective trial on early goal-directed therapy in children. During a 6-month to 1-year retrospective screening period in 16 emergency departments (ED) in 12 different countries, all children with severe sepsis and signs of decreased perfusion were included. RESULTS: A 270,461 paediatric ED consultations were screened, and 176 cases were identified...
May 2013: European Journal of Pediatrics
https://www.readbyqxmd.com/read/23353941/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#9
R Phillip Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven A Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/22568565/noradrenaline-use-for-septic-shock-in-children-doses-routes-of-administration-and-complications
#10
M E Lampin, J Rousseaux, A Botte, A Sadik, R Cremer, F Leclerc
AIM: To report our 10 year experience with noradrenaline use in children with septic shock focusing on doses, routes of administration and complications. METHODS: Retrospective single-centre review of children with septic shock who received noradrenaline between 2000 and 2010. RESULTS: We identified 144 children with septic shock treated with noradrenaline, in 22% as the first-line drug. The median volume resuscitation before vasoactive agent administration was 50 mL/kg interquartile range [IQR: 30-70]...
September 2012: Acta Paediatrica
https://www.readbyqxmd.com/read/21541646/management-of-septic-shock
#11
Rakesh Lodha, Tejo Pratap Oleti, S K Kabra
Septic shock is an important cause of mortality in children with sepsis. The incidence of septic shock is 2-4% of admissions in western pediatric intensive care units and 40%-67% for Indian PICUs. Early goal-directed resuscitation that includes aggressive fluid resuscitation of up to 60 mL/kg as boluses of 20 mL/kg by IV push, to achieve desired heart rates and blood pressure, has emerged as mainstay of treatment in the initial stage. Crystalloids are the preferred fluids, while colloids may be used in some situations...
June 2011: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/18843251/serum-level-of-cardiac-troponin-i-in-pediatric-patients-with-sepsis-or-septic-shock
#12
Norma Suely Oliveira, Valmin Ramos Silva, Jane Sant' Ana Castelo, Jorge Elias-Neto, Fausto Edmundo Lima Pereira, Werther Brunow Carvalho
OBJECTIVES: To evaluate serum level of contractile protein troponin I (cTnI) within the 24 hrs of sepsis and septic shock diagnosis in children and to correlate with the outcome (discharge from hospital or death). DESIGN: Prospective, observational study. SETTING: Pediatric Intensive Care Unit, at Hospital Infantil Nossa Senhora da Glória, Vitória, ES, Brazil. PATIENTS: Two hundred eighteen consecutive admissions of septic patients...
July 2008: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/18842146/necrotizing-fasciitis-with-toxic-shock-syndrome-in-a-child-a-case-report-and-review-of-literature
#13
Kotb Abass, Hekma Saad, Alaa A Abd-Elsayed
INTRODUCTION: Necrotizing fasciitis was described as early as the fifth century BC. It showed an increased incidence worldwide in the past several years. CASE PRESENTATION: An 8-year-old Arabian boy was referred for admission as a case of cellulitis of the left thigh. Ten days prior to admission he had a cat scratch to his left thigh and the parents did not seek medical advice at that time. The child was again examined by orthopedic surgeon and a diagnosis of cellulites was made at that time...
2008: Cases Journal
https://www.readbyqxmd.com/read/18158437/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2008
#14
R Phillip Dellinger, Mitchell M Levy, Jean M Carlet, Julian Bion, Margaret M Parker, Roman Jaeschke, Konrad Reinhart, Derek C Angus, Christian Brun-Buisson, Richard Beale, Thierry Calandra, Jean-Francois Dhainaut, Herwig Gerlach, Maurene Harvey, John J Marini, John Marshall, Marco Ranieri, Graham Ramsay, Jonathan Sevransky, B Taylor Thompson, Sean Townsend, Jeffrey S Vender, Janice L Zimmerman, Jean-Louis Vincent
OBJECTIVE: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004. DESIGN: Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted independently of any industry funding...
January 2008: Critical Care Medicine
https://www.readbyqxmd.com/read/18092150/terlipressin-as-a-rescue-therapy-for-catecholamine-resistant-septic-shock-in-children
#15
RANDOMIZED CONTROLLED TRIAL
Dincer Yildizdas, Hacer Yapicioglu, Umit Celik, Yasar Sertdemir, Emre Alhan
OBJECTIVE: To evaluate the effect of terlipressin on oxygenation, PaO2/FIO2, heart rate, mean arterial pressure, and mortality in children with septic shock refractory to high doses of dopamine/dobutamine and adrenaline. DESIGN AND SETTING: A randomized, nonblind study in the pediatric intensive care unit of a university hospital. PATIENTS AND MEASUREMENTS: We studied 58 children with septic shock and refractory hypotension despite fluid loading and high doses of catecholamines, randomly enrolled to terlipressin (TP, n=30) or control (n=28)...
March 2008: Intensive Care Medicine
https://www.readbyqxmd.com/read/18058085/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2008
#16
R Phillip Dellinger, Mitchell M Levy, Jean M Carlet, Julian Bion, Margaret M Parker, Roman Jaeschke, Konrad Reinhart, Derek C Angus, Christian Brun-Buisson, Richard Beale, Thierry Calandra, Jean-Francois Dhainaut, Herwig Gerlach, Maurene Harvey, John J Marini, John Marshall, Marco Ranieri, Graham Ramsay, Jonathan Sevransky, B Taylor Thompson, Sean Townsend, Jeffrey S Vender, Janice L Zimmerman, Jean-Louis Vincent
OBJECTIVE: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004. DESIGN: Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted independently of any industry funding...
January 2008: Intensive Care Medicine
https://www.readbyqxmd.com/read/17945008/improved-survival-of-children-with-sepsis-and-purpura-effects-of-age-gender-and-era
#17
Martine Maat, Corinne M P Buysse, Marieke Emonts, Lodewijk Spanjaard, Koen F M Joosten, Ronald de Groot, Jan A Hazelzet
BACKGROUND: To gain insight into factors that might affect results of future case-control studies, we performed an analysis of children with sepsis and purpura admitted to the paediatric intensive care unit (PICU) of Erasmus MC-Sophia Children's Hospital (Rotterdam, The Netherlands). METHODS: Between 1988 and 2006, all 287 children consecutively admitted with sepsis and purpura were included in various sepsis studies. Data regarding age, gender, ethnicity, serogroup of Neisseria meningitidis, severity, therapy, and survival were collected prospectively...
2007: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/17530137/pharmacologic-support-of-infants-and-children-in-septic-shock
#18
REVIEW
José Irazuzta, Kevin J Sullivan, Pedro Celiny R Garcia, Jefferson Pedro Piva
OBJECTIVES: Septic shock (SS) is a frequent cause for admission to the pediatric intensive care unit, requiring prompt recognition and intervention to improve outcome. Our aim is to review the relevant literature related to the diagnosis and management of SS and present a sequential management for its treatment. SOURCES: Non-systematic review of medical literature using the MEDLINE database. Articles were selected according to their relevance to the objective and according to the authors' opinions...
May 2007: Jornal de Pediatria
https://www.readbyqxmd.com/read/17521855/-is-there-still-a-place-for-dopamine-in-the-paediatric-critical-care-setting
#19
REVIEW
F Leclerc, A Sadik
Dopamine is mostly used in patients with cardiogenic or septic shock, but its place in critical care medicine is often questioned. Dopamine, of which pharmacology in children is variable, is prescribed for its inotropic effect, associated with an increase in cardiac output and at a lesser degree blood pressure. Beneficial effects (need for renal replacement therapy and mortality) of low dose in patients at risk of, or with acute renal failure are not demonstrated. Dopamine has numerous potential deleterious effects on local circulations (pulmonary, cerebral, coronary and cutaneous), respiratory function, gastroduodenal motility, endocrine function (further depression of the hypothalamic-pituitary axis induced by stress) and immunity (partially due to decreased production of prolactin)...
June 2007: Annales Françaises D'anesthèsie et de Rèanimation
https://www.readbyqxmd.com/read/16997682/nonketotic-hyperglycemic-coma-in-toddlers-after-unintentional-methadone-ingestion
#20
Sinan Tiras, Vincent Haas, Laurent Chevret, Marion Decobert, Anne Buisine, Denis Devictor, Philippe Durand, Pierre Tissières
Methadone overdoses are increasing in parallel with the increased frequency of opiate substitution therapy in adults. Although unintentional methadone intoxication in children is rare, it is becoming more frequently recognized. We report 3 cases of unintentional methadone overdose in toddlers who initially displayed central nervous system depression associated with severe nonketotic hyperglycemia and discuss the possible pathophysiologic mechanisms of an underrecognized symptom of opiate intoxication in young children...
October 2006: Annals of Emergency Medicine
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