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Michio Tokuyama, Tomotaka Mabuchi
A 43-year-old Japanese man who had suffered psoriasis vulgaris for eight years visited our hospital. His comorbidities were dyslipidemia, hyperuricemia, and obesity. He received phototherapy for six months, which did not result in improvement. Following treatment with brodalumab, his skin symptoms improved. However, seven months after brodalumab treatment, he received two doses of the mRNA-1273 COVID-19 vaccine, with a one-month interval between doses. One month following the second vaccination, his skin symptoms were exacerbated...
December 20, 2023: Tokai Journal of Experimental and Clinical Medicine
#22
JOURNAL ARTICLE
Vahide Lajevardi, Zahra Sadat Seyed Hosseini, Sama Heidari
BACKGROUND: Vitiligo is an acquired skin disease with a worldwide prevalence of 0.5%-2% and a tendency to involve both genders. Although the exact pathologic mechanism is unknown, there is some evidence for the role of autoimmunity in this disease. Based on this theory, various immunosuppressive agents, such as topical or systemic corticosteroids and phototherapy (including narrowband ultraviolet B), are used. Methotrexate is another immunosuppressant that has recently become popular as a single treatment for vitiligo; however, the synergistic effect and its superiority over other treatments are two crucial factors that are still obscure...
October 20, 2023: Photodermatology, Photoimmunology & Photomedicine
#23
REVIEW
Khadeejeh Al-Smadi, Masood Ali, Seyed Ebrahim Alavi, Xuping Jin, Mohammad Imran, Vania R Leite-Silva, Yousuf Mohammed
Vitamin D is one significant prohormone substance in human organ systems. It is a steroidal hormone produced in the skin upon exposure to UVB rays. This paper presents a systematic review of the utilization of topical vitamin D, specifically cholecalciferol, calcipotriol, and tacalcitol, in the treatment of vitiligo. It considers the role of vitamin D in stimulating the synthesis of melanin and melanogenesis, which can help with the process of repigmentation. The inclusion of calcipotriol or tacalcitol in Narrowband Ultraviolet Phototherapy (NB-UVB) has shown the potential to enhance therapeutic outcomes for vitiligo...
September 30, 2023: Cells
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JOURNAL ARTICLE
Yingyuan Yu, Jing Zhou, Dawei Huang, Xiaoyuan Zhong, Luyang Kong, Yangfeng Ding, Xinling Bi, Hui Deng, Jianhua Chen, Jun Gu, Jiajing Lu, Yuling Shi
BACKGROUND: Psoriasis patients are more likely to have mental disorders. The relationship between the reduction of involvement area and severity of lesions and the associated improvement in anxiety and depression in psoriasis patients, remains inadequately researched. METHODS: 200 psoriasis patients were enrolled in this prospective study, and received 12-week narrowband ultraviolet B (NB-UVB) therapy. The Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), and Physician Global Assessment (PGA) scores were obtained as the objective assessments of disease, each reflecting distinct aspects of the disease...
October 10, 2023: Journal of Affective Disorders
#25
Suphagan Boonpethkaew, Jitlada Meephansan, Sasin Charoensuksira, Onjira Jumlongpim, Pattarin Tangtanatakul, Jongkonnee Wongpiyabovorn, Mayumi Komine, Akimichi Morita
No abstract text is available yet for this article.
September 22, 2023: Scientific Reports
#26
JOURNAL ARTICLE
Julien Seneschal, Reinhart Speeckaert, Alain Taïeb, Albert Wolkerstorfer, Thierry Passeron, Amit G Pandya, Henry W Lim, Khaled Ezzedine, Youwen Zhou, Flora Xiang, Steven Thng, Atsushi Tanemura, Tamio Suzuki, David Rosmarin, Michelle Rodrigues, Noufal Raboobee, Georg Pliszewski, Davinder Parsad, Naoki Oiso, Paul Monteiro, Jean Marie Meurant, Nicolle Maquignon, Harvey Lui, Caroline Le Poole, Giovanni Leone, Ai-Young Lee, Eric Lan, Ichiro Katayama, Richard Huggins, Sang Ho Oh, John E Harris, Iltefat H Hamzavi, Somesh Gupta, Pearl Grimes, Boon Kee Goh, Deepti Ghia, Samia Esmat, Viktoria Eleftheriadou, Markus Böhm, Laila Benzekri, Marcel Bekkenk, Jung Min Bae, Augustin Alomar, Marwa Abdallah, Mauro Picardo, Nanja van Geel
BACKGROUND: The treatment of vitiligo can be challenging. Up-to-date agreed consensus recommendations on the use of topical and systemic therapies to facilitate the clinical management of vitiligo are currently lacking. OBJECTIVES: To develop internationally agreed-upon expert-based recommendations for the treatment of vitiligo. METHODS: In this consensus statement, a consortium of 42 international vitiligo experts and four patient representatives participated in different online and live meetings to develop a consensus management strategy for vitiligo...
November 2023: Journal of the European Academy of Dermatology and Venereology: JEADV
#27
COMPARATIVE STUDY
Diala Alshiyab, Firas Al-Qarqaz, Saleh Ba-Shammakh, Abdulqudos Al-Fakih, Aya Altawalbeh, Safa' Alsheyab, Danyah Sarakbi, Jihan Muhaidat
Purpose: Vitiligo is an idiopathic depigmenting skin disorder. The study compares the efficacy of topical tacrolimus 0.1% with calcipotriol/betamethasone dipropionate in vitiligo patients receiving NB-UVB treatment. Materials and methods: Forty-one adult patients with generalized type vitiligo were recruited. Patients were assigned to phototherapy and then classified into either group one (20 patients), receiving calcipotriol/betamethasone dipropionate cream (D group), or group two (21 patients), receiving tacrolimus 0...
December 2023: Journal of Dermatological Treatment
#28
JOURNAL ARTICLE
Yomna Mazid El-Hamd Neinaa, Myada Abd Elmohsen Mahmoud, Gamal Mohamed El Maghraby, Zeinab Abd Elsamd Ibrahim
In the recent decades, prostaglandins were recommended as a new therapeutic modality of stable vitiligo with promising efficacy. Therefore, we designed the current work to compare the significance of two different subtypes of prostaglandins [prostaglandin E2 (PGE2) versus prostaglandin F2 alpha (PGF2α)], assisted with NB-UVB phototherapy, in treatment of stable vitiligo. This study was conducted on 30 patients with stable non-segmental vitiligo. Three approximately similar vitiliginous areas were chosen in each patient and assigned into 3 groups...
August 18, 2023: Archives of Dermatological Research
#29
JOURNAL ARTICLE
Giovanni Damiani, Alessia Pacifico, Egeria Scoditti, Sara di Gregorio, Massimo Del Fabbro, Claudia Cozzolino, Alessandra Buja, Santo R Mercuri, Vittoria G Bianchi, Ayman Grada, Sergio Garbarino, Christopher G Bunick
INTRODUCTION: Minimal erythema dose (MED) remains a parameter of paramount importance to orient narrow-band (NB)-UVB phototherapy in psoriatic (PsO) patients. Recently, circadian rhythm and diet were recognized as potential MED modulators, but their mutual interaction remains understudied. Thus, we aimed to evaluate the potential diet modulation of MED circadian oscillations. METHODS: In the first phase, a cohort study was performed comparing potential MED oscillations (morning, afternoon, and evening) among omnivorous psoriatic patients before and after a phototherapy cycle and omnivorous healthy controls...
October 2023: Dermatology and Therapy
#30
JOURNAL ARTICLE
Randa Youssef, Nourhan Emad, Rania M Mogawer
INTRODUCTION: There are diverse assessment tools for vitiligo, with no standardized approach that helps unify treatment outcome measures. Thus, comparing different treatment modalities and developing evidence-based recommendations for vitiligo management has been quite challenging. OBJECTIVES: We compared the most commonly used tools assessing both vitiligo activity and extent, namely, Vitiligo Disease Activity Score (VIDA) and Vitiligo Area and Severity Index (VASI) score to their newly developed counterparts, namely, Vitiligo Extent Score Plus (VES plus) and Vitiligo Signs of Activity score (VSAS), to provide insights that would help set recommendations for a unified outcome assessment protocol for vitiligo patients...
July 1, 2023: Dermatology Practical & Conceptual
#31
JOURNAL ARTICLE
Jenna Yousif, Alice B Gottlieb, Roudha Al-Dehneem
Pemphigus foliaceus is an autoimmune blistering disease of the skin that is not frequently associated with mucous membrane involvement. It is characterized by immunoglobulin G (IgG) antibodies against desmoglein-1, a component of epidermal intercellular adhesion, in the granular layer of the epidermis. Pemphigus foliaceus consists of scattered, arcuate, crusted erythematous lesions often in a seborrheic distribution that may progress to diffuse skin involvement and exfoliative erythroderma. Several cases in the literature discuss pemphigus foliaceus arising in patients with pre-existing psoriatic disease following treatment with narrow-band ultraviolet-B (NB-UVB) therapy...
August 1, 2023: Journal of Drugs in Dermatology: JDD
#32
JOURNAL ARTICLE
Lamia H Elgarhy, Rania A Eltatawy, Omnia Rizk, Mayada Ismail
BACKGROUND/PURPOSE: Psoriasis is a multifactorial disease. It is a combination of genetic, immunological, and environmental factors. Vitamin D receptor (VDR) is a nuclear receptor that regulates epidermal cell growth through the inhibition of proliferation and induction of keratinocytes terminal differentiation. Aim of the study was to investigate the effect of Narrow-band UVB (NB-UVB) therapy on VDR expression in the skin of psoriasis patients. MATERIALS AND METHODS: Forty patients with different severities of psoriasis were assessed using the psoriasis area and severity index (PASI) score...
2023: Journal of Cutaneous and Aesthetic Surgery
#33
JOURNAL ARTICLE
Suvesh Singh, Sujay Khandpur, Vinod K Sharma, Neetu Bhari, Ravindra M Pandey
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the standard therapy for vitiligo. OBJECTIVE: The objective of this study is to compare the safety and clinical efficacy of a handheld NB-UVB comb device with the standard whole-body NB-UVB therapy in localized stable vitiligo. MATERIALS AND METHODS: Thirty-one vitiligo patients were allocated to either daily therapy with a home-based handheld comb device (group A, n = 17) or thrice-weekly hospital-based whole-body NB-UVB therapy (group B, n = 14) for 4 months, based on their preference...
2023: Indian Dermatology Online Journal
#34
JOURNAL ARTICLE
Andrea Elmelid, Maria Siekkeri Vandikas, Martin Gillstedt, Amra Osmancevic, Mikael Alsterholm
Vitamin D plays an important role in skin inflammation in psoriasis. The beneficial effects of ultraviolet light B (UVB) phototherapy in psoriasis are partly attributed to UVB-induced increase of vitamin D levels. In clinical practice, total 25-hydroxy vitamin D (25(OH)D) levels are measured to assess sufficiency, but it might be more accurate to measure free 25(OH)D levels. The aim of this study was to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and to investigate if free 25(OH)D correlates stronger to disease severity than total 25(OH)D...
June 21, 2023: Biomolecules
#35
Ziqing Li, Jie Lu, Jiaxin Ou, Jingjie Yu, Chuanjian Lu
Background: Psoriasis vulgaris (PV) is a longstanding, inflammatory, immune-responsive skin condition. Chinese herbal medicine injections (CHMIs) have been utilized for treating PV in Asian countries. This study aims to conduct a thorough systematic review and meta-analysis to comprehensively appraise the efficacy of CHMIs in treating PV. Methods: Seven databases were searched for randomized controlled trials that evaluated the effect of CHMIs in treating PV, ranging from 2004 to June 2022. The meta-analysis was undertaken based on outcome measures, treatment options, and treatment durations using Review Manager 5...
2023: Frontiers in Pharmacology
#36
JOURNAL ARTICLE
Xihui Shan, Xiao Ying, Yanjie Liang, Yi Zhang, Xulong Lv, Dongxun Chen, Shihai Miao, Lixin Ning
Narrowband ultraviolet-B (NB-UVB) luminescent materials are characterized by high photon energy, narrow spectral width, and visible-blind emission, thus holding great promise for photochemistry and photomedicine. However, most NB-UVB phosphors developed so far are photoluminescent, where continuous external excitation is needed. Herein, we realize NB-UVB persistent luminescence (PersL) in an indoor-lighting environment by exploiting the interaction between self-trapped/defect-trapped excitons and Gd3+ emitters in ScPO4 ...
July 18, 2023: Inorganic Chemistry
#37
JOURNAL ARTICLE
Yiwen Mao, Huiyao Ge, Weiwei Chen, YiRui Wang, Hao Liu, Zhuo Li, Yuanming Bai, Daiyue Wang, Yafen Yu, Qi Zhen, Bao Li, Liangdan Sun
The vascular endothelial growth factor (VEGF) signal transduction pathway has been shown to be a potential target for the treatment of psoriasis. Ras guanyl-releasing protein 1 (RasGRP1), a downstream target gene of VEGF, regulates the development, homeostasis, and differentiation of T cells, but the contribution of RasGRP1 to psoriasis is limited. In this manuscript, we aimed to investigate the role of RasGRP1 in psoriasis. The RNA-Seq transcriptome sequencing data from the mouse model of psoriasis treated with IMQ (imiquimod) were analyzed...
July 8, 2023: International Immunopharmacology
#38
JOURNAL ARTICLE
Aislyn Oulee, Grace S Ahn, Sogol S Javadi, Jashin J Wu
Phototherapy has gained popularity in the recent decades for the treatment of various immune-mediated dermatological conditions since it is more-cost effective and less toxic compared to systemic therapies. This systematic review aims to inform dermatology providers of the risks and benefits of phototherapy, especially in patients at risk for malignancies. Ionizing energy from phototherapy results in DNA photolesions, namely of cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). Without adequate repair, these mutations increase the risk for carcinogenesis...
June 2023: Journal of Clinical and Aesthetic Dermatology
#39
JOURNAL ARTICLE
Esra Agaoglu, Hilal Kaya Erdogan, Ersoy Acer, Zeynep Nurhan Saracoglu, Muzaffer Bilgin
INTRODUCTION: Pityriasis lichenoides (PL) is a papulosquamous disease affecting both children and adults, for which narrowband-UVB (NB-UVB) phototherapy is regarded as a commonly used treatment option. The aim of this study was to investigate the efficacy of NB-UVB phototherapy in the management of PL and to compare response rates in pediatric and adult age groups. MATERIALS AND METHODS: This observational, retrospective study included 20 PL patients (12 pityriasis lichenoides chronica; PLC, 8 pityriasis lichenoides et varioliformis acuta; PLEVA) who failed to respond to other treatment modalities...
June 20, 2023: Photodermatology, Photoimmunology & Photomedicine
#40
JOURNAL ARTICLE
Mariateresa Rossi, Caterina Damiani, Mariachiara Arisi, Cesare Tomasi, Francesco Tonon, Marina Venturini, Piergiacomo Calzavara-Pinton
Narrow-band (NB) UVB and UVA1 have been successfully used for the treatment of atopic dermatitis (AD) since the 1980s, but the clinical indications for their use "at the age of biologics" remain to be assessed. From 2013 to 2017, 145 patients underwent a first treatment cycle with phototherapy. They achieved a median final EASI score of 9.90 with UVA1 and 13.70 with NB-UVB. The rates of patients achieving an IGA score of 0/1 persistent for at least 6 months were 33% with UVA1 and 28% with NB-UVB, and the rates with an EASI90 improvement were 10...
May 5, 2023: Journal of Clinical Medicine
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