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https://www.readbyqxmd.com/read/27883996/phototherapy-with-narrow-band-uvb-in-adult-guttate-psoriasis-results-and-patient-assessment
#1
Montserrat Fernández-Guarino, Sonsoles Aboín-González, Diana Velázquez, Lucia Barchino, Natividad Cano, Pablo Lázaro
BACKGROUND: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB). OBJECTIVE: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis. MATERIAL AND METHODS: We carried out a prospective, open, and observational study. Patients over 18 years with more than 5% of body surface area affected were included. The PASI was assessed prior to and after treatment...
November 25, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27828628/c-reactive-protein-serum-level-in-patients-with-psoriasis-before-and-after-treatment-with-narrow-band-ultraviolet-b
#2
Mahmoud Farshchian, Akram Ansar, Mohammadreza Sobhan, Valiollah Hoseinpoor
Background: C-reactive protein is an inflammatory biomarker and its level increases in the serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index score. Objective: The aim of this study was to assess the decrement of serum C-reactive protein level with narrow-band ultraviolet B (NB-UVB) therapy. Methods: C-reactive protein serum levels in psoriasis patients were measured before and after treatment with NB-UVB and the data were analyzed in relation to the Psoriasis Area and Severity Index score improvement...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27818365/fractional-co2-lasers-contribute-to-the-treatment-of-stable-non-segmental-vitiligo
#3
Jinping Yuan, Hongqiang Chen, Ru Yan, Shaoshan Cui, Yuan-Hong Li, Yan Wu, Xing-Hua Gao, Hong-Duo Chen
BACKGROUND: Stable non-segmental vitiligo is often resistant to conventional therapies. OBJECTIVES: The purpose of this study was to investigate the effect of three types of fractional lasers in the treatment of stable non-segmental vitiligo. MATERIALS & METHODS: Twenty patients were enrolled in the study. The vitiligo lesions of each patient were divided into four treatment parts, and all parts were treated with narrowband ultraviolet-B (NB-UVB)...
November 4, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27699880/impact-of-uva-on-pruritus-during-uva-b-phototherapy-of-inflammatory-skin-diseases-a-randomized-double-blind-study
#4
Julia-Tatjana Maul, Lorenz Kretschmer, Florian Anzengruber, Andrew Pink, Carla Murer, Lars E French, Günther F L Hofbauer, Alexander A Navarini
BACKGROUND: Narrowband (TL-01) UVB phototherapy (UVB nb) is effective in treating inflammatory skin disease. The addition of UVA is traditionally advocated to reduce pruritus, but lacks evidence for this recommendation. OBJECTIVES: The aim of this study was to assess the effect of UVB nb and UVA phototherapy in combination compared against UVB nb monotherapy on pruritus, disease activity, and quality of life. METHODS: In this double-blind randomised clinical trial 53 patients suffering from inflammatory skin diseases with pronounced itching (Visual Analogue Scale (VAS) for pruritus ≥ 5) were randomised in to two treatment groups...
October 4, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27696531/effect-of-narrow-band-ultraviolet-b-phototherapy-as-monotherapy-or-combination-therapy-for-vitiligo-a-meta-analysis
#5
Ronghua Li, Meng Qiao, Xiaoyan Wang, Xintong Zhao, Qing Sun
BACKGROUND: The treatment of vitiligo is still one of the most difficult dermatological challenges, although there are many therapeutic options. Narrow band ultraviolet B (NB-UVB) phototherapy is considered to be a very important modality for generalized vitiligo. OBJECTIVE: The aim of this study was to explore whether a combination of NB-UVB and topical agents would be superior to NB-UVB alone for treating vitiligo. METHODS: We searched the electronic databases such as PUBMED, EMBASE, Cochrane Library and Web of Science...
October 1, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27627998/repigmentation-patterns-induced-by-nb-uvb-and-their-relationship-with-melanocytic-migration-and-proliferation-in-vitiligo
#6
Juan Pablo Castanedo-Cázares, Juan Diego Cortés-García, Cornelia Fuentes-Ahumada, Karla Martinez-Rosales, Bertha Torres-Álvarez
BACKGROUND/PURPOSE: Vitiligo is the most commonly acquired depigmentation disorder of the skin and is characterized by the destruction of melanocytes. Ultraviolet phototherapy with narrow band (UVB-NB) induces proliferation, differentiation, maturation, and migration of melanocytes. The clinical repigmentation is featured by follicular, marginal, and diffuse patterns. The aim of this study was to observe the process involved in the melanocyte migration and proliferation among these patterns and the unresponsive lesions following UVB-NB phototherapy...
September 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27617609/narrowband-uvb-induced-iatrogenic-polymorphous-light-eruption-a-case-and-suggestions-to-overcome-this-rare-complication
#7
Mio Nakamura, Tina Bhutani, John Ym Koo
Polymorphous light eruption (PMLE) is the most common photodermatosis characterized by pruritic papules and papulovesicles, which appear hours to days following ultraviolet (UV) exposure. Herein, the authors report successful treatment of generalized plaque psoriasis with Goeckerman regimen in a patient despite new onset iatrogenic PMLE following narrowband (NB) UVB therapy. Although further studies are necessary, this case suggests that the co-existence of psoriasis and PMLE should not prevent the use of phototherapy; phototherapy, especially as part of the Goeckerman regimen, remains a valuable treatment option for psoriasis in patients with PMLE...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27611118/simultaneous-improvement-and-worsening-of-vitiligo-lesions-during-the-course-of-nb-uvb-phototherapy-vitiligo-may-not-act-as-one-unit
#8
Tag Anbar, Amal Abdel-Rahman, Rehab Hegazy, Mohamed El-Khayyat, Maha Ragaie
Re-pigmentation and stabilization are the two ultimate goals of any re-pigmenting plan designed for vitiligo management. Furthermore, whether the improvement of some vitiligo lesions could be considered a guarantee for a similar response and/or stabilization of the rest of the lesions or not, remains to be clarified. To evaluate the behavior of non-segmental vitiligo (NSV), while on narrow band-ultraviolet B (NB-UVB) phototherapy. 25 patients with stable generalized NSV were included and received NB-UVB twice weekly...
September 9, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27594347/vitiligo-the-story-from-within-a-transmission-electron-microscopic-study-before-and-after-narrow-band-ultraviolet-b
#9
Marwa M Fawzy, Zeinab M El Maadawi, Rehab A Hegazy, Nesrin S Abd El Fatah
Melanocyte loss is the main feature of vitiligo, but evidence refers to pathological multiplayers. Transmission electron microscopy was utilized to further explore vitiligo before and after narrow-band ultraviolet B (NB-UVB) therapy. Skin biopsies were retrieved from lesional and perilesional skin and compared to normal control skin. Sections were examined for melanocytes and keratinocytes and the number of melanosomes and thickness of basal lamina were measured. In lesional skin, keratinocytes revealed two types of degeneration with a significant increase in the mean thickness of basal lamina and decrease in the number of melanosomes...
September 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#10
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
September 3, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27552149/tacalcitol-a-useful-adjunct-to-narrow-band-ultraviolet-b-phototherapy-in-vitiligo
#11
Priyadarshini Sahu, Vijay Kumar Jain, Kamal Aggarwal, Sarabjit Kaur, Surabhi Dayal
BACKGROUND: Phototherapy especially narrow-band UV-B (NBUVB) has been considered as mainstay of therapy in nonsegmental vitiligo (generalized type). Topical tacalcitol has also been claimed to be effective, either as monotherapy or as combination therapy. PURPOSE: Comparison of clinical efficacy and safety of NBUVB in combination with topical tacalcitol vs. NBUVB alone in vitiligo. MATERIAL & METHODS: Thirty patients with symmetrical vitiliginous lesions were enrolled for 24 weeks...
September 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27502793/phototherapy-for-pityriasis-lichenoides-in-the-pediatric-population-a-review-of-the-published-literature
#12
REVIEW
Eric Laurent Maranda, Megan Smith, Austin H Nguyen, Vivek N Patel, Lawrence A Schachner, Jimenez J Joaquin
BACKGROUND: Pityriasis lichenoides (PL) is a dermatologic disorder that manifests in either the acute (pityriasis lichenoides et varioliformis acuta) or the chronic form (pityriasis lichenoides chronica, also known as parapsoriasis chronica). Traditional first-line therapy consists of corticosteroids or antibiotics; however, these treatments are often accompanied with multiple side effects and may be ineffective. OBJECTIVE: The goal of this study was to review the use of phototherapy for treating PL in the pediatric population...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27356486/combined-therapy-for-resistant-vitiligo-lesions-nb-uvb-microneedling-and-topical-latanoprost-showed-no-enhanced-efficacy-compared-to-topical-latanoprost-and-nb-uvb
#13
Andrija Stanimirovic, Maja Kovacevic, Igor Korobko, Mirna Šitum, Torello Lotti
Vitiligo is depigmenting disorder of the skin and mucous membranes but despite various therapeutic options, complete and satisfactory treatment of vitiligo still remains a challenge. Therapeutic success also varies depending on the localization of lesions; hands and bony prominents are considered to be resistant to treatment. We investigated feasibility of treating resistant bilateral symmetrical vitiligo vulgaris and acrofacialis lesions with combination of narrowband UVB and topical prostaglandins (0.005% latanoprost solution) with or without Dermaroller 0...
September 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27353865/narrow-band-uvb-phototherapy-and-psoralen-ultraviolet-a-photochemotherapy-in-the-treatment-of-cutaneous-mastocytosis-a-study-in-20-patients
#14
Valeria Brazzelli, Sara Grassi, Serena Merante, Vincenzo Grasso, Rachele Ciccocioppo, Grazia Bossi, Giovanni Borroni
BACKGROUND: In mastocytosis, the skin is almost invariably involved, and cutaneous symptoms deeply affect patients' quality of life. METHODS: A retrospective observational analysis of patients affected by cutaneous mastocytosis (CM) and indolent systemic mastocytosis (ISM) treated with phototherapy/photochemotherapy (PUVA or NB-UVB) has been conducted. For each patient, total numbers of PUVA or NB-UVB exposures, the cumulative UV dose (J/cm(2) ), serum tryptase profile, and pruritus, before and after treatment, according to the visual analogue scale (VAS) were considered...
September 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27314537/the-effect-of-phototherapy-on-systemic-inflammatory-process-in-patients-with-plaque-psoriasis
#15
Aleksandra Batycka-Baran, Petra Besgen, Ronald Wolf, Jacek C Szepietowski, Joerg C Prinz
Psoriasis is a common, chronic immune-mediated inflammatory disease. The inflammatory process in psoriasis has systemic effects and may influence the development of psoriatic comorbidities. The systemic action of phototherapy in patients with psoriasis has been so far poorly elucidated. We aimed to investigate the expression of genes encoding selected psoriasis-related cytokines in peripheral blood mononuclear cells (PBMCs) isolated from patients with psoriasis before and after treatment with phototherapy. 17 patients with mild to moderate plaque psoriasis were treated with narrow band-UVB (NB-UVB), 8 patients with moderate to severe plaque psoriasis with bath-psoralen-ultraviolet A therapy (PUVA)...
August 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27261977/oral-chinese-herbal-medicine-in-combination-with-phototherapy-for-vitiligo-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Yu-Jung Chen, Yi-Yang Chen, Ching-Yuan Wu, Ching-Chi Chi
AIMS: The aim of this study was to assess the effects of oral Chinese herbal medicine (CHM) combined with phototherapy for vitiligo. METHODS: We undertook a meta-analysis of relevant randomized controlled trials (RCTs) and searched eight bibliographic databases from inception to December 2015. RESULTS: A total of 5 RCTs with 513 participants which assessed the efficacy of oral CHM in combination with narrow-band ultraviolet B (NB-UVB) in treating vitiligo were included...
June 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27258736/phototherapy-using-narrowband-ultraviolet-b-and-psoralen-plus-ultraviolet-a-is-beneficial-in-steroid-dependent-antihistamine-refractory-chronic-urticaria-a-randomized-prospective-observer-blinded-comparative-study
#17
A Bishnoi, D Parsad, K Vinay, M S Kumaran
BACKGROUND: Literature on the efficacy of phototherapy in steroid-dependent antihistamine-refractory chronic urticaria (CRU) is limited. OBJECTIVES: To assess and compare the efficacy of psoralen plus ultraviolet A (PUVA) and narrowband ultraviolet B (NB-UVB) in steroid-dependent CRU. METHODS: In this randomized, prospective observer-blinded comparative study, 50 patients with steroid-dependent CRU (6 months of spontaneous urticaria with no response after 3 consecutive months of antihistamines and steroid dependence) were administered either PUVA (group A) or NB-UVB (group B) for 90 days, with a post-treatment follow-up of 90 days...
June 3, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27195053/local-corticosterone-activation-by-11%C3%AE-hydroxysteroid-dehydrogenase-1-in-keratinocytes-the-role-in-narrow-band-uvb-induced-dermatitis
#18
Saori Itoi-Ochi, Mika Terao, Hiroyuki Murota, Ichiro Katayama
Keratinocytes are known to synthesize cortisol through activation of the enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). To confirm the function of 11β-HSD1 in keratinocytes during inflammation in vivo, we created keratinocyte-specific-11β-HSD1 knockout mice (K5-Hsd11b1-KO mice) and analyzed the response to narrow-band ultraviolet B (NB-UVB) irradiation. Firstly, we measured the mRNA and protein levels of 11β-HSD1 following NB-UVB irradiation and found that the expression of 11β-HSD1 in keratinocytes of mouse ear skin was enhanced at 3 and 24 hours after 250 mJ/cm(2), 500 mJ/cm(2), 1 J/cm(2), and 2 J/cm(2) NB-UVB irradiation...
January 2016: Dermato-endocrinology
https://www.readbyqxmd.com/read/27193800/dermoscopic-and-immunohistochemical-changes-in-acquired-melanocytic-nevi-following-narrow-band-ultraviolet-b-therapy
#19
Hesham Zaher, Dalia Bassiouny, Rania Abdel Hay, Nesrin Samir, Nanees Ragab, Safinaz Sayed
BACKGROUND: Acquired melanocytic nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to narrow-band ultraviolet B (NB-UVB) radiation. OBJECTIVE: To study the morphological, dermoscopic and immunohistochemical changes in AMN following NB-UVB radiation. METHODS: Suberythemogenic NB-UVB sessions were delivered to 40 patients with AMN. For each patient, a minimum of 2 nevi were selected. One nevus was surgically removed from each patient prior to sessions as control; for the other nevus, dermoscopic images were captured before and after NB-UVB sessions...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27075746/effect-of-a-308-nm-excimer-laser-on-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#20
Chang Taek Oh, Tae-Rin Kwon, Joon Seok, Eun Ja Choi, Soon Re Kim, Yu-Jin Jang, Seog Kyun Mun, Chan Woong Kim, Sungeun Lee, Jongmin Lee, Myeung Nam Kim, Sun Young Choi, Beom Joon Kim
BACKGROUND AND OBJECTIVE: Atopic dermatitis (AD) is a common inflammatory skin disease that can affect all age groups. It has a relapsing course, which dramatically affects the quality of life of patients. A 308-nm excimer laser has been reported to be a safe and effective treatment for inflammatory skin diseases, although the range of potential application has not been fully explored. The purpose of this study was to evaluate the therapeutic effects of a 308-nm laser on AD-like skin lesions in NC/Nga mice...
August 2016: Lasers in Surgery and Medicine
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