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https://www.readbyqxmd.com/read/28324710/dual-substrate-limitation-modeling-and-implications-for-mainstream-deammonification
#1
Heather A Stewart, Ahmed Al-Omari, Charles Bott, Haydee De Clippeleir, Chunyang Su, Imre Takacs, Bernhard Wett, Arash Massoudieh, Sudhir Murthy
Substrate limitation occurs frequently in wastewater treatment and knowledge about microbial behavior at limiting conditions is essential for the use of biokinetic models in system design and optimization. Monod kinetics are well-accepted for modeling growth rates when a single substrate is limiting, but several models exist for treating two or more limiting substrates simultaneously. In this study three dual limitation models (multiplicative, minimum, and Bertolazzi) were compared based on experiments using nitrite-oxidizing bacteria (limited by dissolved oxygen and nitrite) and ANaerobic AMMonia-OXidizing bacteria or Aanammox (limited by ammonium and nitrite) within mixed liquor from deammonification pilots...
March 9, 2017: Water Research
https://www.readbyqxmd.com/read/28323476/state-level-progress-in-reducing-the-black-white-infant-mortality-gap-united-states-1999-2013
#2
Joedrecka S Brown Speights, Samantha Sittig Goldfarb, Brittny A Wells, Leslie Beitsch, Robert S Levine, George Rust
OBJECTIVES: To assess state-level progress on eliminating racial disparities in infant mortality. METHODS: Using linked infant birth-death files from 1999 to 2013, we calculated state-level 3-year rolling average infant mortality rates (IMRs) and Black-White IMR ratios. We also calculated percentage improvement and a projected year for achieving equality if current trend lines are sustained. RESULTS: We found substantial state-level variation in Black IMRs (range = 6...
March 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28314613/improved-image-quality-with-simultaneously-reduced-radiation-exposure-knowledge-based-iterative-model-reconstruction-algorithms-for-coronary-ct-angiography-in-a-clinical-setting
#3
Florian André, Philipp Fortner, Mani Vembar, Dirk Mueller, Wolfram Stiller, Sebastian J Buss, Hans-Ulrich Kauczor, Hugo A Katus, Grigorios Korosoglou
BACKGROUND: The aim of this study was to assess the potential for radiation dose reduction using knowledge-based iterative model reconstruction (K-IMR) algorithms in combination with ultra-low dose body mass index (BMI)-adapted protocols in coronary CT angiography (coronary CTA). METHODS: Forty patients undergoing clinically indicated coronary CTA were randomly assigned to two groups with BMI-adapted (I: <25.0 kg/m(2), II: <28.0 kg/m(2), III: <30.0 kg/m(2), IV: ≥30...
February 23, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28294664/-a-giant-inflammatory-fibroid-polyp-of-the-esophagus
#4
Balázs Vincze, Péter Mezei, János Hanyik, Sándor Almássy, Károly Gyáni, Géza Szűcs, Imre Tóth
Inflammatory fibroid polyp (IFP) is an uncommon benign tumor of the gastrointestinal tract. IFP in the esophagus is very rare, in particular in giant size. A case of a 63 year old woman with a 13 × 7 × 4.5 cm polyp originated of the lower third of the oesophagus is presented. Her esophageal polyp extended proximally from the level of the tracheal bifurcation, prolapsing through the cardia as well as the herniated stomach, and entered distally into the abdominal part of the stomach. Resection of the polyp was performed via a right oesophago-gastrotomy...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28294127/orai2-modulates-store-operated-calcium-entry-and-t-cell-mediated-immunity
#5
Martin Vaeth, Jun Yang, Megumi Yamashita, Isabelle Zee, Miriam Eckstein, Camille Knosp, Ulrike Kaufmann, Peter Karoly Jani, Rodrigo S Lacruz, Veit Flockerzi, Imre Kacskovics, Murali Prakriya, Stefan Feske
Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels is critical for lymphocyte function and immune responses. CRAC channels are hexamers of ORAI proteins that form the channel pore, but the contributions of individual ORAI homologues to CRAC channel function are not well understood. Here we show that deletion of Orai1 reduces, whereas deletion of Orai2 increases, SOCE in mouse T cells. These distinct effects are due to the ability of ORAI2 to form heteromeric channels with ORAI1 and to attenuate CRAC channel function...
March 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28293190/gaba-selank-and-olanzapine-affect-the-expression-of-genes-involved-in-gabaergic-neurotransmission-in-imr-32-cells
#6
Elena Filatova, Anastasiya Kasian, Timur Kolomin, Ekaterina Rybalkina, Anelya Alieva, Lyudmila Andreeva, Svetlana Limborska, Nikolay Myasoedov, Galina Pavlova, Petr Slominsky, Maria Shadrina
Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability to affect the performance of the GABAergic system. To test this hypothesis, we studied the changes in expression of 84 genes involved in the functioning of the GABAergic system and in the processes of neurotransmission in the culture of neuroblastoma IMR-32 cells using qPCR method...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28291052/first-line-antiretroviral-treatment-outcomes-and-durability-in-hiv-infectedchildren-treatedthrough-theuniversal-coverage-health-program-in-thailand
#7
Sirinya Teeraananchai, Torsak Bunupuradah, Thanyawee Puthanakit, Stephen J Kerr, Kiat Ruxrungtham, Suchada Chaivooth, Sorakij Bhakeecheep, Matthew G Law, Kulkanya Chokephaibulkit
BACKGROUND: We assessed the treatment outcomes on first-line antiretroviral therapy (ART), and factors associated with switching regimen in HIV-infected children treated through the universal coverage health program (UC) in Thailand. METHODS: Children aged <15 years at ART initiation who had been receiving ART for at least 6 months between 2008 and 2014 through UC were included in the analysis. The Kaplan-Meier method was used to estimate immunological recovery (IMR), immunologic failure (IMF) and virologic failure (VF)...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28289528/clinical-cardiac-regenerative-studies-in-children
#8
REVIEW
Imre J Pavo, Ina Michel-Behnke
Although the incidence of pediatric heart failure is low, the mortality is relatively high, with severe clinical symptoms requiring repeated hospitalization or intensive care treatment in the surviving patients. Cardiac biopsy specimens have revealed a higher number of resident human cardiac progenitor cells, with greater proliferation and differentiation capacity, in the neonatal period as compared with adults, demonstrating the regeneration potential of the young heart, with rising interest in cardiac regeneration therapy in critically ill pediatric patients...
February 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28286420/hlbt-100-a-highly-potent-anti-cancer-flavanone-from-tillandsia-recurvata-l-l
#9
Henry I C Lowe, Ngeh J Toyang, Charah T Watson, Kenneth N Ayeah, Joseph Bryant
BACKGROUND: The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a top global priority. Our drug discovery approach is natural products based with a focus on plants. Tillandsia recurvata (L.) L. is one of the plants selected by our research team for further studies based on previous bioactivity findings on the anticancer activity of this plant...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28284946/neuronal-coding-of-auditory-sensorimotor-gating-in-medial-prefrontal-cortex
#10
Attila Tóth, Zoltán Petykó, Rita Gálosi, Imre Szabó, Kázmér Karádi, Ádám Feldmann, László Péczely, Veronika Kállai, Zoltán Karádi, László Lénárd
The medial prefrontal cortex (mPFC) is thought to be an essential brain region for sensorimotor gating. The exact neuronal mechanisms, however, have not been extensively investigated yet by delicate single unit recording methods Prepulse inhibition (PPI) of the startle response is a broadly used important tool to investigate the inhibitory processes of sensorimotor gating. The present study was designed to examine the neuronal mechanisms of sensorimotor gating in the mPFC in freely moving rats. In these experiments, the animals were subjected to both pulse alone and prepulse+pulse stimulations...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28283196/sustainable-food-processing-inspired-by-nature
#11
Wilbert Sybesma, Imre Blank, Yuan-Kun Lee
Here, we elaborate on the natural origin and use of enzymes and cultures in sustainable food processing. We also illustrate how enzymatically treated or fermented food can contribute to solving challenges involving nutrition and health, such as aging, malnutrition, obesity, and allergy.
March 7, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28282432/metabolic-crosstalk-between-membrane-and-storage-lipids-facilitates-heat-stress-management-in-schizosaccharomyces-pombe
#12
Mária Péter, Attila Glatz, Péter Gudmann, Imre Gombos, Zsolt Török, Ibolya Horváth, László Vígh, Gábor Balogh
Cell membranes actively participate in stress sensing and signalling. Here we present the first in-depth lipidomic analysis to characterize alterations in the fission yeast Schizosaccharomyces pombe in response to mild heat stress (HS). The lipidome was assessed by a simple one-step methanolic extraction. Genetic manipulations that altered triglyceride (TG) content in the absence or presence of HS gave rise to distinct lipidomic fingerprints for S. pombe. Cells unable to produce TG demonstrated long-lasting growth arrest and enhanced signalling lipid generation...
2017: PloS One
https://www.readbyqxmd.com/read/28282397/evaluation-of-the-performance-of-national-health-systems-in-2004-2011-an-analysis-of-173-countries
#13
Daxin Sun, Haksoon Ahn, Tomas Lievens, Wu Zeng
In an effort to improve health service delivery and achieve better health outcomes, the World Health Organization (WHO) has called for improved efficiency of health care systems to better use the available funding. This study aims to examine the efficiency of national health systems using longitudinal country-level data. Data on health spending per capita, infant mortality rate (IMR), under 5 mortality rate (U5MR), and life expectancy (LE) were collected from or imputed for 173 countries from 2004 through 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28282259/study-on-the-pulmonary-delivery-system-of-apigenin-loaded-albumin-nanocarriers-with-antioxidant-activity
#14
Zsófia Edit Pápay, Annamária Kósa, Béla Böddi, Zahra Merchant, Imran Y Saleem, Mohammed Gulrez Zariwala, Imre Klebovich, Satyanarayana Somavarapu, István Antal
BACKGROUND: Respiratory diseases are mainly derived from acute and chronic inflammation of the alveoli and bronchi. The pathophysiological mechanisms of pulmonary inflammation mainly arise from oxidative damage that could ultimately lead to acute lung injury. Apigenin (Api) is a natural polyphenol with prominent antioxidant and anti-inflammatory properties in the lung. Inhalable formulations that consist of nanoparticles (NPs) have several advantages over other administration routes, and therefore, this study investigated the application of apigenin-loaded bovine serum albumin nanoparticles (BSA-Api-NPs) for pulmonary delivery...
March 10, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28275901/diagnosis-of-small-posterior-fossa-stroke-on-brain-ct-effect-of-iterative-reconstruction-designed-for-brain-ct-on-detection-performance
#15
Taihei Inoue, Takeshi Nakaura, Morikatsu Yoshida, Koichi Yokoyama, Kenichiro Hirata, Masafumi Kidoh, Seitaro Oda, Daisuke Utsunomiya, Kazunori Harada, Yasuyuki Yamashita
OBJECTIVES: In this study, we aimed to determine whether iterative model reconstruction designed for brain CT (IMR-neuro) would improve the accuracy of posterior fossa stroke diagnosis on brain CT. METHODS: We enrolled 37 patients with ischaemic stroke in the posterior fossa and 37 patients without stroke (controls). Using axial images reconstructed using filtered back-projection (FBP) and IMR-neuro, we compared the CT numbers in infarcted areas, image noise in the pons, and contrast-to-noise ratios (CNRs) of infarcted and non-infarcted areas on scans subjected to IMR-neuro and FBP...
March 8, 2017: European Radiology
https://www.readbyqxmd.com/read/28274519/regional-heterogeneity-in-the-mitral-valve%C3%A2-apparatus-in-patients-with-ischemic%C3%A2-mitral-regurgitation
#16
Feroze Mahmood, Ziyad O Knio, Lu Yeh, Rabia Amir, Robina Matyal, Azad Mashari, Robert C Gorman, Joseph H Gorman, Kamal R Khabbaz
BACKGROUND: Apical displacement of the coaptation point of the mitral valve (MV) in response to ischemic mitral regurgitation (IMR) represents remodeling of the MV apparatus. Whereas it implies chronicity, it lacks specificity in discriminating normal from a significantly remodeled MV apparatus. Regional aspects of MV remodeling have shown superior value over global remodeling in predicting recurrence after MV repair for IMR. Quite possibly, presence of specific regional changes in MV geometry that are unique to chronic IMR patients could also be used to diagnose the presence and track progression of remodeling...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28260192/polyphyllin-d-a-steroidal-saponin-in-paris-polyphylla-induces-apoptosis-and-necroptosis-cell-death-of-neuroblastoma-cells
#17
Shunsuke Watanabe, Tatuya Suzuki, Fujio Hara, Toshihiro Yasui, Naoko Uga, Atuki Naoe
PURPOSE: Neuroblastoma is a refractory pediatric malignant solid tumor. The previous studies demonstrated that Polyphyllin D, the main constituent of Paris polyphylla, a traditional Chinese medicine, exerts an anti-tumor effect on many tumors. However, its effects against neuroblastomas are unclear. METHODS: We examined the anti-tumor effect of polyphyllin D in human neuroblastoma using IMR-32 and LA-N-2 cells, which exhibit MYCN gene amplification, and NB-69 cells, which do not exhibit MYCN gene amplification...
March 4, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28254988/draft-genome-sequence-of-salmonellaenterica-serovar-typhi-imr_tp298-15-a-strain-with-intermediate-susceptibility-to-ciprofloxacin-isolated-from-a-typhoid-outbreak
#18
Norazah Ahmad, Shirley Yi Fen Hii, Rohaidah Hashim, Rahizan Issa
Salmonella enterica serovar Typhi with reduced susceptibility to ciprofloxacin is increasingly being reported globally. An outbreak caused by Salmonella Typhi with decreased ciprofloxacin susceptibility has not been reported before in Malaysia. We present here the annotated draft genome of a Salmonella Typhi strain involved in a typhoid outbreak.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28249240/identification-of-novel-dual-specificity-phosphatase-26-inhibitors-by-a-hybrid-virtual-screening-approach-based-on-pharmacophore-and-molecular-docking
#19
Ji-Xia Ren, Zhong Cheng, Yu-Xin Huang, Jing-Feng Zhao, Peng Guo, Zhong-Mei Zou, Yong Xie
Dual-specificity phosphatase 26 (DUSP26) has recently emerged as a target for treatment of human cancers. However, only two small-molecule inhibitors of DUSP26 are known so far, namely NSC-87877 and ethyl-3, 4-dephostatin. DUSP26 contains an N-terminal region (residues 1-60) and a conserved C-terminal catalytic domain (residues 61-211, DUSP26-C). The crystal structure of DUSP26-C, showing a catalytically inactive conformation of the active site, was reported in a previous study. However, the detailed catalytic mechanism of DUSP26 cannot be described based on that structure...
February 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28248256/integrated-proteomic-and-transcriptomic-based-approaches-to-identifying-signature-biomarkers-and-pathways-for-elucidation-of-daoy-and-uw228-subtypes
#20
Roger Higdon, Jessie Kala, Devan Wilkins, Julia Fangfei Yan, Manveen K Sethi, Liang Lin, Siqi Liu, Elizabeth Montague, Imre Janko, John Choiniere, Natali Kolker, William S Hancock, Eugene Kolker, Susan Fanayan
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Patient survival has remained largely the same for the past 20 years, with therapies causing significant health, cognitive, behavioral and developmental complications for those who survive the tumor. In this study, we profiled the total transcriptome and proteome of two established MB cell lines, Daoy and UW228, using high-throughput RNA sequencing (RNA-Seq) and label-free nano-LC-MS/MS-based quantitative proteomics, coupled with advanced pathway analysis...
February 3, 2017: Proteomes
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