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Anna Pratima G Nikalje, Pramod Gawhane, Shailee Tiwari, Jaiprakash Sangshetti, Manoj Damale
In this work, a new series of diethyl ((1H-indole-3-yl)((5-phenyl-1,3,4-thiadiazole-2- yl)amino)methyl)phosphonate derivatives 6(a-j) were designed and synthesized in Ultrasound by green protocol using Kabachnik-Fields reaction. The structures of the synthesized compounds were confirmed by spectral analysis such as elemental analyses, IR, 1H NMR, 13C NMR, 31P NMR and mass spectra. The synthesized compounds 6(a-j) were appraised for their in vitro anticancer activity against human cancer cell lines such as SK-MEL-2 (melanoma), IMR-32 (Neuroblastoma), HT-29(Colon) and also on normal murine embryonic fibroblast NIH/3T3 by Sulforhodamine B (SRB) assay, using Adriamycin as a standard drug...
April 17, 2018: Anti-cancer Agents in Medicinal Chemistry
Giancarlo Mari, Zoran Bursac, Patricia Jean Goedecke, Ramasubbareddy Dhanireddy
Objective . The objective of this study was to determine factors contributing to improvements in infant mortality rates (IMR) and composite morbidity-mortality in very-low-birth-weight (VLBW) infants after initiating a new perinatal program in 2009 at Regional One Health (ROH). VLBW infants account for 67% of infant deaths. Design . This is a pre-/postintervention cohort study of prospectively gathered data. Population . VLBW infants delivered at ROH during the 2004 to 2015 study period. Setting . ROH is a Regional Perinatal Center affiliated with the University of Tennessee Health Science Center...
2018: Global Pediatric Health
Edit Mikó, András Vida, Tünde Kovács, Gyula Ujlaki, György Trencsényi, Judit Márton, Zsanett Sári, Patrik Kovács, Anita Boratkó, Zoltán Hujber, Tamás Csonka, Péter Antal-Szalmás, Mitsuhiro Watanabe, Imre Gombos, Balazs Csoka, Borbála Kiss, László Vígh, Judit Szabó, Gábor Méhes, Anna Sebestyén, James J Goedert, Péter Bai
Our study aimed at finding a mechanistic relationship between the gut microbiome and breast cancer. Breast cancer cells are not in direct contact with these microbes, but disease could be influenced by bacterial metabolites including secondary bile acids that are exclusively synthesized by the microbiome and known to enter the human circulation. In murine and bench experiments, a secondary bile acid, lithocholic acid (LCA), reduced cancer cell proliferation (by 10-20%) and VEGF production (by 37%), aggressiveness and metastatic potential of primary tumors through inducing mesenchymal-to-epithelial transition, increased antitumor immune response, OXPHOS and the TCA cycle...
April 12, 2018: Biochimica et Biophysica Acta
Rita Könye, Gergő Tóth, Anna Sólyomváry, Zsolt Mervai, Moritz Zürn, Kornélia Baghy, Ilona Kovalszky, Péter Horváth, Ibolya Molnár-Perl, Béla Noszál, Szabolcs Béni, Imre Boldizsár
While analyzing the fruit composition of nine European Cirsium species representing three sections (i.e., Cephalonoplos, Chamaeleon and Eriolepis), four lignans, three neolignans and three sesquineolignans were determined and used as chemotaxonomic markers. Among them, desmethyl balanophonin and desmethyl picrasmalignan were determined for the first time in the plant kingdom, as the main metabolites of the Chamaeleon section. Prebalanophonin and prepicrasmalignan, identified so far exclusively in C. eriophorum, were also confirmed in C...
April 10, 2018: Fitoterapia
Farrah El-Saafin, Cynthia Curry, Tao Ye, Jean-Marie Garnier, Isabelle Kolb-Cheynel, Matthieu Stierle, Natalie L Downer, Mathew P Dixon, Luc Negroni, Imre Berger, Tim Thomas, Anne K Voss, William Dobyns, Didier Devys, Laszlo Tora
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA polymerase II (Pol II) preinitiation complex formation on all protein coding gene promoters and thus, be crucial for Pol II transcription. In a child with intellectual disability, mild microcephaly, corpus callosum agenesis and poor growth we identified a homozygous splice-site mutation in TAF8 (NM_138572.2:c.781-1G>A). Our data indicate that the patient's mutation generates a frame shift and an unstable TAF8 mutant protein with an unrelated C-terminus...
April 10, 2018: Human Molecular Genetics
Irena J Tatosian, Anna C Iacovino, Michael J Van Stipdonk
RATIONALE: In a previous study [Rapid Commun. Mass Spectrom. 2004; 18: 3028-3034], CID of [UVI O2 (ClO4 )]+ appeared to be influenced by the high levels of background H2 O in a quadrupole ion trap. The CID of the same species was re-examined here with the goal of determining whether additional, previously obscured dissociation pathways would be revealed under conditions in which the level of background H2 O was lower. METHODS: Water- and methanol-coordinated [UVI O2 (ClO4 )]+ precursor ions were generated by electrospray ionization...
April 12, 2018: Rapid Communications in Mass Spectrometry: RCM
Richard A Campbell, Andrea Tummino, Imre Varga, Olga Yu Milyaeva, Michael M Krycki, Shi-Yow Lin, Valerie Laux, Michael Haertlein, Victor Trevor Forsyth, Boris A Noskov
The application of protein deuteration and high flux neutron reflectometry has allowed a comparison of the adsorption properties of lysozyme at the air-water interface from dilute solutions with and without strong denaturants, urea and guanidine hydrochloride (GuHCl). The surface excess and adsorption layer thickness were resolved and complemented by images of the mesoscopic lateral morphology from Brewster angle microscopy. It was revealed that the thickness of the adsorption layer in the absence of added denaturants is less than the short axial length of the lysozyme molecule, which indicates deformation of the globules at the interface...
April 9, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Réka Petrovics, Bianka Söveges, Alexandra Egyed, Gergely Knorr, Attila Kormos, Tímea Imre, György Török, András Zeke, Éva Kocsmár, Gábor Lotz, Péter Kele, Krisztina Németh
One of the most popular means to follow interactions between bio(macro)molecules is Förster resonance energy transfer (FRET). There is large interest in widening the selection of fluorescent FRET pairs especially in the region of the red/far red range, where minimal autofluorescence is encountered. A set of bioorthogonally applicable fluorescent dyes, synthesized recently in our lab, were paired (Cy3T/Cy5T; Cy1A/Cy3T and Cy1A/CBRD1A) based on their spectral characteristics in order to test their potential in FRET applications...
April 9, 2018: Organic & Biomolecular Chemistry
Kyung Eun Lee, Joong Jae Kim, Hee-Jeong Jin, Siwoo Lee, Eun Bo Shim
[This corrects the article DOI: 10.1016/j.imr.2017.01.005.].
March 2018: Integrative Medicine Research
Masahiro Hoshino, Taishi Yonetsu, Tadashi Murai, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tetsumin Lee, Tsunekazu Kakuta
The aims of this study are to clarify whether discrepancies between angiographic and fractional flow reserve (FFR) measurements (visual-functional mismatch) influence coronary flow profiles after percutaneous coronary intervention. While current guidelines FFR-guided revascularization, clinical practice most commonly relies on angiographic evaluation, which may under- or over-estimate the functional relevance of the lesion. Our retrospective analysis involved 274 vessels from 264 patients with stable angina pectoris who underwent FFR, index of microvascular resistance, and coronary flow reserve (CFR) measurements before and after PCI...
April 7, 2018: Heart and Vessels
Szabolcs Fekete, Vida Sadat-Noorbakhsh, Cedric Schelling, Imre Molnár, Davy Guillarme, Serge Rudaz, Jean-Luc Veuthey
A generic liquid chromatographic method development workflow was developed and successfully applied to the analysis of phytocannabinoids and Cannabis sativa extracts. Our method development procedure consists in four steps: At the end, this method development workflow was performed in less than 4 days and minimizes the costs of the method development in liquid chromatography.
March 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
Kevin G Graves, Joseph B Muhlestein, Donald L Lappé, Raymond O McCubrey, Heidi T May, Stacey Knight, Viet T Le, Tami L Bair, Jeffrey L Anderson, Benjamin D Horne
BACKGROUND: The red cell distribution width (RDW) predicts mortality in numerous populations. The Intermountain Risk Scores (IMRS) predict patient outcomes using laboratory measurements including RDW. Whether the RDW or IMRS predicts in-hospital outcomes is unknown. METHODS: The predictive abilities of RDW and two IMRS formulations (the complete blood count [CBC] risk score [CBC-RS] or full IMRS using CBC plus the basic metabolic profile) were studied among percutaneous coronary intervention patients at Intermountain (males: N = 6007, females: N = 2165)...
April 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Shun Nishino, Nozomi Watanabe, Toshiyuki Kimura, Nehiro Kuriyama, Yoshisato Shibata
BACKGROUND: Little is known on the mechanism of acute ischemic mitral regurgitation (IMR) caused by sudden-onset left ventricular dysfunction in acute myocardial infarction (MI). We sought to investigate the mitral valve (MV) complex geometry in acute IMR in comparison with chronic IMR by 2-dimensional and 3-dimensional transthoracic echocardiography. METHODS AND RESULTS: Forty-four first-onset acute MI and 36 previous MI with ≥moderate IMR were examined by 2-dimensional/3-dimensional transthoracic echocardiography...
April 2018: Circulation. Cardiovascular Imaging
Yukari Kobayashi, Yuhei Kobayashi, Hyoung-Mo Yang, Sara Bouajila, Helen Luikart, Takeshi Nishi, Dong-Hyun Choi, Ingela Schnittger, Hannah A Valantine, Kiran K Khush, Alan C Y Yeung, Francois Haddad, William F Fearon
BACKGROUND: Invasively assessed coronary microvascular resistance early after heart transplantation predicts worse long-term outcome; however, little is known about the relationship between microvascular resistance, left ventricular function and outcomes in this setting. METHODS: A total of 100 cardiac transplant recipients had fractional flow reserve (FFR) and the index of microcirculatory resistance (IMR) measured in the left anterior descending artery and echocardiographic assessment of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) at 1 year after heart transplantation...
June 1, 2018: International Journal of Cardiology
Lajos Csincsik, Thomas J MacGillivray, Erin Flynn, Enrico Pellegrini, Giorgos Papanastasiou, Neda Barzegar-Befroei, Adrienne Csutak, Alan C Bird, Craig W Ritchie, Tunde Peto, Imre Lengyel
PURPOSE: To examine whether ultra-widefield (UWF) retinal imaging can identify biomarkers for Alzheimer's disease (AD) and its progression. METHODS: Images were taken using a UWF scanning laser ophthalmoscope (Optos P200C AF) to determine phenotypic variations in 59 patients with AD and 48 healthy controls at baseline (BL). All living participants were invited for a follow-up (FU) after 2 years and imaged again (if still able to participate). All participants had blood taken for genotyping at BL...
April 5, 2018: Ophthalmic Research
Helle Stentoft Dalum, Anna Kristine Waldemar, Lisa Korsbek, Carsten Hjorthøj, John Hagel Mikkelsen, Karin Thomsen, Kristen Kistrup, Mette Olander, Jane Lindschou, Merete Nordentoft, Lene Falgaard Eplov
OBJECTIVE: Illness Management and Recovery (IMR) is a psychosocial intervention with a recovery-oriented approach. The program has been evaluated in different settings; however evidence for the effects of IMR is still deficient. The aim of this trial was to investigate the benefits and harms of the IMR program compared with treatment as usual in Danish patients with schizophrenia or bipolar disorder. METHOD: The trial was designed as a randomized, assessor-blinded, multi-center, clinical trial investigating the IMR program compared with usual treatment...
2018: PloS One
Charlotte E Teunissen, Ming-Jang Chiu, Che-Chuan Yang, Shieh-Yueh Yang, Philip Scheltens, Henrik Zetterberg, Kaj Blennow
The 42 amino acid form of amyloid-β (Aβ42) plays a key role in the pathogenesis of Alzheimer's disease (AD) and is a core biomarker for the diagnosis of AD. Numerous studies have shown that cerebrospinal fluid (CSF) Aβ42 concentrations are decreased in AD, when measured by enzyme-linked immunosorbent assay (ELISA) and other conventional immunoassays. While most studies report no change in plasma Aβ42, independent studies using the immunomagnetic reduction (IMR) technique report an increase in plasma Aβ42 levels in AD...
2018: Journal of Alzheimer's Disease: JAD
D F He, M Y Liu, L J Zhang, C J Guo, Y P Chi, L Zhao, X J Zhang
Objective: To evaluate the impact of cardiovascular risk factors on index of microvascular resistance (IMR) and coronary flow reserve (CFR) and to explore the characteristics of IMR and CFR and the relationship between IMR and angiographic features in patients with intermediate coronary stenosis and chest pain. Methods: Fractional flow reserve (FFR), CFR, and IMR were measured in patients who underwent invasive coronary angiography with 40%-70% stenosis by visual assessment. All patients with FFR>0.75 were enrolled and grouped with the cut-off points of IMR≥25 and CFR≤2...
April 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
László Mangel, Tamás Tornóczky, Antal Zemplényi, Imre Boncz
The aim of this study was to survey the effects of the waiting time for the first oncology treatment in cancer diseases. By the analysis of 67 retrospective studies and reviews the numerical effects of treatment initiation time on survival were assessed. The "time factor" has a leading role on cancer types with aggressive biological behaviour, like breast cancer in younger age, testicular cancers, or head and neck tumours. However, a few days and reasonable delay to the first oncology intervention has no negative impact in numerous cancer diseases...
April 2018: Orvosi Hetilap
Joo Myung Lee, Hyun Kuk Kim, Kyung Seob Lim, Jun-Kyu Park, Ki Hong Choi, Jonghanne Park, Doyeon Hwang, Tae-Min Rhee, Jeong Hoon Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Joo-Yong Hahn, Bon-Kwon Koo, Myung Ho Jeong
OBJECTIVES: The aim of this study was to investigate the influence of microvascular damage in one vessel territory on invasively measured physiological parameters in the other vessel, using a porcine microvascular damage model. BACKGROUND: Although fractional flow reserve (FFR)-guided decision-making for the nonculprit stenosis in patients with acute myocardial infarction has been reported to be better than angiography-guided revascularization, there have been debates regarding the influence of microvascular dysfunction on measured FFR in nonculprit vessels...
March 22, 2018: JACC. Cardiovascular Interventions
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