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https://www.readbyqxmd.com/read/29042314/differential-distribution-and-function-of-gababrs-in-somato-dendritic-and-axonal-compartments-of-principal-cells-and-interneurons-in-cortical-circuits
#1
REVIEW
Ákos Kulik, Sam A Booker, Imre Vida
GABABRs are highly expressed in cortical circuits, controlling neuronal excitability and synaptic transmission in both principal cells and inhibitory interneurons. Light and electron microscopic studies confirmed the wide distribution of receptors and revealed cell type-specific quantitative differences in their cellular and subcellular distributions. At the subcellular level, GABABRs are abundant at the peri- and extrasynaptic membrane of somato-dendritic compartments and to lower levels in the axon terminals of both cortical excitatory principal cells and inhibitory interneurons...
October 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29030787/armillifer-infected-snakes-sold-at-congolese-bushmeat-markets-represent-an-emerging-zoonotic-threat
#2
Richard Hardi, Gergely Babocsay, Dennis Tappe, Mihály Sulyok, Imre Bodó, Lajos Rózsa
African pythons (Pythonidae) and large vipers (Bitis spp.) act as definitive hosts for Armillifer armillatus and Armillifer grandis parasites (Crustacea: Pentastomida) in the Congo Basin. Since the proportion of snakes in bushmeat gradually increases, human pentastomiasis is an emerging zoonotic disease. To substantiate the significance of this threat, we surveyed snakes offered for human consumption at bushmeat markets in the Kole district, Democratic Republic of the Congo, for the presence of adult pentastomids...
October 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29029466/a-comparative-study-of-anti-aging-properties-and-mechanism-resveratrol-and-caloric-restriction
#3
Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen, Gang Chen
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029436/xist-mir-139-axis-regulates-bleomycin-blm-induced-extracellular-matrix-ecm-and-pulmonary-fibrosis-through-%C3%AE-catenin
#4
Yichun Wang, Ying Liang, Junming Luo, Jing Nie, Huiming Yin, Qiong Chen, Jing Dong, Jixiang Zhu, Jiamei Xia, Wei Shuai
Pulmonary fibrosis (PF), characterized by the destruction of lung tissue architecture and the abnormal deposition of extracellular matrix (ECM) proteins, currently has no satisfactory treatment. In the present study, we investigated the hypothesis that XIST play a promotive role in bleomycin (BLM)-induced ECM and pulmonary fibrosis; XIST exerts its effect through miR-139 regulation. XIST expression was upregulated in lung tissues derived from BLM-induced mouse model of PF, and was positively correlated with β-catenin and ECM protein levels, respectively...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29025292/-brentuximab-vedotin-treatment-in-patients-with-relapsed-or-refractory-hodgkin-lymphoma-a-hungarian-retrospective-study
#5
Zsuzsa Molnár, László Imre Pinczés, Klára Piukovics, Ildikó Istenes, Krisztina Wolf, Zoltán Csukly, Árpád Szomor, Árpád Illés, Zsófia Miltényi
INTRODUCTION: The treatment of relapsed or refractory Hodgkin lymphoma is still a major therapeutic challenge. The use of brentuximab vedotin, an anti-CD30 antibody-drug conjugate, represents a promising approach for these patients, however clinical outcomes have not yet been evaluated in Hungary. AIM: Our aim was to assess the efficacy, safety and outcome of brentuximab vedotin treatment in Hungarian Hodgkin lymphoma patients. METHOD: In this retrospective case note review we enrolled patients at 6 clinical sites countrywide who were diagnosed with Hodgkin lymphoma and received brentuximab vedotin between 1 January 2013 and 31 December 2016...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29021609/a-cdk1-gradient-guides-surface-contraction-waves-in-oocytes
#6
Johanna Bischof, Christoph A Brand, Kálmán Somogyi, Imre Májer, Sarah Thome, Masashi Mori, Ulrich S Schwarz, Péter Lénárt
Surface contraction waves (SCWs) in oocytes and embryos lead to large-scale shape changes coupled to cell cycle transitions and are spatially coordinated with the cell axis. Here, we show that SCWs in the starfish oocyte are generated by a traveling band of myosin II-driven cortical contractility. At the front of the band, contractility is activated by removal of cdk1 inhibition of the RhoA/RhoA kinase/myosin II signaling module, while at the rear, contractility is switched off by negative feedback originating downstream of RhoA kinase...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28994679/ischemic-mitral-regurgitation
#7
REVIEW
Praveen Kerala Varma, Neethu Krishna, Reshmi Liza Jose, Ashish Narayan Madkaiker
Ischemic mitral regurgitation (IMR) is a frequent complication of left ventricular (LV) global or regional pathological remodeling due to chronic coronary artery disease. It is not a valve disease but represents the valvular consequences of increased tethering forces and reduced closing forces. IMR is defined as mitral regurgitation caused by chronic changes of LV structure and function due to ischemic heart disease and it worsens the prognosis. In this review, we discuss on etiology, pathophysiology, and mechanisms of IMR, its classification, evaluation, and therapeutic corrective methods of IMR...
October 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28989024/protein-kinase-c-downregulation-induces-senescence-via-foxo3a-inhibition-in-hct116-and-hek293%C3%A2-cells
#8
Jeong-Woo Park, Young-Hoon Lee, Young-Seuk Bae
We investigated the impact of protein kinase C (PKC) on cellular senescence. The PKC activity and expression of conventional PKC (cPKC) and atypical PKC (aPKC) isoforms decreased during replicative senescence in IMR-90 cells. Forced inhibition of cPKC or aPKC induced the activation of senescence markers, including senescence-associated β-galactosidase activity and reactive oxygen species (ROS)-p53-p21(Cip1/WAF1) axis in HCT116 and HEK293 cells. PKC inhibition triggered the nuclear exportation of FoxO3a via stimulation of AKT-mediated phosphorylation of FoxO3a, and thereby decreased the transcription of FoxO3a target genes...
October 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28986581/nucleosome-stability-measured-in-situ-by-automated-quantitative-imaging
#9
László Imre, Zoltán Simándi, Attila Horváth, György Fenyőfalvi, Péter Nánási, Erfaneh Firouzi Niaki, Éva Hegedüs, Zsolt Bacsó, Urbain Weyemi, Rebekka Mauser, Juan Ausio, Albert Jeltsch, William Bonner, László Nagy, Hiroshi Kimura, Gábor Szabó
Current approaches have limitations in providing insight into the functional properties of particular nucleosomes in their native molecular environment. Here we describe a simple and powerful method involving elution of histones using intercalators or salt, to assess stability features dependent on DNA superhelicity and relying mainly on electrostatic interactions, respectively, and measurement of the fraction of histones remaining chromatin-bound in the individual nuclei using histone type- or posttranslational modification- (PTM-) specific antibodies and automated, quantitative imaging...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28967266/-change-of-paradigm-in-the-surgical-treatment-of-metastatic-diseases-of-bone-part-i-bony-metastases-of-the-extremities-and-pelvis
#10
Miklós Szendrői, János Kiss, Tamás Perlaky, Imre Antal, Krisztián Szalay, Attila Szendrői
According to the statistical data of tumor registries the incidence of cancer has increased in the last decade, however the mortality shows only a slight change due to the new and effective multimodal treatments. The aim of our overview article is to present the changes in the survival of the metastatic patients, and to demonstrate which factors influence their prognosis. The improvement of survival resulted in a more active surgical role both in metastases of the bone of the extremities and the pelvis. We present a diagnostic flow chart and current options for the reconstruction of the different regions of the bone and skeleton, and we will discuss their potential advantages, disadvantages and complications...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28965850/trends-in-birth-weight-specific-and-adjusted-infant-mortality-rates-in-taiwan-between-2004-and-2011
#11
Fu-Wen Liang, Hung-Chieh Chou, Shu-Ti Chiou, Li-Hua Chen, Mei-Hwan Wu, Hung-Chi Lue, Tung-Liang Chiang, Tsung-Hsueh Lu
BACKGROUND: A yearly increase in the proportion of very low birth weight (VLBW) live births has resulted in the slowdown of decreasing trends in crude infant mortality rates (IMRs). In this study, we examined the trends in birth weight-specific as well as birth weight-adjusted IMRs in Taiwan. METHODS: We linked three nationwide datasets, namely the National Birth Reporting Database, National Birth Certification Registry, and National Death Certification Registry databases, to calculate the IMRs according to the birth weight category...
September 4, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28964888/egfr-her2-target-based-molecular-docking-analysis-in-vitro-screening-of-2-4-5-trisubstituted-imidazole-derivatives-as-potential-anti-oxidant-and-cytotoxic-agents
#12
Ramu Guda, Girijesh Kumar, Rajashekar Korra, Siripireddy Balaji, Govindu Dayakar, Rambabu Palabindela, Prabhakar Myadaraveni, Narsimha Reddy Yellu, Mamatha Kasula
In our endeavor towards the development of potent molecules for cancer diseases, we have designed and synthesized a series of 2,4,5-trisubstituted imidazole derivatives (B1-B24) and characterized by using various spectroscopic techniques. All these compounds are further evaluated for their in vitro anti-cancer, anti-oxidant activities and molecular docking studies against EGFR, HER2 protein receptors. The in vitro anti-cancer activity analysis reveals that compounds B11 and B16 were found to be effective scaffolds against the tested human cancer cell lines IMR-32, A549 and HeLa...
September 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28964798/phenotypic-clusters-predict-outcomes-in-a-longitudinal-interstitial-lung-disease-cohort
#13
Ayodeji Adegunsoye, Justin M Oldham, Jonathan H Chung, Steven M Montner, Cathryn Lee, Leah J Witt, Danielle Stahlbaum, Rene S Bermea, Lena W Chen, Scully Hsu, Aliya N Husain, Imre Noth, Rekha Vij, Mary E Strek, Matthew Churpek
BACKGROUND: The current interstitial lung disease (ILD) classification has overlapping clinical presentations and outcomes. Cluster analysis modeling is a valuable tool in identifying distinct clinical phenotypes in heterogeneous diseases. However, this approach has yet to be implemented in ILD. METHODS: Using cluster analysis, we identified novel ILD phenotypes among subjects from a longitudinal ILD cohort and stratified outcomes by phenotypic clusters compared to subgroups by current American Thoracic Society (ATS)/European Respiratory Society (ERS) ILD classification criteria...
September 27, 2017: Chest
https://www.readbyqxmd.com/read/28961271/multiplanar-strain-quantification-for-assessment-of-right-ventricular-dysfunction-and-non-ischemic-fibrosis-among-patients-with-ischemic-mitral-regurgitation
#14
Antonino Di Franco, Jiwon Kim, Sara Rodriguez-Diego, Omar Khalique, Jonathan Y Siden, Samantha R Goldburg, Neil K Mehta, Aparna Srinivasan, Mark B Ratcliffe, Robert A Levine, Filippo Crea, Richard B Devereux, Jonathan W Weinsaft
BACKGROUND: Ischemic mitral regurgitation (iMR) predisposes to right ventricular (RV) pressure and volume overload, providing a nidus for RV dysfunction (RVDYS) and non-ischemic fibrosis (NIF). Echocardiography (echo) is widely used to assess iMR, but performance of different indices as markers of RVDYS and NIF is unknown. METHODS: iMR patients prospectively underwent echo and cardiac magnetic resonance (CMR) within 72 hours. Echo quantified iMR, assessed conventional RV indices (TAPSE, RV-S', fractional area change [FAC]), and strain via speckle tracking in apical 4-chamber (global longitudinal strain [RV-GLS]) and parasternal long axis orientation (transverse strain)...
2017: PloS One
https://www.readbyqxmd.com/read/28957416/characterization-of-the-interactions-of-rabbit-neonatal-fc-receptor-fcrn-with-rabbit-and-human-igg-isotypes
#15
Bence Szikora, László Hiripi, Balázs Bender, Imre Kacskovics, Attila Iliás
Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG molecules. We analyzed the interactions of the rabbit and human FcRn with rabbit and human IgG isotypes using surface plasmon resonance assay. Similar to FcRn of other species, rabbit FcRn functions in pH-dependent manner, as it binds IgGs at pH 6...
2017: PloS One
https://www.readbyqxmd.com/read/28952963/amorphous-silicon-carbide-ultramicroelectrode-arrays-for-neural-stimulation-and-recording
#16
Felix Deku, Yarden Cohen, Alexandra Joshi-Imre, Aswini Kanneganti, Timothy Gardner, Stuart Cogan
OBJECTIVE: Foreign body response to indwelling cortical microelectrodes limits the reliability of neural stimulation and recording, particularly for extended chronic applications in behaving animals. The extent to which this response compromises the chronic stability of neural devices depends on many factors including the materials used in the electrode construction, the size, and geometry of the indwelling structure. Here, we report on the development of microelectrode arrays (MEAs) based on amorphous silicon carbide (a-SiC)...
September 27, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28951904/the-influence-of-penicillamine-cysteine-mutation-on-the-metal-complexes-of-peptides
#17
Ágnes Grenács, Norbert Lihi, Imre Sóvágó, Katalin Várnagy
N-Terminally free but C-terminally amidated peptides Pen-SSACS-NH2 and CSSA-Pen-S-NH2 containing l-penicillamine (Pen) in sequence have been synthesized and their nickel(ii), zinc(ii) and cadmium(ii) complexes were studied by potentiometric and spectroscopic measurements. This study is the first example of the synthesis and metal complexes of peptides containing penicillamine in a peptide sequence constructed from natural amino acids. The data were compared to those of the two cysteine counterparts, CSSACS-NH2...
October 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28950039/pharmacovigilance-assessment-of-immune-mediated-reactions-reported-for-checkpoint-inhibitor-cancer-immunotherapies
#18
Ayad K Ali, David E Watson
STUDY OBJECTIVE: Ipilimumab, pembrolizumab, and nivolumab are checkpoint inhibitors (CPI) that activate T cell-mediated immune response. CPI can provide durable benefits to some cancer patients with melanoma, renal cell cancer, non-small cell lung cancer, and a growing list of other cancers. However, CPI treatment is also associated with adverse immune-mediated reactions (IMR) that can be life-threatening. This pharmacovigilance analysis aims to characterize IMR signals in relation to CPI treatment...
September 26, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28942086/validation-of-a-52-gene-risk-profile-for-outcome-prediction-in-patients-with-idiopathic-pulmonary-fibrosis-an-international-multicentre-cohort-study
#19
Jose D Herazo-Maya, Jiehuan Sun, Philip L Molyneaux, Qin Li, Julian A Villalba, Argyrios Tzouvelekis, Heather Lynn, Brenda M Juan-Guardela, Cristobal Risquez, Juan C Osorio, Xiting Yan, George Michel, Nachelle Aurelien, Kathleen O Lindell, Melinda J Klesen, Miriam F Moffatt, William O Cookson, Yingze Zhang, Joe G N Garcia, Imre Noth, Antje Prasse, Ziv Bar-Joseph, Kevin F Gibson, Hongyu Zhao, Erica L Herzog, Ivan O Rosas, Toby M Maher, Naftali Kaminski
BACKGROUND: The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable. Clinical prediction tools are not accurate enough to predict disease outcomes. METHODS: We enrolled patients with IPF diagnosis in a six-cohort study at Yale University (New Haven, CT, USA), Imperial College London (London, UK), University of Chicago (Chicago, IL, USA), University of Pittsburgh (Pittsburgh, PA, USA), University of Freiburg (Freiburg im Breisgau, Germany), and Brigham and Women's Hospital-Harvard Medical School (Boston, MA, USA)...
September 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28941830/experimental-and-computational-study-of-the-effect-of-breath-actuated-mechanism-built-in-the-nexthaler-%C3%A2-dry-powder-inhaler
#20
Árpád Farkas, David Lewis, Tanya Church, Alan Tweedie, Francesca Mason, Allen E Haddrell, Jonathan P Reid, Alpár Horváth, Imre Balásházy
The breath-actuated mechanism (BAM) is a mechanical unit included in NEXThaler(®) with the role of delaying the emission of the drug until the inhalation flow rate of the patient is sufficiently high to detach the drug particles from their carriers. The main objective of this work was to analyse the effect of the presence of BAM on the size distribution of the emitted drug and its airway deposition efficiency and distribution. Study of the hygroscopic growth of the emitted drug particles and its effect on the deposition was another goal of this study...
September 21, 2017: International Journal of Pharmaceutics
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