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Chrysin AND Smad

Cornel Balta, Hildegard Herman, Oana Maria Boldura, Ionela Gasca, Marcel Rosu, Aurel Ardelean, Anca Hermenean
We investigated the protective effect of chrysin on chronic liver fibrosis in mice and the potential mechanism underlying TGF-β1-mediated hepatic stellate cells (HSCs) activation on fibrogenesis. Experimental fibrosis was established by intraperitoneal injection of mice with 20% v/v, 2 ml/kg CCl4 twice a week, for 7 weeks. Mice were orally treated with 3 doses of chrysin (50, 100 and 200 mg/kg) or with vehicle as control. For the assessment of the spontaneous reversion of fibrosis, CCl4 treated animals were investigated after two weeks of recovery time...
October 5, 2015: Chemico-biological Interactions
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