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urethral duplication

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https://www.readbyqxmd.com/read/28191791/urethral-duplication-type-influences-on-the-complications-rate-and-number-of-surgical-procedures
#1
Roberto Iglesias Lopes, Amilcar Martins Giron, Marcos Figueiredo Mello, Cristovao Machado Barbosa Neto, Joana Dos Santos, Paulo Renato Marcelo Moscardi, Victor Srougi, Francisco Tibor Denes, Miguel Srougi
INTRODUCTION: Urethral duplication is rare. Characterized by the presence of two urethral channels. This anomaly presents a great variety of clinical findings that depend on the type of duplication that often is associated with other anomalies. MATERIAL AND METHODS: We report thirteen boys with urethral duplication managed in our institution between 1988-2015. Clinical findings, associated anomalies, treatment of urethral duplication and our results are described...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28161406/glans-duplication-in-depth-review-and-proposal-of-a-new-classification
#2
REVIEW
Lisieux E Jesus, Samuel Dekermacher, Erica Lopes, Andreia P Bacon
BACKGROUND: Diphallia is a very uncommon malformation, and glans duplication (GD) is its rarest form. In this last group, patients normally present with esthetic/sexual complaints or obstructed voiding late in life after pubertal genital development. Associated malformations are uncommon and relatively mild in those cases. METHODS: After a case presented, we present herein an extensive review of GD, as the disease is rare, and there is very little about its treatment and there are diverse approaches to address the condition...
January 18, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28149748/extravasation-of-urine-associated-with-bilateral-complete-ureteral-duplication-vesicoureteral-reflux-and-benign-prostatic-hyperplasia
#3
Issei Suzuki, Kanya Kaga, Kohei Takei, Yuumi Tokura, Kazumasa Sakamoto, Daisaku Nishihara, Tomoya Mizuno, Hideo Yuki, Hironori Betsunoh, Hideyuki Abe, Masahiro Yashi, Yoshitatsu Fukabori, Tomonori Yamanishi, Takao Kamai
We report a rare case of extravasation of urine, which may be associated with bilateral complete ureteral duplication, vesicoureteral reflux (VUR), and benign prostatic hyperplasia (BPH). A 71-year-old male presented with a complaint of right abdominal pain. An extravasation of urine was noted, and was improved by indwelling urethral catheterization. Transurethral resection of the prostate and the endoscopic subureteral injection of dextanomer/hyaluronic acid were performed for the treatment of BPH and VUR, respectively...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28018807/urethral-duplication-with-two-hypospadic-meati-an-unusual-variant
#4
Joseph Rutherford Davidson, Naomi Jane Wright, Massimo Garriboli
Duplication of the urethra is a rare congenital anomaly, with approximately 300 cases reported in the literature. We report a unique case of this condition in a male infant. This case differs from the classical Effman type II-A2 duplication because of the presence of two hypospadic urethral meati, as opposed to a ventral or dorsal accessory meatus with a normally positioned distal urethra. The patient underwent a single-stage repair consisting of a proximal urethra-urethral anastomosis and distal urethral tubularization at 21 months of age with excellent results in terms of both function and cosmesis...
December 2016: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/27989796/altered-sox9-genital-tubercle-enhancer-region-in-hypospadias
#5
REVIEW
Rajini Sreenivasan, Christopher T Gordon, Sabina Benko, Robb de Iongh, Stefan Bagheri-Fam, Stanislas Lyonnet, Vincent Harley
Human mutations in the SOX9 gene or its regulatory region can disrupt testicular development, leading to disorders of sex development (DSDs). Our previous work involving the genomic analysis of isolated DSD patients revealed a 78kb minimal sex determining region (RevSex) far upstream of SOX9 that was duplicated in 46,XX and deleted in 46,XY DSDs. It was postulated that RevSex contains a gonadal enhancer. However, the most highly conserved sub-region within RevSex, called SR4, was neither responsive to sex determining factors in vitro nor active in the gonads of transgenic mice, suggesting that SR4 may not be functioning as a testicular enhancer...
October 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27912972/fate-of-males-with-urethral-y-duplication-40-year-long-follow-up-in-8-patients
#6
Mario Lima, Francesca Destro, Neil Di Salvo, Tommaso Gargano, Giovanni Ruggeri
PURPOSE: The spectrum of male urethral duplication is heterogeneous and it includes the Y-duplication. The malformation is rare and there is only a few case series reported in the literature. The management of Y-forms remains challenging for the surgeon and the long-term follow-up is still scarcely investigated. We report our 40-year experience in the management of patients with Y-duplication. MATERIALS AND METHODS: We conducted a restrospective analysis collecting information of patients with urethral Y-duplication treated at our department from April 1975 to April 2015...
November 17, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27890404/incomplete-urethral-duplication-associated-with-a-dermoid-cyst-in-a-dog-with-urinary-obstruction
#7
F Thierry, S Drew, J Del-Pozo, N Fernandez-Salesa, S Woods, G Stanzani, T Liuti
A 20-month-old male miniature dachshund was evaluated for a 10-week history of intermittent stranguria, pollakiuria, haematuria and obstructive urolithiasis. Retrograde urethrocystography revealed a subcutaneous saccular structure in the perineal area connected to the intrapelvic urethra associated with urolithiasis. After excision of the perineal saccular structure, microscopical examination confirmed the presence of transitional epithelium lining the diverticulum, with isolated submucosal smooth muscle bundles...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27887914/practical-and-functional-classification-of-the-double-urethra-a-variable-complex-and-fascinating-malformation-observed-in-20-patients
#8
M Lima, F Destro, M Maffi, D Persichetti Proietti, G Ruggeri
INTRODUCTION: Urethral duplication is a rare and variable malformation of the urinary tract, with non-univocal and complex management. In addition, different classification schemes have been proposed, but none have considered all the possible variants. OBJECTIVE: To report experience with the management of 20 urethral duplication patients and propose a classification of this anomaly. MATERIALS AND METHODS: A retrospective analysis collecting information regarding 20 patients (Table) with urethral duplication treated at a single institution over the past 40 years...
November 3, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27814383/adult-gli2-gli3%C3%AE-699-male-and-female-mice-display-a-spectrum-of-genital-malformation
#9
Fei He, Pedram Akbari, Rong Mo, Jennifer J Zhang, Chi-Chung Hui, Peter C Kim, Walid A Farhat
Disorders of sexual development (DSD) encompass a broad spectrum of urogenital malformations and are amongst the most common congenital birth defects. Although key genetic factors such as the hedgehog (Hh) family have been identified, a unifying postnatally viable model displaying the spectrum of male and female urogenital malformations has not yet been reported. Since human cases are diagnosed and treated at various stages postnatally, equivalent mouse models enabling analysis at similar stages are of significant interest...
2016: PloS One
https://www.readbyqxmd.com/read/27695215/coexisting-urogenital-anomaly-and-duodenal-atresia-in-two-atypical-holt-oram-syndrome
#10
Tuncer Ahmet Ali, Karavelio─člu Afra, Baskin Embleton Didem, Elmas Muhsin
Holt-Oram syndrome (HOS) is a rare autosomal dominant disorder, characterized by upper limb dysplasia and congenital cardiac defect. We report two cases with HOS, first associated with renal agenesis, coronal hypospadias, urethral duplication and second associated with duodenal atresia and horseshoe kidney that have not been reported in English literature.
October 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/27695207/scrotal-abscess-varied-etiology-associations-and-management
#11
Raghu S Ramareddy, Anand Alladi
AIM: To report a series of scrotal abscess, a rare problem, their etiology, and management. MATERIALS AND METHODS: A retrospective study of children who presented with scrotal abscess between January 2010 and March 2015, analyzed with respect to clinical features, pathophysiology of spread and management. RESULTS: Eight infants and a 3-year-old phenotypically male child presented with scrotal abscess as a result of abdominal pathologies which included mixed gonadal dysgenesis (MGD) [1]; three anorectal malformations with ectopic ureter [1], urethral stricture [1], and neurogenic bladder [1]; meconium peritonitis with meconium periorchitis [2], ileal atresia [1], and intra-abdominal abscess [1]; posturethroplasty for Y urethral duplication with metal stenosis [1] and idiopathic pyocele [1]...
October 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/27614119/urological-findings-in-beckwith-wiedemann-syndrome-with-chromosomal-duplications-of-11p15-5-evaluation-and-management
#12
Carmen C Tong, Kelly A Duffy, David I Chu, Dana A Weiss, Arun K Srinivasan, Douglas A Canning, Jennifer M Kalish
Beckwith-Wiedemann Syndrome (BWS) is an overgrowth disorder with various congenital anomalies. Although the most classic constellation includes macrosomia, macroglossia, and omphalocele, nephrourological findings are commonly associated with BWS. Clinical presentation is highly variable because of its complex molecular heterogeneity, which involves changes in DNA methylation and disruption of growth regulatory genes. We report 3 pediatric patients, ages 13 months to 3 years old, who presented with clinical features consistent with BWS...
February 2017: Urology
https://www.readbyqxmd.com/read/27522318/male-and-female-aphallia-associated-with-severe-urinary-tract-dysplasia
#13
Ariella A Friedman, Paul F Zelkovic, Edward F Reda, Israel Franco, Lane S Palmer
INTRODUCTION: Aphallia is exceedingly rare (1/30 million births). Previous reports have provided limited detail on associated urinary tract findings. OBJECTIVE: We reviewed urinary tract anomalies in two boys with aphallia (patients 1 and 2) and a girl with urinary tract dysplasia, a similar external appearance and lack of corporal tissue (patient 3), also consistent with aphallia. CASE REPORTS (FIGURE): Patients 1 and 2 both had a 46XY karyotype, bilateral descended testes in well-formed scrotums, and posterior skin tags containing rudimentary urethras...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27351325/reproducibility-of-leak-point-pressure-in-female-stress-urinary-incontinence
#14
Eu Chang Hwang, Sun Ouck Kim, Dong Deuk Kwon
PURPOSE: To assess the reproducibility of the Valsalva leak point pressure (VLPP) based on urodynamics in females with stress urinary incontinence (SUI). MATERIALS AND METHODS: From October 2008 to December 2009, 65 consecutive women with urodynamically confirmed SUI underwent duplicate VLPP measurements. The intra-individual reproducibility of the VLPP recording obtained by one urologist was determined. The two observations were separated by a 10-min interval. RESULTS: The differences between the repeated measurements were not significant (initial vs...
2016: Urology Journal
https://www.readbyqxmd.com/read/27317623/results-of-distal-hypospadias-repair-after-pediatric-urology-fellowship-training-a-comparison-of-junior-surgeons-with-their-mentor
#15
N C Bush, T D Barber, D Dajusta, J C Prieto, A Ziada, W Snodgrass
BACKGROUND: Teaching and learning hypospadias repair is a major component of pediatric urology fellowship training. Educators must transfer skills to fellows, without increasing patient complications. Nevertheless, few studies report results of surgeons during their first years of independent practice. PURPOSE: To review outcomes of distal hypospadias repairs performed during the same 2-year period by consecutive, recently matriculated, surgeons in independent practice, and to compare them to results by their mentor (with >20 years of experience)...
June 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27307964/complete-urethral-duplication-in-children-a-case-report
#16
Fatollah Roshanzamir, Alireza Mirshemirani, Javad Ghoroubi, Alireza Mahdavi, Leily Mohajerzadeh, Mehdi Sarafi
INTRODUCTION: Urethral duplication (UD) is a rare congenital anomaly with multiple anatomical variants. CASE PRESENTATION: In this article we present a four year-old child with complete UD. The patient was admitted for hypospadias repair, in evaluation we found type IIA1 UD according to Effmann classification. Patient underwent hypospadias repair saving complete UD. CONCLUSIONS: After one year follow-up he has normal and continent urination...
April 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27282422/quadrivalent-vaccine-targeted-human-papillomavirus-genotypes-in-heterosexual-men-after-the-australian-female-human-papillomavirus-vaccination-programme-a-retrospective-observational-study
#17
Eric P F Chow, Dorothy A Machalek, Sepehr N Tabrizi, Jennifer A Danielewski, Glenda Fehler, Catriona S Bradshaw, Suzanne M Garland, Marcus Y Chen, Christopher K Fairley
BACKGROUND: Australia introduced a national quadrivalent human papillomavirus (4vHPV) vaccination programme for girls and young women in April, 2007. The HPV genotypes targeted by the female vaccine could also affect the protection afforded to heterosexual men. We examined the prevalence of 4vHPV targeted vaccine genotypes and the nine-valent HPV (9vHPV)-targeted vaccines genotypes among sexually active, predominantly unvaccinated heterosexual men from 2004 to 2015. METHODS: We did a retrospective, observational study of urine and urethral swab specimens from heterosexual men aged 25 years or younger attending the Melbourne Sexual Health Centre between July 1, 2004, and June 30, 2015, who tested positive for Chlamydia trachomatis...
January 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27267991/urethral-duplication-in-girls-three-cases-associating-an-accessory-epispadiac-urethra-and-a-main-hypospadiac-urethra
#18
A Bouty, Y Lefevre, L Harper, E Dobremez
INTRODUCTION: Urethral duplication is extremely rare in girls, with less than 40 cases reported so far. Most of them present as a prepubic sinus. Literature is scare regarding aetiology, classification and management in other forms. This study presents three cases of sagittal urethral duplication in girls presenting a main hypospadiac urethra and an accessory epispadiac urethra. PATIENTS AND METHODS: Medical records were retrospectively reviewed of three girls with urethral duplication managed over a 30-year period at a single institution...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27261184/genetic-basis-of-posterior-urethral-valves-inheritance
#19
Cinzia Chiaramonte, Denisia Bommarito, Elisa Zambaiti, Vincenzo Antona, Giuseppe Li Voti
OBJECTIVE: To highlight genetic pattern of posterior urethral valves (PUVs), we performed a genetic study on 2 siblings affected. PUVs are the most common congenital cause of lower urinary tract obstruction and an important cause of renal failure in infants (50% progress to end-stage renal disease in 10 years). PUVs occur in 1 of 5000-8000 male infants, but real incidence is arduous to determine because of the wide spectrum of possible clinical presentation. A different recurrence rate is reported in African Americans and children with Down syndrome, although usually PUVs are not found in syndromic conditions but constitute an isolated disorder...
September 2016: Urology
https://www.readbyqxmd.com/read/27127361/urethral-duplication-with-unusual-cause-of-bladder-outlet-obstruction
#20
Vivek Venkatramani, Arun Jacob Philip George, J Chandrasingh, Arabind Panda, Antony Devasia
A 12-year-old boy presented with poor flow and recurrent urinary tract infections following hypospadias repair at the age of 3 years. The evaluation revealed urethral duplication with a hypoplastic dorsal urethra and patent ventral urethra. He also had duplication of the bladder neck, and on voiding cystourethrogram the ventral bladder neck appeared hypoplastic and compressed by the dorsal bladder neck during voiding. The possibility of functional obstruction of the ventral urethra by the occluded dorsal urethra was suspected, and he underwent a successful urethro-urethrostomy...
April 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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